{"id":68,"date":"2025-04-03T16:07:42","date_gmt":"2025-04-03T07:07:42","guid":{"rendered":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/?page_id=68"},"modified":"2026-04-16T12:19:36","modified_gmt":"2026-04-16T03:19:36","slug":"%e7%a0%94%e7%a9%b6%e7%b4%b9%e4%bb%8b","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/%e7%a0%94%e7%a9%b6%e7%b4%b9%e4%bb%8b\/","title":{"rendered":"\u7814\u7a76\u7d39\u4ecb"},"content":{"rendered":"

\u79c1\u305f\u3061\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\uff0c\u751f\u4f53\u819c\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u6a5f\u80fd\u6027\u30da\u30d7\u30c1\u30c9\u3092\u7528\u3044\u305f\u6297\u4f53\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u85ac\u7269\u306e\u7d30\u80de\u5185\u9001\u9054\u306e\u65b0\u6982\u5ff5\u306e\u6a39\u7acb\u3068\u7d30\u80de\u5185\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u306e\u8abf\u7bc0\u3084\u85ac\u7269\u9001\u9054\u3078\u306e\u5c55\u958b\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n

1. \u7d30\u80de\u5185\u6297\u4f53\u9001\u9054\u30da\u30d7\u30c1\u30c9L17E\u3068\u985e\u7e01\u4f53<\/strong><\/span>
\n\u30ab\u30c1\u30aa\u30f3\u6027\u3068\u4e21\u89aa\u5a92\u6027\u3092\u3068\u3082\u306b\u6709\u3059\u308b\u30da\u30d7\u30c1\u30c9\u306e\u591a\u304f\u306f\u9ad8\u3044\u819c\u6eb6\u89e3\u6027\u3092\u793a\u3057\u307e\u3059\uff0e\u3053\u306e\u819c\u6eb6\u89e3\u6027\u306e\u767a\u63ee\u306b\u306f\u30da\u30d7\u30c1\u30c9\u3068\u819c\u3068\u306e\u758e\u6c34\u6027\u76f8\u4e92\u4f5c\u7528\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u3057\u307e\u3059\uff0e\u79c1\u305f\u3061\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\uff0c\u3053\u306e\u758e\u6c34\u6027\u76f8\u4e92\u4f5c\u7528\u3092\u9069\u5207\u306b\u6e1b\u5f31\u3057\u305f\u30da\u30d7\u30c1\u30c9[Attenuated Cationic Amphiphilic Lytic (ACAL) Peptides] \u3092\u5229\u7528\u3057\u305f\u30d0\u30a4\u30aa\u9ad8\u5206\u5b50\u306e\u7d30\u80de\u5185\u9001\u9054\u7cfb\u306e\u69cb\u7bc9\u3092\u8a66\u307f\u3066\u304d\u307e\u3057\u305f\uff0e\u305f\u3068\u3048\u3070\uff0c\u30af\u30e2\u6bd2\u30da\u30d7\u30c1\u30c9M-lycotoxin\u914d\u5217\u4e2d\u306e17\u4f4d\u306e\u758e\u6c34\u6027\u30a2\u30df\u30ce\u9178\u30ed\u30a4\u30b7\u30f3\u3092\u89aa\u6c34\u6027\u30a2\u30df\u30ce\u9178\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306b\u7f6e\u63db\u3057\u305f\u30da\u30d7\u30c1\u30c9L17E\u306f\uff0c\u7d30\u80de\u819c\u306e\u900f\u904e\u6027\u3092\u4e00\u904e\u7684\u306b\u9ad8\u3081\u308b\u4f5c\u7528\u3092\u793a\u3057\u307e\u3059\uff0eL17E\u3084\u305d\u306e\u985e\u7e01\u4f53\u3068\u6297\u4f53\u3092\u540c\u6642\u306b\u7d30\u80de\u57f9\u990a\u6db2\u306b\u6dfb\u52a0\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\uff0cIgG\u6297\u4f53\u3084\u6a5f\u80fd\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5bb9\u6613\u306b\u7d30\u80de\u5185\uff08\u30b5\u30a4\u30c8\u30be\u30eb\uff09\u306b\u9001\u9054\u3055\u308c\u307e\u3059\uff0e
\n\u95a2\u9023\u8ad6\u6587
\nNat. Chem. 2017, 9, 751-761. doi: 10.1038\/nchem.2779
\nAngew. Chem. Int. Ed. 2018, 57, 12771-12774. doi: 10.1002\/anie.201807534.
\nBioconjug. Chem. 2019, 30, 454-460. doi: 10.1021\/acs.bioconjchem.8b00691.
\nMol. Pharm. 2020, 17, 2175-2185. doi: 10.1021\/acs.molpharmaceut.0c00312.
\nMol. Pharm. 2019, 16, 2540-2548. doi: 10.1021\/acs.molpharmaceut.9b00156.
\nAngew. Chem. Int. Ed. 2020, 59, 19990-19998. doi: 10.1002\/anie.202005887.
\nPept. Sci. 2020, 112, e24144. doi: 10.1002\/pep2.24144
\nBioorg. Med. Chem. Lett. 2020, 30, 127362. doi: 10.1016\/j.bmcl.2020.127362.
\nBioorg. Med. Chem. Lett. 2021, 40, 127925. doi: 10.1016\/j.bmcl.2021.127925.
\nBioconjug. Chem. 2021, 32, 950-957. doi: 10.1021\/acs.bioconjchem.1c00101.
\nBioorg. Med. Chem. 2022, 61, 116728. doi: 10.1016\/j.bmc.2022.116728.
\nBioorg. Med. Chem. 2024, 111, 117835. doi: 10.1016\/j.bmc.2024.117835.
\nMol Ther. 2025, 33, 595-614. doi: 10.1016\/j.ymthe.2024.12.050.
\nBioconjug. Chem. 2025, 36, 1683-1697. doi: 10.1021\/acs.bioconjchem.5c00177.<\/p>\n

