京都大学大学院薬学研究科　生体機能解析学分野
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Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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代表的論文

炎症性/神経障害性疼痛のマクロファージおよびミクログリア活性化におけるTRPM2の役割

脳内出血後のアストログリアの異常活性化におけるTRPC3の役割

縫線核切片培養系を用いた抗うつ薬SSRIおよび合成麻薬MDMAによる持続的5-HT遊離

大脳皮質神経細胞死におけるTRPV1の関与

抗がん剤オキサリプラチンによる急性末梢神経障害におけるTRPA1の役割

神経因性疼痛におけるアストログリアのグルタミン酸輸送体GLT-1 (EAAT2)の役割

過酸化水素が誘発する神経細胞死におけるTRPM2の関与

原著論文（2004年以降、PubMedにリンクしています）
  1. Nagayasu K, Kitaichi M, Nishitani N, Asaoka N, Shirakawa H, Nakagawa T, Kaneko S: Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release. Int J Neuropsychopharmacol, in press
  2. Isami K, Haraguchi K, So K, Maeda S, Asakura K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model. PLOS ONE, in press
  3. Munakata M, Shirakawa H, Nagayasu K, Miyanohara J, Miyake T, Nakagawa T, Katsuki H, Kaneko S: The TRPC3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice. Stroke, in press
  4. Homan T, Tsuzuki T, Dogishi K, Shirakawa H, Oyama T, Nakagawa T, Kaneko S: A novel mouse model of chronic inflammatory and overactive bladder by a single intravesical injection of hydrogen peroxide. J. Pharmacol. Sci., 121, 327-337 (2013)
  5. Nakagawa T, Nagayasu K, Nishitani N, Shirakawa H, Sekiguchi K, Ikarashi Y, Kase Y, Kaneko S. Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α2a-adrenoceptor. Neuroscience, 227, 336-349 (2012)
  6. Zhao M, Isami K, Nakamura S, Shirakawa H, Nakagawa T, Kaneko S: Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol. Pain, 8, 55 (2012)
  7. Haraguchi K, Kawamoto A, Isami K, Maeda S, Kusano A, Asakura K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S.TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice. J. Neurosci. 32, 3931-3941 (2012)
  8. Konno M, Shirakawa H, Iida S, Sakimoto S, Matsutani I, Miyake T, Kageyama K, Nakagawa T, Shibasaki K, Kaneko S. Stimulation of transient receptor potential vanilloid 4(TRPV4) channel suppresses abnormal activation of microglia induced by lipopolysaccharide. Glia 60, 761-770 (2012)
  9. Konno M, Shirakawa H, Miyake T, Sakimoto S, Nakagawa T, Kaneko S. Calumin, a Ca2+-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca2+ release-activated Ca2+ (CRAC) channels. Biochem. Biophys. Res. Commun. 417, 784-789 (2012)
  10. Ishida S, Sakamoto Y, Nishio T, Baulac S, Kuwamura M, Ohno Y, Takizawa A, Kaneko S, Serikawa T, Mashimo T. Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures. Brain Res. 1435, 154-166 (2012)
  11. Ibi M, Matsuno K, Matsumoto M, Sasaki M, Nakagawa T, Katsuyama M, Iwata K, Zhang J, Kaneko S, Yabe-Nishimura C. Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance. J. Neurosci. 31, 18094-18103 (2011)
  12. Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, Mori Y. TRPA1 underlies a sensing mechanism for O2. Nat. Chem. Biol. 7, 701-711 (2011)
  13. Nakagawa T, Suzuki Y, Nagayasu K, Kitaichi M, Shirakawa H, Kaneko S. Repeated exposure to methamphetamine, cocaine or morphine induces augmentation of dopamine release in rat mesocorticolimbic slice co-cultures. PLoS One 6, e24865 (2011)
  14. Shirakawa H., Sakimoto S., Nakao K., Sugishita A., Konno M., Iida S., Kusano A., Hashimoto E., Nakagawa T., Kaneko S. TRPC3 Mediates thrombin-induced astrocyte activation and upregulates its own expression in rat cortical astrocytes. J. Neurosci. 30, 13116-13129 (2010)
  15. Nagayasu K., Yatani Y., Kitaichi M., Kitagawa Y., Shirakawa H., Nakagawa T., Kaneko S. Utility of organotypic raphe slice cultures to investigate the effects of sustained exposure to selective serotonin reuptake inhibitors on serotonin release. Br. J. Pharmacol. 161, 1527-1541 (2010)
