{"id":446,"date":"2013-08-23T16:58:46","date_gmt":"2013-08-23T07:58:46","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=446"},"modified":"2025-02-18T12:27:10","modified_gmt":"2025-02-18T03:27:10","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

2025<\/h2>\n
    \n
  1. Kashiyama R, Watanabe H, Akasaka T, Ono M.<\/span>
    \n<\/span>Novel amyloid-\u03b2 oligomer-targeted fluorescent probes by introducing branched chain into push-pull type dye
    \n<\/span><\/span>Dyes Pigm. <\/em>236 112680 (2025)\u00a0<\/span><\/span>
    \n<\/span><\/span><\/span>DOI: <\/span><\/span>10.1016\/j.dyepig.2025.112680<\/span><\/li>\n
  2. Okuyama C, Inuzuka Y, Takeuchi Y, Asagoe K, Kagawa S, Ito M, Kusano K, Fujita Y, Watanabe H, Ono M, Higashi T.<\/span>
    \n<\/span>Imaging of cardiac amyloidosis using dynamic 18<\/sup>F-FPYBF-2 positron emission tomography<\/span><\/span>
    \n<\/span><\/span>Ann. Nucl. Med.<\/em>
    \n<\/span>DOI: 10.1007\/s12149-024-02010-7<\/span><\/span><\/span><\/li>\n
  3. Nakashima K, Shimohara H, Watanabe H, Ono M.<\/span>
    \n<\/span>Improvement of tumor-to-blood ratio of radioimmunoconjugates by poly(ethyleneimine)-containing chelating agent
    \n<\/span><\/span>Ann. Nucl. Med. <\/em>
    \n<\/span>DOI: 10.1007\/s12149-024-02003-6<\/span><\/span><\/li>\n
  4. Kazuta N, Nakashima K, Tarumizu Y, Sato T, Maya Y, Watanabe H, Ono M.<\/span>
    \n<\/span>Novel Radiotheranostic Ligands Targeting Prostate-Specific Membrane Antigen Based on Dual Linker Approach
    \n<\/span><\/span>Mol. Pharm. <\/em>22(1) 377-386 (2025)\u00a0<\/em>
    \n<\/span>DOI: 10.1021\/acs.molpharmaceut.4c00974<\/span><\/span><\/li>\n<\/ol>\n

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    2025 (Preprint)<\/h2>\n
      \n
    1. Kashiyama R, Watanabe H, Akasaka T, Fujimoto H, Murakami M, Ooe K, Toyoshima A, Nakashima K, Ono M.<\/span>
      \n<\/span>Feasibility of Targeted Alpha Therapy for Alzheimer’s Disease Using 211<\/sup>At-labeled Agent Targeting Amyloid-\u03b2 Aggregates
      \n<\/span><\/span>ChemRxiv<\/em>\u00a0<\/span><\/span>
      \n<\/span><\/span><\/span>DOI: <\/span><\/span>10.26434\/chemrxiv-2025-6qdbr<\/span><\/li>\n<\/ol>\n

      2024<\/h2>\n
        \n
      1. Ishizaka Y, Watanabe H, Ono M.<\/span>
        \n<\/span>Structure-Affinity-Pharmacokinetics Relationships of Novel 18<\/sup>F\u2010Labeled 1,4-Diazepane Derivatives for Orexin 1 Receptor Imaging
        \n<\/span><\/span>J. Med. Chem. <\/em>67(21) 18781-18793 (2024)<\/span>
        \n<\/span>DOI: <\/span>10.1021\/acs.jmedchem.4c01090<\/span><\/span><\/li>\n
      2. Nakano D, Watanabe H, Saito K, Ono M.<\/span>
        \n<\/span>A Novel Bifunctional Chelating Agent for Tyrosine-Specific Radiolabeling of Peptides and Proteins<\/span><\/span>
        \n<\/span><\/span>Bioconjug. Chem. <\/em>35(10) 1577-1586 (2024)
        \n<\/span>DOI: 10.1021\/acs.bioconjchem.4c00363<\/span><\/span><\/span><\/li>\n
      3. Yamaguchi K, Kazuta N, Tsuchihashi S, Watanabe H, Ono M.<\/span>
        \n<\/span>Structure-affinity-pharmacokinetics relationships of 111<\/sup>In-labeled PSMA-targeted ligands with different albumin binders<\/span><\/span>
        \n<\/span><\/span>Nucl. Med. Biol.<\/em> 138-139 108945 (2024)
        \n<\/span>DOI: 10.1016\/j.nucmedbio.2024.108945<\/span><\/span><\/span><\/li>\n
      4. Jinda H, Watanabe H, Nakashima K, Ono M.<\/span>
        \n<\/span>Application of microfluidic devices for automated two-step radiolabeling of antibodies<\/span><\/span>
        \n<\/span>J. Labelled Comp. Radiopharm<\/em>. 67(10) 341-348 (2024)
        \n<\/span>DOI: 10.1002\/jlcr.4119<\/span><\/span><\/span><\/li>\n
      5. Shimizu Y, Ando M, Watanabe H, Ono M.<\/span>
        \n<\/span>Novel technetium-99m-labeled bivalent PSMA-targeting probe based on a hydroxamamide chelate for the diagnosis of prostate cancer<\/span><\/span>
        \n<\/span><\/span>Ann. Nucl. Med. <\/em>38(10) 847-851 (2024)
        \n<\/span><\/em>DOI: 10.1007\/s12149-024-01959-9<\/span><\/span><\/span><\/span><\/li>\n
      6. Kazuta N, Nakashima K, Watanabe H, Ono M.
        \nEffect of Linker Entities on Pharmacokinetics of 111<\/sup>In-Labeled Prostate-Specific Membrane Antigen-Targeting Ligands with an Albumin Binder<\/span>
        \n<\/span>ACS Pharmacol. Transl. Sci. <\/em>7(8) 2401-2413 (2024)
        \nDOI: 10.1021\/acsptsci.4c00257<\/span><\/span><\/span><\/span><\/li>\n
      7. Okuyama C, Higashi T, Ishizu K, Oishi N, Kusano K, Ito M, Kagawa S, Okina T, Suzuki N, Hasegawa H, Nagahama Y, Watanabe H, Ono M, Yamauchi H.<\/span>
        \n<\/span>New objective simple evaluation method\uff53 of amyloid PET\/CT using whole brain histogram and Top20\uff05-Map<\/span><\/span>
        \n<\/span><\/span>Ann. Nucl. Med.<\/em> 38(9) 763-773 (2024)
        \n<\/span>DOI: 10.1007\/s12149-024-01956-y<\/span><\/span><\/span><\/li>\n
      8. Akasaka T, Watanabe H, Ono M.<\/span>
        \n<\/span>Combined strategies for optimizing BODIPY-based near-infrared fluorescent probe targeting A\u03b2 oligomers<\/span><\/span>
        \n<\/span><\/span>Sens. Actuators B Chem. <\/em>417 136132 (2024)
        \n<\/span>DOI: 10.1016\/j.snb.2024.136132<\/span><\/span><\/span><\/li>\n
      9. Nagashima K, Watanabe H, Akasaka T, Ono M.<\/span>
        \n<\/span>Development of triphenylmethane dyes for in vivo fluorescence imaging of A\u03b2 oligomers<\/span><\/span>
        \n<\/span><\/span>ACS Chem. Neurosci.<\/em> 15(11) 2233-2242 (2024)
        \n<\/span>DOI: 10.1021\/acschemneuro.4c00053<\/span><\/span><\/span><\/li>\n
      10. Jinda H, Nakashima K, Watanabe H, Ono M.<\/span>
        \n<\/span>Synthesis and evaluation of cathepsin B-recognizing trifunctional chelating agent to improve tumor retention of radioimmunoconjugates\u00a0<\/span><\/span>
        \n<\/span>J. Labelled Comp. Radiopharm<\/em>. 67(8) 995-304 (2024)\u00a0
        \n<\/span>DOI: 10.1002\/jlcr.4112<\/span><\/span><\/span><\/li>\n
      11. Onoue R, Watanabe H, Ono M.<\/span>
        \n<\/span>Development of novel bi-modal agents based on near-infrared BODIPY-conjugated Hoechst derivatives for combined use in Auger electron and photodynamic cancer therapy<\/span><\/span>
        \n<\/span><\/span>ACS Pharmacol. Transl. Sci. <\/em>7(5) 1395-1403 (2024)
        \n<\/span>DOI: 10.1021\/acsptsci.4c00035<\/span><\/span><\/span><\/li>\n
      12. Kazuta N, Tsuchihashi S, Watanabe H, Ono M.<\/span>
        \n<\/span>Fundamental Evaluation Regarding the Relationship between Albumin-binding and Tumor Accumulation of PSMA-targeting Radioligands<\/span><\/span>
        \n<\/span><\/span>Ann. Nucl. Med.<\/em> 38(7) 574-583 (2024)
        \n<\/span>DOI: 10.1007\/s12149-024-01930-8<\/span><\/span><\/span><\/li>\n