2. \u30b3\u30a2\u30bb\u30eb\u30d9\u30fc\u30c8\uff08\u30de\u30a4\u30af\u30ed\u6fc3\u7e2e\u4f53\uff09\u3092\u7528\u3044\u308bIgG\u6297\u4f53\u306e\u7d30\u80de\u5185\u9001\u9054<\/strong><\/span>
\n\u79c1\u305f\u3061\u306fL17E\u306e\u591a\u91cf\u4f53\u3068\u8ca0\u306b\u8377\u96fb\u3055\u305b\u305fIgG\u6297\u4f53\u3068\u306e\u6df7\u5408\u306b\u3088\u308a\u76f4\u5f84\u6570\u00b5m\u306e\u6db2\u6ef4\u69d8\u8907\u5408\u4f53\uff08\u30b3\u30a2\u30bb\u30eb\u30d9\u30fc\u30c8\uff0f\u30de\u30a4\u30af\u30ed\u6fc3\u7e2e\u4f53\uff09\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\uff0e\u30de\u30a4\u30af\u30ed\u6fc3\u7e2e\u4f53\u304c\u7d30\u80de\u819c\u3068\u63a5\u3059\u308b\u3068\uff0c\u30de\u30a4\u30af\u30ed\u6fc3\u7e2e\u4f53\u3092\u7d61\u3081\u53d6\u308b\u3088\u3046\u306a\u7d30\u80de\u819c\u306e\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306a\u69cb\u9020\u5909\u5316\u3068IgG\u306e\u7d30\u80de\u5185\u6d41\u5165\u304c\u8a98\u8d77\u3055\u308c\u307e\u3059\uff0e\u79c1\u305f\u3061\u306f\u7a2e\u3005\u306e\u9001\u9054\u7cfb\u306e\u8a2d\u8a08\u3068\u3053\u306e\u73fe\u8c61\u306e\u8a98\u5c0e\u539f\u7406\u306e\u7406\u89e3\u3092\u901a\u3057\u3066\uff0cIgG\u306e\u9ad8\u52b9\u7387\u7d30\u80de\u5185\u9001\u9054\u7cfb\u306e\u6a39\u7acb\u3092\u76ee\u6307\u3059\u3068\u3068\u3082\u306b\uff0c\u7d30\u80de\u6a5f\u80fd\u306e\u8abf\u7bc0\u3084\u533b\u7642\u3078\u306e\u5c55\u958b\u306e\u53ef\u80fd\u6027\u3092\u63a2\u3063\u3066\u3044\u307e\u3059\uff0e
\n\u95a2\u9023\u8ad6\u6587
\nAngew. Chem. Int. Ed. 2021, 60, 19804-19812. doi: 10.1002\/anie.202105527.
\nBioconjug. Chem. 2024, 35, 1888-1899. doi: 10.1021\/acs.bioconjchem.4c00344.
\nBioconjug. Chem. 2025, 36, 494-1503. doi: 10.1021\/acs.bioconjchem.5c00176.
\nAngew. Chem. Int. Ed. 2026, 65, e12139. doi: 10.1002\/anie.202512139.<\/p>\n

3. \u95a2\u9023\u3059\u308b\u7dcf\u8aac\u30fb\u89e3\u8aac<\/strong><\/span>
\nNat. Chem. 2021, 13, 517-519. doi: 10.1038\/s41557-021-00694-2.
\nChem. Pharm. Bull. 2021, 69, 601-607. doi: 10.1248\/cpb.c21-00140.
\nCurr. Opin. Chem. Biol. 2024, 81, 102482. doi: 10.1016\/j.cbpa.2024.102482.
\n\u751f\u5316\u5b66, 2021, 93, 137-140. doi: 10.14952\/SEIKAGAKU.2021.930137.
\n\u819c, 2023, 48, 60-65. doi: 10.5360\/membrane.48.60.
\n\u751f\u5316\u5b66, 2023, 95, 157-160. doi: 10.14952\/SEIKAGAKU.2023.950157<\/p>\n","protected":false},"excerpt":{"rendered":"

\u79c1\u305f\u3061\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\uff0c\u751f\u4f53\u819c\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u6a5f\u80fd\u6027\u30da\u30d7\u30c1\u30c9\u3092\u7528\u3044\u305f\u6297\u4f53\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u85ac\u7269\u306e\u7d30\u80de\u5185\u9001\u9054\u306e\u65b0\u6982\u5ff5\u306e\u6a39\u7acb\u3068\u7d30\u80de\u5185\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u306e\u8abf\u7bc0\u3084\u85ac\u7269\u9001\u9054\u3078\u306e\u5c55\u958b\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\uff0e 1. \u7d30\u80de\u5185\u6297\u4f53\u9001\u9054\u30da\u30d7\u30c1\u30c9 […]<\/p>\n","protected":false},"author":75,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-68","page","type-page","status-publish","hentry"],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/wp-json\/wp\/v2\/pages\/68","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/wp-json\/wp\/v2\/users\/75"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/wp-json\/wp\/v2\/comments?post=68"}],"version-history":[{"count":6,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/wp-json\/wp\/v2\/pages\/68\/revisions"}],"predecessor-version":[{"id":175,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/wp-json\/wp\/v2\/pages\/68\/revisions\/175"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/biomol\/wp-json\/wp\/v2\/media?parent=68"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}