  16. Jutabha P., Anzai N., Kitamura K., Taniguchi A., Kaneko S., Yan K., Yamada H., Shimada H., Kimura T., Katada T., Fukutomi T., Tomita K., Urano W., Yamanaka H., Seki G., FujitaT., Moriyama Y., Yamada A., Uchida S., Wempe M.F. Endou H., Sakurai H. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J. Biol. Chem. 285, 35123-35132 (2010)
  17. Nagayasu K., Kitaichi M., Shirakawa H., Nakagawa T., Kaneko S. Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures. J. Pharmacol. Sci. 113, 197-201 (2010)
  18. Deyama S., Takishita A., Tanimoto S., Ide S., Nakagawa T., Satoh M., Minami M. Roles of beta- and alpha2-adrenoceptors within the central nucleus of the amygdala in the visceral pain-induced aversion in rats. J. Pharmacol. Sci. 114, 123-126 (2010)
  19. Deyama S., Katayama T., Kondoh N., Nakagawa T., Kaneko S., Yamaguchi T., Yoshioka M., Minami M. Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats. Behav. Brain Res. 197, 279-283 (2009)
  20. Nishimura K., Unemura K., Tsushima J., Yamauchi Y., Otomo J., Taniguchi T., Kaneko S., Agata K., Kitamura Y. Identification of a novel planarian G-protein-coupled receptor that responds to serotonin in Xenopus laevis oocytes. Biol. Pharm. Bull. 32, 1672-1677 (2009)
  21. Yamamoto S., Shimizu S., Kiyonaka S., Takahashi N., Wajima T., Hara Y., Negoro T, Hiroi T., Kiuchi Y., Okada T., Kaneko S., Lange I., Fleig A., Penner R., Nishi M., Takeshima H., Mori Y. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat. Med. 14, 738-747 (2008)
  22. Maeda S., Kawamoto A., Yatani Y., Shirakawa H., Nakagawa T., Kaneko S. Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats. Mol. Pain, 4, 65-78 (2008)
  23. Shirakawa H., Yamaoka T., Sanpei K., Sasaoka H., Nakagawa T., Kaneko S. TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons. Biochem. Biophys. Res. Commun., 377, 1211-1215 (2008)
  24. Nakagawa T., Otsubo Y., Yatani Y., Shirakawa H., Kaneko S. Mechanisms of substrate transport-induced clustering of a glial glutamate transporter GLT-1 in astroglial-neuronal cultures. Eur. J. Neurosci., 28, 1719-1730 (2008)
  25. Ibi M., Matsuno K., Shiba D., Katsuyama M., Iwara K., Kakehi T., Nakagawa T., Sango K., Shirai Y., Yokoyama T., Kaneko S., Saito N., Yabe-Nishimura, C. Ractive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain. J. Neurosci., 28, 9486-9494 (2008)
  26. Deyama S., Katayama T., Nakagawa T., Kaneko S., Yamaguchi T., Yoshioka M., Minami M. Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats. J. Neurosci., 28, 7728-7736 (2008)
  27. Higuchi M., Suzuki Y., Yatani Y., Kitagawa Y., Nagayasu K., Shirakawa H., Nakagawa T., Kaneko S. Augmentation of serotonin release by sustained exposure to 3,4-methylenedioxymethamphetamine and methamphetamine in rat organotypic mesencephalic slice cultures containing raphe serotonergic neurons. J. Neurochem., 106, 2410-2420 (2008)
  28. Nakagawa T., Wakamatsu K., Maeda S., Shirakawa H., Kaneko S., Differential contribution of spinal mitogen-activated protein kinases to the phase of long-lasting allodynia evoked by intrathecal administration of ATP in rats. Biol. Pharm. Bull., 31, 1164-1168 (2008)
  29. Kume T., Kawato Y., Osakada F., Izumi Y., Katsuki H., Nakagawa T., Kaneko S., Niidome T., Takada-Takatori Y., Akaike A. Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype. Neurosci. Lett., 443, 199-203 (2008)
  30. Nakao K, Shirakawa H., Sugishita A., Matsutani I., Niidome T., Nakagawa N., Kaneko S. Ca2+ mobilization mediated by transient receptor potential canonical 3 is associated with thrombin-induced morphological changes of 1321N1 human astrocytoma cells. J. Neurosci. Res., 86, 2722-2732 (2008)
  31. Yamauchi Y., Izumi T., Unemura K., Uenishi Y., Nakagawa T., Kaneko S. Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethanphetamine (MDMA) under acidic conditions. Neurosci. Lett., 428, 72-76 (2007)