      13. Tsuchihashi S, Nakashima K, Watanabe H, Ono M.<\/span>
        \n<\/span>Synthesis and Evaluation of Novel Trifunctional Chelating Agents for Pretargeting Approach Using Albumin Binder to Improve Tumor Accumulation<\/span><\/span>
        \n<\/span><\/span>Nucl. Med. Biol.<\/em> 132-133 108911 (2024)
        \n<\/span>DOI: 10.1016\/j.nucmedbio.2024.108911<\/span><\/span><\/span><\/li>\n
      14. Watanabe H, Ikawa M, Kakae M, Shirakawa H, Kaneko S, Ono M.<\/span>
        \n<\/span>Synthesis and biological evaluation of radioiodinated benzoxazole and benzothiazole derivatives for imaging myelin in multiple sclerosis<\/span><\/span>
        \n<\/span><\/span>Bioorg. Med. Chem. Lett.<\/em> 103 129691 (2024)
        \n<\/span>DOI: 10.1016\/j.bmcl.2024.129691<\/span><\/span><\/span><\/li>\n
      15. Ono M.<\/span>
        \n<\/span>Radiotheranostics Based on Chemical Control of Radioactivity Pharmacokinetics<\/span><\/span>
        \n<\/span><\/span>YAKUGAKU ZASSHI<\/em> 144 291-297 (2024)
        \n<\/span>DOI: 10.1248\/yakushi.23-00168-3<\/span><\/span><\/span><\/li>\n
      16. Saito H, Watanabe H, Ono M.<\/span>
        \n<\/span>Synthesis and biological evaluation of novel 18<\/sup>F-labeled 2,4-diaminopyrimidine derivatives for detection of ghrelin receptor in the brain<\/span><\/span>
        \n<\/span><\/span>Bioorg. Med. Chem. Lett.<\/em> 99 129625 (2024)
        \n<\/span>DOI: 10.1016\/j.bmcl.2024.129625 <\/span><\/span><\/span><\/li>\n<\/ol>\n

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        2023<\/h2>\n
          \n
        1. Onoue R, Watanabe H, Ono M.<\/span>
          \n<\/span>Synthesis and biological evaluation of bi-modal BODIPY-conjugated Hoechst applicable for Auger-electron and photodynamic cancer therapy<\/span><\/span>
          \n<\/span><\/span><\/span>Bioorg. Med. Chem. Lett. <\/em>96 129534 (2023)
          \n<\/span>DOI: 10.1016\/j.bmcl.2023.129534 <\/span><\/span><\/span><\/span><\/li>\n
        2. Akasaka T, Watanabe H, Ono M.<\/span>
          \n<\/span>In vivo<\/em> Near-Infrared Fluorescence Imaging Selective for Soluble Amyloid \u03b2 Aggregates Using y-Shaped BODIPY Derivative<\/span><\/span>
          \n<\/span>J. Med. Chem.<\/em> 66(20) 14029-14046 (2023)
          \n<\/span>DOI: 10.1021\/acs.jmedchem.3c01057<\/span><\/span><\/span><\/li>\n
        3. Nakashima K, Watanabe H, Ono M.<\/span>
          \n<\/span>Development of Novel Trifunctional Chelating Agents That Enhance Tumor Retention of Radioimmunoconjugates<\/span><\/span>
          \n<\/span>J. Med. Chem.<\/em> 66(18) 12812-12827 (2023)
          \n<\/span>DOI: 10.1021\/acs.jmedchem.3c00472 <\/span><\/span><\/span><\/li>\n
        4. Tsuchihashi S, Nakashima K, Tarumizu Y, Ichikawa H, Jinda H, Watanabe H, Ono M.<\/span>
          \n<\/span>Development of Novel 111<\/sup>In\/225<\/sup>Ac-Labeled Agent Targeting PSMA for Highly Efficient Cancer Radiotheranostics<\/span><\/span>
          \n<\/span>J. Med. Chem.<\/em> 66(12) 8043-8053 (2023)
          \n<\/span>DOI: 10.1021\/acs.jmedchem.3c00346 <\/span><\/span><\/span><\/li>\n
        5. Kazuta N, Watanabe H, Ono M.<\/span>
          \n<\/span>Synthesis and Evaluation of 111<\/sup>In-labeled Tetrapeptide-based Compounds as SPECT Imaging Probes Targeting Granzyme B<\/span><\/span>
          \n<\/span>J. Label. Compd. Radiopharm.<\/em> 66(10) 298-307 (2023)
          \n<\/span>DOI: 10.1002\/jlcr.4045<\/span><\/span><\/span><\/li>\n
        6. Watanabe H, Ide T, Ono M.<\/span>
          \n<\/span>Synthesis and characterization of novel radioiodinated triazole-pyrolidine derivative to detect orexin 2 receptor in the brain<\/span><\/span>
          \n<\/span><\/span>Chem. Pharm.\u00a0Bull.<\/em> 71(3) 234-239 (2023)
          \n<\/span>DOI: 10.1248\/cpb.c22-00770<\/span><\/span><\/span><\/li>\n
        7. Onoue R, Watanabe H, Ono M.<\/span>
          \n<\/span>Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy<\/span><\/span>
          \n<\/span><\/span>Chem. Commun.<\/em> 59 928-931 (2023)
          \n<\/span>DOI: 10.1039\/d2cc05405a<\/span><\/span><\/span><\/li>\n<\/ol>\n

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          2022<\/h2>\n
            \n
          1. Nakagawa K, Watanabe H, Kaide S, Ono M.
            \nStructure-Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as \u03b1-Synuclein Imaging Probes<\/span>
            \n<\/span>ACS Med. Chem. Lett.\u00a0<\/em>13(10) 1598-1605 (2022)<\/span><\/span><\/li>\n
          2. Kaide S, Watanabe H, Iikuni S, Hasegawa M, Ono M.
            \nSynthesis and Evaluation of 18<\/sup>F-Labeled Chalcone Analogue for Detection of \u03b1-Synuclein Aggregates in the Brain Using the Mouse Model<\/span>
            \n<\/span>ACS Chem. Neurosci.<\/em>\u00a013(20) 2982-2990 (2022)<\/span><\/span><\/li>\n
          3. Nakashima K, Iikuni S, Watanabe H, Ono M.
            \nApplication of the Chelator-based Clickable Radiotheranostic Platform to Moderate-molecular-weight Ligands<\/span>
            \n<\/span>ACS Med. Chem. Lett.\u00a0<\/em>13(10) 1642-1647 (2022)<\/span><\/span><\/li>\n
          4. Iikuni S, Ohara T, Watanabe H, Ono M.
            \nStructure-activity relationships and pharmacokinetics of 111<\/sup>In-labeled glucagon-like peptide-1 receptor-targeting exendin-4 derivatives conjugated with albumin binder moieties<\/span>
            \n<\/span>Mol. Pharm.<\/em> 19(8) 2832-2839 (2022)<\/span><\/span><\/li>\n
          5. Iikuni S, Tarumizu Y, Tsuchihashi S, Ohara T, Watanabe H, Ono M.
            \nSynthesis and evaluation of novel 111<\/sup>In-labeled picolinic acid-based radioligands containing an albumin binder for development of radiotheranostic platform<\/span>
            \n<\/span>Mol. Pharm.<\/em> 19(8) 2725-2736 (2022)<\/span><\/span><\/li>\n
          6. Akasaka T, Watanabe H, Kaide S, Iikuni S, Hasegawa M, Ono M.
            \nSynthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as \u03b1-synuclein imaging probes<\/span>
            \n<\/span>Bioorg. Med. Chem. Lett.\u00a0<\/em>64\u00a0128679 (2022)<\/span><\/span><\/li>\n
          7. Iikuni S, Kamei I, Ohara T, Watanabe H, Ono M.
            \nDevelopment of an 111<\/sup>In-Labeled Glucagon-Like Peptide-1 Receptor-Targeting Exendin-4 Derivative that Exhibits Reduced Renal Uptake<\/span>
            \n<\/span>Mol. Pharm.<\/em>\u00a019(3) 1019-1027 (2022)<\/span><\/span><\/li>\n
          8. Saito K, Watanabe H, Iikuni S, Ono M.
            \nDevelopment of novel 67\/68<\/sup>Ga-labeled pyridyl benzofuran derivatives as islet amyloid imaging probes<\/span>
            \n<\/span>Nucl. Med. Biol.<\/em>\u00a0106-107 72-79 (2022)<\/span><\/span><\/li>\n
