・N-Heterocyclic carbene-catalyzed direct cross-aza-benzoin reaction: Efficient synthesis of α-amino-β-keto esters, Takuya Uno, Yusuke Kobayashi, Yoshiji Takemoto, Beilstein J. Org. Chem. 2012, 8, 1499-1504 DOI:10.3762/bjoc.8.169

・Palladium-Catalyzed Cascade Process Consisting of Isocyanide Insertion and Benzylic C(sp3)-H Activation: Concise Synthesis of Indole Derivatives, Takeshi Nanjo, Chihiro Tsukano, and Yoshiji Takemoto, Org. Lett. 2012, 14, ASAP DOI: 10.1021/ol302035j

・Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition?cyclization?trapping reactions, H. Miyabe, R. Asada, Y. Takemoto, Org. Biomol. Chem., 2012, 10, 3519-3530. DOI:10.1039/C2OB25073J

・Facile isomerization of silyl enol ethers catalyzed by triflic imide and its application to one-pot isomerization-(2 + 2) cycloaddition, K. Inanaga, Y. Ogawa, Y. Nagamoto, A. Daigaku, H. Tokuyama, Y. Takemoto, K. Takasu, Beilstein J. Org. Chem., 2012, 8, 658-661. DOI:10.1039/C2OB25111F

・Acid-Catalyzed [2 + 2] Cycloaddition at Room-Temperature with Suppression of Side Reactions by Using a Flow Microreactor System. Kei Kurahashi, Yoshiji Takemoto, and Kiyosei Takasu, ChemSusChem 2012, 5 (2), 270-273. DOI: 10.1002/cssc.201100373

・Organocatalyzed Isomerization of a-Substituted Alkynoates into Trisubstituted Allenoates by Dynamic Kinetic Resolution, Tsubasa Inokuma, Masaya Furukawa, Yusuke Suzuki, Tetsutaro Kimachi, Yusuke Kobayashi, Yoshiji Takemoto, ChemCatChem 2012, 4, 983-985. DOI: 10.1002/cctc.201200065

・Platinum Catalyzed 7-endo Cyclization of Internal Alkynyl Amides and its Application to Synthesis of the Caprazamycin Core, C. Tsukano, S. Yokouchi, A. L. Girard, T. Kuribayashi, S. Sakamoto, T. Enomoto, Y. Takemoto Org. Biomol. Chem., 2012,10, 6074-6086 DOI:10.1039/C2OB25111F

・Synthesis of Highly Oxidized Quinolizidine via Reduction of Acylpyridinium Cations, and Total Syntheses of Quinolizidines 207I and 1-epi-207I, C. Tsukano, A. Oimura, I. Enkhtaivan, Y. Takemoto, Org. Lett. 2012, 14, ASAP. DOI:10.1021/ol300541u

・Palladium-Catalyzed Amidation by Chemoselective C(sp3)H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor. C. Tsukano, M. Okuno, Y. Takemoto, Angew. Chem. Int. Ed., 2012, 51, 2763-2766. DOI:10.1002/anie.201108889

・NHC-catalyzed thioesterification of aldehydes by external redox activation. T. Uno, T. Inokuma, Y. Takemoto, Chem. Commun. 2012, 48, 1901-1903. DOI:10.1039/C2CC17183J

・Synthesis of 2-Iminoinolines via Samarium Diiodide Mediated Reductive Cyclization of Carbodiimides T. Ishida, C. Tsukano, Y. Takemoto, Chem. Lett., 2012, 41(1), 44-46. DOI:10.1246/cl.2012.44

2011

・Organocatalytic Asymmetric Neber Reaction for the Synthesis of 2H-Azirine Carboxylic Esters. S. Sakamoto, T. Inokuma, and Y. Takemoto, Org. Lett., 2011, 13(24), 6374-6377. DOI:10.1021/ol2026747

・Synthesis of Optically Active N-Aryl Amino Acid Derivatives through the Asymmetric Petasis Reaction Catalyzed by a Novel Hydroxy-Thiourea Catalyst. T. Inokuma, Y. Suzuki, T. Sakaeda, and Y. Takemoto, Chem. Asian J. 2011, 6, 2902-2906. DOI:10.1002/asia.201100453

・Bifunctional Hydrogen-Bond Donors That Bear a Quinazoline or Benzothiadiazine Skeleton for Asymmetric Organocatalysis. T. Inokuma, M. Furukawa, T. Uno, Y. Suzuki, K. Yoshida, Y. Yano, K. Matsuzaki Y. Takemoto, Chem. Eur. J., 2011, 17,(37), 10470-10477. DOI:10.1002/chem.201101338

・Formal (3+3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition-Claisen Condensation Accompanied with Isomerization of Silyl Enol Ethers. A. Takumi, T. Yoshiji, T, Kiyosei CHEMICAL & PHARMACEUTICAL BULLETIN 2011, 59 (9), 1190-1193 DOI:10.1248/cpb.59.1190

・Regio- and Enantioselective Allylic Substitution with Less Active N- or O-Nucleophiles Catalyzed by Iridium-Complex of Bis(oxazolinyl)pyridine M. Hideto, M. Katsuhiko, T. Yoshiji CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (9), 714-720 DOI:10.1248/cpb.59.714

・Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines N. Shindoh, K. Kitaura, Y. Takemoto, K. Takasu, J. Am. Chem. Soc., 2011, 133, 8470-8473 DOI:10.1021/ja202576e

・UNPRECEDENTED SYNTHESIS OF N,N-DIVINYLAMINES BY Tf(2)NH-CATALYZED REACTION OF YNAMIDE WITH KETIMINE N. Shindoh, Y. Takemoto, K. Takasu, Heterocycles, 2011, 82(2), 1133 DOI:10.3987/COM-10-S(E)87

・Control of 6-Exo and 7-Endo Cyclizations of Alkynylamides using Platinum and Bismuth Catalysts Anne-Lise Girard, Taro Enomoto, Shinsuke Yokouchi, Chihiro Tsukano and Yoshiji Takemoto, Chemistry - An Asian Journal, 2011, 6, 1321-1324 DOI:10.1002/asia.201100209