  32. Tanaka K., Shirakawa H., Okada K., Konno M., Nakagawa T., Serikawa T., Kaneko S. Increased Ca2+ channel currents in cerebellar Purkinje cells of the ataxic groggy rat. Neurosci. Lett., 426, 75-80 (2007)
  33. Deyama S., Yamamoto J., Machida T., Tanimoto S., Nakagawa T., Kaneko S., Satoh M., Minami M. Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces pain-induced aversion. Neurosci. Res., 59, 199-204 (2007)
  34. Nakagawa T., Wakamatsu K., Zhang N., Maeda S., Minami M., Satoh M., Kaneko S. Intrathecal administration of ATP produces long-lasting allodynia in rats: differential mechanisms in the phase of the induction and maintenance. Neuroscience, 147, 445-455 (2007)
  35. Deyama S., Nakagawa T., Kaneko S., Uehara T., Minami M. Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats. Behav. Brain Res., 176, 367-371 (2007)
  36. Shimamoto K., Otsubo Y., Shigeri Y., Yasuda-Kamatani Y., Satoh M., Kaneko S., Nakagawa T. Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol. Pharmacol., 71, 294-302 (2007)
  37. Tokuda S., Kuramoto T., Tanaka K., Kaneko S., Takeuchi I.K., Sasa M., Serikawa T. The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures. Brain Res., 1133, 168-177 (2007)
  38. Kume ., Taguchi R., Katsuki H., Akao M., Sugimoto H., Kaneko S., Akaike A. Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation. Eur. J. Pharmacol., 542, 69-76 (2006)
  39. Fukui M., Nakagawa T., Minami M., Satoh M., Kaneko S. Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats. Mol. Pain, 2, 19 (2006)
  40. Kaneko S., Kawakami S., Hara Y., Wakamori M., Itoh E., Minami T., Takada Y., Kume K., Katsuki H., Mori Y., Akaike A.. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J. Pharmacol. Sci., 101, 66-76 (2006)
  41. Shirakawa H., Katsuki H., Kume T., Kaneko S., Akaike A. Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons. Br. J. Pharmacol., 147, 729-736 (2006)
  42. Yazaki K., Yamanaka N., Masuno T., Konagai S., Shitan N., Kaneko S., Ueda K., Sato F. Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation. Plant. Mol. Biol., 61, 491-503 (2006)
  43. Kinoshita-Kawada M., Tang J., Xial R., Kaneko S., Foskett J.K., Zhu M.X. Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch. Eur. J.Physiol. 450, 345-354 (2005)
  44. Fujio M., Nakagawa T., Suzuki Y., Satoh M., Kaneko S. Facilitative effect of a glutamate transporter inhibitor (2S,3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate on the expression of methamphetamine-induced behavioral sensitization in rats. J. Pharmacol. Sci., 99, 415-418 (2005)
  45. Fujio M., Nakagawa T., Sekiya Y., Ozawa T., Suzuki Y., Minami M., Satoh M., Kaneko S. Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats. Eur. J. Neurosci.,22, 2744-2754 (2005)
  46. Nakagawa T., Yamamoto R., Fujio M., Suzuki S., Minami M., Satoh M., Kaneko S. Involvement of the bed nucleus of the stria terminalis activated by the central nucleus of the amygdala in the negative affective component of morphine withdrawal in rats. Neuroscience, 134, 9-19 (2005)
  47. Shirakawa H., Katsuki H., Kume T., Kaneko S., Akaike A. Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons. Eur. J. Neurosci., 21, 2329-2335 (2005)
  48. Toyohara H., Yamamoto S., Hosoi M., Takagi M., Hayashi I., Nakao K., Kaneko S. Scallop DMT functions as a Ca2+ transporter. FEBS Lett., 579, 2727-2730 (2005)
  49. Osakada F., Hashino A., Kume T., Katsuki H., Kaneko S., Akaike A. alpha-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology, 47, 904-915 (2004)
  50. Fujimoto S., Katsuki H., Kume T., Kaneko S., Akaike A. Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures. Neurosci. Res., 50, 179-187 (2004)
