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Bando H, Nishio T, van der Horst GTJ,
Masubuchi S, Hisa Y, Okamura H: Vagal regulation of airway
clocks in mice. J. Neurosci.,
27, 4359-4365, 2007.
Cheng H-YM, Papp JW, Verlamova O, Dziema H, Russell B, Curfman
JP, Nakazawa T, Shimizu K, Okamura H, Impey S, Obrietan K:
MicroRNA modulation of circadian clock period and entrainment. Neuron,
54:813-829, 2007. |
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Masamizu Y, Ohtsuka T, Takashima Y, Nagahara
H, Takenaka Y, Yoshikawa K, Okamura H, Kageyama R: Real-time
imaging of the somite segmentation clock: reveration of
unstable oscillators in the individual presomitic mesoderm
cells. Proc. Natl. Acad. Sci. USA.
103, 1313-1318, 2006.
Chaves I, Yagita K, Barnhoon S, Okamura H, van der Horst
TJ, Tamanini F: Functional evolution of the photolyase/chryptochrome
protein family: importance of the C terminus of mammalian
CRY1 for circadian core oscillator performance, Mol.
Cell. Biol., 26, 1743-1753, 2006.
Koyanagi S, Okazawa S, Kuramoto Y, Ushijima K, Shimeno H,
Soeda S, Okamura H, Ohdo S: Chronic treatment with prednisolone
represses the circadian oscillation of clock gene expression
in mouse peripheral tissues. Mol. Endocrinol. 20,
573-583, 2006.
Maywood ES, Reddy AB, Wong GKY, O’Nelill JS, O'Brien JA,
McMahon DG, Harmar AJ, Okamura H, Hastings MH: Synchronization
and maintenance of timekeeping in suprachiasmatic circadian
clock cells by neuropeptidergic signaling. Current
Biology 16, 599-605, 2006.
Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto
M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara
K, Katayose K, Okamura H, Kahn CR, Noda T, Takeda K, Akira
S, Inui A, Kasuga M: Role of hepatic STAT3 in brain insulin
action on hepatic glucose production, Cell Metabolism.
3, 267-275, 2006.
Fujimoto Y, Yagita K, Okamura H: Does mPER2 protein oscillate
without its coding mRNA cycling?-- Post-transcriptional
regulation by cell clock, Genes Cells, 11,
525-530, 2006.
Maeda A, Tsujiya S, Higashide T, Toida K, Todo T, Ueyama
T, Okamura H, Sugiyama K: Circadian intraocular pressure
rhythm is generated by clock genes. Invest. Ophtalmol.
Vis Sci., 47, 4050-4052, 2006.
Hashimoto N, Kido Y, Uchida T, Asahara S, Shigeyama Y, Matsuda
T, Takeda A, Tsuchihashi D, Nishizawa A, Ogawa W, Fujimoto
Y, Okamura H, Karen C. Arden KC, Herrera P, Noda T, and Kasuga
M: Ablation of PDK1 in pancreatic
β cells induces diabetes
as a result of loss of ß-cell mass. Nature
Genetics, 38, 589-593, 2006.
Koshimizu T, Nasa Y, Tanoue A, Oikawa R, Kawahara Y, Kiyono
Y, Adachi T, Tanaka T, Kuwaki T, Mori T, Takeo S, Okamura
H, and Tsujimoto G, V1a vasopressin receptors maintain normal
blood pressure by regulating circulating blood volume and
baroreflex sensitivity. Proc. Natl. Acad. Sci.
USA, 103, 7807-7812, 2006. |
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Ishida A, Mutoh T, Ueyama T, Bando H,
Masubuchi S, Nakahara D, Tsujimoto G, Okamura H: Light
activates the adrenal gland: Timing of gene expression
and glucocorticoid release. Cell Metabolism,
2, 297-307, 2005.
Masubuchi S, Kataoka N, Sassone-Corsi P, Okamura H: Mouse
Period1 (mPER1) acts as a circadian adapter to entrain the
oscillator to environmental light/dark cycles by regulating
mPER2 protein. J. Neurosci., 25,
4719-4724, 2005.
