最近の論文
2017

Yasui, M.; Ota, R.; Tsukano, C.*; Takemoto, Y.* Total synthesis of avenaol, Nat. Commun., 2017, 8, 674. DOI:10.1038/s41467-017-00792-1


Kurose, T.; Tsukano, C.; Takemoto, Y. Synthesis of Octahydro- and Decahydroquinolines by a One-Pot Cascade Reaction of Tetrasubstituted Enecarbamate, Org. Lett., 2017, 19, 4762. DOI:10.1021/acs.orglett.7b02122

Electrophilic Activation of Iodonium Ylides by Halogen-Bond-Donor Catalysis for Cross-Enolate Coupling, Saito, M.; Kobayashi, Y.; Tsuzuki, S.; Takemoto, Y. Angew. Chem. Int. Ed. 2017, 56, 7653. DOI:10.1002/anie.201703641
同誌のVery Important Paperに選出されました



Enantioselective Synthesis of anti-β-Hydroxy-α-amino Esters via an Organocatalyzed Decarboxylative Aldol Reaction, Taryn, M.; Murata, A.; Kobayashi, Y.; Takemoto, Y. Synlett, 2017, 28, 1295.DOI:10.1055/s-0036-1588141



2016

An Enantioselective Synthesis of 2-Imidazolidinones through Bifunctional Thiourea-Catalyzed Tandem Mannich/Cyclization of Isocyanatomalonate Diester, Kobayashi Y.;, Yoshida, T.; Uno, Y.; Tsukano, C.; Takemoto, Y. Heterocycles, 2017, 95, 980.DOI:10.3987/COM-16-S(S)68



Competent route to the unsymmetric dimer architectures: Total syntheses of (-)-lycodine, (-)-complanadines A and B, and evaluation of their neurite outgrowth activities, Zhao, L.; Tsukano, C.; Kwon, E.; Shirakawa, H.; Kaneko, S.; Takemoto, S.; Hirama, M. Chem. Eur. J. 2017,23, 802.同誌のVery Important Paperに選出されましたDOI:10.1002/chem.201604647



Nanjo, T.; Tsukano, C.; Takemoto, Y., Palladium-Catalyzed Double C-H Functionalization of Arenes at the Positions ortho and meta to their Directing Group: Concise Synthesis of Benzocyclobutenes, Chem. Pharm. Bull. 64, 1384-1392 (2016).DOI:10.1248/cpb.c16-00439


45
Chiral Integrated Catalysts Composed of Bifunctional Thiourea and Arylboronic Acid: Asymmetric Aza-Michael Addition of α,β-Unsaturated Carboxylic Acids, Noboru Hayama, Takumi Azuma, Yusuke Kobayashi, Yoshiji Takemoto, Chem. Pharm. Bull. 2016, 64, 704. DOI:10.1248/cpb.c15-00983


Synthesis and Application of Tetrahydro-2H-fluorenes by a Pd(0)-Catalyzed Benzylic C(sp3)-H Functionalization, Satoshi Suetsugu, Nobusuke Muto, Misa Horinouchi, Dr. ChihiroTsukano, Prof.Dr. Yoshiji Takemoto, Chem. Eur. J. 2016, 22, 8059.DOI: 10.1002/chem.201601086

Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide, Hugh Nakamura, Takuma Yoshida, Chihiro Tsukano, Yoshiji Takemoto, Org. Lett. 2016, 18, 2300.DOI: 10.1021/acs.orglett.6b00943


Catalytic Asymmetric Synthesis of anti-α,β-Diamino Acid Derivatives, Sanae Izumi, Yusuke Kobayashi, Yoshiji Takemoto, Org. Lett. 2016, 18, 696.DOI: 10.1021/acs.orglett.5b03666

2015

Catalytic asymmetric formal synthesis of beraprost, Yusuke Kobayashi, Ryuta Kuramoto, Yoshiji Takamoto, Beilstein J. Org. Chem. 2015, 11, 2654. DOI: 10.3762/bjoc.11.285


Synthetic Studies towards Communesins: Diastereoselective Oxidative Rearrangement of Aurantioclavine Derivatives, Satoshi Suetsugu, Chihiro Tsukano, Yoshiji Takemoto, Eur. J. Org. Chem. 2016, 108. DOI: 10.1002/ejoc.201501194


Synthesis of α-Acyloxyketone Derivatives via the Platinum-Catalyzed Migration of Propargylic Esters, Chihiro, Tsukano, Sho, Yamamoto, Yoshiji Takemoto, Chem. Pharm. Bull. 63, 710-719 (2015). DOI: 10.1248/cpb.c15-00417

Direct Dehydroxylative Coupling Reaction of Alcohols with Organosilanes through Si-X Bond Activation by Halogen Bonding, Masato Saito, Nobuya Tsuji, Dr. Yusuke Kobayashi, Prof. Yoshiji Takemoto, Org. Lett. 2015, 17, 3000. DOI: 10.1021/acs.orglett.5b01290


Total Synthesis of (-)-Caprazamycin A, Hugh Nakamura, Dr. Chihiro Tsukano, Motohiro Yasui, Shinsuke Yokouchi, Dr. Masayuki Igarashi and Prof. Dr. Yoshiji Takemoto. Angew. Chem. Int. Ed. 2015, 54, 3136. DOI: 10.1002/anie.201411954


2014

Synthetic Approaches to Spiro-oxindoles and Iminoindolines Based on Formation of C2-C3 Tsukano, C.; Takemoto, Y. Heterocycles, 2014, 89, 2271. DOI: 10.3987/REV-14-805, KURENAI


Electrophilic iodine(I) compounds induced semipinacol rearrangement via C-X bond cleavage, Nobuya Tsuji, Dr. Yusuke Kobayashi, and Prof. Yoshiji Takemoto, Chem. Commun., 2014, 50, 13691. DOI: 10.1039/C4CC06014H


Catalytic asymmetric synthesis of the pentacyclic core of (-)-nakadomarin A via oxazolidine as an iminium cation equivalent, Nobuya Tsuji, Micheal Stadler, Naoya Kazumi, Dr. Tsubasa, Inokuma, Dr. Yusuke Kobayashi, and Prof. Yoshiji Takemoto, Org. Biomol. Chem., 2014, 12, 7919. DOI: 10.1039/C4OB01678E


Asymmetric Synthesis of Trisubstituted Oxazolidinones by the Thiourea-Catalyzed Aldol Reaction of 2-Isocyanatomalonate Diester, Shota sakamoto, Naoya Kazumi, Dr. Yusuke Kobayashi, Dr. Chihiro Tsukano, and Prof. Yoshiji Takemoto, Org. Lett., 2014, 16, 4758. DOI: 10.1021/ol502198e


Synthesis of Pyrrolophenanthridine Alkaloids Based on C(sp3)-H and C(sp2)-H Functionalization Reactions, Dr. Chihiro Tsukano, Nobusuke Muto, Iderbat Enkhtaivan, Prof. Yoshiji, Takemoto, Chem. Asian J. 2014, 9, 2628. DOI: 10.1002/asia.201402490


A Dual Arylboronic Acid-Aminothiourea Catalytic System for the Asymmetric Intramolecular Hetero-Michael Reaction of α,β-Unsaturated Carboxylic Acids, Takumi Azuma, Akihiro Murata, Yusuke Kobayashi, Tsubasa Inokuma, and Yoshiji Takemoto, Org. Lett., 2014, 16(16), 4256-4259 DOI: 10.1021/ol501954r


Synthesis of 3,3-disubstituted indoline-2-thiones catalysed by an N-heterocyclic carbene, Hideo Ikota, Takayuki Ishida, Chihiro Tsukano and Yoshiji Takemoto, Chem. Commun., 2014, 50, 8871-8874 DOI: 10.1039/C4CC04047C



