生命薬科学専攻
分子微生物学分野
京都大学大学院薬学研究科
生命薬科学専攻
分子微生物学分野
No English version
業績 Publications[2010 - 2001] [2000 - 1991] [1990 - 1981] [1980-1973]
Yamamoto Y, Yoshimasa Y, Koh M, Suga J, Masuzaki H, Ogawa Y, Hosoda K, Nishimura H, Watanabe Y, Inoue G, Nakao K. "Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes." Diabetes. 2000;49(3):332-339. [Pubmed]
Kimura, G., Takimoto, H., Yoshida, H., Hamano, S., Li, W., Watanabe, Y., Ohtsu, M. and Nomoto, K.: Roles of alveolar macrophages in defense against experimental pulmonary infection of mice with murine cytomegalovirus. Biomedical Res. 21: 145-163 (2000)
Ichinose Y, Okino T, Yamasaki S, Moriguchi Y, Sugie T, Li L, Kanaoka S, Kan N, Watanabe Y, Imamura M. "Reduction of tumorigenicity by an interferon-gamma-gene-transduced tumor on another syngeneic tumor in a murine model." Surg Today. 1999;29(4):338-343. [Pubmed]
Okamoto S, Nakanishi K, Watanabe Y, Yamashita F, Takakura Y, Hashida M. "Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-beta from polarized epithelial cell lines." Biochem Biophys Res Commun. 1999;254(1):5-9. [Pubmed]
Nomura T, Yasuda K, Yamada T, Okamoto S, Mahato RI, Watanabe Y, Takakura Y, Hashida M. "Gene expression and antitumor effects following direct interferon (IFN)-gamma gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice." Gene Ther. 1999;6(1):121-129. [Pubmed]
Okamoto S, Watanabe Y, Takakura Y, Hashida M. "Cationic liposome-mediated efficient induction of type I interferons by a low dose of poly I:poly C in mouse cell lines." J Biochem (Tokyo). 1998;124(4):697-701. [Pubmed]
Moriguchi Y, Kan N, Okino T, Teramura Y, Yamasaki S, Ichinose Y, Li L, Sugie T, Kuribayashi K, Watanabe Y, Imamura M. "The effectiveness of active specific immunotherapy using interferon-gamma-gene-transduced tumor cells in a murine tumor model." Surg Today. 1997;27(6):571-573. [Pubmed]
Kiyokawa T, Umemoto T, Watanabe Y, Matsushita S, Shida H. "Two distinct pathways for intronless mRNA expression: one related, the other unrelated to human immunodeficiency virus Rev and human T cell leukemia virus type I Rex functions." Biol Signals. 1997;6(3):134-142. [Pubmed]
Kawabata K, Kondo M, Watanabe Y, Takakura Y, Hashida M. "Non-polarized secretion of mouse interferon-beta from gene-transferred human intestinal Caco-2 cells." Pharm Res. 1997;14(4):483-485. [Pubmed]
Yokoyama S, Ohishi N, Shamoto M, Watanabe Y, Yagi K. "Isolation and expression of rat interferon beta gene and growth-inhibitory effect of its expression on rat glioma cells." Biochem Biophys Res Commun. 1997;232(3):698-701. [Pubmed]
Kawabata K, Okamoto S, Takakura Y, Hashida M, Hashimura T, Watanabe Y. "A physiological role of interferon (IFN)-beta derived from tumor: tumor growth of a mouse bladder carcinoma line MBT-2 is partially suppressed by autocrine IFN-beta." Cancer Lett. 1997;113(1-2):159-164. [Pubmed]
Y. Watanabe: Tumor cell-targeted cytokine gene therapy of cancer. In "Proceedings of 23rd International Symposium of Controlled Release of Bioactive Materials," pp. 172-173 (1996)