Yamamoto Y, Yagita Y, Okamura H: Role of cyclic mPer2 expression
in mammalian cellular clock. Mol. Cell Biol.,
25, 1912-1921, 2005.
Masuki S., Todo T, Nakano Y, Okamura H, Nose H: Reduced alpha-adrenoceptor
responsiveness and enhanced baroreflex sensitivity in Cry-deficient
mice lacking biological clock. J. Physiology
(London), 566, 213-224, 2005.
Saifur Rohman M, Emoto N, Nonaka H, Okura R, Nishimura M,
Yagita K, van der Horst GT, Matsuo M, Okamura H, Yokoyama
M: Circadian clock genes directly regulate expression of
the Na+/H+ exchanger NHE3 in the kidney. Kidney
Int., 67, 1410-1419, 2005.
Iijima M, Yamaguchi S, van der Horst GT, Bonnefont X, Okamura
H, Shibata S. Altered food-anticipatory activity rhythm in
Cryptochrome-deficient mice. Neurosci Res.,
52, 166-173, 2005.
Tamanini F, Yagita K, Okamura H, van der Horst GT. Nucleocytoplasmic
shuttling of clock proteins. Methods Enzymol.,
393, 418-435, 2005.
Okamura H: Biological clock in the liver. In Signaling
Pathways in Liver Dieseases, Edited by J.-F. Dufour
and P.-A. Clavien, Springer-Verlag, Berlin, 2005, pp 391-403. |
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Okamura H: Clock genes and cell clocks:
Roles, actions and mysteries. J. Biol. Rhythms, 19,
388-399, 2004.
Okamura H: Circadian clock: from clock genes to biological
rhythms. In Pituitary Function through the Ages, Edited
by R. Ross and E.M. Erfurth, BioScientifica, Bristol, 2004,
pp 15-29. |
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Matsuo T, Yamaguchi S, Mitsui S, Emi A,
Shimoda F, Okamura H: Control mechanism of the circadian
clock for timing of cell division. Science,
302, 255-259, 2003.
Yamaguchi S, Isejima H, Matsuo T, Okura
R, Yagita K, Kobayashi M, Okamura H: Synchronization
of cellular clocks in the suprachiasmatic nucleus. Science 302,
1408-1412, 2003.
Terazono H, Mutoh T, Yamaguchi S, Kobayashi
M, Akiyama M, Udo R, Ohdo S, Okamura H, Shibata S: Adrenergic
regulation of clock gene expression in the mouse liver. Proc.
Natl. Acad Sci. USA, 100, 6795-6800, 2003.
Nakahara D, Nakamura M, Iigo M, Okamura H:
Bimodal circadian secretion of melatonin from the pineal
gland in a living CBA mouse. Proc. Natl. Acad.
Sci. USA, 100,9584-9589,2003.
Sujino M, Matsumoto K, Yamaguchi S, van der
Horst G, Okamura H*, Inouye SIT*: Suprachiasmatic nucleus
grafts restore circadian behavioral rhythms of genetically
arrythmic mice. Current Biology,
13, 664-668, 2003. (*corresponding authors)
Mutoh T, Shibata S, Korf HW, Okamura H: Melatonin
modulates the light-induced sympathoexcitation and vagal
suppression with participation of the suprachiasmatic nucleus
in mice. J. Physiol. (London),
547, 17-332, 2003.
Okamura H: Integration of mammalian circadian
clock signals: from molecule to behavior. J.
Endocrinol., 177, 3-6, 2003.
Nishimura M, Yamagata K, Sugiura H, Okamura
H: The activity-regulated cytoskelton-associated (arc)
gene is a new light-inducible early gene in the mouse suprachiasmatic
nucleus. Neuroscience, 116, 1141-1147,
2003.