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原著論文（2003年以前）
  1. Noriko Sakka, Hideyuki Sawada, Yasuhiko Izumi, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko, Shun Shimohama, Akinori Akaike. Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. Neuroreport, 14, 2425-2428 (2003)
  2. Feng Wang, Nobuya Matsuoka, Seitaro Mutoh and Shuji Kaneko. Modulation of Ca2+ channel currents by a novel anti-dementia drug FK960 in rat hippocampal neurons. J. Pharmacol. Exp. Ther., 308, 120-126 (2003)
  3. Yuki Takada, Atsushi Yonezawa, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko, Hachiro Sugimoto and Akinori Akaike. Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. J. Pharmacol. Exp. Ther., 306, 772-777 (2003)
  4. Haruki Shibata, Hiroshi Katsuki, Mayumi Nishiwaki, Toshiaki Kume, Shuji Kaneko and Akinori Akaike. Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin. J. Neurochem. 86, 1201-1212 (2003)
  5. Ryota Taguchi, Hiroyuki Nishikawa, Toshiaki Kume, Taro Terauchi, Shuji Kaneko, Hiroshi Katsuki, Masahiro Yonaga, Hachiro Sugimoto and Akinori Akaike. Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons. Eur. J. Pharmacol., 477, 195-203 (2003)
  6. Fumitaka Osakada, Asami Hashino, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko and Akinori Akaike. Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures. Eur. J. Pharmacol., 465, 15-22 (2003)
  7. Hiroshi Katsuki, Haruki Shibata, Chikako Takenaka, Toshiaki Kume, Shuji Kaneko, Akinori Akaike. N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures. Neurosci. Lett., 341, 123-126 (2003)
  8. Shuji Kaneko, Conan B. Cooper, Naoto Nishioka, Hironobu Yamasaki, Atsushi Suzuki, Scott E. Jarvis, Akinori Akaike, Masamichi Satoh and Gerald W. Zamponi. Identification and characterization of novel human Cav2.2 (alpha1B) calcium channel variants lacking the synaptic protein interaction site. J. Neurosci., 22, 82-92 (2002)
  9. Hiroyuki Tabata, Satoshi Tanaka, Yukihiko Sugimoto, Hideaki Kanki, Shuji Kaneko and Atsushi Ichikawa. Possible coupling of prostaglandin E receptor EP1 to TRP5 expressed in Xenopus laevis oocytes. Biochem. Biophys. Res. Commun., 298, 398-402 (2002)
  10. Toshiaki Kume, Hiroyuki Nishikawa, Ryota Taguchi, Asami Hashino, Hiroshi Katsuki, Shuji Kaneko, Masabumi Minami, Masamichi Satoh and Akinori Akaike. Antagonism of NMDA receptors by s receptor ligands attenuates chemical ischemia-induced neuronal death in vitro. Eur. J. Pharmacol., 455, 91-100 (2002)
  11. Kohei Yoshida, Takayuki Nakagawa, Shuji Kaneko, Akinori Akaike and Masamichi Satoh. Adenosine 5’-triphosphate inhibits slow depolatization induced by repetitive dorsal root stimulation via P2Y purinoceptors in substantia gelatinosa neurons of the adult rat spinal cord slices with the dorsal root attached. Neurosci. Lett., 320, 121-124 (2002)
  12. Toshiaki Kume, Naoki Asai, Hiroyuki Nishikawa, Nariyasu Mano, Taro Terauchi, Hisashi Shirakawa, Fumitaka Osakada, Naoki Asakawa, Masahito Yonaga, Yukio Nishizawa, Hachiro Sugimoto, Shun Shimohama, Hiroshi Katsuki, Shuji Kaneko and Akinori Akaike. Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum. Proc. Natl. Acad. Sci. U.S.A., 99, 3288-3293 (2002)
  13. Hisashi Shirakawa, Hiroshi Katsuki, Toshiaki Kume, Shuji Kaneko, Juichi Ito, Akinori Akaike. Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons. Eur. J. Pharmacol., 454, 165-175 (2002)
  14. Hideaki Kanki, Mariko Kinoshita, Akinori Akaike, Masamichi Satoh, Yasuo Mori and Shuji Kaneko, Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels, Mol. Pharmacol., 60, 989-998 (2001)