Kobayashi F, Morii T, Matsui T, Fujino T, Watanabe Y, Weidanz WP, Tsuji M. "Production of interleukin 10 during malaria caused by lethal and nonlethal variants of Plasmodium yoelii yoelii." Parasitol Res. 1996;82(5):385-391. [Pubmed]
M. Harutsumi, T. Aji, A. Manki, M. Hikida, H. Omori, Y. Watanabe, Y. Teramura, K. Kuribayashi, Y. Seino, E. Nakayama: Rejection of parental Meth A tumor on concomitant inoculation of Meth A cells infected retrovirally with the interferon-γ gene into (BALB/c x C57BL/6)F1 mice. Int. J. Oncol. 7: 233-238 (1995)
K. Tahara, Y. Watanabe, M. Kohiyama: Rapid and sensitive detection of Mycoplasma contamination in cell cultures based on Mycoplasmic endonuclease activity. J. Tokyo Medical College 53: 139-144 (1995)
Nakajima H, Nakao A, Watanabe Y, Yoshida S, Iwamoto I. "IFN-alpha inhibits antigen-induced eosinophil and CD4+ T cell recruitment into tissue." J Immunol. 1994;153(3):1264-1270. [Pubmed]
Nishio A, Hosono M, Watanabe Y, Sakai M, Okuma M, Masuda T. "A conserved epitope on H+,K(+)-adenosine triphosphatase of parietal cells discerned by a murine gastritogenic T-cell clone." Gastroenterology. 1994;107(5):1408-1414. [Pubmed]
Mabuchi A, Watari E, Ikeda M, Watanabe Y, Yokomuro K. "Growth control of primary culture hepatocytes by nonparenchymal liver cells. Role of interferon produced by liver sinusoidal cells." Nippon Ika Daigaku Zasshi. 1994;61(2):120-128. [Pubmed]
Y. Watanabe: Tumorigenicity and immunogenicity of IFN-γ-producing tumor cells. In Proc. 9th Nagoya Int. Symp. on Cancer Treat. (Excepta Medica International Congress Series), pp.90 - 95, Excepta Medica, Tokyo (1994)
Hiura M, Hashimura T, Watanabe Y, Kuribayashi K, Yoshida O. "Induction of specific anti-tumour immunity by interferon-gamma gene-transferred murine bladder carcinoma MBT-2." Folia Biol (Praha). 1994;40(1-2):49-61. [Pubmed]
Fujihara M, Ito N, Pace JL, Watanabe Y, Russell SW, Suzuki T. "Role of endogenous interferon-beta in lipopolysaccharide-triggered activation of the inducible nitric-oxide synthase gene in a mouse macrophage cell line, J774." J Biol Chem. 1994;269(17):12773-12778. [Pubmed]
Yanagihara K, Seyama T, Watanabe Y. "Antitumor potential of interferon-gamma: retroviral expression of mouse interferon-gamma cDNA in two kinds of highly metastatic mouse tumor lines reduces their tumorigenicity." Nat Immun. 1994;13(2-3):102-112. [Pubmed]
Murakami K, Hosono M, Maruyama H, Mori Y, Nishio A, Fukumoto M, Watanabe Y, Inaba M, Kuribayashi K, Sakai M. "Concomitant enhancement of the response to Mls-1a antigens and the induction of post-thymectomy autoimmune gastritis in BALB/c mice." Clin Exp Immunol. 1993;92(3):500-505. [Pubmed]
Teramura Y, Watanabe Y, Kan N, Masuda T, Kuribayashi K. "Interferon-gamma-producing tumor induces host tumor-specific T cell responses." Jpn J Cancer Res. 1993;84(6):689-696. [Pubmed]
Porgador A, Bannerji R, Watanabe Y, Feldman M, Gilboa E, Eisenbach L. "Antimetastatic vaccination of tumor-bearing mice with two types of IFN-gamma gene-inserted tumor cells." J Immunol. 1993;150(4):1458-1470. [Pubmed]