・Domino Pd-Catalyzed Heck-Type Cyclization and Bi-Catalyzed Hydroamination: Formal Syntheses of Elacomine and Isoelacomine. H. Kamisaki, T. Nanjo, C.Tsukano, Y. Takemoto, Chem. Eur. J., 2011, 17,(2), 626-633. DOI:10.1002/chem.201002287

・Flexible Strategy for Syntheses of Spirooxindoles using Palladium-catalyzed Carbosilylation and Sakurai-type Cyclization Sudhir M. Hande, Motoyuki Nakajima, Haruhi Kamisaki, Chihiro Tsukano, and Yoshiji Takemoto, Organic Letters 2011, 13(7), 1828-1831. DOI:10.1021/ol2003447

・Synthetic studies of salinosporamide A through intramolecular hydroamidation of alkynes. H. Kamisaki, Y. Kobayashi, T. Kimachi, Y. Yasui, Y. Takemoto, J. Organomet. Chem. 2011, 696 (1), 42-45. DOI:10.1016/j.jorganchem.2010.06.021

2010

・Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole. K. Takasu, T. Azuma, I. Enkhtaivan, Y. Takemoto, Molecules, 2010, 15, 8327-8348.DOI:10.3390/molecules15118327

・Catalytic Asymmetric Synthesis of Both Enantiomers of 4 Substituted 1,4-Dihydropyridines with the Use of Bifunctional Thiourea-Ammonium Salts Bearing Different Counterions. K. Yoshida, T. Inokuma, K. Takasu, Y. Takemoto, Molecules, 2010, 15, 8305-8326.DOI:10.3390/molecules15118305

・Auto-tandem Catalysis: Facile Synthesis of Substituted Alkylidenecyclo-hexanones by Domino (4 + 2) Cycloaddition-Elimination Raction. K. Takasu, T. Tanaka, T. Azuma, Y. Takemoto, Chem. Commun., 2010, 46, 8246-8248. DOI:10.1039/C0CC03336G

・Stereocontrolled Synthesis of Spiro[n.2]alkenes by Ring Contraction of Fused-Cyclobutanols. K. Takasu, Y. Nagamoto, Y. Takemoto, Chem. Eur. J., 16(28), 8427-8432, (2010). DOI:10.1002/chem.201000930

・Synthetic Study toward Ecteinascidin 743: Concise Construction of the Diazabicyclo[3.3.1]nonane Skeleton and Assembly of the Pentacyclic Core. T. Enomoto, Y. Yasui, Y. Takemoto, J. Org. Chem., 75(14), 4876-4879. DOI:10.1021/jo100788j

・Synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed intramolecular cyanoamidation. Y. Yasui, H. Kamisaki, T. Ishida, Y. Takemoto, Tetrahedron, 66(10), 1980-1989 (2010). DOI:10.1016/j.tet.2010.01.073

・Br?nsted Acid―Thiourea Co-catalysis: Asymmetric Synthesis of Functionalized 1,4-Dihydropyridines from α-Enaminoesters and α,β-Unsaturated Aldehydes. K. Yoshida, T. Inokuma, K. Takasu, Y. Takemoto, Synlett, (12), 1865-1869 (2010). DOI:10.1055/s-0030-1258090

・Concise Total Synthesis of (±)-Lycodine. C. Tsukano, L. Zhao, Y. Takemoto, M. Hirama, Eur. J. Org. Chem., (22), 4198-4200, (2010) DOI:10.1002/ejoc.201000667 .

・Synthesis of trifunctional thioureas bearing 1,5-disubstituted triazole tether by Ru-catalyzed Huisgen cycloaddition. K. Takasu, T. Azuma, Y. Takemoto, Tetrahedron Lett. 51(20), 2737-2740 (2010). DOI:10.1016/j.tetlet.2010.03.053

・Unprecedented Synthesis of N,N-Divinylamines by Tf2NH-Catalyzed Reaction of Ynamide with Ketimine. N. Shindoh, Y. Takemoto, K. Takasu, Heterocycles in press.

・Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma. A. Kuwahara, M. Yamamori, K. Nishiguchi, T. Okuno, N. Chayahara, I. Miki, T. Tamura, K. Kadoyama, T. Inokuma, Y. Takemoto, T. Nakamura, K. Kataoka, T. Sakaeda, Int. J. Med. Sci., 7(1), 48-54(2010). DOI

・Development of Chiral Thiourea Catalysts and Its Application to Asymmetric Catalytic Reactions. Y. Takemoto, Chem. Pharm. Bull., 58(5), 593-601(2010). DOI

・有機ホウ素試薬を利用した不斉チオ尿素触媒反応の開発、竹本佳司、ファインケミカル、2010, 39(8), 22-32.

2009

・Hydroxyl Group-Directed Organocatalytic Asymmetric Michael Addition of α,β-Unsaturated Ketones with Alkenylboronic Acids. T. Inokuma, K. Takasu, T. Sakaeda, Y. Takemoto, Org. Lett., 11(11), 2425-2428 (2009). DOI:10.1021/ol9006053

・Atropisomerism of .alpha.,.beta.-Unsaturated Amidines: Stereoselective Synthesis by Catalytic Cascade Reaction and Optical Resolution. N. Shindoh, Y. Takemoto, K. Takasu, Chem. Eur. J., 15(29), 7026-7030 (2009). DOI:10.1002/chem.200901103

・Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton. Y. Yasui, T. Kinugawa, Y. Takemoto, Chem. Commun., (28), 4275-4277 (2009). DOI:10.1039/B907210A

・Gold(I)-Catalyzed Tandem Reactions Initiated by Hydroamination of Alkynyl Carbamates: Application to the Synthesis of Nitidine. T. Enomoto, A.-L. Girard, Y. Yasui, Y. Takemoto, J. Org. Chem., 74(23), 9158-9164 (2009). DOI:10.1021/jo901906b

・Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines: Convenient and Direct Modification of Guanidines. H. Miyabe, K. Yoshida, V. K. Reddy, Y. Takemoto, J. Org. Chem., 74(1), 305-311 (2009). DOI:10.1021/jo802271d

・Pd-catalyzed intramolecular amidation of 2-(buta-1,3-dienyl)phenylcarbamoyl chloride: a concise synthesis of spiro[indoline-3,3'-pyrrolidine]. H. Kamisaki, Y. Yasui, Y. Takemoto, Tetrahedron Lett., 50(21), 2589-2592 (2009). DOI:10.1016/j.tetlet.2009.03.100

・Synthesis of chiral oxime ethers based on regio- and enantioselective allylic substitution catalyzed by iridium-pybox complex. H. Miyabe, A. Matsumura, K. Yoshida, Y. Takemoto, Tetrahedron, 65(23), 4464-4470 (2009). DOI:10.1016/j.tet.2009.04.005

・Enantioselective nitrocyclopropanation of .alpha.,.beta.-unsaturated .alpha.-cyanoimides catalyzed by bifunctional thiourea. T. Inokuma, S. Sakamoto, Y. Takemoto, Synlett, (10), 1627-1630 (2009). DOI:10.1055/s-0029-1217331

・Preparation of α,β-Unsaturated Lactams through Intramolecular Electrophilic Carbamoylation of Alkenes. Y. Yasui, I. Kakinokihara, H. Takeda, Y. Takemoto, Synthesis, (23), 3989-3993 (2009). DOI:10.1055/s-0029-1217028

・Synthesis of indolo[2,3-b]quinolines by palladium-catalyzed annulation of unsaturated isothioureas. H. Takeda, T. Ishida, Y. Takemoto, Chem. Lett., 38(8), 772-773 (2009). DOI:10.1246/cl.2009.772

・Asymmetric Synthesis of 4-Substituted 2,6-Dioxopiperidine-3-carbonitrile by Using Thiourea-Catalyzed Asymmetric Michael Addition. T. Inokuma, Y. Nagamoto, S. Sakamoto, H. Miyabe, K. Takasu, Y. Takemoto, Heterocycles, 79(1), 573-582 (2009). DOI:10.3987/COM-08-S(D)18

・Triflic Imide Catalyzed [3+2] Cycloaddition of Aldimines with α,α-Dimethylallylsilane. N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu, Heterocycles, 77(1), 187-192 (2009).DOI:10.3987/COM-08-S(F)17

・Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma. A. Kuwahara, M. Yamamori, K. Nishiguchi, T. Okuno, N. Chayahara, I. Miki, T. Tamura, T. Inokuma, Y. Takemoto, T. Nakamura, K. Kataoka, T. Sakaeda, Int. J. Med. Sci., 6(6), 305-311 (2009). DOI

・Auto-Tandem Catalysis: A Single Catalyst Activating Mechanistically Distinct Reactions in a Single Reactor. N. Shindoh, Y. Takemoto, K. Takasu, Chem. Eur. J., 15(45), 12168-12179 (2009). DOI:10.1002/chem.200901486

・Triflic Imide Catalyzed Cycloaddition Reactions. K. Takasu, Synlett, (12), 1905-1914 (2009). DOI:10.1055/s-0029-1217522

・インジウムを用いる合成反応の開発. 柳田玲子、竹本佳司, 有機合成化学協会誌, 67(3), 239-247 (2009).

2008

・Intra- and Intermolecular Amidation of C-C Unsaturated Bonds Through Palladium-Catalyzed Reactions of Carbamoyl Derivatives. Y. Yasui, Y. Takemoto, Chem. Rec. 8(6), 386-394 (2008).

・Toward General Access to the Aspidosperma-Type Terpenoid Indole Alkaloids: Synthesis of the Key 3,3-Disubstituted Piperidones through Enantioselective Intramolecular Heck-Type Reaction of Chloroformamides. Y. Yasui, H. Takeda, Y. Takemoto, Chem. Pharm. Bull. 56 (11), 1567-1574 (2008).

・Thiourea-Catalyzed Asymmetric Formal [3 + 2] Cycloaddition of Azomethine Ylides with Nitroolefins. J. Xie, K. Yoshida, K. Takasu, Y. Takemoto, Tetrahedron Lett. 49(48), 6910-6913 (2008).

・Discovery and Application of Asymmetric Reaction by Multi-Functional Thioureas. H. Miyabe, Y. Takemoto, Bull. Chem. Soc. Jpn. 81 (7), 785-795 (2008).

・Auto-Tandem Catalysis in the Synthesis of Substituted Quinolines from Aldimines and Electron-rich Olefins: Cascade Povarov-Hydrogen Transfer Reaction. N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu, J. Org. Chem. 73(19), 7451-7456 (2008).

・Enantioselective Synthesis of 3,3-Disubstituted Oxindoles through Pd-Catalyzed Cyanoamidation. Y. Yasui, H. Kamisaki, Y. Takemoto, Org. Lett. 10 (15), 3303-3306 (2008).

・Gold(I)-Catalyzed Hydroamination as a General Approach toward the Synthesis of Substituted Hydroisoquinolines: Remarkable Acceleration by Ethanol. T. Enomoto, S. Obika, Y. Yasui, Y. Takemoto, Synlett (11), 1647-1650 (2008).

・連続反応および多成分反応を基盤とする多置換シクロブタンの迅速合成法の開発、高須清誠、有機合成化学協会誌、66 (6), 554-563, 2008.

・Concise Synthesis of the CDE Ring System of Tetrahydroisoquinoline Alkaloids Using Carbophilic Lewis Acid-Catalyzed Hydroamidation and Oxidative Friedel-Crafts Cyclization. S. Obika, Y. Yasui, R. Yanada, Y. Takemoto, J. Org. Chem. 73 (13), 5206-5209 (2008).

