Furuta H, Yamada M, Nagashima T, Matsuda S, Nagayasu K, Shirakawa H, Kaneko S. Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress. Front Pharmacol, 14:1137952 (2023) 

Zhou Z, Nagashima T, Toda C, Kobayashi M, Suzuki T, Nagayasu K, Shirakawa H, Asai S, Kaneko S. Vitamin D supplementation is effective for olanzapine-induced dyslipidemia. Front Pharmacol, 14:1135516 (2023)

Yamamoto H, Kayanuma G, Nagashima T, Toda C, Nagayasu K, Kaneko S. Early detection of adverse drug reaction signals by association rule mining using large-scale administrative claims data. Drug Saf (2023) 

https://doi.org/10.1007/s40264-023-01278-4

Nagai Y, Kisaka Y, Nomura K, Nishitani N, Andoh C, Koda M, Kawai H, Seiriki K, Nagayasu K, Kasai A, Shirakawa H, Nakazawa T, Hashimoto H, Kaneko S. Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience. Cell Rep, 42:112149 (2023)

Yamashita S, Dozono N, Tobori S, Nagayasu K, Kaneko S, Shirakawa H, Ueda H. Peripheral beta-2 adrenergic receptors mediate the sympathetic efferent activation from central nervous system to splenocytes in a mouse model of fibromyalgia. Int J Mol Sci, 24:3465 (2023)

Nagaoka K, Asaoka N, Nagayasu K, Shirakawa H, Kaneko S. Enhancement of adenosine A2A signaling improves dopamine D2 receptor antagonist-induced dyskinesia via beta-arrestin signaling. Front Neurosci, 16:1082375 (2023)

Nozawa K, Suzuki T, Kayanuma G, Yamamoto H, Nagayasu K, Shirakawa H, Kaneko S. Lisinopril prevents bullous pemphigoid induced by dipeptidyl peptidase 4 inhibitors via the Mas receptor pathway. Front Immunol, 13:1084960 (2023)

Zhou Z, Nagayasu K, Shirakawa H, Kaneko S. Specific cellular effects of low bortezomib concentrations on purified cultures of Schwann cells, satellite glial cells, macrophages, and dorsal root ganglion neurons. Biol Pharm Bull, 46:102-110 (2023)

Nagaoka K, Nagayasu K, Shirakawa H, Kaneko S: Acetaminophen improves tardive akathisia induced by dopamine D2
receptor antagonists. J Pharmacol Sci, 151:9-16 (2023)

Kawai H, Bouchekioua Y, Nishitani N, Niitani K, Izumi S, Morishita H, Andoh C, Nagai Y, Koda M, Hagiwara M, Toda K, Shirakawa H, Nagayasu K, Ohmura Y, Kondo M, Kaneda K, Yoshioka M, Kaneko S. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nat Commun, 13:7708 (2022)

Nagayasu K, Andoh C, Shirakawa H, Kaneko S. Diff-ATAC-STARR-Seq: A method for genome-wide functional screening of enhancer activity in vivo. Biol Pharm Bull, 45:1590-1595 (2022)

Kuronuma K, Susai N, Kuroita T, Yamamoto H, Yoshioka T, Kaneko S, Chiba H: Analysis of real-world data and a mouse model indicates that pirfenidone causes pellagra. ERJ Open Res, 8:00245-2022 (2022)

Takayama K, Tobori S, Andoh C, Kakae M, Hagiwara M, Nagayasu K, Shirakawa H, Ago Y, Kaneko S: Autism spectrum disorder model mice induced by prenatal exposure to valproic acid exhibit enhanced empathy-like behavior via oxytocinergic signaling. Biol Pharm Bull, 45:1124-1132 (2022)

Nakajima H, Fujita S, Kakae M, Nagayasu K, Oh-Hora M, Shirakawa H, Kaneko S: Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α-stimulated astrocytes. Glia, 70:1666-1680 (2022)

Hatakama H, Asaoka N, Nagayasu K, Shirakawa H, Kaneko S: A selective serotonin reuptake inhibitor ameliorates obsessive-compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex. Neuropharmacology. 206:108926 (2022)

Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue KI, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H: Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. Sci Adv, 8:eabi6375 (2022)

Watanabe H, Maekawa R, Iikuni S, Kakae M, Matsuo N, Shirakawa H, Kaneko S, Ono M: Characterization of radioiodinated diaryl oxadiazole derivatives as SPECT probes for detection of myelin in multiple sclerosis. ACS Chem Neurosci, 13:363-369 (2022)

Siswanto S, Yamamoto H, Furuta H, Kobayashi M, Nagashima T, Kayanuma G, Nagayasu K, Imai Y, Kaneko S: Drug repurposing prediction and validation from clinical big data for the effective treatment of interstitial lung disease. Front Pharmacol, 12:635293 (2021)

Tobori S, Hiyama H, Miyake T, Yano Y, Nagayasu K, Shirakawa H, Nakagawa T, Mori Y, Kaneko S: MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations. J Pharmacol Sci, 146:200-205 (2021) 

Tanaka K, Dozono N, Neyama H, Nagai J, Tsukahara R, Nagayasu K, Kaneko S, Ueda H: Secreted PLA2-III is a possible therapeutic target to treat neuropathic pain. Biochem Biophys Res Commun, 568:167-173 (2021)

Nagaoka K, Nagashima T, Asaoka N, Yamamoto H, Toda C, Kayanuma G, Siswanto S, Funahashi Y, Kuroda K, Kaibuchi K, Mori Y, Nagayasu K, Shirakawa H, Kaneko S: Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist-induced orofacial dyskinesia. JCI Insight, 6:145632 (2021)

Asaoka N, Ibi M, Hatakama H, Nagaoka K, Iwata K, Matsumoto M, Katsuyama M, Kaneko S, Yabe-Nishimura C: NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D2 Receptor Stimulation: Involvement in Behavioral Repetition. J Neurosci, 41:2780 (2021)

Sakai M, Nagayasu K, Shibui N, Andoh C, Takayama K, Shirakawa H, Kaneko S: Prediction of pharmacological activities from chemical structures with graph convolutional neural networks. Sci Rep, 11:525 (2021)

Uenoyama R, Miyazaki T, Hurst JL, Beynon RJ, Adachi M, Murooka T, Onoda I, Miyazawa Y, Katayama R, Yamashita T, Kaneko S, Nishikawa T, Miyazaki M: The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes. Sci Adv, 7:eabd9135 (2021)

Ohashi K, Shibasaki K, Nakazawa H, Kunimasa R, Nagayasu K, Shirakawa H, Kaneko S: Transient receptor potential melastatin 3 is functionally expressed in oligodendrocyte precursor cells and is upregulated in ischemic demyelinated lesions. Biol Pharm Bull, 44:181-187 (2021)

Kamei J, Aizawa N, Nakagawa T, Kaneko S, Fujimura T, Homma Y, Kume H, Igawa Y: Lacking transient receptor potential melastatin 2 attenuates lipopolysaccharide-induced bladder inflammation and its associated hypersensitivity in mice. Int J Urol, 28:107-114 (2021)

Ueda H, Dozono N, Tanaka K, Kaneko S, Neyama H, Uchida H: Allodynia by splenocytes from mice with acid-induced fibromyalgia-like generalized pain and its sexual dimorphic regulation by brain microglia. Front Neurosci, 14:600166 (2020)

Watanabe H, Sakai S, Iikuni S, Shimizu Y, Shirakawa S, Kaneko S, Ono M: Synthesis and biological evaluation of radioiodinated 3-phenylcoumarin derivatives targeting myelin in multiple sclerosis. Bioorg Med Chem Lett 30:127562-127562 (2020)

Inose Y, Izumi Y, Takada-Takatori Y, Akaike A, Koyama Y, Kaneko S, Kume T: Protective effects of Nrf2-ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: possible involvement of heme oxygenase-1. Neurosci Lett 736:135268-135268 (2020)