          9. Watanabe H, Maekawa R, Iikuni S, Kakae M, Matsuo N, Shirakawa H, Kaneko S, Ono M.
            \nCharacterization of Radioiodinated Diaryl Oxadiazole Derivatives as SPECT Probes for Detection of Myelin in Multiple Sclerosis<\/span>
            \n<\/span>ACS Chem. Neurosci.<\/em>\u00a013(3) 363-369 (2022)<\/span><\/span><\/li>\n
          10. Shimizu Y, Koyasu S, Suzukida M, Izumi K, Kidera E, Shindo T, Saga T, Ono M, Takaori-Kondo A, Nakamoto Y.
            \nDevelopment of a novel Indium-111 radiolabeled mogamulizumab targeting CCR4 for imaging adult T-cell leukemia\/lymphoma in vivo<\/span>
            \n<\/span>Ann. Nucl. Med.<\/em>\u00a036(3) 319-326 (2022)<\/span><\/span><\/li>\n
          11. Kaide S, Watanabe H, Iikuni S, Hasegawa M, Itoh K, Ono M.
            \nChalcone Analogue as New Candidate for Selective Detection of \u03b1-Synuclein Pathology<\/span>
            \n<\/span>ACS Chem. Neurosci.<\/em>\u00a013(1) 16-26 (2022)<\/span><\/span><\/li>\n<\/ol>\n

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            2021<\/h2>\n
              \n
            1. Ogawa Y, Kimura H, Fujimoto H, Kawashima H, Toyoda K, Mukai E, Yagi Y, Ono M, Inagaki N, Saji H.
              \nDevelopment of Novel Radioiodinated Exendin-4 Derivatives Targeting GLP-1 Receptor for Detection of \u03b2-cell Mass<\/span>
              \n<\/span>Bioorg. Med. Chem.<\/em>\u00a052 116496 (2021)<\/span><\/span><\/li>\n
            2. Iikuni S, Kitano A, Watanabe H, Ono M.
              \nFeasibility of 99m<\/sup>Tc-hydroxamamide complex based on (iodophenyl)butyric acid as albumin-binding moiety for tumor imaging via in vivo labeling of albumin<\/span>
              \n<\/span>Bioorg. Med. Chem. Lett.<\/em>\u00a053 128417 (2021)<\/span><\/span><\/li>\n
            3. Shimizu Y, Ando M, Iikuni S, Watanabe H, Ono M.
              \nDevelopment of a hydroxamamide-based bifunctional chelating agent to prepare technetium-99m-labeled bivalent ligand probes<\/span>
              \n<\/span>Sci. Rep.<\/em>\u00a011 18714 (2021)<\/span><\/span><\/li>\n
            4. Iikuni S, Tarumizu Y, Nakashima K, Higaki Y, Ichikawa H, Watanabe H, Ono M.
              \nRadiotheranostics using a novel 225<\/sup>Ac-labeled radioligand with improved pharmacokinetics targeting prostate-specific membrane antigen<\/span>
              \n<\/span>J. Med. Chem.<\/em>\u00a064(18) 13429-13438 (2021)<\/span><\/span><\/li>\n
            5. Fujimoto H, Fujita N, Hamamatsu K, Murakami T, Nakamoto Y, Saga T, Ishimori T, Shimizu Y, Watanabe H, Sano K, Harada N, Nakamura H, Toyoda K, Kimura H, Nakagawa S, Hirai M, Murakami A, Ono M, Togashi K, Saji H, Inagaki N.
              \nFirst-In-Human Evaluation of Positron Emission Tomography\/Computed Tomography with [18<\/sup>F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas<\/span>
              \n<\/span>Front. Endocrinol.<\/em>\u00a012, 717101 (2021)<\/span><\/span><\/li>\n
            6. Nakashima K, Iikuni S, Watanabe H, Ono M.
              \nDevelopment of a novel radiotheranostic platform with a DOTA-based trifunctional chelating agent<\/span>
              \n<\/span>Chem. Commun.<\/em>\u00a057 6432-6435 (2021)<\/span><\/span><\/li>\n
            7. Watanabe H, Idoko Y, Iikuni S, Ide T, Shimizu Y, Nakamoto Y, Ono M.
              \nSynthesis and biological evaluation of novel 18<\/sup>F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain<\/span>
              \n<\/span>Bioorg. Med. Chem. Lett.<\/em> 43 128098 (2021)<\/span><\/span><\/li>\n
            8. Watanabe H, Kishimoto T, Kaide S, Tarumizu Y, Tatsumi H, Iikuni S, Ono M.
              \nCharacterization and Optimization of Radioiodinated Benzimidazopyrimidine and Pyridoimidazopyridine Derivatives for Development of Tau Imaging Probes<\/span>
              \n<\/span>ACS Med. Chem. Lett.<\/em> 12(5) 805-811 (2021)<\/span><\/span><\/li>\n
            9. Iikuni S, Okada Y, Shimizu Y, Watanabe H, Ono M.
              \nModulation of pharmacokinetics of radioligand targeting carbonic anhydrase-IX utilizing albumin-binding moiety<\/span>
              \n<\/span>Mol. Pharm.<\/em>\u00a018(3) 966-975 (2021)<\/span><\/span><\/li>\n
            10. Shimizu Y, Nakai Y, Watanabe H, Iikuni S, Ono M, Saji H, Kuge Y, Saga T, Nakamoto Y.
              \nIncreased [18<\/sup>F]FMISO accumulation under hypoxia by multi-drug resistant protein 1 inhibitors<\/span>
              \n<\/span>EJNMMI res.<\/em>\u00a011 9 (2021)<\/span><\/span><\/li>\n
            11. Watanabe H, Tarumizu Y, Kaide S, Shimizu Y, Iikuni S, Nakamoto Y, Ono M.
              \nStructure-Activity and Brain Kinetics Relationships of 18<\/sup>F Labeled Benzimidazopyridine Derivatives as Tau PET Tracers<\/span>
              \n<\/span>ACS Med. Chem. Lett.<\/em>\u00a012(2) 262-266 (2021)<\/span><\/span><\/li>\n
            12. Shimizu Y, Nakai Y, Iikuni S, Watanabe H, Nakamoto Y, Ono M.
              \nSynthesis and Evaluation of Gallium-68-labeled Nitroimidazole Based Imaging Probes for PET Diagnosis of Tumor Hypoxia<\/span>
              \n<\/span>Ann. Nucl. Med.<\/em>\u00a035(3) 360-369 (2021)<\/span><\/span><\/li>\n
            13. Nakashima K, Iikuni S, Okada Y, Watanabe H, Shimizu Y, Nakamoto Y, Ono M.
              \nEvaluation of 68<\/sup>Ga-labeled Imidazothiadiazole Sulfonamide Derivatives for PET Imaging of Carbonic Anhydrase-IX<\/span>
              \n<\/span>Nucl. Med. Biol.<\/em> 93, 46-53 (2021)<\/span><\/span><\/li>\n<\/ol>\n

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              2020<\/h2>\n
                \n
              1. Iikuni S, Watanabe H, Shimizu Y, Nakamoto Y, Ono M.
                \nPET Imaging and Pharmacological Therapy Targeting Carbonic Anhydrase-IX High-expressing Tumors Using US2 Platform Based on Bivalent Ureidosulfonamide\u00a0<\/span>
                \n<\/span>PLoS One.<\/em>\u00a015(12) e0243327 (2020)<\/span><\/span><\/li>\n
              2. Kaide S, Watanabe H, Shimizu Y, Iikuni S, Nakamoto Y, Hasegawa M, Itoh K, Ono M.<\/span>
                \nIdentification and Evaluation of Bisquinoline Scaffold as a New Candidate for \u03b1-Synuclein-PET Imaging<\/span>
                \nACS Chem. Neurosci. 11(24) 4254-4261 (2020)<\/span><\/em><\/li>\n
              3. Watanabe H, Kawano K, Iikuni S, Shimizu Y, Ono M.
                \nNovel radiogallium-labeled pyridyl benzofuran derivative for detection of amylin aggregates in\u00a0 pancreas<\/span>
                \n<\/span>Nucl. Med. Biol.<\/em>\u00a090-91 93-97 (2020)<\/span><\/span><\/li>\n
              4. Ubukata S, Oishi N, Higashi T, Kagawa S, Yamauchi H, Okuyama C, Watanabe H, Ono M, Saji H,\u00a0 Aso T, Murai T, Ueda K.