Equilibration of the [2+2] Cycloaddition of Silyl Enol Ethers Catalyzed by Ethylaluminium Dichloride: Diastereoselectivity Switch in the Synthesis of Fused Cyclobutanes, Kenji Hata, Norihito Arichi, Dr. Yousuke Yamaoka, Dr. Ken-ichi Yamada, Prof.Dr. Yoshiji Takemoto and Prof.Dr. Kiyosei Takasu, Asian. J. Org. Chem., 2014, 3(6), 706 DOI: 10.1002/ajoc.201402042



Palladium(0)-Catalyzed Carbon-Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones, Chihiro Tsukano, Masataka Okuno, Hiromi Nishiguchi and Yoshiji Takemoto, Adv. Synth. Catal., 2014, 356(7), 1533 DOI: 10.1002/adsc.201400078



Synthesis of 3,3-Disubstituted 2-Aminoindolenines by Palladium-Catalyzed Allylic Amidination with Isocyanide, Takeshi Nanjo, Chihiro Tsukano, Yoshiji Takemoto, Synlett, 2014, 25(10), 1473 DOI: 10.1055/s-0033-1341241



Oxidant-Resistant Hydrogen-Bond-Donating Organocatalyst for Enantioselective Nucleophilic Epoxidation of α,β-Unsaturated Amides, Yusuke Kobayashi, Shanji Li, Yoshiji Takemoto, Asian. J. Org. Chem., 2014, 3(4), 403 DOI:10.1002/ajoc.201400031



A diversity-oriented synthesis of caroverine derivatives via TEMPO-promoted aerobic oxidative C-N bond formation, Yusuke Kobayashi, Yusuke Suzuki, Tokutaro Ogata, Tetsutaro Kimachi, Yoshiji Takemoto, Tetrahedron Lett., 2014, 55(22), 3299 DOI: 10.1016/j.tetlet.2014.03.061



Synthetic Study of Matrine-Type Alkaloids: Stereoselective Construction of the AB Rings of the Quinolizidine Skeleton, Chihiro Tsukano, Atsuko Oimura, Iderbat Enkhtaivan, Yoshiji Takemoto, Synlett, 2014, 25, 653-656 DOI: 10.1055/s-0033-1340179



Synthesis and Characterization of Binary-Complex Models of Ureas and 1,3-Dicarbonyl Compounds: Deeper Insights into Reaction Mechanisms Using Snap-Shot Structural Analysis, Takumi Azuma, Yusuke Kobayashi, Ken Sakata, Takahiro Sasamori, Norihiro Tokitoh, Yoshiji Takemoto, J. Org. Chem., 2014, 79 (4), 1805-1817 DOI: 10.1021/jo4028775



Asymmetric Synthesis of (−)-Aurantioclavine via Palladium-Catalyzed Intramolecular Allylic Amination, Satoshi Suetsugu, Hiromi Nishiguchi, Chihiro Tsukano, Yoshiji Takemoto, Org. Lett., 2014, 16 (3), 996-999. DOI: 10.1021/ol4037314



Long-Term Oral Administration of Hop Flower Extracts Mitigates Alzheimer Phenotypes in Mice, Norio Sasaoka, Megumi Sakamoto, Shoko Kanemori, Michiru Kan, Chihiro Tsukano, Yoshiji Takemoto, Akira Kakizuka., PLOS ONE, 9(1), e87185. DOI: 10.1371/journal.pone.0087185

2013

Dearomatizing Conjugate Addition to Quinolinyl Amidines for the Synthesis of Dehaloperophoramidine through Tandem Arylation and Allylation,Takayuki Ishida, Hideo Ikota, Kei Kurahashi, Chihiro Tsukano, Yoshiji Takemoto, Angew. Chem. Int. Ed., 2013, 52(39), 10204-10207. DOI: 10.1002/anie.201305581



A Powerful Hydrogen-Bond-Donating Organocatalyst for the Enantioselective Intramolecular Oxa-Michael Reaction of α,β-Unsaturated Amides and Esters,Yusuke Kobayashi, Yamato Taniguchi, Noboru Hayama, Tsubasa Inokuma, Yoshiji Takemoto, Angew. Chem. Int. Ed., 2013, 52(39), 11114-11118. DOI: 10.1002/anie.201305492
Synfacts, 2013, 9(11), 1230., DOI: 10.1055/s-0033-1340025
Synfacts, 2014, 10(1), 0006., DOI: 10.1055/s-0033-1340325



Synthesis of 3-Acyl-2-arylindole via Palladium-catalyzed Isocyanide Insertion and Oxypalladation of Alkyne, Takeshi Nanjo, Sho Yamamoto, Chihiro Tsukano, and Yoshiji Takemoto, Org. Lett. 2013, 15, 3754-3757. DOI: 10.1021/ol4016699



Synthesis of Spirooxindoles from Carbamoyl Chlorides via Cyclopropyl Methine C(sp3)-H Activation Using Palladium Catalyst, Chihiro Tsukano, Masataka Okuno, Yoshiji Takemoto, Chem. Lett., 2013, 42, 753-755. DOI:10.1246/cl.130228
複素環骨格を基盤とする新規水素結合供与型有機分子触媒の開発と不斉反応への応用, 小林祐輔, 猪熊翼, 竹本佳司, 有機合成化学協会誌, 2013, 71 (5), 491-502. DOI:10.5059/yukigoseikyokaishi.71.49



Synthetic study of perophoramidine: construction of pentacyclic core structure via SmI2-mediated reductive cyclization, Takayuki Ishida, Yoshiji Takemoto, Tetrahedron, 2013, 69, 4517-4523. DOI:10.1016/j.tet.2013.04.039



pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols, Yuuki Nagamoto, Akira Hattori, Hideaki Kakeya, Yoshiji Takemoto and Kiyosei Takasu, Chem. Commun., 2013, 49, 2622-2624. DOI:10.1039/C3CC39246E



Study of Ring-Opening Reaction of Spiro[5.2]octenes with Aqueous Hydrohalic Acid: Substituent Effect on the Regioselectivity. Y. Nagamoto, Y. Takemoto, K. Takasu, Synlett (24), 120-124 (2013) DOI:10.1055/s-0032-1317745

生合成中間体を想定した二量体型天然物全合成 塚野千尋, 有機合成化学協会誌, 2013, 71, 946-947. DOI: 10.5059/yukigoseikyokaishi.71.946

2012

N-Heterocyclic carbene-catalyzed direct cross-aza-benzoin reaction: Efficient synthesis of α-amino-β-keto esters, Takuya Uno, Yusuke Kobayashi, Yoshiji Takemoto, Beilstein J. Org. Chem. 2012, 8, 1499-1504 DOI:10.3762/bjoc.8.169



Palladium-Catalyzed Cascade Process Consisting of Isocyanide Insertion and Benzylic C(sp3)-H Activation: Concise Synthesis of Indole Derivatives, Takeshi Nanjo, Chihiro Tsukano, and Yoshiji Takemoto, Org. Lett. 2012, 14, 4270-4273. DOI: 10.1021/ol302035j



Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition?cyclization?trapping reactions, H. Miyabe, R. Asada, Y. Takemoto, Org. Biomol. Chem., 2012, 10, 3519-3530. DOI:10.1039/C2OB25073J



Facile isomerization of silyl enol ethers catalyzed by triflic imide and its application to one-pot isomerization-(2 + 2) cycloaddition, K. Inanaga, Y. Ogawa, Y. Nagamoto, A. Daigaku, H. Tokuyama, Y. Takemoto, K. Takasu, Beilstein J. Org. Chem., 2012, 8, 658-661. DOI:10.3762/bjoc.8.73