Asao Y, Tobori S, Kakae M, Nagayasu K, Shibasaki K, Shirakawa H, Kaneko S: Transient receptor potential vanilloid 4 agonist GSK1016790A improves neurological outcomes after intracerebral hemorrhage in mice. Biochem Biophys Res Commun 529:590-595 (2020)

Wada S, Yanagida J, Sasase H, Zhang T, Li X, Kamii H, Domoto M, Deyama S, Hinoi E, Yamanaka A, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K: Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice. Neuropharmacology 166:107968-107968 (2020)

Nagai Y, Takayama K, Nishitani N, Andoh C, Koda M, Shirakawa H, Nakagawa T, Nagayasu K, Yamanaka A,  Kaneko S: The role of dorsal raphe serotonin neurons in the balance between reward and aversion. Int J Mol Sci 21:2160 (2020)

Kaneko S, Nagashima T: [Review] Drug repositioning and target finding based on clinical evidence. Biol Pharm Bull 43:362-365 (2020)

Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K,  Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K: Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice. Addict Biol 25:e12723 (2020)

Nishitani N, Ohmura Y, Nagayasu K, Shibui N, Kaneko S, Ohashi A, Yoshida T, Yamanaka A, Yoshioka M: CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice. Brain Res, 1719:243-252 (2019)

Kakae M, Tobori S, Morishima M, Nagayasu K, Shirakawa H, Kaneko S: Depletion of microglia ameliorates white matter injury and cognitive impairment in a mouse chronic cerebral hypoperfusion model. Biochem Biophys Res Commun, 514:1040-1044 (2019)

Ito S, Deyama S, Domoto M, Zhang T, Sasase H, Fukao A, Esaki H, Hinoi E, Kaneko S, Kaneda K: Effects of the synthetic cannabinoid 5F-AMB on anxiety and recognition memory in mice. Psychopharmacology, 236:2235-2242 (2019)

Kakae M, Miyanohara J, Morishima M, Nagayasu K, Mori Y, Shirakawa H, Kaneko S: Pathophysiological role of TRPM2 in age-related cognitive impairment in mice. Neuroscience, 408:204-213 (2019)

Nishitani N, Nagayasu K, Asaoka N, Yamashiro M, Andoh C, Nagai Y, Kinoshita H, Kawai H, Shibui N, Liu B, Hewinson J, Shirakawa H, Nakagawa T, Hashimoto H, Kasparov S, Kaneko S: Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats. Neuropsychopharmacology, 44:721-732 (2019)

Asaoka N, Nishitani N, Kinoshita H, Nagai Y, Hatakama H, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: An adenosine A2A receptor antagonist improves multiple symptoms of repeated quinpirole induced psychosis. eNeuro, 6:0366-18 (2019)

Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, Shirakawa H, Kaneko S: TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Res, 1704:68-77 (2019)

Nagai Y, Nishitani N, Yasuda M, Ueda Y, Fukui Y, Andoh C, Shirakawa H, Nakagawa T, Inoue KI, Nagayasu K, Kasparov S, Nakamura K, Kaneko S: Identification of neuron-type specific promoters in monkey genome and their functional validation in mice. Biochem Biophys Res Commun, 518:619-624 (2019)

Kamei J, Aizawa N, Nakagawa T, Kaneko S, Kume H, Homma Y, Igawa Y: Attenuated lipopolysaccharide-induced inflammatory bladder hypersensitivity in mice deficient of transient receptor potential ankilin1. Sci Rep, 8:15622 (2018)

Nakanishi-Masuno T, Shitan N, Sugiyama A, Takanashi K, Inaba S, Kaneko S, Yazaki K: The Crotalaria juncea metal transporter CjNRAMP1 has a high Fe uptake activity, even in an environment with high Cd contamination. Int J Phytoremediation, 20:1427-1437 (2018)

Tsutsui M, Hirase R, Miyamura S, Nagayasu K, Nakagawa T, Mori Y, Shirakawa H, Kaneko S: TRPM2 exacerbates central nervous system inflammation in experimental autoimmune encephalomyelitis by increasing production of CXCL2 chemokines. J Neurosci, 38:8484-8495 (2018)