                \nSpatial patterns of amyloid deposition in patients with chronic focal or diffuse traumatic brain injury using 18<\/sup>F-FPYBF-2 PET<\/span>
                \nNeuropsychiatr. Dis. Treat.<\/span><\/span><\/em>\u00a016 2719-2732 (2020)<\/span><\/span><\/li>\n
              5. Iikuni S, Kitano A, Watanabe H, Shimizu Y, Ono M.
                \nSynthesis and Evaluation of Novel Technetium-99m-hydroxamamide Complex Based on Imidazothiadiazole Sulfonamide Targeting Carbonic Anhydrase-IX for Tumor Imaging<\/span>
                \nBioorg. Med. Chem. Lett.<\/em>\u00a030(22) 127596 (2020)<\/span><\/span><\/li>\n
              6. Watanabe H, Sakai S, Iikuni S, Shimizu Y, Shirakawa H, Kaneko S, Ono M.
                \nSynthesis and Biological Evaluation of Radioiodinated 3-Phenylcoumarin Derivatives Targeting Myelin in Multiple Sclerosis<\/span>
                \nBioorg. Med. Chem. Lett.<\/em>\u00a030(24) 127562 (2020)<\/span><\/span><\/li>\n
              7. Fuchigami T, Kawasaki M, Watanabe H, Nakagaki T, Nishi K, Sano K, Atarashi R, Nakaie M, Yoshida S, Ono M, Nishida N, Nakayama M.
                \nFeasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain
                \n<\/span>Nucl. Med. Biol.<\/em>\u00a090-91, 41-48 (2020)<\/span><\/span><\/li>\n
              8. Ding N, Sano K, Kanazaki K, Shimizu Y, Watanabe H, Namita T, Shiina T, Ono M, Saji H.
                \nDevelopment of Gold Nanorods Conjugated with Radiolabeled Anti-human Epidermal Growth Factor Receptor 2 (HER2) Monoclonal Antibody as Single-photon Emission Computed Tomography\/Photoacoustic Dual-imaging Probes Targeting HER2-positive Tumors<\/span>
                \nBiol. Pharm. Bull.<\/em>\u00a043(12) 1859-1866 (2020)<\/span><\/span><\/li>\n
              9. Ding N, Sano K, Kanazaki K, Shimizu Y, Watanabe H, Namita T, Shiina T, Ono M, Saji H.
                \nSensitive Photoacoustic\/Magnetic Resonance Dual Imaging Probe for Detection of Malignant Tumors<\/span>
                \nJ. Pharm. Sci.<\/em>\u00a0109(10) 3153-3159 (2020)<\/span><\/span><\/li>\n
              10. Iikuni S, Okada Y, Shimizu Y,\u00a0 Watanabe H, Ono M.
                \nSynthesis and Evaluation of Indium-111-labeled Imidazothiadiazole Sulfonamide Derivative for Single Photon Emission Computed Tomography Imaging Targeting Carbonic Anhydrase-IX<\/span>
                \nBioorg. Med. Chem. Lett.<\/em>\u00a030(14) 127255 (2020)<\/span><\/span><\/li>\n
              11. Ikeda H, Ishii A, Sano K, Chihara H, Arai D, Abekura Y, Nishi H, Ono M, Saji H, Miyamoto S.
                \nActivatable fluorescence imaging of macrophages in cerebral aneurysms using iron oxide nanoparticles conjugated with indocyanine green<\/span>
                \nFront. Neurosci. <\/em>14 370 (2020)<\/span><\/li>\n
              12. Watanabe H, Kawano K, Shimizu Y, Iikuni S, Nakamoto Y, Togashi K, Ono M.
                \nDevelopment of Novel PET Imaging Probes for Detection of Amylin Aggregates in the Pancreas<\/span>
                \nMol. Pharm.\u00a0<\/em>17(4) 1293-1299 (2020)<\/span><\/li>\n
              13. Watanabe H, Tatsumi H, Kaide S, Shimizu Y, Iikuni S, Ono M.
                \nStructure-activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes<\/span>
                \nACS Med. Chem. Lett. <\/em>11(2) 120-126 (2020)<\/span><\/li>\n
              14. Kawai R, Chiba S, Okuwaki K, Kanada R, Doi H, Ono M, Mochizuki Y, Okuno Y.
                \nStabilization Mechanism for a Non-fibrillar Amyloid \u03b2 Oligomer Based on Formation of a Hydrophobic Core Determined by Dissipative Particle Dynamics<\/span>
                \nACS Chem. Neurosci.\u00a0<\/em>11(3) 385-394 (2020)<\/span><\/li>\n<\/ol>\n

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                2019<\/h2>\n
                  \n
                1. Watanabe H, Matsushita N, Shimizu Y, Iikuni S, Nakamoto Y, Togashi K, Ono M.
                  \n<\/span><\/span><\/span><\/span><\/span>Synthesis and characterization of a novel 18<\/sup>F-labeled 2,5-diarylnicotinamide derivative targeting orexin 2 receptor<\/span><\/span><\/span><\/span><\/span>
                  \nMed. Chem. Commun. <\/span><\/span><\/em>10(12) 2126-2130<\/span><\/span><\/li>\n
                2. Watanabe H, Itagaki F, Shimizu Y, Iikuni S, Ono M.
                  \n<\/span><\/span><\/span><\/span><\/span>Synthesis and evaluation of a radioiodinated BODIPY derivative as a thiol labeling agent<\/span><\/span><\/span><\/span><\/span>
                  \nJ. Label. Compd. Radiopharm. <\/span><\/span><\/em>62(13) 885-891 (2019)<\/span><\/span><\/li>\n
                3. Yagi Y, Kimura H, Okuda H, Ono M, Nakamoto Y, Togashi K, Saji H.
                  \n<\/span><\/span><\/span><\/span><\/span>Evaluation of [18<\/sup>F]pitavastatin as a positron emission tomography tracer for in vivo organic transporter polypeptide function<\/span><\/span><\/span><\/span><\/span>
                  \nNucl. Med. Biol. <\/span><\/span><\/em>74-75<\/span><\/span>\u00a025-31 (2019)<\/span><\/span><\/li>\n
                4. Mori D, Kimura H, Kawashima H, Yagi Y, Arimitsu K, Ono M, Saji H.<\/span>
                  \n<\/span><\/span><\/span><\/span>Development of 99m<\/sup>Tc Radiolabeled A85380 Derivatives Targeting Cerebral Nicotinic Acetylcholine Receptor: Novel Radiopharmaceutical Ligand 99m<\/sup>Tc-A-YN-IDA-C4<\/span><\/span><\/span><\/span><\/span>
                  \nBioorg. Med. Chem. <\/span><\/span><\/em>27(18) 4200-4210 (2019)<\/span><\/span><\/li>\n
                5. Kaide S, Watanabe H, Shimizu Y, Tatsumi H, Iikuni S,\u00a0 Nakamoto Y, Togashi K, Ihara M, Saji H, Ono M.<\/span><\/span><\/span><\/span>
                  \n18<\/span><\/sup>F-Labeled Benzimidazopyridine Derivatives for PET Imaging of Tau Pathology in Alzheimer\u2019s Disease<\/span><\/span><\/span><\/span>
                  \nBioorg. Med. Chem. <\/span><\/span><\/em>27(16) 3587-3594 (2019)<\/span><\/span><\/li>\n