Acid-Catalyzed [2 + 2] Cycloaddition at Room-Temperature with Suppression of Side Reactions by Using a Flow Microreactor System. Kei Kurahashi, Yoshiji Takemoto, and Kiyosei Takasu, ChemSusChem 2012, 5 (2), 270-273. DOI: 10.1002/cssc.201100373



Organocatalyzed Isomerization of a-Substituted Alkynoates into Trisubstituted Allenoates by Dynamic Kinetic Resolution, Tsubasa Inokuma, Masaya Furukawa, Yusuke Suzuki, Tetsutaro Kimachi, Yusuke Kobayashi, Yoshiji Takemoto, ChemCatChem 2012, 4, 983-985. DOI: 10.1002/cctc.201200065



Platinum Catalyzed 7-endo Cyclization of Internal Alkynyl Amides and its Application to Synthesis of the Caprazamycin Core, C. Tsukano, S. Yokouchi, A. L. Girard, T. Kuribayashi, S. Sakamoto, T. Enomoto, Y. Takemoto Org. Biomol. Chem., 2012,10, 6074-6086 DOI:10.1039/C2OB25111F



Synthesis of Highly Oxidized Quinolizidine via Reduction of Acylpyridinium Cations, and Total Syntheses of Quinolizidines 207I and 1-epi-207I, C. Tsukano, A. Oimura, I. Enkhtaivan, Y. Takemoto, Org. Lett. 2012, 14 (7), 1902-1905. DOI:10.1021/ol300541u



Palladium-Catalyzed Amidation by Chemoselective C(sp3)H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor. C. Tsukano, M. Okuno, Y. Takemoto, Angew. Chem. Int. Ed., 2012, 51, 2763-2766. DOI:10.1002/anie.201108889



NHC-catalyzed thioesterification of aldehydes by external redox activation. T. Uno, T. Inokuma, Y. Takemoto, Chem. Commun. 2012, 48, 1901-1903. DOI:10.1039/C2CC17183J



Synthesis of 2-Iminoinolines via Samarium Diiodide Mediated Reductive Cyclization of Carbodiimides T. Ishida, C. Tsukano, Y. Takemoto, Chem. Lett., 2012, 41(1), 44-46. DOI:10.1246/cl.2012.44

2011

Organocatalytic Asymmetric Neber Reaction for the Synthesis of 2H-Azirine Carboxylic Esters. S. Sakamoto, T. Inokuma, and Y. Takemoto, Org. Lett., 2011, 13(24), 6374-6377. DOI:10.1021/ol2026747

Synthesis of Optically Active N-Aryl Amino Acid Derivatives through the Asymmetric Petasis Reaction Catalyzed by a Novel Hydroxy-Thiourea Catalyst. T. Inokuma, Y. Suzuki, T. Sakaeda, and Y. Takemoto, Chem. Asian J. 2011, 6, 2902-2906. DOI:10.1002/asia.201100453

Bifunctional Hydrogen-Bond Donors That Bear a Quinazoline or Benzothiadiazine Skeleton for Asymmetric Organocatalysis. T. Inokuma, M. Furukawa, T. Uno, Y. Suzuki, K. Yoshida, Y. Yano, K. Matsuzaki Y. Takemoto, Chem. Eur. J., 2011, 17,(37), 10470-10477. DOI:10.1002/chem.201101338

Formal (3+3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition-Claisen Condensation Accompanied with Isomerization of Silyl Enol Ethers. A. Takumi, T. Yoshiji, T, Kiyosei CHEMICAL & PHARMACEUTICAL BULLETIN 2011, 59 (9), 1190-1193 DOI:10.1248/cpb.59.1190

Regio- and Enantioselective Allylic Substitution with Less Active N- or O-Nucleophiles Catalyzed by Iridium-Complex of Bis(oxazolinyl)pyridine M. Hideto, M. Katsuhiko, T. Yoshiji CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (9), 714-720 DOI:10.1248/cpb.59.714

Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines N. Shindoh, K. Kitaura, Y. Takemoto, K. Takasu, J. Am. Chem. Soc., 2011, 133, 8470-8473 DOI:10.1021/ja202576e

UNPRECEDENTED SYNTHESIS OF N,N-DIVINYLAMINES BY Tf(2)NH-CATALYZED REACTION OF YNAMIDE WITH KETIMINE N. Shindoh, Y. Takemoto, K. Takasu, Heterocycles, 2011, 82(2), 1133 DOI:10.3987/COM-10-S(E)87

Control of 6-Exo and 7-Endo Cyclizations of Alkynylamides using Platinum and Bismuth Catalysts Anne-Lise Girard, Taro Enomoto, Shinsuke Yokouchi, Chihiro Tsukano and Yoshiji Takemoto, Chemistry - An Asian Journal, 2011, 6, 1321-1324 DOI:10.1002/asia.201100209

Domino Pd-Catalyzed Heck-Type Cyclization and Bi-Catalyzed Hydroamination: Formal Syntheses of Elacomine and Isoelacomine. H. Kamisaki, T. Nanjo, C.Tsukano, Y. Takemoto, Chem. Eur. J., 2011, 17,(2), 626-633. DOI:10.1002/chem.201002287

Flexible Strategy for Syntheses of Spirooxindoles using Palladium-catalyzed Carbosilylation and Sakurai-type Cyclization Sudhir M. Hande, Motoyuki Nakajima, Haruhi Kamisaki, Chihiro Tsukano, and Yoshiji Takemoto, Organic Letters 2011, 13(7), 1828-1831. DOI:10.1021/ol2003447

Synthetic studies of salinosporamide A through intramolecular hydroamidation of alkynes. H. Kamisaki, Y. Kobayashi, T. Kimachi, Y. Yasui, Y. Takemoto, J. Organomet. Chem. 2011, 696 (1), 42-45. DOI:10.1016/j.jorganchem.2010.06.021

2010

Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole. K. Takasu, T. Azuma, I. Enkhtaivan, Y. Takemoto, Molecules, 2010, 15, 8327-8348.DOI:10.3390/molecules15118327

Catalytic Asymmetric Synthesis of Both Enantiomers of 4 Substituted 1,4-Dihydropyridines with the Use of Bifunctional Thiourea-Ammonium Salts Bearing Different Counterions. K. Yoshida, T. Inokuma, K. Takasu, Y. Takemoto, Molecules, 2010, 15, 8305-8326.DOI:10.3390/molecules15118305

Auto-tandem Catalysis: Facile Synthesis of Substituted Alkylidenecyclo-hexanones by Domino (4 + 2) Cycloaddition-Elimination Raction. K. Takasu, T. Tanaka, T. Azuma, Y. Takemoto, Chem. Commun., 2010, 46, 8246-8248. DOI:10.1039/C0CC03336G

Stereocontrolled Synthesis of Spiro[n.2]alkenes by Ring Contraction of Fused-Cyclobutanols. K. Takasu, Y. Nagamoto, Y. Takemoto, Chem. Eur. J., 16(28), 8427-8432, (2010). DOI:10.1002/chem.201000930

Synthetic Study toward Ecteinascidin 743: Concise Construction of the Diazabicyclo[3.3.1]nonane Skeleton and Assembly of the Pentacyclic Core. T. Enomoto, Y. Yasui, Y. Takemoto, J. Org. Chem., 75(14), 4876-4879. DOI:10.1021/jo100788j

Synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed intramolecular cyanoamidation. Y. Yasui, H. Kamisaki, T. Ishida, Y. Takemoto, Tetrahedron, 66(10), 1980-1989 (2010). DOI:10.1016/j.tet.2010.01.073

Br?nsted Acid―Thiourea Co-catalysis: Asymmetric Synthesis of Functionalized 1,4-Dihydropyridines from α-Enaminoesters and α,β-Unsaturated Aldehydes. K. Yoshida, T. Inokuma, K. Takasu, Y. Takemoto, Synlett, (12), 1865-1869 (2010). DOI:10.1055/s-0030-1258090

Concise Total Synthesis of (±)-Lycodine. C. Tsukano, L. Zhao, Y. Takemoto, M. Hirama, Eur. J. Org. Chem., (22), 4198-4200, (2010) DOI:10.1002/ejoc.201000667 .