Isami K, Imai S, Sukeishi A, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain. Brain Behav Immun, 74:121-132 (2018) 

Shirakawa H, Kaneko S: Physiological and pathophysiological roles of transient receptor potential channels in microglia-related CNS inflammatory diseases [Review] Biol Pharm Bull, 41:1152-1157 (2018)

Hiyama H, Yano Y, So K, Imai S, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: TRPA1 sensitization during diabetic vascular impairment contributes to cold hypersensitivity in a mouse model of painful diabetic peripheral neuropathy. Mol Pain, 14:1-13 (2018)

Zhang T, Deyama S, Domoto M, Wada S, Yanagida J, Sasase H, Hinoi E, Nishitani N, Nagayasu K, Kaneko S, Kaneda K: Activation of GABAergic neurons in the nucleus accumbens mediates the expression of cocaine-associated memory. Biol Pharm Bull, 41:1084-1088 (2018)

Kawai H, Asaoka N, Miyake T, Nagayasu K, Nakagawa T, Shirakawa H, Kaneko S: Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons. J Pharmacol Sci, 137:313-316 (2018)

Domoto M, Sasase H, Wada S, Ito S, Deyama S, Hinoi E, Kaneko S, Kaneda K: The synthetic cannabinoid 5F-AMB changes the balance between excitation and inhibition of layer V pyramidal neurons in the mouse medial prefrontal cortex. Psychopharmacology, 235:2367-2376 (2018)

Miyanohara J, Kakae M, Nagayasu K, Nakagawa T, Mori Y, Arai K, Shirakawa H, Kaneko S: TRPM2 channel aggravates CNS inflammation and cognitive impairment via activation of microglia in chronic cerebral hypoperfusion. J Neurosci, 38:3520-3533 (2018)

Ohashi K, Deyashiki A, Miyake T, Nagayasu K, Shibasaki K, Shirakawa H, Kaneko S: TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation. Pflugers Arch, 470:705-716 (2018)

Kawaharada S, Nakanishi M, Nakanishi N, Hazama K, Higashino M, Lewis A, Clark GS, Chambers MS, Maidment SA, Yasuhiro T, Katsumata S, Kaneko S: ONO-8590580, a novel GABAA α5 negative allosteric modulator enhances long-term potentiation and improves cognitive deficits in preclinical model. J Pharmacol Exp Ther, 366:58-65 (2018)

Kinoshita H, Nishitani N, Nagai Y, Andoh C, Asaoka N, Kawai H, Shibui N, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: Ketamine-induced prefrontal serotonin release is mediated by cholinergic neurons in the pedunculopontine tegmental nucleus. Int J Neuropsychopharmacol, 21:305-310 (2018)

Sukeishi A, Isami K, Hiyama H, Imai S, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages. Mol Pain, 13:1 (2017)

Miyake T, Nakamura S, Meng Z, Hamano S, Inoue K, Numata T, Takahashi N, Nagayasu K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: Distinct mechanism of cysteine oxidation-dependent activation and cold sensitization of human transient receptor potential ankyrin 1 channel by high and low oxaliplatin. Front Physiol, 8:878 (2017)

Oyama S, Dogishi K, Kodera M, Kakae M, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: Pathophysiological role of transient receptor potential ankyrin 1 in a mouse long-lasting cystitis model induced by an intravesical injection of hydrogen peroxide. Front Physiol, 8:877 (2017)

Asaoka N, Nishitani N, Kinoshita H, Kawai H, Shibui N, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABAB receptor-mediated inhibition of L-type calcium channels. Sci Rep, 7:13609 (2017)

Kuramoto T, Yokoe M, Kunisawa N, Ohashi K, Miyake T, Higuchi Y, Yoshimi K, Mashimo T, Tanaka M, Kuwamura M, Kaneko S, Shimizu S, Serikawa T, Ohno Y: Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel. Brain Res, 1678:38 (2017)