Harasawa I, Honda K, Tanoue A, Shinoura H,
Ishida Y, Okamura H, Murao N, Tsujimoto G, Higa K, Kamiya
H, Takano Y: Responses to noxious stimuli in mice lacking α1d-adrenergic
receptors. Neuroreport 14, 1857-1860,
2003.
Nomura K, Takeuchi Y, Yamaguchi S, Okamura
H, Fukunaga K: Involvement of calcium/calmodulin-dependent
protein kinase II in the induction of mPer1. J.
Neurosci. Res., 72, 384-92, 2003.
Kawamoto K, Nagano M, Kanda F, Chihara K,
Shigeyoshi Y, Okamura H: Two types of VIP neuronal components
in rat suprachiasmatic nucleus. J. Neurosci.
Res. 74, 852-857, 2003.
Kimura H, Dong X, Yagita K, Okamura H: Brain
expression of apurinic/apyrimidinic endonuclease (APE/Ref-1)
multifunctional DNA repair enzyme gene in the mouse with
special reference to the suprachiasmatic nucleus. Neurosci.
Res., 46, 443-452, 2003.
Okamura H: Integration of molecular rhythms
in the mammalian circadian system. In Molecular Clocks
and Light Signaling. Novartis Foundation Symposium
253, Edited by D.J. Chadwick and J.A. Goode,
John Wiley & Sons Ltd., Chichester, pp161-170, 2003. |
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Yagita K, Dong X, Tamanini F, Yasuda M,
Hoeijmakers JHJ, van der Horst GTJ, Okamura H: Neucleocytoplasmic
shutting and mCRY-dependent inhibition of ubiquitinaion
of the mPER2 clock protein. EMBO J.,
21, 1301-1314, 2002.
Shigeyoshi Y, Meyer-Bernstein E, Yagita
K, Weili F, Chen Y, Takumi T, Schotland P, Sehgal A,
Okamura H: Restration of circadian behavioral rhythms
in a period null drosophila mutant (per01)
by mammalian period homologues mPer1 and mPer2. Genes
Cells, 7, 163-171, 2002.
Okamura H, Yamaguchi S, Yagita K: Molecular
machinery of the circadian clock in mammals. Cell
Tissue Res., 309, 47-56, 2002.
Maywood E.S, Okamura H, Hasting MH: Opposing
actions of meuropeptide Y and light on the expression of
circadian clock genes in the mouse suprachiasmatic nuclei. Eur.
J. Neurosci., 15, 216-220, 2002.
Yan L, Okamura H: Gradients in the circadian
expression of Per1 and Per2 genes in
the rat supraciasmatic nucleus. Eur. J. Neurosci.,
15, 1153-1162, 2002.
Onishi H, Yamaguchi S, Yagita K, Ishida Y,
Dong X, Kimura H, Jing Z, Ohara H, Okamura H: Rev-erbα gene
expression in the mouse brain with special emphasis on
its circadian profiles in the suprachiasmatic nucleus. J.
Neurosci. Res., 68, 551-557, 2002.
Ishida Y, Yokoyama C, Inatomi T, Yagita K,
Dong X, Yan L, Yamaguchi S, Nagatsu I, Komori T, Kitahama
K, Okamura H: Circadian rhythm of aromatic L-amino acid
decarboxylase in the rat suprachiasmatic nucleus: gene
expression and decarboxylating activity in clock oscillating
cells. Genes Cells, 7, 447-459,
2002. |
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Yagita K, Tamanini F, van der Horst GTJ,
Okamura H., Molecular mechanisms of the biological clock
in Cultured fibroblasts. Science, 292,
278-292, 2001.
Yamaguchi, S., Kobayashi, M., Mitsui, S.,
Ishida, Y., van der Horst, G.T.J., Suzuki, M., Shibata,
S., Okamura, H.: Real time monitoring of clock gene expression
in the living mouse. Nature,
409, 684, 2001.
Mitsui S, Yamaguchi S, Matsuo T, Ishida Y,
Okamura H., Antagonistic role of E4BP4 and PAR proteins
in the circadian oscillatory mechanism. Genes
Develop., 15, 995-1006, 2001.