Synthesis of trifunctional thioureas bearing 1,5-disubstituted triazole tether by Ru-catalyzed Huisgen cycloaddition. K. Takasu, T. Azuma, Y. Takemoto, Tetrahedron Lett. 51(20), 2737-2740 (2010). DOI:10.1016/j.tetlet.2010.03.053

Unprecedented Synthesis of N,N-Divinylamines by Tf2NH-Catalyzed Reaction of Ynamide with Ketimine. N. Shindoh, Y. Takemoto, K. Takasu, Heterocycles in press.

Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma. A. Kuwahara, M. Yamamori, K. Nishiguchi, T. Okuno, N. Chayahara, I. Miki, T. Tamura, K. Kadoyama, T. Inokuma, Y. Takemoto, T. Nakamura, K. Kataoka, T. Sakaeda, Int. J. Med. Sci., 7(1), 48-54(2010). DOI

Development of Chiral Thiourea Catalysts and Its Application to Asymmetric Catalytic Reactions. Y. Takemoto, Chem. Pharm. Bull., 58(5), 593-601(2010). DOI

有機ホウ素試薬を利用した不斉チオ尿素触媒反応の開発、竹本佳司、ファインケミカル、2010, 39(8), 22-32.

2009

Hydroxyl Group-Directed Organocatalytic Asymmetric Michael Addition of α,β-Unsaturated Ketones with Alkenylboronic Acids. T. Inokuma, K. Takasu, T. Sakaeda, Y. Takemoto, Org. Lett., 11(11), 2425-2428 (2009). DOI:10.1021/ol9006053

Atropisomerism of .alpha.,.beta.-Unsaturated Amidines: Stereoselective Synthesis by Catalytic Cascade Reaction and Optical Resolution. N. Shindoh, Y. Takemoto, K. Takasu, Chem. Eur. J., 15(29), 7026-7030 (2009). DOI:10.1002/chem.200901103

Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton. Y. Yasui, T. Kinugawa, Y. Takemoto, Chem. Commun., (28), 4275-4277 (2009). DOI:10.1039/B907210A

Gold(I)-Catalyzed Tandem Reactions Initiated by Hydroamination of Alkynyl Carbamates: Application to the Synthesis of Nitidine. T. Enomoto, A.-L. Girard, Y. Yasui, Y. Takemoto, J. Org. Chem., 74(23), 9158-9164 (2009). DOI:10.1021/jo901906b

Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines: Convenient and Direct Modification of Guanidines. H. Miyabe, K. Yoshida, V. K. Reddy, Y. Takemoto, J. Org. Chem., 74(1), 305-311 (2009). DOI:10.1021/jo802271d

Pd-catalyzed intramolecular amidation of 2-(buta-1,3-dienyl)phenylcarbamoyl chloride: a concise synthesis of spiro[indoline-3,3'-pyrrolidine]. H. Kamisaki, Y. Yasui, Y. Takemoto, Tetrahedron Lett., 50(21), 2589-2592 (2009). DOI:10.1016/j.tetlet.2009.03.100

Synthesis of chiral oxime ethers based on regio- and enantioselective allylic substitution catalyzed by iridium-pybox complex. H. Miyabe, A. Matsumura, K. Yoshida, Y. Takemoto, Tetrahedron, 65(23), 4464-4470 (2009). DOI:10.1016/j.tet.2009.04.005

Enantioselective nitrocyclopropanation of .alpha.,.beta.-unsaturated .alpha.-cyanoimides catalyzed by bifunctional thiourea. T. Inokuma, S. Sakamoto, Y. Takemoto, Synlett, (10), 1627-1630 (2009). DOI:10.1055/s-0029-1217331

Preparation of α,β-Unsaturated Lactams through Intramolecular Electrophilic Carbamoylation of Alkenes. Y. Yasui, I. Kakinokihara, H. Takeda, Y. Takemoto, Synthesis, (23), 3989-3993 (2009). DOI:10.1055/s-0029-1217028

Synthesis of indolo[2,3-b]quinolines by palladium-catalyzed annulation of unsaturated isothioureas. H. Takeda, T. Ishida, Y. Takemoto, Chem. Lett., 38(8), 772-773 (2009). DOI:10.1246/cl.2009.772

Asymmetric Synthesis of 4-Substituted 2,6-Dioxopiperidine-3-carbonitrile by Using Thiourea-Catalyzed Asymmetric Michael Addition. T. Inokuma, Y. Nagamoto, S. Sakamoto, H. Miyabe, K. Takasu, Y. Takemoto, Heterocycles, 79(1), 573-582 (2009). DOI:10.3987/COM-08-S(D)18

Triflic Imide Catalyzed [3+2] Cycloaddition of Aldimines with α,α-Dimethylallylsilane. N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu, Heterocycles, 77(1), 187-192 (2009).DOI:10.3987/COM-08-S(F)17

Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma. A. Kuwahara, M. Yamamori, K. Nishiguchi, T. Okuno, N. Chayahara, I. Miki, T. Tamura, T. Inokuma, Y. Takemoto, T. Nakamura, K. Kataoka, T. Sakaeda, Int. J. Med. Sci., 6(6), 305-311 (2009). DOI

Auto-Tandem Catalysis: A Single Catalyst Activating Mechanistically Distinct Reactions in a Single Reactor. N. Shindoh, Y. Takemoto, K. Takasu, Chem. Eur. J., 15(45), 12168-12179 (2009). DOI:10.1002/chem.200901486

Triflic Imide Catalyzed Cycloaddition Reactions. K. Takasu, Synlett, (12), 1905-1914 (2009). DOI:10.1055/s-0029-1217522

インジウムを用いる合成反応の開発. 柳田玲子、竹本佳司, 有機合成化学協会誌, 67(3), 239-247 (2009).

2008

Intra- and Intermolecular Amidation of C-C Unsaturated Bonds Through Palladium-Catalyzed Reactions of Carbamoyl Derivatives. Y. Yasui, Y. Takemoto, Chem. Rec. 8(6), 386-394 (2008).

Toward General Access to the Aspidosperma-Type Terpenoid Indole Alkaloids: Synthesis of the Key 3,3-Disubstituted Piperidones through Enantioselective Intramolecular Heck-Type Reaction of Chloroformamides. Y. Yasui, H. Takeda, Y. Takemoto, Chem. Pharm. Bull. 56 (11), 1567-1574 (2008).

Thiourea-Catalyzed Asymmetric Formal [3 + 2] Cycloaddition of Azomethine Ylides with Nitroolefins. J. Xie, K. Yoshida, K. Takasu, Y. Takemoto, Tetrahedron Lett. 49(48), 6910-6913 (2008).

Discovery and Application of Asymmetric Reaction by Multi-Functional Thioureas. H. Miyabe, Y. Takemoto, Bull. Chem. Soc. Jpn. 81 (7), 785-795 (2008).