Imai S, Koyamagi M, Azimi Z, Nakazato Y, Matsumoto M, Ogihara T, Yonezawa A, Omura T, Nakagawa S, Wakatsuki S, Araki T, Kaneko S: Nakagawa T, Matsubara K. Taxanes and platinum derivatives impair Schwann cells via distinct mechanisms. Sci Rep, 7: 5947 (2017)

Kaneko S: Motor vehicle collisions caused by the 'super-strength' synthetic cannabinoids, MAM-2201, 5F-PB-22, 5F-AB-PINACA, 5F-AMB and 5F-ADB in Japan experienced from 2012 to 2014. [Review] Forensic Toxicol, 35: 244-251 (2017)

Nakagawa T, Kaneko S: Roles of transient receptor potential ankyrin 1 in oxaliplatin-induced peripheral neuropathy. [Review] Biol Pharm Bull, 40:947 (2017)

Shirakawa H, Katsumoto R, Iida S, Miyake T, Higuchi T, Nagashima T, Nagayasu K, Nakagawa T, Kaneko S: Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes.Glia, 65: 1005-1016 (2017)

Dogishi K, Okamoto K, Majima T, Konishi-Shiotsu S, Homan T, Kodera M, Oyama S, Oyama T, Shirakawa H, Yoshimura N, Nakagawa T, Kaneko S: A rat long-lasting cystitis model induced by intravesical injection of hydrogen peroxide. Physiol Rep, 5: e13127 (2017)

Temma T, Yamazaki M, Miyanohara J, Shirakawa H, Kondo N, Koshino K, Kaneko S, Iida H: Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of 15O-gas in mice with bilateral common carotid artery stenosis. J Cereb Blood Flow Metab, 37:3334 (2017)

Asaoka N, Kawai H, Nishitani N, Kinoshita H, Shibui N, Nagayasu K, Shirakawa H, Kaneko S: A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons. J Toxicol Sci, 41: 813-816 (2016)

Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, Takahashi N, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat Commun, 7: 12840 (2016)

Nagashima T, Shirakawa H, Nakagawa T, Kaneko S: Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism.Sci Rep, 6: 26375 (2016)

So K, Tei Y, Zhao M, Miyake T, Hiyama H, Shirakawa H, Imai S, Mori Y, Nakagawa T, Matsubara K, Kaneko S: Hypoxia-induced sensitization of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice. Sci Rep, 6: 23261 (2016)

Dogishi K, Kodera M, Oyama S, Shirakawa H, Nakagawa T, Kaneko S: Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide. J Pharmacol Sci, 129: 244-246 (2015)

Miyake T, Shirakawa H, Nakagawa T, Kaneko S: Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration. Glia, 63: 1870-1882 (2015)

Nakatsuji H, Numata T, Morone N, Kaneko S, Mori Y, Imahori H, Murakami T: Thermosensitive ion channel activation in single neuronal cells by using surface-engineered plasmonic nanoparticles. Angew Chem Int Ed Engl, 54: 11725-11729 (2015)

Miyanohara J, Shirakawa H, Sanpei K, Nakagawa T, Kaneko S: A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice. Biochem Biophys Res Commun, 467: 478-483 (2015)

Imoto Y, Kira T, Sukeno M, Nishitani N, Nagayasu K, Nakagawa T, Kaneko S, Kobayashi K, Segi-Nishida E: Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrus. Mol Brain, 8: 29 (2015)

Asaoka N, Nagayasu K, Nishitani N, Yamashiro M, Shirakawa H, Nakagawa T, Kaneko S: Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT6 receptors in the dorsal raphe nucleus. Neuropharmacology, 95: 261-268 (2015)

Asaoka N, Nagayasu K, Nishitani N, Yamashiro M, Shirakawa H, Nakagawa T, Kaneko S: Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. Neurosci Lett, 593: 72-77 (2015)

Lee EY, Kaneko S, Jutabha P, Zhang X, Seino S, Jomori T, Anzai N, Miki T: Distinct action of the alpha-glucosidase inhibitor miglitol on SGLT3 and GLP1 secretion. J Endocrinol, 224: 205-214 (2015)