Asai, M, Yamaguchi S, Isejima H, Jonouchi
M, Takahiro Moriya T, Shibata S, Masaki Kobayashi M, Okamura
H., Visualization of mPer1 transcription in
vitro: NMDA induces a rapid phase-shift of mPer1 gene
in cultured SCN. Current Biology, 11,
1524-1527, 2001.
Yamamoto S, Shigeyoshi Y, Ishida Y, Fukuyama
T, Yamaguchi S, Yagita K, Moriya Y, Shibata S, Yakashima
N, Okamura H., Expression of the Per1 gene in
the hamster: Brain atlas and circadian characteristics
in the suprachiasmatic Nucleus. J. Comp. Neurol.,
430, 518-532, 2001.
Wakamatsu H, Takahashi S, Moriya T, Inouye
S-IT, Okamura H, Akiyama M, Shibata S., Additive effect
of mPer1 and 2 antisense oligonucleotides on light-induced
phase shift. Neuroreport, 12,127-131,
2001.
Nakamura T, Shigeyoshi Y, Maebayashi Y, Yamaguchi
S, Yagita K, Okamura H., Different developmental profiles
of the expression of preprosomatostatin and preprotachykinin-A
mRNAs in rat SCN neurons. Dev. Brain Res.,
127, 81-86, 2001.
Ishida Y, Yagita K, Fukuyama T, Nishimura
M, Nagano M, Shigeyoshi Y, Yamaguchi S, Komori T, Okamura
H., Constitutive expression and delayed light response
of casein kinase Ie and Id mRNAs in the mouse suprachiasmatic
nucleus. J. Neurosci. Res., 64,
612-616, 2001.
Nonaka H, Emoto N, Ikeda K, Fukuya H, Saifur
RM, Raharjo SB, Yagita K, Okamura H, Yokoyama M., Angiotensin
II induces circadian gene expression of clock genes in
cultured vascular smooth muscle cells. Circulation, 104,
1746-1748, 2001. |
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Yagita K, Yamaguchi S, Tamanini F, van
der Horst GTJ, Hoeijmakers JHJ, Yasui A, Loros JJ, Dunlap
JC, Okamura H., Dimerization and nuclear entry of mPER
proteins in mammalian cells. Genes Develop. 14:1353-1363,
2000.
Yamaguchi S, Mitsui S, Yan L, Yagita K,
Miyake S, Okamura H., Role of DBP in the circadian oscillatory
mechanism. Mol. Cell. Biol. 20:4773-4781,
2000.
Yan L, Miyake S, Okamura H., Distribution
and circadian expression of dbp in SCN and extra-SCN areas
in the mouse brain. J. Neurosci. Res.,
59:291-295, 2000.
Yagita K, Okamura H., Forskolin induces circadian
gene expression of rPer1, rPer2 and dbp
in mammalian rat-1 fibroblasts. FEBS Lett. 465:79-82,
2000.
Horikawa K, Yokota S, Fuji K, Akiyama M,
Moriya T, Okamura H, Shibata S., Non-photic entrainment
by 5-HT1A/7 receptor agonists accompanying with reduction
of Per1 and Per2 expression. J.
Neurosci. 20: 5867-5873, 2000.
Takekida S, Maywood E, Hastings M, Okamura
H., Differential adrenergic regulation of the circadian
expression of the clock genes Period1 and Period2 in
the rat pineal gland. Eur. J. Neurosci.,
12: 4557-4551, 2000. |
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Okamura H, Miyake S, Sumi Y, Yamaguchi
S, Yasui A, Muijtjens M, Hoeijmakers JHJ, van der Horst
GTJ., Photic induction of mPer1 and mPer2 in Cry-deficient
mice lacking a biological clock. Science, 286:2531-2534,
1999.
Maebayashi Y, Shigeyoshi Y, Takumi T, Okamura
H., A putative transcription factor with seven zinc-finger
motif identified in the developing suprachiasmatic nucleus
by the differential display-PCR method. J.