Auto-Tandem Catalysis in the Synthesis of Substituted Quinolines from Aldimines and Electron-rich Olefins: Cascade Povarov-Hydrogen Transfer Reaction. N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu, J. Org. Chem. 73(19), 7451-7456 (2008).

Enantioselective Synthesis of 3,3-Disubstituted Oxindoles through Pd-Catalyzed Cyanoamidation. Y. Yasui, H. Kamisaki, Y. Takemoto, Org. Lett. 10 (15), 3303-3306 (2008).

Gold(I)-Catalyzed Hydroamination as a General Approach toward the Synthesis of Substituted Hydroisoquinolines: Remarkable Acceleration by Ethanol. T. Enomoto, S. Obika, Y. Yasui, Y. Takemoto, Synlett (11), 1647-1650 (2008).

連続反応および多成分反応を基盤とする多置換シクロブタンの迅速合成法の開発、高須清誠、有機合成化学協会誌、66 (6), 554-563, 2008.

Concise Synthesis of the CDE Ring System of Tetrahydroisoquinoline Alkaloids Using Carbophilic Lewis Acid-Catalyzed Hydroamidation and Oxidative Friedel-Crafts Cyclization. S. Obika, Y. Yasui, R. Yanada, Y. Takemoto, J. Org. Chem. 73 (13), 5206-5209 (2008).

Indium(III)-Catalyzed Tandem Reaction with Alkynylbenzaldehydes and Alkynylanilines to Heteroaromatic Compounds. R. Yanada, K. Hashimoto, R. Tokizane, Y. Miwa, H. Minami, K. Yanada, M. Ishikura, Y. Takemoto, J. Org. Chem. 73 (13), 5135-5138 (2008).

Enantioselective Synthesis of [1,2]-oxazinone scaffolds and [1,2]-oxazine core structures of FR900482. V. K. Reddy, H. Miyabe, M. Yamauchi, Y. Takemoto, Tetrahedron, 64 (6), 1040-1048 (2008).



2007

Gold-Catalyzed Cyclization Reaction of Alkynyl tert-Butylcarbamates. H. Miyabe, Y. Sami, T. Naito, Y. Takemoto, Heterocyles, 73 (1), 187-190 (2007).

Chiral Thiourea-catalyzed Direct Mannich Reactions. Y. Yamaoka, H. Miyabe, Y. Yasui, Y. Takemoto, Synthesis, 2007 (16), 2571-2575 (2007).

Enantioselective Radical Cyclizations: A New Approach to Stereocontrol of Cascade Reactions. H. Miyabe, Y. Takemoto, Chem. Eur. J., 13 (26), 7280-7286 (2007).

Enantioselective Cascade Radical Addition-Cyclization of Oxime Ethers. H. Miyabe, A. Toyoda, Y. Takemoto, Synlett, 2007 (12), 1885-1888 (2007).

The Amino Thiourea-Catalyzed Asymmetric Nucleophilic Reactions. Y. Takemoto, H. Miyabe, Chimia, 61 (5), 269-275 (2007).

One-Pot Amidation of Olefins through Pd-Catalyzed Coupling of Alkylboranes and Carbamoyl Chlorides. Y. Yasui, S. Tuschida, H. Miyabe, Y. Takemoto, J. Org. Chem., 72 (15), 5898-5900 (2007).

Concise Synthesis of 1,2-Dihydroisoquinolines and 1H-Isochromones by Carbophilic Lewis Acid-Catalyzed Tandem Nucleophilic Addition and Cyclization of 2-(1-Alkynyl)arylaldimines and 2-(1-Alkynyl)aryaldehydes. S. Obika, H. Kono, Y. Yasui, R. Yanada, Y. Takemoto, J. Org. Chem., 72 (12), 4462-4468(2007).

Catalytic Enantioselective Petasis-Type Reaction of Quinolines Catalyzed by a Newly Designed Thiourea Catalyst. Y. Yamaoka, H. Miyabe, Y. Takemoto, J. Am. Chem. Soc, 129 (21), 6686-6687 (2007).

Intramolecular Cyanoamidation of Unsaturated Cyanoformamides Catalyzed by Palladium: An Efficient Synthesis of Multi-Functionalized Lactams. Y. Kobayashi, H. Kamisaki, H. Takeda, Y. Yasui, R. Yanada, Y. Takemoto, Tetrahedron, 63 (14), 2978-2989 (2007).


2006

Development of Amino Thiourea Catalysts as an Artificial Enzyme: Their Application to Catalytic Enantioselective Reactions. Y. Takemoto, J. Synth. Org. Chem. Jpn., 64 (11), 1139-1147 (2006).

C-N Bond Formation through Amination. In Comprehensive Organometallic Chemistry III. Y. Takemoto, H. Miyabe; Eds. Crabtree, R. H.; Mingos, D. M. P.; Elsevier: Oxford, Vol. 10.15, 695-724. (2006).

Reaction of Nitro Organic Compounds Using Thiourea Catalysts Anchored to Polymer Support. H. Miyabe, S. Tuchida, M. Yamauchi, Y. Takemoto, Synthesis, (19), 3295-3300 (2006).

Enantioselective Cascade Radical Addition-Cyclization-Trapping Reactions. H. Miyabe, R. Asada, A. Toyoda, Y. Takemoto, Angew. Chem. Int. Ed., 45 (35), 5863-5866 (2006).

Thiourea-Catalyzed Asymmetric Michael Addition of Activated Methylene Compounds to????-Unsaturated Imides: Dual Activation of Imide by Intra- and Intermolecular Hydrogen-bonding. T. Inokuma, Y. Hoashi, Y. Takemoto, J. Am. Chem. Soc., 128 (29), 9413-9419 (2006).

Palladium-Catalyzed Intramolecular Cyanoamidation of Alkynyl and Alkenyl Cyanoformamides. Y. Kobayashi, H. Kamisaki, R. Yanada, Y. Takemoto, Org. Lett., 8 (13), 2711-2713 (2006).

Efficient Synthesis of Indoles Using [3,3]-Sigmatropic Rearrangement of N-Trifluoroacetyl Enehydrazines. O. Miyata, N. Takeda, Y. Kimura, Y. Takemoto, N. Tohnai, M. Miyata, T. Naito, Tetrahedron, 62 (15), 3629-3647 (2006).

In(OTf)3-catalyzed Tandem Nucleophilic Addition and Cyclization of ortho-Alkynylarylaldimines to 1,2-Dihydroisoquinolines. R. Yanada, S. Obika, H. Kono, Y. Takemoto, Angew. Chem. Int. Ed., 45 (23), 3822-3825 (2006).

Reactive Ketimino Radical Acceptors: Intermolecular Alkyl Radical Addition to Imines with a Phenolic Hydroxyl Group. H. Miyabe, Y. Yamaoka, Y. Takemoto, J. Org. Chem., 71 (5), 2099-2106 (2006).

Organocatalytic Enantioselective Hydrazination of 1,3-Dicarbonyl Compounds: Asymmetric Synthesis of α,α-Disubstituted α-Amino Acids. X. Xu, T. Yabuta, P. Yuan, Y. Takemoto, Synlett, (1), 137-140 (2006).
Bifunctional Thiourea-Catalyzed Diastereo- and Enantioselective Aza-Henry Reaction. X. Xu, T. Furukawa, T. Okino, H. Miyabe, Y. Takemoto, Chem. Eur. J., 12, 466-476 (2006).

Enantioselective Tandem Michael Reaction to Nitroalkene Catalyzed by Bifunctional Thiourea: Total Synthesis of (-)-Epibatidine. Y. Hoashi, T. Yabuta, P. Yuan, H. Miyabe, Y. Takemoto, Tetrahedron, 62 (2-3), 365-374 (2006).