  15. Mariko Kinoshita, Toshihide Nukada, Tomiko Asano, Yasuo Mori, Akinori Akaike, Masamichi Satoh and Shuji Kaneko, Binding of Gαo is responsible for the voltage-resistant inhibition of α1A (P/Q-type, Cav2.1) Ca2+ channels, J. Biol. Chem., 276, 28731-28738 (2001)
  16. Hiroshi Katsuki, Michiko Tomita, Chikako Takenaka, Hisashi Shirakawa, Seiichiro Shimazu, Masakazu Ibi, Toshiaki Kume, Shuji Kaneko and Akinori Akaike, Superoxide dismutase activity in organotypic midbrain-striatum co-culture is associated with resistance of dopaminergic neurons to excitotoxicity, J. Neurochem., 76, 1336-1345 (2001)
  17. Hiroshi Katsuki, Chikako Takenaka, Toshiaki Kume, Shuji Kaneko and Akinori Akaike, Requirement of neural activity for the maintenance of dopaminergic neurons in rat midbrain slice cultures, Neurosci. Lett., 300, 166-170 (2001)
  18. Masakazu Ibi, Hideyuki Sawada, Miki Nakanishi, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko, Shun Shimohama, Akinori Akaike. Protective effects of 1a,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology, 40, 761-771 (2001)
  19. Mariko Kinoshita, Akinori Akaike, Masamichi Satoh and Shuji kaneko, Positive regulation of capacitative Ca2+ entry by intracellylar Ca2+ in Xenopus oocytes expressing rat TRP4, Cell Calcium, 28, 151-159 (2000)
  20. Hiroyuki Nishikawa, Asami Hashino, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko and Akinori Akaike, Involvement of direct inhibition of NMDA receptors in the effects of σ-receptor ligands on glutamate neurotoxicity in vitro, Eur. J. Pharmacol., 404, 41-48 (2000)
  21. Toshiaki Kume, Hiroyuki Nishikawa, Hiroko Tomioka, Hiroshi Katsuki, Akinori Akaike, Shuji Kaneko, Takehiko Maeda, Takeshi Kihara and Shun Shimohama, p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures, Brain Res., 852, 279-289 (2000)
  22. Seiichiro Shimazu, Hiroshi Katsuki, Chikako Takenaka, Michiko Tomita, Toshiaki Kume, Shuji Kaneko and Akinori Akaike, σ receptor ligands attenuate N-methyl-D-aspartate cytotoxicity domaminergic neurons of mesencephalic slice cultures, Eur. J. Pharmacol., 388, 139-146 (2000)
  23. Kiyoshi Mizukami, Shuntaro Kounomi, Shuji Kaneko and Masamichi Satoh, Some physiological and pharmacological properties of slow depolarization of substantia gelatinosa neurons by repetitive stimulation of C-fibers of dorsal root in adult rat spinal cord slices with dorsal root attached, Neurosci. Lett., 274, 49-52 (1999)
  24. Masakazu Ibi, Hideyuki Sawada, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko, Shun Shimohama and Akinori Akaike, Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalic dopaminergic neurons, J. Neurochem., 73, 1696-1703 (1999)
  25. Katsuyuki Kaneda, Satoshi Kashii, Takayuki Kurosawa, Shuji Kaneko, Akinori Akaike, Toshihito Honda, Masabumi Minami, Masamichi Satoh, Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina, Brain Res., 815, 11-20 (1999)
  26. Einosuke Sakurai, Tsutomu Hashikawa, Yoshihiro Yoshihara, Shuji Kaneko, Masamichi Satoh and Kensaku Mori, Involvement of dendritic adhesion molecule telencephalin in hippocampal long-term potentiation, NeuroReport, 9, 881-886 (1998)
  27. Mariko Kinoshita, Shuji Kaneko, Tohru Yasuno, Nobumichi Yada, Akinori Akaike and Masamichi Satoh, Inhibitory effects of bifemelane on brain Ca2+ channel subtypes expressed in Xenopus oocytes, Jpn. J. Pharmacol., 78, 39-44 (1998)
  28. Yasuhiko Tomita, Shuji Kaneko, Michitaka Funayama, Hisatake Kondo, Masamichi Satoh and Akinori Akaike, Intracellular Ca2+ store-operated influx of Ca2+ through TRP-R, a rat homolog of TRP, expressed in Xenopus oocytes, Neurosci. Lett., 248, 195-198 (1998)
  29. Einosuke Sakurai, Takehiko Maeda, Shuji Kaneko, Akinori Akaike and Masamichi Satoh, Inhibition by [Arg8]-vasopressin of long term potentiation in guinea pig hippocampal slice, Jpn. J. Pharmacol., 77, 103-105 (1998)