So K, Haraguchi K, Asakura K, Isami K, Sakimoto S, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models. J Pharmacol Sci, 127: 237-243 (2015)

Takahashi A, Nagayasu A, Nishitani N, Kaneko S, Koide T: Control of intermale aggression by medial prefrontal cortex activation in the mouse. PLoS One, 9: e94657 (2014)

Nishitani N, Nagayasu K, Asaoka N, Yamashiro M, Shirakawa H, Nakagawa T, Kaneko S: Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex. Int J Neuropsychopharmacol, 17: 1321-1326 (2014)

Zhao M, Nakamura S, Miyake T, So K, Shirakawa H, Tokuyama S, Narita M, Nakagawa T, Kaneko S: Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice. J Pharmacol Sci, 124: 514-517 (2014)

Miyake T, Shirakawa H, Kusano A, Sakimoto S, Konno M, Nakagawa T, Mori Y, Kaneko S: TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia. Biochem Biophys Res Commun, 444: 212-217 (2014)

Sakakiyama M, Maeda S, Isami K, Asakura K, So K, Shirakawa H, Nakagawa T, Kaneko S: Preventive and alleviative effect of tramadol on neuropathic pain in rats: roles of α2-adrenoceptors and spinal astrocytes. J Pharmacol Sci, 124: 244-257 (2014)

Nagayasu K, Kitaichi M, Nishitani N, Asaoka N, Shirakawa H, Nakagawa T, Kaneko S: Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release. Int J Neuropsychopharmacol, 16: 2295-2306 (2013)

Maki K, Kaneko S: Effective concentration-based serum pharmacodynamics for antifungal azoles in a murine model of disseminated Candida albicans infection. Eur J Drug Metab Pharmacokinet: 38: 261-268 (2013)

Isami K, Haraguchi K, So K, Maeda S, Asakura K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model. PLoS One, 8: e66410 (2013)

Munakata M, Shirakawa H, Nagayasu K, Miyanohara J, Miyake T, Nakagawa T, Katsuki H, Kaneko S: The TRPC3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice. Stroke, 44: 1981-1987 (2013)

Homan T, Tsuzuki T, Dogishi K, Shirakawa H, Oyama T, Nakagawa T, Kaneko S: A novel mouse model of chronic inflammatory and overactive bladder by a single intravesical injection of hydrogen peroxide. J Pharmacol Sci, 121: 327-337 (2013)

Nakagawa T, Nagayasu K, Nishitani N, Shirakawa H, Sekiguchi K, Ikarashi Y, Kase Y, Kaneko S. Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α2a-adrenoceptor. Neuroscience, 227: 336-349 (2012)

Zhao M, Isami K, Nakamura S, Shirakawa H, Nakagawa T, Kaneko S: Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol Pain, 8: 55 (2012)

Haraguchi K, Kawamoto A, Isami K, Maeda S, Kusano A, Asakura K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice. J Neurosci 32: 3931-3941 (2012)

Konno M, Shirakawa H, Iida S, Sakimoto S, Matsutani I, Miyake T, Kageyama K, Nakagawa T, Shibasaki K, Kaneko S: Stimulation of transient receptor potential vanilloid 4(TRPV4) channel suppresses abnormal activation of microglia induced by lipopolysaccharide. Glia 60: 761-770 (2012)

Konno M, Shirakawa H, Miyake T, Sakimoto S, Nakagawa T, Kaneko S: Calumin, a Ca2+-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca2+ release-activated Ca2+ (CRAC) channels. Biochem Biophys Res Commun 417: 784-789 (2012)

Ishida S, Sakamoto Y, Nishio T, Baulac S, Kuwamura M, Ohno Y, Takizawa A, Kaneko S, Serikawa T, Mashimo T: Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures. Brain Res 1435: 154-166 (2012)

Ibi M, Matsuno K, Matsumoto M, Sasaki M, Nakagawa T, Katsuyama M, Iwata K, Zhang J, Kaneko S, Yabe-Nishimura C: Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance. J Neurosci 31: 18094-18103 (2011)

Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, Mori Y: TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol 7: 701-711 (2011)