Neurosci. , 19:10176-10183, 1999.
Yan L, Takekida S, Shigeyoshi Y, Okamura
H., Per1 and Per2 gene expression in
the rat suprachiasmatic nucleus: circadian profile and
the compartment-specific response to light. Neuroscience, 94:141-150,
1999.
Takumi T, Nagamine Y, Miyake S, Matsubara
C, Taguchi K, Takekida S, Sakakida Y, Nishikawa K, Kishimoto
T, Niwa S, Okumura K, Okamura H., A mammalian orthologue
of Drosophila timeless, highly expressed in SCN and retina,
forms a complex with mPER1. Genes Cells, 4:
67-75, 1999.
Ibata Y, Okamura H, Tanaka M, Tamada Y, Hayashi
S, Iijima N, Matsuda T, Takamatsu T, Hisa Y, Shigeyoshi
Y, Amaya F., Functional morphology of the suprachiasmatic
nucleus. Front. Neuroendocrinol.,
20:241-268, 1999. |
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Takumi T, Taguchi K, Miyake S, Sakakida
Y, Takashima N, Matsubara C, Maebayashi Y, Okumura K, Takekida
S, Yamamoto S, Yagita K, Yan L, Young ML, Okamura, H: A
light independent oscillatory gene mPer3 in mouse
SCN and OVLT. EMBO J., 17: 4753-4759,
1998.
Tamada Y, Tanaka M, Munekawa K, Hayashi
S, Okamura H, Kubo T, Hisa Y, Ibata Y: Neuron-glia interaction
in the suprachiasmatic nucleus: a double labeling light
and electron microscopic immunocytochemical study in
the rat. Brain Res. Bull.,
45: 281-287, 1998.
Takumi T, Matsubara C, Shigeyoshi Y, Taguchi
K., Yagita K, Maebayashi Y, Sakakida Y, Okumura K, Takashima
N, Okamura H: A new mammalian Period gene predominantly
expressed in the suprachiasmatic nucleus. Genes
Cells, 3: 167-176, 1998. |
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Shigeyoshi Y, Taguchi K,
Yamamoto S, Takekida S, Yan L, Tei H, Moriya T, Shibata
S, Loros JL, Dunlap JC., Okamura H: Light-induced resetting
of a mammalian circadian clock is associated with rapid
induction of the mPer1 transcript. Cell, 91:
1043-1053, 1997.
Tei H, Okamura H, Shigeyoshi, Y., Fukuhara
C, Ozawa R, Hirose M, Sakaki Y: Circadian oscillation
of a mammalian homologue of the Drosophila period gene. Nature,
389, 512-516, 1997.
Ban Y, Shigeyoshi Y, Okamura H: Development
of circadian VIP rhythm in the rat suprachiasmatic nucleus. J.
Neurosci., 17, 3920-3931, 1997.
Tanaka M, Amaya F, Tamada Y, Okamura H, Hisa
Y, Ibata Y: Induction of NGFI-A gene expression in the
rat suprachiasmatic nucleus by photic stimulation. Brain
Res., 756: 305-310, 1997.
Shigeyoshi Y., Maebayashi H, Okamura H: Coexistence
of preprosomatostatin and preprotachykinin A mRNA in neurons
of the rat suprachiasmatic nucleus. Mol. Brain
Res., 48: 159-163, 1997.
Tanaka M, Matsuda T, Shigeyoshi Y, Ibata
Y, Okamura H: Peptide expression in GABAergic neurons in
rat suprachiasmatic nucleus in comparison with other forebrain
structures: a double-labeling in situ hybridization study. J.
Histochem. Cytochem., 45: 1-7, 1997.
Ibata Y, Tanaka M, Tamada Y, Hayashi S, Kawakami F, Takamatsu
T, Okamura H: The suprachiasmatic nucleus: A circadian
oscillator. Neuroscientist, 3:
215-225, 1997. |
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