  30. Shuji Kaneko, Akinori Akaike and Masamichi Satoh, Differential regulation of N- and Q-type Ca2+ channels by cyclic nucleotides and G-proteins, Life Sci., 62, 1543-1547 (1998)
  31. Toshiaki Kume, Hanae Kouchiyama, Satoshi Kaneko, Takehiko Maeda, Shuji Kaneko, Akinori Akaike, Shun Shimohama, Takeshi Kihara, Jun Kimura, Kazuyo Wada and Shinichi Koizumi, BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons, Brain Res., 756, 200-204 (1997)
  32. Shuji Kaneko, Nobumichi Yada, Koichiro Fukuda, Masanobu Kikuwaka, Akinori Akaike and Masamichi Satoh, Inhibition of Ca2+ channel current by mu- and kappa-opioid receptors coexpressed in Xenopus oocytes: desensitization depending on Ca2+ channel alpha1 subunits, Br. J. Pharmacol., 121, 806-812 (1997)
  33. Takehiko Maeda, Shuji Kaneko, Akinori Akaike and Masamichi Satoh, Direct evidence for increase in excitatory amino acids release during mossy fiber LTP in rat hippocampal slices as revealed by the patch sensor methods, Neurosci. Lett., 224, 103-106 (1997)
  34. Toshiaki Kume, Hanae Kohchiyama, Hiroyuki Nishikawa, Takehiko Maeda, Shuji Kaneko, Akinori Akaike, Naoki Noda and Tetsuro Fujita, Ether extract of Fetal calf serum protects cultured rat cortical neurons against glutamate cytotoxicity, Jpn. J. Pharmacol., 73, 371-374 (1997)
  35. Katsuyuki Kaneda, Masashi Kikuchi, Satoshi Kashii, Yoshihito Honda, Takehiko Maeda, Shuji Kaneko and Akinori Akaike, Effects of B vitamins on glutamate-induced neurotoxicity in retinal cultures, Eur. J. Pharmacol., 322, 259-264 (1997)
  36. Yukinori Shimoshige, Takehiko Maeda, Shuji Kaneko, Akinori Akaike and Masamichi Satoh, Involvement of M2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices, Neurosci. Res., 27, 175-180 (1997)
  37. Shuji Kaneko, Takehiko Maeda, Masamichi Satoh, Cognitive enhancers and hippocampal long-term potentiation in vitro, Behav. Brain Res., 83, 45-49 (1997)
  38. Einosuke Sakurai, Takehiko Maeda, Shuji Kaneko, Akinori Akaike and Masamichi Satoh, Galanin inhibits long-term potentiation at Schaffer collateral-CA1 synapses in guinea-pig hippocampal slices, Neurosci. Lett., 212, 21-24 (1996)
  39. Koichiro Fukuda, Shuji Kaneko, Nobumichi Yada, Akinori Akaike and Masamichi Satoh, Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes, Neurosci. Lett., 217, 13-16 (1996)
  40. Takehiko Maeda, Yukinori Shimoshige, Kiyoshi Mizukami, Shun Shimohama, Shuji Kaneko, Akinori Akaike and Masamichi Satoh, Patch sensor detection of glutamate release evoked by a single electrical shock, Neuron 15, 253-257 (1995)
  41. Akinori Akaike, Shuji Kaneko, Yutaka Tamura, Noritaka Nakata, Hirohito Shiomi, Fumitaka Ushikubi and Shuh Narumiya, Prostaglandin E2 protects cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity, Brain Res., 663, 237-243 (1994)
  42. Takehiko Maeda, Shuji Kaneko and Masamichi Satoh, Roles of endogenous cholinergic neurons in the induction of long-term potentiation at hippocampal mossy fiber synapses, Neurosci. Res., 20, 71-78 (1994)
  43. Shunichi Nakamura, Shuji Kaneko and Masamichi Satoh, Potentiation of AMPA-selective glutamate receptor function by a nootropic drug, idebenone, Biol. Pharm. Bull. 17, 70-73 (1994)
  44. Shuji Kaneko, Shunichi Nakamura, Kei Adachi, Akinori Akaike, and Masamichi Satoh, Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by kappa opioid receptors expressed in Xenopus oocytes, Mol. Brain Res., 27, 258-264 (1994)
  45. Shuji Kaneko, Koichiro Fukuda, Nobumichi Yada, Akinori Akaike, Yasuo Mori and Masamichi Satoh, Ca2+ channel inhibition by kappa opioid receptors expressed in Xenopus oocytes, NeuroReport, 5, 2506-2508 (1994)