・Indium(III)-Catalyzed Tandem Reaction with Alkynylbenzaldehydes and Alkynylanilines to Heteroaromatic Compounds. R. Yanada, K. Hashimoto, R. Tokizane, Y. Miwa, H. Minami, K. Yanada, M. Ishikura, Y. Takemoto, J. Org. Chem. 73 (13), 5135-5138 (2008).

・Enantioselective Synthesis of [1,2]-oxazinone scaffolds and [1,2]-oxazine core structures of FR900482. V. K. Reddy, H. Miyabe, M. Yamauchi, Y. Takemoto, Tetrahedron, 64 (6), 1040-1048 (2008).



2007

・Gold-Catalyzed Cyclization Reaction of Alkynyl tert-Butylcarbamates. H. Miyabe, Y. Sami, T. Naito, Y. Takemoto, Heterocyles, 73 (1), 187-190 (2007).

・Chiral Thiourea-catalyzed Direct Mannich Reactions. Y. Yamaoka, H. Miyabe, Y. Yasui, Y. Takemoto, Synthesis, 2007 (16), 2571-2575 (2007).

・Enantioselective Radical Cyclizations: A New Approach to Stereocontrol of Cascade Reactions. H. Miyabe, Y. Takemoto, Chem. Eur. J., 13 (26), 7280-7286 (2007).

・Enantioselective Cascade Radical Addition-Cyclization of Oxime Ethers. H. Miyabe, A. Toyoda, Y. Takemoto, Synlett, 2007 (12), 1885-1888 (2007).

・The Amino Thiourea-Catalyzed Asymmetric Nucleophilic Reactions. Y. Takemoto, H. Miyabe, Chimia, 61 (5), 269-275 (2007).

・One-Pot Amidation of Olefins through Pd-Catalyzed Coupling of Alkylboranes and Carbamoyl Chlorides. Y. Yasui, S. Tuschida, H. Miyabe, Y. Takemoto, J. Org. Chem., 72 (15), 5898-5900 (2007).

・Concise Synthesis of 1,2-Dihydroisoquinolines and 1H-Isochromones by Carbophilic Lewis Acid-Catalyzed Tandem Nucleophilic Addition and Cyclization of 2-(1-Alkynyl)arylaldimines and 2-(1-Alkynyl)aryaldehydes. S. Obika, H. Kono, Y. Yasui, R. Yanada, Y. Takemoto, J. Org. Chem., 72 (12), 4462-4468(2007).

・Catalytic Enantioselective Petasis-Type Reaction of Quinolines Catalyzed by a Newly Designed Thiourea Catalyst. Y. Yamaoka, H. Miyabe, Y. Takemoto, J. Am. Chem. Soc, 129 (21), 6686-6687 (2007).

・Intramolecular Cyanoamidation of Unsaturated Cyanoformamides Catalyzed by Palladium: An Efficient Synthesis of Multi-Functionalized Lactams. Y. Kobayashi, H. Kamisaki, H. Takeda, Y. Yasui, R. Yanada, Y. Takemoto, Tetrahedron, 63 (14), 2978-2989 (2007).


2006

・Development of Amino Thiourea Catalysts as an Artificial Enzyme: Their Application to Catalytic Enantioselective Reactions. Y. Takemoto, J. Synth. Org. Chem. Jpn., 64 (11), 1139-1147 (2006).

・C-N Bond Formation through Amination. In Comprehensive Organometallic Chemistry III. Y. Takemoto, H. Miyabe; Eds. Crabtree, R. H.; Mingos, D. M. P.; Elsevier: Oxford, Vol. 10.15, 695-724. (2006).

・ Reaction of Nitro Organic Compounds Using Thiourea Catalysts Anchored to Polymer Support. H. Miyabe, S. Tuchida, M. Yamauchi, Y. Takemoto, Synthesis, (19), 3295-3300 (2006).

・ Enantioselective Cascade Radical Addition-Cyclization-Trapping Reactions. H. Miyabe, R. Asada, A. Toyoda, Y. Takemoto, Angew. Chem. Int. Ed., 45 (35), 5863-5866 (2006).

・Thiourea-Catalyzed Asymmetric Michael Addition of Activated Methylene Compounds to????-Unsaturated Imides: Dual Activation of Imide by Intra- and Intermolecular Hydrogen-bonding. T. Inokuma, Y. Hoashi, Y. Takemoto, J. Am. Chem. Soc., 128 (29), 9413-9419 (2006).

・ Palladium-Catalyzed Intramolecular Cyanoamidation of Alkynyl and Alkenyl Cyanoformamides. Y. Kobayashi, H. Kamisaki, R. Yanada, Y. Takemoto, Org. Lett., 8 (13), 2711-2713 (2006).

・ Efficient Synthesis of Indoles Using [3,3]-Sigmatropic Rearrangement of N-Trifluoroacetyl Enehydrazines. O. Miyata, N. Takeda, Y. Kimura, Y. Takemoto, N. Tohnai, M. Miyata, T. Naito, Tetrahedron, 62 (15), 3629-3647 (2006).

・ In(OTf)₃-catalyzed Tandem Nucleophilic Addition and Cyclization of ortho-Alkynylarylaldimines to 1,2-Dihydroisoquinolines. R. Yanada, S. Obika, H. Kono, Y. Takemoto, Angew. Chem. Int. Ed., 45 (23), 3822-3825 (2006).

・ Reactive Ketimino Radical Acceptors: Intermolecular Alkyl Radical Addition to Imines with a Phenolic Hydroxyl Group. H. Miyabe, Y. Yamaoka, Y. Takemoto, J. Org. Chem., 71 (5), 2099-2106 (2006).

・ Organocatalytic Enantioselective Hydrazination of 1,3-Dicarbonyl Compounds: Asymmetric Synthesis of α,α-Disubstituted α-Amino Acids. X. Xu, T. Yabuta, P. Yuan, Y. Takemoto, Synlett, (1), 137-140 (2006).
・ Bifunctional Thiourea-Catalyzed Diastereo- and Enantioselective Aza-Henry Reaction. X. Xu, T. Furukawa, T. Okino, H. Miyabe, Y. Takemoto, Chem. Eur. J., 12, 466-476 (2006).