Nakagawa T, Suzuki Y, Nagayasu K, Kitaichi M, Shirakawa H, Kaneko S: Repeated exposure to methamphetamine, cocaine or morphine induces augmentation of dopamine release in rat mesocorticolimbic slice co-cultures. PLoS One 6: e24865 (2011)

Shirakawa H, Sakimoto S, Nakao K, Sugishita A, Konno M, Iida S, Kusano A, Hashimoto E, Nakagawa T, Kaneko S: TRPC3 Mediates thrombin-induced astrocyte activation and upregulates its own expression in rat cortical astrocytes. J Neurosci 30: 13116-13129 (2010)

Nagayasu K, Yatani Y, Kitaichi M, Kitagawa Y, Shirakawa H, Nakagawa T, Kaneko S. Utility of organotypic raphe slice cultures to investigate the effects of sustained exposure to selective serotonin reuptake inhibitors on serotonin release. Br J Pharmacol 161: 1527-1541 (2010)

Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, FujitaT, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem 285: 35123-35132 (2010)

Nagayasu K, Kitaichi M, Shirakawa H, Nakagawa T, Kaneko S: Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures. J Pharmacol Sci 113: 197-201 (2010)

Deyama S, Takishita A, Tanimoto S, Ide S, Nakagawa T, Satoh M, Minami M: Roles of beta- and alpha2-adrenoceptors within the central nucleus of the amygdala in the visceral pain-induced aversion in rats. J Pharmacol Sci 114: 123-126 (2010)

Deyama S, Katayama T, Kondoh N, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M: Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats. Behav Brain Res 197: 279-283 (2009)

Nishimura K, Unemura K, Tsushima J, Yamauchi Y, Otomo J, Taniguchi T, Kaneko S, Agata K, Kitamura Y: Identification of a novel planarian G-protein-coupled receptor that responds to serotonin in Xenopus laevis oocytes. Biol Pharm Bull 32: 1672-1677 (2009)

Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y: TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med 14: 738-747 (2008)

Maeda S, Kawamoto A, Yatani Y, Shirakawa H, Nakagawa T, Kaneko S: Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats. Mol Pain, 4: 65-78 (2008)

Shirakawa H, Yamaoka T, Sanpei K, Sasaoka H, Nakagawa T, Kaneko S: TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons. Biochem Biophys Res Commun, 377: 1211-1215 (2008)

Nakagawa T, Otsubo Y, Yatani Y, Shirakawa H, Kaneko S: Mechanisms of substrate transport-induced clustering of a glial glutamate transporter GLT-1 in astroglial-neuronal cultures. Eur J Neurosci, 28: 1719-1730 (2008)

Ibi M, Matsuno K, Shiba D, Katsuyama M, Iwara K, Kakehi T, Nakagawa T, Sango K, Shirai Y, Yokoyama T, Kaneko S, Saito N, Yabe-Nishimura, C: Ractive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain. J Neurosci, 28: 9486-9494 (2008)

Deyama S, Katayama T, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M: Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats. J Neurosci, 28: 7728-7736 (2008)

Higuchi M, Suzuki Y, Yatani Y, Kitagawa Y, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: Augmentation of serotonin release by sustained exposure to 3,4-methylenedioxymethamphetamine and methamphetamine in rat organotypic mesencephalic slice cultures containing raphe serotonergic neurons. J Neurochem, 106: 2410-2420 (2008)

Nakagawa T, Wakamatsu K, Maeda S, Shirakawa H, Kaneko S: Differential contribution of spinal mitogen-activated protein kinases to the phase of long-lasting allodynia evoked by intrathecal administration of ATP in rats. Biol Pharm Bull, 31: 1164-1168 (2008)

Kume T, Kawato Y, Osakada F, Izumi Y, Katsuki H, Nakagawa T, Kaneko S, Niidome T, Takada-Takatori Y, Akaike A: Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype. Neurosci Lett, 443: 199-203 (2008)