Burrows FJ, Watanabe Y, Thorpe PE. "A murine model for antibody-directed targeting of vascular endothelial cells in solid tumors." Cancer Res. 1992;52(21):5954-5962. [Pubmed]
Meurs EF, Watanabe Y, Kadereit S, Barber GN, Katze MG, Chong K, Williams BR, Hovanessian AG. "Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth." J Virol. 1992;66(10):5805-5814. [Pubmed]
Gyotoku J, el-Farrash MA, Fujimoto S, Germeraad WT, Watanabe Y, Teshigawara K, Harada S, Katsura Y. "Inhibition of human immunodeficiency virus replication in a human T cell line by antisense RNA expressed in the cell." Virus Genes. 1991;5(3):189-202. [Pubmed]
Maruguchi Y, Toda K, Watanabe Y, Imamura S. "Modulatory effects of interferon-gamma on the fibronectin receptor function of squamous cell carcinoma cells in vitro." J Dermatol Sci. 1991;2(6):422-427. [Pubmed]
Maruguchi Y, Toda KI, Fujii K, Imamura S, Watanabe Y. "Survival period of tumor-bearing mice is prolonged after the interferon-gamma-producing gene transfer." Cancer Lett. 1991;60(1):41-49. [Pubmed]
Kitaura M, Inaba K, Inaba M, Ogata H, Watanabe Y, Shimizu S, Ikehara S, Muramatsu S. "Interferon-alpha and interferon-beta induce Ia expression in limited protein synthesis condition." J Interferon Res. 1990;10(5):487-496. [Pubmed]
Miyatake S, Nishihara K, Kikuchi H, Yamashita J, Namba Y, Hanaoka M, Watanabe Y. "Efficient tumor suppression by glioma-specific murine cytotoxic T lymphocytes transfected with interferon-gamma gene." J Natl Cancer Inst. 1990;82(3):217-220. [Pubmed]
Watanabe Y, Kuribayashi K, Miyatake S, Nishihara K, Nakayama E, Taniyama T, Sakata T. "Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity." Proc Natl Acad Sci U S A. 1989;86(23):9456-9460. [Pubmed]
Kato T, Kitaura M, Inaba K, Watanabe Y, Kawade Y, Muramatsu S. "Suppression of macrophage Ia antigen expression by endogenous interferon-alpha/beta." J Interferon Res. 1989;9(4):393-405. [Pubmed]
Hitoshi Y, Mita S, Tominaga A, Kikuchi Y, Sonoda E, Takatsu K, Watanabe Y. "Interferon-gamma inhibits the proliferation but not the differentiation of murine B cells in response to IL-5." Int Immunol. 1989;1(2):185-90. [Pubmed]
Hitoshi Y, Mita S, Tominaga A, Kikuchi Y, Sonoda E, Takatsu K, Watanabe Y. "Interferon-gamma inhibits the proliferation but not the differentiation of murine B cells in response to IL-5." Int Immunol. 1989;1(2):185-90. [Pubmed]
Y. Watanabe, K. Nishihara, S. Miyatake, J. Yamashita, T. Sakata & Y. Namba: A new therapeutic potential of IFN-γ: augmentation of tumor targeting of glioma-specific murine cytotoxic T lymphocytes by retroviral expression of IFN-γ gene. In "The Biology of the Interferon System 1988" (eds. Y. Kawade & S. Kobayashi), pp. 239-243, Kodansha Scientific, Tokyo (1989)
Nishihara K, Miyatake S, Sakata T, Yamashita J, Kikuchi H, Kawade Y, Zu Y, Namba Y, Hanaoka M, Watanabe Y. "Augmentation of tumor targeting in a line of glioma-specific mouse cytotoxic T-lymphocytes by retroviral expression of mouse gamma-interferon complementary DNA." Cancer Res. 1988;48(17):4730-4735. [Pubmed]
Watanabe Y, Sakata T. "Highly efficient action of autocrine mouse interferon-gamma expressed via a retroviral vector." Eur J Immunol. 1988;18(10):1627-1630. [Pubmed]