・ Enantioselective Tandem Michael Reaction to Nitroalkene Catalyzed by Bifunctional Thiourea: Total Synthesis of (-)-Epibatidine. Y. Hoashi, T. Yabuta, P. Yuan, H. Miyabe, Y. Takemoto, Tetrahedron, 62 (2-3), 365-374 (2006).

・ 生物活性物質の迅速合成を指向した金属反応剤によるラクタム形成反応の開発　安井義純, 竹本佳司, 化学工業, 57 (19), 729-733 (2006).

・ チオ尿素系不斉有機分子触媒の創製「有機分子触媒の新展開」　竹本佳司, 監修　柴崎正勝, シーエムシー出版, Tokyo, 167-179 (2006).


2005

・ Enantio- and Diastereoselective Michael Reaction of 1,3-Dicarbonyl Compounds to Nitroolefins Catalyzed by a Bifunctional Thiourea. T. Okino, Y. Hoashi, T. Furukawa, X. Xuenong, Y. Takemoto, J. Am. Chem. Soc., 127 (1), 119-125 (2005).

・ Enantioselective Michael Addition to α,β-Unsaturated Imides Catalyzed by a Bifunctional Organocatalyst. Y. Hoashi, T. Okino, Y. Takemoto, Angew. Chem. Int. Ed., 44 (26), 4032-4035 (2005).

・ Recognition and Activation by Ureas and Thioureas: Stereoselective Reactions Using Ureas and Thioureas as Hydrogen-Bonding Donors. Y. Takemoto, Org. Biomol. Chem., 3 (24), 4299 - 4306 (2005).

・ Regio- and Stereocontrolled Palladium or Iridium-Catalyzed Allylation. H. Miyabe, Y. Takemoto, Synlett, (11), 1641-1655 (2005).

・ A Convenient Synthesis of (E)-α-alkylidene-γ-lactams and (E)-3-alkylideneoxindoles by Rhodium-Catalyzed Intramolecular Hydroamidation, Y. Kobayashi, H. Kamisaki, K. Yanada, R. Yanada, Y. Takemoto, Tetrahedron Lett., 46, 7549-7532 (2005).

・ Stereoselective Synthesis of 3-Alkylideneoxindoles Using Tandem In-Mediated Carbometallation and Pd-Catalyzed Cross-Coupling Reaction. R. Yanada, S. Obika, Y. Kobayashi, T. Inokuma, M. Oyama, Y. Takemoto, Adv. Synth. Cat., 347, 1632-1642 (2005).

・ Stereoselective Synthesis of 3-Alkylideneoxindoles via Palladium-Catalyzed Domino Reactions, R. Yanada, S. Obika, T. Inokuma, K. Yanada, M. Yamashita, S. Ohta, Y. Takemoto, J. Org. Chem. 70 (17), 6972-6975 (2005).

・ New utilization of optically active homoallylamines: Highly stereoselective synthesis of cyclic guanidine and thiourea, R. Yanada, A. Kaieda, K. Yanada, Y. Takemoto, Heterocycles, 66, 101-106 (2005).

・ Selective Synthesis of Allylated Oxime Ethers and Nitrones Based on Palladium-Catalyzed Allylic Substitution of Oximes. H. Miyabe, K. Yoshida, V. K. Reddy, A. Matsumura, Y. Takemoto, J. Org. Chem., 70 (14), 5630-5635 (2005).

・ Triethylborane-Induced Intermolecular Radical Addition to Ketimines. H. Miyabe, Y. Yamaoka, Y. Takemoto, J. Org. Chem., 70 (8), 3324-3327 (2005).

・ Hydroxylamines as Oxygen Atom Nucleophiles in Transition-Metal-Catalyzed Allylic Substitution. H. Miyabe, K. Yoshida, M. Yamauchi, Y. Takemoto, J. Org. Chem., 70 (6), 2148-2153 (2005).

・ Asymmetric Synthetic Study of Macrolactin Analogues. Y. Kobayashi, A. Fukuda, T. Kimachi, M. Ju-ichi, Y. Takemoto, Tetrahedron, 61 (10), 2607-2622 (2005).

・ Synthesis of α,α-Disubstituted Amino Acids Based on Tandem Reaction of Dehydroamino Acid Derivatives. H. Miyabe, R. Asada & Y. Takemoto, Tetrahedron, 61 (1), 385-393 (2005).


2004

・ Antiproliferative Activity of Rhinocanthus nasutus (L.) Kurz Extracts and the Active Moiety, Rhinacanthin C. A. Gotoh, T. Sakaeda, T. Kimura, T. Shirakawa, Y. Wada, A. Wada, T. Kimachi, Y. Takemoto, A. Iida, S. Iwakawa, M. Hirai, H. Tomita, N. Okamura, T. Nakamura, K. Okumura, Biol. Pharm. Bull., 27 (7), 1070-1074 (2004).

・ Bifunctional Thiourea-Catalyzed Enantioselective Double Michael Reaction of γ,δ-Unsaturated -Ketoester to Nitroalkene: Asymmetric Synthesis of (-)-Epibatidine. Y. Hoashi, T. Yabuta, Y. Takemoto, Tetrahedron Lett., 45 (50), 9185-9188 (2004).

・ Asymmetric Synthesis of Macrolactin A Analogue. Y. Kobayashi, A. Fukuda, T. Kimachi, M. Ju-ichi, Y. Takemoto, Tetrahedron. Lett., 45 (4), 677-680 (2004).

・ Free Radical-Mediated Tandem Reaction of Dehydroamino Acid Derivative with π-Allyl Palladium Complex: Synthesis of α,α-Disubstituted Amino Acids. H. Miyabe, R. Asada, K. Yoshida, Y. Takemoto, Synlett, (3), 540-542 (2004).