                6. Shimizu Y, Tanimura K, Iikuni S, Watanabe H, Saji H, Ono M.
                  \n<\/span><\/span><\/span><\/span>Development of technetium-99m-labeled BODIPY-based probes targeting lipid droplets for diagnosis of hyperlipidemia-related diseases<\/span><\/span><\/span><\/span>
                  \nMolecules<\/em>\u00a024(12) 2283 (2019)<\/span><\/span><\/li>\n
                7. Watanabe H, Miki Y, Shimizu Y, Saji H, Ono M.<\/span><\/span><\/span><\/span>
                  \n<\/span><\/span><\/span>Synthesis and evaluation of novel two-photon fluorescence probes for in vivo imaging of amylin aggregates in the pancreas<\/span><\/span><\/span><\/span>
                  \nDyes. Pigm. <\/span><\/span><\/em>170 107615 (2019)<\/span><\/span><\/span><\/li>\n
                8. Kimura H, Yagi Y, Mikamo M, Maeda K, Kagawa S, Arimitsu K, Higashi T, Nishii R, Ono M, Nakamoto Y, Togashi K, Kusuhara H, Saji H.<\/span><\/span><\/span><\/span>
                  \n<\/span><\/span><\/span>Evaluation of Transporter-Mediated Hepatobiliary Transport of Newly Developed 18<\/sup>F-labeled Pitavastatin Derivative, PTV-F1, in Rats by PET Imaging<\/span><\/span><\/span><\/span>
                  \nDrug Metab. Pharmacokinet.<\/em>\u00a034(5), 317-324 (2019)<\/li>\n
                9. Watanabe H, Fukui K, Shimizu Y, Idoko Y, Nakamoto Y, Togashi K, Saji H, Ono M.<\/span><\/span><\/span><\/span>
                  \n<\/span><\/span><\/span>Synthesis and biological evaluation of F-18 labeled tetrahydroisoquinoline derivatives targeting orexin 1 receptor<\/span><\/span><\/span><\/span>
                  \nBioorg. Med. Chem. Lett.<\/em> 29(13) 1620-1623 (2019)<\/span><\/li>\n
                10. Fuchigami T, Kawasaki M, Koyama R, Nakaie M, Nakagaki T, Sano K, Atarashi R, Yoshida S, Haratake M, Ono M, Nishida N, Nakayama M.<\/span><\/span><\/span><\/span>
                  \n<\/span><\/span><\/span>Development of radioiodinated benzofuran derivatives for in vivo imaging of prion deposits in the brain<\/span><\/span><\/span><\/span>
                  \nACS Infect. Dis. <\/i>5(12) 2003-2013<\/li>\n
                11. Iikuni S, Tanimura K, Watanabe H, Shimizu Y, Saji H, Ono M.<\/span><\/span><\/span><\/span>
                  \n<\/span><\/span><\/span>Development of 99m<\/sup>Tc-Hydroxamamide Complex as Probe Targeting Carbonic Anhydrase IX<\/span><\/span><\/span><\/span>
                  \nMol. Pharm. <\/em>16(4) 1489-1497 (2019)<\/li>\n
                12. Yamauchi H, Kagawa S, Takahashi M, Oishi N, Ono M, Higashi T.<\/span><\/span><\/span><\/span>
                  \n<\/span><\/span><\/span>Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease<\/span><\/span><\/span><\/span>
                  \nNeuroimage: Clinical<\/em>\u00a022 101762<\/span> (2019)<\/li>\n
                13. Saga T, Nakamoto Y, Ishimori T, Inoue T, Shimizu Y, Kimura H, Akamatsu S, Goto T, Watanabe H, Kitaguchi K, Watanabe M, Ono M, Saji H, Ogawa O, Togashi K.<\/span><\/span><\/span><\/span>
                  \n<\/span><\/span><\/span>Initial evaluation of PET\/CT with 18<\/sup>F-FSU-880 targeting prostate-specific membrane antigen in prostate cancer patients<\/span><\/span><\/span><\/span>
                  \nCancer Sci. <\/span><\/em>110(2) 742-750<\/span>\u00a0(2019)<\/li>\n<\/ol>\n

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                  2018<\/h2>\n
                    \n
                  1. Watanabe H, Yoshimura M, Sano K, Shimizu Y, Kaide S, Nakamoto Y, Togashi K, Ono M, Saji H.<\/span><\/span><\/span>
                    \n<\/span><\/span><\/span>Characterization of Novel 18<\/sup>F-Labeled Phenoxymethylpyridine Derivatives as Amylin Imaging Probes<\/span><\/span><\/span>
                    \nMol. Pharm.<\/em>\u00a015(12) 5574-5584 (2018)<\/li>\n
                  2. Watanabe H, Saji H, Ono M.<\/span><\/span><\/span>
                    \n<\/span><\/span><\/span>Novel Fluorescence Probes based on the Chalcone Scaffold for In vitro Staining of \u03b2-Amyloid Plaques<\/span><\/span><\/span>
                    \nBioorg. Med. Chem. Lett.<\/em>\u00a028(19) 3242-3246 (2018)<\/li>\n
                  3. Sano K, Kanada Y, Takahashi K, Ding N, Kanazaki K, Mukai T, Ono M, Saji H.<\/span><\/span><\/span>
                    \n<\/span><\/span><\/span>Enhanced Delivery of Radiolabeled Polyoxazoline into Tumors via Self-Aggregation Under Hyperthermic Conditions<\/span><\/span><\/span>
                    \nMol. Pharm.<\/em>\u00a015(9) 3997-4003 (2018)<\/li>\n
                  4. Kimura H, Yamauchi S, Kawashima H, Arimitsu K, Yagi Y, Nakamoto Y, Togashi K, Ono M, Saji H.
                    \n<\/span><\/span><\/span>Synthesis and evaluation of a [18<\/sup>F]formyl-Met-Leu-Phe derivative: A positron emission tomography imaging probe for bacterial infections<\/span><\/span><\/span>
                    \nBioorg. Med. Chem. Lett.<\/em> 28(17) 2949-2952 (2018)<\/li>\n
                  5. Kaide S, Ono M, Watanabe H, Shimizu Y, Nakamoto Y, Togashi K, Yamaguchi A, Hanaoka H, Saji H.<\/span><\/span><\/span>
                    \nConversion of Iodine to Fluorine-18 Based on Iodinated Chalcone and Evaluation for \u03b2-Amyloid PET Imaging<\/span><\/span><\/span>
                    \nBioorg. Med. Chem.<\/em>\u00a026(12) 3352-3358 (2018)<\/li>\n
                  6. Ikeda H, Ishii A, Sano K, Chihara H, Arai D, Abekura Y, Nishi H, Ono M, Saji H, Miyamoto S.<\/span><\/span><\/span>
                    \nActivatable fluorescence imaging of macrophages in atherosclerotic plaques using iron oxide nanoparticles conjugated with indocyanine green<\/span><\/span><\/span>
                    \nAtherosclerosis<\/span>\u00a0<\/span><\/em>275<\/span>\u00a01-10\u00a0(2018)<\/li>\n
                  7. Iikuni S, Ono M, Watanabe H, Shimizu Y, Sano K, Saji H.<\/span><\/span><\/span>
                    \nCancer radiotheranostics targeting carbonic anhydrase-IX with 111<\/sup>In- and 90<\/sup>Y-labeled ureidosulfonamide scaffold for SPECT imaging and radionuclide-based therapy<\/span><\/span><\/span>
                    \nTheranostics<\/em><\/span>\u00a08(11) 2992-3006\u00a0(2018)<\/li>\n
                  8. Temma T, Kondo N, Yoda K, Nishigori K, Onoe S, Shiomi M, Ono M, Saji H.<\/span><\/span><\/span>
                    \nComparison of 125<\/sup>I- and 111<\/sup>In-labeled peptide probes for in vivo detection of oxidized low density lipoprotein in atherosclerotic plaques<\/span><\/span><\/span>
                    \nAnn. Nucl. Med.<\/em>\u00a032(6) 410-416 (2018)<\/li>\n
                  9. Kaide S, Ono M, Watanabe H, Kitada A, Yoshimura M, Shimizu Y, Ihara M, Saji H.<\/span><\/span>
                    \nStructure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology<\/span><\/span>
                    \nACS Med. Chem. Lett.<\/em>\u00a09(5) 478-483\u00a0(2018)<\/li>\n
                  10. Matsuoka D, Watanabe H, Shimizu Y, Kimura H, Yagi Y, Kawai R, Ono M, Saji H.<\/span><\/span>
                    \nStructure\u2013activity relationships of succinimidyl-Cys-C(O)-Glu derivatives with different near-infrared fluorophores as optical imaging probes for prostate-specific membrane antigen<\/span><\/span>
                    \nBioorg. Med. Chem.<\/em>\u00a026(9) 2291-2301\u00a0(2018)<\/li>\n
                  11. Nishii R, Higashi T, Kagawa S, Okuyama C, Kishibe Y, Takahashi M, Okina T, Suzuki N, Hasegawa H, Nagahama Y, Ishizu K, Oishi N, Kimura H, Watanabe H, Ono M, Saji H, Yamauchi H.<\/span><\/span>
                    \n18<\/sup>F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer – Biodistribution and radiation dosimetry assessment of first-in-man 18<\/sup>F-FPYBF-2 PET imaging –<\/span><\/span>
                    \nAnn. Nucl. Med.<\/em>\u00a032(4) 256-263\u00a0(2018)<\/li>\n
                  12. Higashi T, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Okina T, Suzuki N, Hasegawa H, Nagahama Y, Ishizu K, Oishi N, Kimura H, Watanabe H, Ono M, Saji H, Yamauchi H.<\/span><\/span>