Kitaura M, Kato T, Inaba K, Watanabe Y, Kawade Y, Muramatsu S. "Ontogeny of 'macrophage' function. VI. Down-regulation for Ia-expression of newborn mouse macrophages by endogenous beta-interferon." Dev Comp Immunol. 1988;12(3):645-655. [Pubmed]
Iwata A, Watanabe Y, Sakata T, Sokawa Y, Kawade Y. "Characterization of L1210 S cells with low sensitivity to mouse interferon-gamma." Microbiol Immunol. 1988;32(6):597-605. [Pubmed]
Watanabe Y, Kawade Y. "Suppressive effects of mouse interferon-beta on gene expression occurring in concanavalin A-stimulated mouse spleen cells." Immunology. 1988;64(4):739-741. [Pubmed]
Kitaura M, Kato T, Inaba K, Sakata T, Watanabe Y, Kawade Y, Muramatsu S. "Down-regulation of macrophage Ia mRNA expression by interferon (IFN)-alpha and IFN-beta mediated by de novo synthesized protein." Cell Immunol. 1988;114(2):347-358. [Pubmed]
Ohno T, Fujii H, Kanoh T, Uchino H, Kuribayashi K, Masuda T, Watanabe Y. "Selective deficiency in IL-2 production and refractoriness to extrinsic IL-2 in immunodeficiency with hyper-IgM." Clin Immunol Immunopathol. 1987;45(3):471-480. [Pubmed]
Y. Kawade & Y. Watanabe: Characterization of rat monoclonal antibodies to mouse interferon-α and -β. In "The Biology of the Interferon System 1986" (eds. K Cantell & H.Schellekens), pp. 197-201, Martinus Nijhoff, Dordrecht (1987)
Ito M, Ishida E, Tanabe F, Shigeta S, Watanabe Y, Kawade Y. "Interferon-alpha enhances the production of leukotriene B4 in murine peritoneal macrophages stimulated by opsonized zymosan." Immunology. 1987;60(4):617-619. [Pubmed]
Belardelli F, Gessani S, Proietti E, Locardi C, Borghi P, Watanabe Y, Kawade Y, Gresser I. "Studies on the expression of spontaneous and induced interferons in mouse peritoneal macrophages by means of monoclonal antibodies to mouse interferons." J Gen Virol. 1987;68 ( Pt 8):2203-2212. [Pubmed]
Y. Kawade & Y. Watanabe: On the nature of neutralization reaction between interferon and antibody. In "The Biology of the Interferon System 1985"(eds. W.E. Stewart & H. Schellekens), pp. 87-93, Elsevier, Amsterdam (1986)
Inaba K, Kitaura M, Kato T, Watanabe Y, Kawade Y, Muramatsu S. "Contrasting effect of alpha/beta- and gamma-interferons on expression of macrophage Ia antigens." J Exp Med. 1986;163(4):1030-1035. [Pubmed]
Kawade Y, Watanabe Y. "The nature of neutralization reaction between effector protein and monoclonal antibody: a quantitative study of neutralization characteristics of anti-interferon antibodies." Immunology. 1985;56(3):489-495. [Pubmed]
Watanabe Y. "Molecular properties of mouse interferon-gamma." Nippon Ketsueki Gakkai Zasshi. 1984;47(8):1632-1634. [Pubmed]
Kasakura S, Taguchi M, Watanabe Y, Okubo T, Murachi T, Uchino H, Hanaoka M. "A mitogenic factor, released by stimulated human mononuclear cells and distinct from interleukin 2 (IL 2), B cell growth factor (BCGF), and interleukin 1 (IL 1)." J Immunol. 1984;133(6):3084-3090. [Pubmed]