・ Utility of the Iridium Complex of the Pybox Ligand in Regio- and Enantioselective Allylic Substitution. H. Miyabe, A. Matsumura, K. Moriyama, Y. Takemoto, Org. Lett., 6 (24), 4631-4634 (2004).

・ Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines Having Electron-Withdrawing Substituents. H. Miyabe, A. Matsumura, K. Yoshida, M. Yamauchi, Y. Takemoto, Letters in Organic Chemistry, 1 (2), 119-121 (2004).

・ Novel Synthesis of O-Allylated Oxime Ethers Based on Allylic Substitution with Oximes. H. Miyabe, A. Matsumura, K. Yoshida, M. Yamauchi, Y. Takemoto, Synlett, (12), 2123-2126 (2004).

・ Aqueous Medium Radical Addition to Ketimines with a Phenolic Hydroxyl Group. H. Miyabe, Y. Yamaoka, Y. Takemoto. Synlett, (14), 2597-2599 (2004).

・ Palladium-Indium Iodide-Mediated Allylation and Propargylation of Glyoxylic Oxime Ether and Hydrazone: The Role of Water in Directing the Diastereoselective Allylation. H. Miyabe, Y. Yamaoka, T. Naito, Y. Takemoto, J. Org. Chem., 69 (4), 1415-1418 (2004).

・ Stereodivergent Synthesis of Chiral 2-Alkenylaziridines: Palladium(0)-Catalyzed 2,3-cis-Selective Aziridination and Base-Mediated 2,3-trans-Selective Aziridination. H. Ohno, Y. Takemoto, N. Fujii, T. Tanaka, T. Ibuka, Chem. Pharm. Bull., 52 (1), 111-119 (2004).

・ Enantioselective Aza-Henry Reaction Catalyzed by Bifunctional Organocatalyst. T. Okino, S. Nakamura, T. Furukawa, Y. Takemoto, Org. Lett., 6 (4), 625-627 (2004).

・ Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes: Synthesis and Biological Evaluation. R. Yanada, N. Nishimori, A. Matsumura, S. Obika, H. Mitsuya, N. Fujii, Y. Takemoto, J. Org. Chem., 67 (7), 2417-2422 (2004).

・ Indium-Mediated Radical Cyclization of Iodoalkenes and Iodoalkynes with and without Allylic and Propargylic Leaving Groups. R. Yanada, S. Obika, N. Nishimori, M. Yamauchi, Y. Takemoto, Tetrahedron Lett., 45 (11), 2331-2334 (2004).

・ Stereoselective Synthesis of 3-Alkylideneoxindoles Using Tandem In-Mediated Carbometallation and Pd-Catalyzed Coupling Reaction. R. Yanada, S. Obika, M. Oyama, Y. Takemoto, Org. Lett., 6 (16), 2825-2828 (2004).

・ 分子不斉を構築する機能性分子　竹本佳司　ファルマシア, 40 (6), 499-501 (2004).


2003

・ Enantioselective Michael Reaction of Malonates to Nitroolefins Catalyzed by Bifunctional Organocatalysts. T. Okino, Y. Hoashi, Y. Takemoto, J. Am. Chem. Soc., 125 (42), 12672-12673 (2003).

・ Enantio- and Diastereoselective Ir-Catalyzed Allylic Substitutions for Asymmetric Synthesis of Amino Acid Derivatives. T. Kanayama, K. Yoshida, H. Miyabe, Y. Takemoto, Angew. Chem. Int. Ed., 42 (18), 2054-2056 (2003).

・ Synthetic Studies on Macrolactin A by Using a (Diene)Fe(CO)₃ Complex. A. Fukuda, Y. Kobayashi, T. Kimachi, Y. Takemoto, Tetrahedron, 59 (47), 9305-9313 (2003).

・ Synthesis of β-Substituted α-Amino Acids Using Iridium-Catalyzed Asymmetric Allylic Substitution. T. Kanayama, K. Yoshida, H. Miyabe, T. Kimachi, Y. Takemoto, J. Org. Chem., 68 (16), 6197-6201 (2003).

・ Regioselectivity in Palladium-Indium Iodide-Mediated Allylation Reaction of Glyoxylic Oxime Ether and N-Sulfonylimine. H. Miyabe, Y. Yamaoka, T. Naito, Y. Takemoto, J. Org. Chem., 68 (17), 6745-6751 (2003).

・ Synthesis of azacycles based on Iridium-catalyzed sequential allylic amination. H. Miyabe, K. Yoshida, Y. Kobayashi, A. Matsumura, Y. Takemoto, Synlett, (7), 1031-1033 (2003).

・ O-Allylic Substitution of Hydroxylamine Derivatives Having an N-Electron-Withdrawing Substituent. H. Miyabe, K. Yoshida, A. Matsumura, M. Yamauchi, Y. Takemoto, Synlett, (4), 567-569 (2003).

・ Thiourea-Catalyzed Nucleophilic Addition of TMSCN and Ketene Silyl Acetals to Nitrones and Aldehydes. T. Okino, Y. Hoashi, Y. Takemoto, Tetrahedron Lett., 44 (14), 2817-2821 (2003).

・ Indium-Mediated Tandem Radical Addition-Cyclization-Trap Reactions in Aqueous Media. M. Ueda, H. Miyabe, A. Nishimura, O. Miyata, Y. Takemoto, T. Naito, Org. Lett., 5 (21), 3835-3838 (2003).

・ イミン類への炭素ラジカル付加反応の開発　宮部豪人　薬学雑誌, 123 (5), 285-294 (2003).


2002

・ Asymmetric Synthesis of β^2,3-Amino Acids by InI-Pd(0)-Promoted Metalation and Addition of Chiral 2-Vinylaziridines. M. Anzai, R. Yanada, N. Fujii, H. Ohno, T. Ibuka, Y. Takemoto, Tetrahedron, 58 (26), 5231-5239 (2002).

・ Synthetic Study on CP-263,114 (Phomoidride B) by SET-Mediated Fragmentation. T. Matsushita, H. Ashida, T. Kimachi, Y. Takemoto, Chem. Commun., (8), 814-815 (2002).