                    \n18<\/sup>F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer\u00a0 \u2013 First experience in 61 volunteers and 55 patients with dementia \u2013<\/span><\/span>
                    \nAnn. Nucl. Med.<\/em>\u00a032(3) 206-216 (2018)<\/li>\n
                  13. Makino A, Miyazaki A, Tomoike A, Kimura H, Arimitsu K, Hirata M, Ohmomo Y, Nishii R, Okazawa H, Kiyono Y, Ono M, Saji H.<\/span><\/span>
                    \nPET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy<\/span><\/span>
                    \nBioorg. Med. Chem.<\/em>\u00a026(8) 1609-1613 (2018)<\/li>\n
                  14. Kawai R, Araki M, Yoshimura M, Kamiya N, Ono M, Saji H, Okuno Y.<\/span><\/span>
                    \nCore Binding Site of a Thioflavin-T-derived Imaging Probe on Amyloid \u03b2 Fibrils Predicted by Computational Methods<\/span><\/span>
                    \nACS Chem. Neurosci.<\/em>\u00a09(5) 957-966 (2018)<\/li>\n
                  15. Abe J, Isobe N, Mikata K, Nagahori H, Naito Y, Saji H, Ono M, Kawamura S.<\/span><\/span>
                    \nFlumioxazin metabolism in pregnant animals and cell-based protoporphyrinogen IX oxidase (PPO) inhibition assay of fetal metabolites in various animal species to elucidate the mechanism of the rat-specific developmental toxicity<\/span><\/span>
                    \nToxicol. Appl. Pharmacol.<\/span><\/em> 339 34-41<\/span>(2018)<\/li>\n
                  16. Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M.<\/span><\/span>
                    \nConstruction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice<\/span><\/span>
                    \nJ. Drug. Target.<\/em>\u00a026(4) 373-381 (2018)<\/li>\n
                  17. Kimura H, Ogawa Y, Fujimoto H, Mukai E, Kawashima H,\u00a0Arimitsu K, Toyoda K, Fujita N, Yagi Y, Hamamatsu K, Murakami T, Murakami A, Ono M, Nakamoto Y, Togashi K, Inagaki N, Saji H.<\/span><\/span>
                    \nEvaluation of 18<\/sup>F-Labeled Exendin(9-39) Derivatives Targeting Glucagon-like Peptide-1 Receptor for Pancreatic \u03b2-cell Imaging<\/span><\/span>
                    \nBioorg. Med. Chem.<\/em> 26(2) 463-469 (2018)<\/li>\n<\/ol>\n

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                    2017<\/h2>\n
                      \n
                    1. Watanabe H, Ariyoshi T, Ozaki A, Ihara M, Ono M, Saji H.<\/span><\/span>
                      \nSynthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging \u03b1-synuclein aggregates<\/span><\/span>
                      \nBioorg. Med. Chem.<\/em>\u00a025(24) 6398-6403 (2017)<\/li>\n
                    2. Saji H.<\/span>
                      \nIn Vivo Molecular Imaging<\/span><\/span>
                      \nBiol. Pham. Bull<\/em>. 40(10), 1605-1615\u00a0<\/span>(2017)\u00a0Review<\/em>.<\/li>\n
                    3. Matsuoka D, Watanabe H, Shimizu Y, Kimura H, Ono M, Saji H.<\/span>
                      \nSynthesis and evaluation of a novel near-infrared fluorescent probe based on succinimidyl-Cys-C(O)-Glu that targets prostate-specific membrane antigen for optical imaging<\/span>
                      \nBioorg. Med. Chem. Lett.<\/em>\u00a027(21) 4876-4880 (2017)<\/li>\n
                    4. Watanabe H.
                      \nDevelopment of SPECT probes for in vivo imaging of \u03b2-amyloid and tau aggregates in the Alzheimer\u2019s disease brain<\/span>
                      \nYAKUGAKU ZASSHI <\/em>137(11), 1361-1365 (2017)\u00a0Review<\/em>.<\/li>\n
                    5. Kimura H, Fujita N, Kanbe K, Matsuda H, Watanabe H, Arimitsu K, Fujimoto H, Hamamatsu K, Yagi Y, Ono M, Inagaki N, Saji H.<\/span>
                      \nSynthesis and Biological Evaluation of an 111<\/sup>In-Labeled Exendin-4 Derivative as a SPECT probe for Imaging of Pancreatic \u03b2-cells<\/span>
                      \nBioorg. Med. Chem.<\/em>\u00a025(20), 5772-5778 (2017)<\/li>\n
                    6. Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y.<\/span><\/span>
                      \nAccelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells<\/span>
                      \nCancer Sci.<\/em>\u00a0108(9), 1803-1810<\/span><\/span>\u00a0(2017)<\/li>\n
                    7. Watanabe H, Ono M, Ariyoshi T, Katayanagi R, Saji H.<\/span><\/span>
                      \nNovel benzothiazole derivatives as fluorescent probes for detection of \u03b2-amyloid and \u03b1-synuclein aggregates<\/span>
                      \nACS Chem. Neurosci.<\/em>\u00a08(8) 1656-1662 (2017)<\/span><\/span><\/li>\n
                    8. Ono M, Watanabe H, Ikehata Y, Ding N, Yoshimura M, Sano K, Saji H.<\/span>
                      \nRadioiodination of BODIPY and Its Application to a Nuclear and Optical Dual Functional Labeling Agent for Proteins and Peptides<\/span>
                      \nSci. Rep.<\/em>\u00a07 3337 (2017)<\/span><\/span><\/li>\n
                    9. Sano K, Kanada Y, Kanazaki K, Ding N, Ono M, Saji H.<\/span>
                      \nBrachytherapy with Intratumoral Injections of Radiometal-labeled Polymers that Thermo-responsively Self-aggregate in Tumor Tissues<\/span><\/span>
                      \n J. Nucl. Med.<\/span><\/em>\u00a058(9) 1380-1385 (2017)<\/span><\/li>\n
                    10. Iikuni S, Ono M, Tanimura K, Watanabe H, Yoshimura M, Saji H.<\/span>
                      \nSynthesis and Biological Evaluation of Novel Technetium-99m-Labeled Phenylquinoxaline Derivatives as Single Photon Emission Computed Tomography Imaging Probes Targeting \u03b2-Amyloid Plaques in Alzheimer\u2019s Disease<\/span><\/span>
                      \n RSC Adv.<\/span><\/em>\u00a07(33) 20582-20590\u00a0(2017)<\/span><\/span><\/li>\n
                    11. Kimura H, Okuda H, Ishiguro M, Arimitsu K, Makino A, Nishii R, Miyazaki A, Yagi Y, Watanabe H, Kawasaki I, Ono M, Saji H.<\/span>
                      \n18<\/sup>F-Labeled pyrido[3,4-d]pyrimidine as an effective probe for imaging of L858R-mutant epidermal growth factor receptor<\/span><\/span>
                      \n ACS Med. Chem. Lett.<\/span><\/em>\u00a08(4) 418-422\u00a0(2017)<\/span><\/span><\/li>\n
                    12. Hagimori M, Hatabe E, Sano K, Miyazaki H, Sasaki H, Saji H, Mukai T.<\/span>
                      \nAn activatable fluorescent \u03b3-polyglutamic acid complex for sentinel lymph node imaging<\/span><\/span>
                      \n Biol. Pharm. Bull.<\/span><\/em>\u00a040(3) 297-302\u00a0(2017)<\/span><\/span><\/li>\n
                    13. Suzuki S, Furuki T, Watanabe H, Ono M, Saji H.<\/span>
                      \nInvestigating Tumor Accumulation of Nanoparticles Using Fluorescently Labeled Lactosomes<\/span><\/span>
                      \n ELCAS J.<\/span><\/em>\u00a02 43-47\u00a0(2017)<\/span><\/span><\/li>\n
                    14. Sano K, Ohashi M, Kanazaki K, Makino A, Ding N, Deguchi J, Kanada Y, Ono M, Saji H.<\/span>
                      \nIndocyanine green-labeled polysarcosine for in vivo photoacoustic tumor imaging<\/span><\/span>
                      \n Bioconjugate Chem.<\/span><\/em>\u00a028(4) 1024-1030\u00a0(2017)<\/span><\/span><\/li>\n
                    15. Kimura H, Matsuda H, Ogawa Y, Fujimoto H, Toyoda K, Fujita N, Arimitsu K, Hamamatsu K, Yagi Y, Ono M, Inagaki N, Saji H.<\/span>
                      \nDevelopment of 111<\/sup>In-labeled Exendin(9-39) Derivatives for Single-Photon Emission Computed Tomography Imaging of Insulinoma<\/span><\/span>
                      \n Bioorg. Med. Chem.<\/span><\/em>\u00a025(4) 1406-1412 (2017)<\/span>
                      \n<\/span><\/span><\/li>\n
                    16. Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y.<\/span>
                      \nRole of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages<\/span><\/span>
                      \n J. Pharm. Sci.<\/em>\u00a0106(<\/span>1) 168-175 (2017)<\/li>\n<\/ol>\n