Nakao K, Shirakawa H, Sugishita A, Matsutani I, Niidome T, Nakagawa N, Kaneko S: Ca2+ mobilization mediated by transient receptor potential canonical 3 is associated with thrombin-induced morphological changes of 1321N1 human astrocytoma cells. J Neurosci Res, 86: 2722-2732 (2008)

Yamauchi Y, Izumi T, Unemura K, Uenishi Y, Nakagawa T, Kaneko S: Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethanphetamine (MDMA) under acidic conditions. Neurosci Lett, 428: 72-76 (2007)

Tanaka K, Shirakawa H, Okada K, Konno M, Nakagawa T, Serikawa T, Kaneko S: Increased Ca2+ channel currents in cerebellar Purkinje cells of the ataxic groggy rat. Neurosci Lett, 426: 75-80 (2007)

Deyama S, Yamamoto J, Machida T, Tanimoto S, Nakagawa T, Kaneko S, Satoh M, Minami M: Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces pain-induced aversion. Neurosci Res, 59: 199-204 (2007)

Nakagawa T, Wakamatsu K, Zhang N, Maeda S, Minami M, Satoh M, Kaneko S: Intrathecal administration of ATP produces long-lasting allodynia in rats: differential mechanisms in the phase of the induction and maintenance. Neuroscience, 147: 445-455 (2007)

Deyama S, Nakagawa T, Kaneko S, Uehara T, Minami M: Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats. Behav Brain Res, 176: 367-371 (2007)

Shimamoto K, Otsubo Y, Shigeri Y, Yasuda-Kamatani Y, Satoh M, Kaneko S, Nakagawa T: Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol, 71: 294-302 (2007)

Tokuda S, Kuramoto T, Tanaka K, Kaneko S, Takeuchi IK, Sasa M, Serikawa T: The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures. Brain Res, 1133: 168-177 (2007)

Kume T, Taguchi R, Katsuki H, Akao M, Sugimoto H, Kaneko S, Akaike A. Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation. Eur J Pharmacol, 542: 69-76 (2006)

Fukui M, Nakagawa T, Minami M, Satoh M, Kaneko S. Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats. Mol Pain, 2: 19 (2006)

Kaneko S, Kawakami S, Hara Y, Wakamori M, Itoh E, Minami T, Takada Y, Kume K, Katsuki H, Mori Y, Akaike A. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci, 101: 66-76 (2006)

Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A: Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons. Br J Pharmacol, 147: 729-736 (2006)

Yazaki K, Yamanaka N, Masuno T, Konagai S, Shitan N, Kaneko S, Ueda K, Sato F: Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation. Plant Mol Biol, 61: 491-503 (2006)

Kinoshita-Kawada M, Tang J, Xial R, Kaneko S, Foskett JK, Zhu MX: Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch Eur J Physiol 450: 345-354 (2005)

Fujio M, Nakagawa T, Suzuki Y, Satoh M, Kaneko S: Facilitative effect of a glutamate transporter inhibitor (2S,3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate on the expression of methamphetamine-induced behavioral sensitization in rats. J Pharmacol Sci, 99: 415-418 (2005)

Fujio M, Nakagawa T, Sekiya Y, Ozawa T, Suzuki Y, Minami M, Satoh M, Kaneko S: Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats. Eur J Neurosci, 22: 2744-2754 (2005)

Nakagawa T, Yamamoto R, Fujio M, Suzuki S, Minami M, Satoh M, Kaneko S: Involvement of the bed nucleus of the stria terminalis activated by the central nucleus of the amygdala in the negative affective component of morphine withdrawal in rats. Neuroscience, 134: 9-19 (2005)

Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A: Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons. Eur J Neurosci, 21: 2329-2335 (2005)

Toyohara H, Yamamoto S, Hosoi M, Takagi M, Hayashi I, Nakao K, Kaneko S: Scallop DMT functions as a Ca2+ transporter. FEBS Lett, 579: 2727-2730 (2005)

Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A: alpha-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology, 47: 904-915 (2004)

Fujimoto S, Katsuki H, Kume T, Kaneko S, Akaike A: Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures. Neurosci Res, 50: 179-187 (2004)