生物活性物質の迅速合成を指向した金属反応剤によるラクタム形成反応の開発 安井義純, 竹本佳司, 化学工業, 57 (19), 729-733 (2006).

チオ尿素系不斉有機分子触媒の創製「有機分子触媒の新展開」 竹本佳司, 監修 柴崎正勝, シーエムシー出版, Tokyo, 167-179 (2006).


2005

Enantio- and Diastereoselective Michael Reaction of 1,3-Dicarbonyl Compounds to Nitroolefins Catalyzed by a Bifunctional Thiourea. T. Okino, Y. Hoashi, T. Furukawa, X. Xuenong, Y. Takemoto, J. Am. Chem. Soc., 127 (1), 119-125 (2005).

Enantioselective Michael Addition to α,β-Unsaturated Imides Catalyzed by a Bifunctional Organocatalyst. Y. Hoashi, T. Okino, Y. Takemoto, Angew. Chem. Int. Ed., 44 (26), 4032-4035 (2005).

Recognition and Activation by Ureas and Thioureas: Stereoselective Reactions Using Ureas and Thioureas as Hydrogen-Bonding Donors. Y. Takemoto, Org. Biomol. Chem., 3 (24), 4299 - 4306 (2005).

Regio- and Stereocontrolled Palladium or Iridium-Catalyzed Allylation. H. Miyabe, Y. Takemoto, Synlett, (11), 1641-1655 (2005).

A Convenient Synthesis of (E)-α-alkylidene-γ-lactams and (E)-3-alkylideneoxindoles by Rhodium-Catalyzed Intramolecular Hydroamidation, Y. Kobayashi, H. Kamisaki, K. Yanada, R. Yanada, Y. Takemoto, Tetrahedron Lett., 46, 7549-7532 (2005).

Stereoselective Synthesis of 3-Alkylideneoxindoles Using Tandem In-Mediated Carbometallation and Pd-Catalyzed Cross-Coupling Reaction. R. Yanada, S. Obika, Y. Kobayashi, T. Inokuma, M. Oyama, Y. Takemoto, Adv. Synth. Cat., 347, 1632-1642 (2005).

Stereoselective Synthesis of 3-Alkylideneoxindoles via Palladium-Catalyzed Domino Reactions, R. Yanada, S. Obika, T. Inokuma, K. Yanada, M. Yamashita, S. Ohta, Y. Takemoto, J. Org. Chem. 70 (17), 6972-6975 (2005).

New utilization of optically active homoallylamines: Highly stereoselective synthesis of cyclic guanidine and thiourea, R. Yanada, A. Kaieda, K. Yanada, Y. Takemoto, Heterocycles, 66, 101-106 (2005).

Selective Synthesis of Allylated Oxime Ethers and Nitrones Based on Palladium-Catalyzed Allylic Substitution of Oximes. H. Miyabe, K. Yoshida, V. K. Reddy, A. Matsumura, Y. Takemoto, J. Org. Chem., 70 (14), 5630-5635 (2005).

Triethylborane-Induced Intermolecular Radical Addition to Ketimines. H. Miyabe, Y. Yamaoka, Y. Takemoto, J. Org. Chem., 70 (8), 3324-3327 (2005).

Hydroxylamines as Oxygen Atom Nucleophiles in Transition-Metal-Catalyzed Allylic Substitution. H. Miyabe, K. Yoshida, M. Yamauchi, Y. Takemoto, J. Org. Chem., 70 (6), 2148-2153 (2005).

Asymmetric Synthetic Study of Macrolactin Analogues. Y. Kobayashi, A. Fukuda, T. Kimachi, M. Ju-ichi, Y. Takemoto, Tetrahedron, 61 (10), 2607-2622 (2005).

Synthesis of α,α-Disubstituted Amino Acids Based on Tandem Reaction of Dehydroamino Acid Derivatives. H. Miyabe, R. Asada & Y. Takemoto, Tetrahedron, 61 (1), 385-393 (2005).


2004

Antiproliferative Activity of Rhinocanthus nasutus (L.) Kurz Extracts and the Active Moiety, Rhinacanthin C. A. Gotoh, T. Sakaeda, T. Kimura, T. Shirakawa, Y. Wada, A. Wada, T. Kimachi, Y. Takemoto, A. Iida, S. Iwakawa, M. Hirai, H. Tomita, N. Okamura, T. Nakamura, K. Okumura, Biol. Pharm. Bull., 27 (7), 1070-1074 (2004).

Bifunctional Thiourea-Catalyzed Enantioselective Double Michael Reaction of γ,δ-Unsaturated -Ketoester to Nitroalkene: Asymmetric Synthesis of (-)-Epibatidine. Y. Hoashi, T. Yabuta, Y. Takemoto, Tetrahedron Lett., 45 (50), 9185-9188 (2004).

Asymmetric Synthesis of Macrolactin A Analogue. Y. Kobayashi, A. Fukuda, T. Kimachi, M. Ju-ichi, Y. Takemoto, Tetrahedron. Lett., 45 (4), 677-680 (2004).

Free Radical-Mediated Tandem Reaction of Dehydroamino Acid Derivative with π-Allyl Palladium Complex: Synthesis of α,α-Disubstituted Amino Acids. H. Miyabe, R. Asada, K. Yoshida, Y. Takemoto, Synlett, (3), 540-542 (2004).

Utility of the Iridium Complex of the Pybox Ligand in Regio- and Enantioselective Allylic Substitution. H. Miyabe, A. Matsumura, K. Moriyama, Y. Takemoto, Org. Lett., 6 (24), 4631-4634 (2004).

Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines Having Electron-Withdrawing Substituents. H. Miyabe, A. Matsumura, K. Yoshida, M. Yamauchi, Y. Takemoto, Letters in Organic Chemistry, 1 (2), 119-121 (2004).

Novel Synthesis of O-Allylated Oxime Ethers Based on Allylic Substitution with Oximes. H. Miyabe, A. Matsumura, K. Yoshida, M. Yamauchi, Y. Takemoto, Synlett, (12), 2123-2126 (2004).

Aqueous Medium Radical Addition to Ketimines with a Phenolic Hydroxyl Group. H. Miyabe, Y. Yamaoka, Y. Takemoto. Synlett, (14), 2597-2599 (2004).

Palladium-Indium Iodide-Mediated Allylation and Propargylation of Glyoxylic Oxime Ether and Hydrazone: The Role of Water in Directing the Diastereoselective Allylation. H. Miyabe, Y. Yamaoka, T. Naito, Y. Takemoto, J. Org. Chem., 69 (4), 1415-1418 (2004).

Stereodivergent Synthesis of Chiral 2-Alkenylaziridines: Palladium(0)-Catalyzed 2,3-cis-Selective Aziridination and Base-Mediated 2,3-trans-Selective Aziridination. H. Ohno, Y. Takemoto, N. Fujii, T. Tanaka, T. Ibuka, Chem. Pharm. Bull., 52 (1), 111-119 (2004).

Enantioselective Aza-Henry Reaction Catalyzed by Bifunctional Organocatalyst. T. Okino, S. Nakamura, T. Furukawa, Y. Takemoto, Org. Lett., 6 (4), 625-627 (2004).

Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes: Synthesis and Biological Evaluation. R. Yanada, N. Nishimori, A. Matsumura, S. Obika, H. Mitsuya, N. Fujii, Y. Takemoto, J. Org. Chem., 67 (7), 2417-2422 (2004).

Indium-Mediated Radical Cyclization of Iodoalkenes and Iodoalkynes with and without Allylic and Propargylic Leaving Groups. R. Yanada, S. Obika, N. Nishimori, M. Yamauchi, Y. Takemoto, Tetrahedron Lett., 45 (11), 2331-2334 (2004).