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                      2016<\/h2>\n
                        \n
                      1. Iikuni S, Ono M, Watanabe H, Yoshimura M, Ishibashi-Ueda H, Ihara M, Saji H.<\/span><\/span>
                        \nNovel Bivalent\u00a099m<\/sup>Tc-Complex with N-Methyl-Substituted Hydroxamamide as Probe for Imaging of Cerebral Amyloid Angiopathy<\/span><\/span>
                        \nPLoS ONE<\/span><\/em>,\u00a0<\/span>11(9) e0163969 (2016)<\/li>\n
                      2. Ono M, Watanabe H, Kitada A, Matsumura K, Ihara M, Saji H.<\/span><\/span>
                        \nHighly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer\u2019s Disease<\/span><\/span>
                        \nSci. Rep.<\/em>\u00a06 34197 (2016)<\/span>
                        \n<\/span><\/li>\n
                      3. Kimura H, Yagi Y, Arimitsu K, Maeda K, Ikejiri K, Takano J, Kusuhara H, Kagawa S, Ono M, Sugiyama Y, Saji H.<\/span><\/span>
                        \nRadiosynthesis of Novel Pitavastatin Derivative ([18<\/sup>F]PTV-F1) as a Tracer for hepatic OATP Using a One-Pot Synthetic Procedure<\/span><\/span>
                        \nJ. Labelled Compd. Radiopharm.<\/em>\u00a059(13) 565-575 (2016)<\/span><\/li>\n
                      4. Kanazaki K, Sano K, Makino A, Homma T, Ono M, Saji H.<\/span>
                        \nPolyoxazoline multivalently conjugated with indocyanine green for sensitive in vivo photoacoustic imaging of tumors<\/span><\/span>
                        \nSci. Rep<\/em>.\u00a0<\/span>6 33798 (2016)<\/li>\n
                      5. Kimura H, Tomatsu K, Saiki H, Arimitsu K, Ono M, Kawashima H, Iwata R, Nakanishi H, Ozeki E, Kuge Y, Saji H.<\/span>
                        \nContinuous-flow synthesis of\u00a0N<\/em>-succinimidyl 4-[18<\/sup>F]fluorobenzoate using a single microfluidic chip<\/span>
                        \nPLoS ONE\u00a0<\/em><\/span>11(7) e0159303 (2016)<\/span><\/span><\/li>\n
                      6. Harada N, Kimura H, Onoe S, Watanabe H, Matsuoka D, Arimitsu K, Ono M, Saji H.<\/span>
                        \nSynthesis and Biological Evaluation of Novel\u00a018<\/sup>F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for Positron Emission Tomography of Prostate Cancer<\/span>
                        \nJ. Nucl. Med.<\/em><\/span>\u00a0<\/em>57(12) 1978-1984 (2016)<\/span><\/span><\/li>\n
                      7. Ding N, Sano K, Kanazaki K, Ohashi M, Deguchi J, Kanada Y, Ono M, Saji H.<\/span>
                        \nIn vivo HER2-Targeted Magnetic Resonance Tumor Imaging Using Iron Oxide Nanoparticles Conjugated with Anti-HER2 Fragment Antibody<\/span>
                        \nMol. Imaging Biol.\u00a0<\/em><\/span><\/span>18(6) 870-876 (2016)<\/li>\n
                      8. Yoshimura M, Ono M, Watanabe H, Kimura H, Saji H.<\/span>
                        \nDevelopment of\u00a099m<\/sup>Tc-labeled Pyridyl Benzofuran Derivatives to Detect Pancreatic Amylin in Islet Amyloid Model Mice<\/span>
                        \nBioconjugate Chem.\u00a0<\/em>27(6) 1532-1539 (2016)<\/span><\/span><\/li>\n
                      9. Watanabe H, Kawasaki A, Sano K, Ono M, Saji H.<\/span>
                        \nSynthesis and evaluation of copper-64 labeled benzofuran derivatives targeting \u03b2-amyloid aggregates<\/span>
                        \nBioorg. Med. Chem.\u00a0<\/em>24(16) 3618-3623 (2016)<\/span>
                        \n<\/span><\/span><\/li>\n
                      10. Kurihara K, Ueda M, Hara I, Hara E, Sano K, Makino A, Ozeki E, Yamamoto F, Saji H, Togashi K, Kimura S.<\/span>
                        \nInflammation-induced synergetic enhancement of nanoparticle treatments with DOXIL\u00ae and\u00a090<\/sup>Y-Lactosome for orthotopic mammary tumor<\/span>
                        \nJ. Nanopart. Res.\u00a0<\/em>18 137 (2016)<\/span>
                        \n<\/span><\/span><\/li>\n
                      11. Nakamoto Y, Ishimori T, Sano K, Temma T, Ueda M, Saji H, Togashi K.<\/span>
                        \nClinical efficacy of dual-phase scanning using\u00a068<\/sup>Ga-DOTATOC-PET\/CT in the detection of neuroendocrine tumours<\/span>
                        \nClin. Radiol.\u00a0<\/em><\/span>71 1069.e1-1069.e5 (2016)<\/span><\/li>\n
                      12. Iikuni S, Ono M, Watanabe H, Matsumura K, Yoshimura M, Kimura H, Ishibashi-Ueda H, Okamoto Y, Ihara M, Saji H.
                        \n<\/span>Imaging of Cerebral Amyloid Angiopathy with Bivalent\u00a099m<\/sup>Tc-Hydroxamamide Complexes<\/span>
                        \nSci. Rep.<\/span>\u00a0<\/em>6 25990 (2016)<\/span><\/li>\n
                      13. Ono M, Doi Y, Watanabe H, Ihara M, Ozaki A, Saji H.
                        \n<\/span>Structure-Activity Relationships of Radioiodinated Diphenyl Derivatives with Different Conjugated Double Bonds as Ligands for \u03b1-Synuclein Aggregates<\/span>
                        \nRSC Adv.<\/span>\u00a0<\/em>6(50) 44305-44312 (2016)<\/span><\/li>\n
                      14. Ono M, Kitada A, Watanabe H, Miyazaki A, Kimura H, Saji H.
                        \n<\/span>Synthesis and Preliminary Characterization of Radioiodinated Benzofuran-3-yl-(indol-3-yl)maleimide Derivatives as Potential SPECT Imaging Probes for the Detection of Glycogen Synthase Kinase-3\u03b2 (GSK-3\u03b2) in the Brain<\/span>
                        \nJ. Labelled Comp. Radiopharm.<\/span>\u00a0<\/em>59(8) 317-321 (2016)<\/span><\/li>\n
                      15. Kimura H, Sampei S, Matsuoka D, Harada N, Watanabe H, Arimitsu K, Ono M, Saj H.
                        \n<\/span>Development of\u00a099m<\/sup>Tc-labeled Asymmetric Urea Derivatives that Target Prostate-Specific Membrane Antigen for Single-photon Emission Computed Tomography Imaging<\/span>
                        \nBioorg. Med. Chem.<\/span>\u00a0<\/em>24(10) 2251-2256 (2016)<\/span><\/li>\n
                      16. Matsuura Y, Ueda M, Higaki Y, Watanabe K, Habara S, Kamino S, Saji H, Enomoto S.
                        \n<\/span>Noninvasive evaluation of nicotinic acetylcholine receptor availability in mouse brain using single-photon emission computed tomography with [123<\/sup>I]5IA<\/span>
                        \nNucl. Med. Biol.<\/span>\u00a0<\/em>43(6) 372-378 (2016)<\/span><\/li>\n
                      17. Kanazaki K, Sano K, Makino A, Yamauchi F, Takahashi A, Homma T, Ono M, Saji H.
                        \n<\/span>Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging<\/span>
                        \nJ. Control. Release<\/span>\u00a0<\/em>226\u00a0115-123 (2016)<\/span><\/li>\n
                      18. Abe T, Naruse M, Young W. F., Kobashi N, Doi Y, Izawa A, Akama K, Okumura Y, Ikenaga M, Kimura H, Saji H, Mukai K, Matsumoto H.
                        \n<\/span>A novel CYP11B2-specific imaging agent for detection of unilateral subtypes of primary aldosteronism<\/span>
                        \nJ. Clin. Endocrinol. Metab.\u00a0<\/em>101(3) 1008-1015 (2016)<\/span><\/li>\n
                      19. Makino A, Arai T, Hirata M, Ono M, Ohmomo Y, Saji H.
                        \n<\/span>Development of novel PET probes targeting phosphatidylinositol 3-kinase (PI3K) in tumors<\/span>
                        \nNucl. Med. Biol.<\/em>\u00a043(1) 101-107 (2016)<\/span><\/li>\n<\/ol>\n

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                        <\/div>\n
                        <\/div>\n

                        2015<\/h2>\n
                          \n
                        1. Kondo N, Temma T, Deguchi J, Sano K, Ono M, Saji H.
                          \nDevelopment of PEGylated peptide probes conjugated with\u00a018<\/sup>F-labeled BODIPY for PET\/optical imaging of MT1-MMP activity<\/span>
                          \nJ. Control. Release\u00a0<\/em>220<\/strong>\u00a0476-483 (2015)<\/span><\/li>\n
                        2. Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M.