  46. Takehiko Maeda, Shuji Kaneko and Masamichi Satoh, Inhibitory influence via 5-HT3 receptors on the induction of LTP in mossy fiber-CA3 system of guinea pig hippocampal slices, Neurosci. Res., 18, 277-282 (1994)
  47. Shuji Kaneko, Junichi Yuasa, Hideki Takahashi and Masamichi Satoh, Functional expression of Ca2+-mobilizing opioid receptors in Xenopus oocytes injected with rat brain mRNA, Mol. Brain Res., 22, 69-75 (1994)
  48. Miwako Ozaki, Kiyoshi Matsumura, Shuji Kaneko, Masamichi Satoh, Yasuyoshi Watanabe and Toshifumi Aoyama, A vaccinia virus vector for efficiently introducing into hippocampal slices, Biochem. Biophys. Res. Commun., 193, 653-660 (1993)
  49. Takehiko Maeda, Shuji Kaneko and Masamichi Satoh, Bidirectional modulation of long-term potentiation by carbachol via M1 and M2 muscarinic receptors in guinea pig hippocampal mossy fiber-CA3 synapse, Brain Res., 619, 324-330 (1993)
  50. Masabumi Minami, Takashi Toya, Yasutoshi Katao, Kyoko Maekawa, Shunichi Nakamura, Tatsuo Onogi, Shuji Kaneko and Masamichi Satoh, Cloning and expression of a cDNA for rat kappa-opioid receptor, FEBS Lett., 329, 291-295 (1993)
  51. Hiroshi Katsuki, Shuji Kaneko and Masamichi Satoh, Involvement of postsynaptic G proteins in hippocampal long-term potentiation, Brain Res., 581, 108-114 (1992)
  52. Shuji Kaneko, Hideki Takahashi and Masamichi Satoh, Metabotropic responses to acetylcholine and serotonin of Xenopus oocytes injected with rat brain mRNA are transduced by different G-protein subtypes, FEBS Lett., 299, 179-182 (1992)
  53. Ryohei Hori, Midori Hirai, Toshiya Katsura, Mikihisa Takano, Masato Yasuhara, Shuji Kaneko and Masamichi Satoh, Expression of renal organic cation transporter in Xenopus oocytes, Biochem. J., 283, 409-411 (1992)
  54. Nobuya Matsuoka, Shuji Kaneko and Masamichi Satoh, A facilitatory role of endogenous somatostatin in long-term potentiation of the mossy fiber-CA3 system in guinea-pig hippocampus, Neurosci. Lett., 129, 177-180 (1991)
  55. Nobuya Matsuoka, Shuji Kaneko and Masamichi Satoh, Somatostatin augments long-term potentiation of the mossy fiber-CA3 system in guinea-pig hippocampal slices, Brain Res., 553, 188-194 (1991)
  56. Hiroshi Katsuki, Shuji Kaneko, Atsushi Tajima and Masamichi Satoh, Separate mechanisms of long-term potentiation in two input systems to CA3 pyramidal neurons of rat hippocampal slices as revealed by the whole-cell patch-clamp technique, Neurosci. Res., 12, 393-402 (1991)
  57. Kumatoshi Ishihara, Hiroshi Katsuki, Masunobu Sugimura, Shuji Kaneko and Masamichi Satoh, Different drug-susceptibilities of long-term potentiation in three input systems to the CA3 region of the guinea pig hippocampus in vitro, Neuropharmacology, 29, 487-492 (1990)
  58. Shuji Kaneko, Masunobu Sugimura, Tatsuo Inoue and Masamichi Satoh, Effects of several cerebroprotective drugs on NMDA channel function: evaluation using Xenopus oocytes and [3H]MK-801 binding, Eur. J. Pharmacol., 207, 119-128 (1991)
  59. Shuji Kaneko, Masunobu Sugimura and Masamichi Satoh, Interspecies differences in the population of multiple glutamate receptors expressed in Xenopus oocytes after injection of guinea pig, mouse and rat forebrain mRNAs, Neurosci. Lett., 117, 134-139 (1990)
  60. Shuji Kaneko, Hideki Takahashi and Masamichi Satoh, The use of Xenopus oocytes to evaluate drugs affecting brain Ca2+ channels: effects of bifemelane and several nootropic agents, Eur. J. Pharmacol., 189, 51-58 (1990)
  61. Shuji Kaneko, Emiko Doi, Hiroshi Watanabe and Yasuyuki Nomura, A long-lasting potentiation of calmodulin-mediated chloride channel activity without a mediation of protein kinase C in Xenopus oocytes injected with rat brain mRNA, Cell Calcium, 11, 309-317 (1990)