Stereoselective Synthesis of 3-Alkylideneoxindoles Using Tandem In-Mediated Carbometallation and Pd-Catalyzed Coupling Reaction. R. Yanada, S. Obika, M. Oyama, Y. Takemoto, Org. Lett., 6 (16), 2825-2828 (2004).

分子不斉を構築する機能性分子 竹本佳司 ファルマシア, 40 (6), 499-501 (2004).


2003

Enantioselective Michael Reaction of Malonates to Nitroolefins Catalyzed by Bifunctional Organocatalysts. T. Okino, Y. Hoashi, Y. Takemoto, J. Am. Chem. Soc., 125 (42), 12672-12673 (2003).

Enantio- and Diastereoselective Ir-Catalyzed Allylic Substitutions for Asymmetric Synthesis of Amino Acid Derivatives. T. Kanayama, K. Yoshida, H. Miyabe, Y. Takemoto, Angew. Chem. Int. Ed., 42 (18), 2054-2056 (2003).

Synthetic Studies on Macrolactin A by Using a (Diene)Fe(CO)3 Complex. A. Fukuda, Y. Kobayashi, T. Kimachi, Y. Takemoto, Tetrahedron, 59 (47), 9305-9313 (2003).

Synthesis of β-Substituted α-Amino Acids Using Iridium-Catalyzed Asymmetric Allylic Substitution. T. Kanayama, K. Yoshida, H. Miyabe, T. Kimachi, Y. Takemoto, J. Org. Chem., 68 (16), 6197-6201 (2003).

Regioselectivity in Palladium-Indium Iodide-Mediated Allylation Reaction of Glyoxylic Oxime Ether and N-Sulfonylimine. H. Miyabe, Y. Yamaoka, T. Naito, Y. Takemoto, J. Org. Chem., 68 (17), 6745-6751 (2003).

Synthesis of azacycles based on Iridium-catalyzed sequential allylic amination. H. Miyabe, K. Yoshida, Y. Kobayashi, A. Matsumura, Y. Takemoto, Synlett, (7), 1031-1033 (2003).

O-Allylic Substitution of Hydroxylamine Derivatives Having an N-Electron-Withdrawing Substituent. H. Miyabe, K. Yoshida, A. Matsumura, M. Yamauchi, Y. Takemoto, Synlett, (4), 567-569 (2003).

Thiourea-Catalyzed Nucleophilic Addition of TMSCN and Ketene Silyl Acetals to Nitrones and Aldehydes. T. Okino, Y. Hoashi, Y. Takemoto, Tetrahedron Lett., 44 (14), 2817-2821 (2003).

Indium-Mediated Tandem Radical Addition-Cyclization-Trap Reactions in Aqueous Media. M. Ueda, H. Miyabe, A. Nishimura, O. Miyata, Y. Takemoto, T. Naito, Org. Lett., 5 (21), 3835-3838 (2003).

イミン類への炭素ラジカル付加反応の開発 宮部豪人 薬学雑誌, 123 (5), 285-294 (2003).


2002

Asymmetric Synthesis of β2,3-Amino Acids by InI-Pd(0)-Promoted Metalation and Addition of Chiral 2-Vinylaziridines. M. Anzai, R. Yanada, N. Fujii, H. Ohno, T. Ibuka, Y. Takemoto, Tetrahedron, 58 (26), 5231-5239 (2002).

Synthetic Study on CP-263,114 (Phomoidride B) by SET-Mediated Fragmentation. T. Matsushita, H. Ashida, T. Kimachi, Y. Takemoto, Chem. Commun., (8), 814-815 (2002).

Pd-Catalyzed Asymmetric Allylic Alkylation of Glycine Iminoester Using a Chiral Phase-Transfer Catalyst. M. Nakoji, T. Kanayama, T. Okino, Y. Takemoto, J. Org. Chem., 67 (21), 7418-7423 (2002).

Synthesis of Allenes from Allylic Alcohol Derivatives Bearing a Bromine Atom Using a Palladium(0)/Diethylzinc System. H. Ohno, K. Miyamura, T. Tanaka, S. Oishi, A. Toda, Y. Takemoto, N. Fujii, T. Ibuka, J. Org. Chem., 67 (4), 1359-1367 (2002).

Indium-Mediated Atom-Transfer Cyclizations and Reductive Cyclizations. R. Yanada, N. Nishimori, A. Matsumura, N. Fujii, Y. Takemoto, Tetrahedron Lett., 43 (26), 4585-4588 (2002).

OsO4-Catalyzed Dihydroxylation of Olefins in Ionic Liquid [emim]BF4: A Recoverable and Reusable Osmium. R. Yanada, Y. Takemoto, Tetrahedron Lett., 43 (38), 6849-6852 (2002).

キレーション効果を利用したC−HおよびC−C結合の触媒的活性化 宮部 豪人 化学, 57 (9), 66-67 (2002).


2001

Asymmetric Total Synthesis of Halicholactone. Y. Baba, G. Saha, S. Nakao, C. Iwata, T. Tanaka, T. Ibuka, H. Ohishi, Y. Takemoto, J. Org. Chem., 66 (1), 81-88 (2001).

Novel Sparteine-Mediated Enantio-Dichotomic Formal Synthesis of (R)-(-)- and (S)-(+)-Curcuphenol. T. Kimachi, Y. Takemoto, J. Org. Chem., 66 (8), 2700-2704 (2001).

Chiral Phosphine-Free Pd-Mediated Asymmetric Allylation of Prochiral Enolate with a Chiral Phase-Transfer Catalyst. M. Nakoji, T. Kanayama, T. Okino, Y. Takemoto, Org. Lett., 3 (21), 3329-3331 (2001).

Stereoselective Synthesis of 2-Alkenylaziridines and 2-Alkenylazetidines by Palladium-Catalyzed Intramolecular Amination of α- and β-Amino Allenes. H. Ohno, M. Anzai, A. Toda, S. Ohishi, N. Fujii, T. Tanaka, Y. Takemoto, T. Ibuka, J. Org. Chem., 66 (14), 4904-4914 (2001).

Role of the Planar Chirality of Chiral Amino Alcohols Bearing Iron Tricarbonyl in Asymmetric Alkylation of Diethylzinc to Aldehydes. K. Okamoto, T. Kimachi, T. Ibuka, Y. Takemoto, Tetrahedron: Asymmtry, 12 (3), 463-467 (2001).

Asymmetric Alkylation of tert-Butyl Glycinate Schiff Base with Chiral Quaternary Ammonium Salt under Micellar Conditions. T. Okino, Y. Takemoto, Org. Lett., 3 (10), 1515-1517 (2001).

Stereoselective Synthesis of Nonracemic 1,3-Amino Alcohols from Chiral 2-Vinylaziridines by InI-Pd(0)-Promoted Metalation. Y. Takemoto, M. Anzai, R. Yanada, N. Fujii, H. Ohno, T. Ibuka, Tetrahedron Lett., 42 (9), 1725-1728 (2001).

Stereospecific 1,3-Migration of an Fe(CO)3 Group on Acyclic Conjugated Polyenes: Application to Remote and Iterative Asymmetric Induction. Y. Takemoto, K. Ishii, T. Ibuka, Y. Miwa, T. Taga, S. Nakao, T. Tanaka, H. Ohishi, Y. Kai, N. Kanehisa, J. Org. Chem., 66, 6116-6123 (2001).

Diastereoselective Barbier-Type and Palladium-Mediated Allylaion of Optically Active Aldimine with Allylindium Reagents. R. Yanada, A. Kaieda, Y. Takemoto, J. Org. Chem., 66 (22), 7516-7518 (2001).