・ Pd-Catalyzed Asymmetric Allylic Alkylation of Glycine Iminoester Using a Chiral Phase-Transfer Catalyst. M. Nakoji, T. Kanayama, T. Okino, Y. Takemoto, J. Org. Chem., 67 (21), 7418-7423 (2002).

・ Synthesis of Allenes from Allylic Alcohol Derivatives Bearing a Bromine Atom Using a Palladium(0)/Diethylzinc System. H. Ohno, K. Miyamura, T. Tanaka, S. Oishi, A. Toda, Y. Takemoto, N. Fujii, T. Ibuka, J. Org. Chem., 67 (4), 1359-1367 (2002).

・ Indium-Mediated Atom-Transfer Cyclizations and Reductive Cyclizations. R. Yanada, N. Nishimori, A. Matsumura, N. Fujii, Y. Takemoto, Tetrahedron Lett., 43 (26), 4585-4588 (2002).

・OsO₄-Catalyzed Dihydroxylation of Olefins in Ionic Liquid [emim]BF4: A Recoverable and Reusable Osmium. R. Yanada, Y. Takemoto, Tetrahedron Lett., 43 (38), 6849-6852 (2002).

・ キレーション効果を利用したC−HおよびC−C結合の触媒的活性化　宮部　豪人　化学, 57 (9), 66-67 (2002).


2001

・ Asymmetric Total Synthesis of Halicholactone. Y. Baba, G. Saha, S. Nakao, C. Iwata, T. Tanaka, T. Ibuka, H. Ohishi, Y. Takemoto, J. Org. Chem., 66 (1), 81-88 (2001).

・ Novel Sparteine-Mediated Enantio-Dichotomic Formal Synthesis of (R)-(-)- and (S)-(+)-Curcuphenol. T. Kimachi, Y. Takemoto, J. Org. Chem., 66 (8), 2700-2704 (2001).

・ Chiral Phosphine-Free Pd-Mediated Asymmetric Allylation of Prochiral Enolate with a Chiral Phase-Transfer Catalyst. M. Nakoji, T. Kanayama, T. Okino, Y. Takemoto, Org. Lett., 3 (21), 3329-3331 (2001).

・ Stereoselective Synthesis of 2-Alkenylaziridines and 2-Alkenylazetidines by Palladium-Catalyzed Intramolecular Amination of α- and β-Amino Allenes. H. Ohno, M. Anzai, A. Toda, S. Ohishi, N. Fujii, T. Tanaka, Y. Takemoto, T. Ibuka, J. Org. Chem., 66 (14), 4904-4914 (2001).

・ Role of the Planar Chirality of Chiral Amino Alcohols Bearing Iron Tricarbonyl in Asymmetric Alkylation of Diethylzinc to Aldehydes. K. Okamoto, T. Kimachi, T. Ibuka, Y. Takemoto, Tetrahedron: Asymmtry, 12 (3), 463-467 (2001).

・ Asymmetric Alkylation of tert-Butyl Glycinate Schiff Base with Chiral Quaternary Ammonium Salt under Micellar Conditions. T. Okino, Y. Takemoto, Org. Lett., 3 (10), 1515-1517 (2001).

・ Stereoselective Synthesis of Nonracemic 1,3-Amino Alcohols from Chiral 2-Vinylaziridines by InI-Pd(0)-Promoted Metalation. Y. Takemoto, M. Anzai, R. Yanada, N. Fujii, H. Ohno, T. Ibuka, Tetrahedron Lett., 42 (9), 1725-1728 (2001).

・ Stereospecific 1,3-Migration of an Fe(CO)₃ Group on Acyclic Conjugated Polyenes: Application to Remote and Iterative Asymmetric Induction. Y. Takemoto, K. Ishii, T. Ibuka, Y. Miwa, T. Taga, S. Nakao, T. Tanaka, H. Ohishi, Y. Kai, N. Kanehisa, J. Org. Chem., 66, 6116-6123 (2001).

・ Diastereoselective Barbier-Type and Palladium-Mediated Allylaion of Optically Active Aldimine with Allylindium Reagents. R. Yanada, A. Kaieda, Y. Takemoto, J. Org. Chem., 66 (22), 7516-7518 (2001).

・ Aluminum-Controlled Reactivity and Diastereoselectivity Toward Radical Reactions of Optically Active Aldimines with Metallic Samarium. R. Yanada, M. Okaniwa, A. Kaieda, T. Ibuka, Y. Takemoto, J. Org. Chem., 66 (4), 1283-1286 (2001).


2000

・ Stereoselective Synthesis of Chiral Amino Allenes by Organocopper-Mediated anti SN2'-Substitution Reaction of Chiral Ethynylaziridines. H. Ohno, A. Toda, N. Fujii, Y. Takemoto, T. Tanaka, T. Ibuka, Tetrahedron, 56 (18), 2811-2820 (2000).

・ Novel Synthesis of Chiral Terminal Allenes via Palladium(0)-Catalyzed Reduction of Mesylates of 2-Bromoalk-2-en-1-ols Bearing a Protected Amino Group, Using Diethylzinc. H. Ohno, A. Toda, S. Oishi, T. Tanaka, Y. Takemoto, N. Fujii, T. Ibuka, Tetrahedron Lett., 41 (26), 5131-5134 (2000).

・ Asymmetric Total Synthesis of Halicholactone. Y. Takemoto, Y. Baba, G. Saha, S. Nakao, C. Iwata, T. Tanaka, T. Ibuka, Tetrahedron Lett., 41 (19), 3653-3656 (2000).

・ Remote Asymmetric Induction by Using 1,3-Migration Reaction of (Diene)iron Tricarbonyl Complexes. Y. Takemoto, K. Ishii, A. Honda, K. Okamoto, R. Yanada, T. Ibuka, Chem. Commun., 1445-1446 (2000).