  62. Yasuyuki Nomura, Beng -X. Wang, Shang -B. Qi, Tsuneo Namba and Shuji Kaneko. Biochemical changes related to aging in the senescence-accelerated mouse. Exp. Gerontol., 24, 49-55 (1989)
  63. Masao Hattori, Xie -W. Yang, Shuji Kaneko, Yasuyuki Nomura and Tsuneo Namba. Constituents of the pilose antler of Cervus nippon var. mantchuricus. Shoyakugaku Zasshi, 43, 173-176 (1989)
  64. Kenichi Kato, Shuji Kaneko and Yasuyuki Nomura. Phorbol ester inhibition of current responses and simultaneous protein phosphorylation in Xenopus oocyte injected with brain mRNA. J. Neurochem., 50, 766-773 (1988)
  65. Isao Ito, Chikara Hirono, Shunichi Yamagishi, Yasuyuki Nomura, Shuji Kaneko and Hiroyuki Sugiyama. Roles of protein kinases in neurotransmitter responses in Xenopus oocytes injected with rat brain mRNA. J. Cell. Physiol., 84, 155-160 (1988)
  66. Beng -X. Wang, Xue -H. Zhao, Shang -B. Qi, Shuji Kaneko, Masao Hattori, Tsuneo Namba and Yasuyuki Nomura. Effects of repeated administration of deer antler extract on biochemical changes related to aging in senescence-accelerated mice. Chem. Pharm. Bull., 36, 2587-2592 (1988)
  67. Beng -X. Wang, Xue -H. Zhao, Shang -B. Qi, Xiu -W. Yang, Shuji Kaneko, Masao Hattori, Tsuneo Namba and Yasuyuki Nomura. Stimulating effect of deer antler extract on protein synthesis in senescence-accelerated mice in vivo. Chem. Pharm. Bull., 36, 2593-2598 (1988)
  68. Kazuo Sasaki, Hiroshi Suda, Hiroshi Watanabe, Shuji Kaneko, Yasuyuki Nomura, Hitoo Nishino and Taketoshi Ono. Habenular lesion attenuates methamphetamine-induced inhibition of dopamine neuronal activity in the substantia nigra pars compacta of rats. Neurosci. Lett., 86, 67-71 (1988)
  69. Shuji Kaneko, Kenichi Kato, Shunichi Yamagishi, Hiroyuki Sugiyama and Yasuyuki Nomura. GTP-binding proteins Gi and Go transplanted onto Xenopus oocyte by rat brain messenger RNA. Mol. Brain Res., 3, 11-19 (1987)
  70. Shuji Kaneko and Yasuyuki Nomura, Cyclic AMP facilitates slow-inactivating Ca2+ channel currents expressed by Xenopus oocyte after injection of rat brain mRNA. Neurosci. Lett., 83, 123-127 (1987)
  71. Yasuyuki Nomura, Shuji Kaneko, Kenichi Kato, Shunichi Yamagishi and Hiroyuki Sugiyama. Inositol phosphate formation and chloride current responses induced by acetylcholine and serotoninn through GTP-binding proteins in Xenopus oocyte after injection of rat brain messenger RNA. Mol. Brain Res., 2, 113-123 (1987)
  72. 馬永華, 葉加南, 服部征雄, 金子周司, 野村靖幸, 倉茂洋一, 若木邦彦, 堀越勇, 難波恒雄．脾虚証病態モデル動物の研究（I）センナ長期投与ラットの病態学的変化．和漢医薬学会誌, 4, 138-148 (1987)
  73. 馬永華, 葉加南, 服部征雄, 金子周司, 野村靖幸, 倉茂洋一, 若木邦彦, 難波恒雄．杜仲葉の研究（IV）センナ長期投与による虚弱ラットへの杜仲葉水エキスの影響について． 和漢医薬学会誌, 4, 180-191 (1987)
  74. 馬永華, 葉加南, 服部征雄, 金子周司, 野村靖幸, 若木邦彦, 倉茂洋一, 難波恒雄．杜仲葉の研究（II）杜仲葉水エキス長期投与によるラットへの影響について．和漢医薬学会誌, 4, 26-34 (1987)
  75. 難波恒雄, 服部征雄, 葉加南, 馬永華, 野村靖幸, 金子周司, 北村佳久, 小泉保, 片山和憲, 爐韋．杜仲葉の研究（I）水抽出画分の一般薬理作用．和漢医薬学会誌, 3, 89-97 (1986)
  76. Yasushi Kuraishi, Naoyoshi Hirota, Yoichi Sato, Shuji Kaneko, Masamichi Satoh and Hiroshi Takagi. Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn. Brain Res., 359, 177-182 (1985)
  77. Shuji Kaneko, Akihisa Mori, Shigeki Tamura, Masamichi Satoh and Hiroshi Takagi. Intracerebroventricular administration of angiotensin II attenuates morphine-induced analgesia in mice. Neuropharmacology, 24, 1131-1134 (1985)
  78. Shuji Kaneko, Shigeki Tamura and Hiroshi Takagi. Purification and identification of endogenous anti-opioid substances from bovine brain. Biochem. Biophys. Res. Commun., 126, 587-593 (1985)
  79. Hiro Amano, Yasuo Morimoto, Shuji Kaneko and Hiroshi Takagi. Opioid activity of enkephalin analogues containing the kyotorphin-related structure in the N-terminus. Neuropharmacology, 23, 395-400 (1984)
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