Yamasaki T, Handa H, Yamashita J, Watanabe Y, Namba Y, Hanaoka M. "Specific adoptive immunotherapy with tumor-specific cytotoxic T-lymphocyte clone for murine malignant gliomas." Cancer Res. 1984;44(5):1776-1783. [Pubmed]
Yamasaki T, Handa H, Yamashita J, Namba Y, Watanabe Y, Kuwata S, Hanaoka M. "Establishment of experimental malignant glioma-specific cytotoxic T lymphocyte clone by T cell growth factor." J Neurosurg. 1984;60(5):998-1004. [Pubmed]
Machida H, Kawade Y, Watanabe Y. "Antigenicity of mouse interferons induced in vitro and in vivo by poly(I).poly(C)." J Interferon Res. 1984;4(3):347-353. [Pubmed]
Kawade Y, Watanabe Y. "Neutralization of interferon by antibody: appraisals of methods of determining and expressing the neutralization titer." J Interferon Res. 1984;4(4):571-584. [Pubmed]
Y. Kawade & Y. Watanabe: Molecular aspects of interferon: an overview of current studies on mouse interferon. In "Beitrage zur Onkologie, Vol. 20, Physiology and Pathology of Interferon System" (ed. L. Borecky), pp. 15-24, Karger (1984)
Y. Watanabe, M. Taguchi, A. Iwata, Y. Namba, Y. Kawade & M. Hanaoka: Characterization of mouse interferon-γ from a clonal T cell line. In "The Biology of the Interferon System 1983" (eds. E. DeMaeyer and H. Schellekens), pp. 143-148, Elsevier (1983)
Watanabe Y, Kawade Y. "Properties of non-glycosylated human interferon-beta from MG63 cells." J Gen Virol. 1983;64 (Pt 6):1391-1395. [Pubmed]
Watanabe Y. "Production and purification of human MG63 cell interferon." Microbiol Immunol. 1983;27(5):433-444. [Pubmed]
Kasakura S, Taguchi M, Watanabe Y, Okubo T, Murachi T, Uchino H, Hanaoka M. "Suppressor cell induction factor: a new mediator released by stimulated human lymphocytes and distinct from previously described lymphokines." J Immunol. 1983;130(6):2720-2726. [Pubmed]
Higashi Y, Sokawa Y, Watanabe Y, Kawade Y, Ohno S, Takaoka C, Taniguchi T. "Structure and expression of a cloned cDNA for mouse interferon-beta." J Biol Chem. 1983;258(15):9522-9529. [Pubmed]
Matsuyama M, Hinuma Y, Watanabe Y, Kawade Y. "Production of interferon-beta by human lymphoblastoid cells of T and non-T--non-B lineages." J Gen Virol. 1982;60(Pt 1):191-194. [Pubmed]
Kawade Y, Watanabe Y, Yamamoto Y, Fujisawa J, Dalton BJ, Paucker K. "Antigenic cross-reaction between the alpha types of human and mouse interferon." Antiviral Res. 1981;1(3):167-178. [Pubmed]
Kawade Y, Yamamoto Y, Fujisawa J, Watanabe Y. "Antigenic relationships among various interferon species." Ann N Y Acad Sci. 1980;350:422-427. [Pubmed]
Sokawa Y, Watanabe Y, Watanabe Y, Kawade Y. "Interferon suppresses the transition of quiescent 3T3 cells to a growing state." Nature. 1977;268(5617):236-238. [Pubmed]
Ogasawara N, Watanabe Y, Inoue Y. "Determination of microscopic basic ionization constants of guanylyl-(3'-5')-guanosine. Structure and optical properties of half-protonated guanylyl-(3'-5')guanosine and their models." J Am Chem Soc. 1975;97(22):6571-6576. [Pubmed]
Y. Watanabe & Y. Inoue: Oligonucleotide studies 10. Structure and optical properties of N1- and N2-methylguanylyl-3',5'-uridine. FEBS Letters 35: 344-348 (1973) [ScienceDirect]
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