・ Enantioselective Addition of Diethylzinc to Aldehydes with Novel Chiral C2-Symmetric Dimeric Ligands. M. Okaniwa, R. Yanada, T. Ibuka. Tetrahedron Lett. 41 (7), 1047-1050 (2000).

・ Stereospecific 1,3-Migration of an Fe(CO)₃ Group on Acyclic Conjugated Trienes Bearing an Electron-Withdrawing Group. Y. Takemoto, K. Ishii, Y. Miwa, T. Taga, T. Ibuka, S. Nakao, T. Tanaka, Tetrahedron Lett., 41 (1), 85-88 (2000).

・ オキシムエーテルをラジカル受容体とした固相ラジカル反応の開発　宮部　豪人　薬学雑誌, 120 (8), 667-676 (2000).

・ アルデヒドやケトンをラジカル受容体とするには　宮部　豪人　ファルマシア, 36, 407-408 (2000).

・ 金属サマリウムを利用する合成反応の開発　柳田玲子, 井深俊郎　有機合成化学協会誌, 58 (6), 597-605 (2000).


1999

・Utility of A Diene-tricarbonyliron Complex as A Mobile Chiral Auxiliary: Regio- and Stereocontrolled Functionalization of Acyclic Diene Ligands. Y. Takemoto, N. Yoshikawa, Y. Baba, C. Iwata, T. Tanaka, T. Ibuka, H. Ohishi, J. Am. Chem. Soc., 121 (39), 9143-9154 (1999).

・ Synthesis of Chiral Amino Allenes via an Organocyanocuprate-Mediated Ring-Opening Reaction of Enantiopure Ethynylaziridines. H. Ohno, A. Toda, Y. Miwa, T. Taga, N. Fujii, T. Ibuka, Tetrahedron Lett., 40 (2), 349-352 (1999).

・ Stimulation of Nerve Growth Factor Synthesis/Secretion by 5-Deazaflavoquinone in Mouse Astrocytes. Tanigawa, H. Ohde, F. Yoneda, T. Kimachi, M. Toyomoto, S. Inoue, K. Ikeda, K. Hayashi, J. Biochem. Mol. Bio. & Biophys., 3, 231-237 (1999).

・ Sterically Congested Chiral Activated Aziridines: Synthesis of Both 2,3-Cis- and 2,3-Trans-2-Alkenyl-3-alkylaziridines from Common Intermediates. H. Ohno, A. Toda, N. Fujii, Y. Miwa, T. Taga, Y. Yamaoka, E. Osawa, T. Ibuka, Tetrahedron Lett., 40 (7), 1331-1334 (1999).

・ First Palladium-Catalyzed Aziridination Reaction of Amino Allenes. H. Ohno, A. Toda, Y. Miwa, T. Taga, N. Fujii, T. Ibuka, J. Org. Chem., 64 (9), 2992-2993 (1999).

・ Regiospecific Ring-Opening Reactions of β-Aziridinyl α,β-Enoates with Acids: Application to the Stereoselective Synthesis of a Couple of Diastereoisomeric (E)-Alkene Dipeptide Isosteres from a Single β-Aziridinyl α,β-Enoate and to the Convenient Preparation of Amino Alcohols Bearing α,β-Unsaturated Ester Groups. H. Tamamura, M. Yamashita, Y. Nakajima, K. Sakano, A. Otaka, H. Ohno, T. Ibuka, N. Fujii, J. Chem. Soc., Perkin Trans. 1, (20), 2983-2996 (1999).

・ Palladium-Catalyzed Regio- and Stereoselective Synthesis of N-Protected 2,4-Dialkylated Azacyclobutanes from Amino Allenes. M. Anzai, A. Toda, H. Ohno, Y. Takemoto, N. Fujii, T. Ibuka, Tetrahedron Lett., 40 (41), 7393-7397 (1999).

・ Selective Synthesis of Nonracemic 3-Pyrrolines and 2,3-Cis-2-vinylaziridines from (Z)-Amino Allylic Alcohols: A New Synthetic Route to Chiral 3,4-Dehydroproline. K. Ishii, H. Ohno, Y. Takemoto, T. Ibuka, Synlett, (2), 228-230 (1999).

・ Selective Synthesis of Cis-2-vinyl-3-alkylaziridines and 3-Pyrrolines from Common Intermediates (Z)-4-N-Arylsulfonylaminoalk-2-en-1-ols. K. Ishii, H. Ohno, Y. Takemoto, E. Osawa, Y. Yamaoka, N. Fujii, T. Ibuka, J. Chem. Soc., Perkin Trans.1, (15), 2155-2163 (1999).

・ Convenient Syntheses of Chiral 3-Substituted 2-Ethynylaziridines. H. Ohno, A. Toda, Y. Takemoto, N. Fujii, T. Ibuka, J. Chem. Soc., Perkin Trans. 1, (20), 2949-2962 (1999).

・ CAN Induced Double Ether Ring Formation: Synthesis of Trans- and Cis-fused Tricyclic Ethers from 3-Oxabicyclo[3.1.0]hexyl Sulfides. Y. Takemoto, S.-i. Furuse, H. Hayase, T. Echigo, C. Iwata, T. Tanaka, T. Ibuka, Chem. Commun., (24), 2515-2516 (1999).

・ Diastereoselective Allylation and Alkylation of Optically Active Imines with Metallic Samarium and A Catalytic Amount of Iodine. R. Yanada, N. Negoro, M. Okaniwa, T. Ibuka, Tetrahedron, 55 (49), 13947-13956 (1999).

・ Samarium-Promoted Diastereoselective Reductive Coupling of Optically Active Imines. R. Yanada, N. Negoro, M. Okaniwa, Y. Miwa, T. Taga, K. Yanada, T. Fujita, Synlett, (5), 537-540 (1999).

・ Sparteine-Mediated Enantioselective [2,3]-Wittig Rearrangement of Allyl ortho-Substituted Benzyl Ethers and ortho-Substituted Benzyl Prenyl Ethers. T. Kawasaki, T. Kimachi, Tetrahedron, 55 (22), 6847-6862 (1999).