Aluminum-Controlled Reactivity and Diastereoselectivity Toward Radical Reactions of Optically Active Aldimines with Metallic Samarium. R. Yanada, M. Okaniwa, A. Kaieda, T. Ibuka, Y. Takemoto, J. Org. Chem., 66 (4), 1283-1286 (2001).


2000

Stereoselective Synthesis of Chiral Amino Allenes by Organocopper-Mediated anti SN2'-Substitution Reaction of Chiral Ethynylaziridines. H. Ohno, A. Toda, N. Fujii, Y. Takemoto, T. Tanaka, T. Ibuka, Tetrahedron, 56 (18), 2811-2820 (2000).

Novel Synthesis of Chiral Terminal Allenes via Palladium(0)-Catalyzed Reduction of Mesylates of 2-Bromoalk-2-en-1-ols Bearing a Protected Amino Group, Using Diethylzinc. H. Ohno, A. Toda, S. Oishi, T. Tanaka, Y. Takemoto, N. Fujii, T. Ibuka, Tetrahedron Lett., 41 (26), 5131-5134 (2000).

Asymmetric Total Synthesis of Halicholactone. Y. Takemoto, Y. Baba, G. Saha, S. Nakao, C. Iwata, T. Tanaka, T. Ibuka, Tetrahedron Lett., 41 (19), 3653-3656 (2000).

Remote Asymmetric Induction by Using 1,3-Migration Reaction of (Diene)iron Tricarbonyl Complexes. Y. Takemoto, K. Ishii, A. Honda, K. Okamoto, R. Yanada, T. Ibuka, Chem. Commun., 1445-1446 (2000).

Enantioselective Addition of Diethylzinc to Aldehydes with Novel Chiral C2-Symmetric Dimeric Ligands. M. Okaniwa, R. Yanada, T. Ibuka. Tetrahedron Lett. 41 (7), 1047-1050 (2000).

Stereospecific 1,3-Migration of an Fe(CO)3 Group on Acyclic Conjugated Trienes Bearing an Electron-Withdrawing Group. Y. Takemoto, K. Ishii, Y. Miwa, T. Taga, T. Ibuka, S. Nakao, T. Tanaka, Tetrahedron Lett., 41 (1), 85-88 (2000).

オキシムエーテルをラジカル受容体とした固相ラジカル反応の開発 宮部 豪人 薬学雑誌, 120 (8), 667-676 (2000).

アルデヒドやケトンをラジカル受容体とするには 宮部 豪人 ファルマシア, 36, 407-408 (2000).

金属サマリウムを利用する合成反応の開発 柳田玲子, 井深俊郎 有機合成化学協会誌, 58 (6), 597-605 (2000).


1999

Utility of A Diene-tricarbonyliron Complex as A Mobile Chiral Auxiliary: Regio- and Stereocontrolled Functionalization of Acyclic Diene Ligands. Y. Takemoto, N. Yoshikawa, Y. Baba, C. Iwata, T. Tanaka, T. Ibuka, H. Ohishi, J. Am. Chem. Soc., 121 (39), 9143-9154 (1999).

Synthesis of Chiral Amino Allenes via an Organocyanocuprate-Mediated Ring-Opening Reaction of Enantiopure Ethynylaziridines. H. Ohno, A. Toda, Y. Miwa, T. Taga, N. Fujii, T. Ibuka, Tetrahedron Lett., 40 (2), 349-352 (1999).

Stimulation of Nerve Growth Factor Synthesis/Secretion by 5-Deazaflavoquinone in Mouse Astrocytes. Tanigawa, H. Ohde, F. Yoneda, T. Kimachi, M. Toyomoto, S. Inoue, K. Ikeda, K. Hayashi, J. Biochem. Mol. Bio. & Biophys., 3, 231-237 (1999).

Sterically Congested Chiral Activated Aziridines: Synthesis of Both 2,3-Cis- and 2,3-Trans-2-Alkenyl-3-alkylaziridines from Common Intermediates. H. Ohno, A. Toda, N. Fujii, Y. Miwa, T. Taga, Y. Yamaoka, E. Osawa, T. Ibuka, Tetrahedron Lett., 40 (7), 1331-1334 (1999).

First Palladium-Catalyzed Aziridination Reaction of Amino Allenes. H. Ohno, A. Toda, Y. Miwa, T. Taga, N. Fujii, T. Ibuka, J. Org. Chem., 64 (9), 2992-2993 (1999).

Regiospecific Ring-Opening Reactions of β-Aziridinyl α,β-Enoates with Acids: Application to the Stereoselective Synthesis of a Couple of Diastereoisomeric (E)-Alkene Dipeptide Isosteres from a Single β-Aziridinyl α,β-Enoate and to the Convenient Preparation of Amino Alcohols Bearing α,β-Unsaturated Ester Groups. H. Tamamura, M. Yamashita, Y. Nakajima, K. Sakano, A. Otaka, H. Ohno, T. Ibuka, N. Fujii, J. Chem. Soc., Perkin Trans. 1, (20), 2983-2996 (1999).

Palladium-Catalyzed Regio- and Stereoselective Synthesis of N-Protected 2,4-Dialkylated Azacyclobutanes from Amino Allenes. M. Anzai, A. Toda, H. Ohno, Y. Takemoto, N. Fujii, T. Ibuka, Tetrahedron Lett., 40 (41), 7393-7397 (1999).

Selective Synthesis of Nonracemic 3-Pyrrolines and 2,3-Cis-2-vinylaziridines from (Z)-Amino Allylic Alcohols: A New Synthetic Route to Chiral 3,4-Dehydroproline. K. Ishii, H. Ohno, Y. Takemoto, T. Ibuka, Synlett, (2), 228-230 (1999).

Selective Synthesis of Cis-2-vinyl-3-alkylaziridines and 3-Pyrrolines from Common Intermediates (Z)-4-N-Arylsulfonylaminoalk-2-en-1-ols. K. Ishii, H. Ohno, Y. Takemoto, E. Osawa, Y. Yamaoka, N. Fujii, T. Ibuka, J. Chem. Soc., Perkin Trans.1, (15), 2155-2163 (1999).

Convenient Syntheses of Chiral 3-Substituted 2-Ethynylaziridines. H. Ohno, A. Toda, Y. Takemoto, N. Fujii, T. Ibuka, J. Chem. Soc., Perkin Trans. 1, (20), 2949-2962 (1999).

CAN Induced Double Ether Ring Formation: Synthesis of Trans- and Cis-fused Tricyclic Ethers from 3-Oxabicyclo[3.1.0]hexyl Sulfides. Y. Takemoto, S.-i. Furuse, H. Hayase, T. Echigo, C. Iwata, T. Tanaka, T. Ibuka, Chem. Commun., (24), 2515-2516 (1999).

Diastereoselective Allylation and Alkylation of Optically Active Imines with Metallic Samarium and A Catalytic Amount of Iodine. R. Yanada, N. Negoro, M. Okaniwa, T. Ibuka, Tetrahedron, 55 (49), 13947-13956 (1999).

Samarium-Promoted Diastereoselective Reductive Coupling of Optically Active Imines. R. Yanada, N. Negoro, M. Okaniwa, Y. Miwa, T. Taga, K. Yanada, T. Fujita, Synlett, (5), 537-540 (1999).

Sparteine-Mediated Enantioselective [2,3]-Wittig Rearrangement of Allyl ortho-Substituted Benzyl Ethers and ortho-Substituted Benzyl Prenyl Ethers. T. Kawasaki, T. Kimachi, Tetrahedron, 55 (22), 6847-6862 (1999).


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