                          \nCharacterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits<\/span>
                          \nSci. Rep.\u00a0<\/em>5<\/strong>\u00a018440 (2015)<\/span><\/li>\n
                        3. Ueda<\/span>\u00a0M,\u00a0Yamagami D, Watanabe K, Mori A, Kimura H, Sano K, Saji H, Ishikawa K, Hori M, Sakakita H, Ikehara Y, Enomoto S.
                          \nHistological and Nuclear Medical Comparison of Inflammation After Hemostasis with Non-Thermal Plasma and Thermal Coagulation<\/span>
                          \nPlasma Process. Polym.\u00a0<\/em>12<\/strong>\u00a0(12) 1338-1342 (2015)<\/span><\/li>\n
                        4. Watanabe H, Ono M, Saji H.
                          \n<\/span>In Vivo Fluorescence Imaging of \u03b2-Amyloid Plaques with Push-Pull Dimethylaminothiophene Derivatives
                          \nChem. Commun.<\/em>\u00a051\u00a0<\/strong>(96) 17124-17127 (2015)<\/li>\n
                        5. Matsumura K, Ono M, Kitada A, Watanabe H, Yoshimura M, Iikuni S, Kimura H, Okamoto Y, Ihara M, Saji H.
                          \nStructure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents that Selectively Detect Neurofibrillary Tangles in Alzheimer\u2019s Disease Brains
                          \nJ. Med. Chem.<\/em>\u00a058\u00a0<\/strong>(18) 7241-7257 (2015)<\/li>\n
                        6. Onoe S, Temma T, Kanazaki K, Ono M, Saji H.
                          \n<\/span>Development of phtostabilized asymmetrical cyanine dyes for in vivo photoacoustic imaging of tumors
                          \nJ. Biomed. Opt.<\/em>\u00a0<\/em>20\u00a0<\/strong>(9) 096006 (2015)<\/li>\n
                        7. Kondo N, Temma T, Shimizu Y, Ono M, Saj H.
                          \n<\/span>Radioiodinated peptidic imaging probes for in vivo detection of Membrane Type-1 Matrix Metalloproteinase in cancers
                          \nBiol. Pharm. Bull.<\/em>\u00a038\u00a0<\/strong>(9) 1375-1382 (2015)<\/li>\n
                        8. Kanazaki K, Sano K, Makino A, Shimizu Y, Yamauchi F, Ogawa S, Ding N, Yano T, Temma T, Ono M, Saji H.
                          \n<\/span>Development of Anti-HER2 Fragment Antibody Conjugated to Iron Oxide Nanoparticles for in vivo HER2-Targeted Photoacoustic Tumor Imaging
                          \nNanomedicine: NBM\u00a0<\/em>11\u00a0<\/strong>(8) 2051-2060 (2015)<\/li>\n
                        9. Fuchigami T, Ogawa A, Yamashita Y, Haratake M, Watanabe H, Ono M, Kawasaki M, Yoshida S, Nakayama M.
                          \nDevelopment of alkoxy styrylchromone derivatives for imaging of cerebral amyloid-\u03b2 plaques with SPECT
                          \nBioorg. Med. Chem. Lett.<\/em>\u00a025<\/strong>\u00a0(16) 3363-3367 (2015)<\/li>\n
                        10. Sano K, Ohashi M, Kanazaki K, Ding N, Deguchi J, Kanada Y, Ono M, Saji H.
                          \n<\/span>In vivo photoacoustic imaging of cancer using indocyanine green-labeled monoclonal antibody targeting the epidermal growth factor receptor
                          \nBiochem. Biophys. Res. Commun<\/em>.\u00a0<\/em>464\u00a0<\/strong>(3) 820-825 (2015)<\/li>\n
                        11. Kawashima H, Kimura H, Nakaya Y, Tomatsu K, Arimitsu K, Nakanishi H, Ozeki E, Kuge Y, Saji H.
                          \n<\/span>Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[11<\/sup>C]methylation with [11<\/sup>C]CH3<\/sub>I: Rapid Synthesis of [11<\/sup>C]Raclopride
                          \nChem. Pharm. Bull.\u00a0<\/em>63<\/strong>\u00a0<\/strong>(9) 737-740 (2015)<\/li>\n
                        12. Saji H.<\/span>
                          \n<\/span>Application of Radioisotopes for Theranostics, a Combination of Diagnostics and Therapy
                          \nYAKUGAKU ZASSHI<\/em>\u00a0135\u00a0<\/strong>(4) 551-556 (2015)\u00a0Review<\/em>.<\/li>\n
                        13. Nakamoto Y, Sano K, Ishimori T, Ueda M, Temma T, Saji H, Togashi K.<\/span>
                          \nAdditional information gained by positron emission tomography with\u00a068<\/sup>Ga-DOTATOC for suspected unknown primary or recurrent neuroendocrine tumor<\/span>s
                          \nAnn. Nucl. Med.<\/em>\u00a029\u00a0<\/strong>(6) 512-518 (2015)<\/li>\n
                        14. Hagimori M, Temma T, Mizuyama N, Uto T, Yamaguchi Y, Tominaga Y, Mukai T, Saji H.
                          \nA high-affinity fluorescent Zn2+<\/sup>\u00a0sensor improved by the suppression of pyridine-pyridone tautomerism and its application in living cells
                          \n<\/span>Sens. Act. B.<\/em>\u00a0213<\/strong>\u00a045-52 (2015)<\/span><\/li>\n
                        15. Yagi Y, Kimura H, Arimitsu K, Ono M, Maeda K, Kusuhara H, Kajimoto T, Sugiyama Y, Saji H.
                          \nThe synthesis of [18<\/sup>F]pitavastatin as a tracer for hOATP using the Suzuki coupling
                          \nOrg. Biomol. Chem.<\/em>\u00a013<\/strong>\u00a01113-1121 (2015)<\/span><\/li>\n
                        16. Watanabe H, Ono M, Iikuni S, Kimura H, Okamoto Y, Ihara M, Saji H.
                          \nSynthesis and biological evaluation of\u00a0123<\/sup>I-labeled pyridyl benzoxazole derivatives: novel \u03b2-amyloid imaging probes for single-photon emission computed tomography<\/span>
                          \nRSC Adv.<\/em>\u00a05<\/strong>\u00a01009-1015 (2015)<\/li>\n
                        17. Temma T, Nishigori K, Onoe S, Sampei S, Kimura I, Ono M, Saji H.<\/span>
                          \nRadiofluorinated probe for PET imaging of fatty acid binding protein 4 in cancer<\/span>
                          \nNucl. Med. Biol.<\/em>\u00a042\u00a0<\/strong>(2) 184-191 (2015)<\/li>\n
                        18. Ono M, Saji H.
                          \nRecent Advances in Molecular Imaging Probes for \u03b2-Amyloid Plaques
                          \nMed. Chem. Commun.<\/em>\u00a06<\/b>\u00a0(3) 391-402 (2015)\u00a0Review<\/em>.<\/li>\n
                        19. Watanabe H, Ono M, Saji H.
                          \nNovel PET\/SPECT Probes for Imaging of Tau in Alzheimer\u2019s Disease<\/span>
                          \nScientificWorldJournal<\/em>\u00a02015<\/strong>\u00a0124192 (2015)\u00a0Review.<\/em><\/li>\n
                        20. Morishita M, Takahashi Y, Nishikawa M, Sano K, Kato K, Yamashita T, Imai T, Saji H, Takakura Y.
                          \nQuantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice.
                          \nJ. Pharm. Sci.<\/em>\u00a0104\u00a0<\/strong>(2) 705-713\u00a0(2015)<\/li>\n
                        21. Hagimori M, Mizuyama N, Tominaga Y,<\/span>\u00a0Mukai T, Saji H.
                          \nA low-molecular-weight fluorescent sensor with Zn2+<\/sup>\u00a0dependent bathochromic shift of emission wavelength and its imaging in living cells
                          \n<\/span>Dyes Pigm.<\/em>\u00a0113<\/strong>\u00a0205-209 (2015)<\/li>\n
                        22. Ueda<\/span>\u00a0M, Hisada H, Temma T, Shimizu Y, Kimura H, Ono M, Nakamoto Y, Togashi K,\u00a0Saji H.
                          \nGallium-68-labeled Anti-HER2 Single Chain Fv Fragment: Development and In Vivo Monitoring of HER2 Expression<\/span>
                          \nMol. Imaging Biol.\u00a0<\/em>17\u00a0<\/strong>(1) 102-110<\/span>\u00a0(2015)<\/li>\n<\/ol>\n

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                          2014<\/h2>\n
                            \n
                          1. Sozman, F., Kolemen, S., Kumada, H. O., Ono, M., Saji, H., Akkaya, E. U.
                            \nDesigning BODIPY-based probes for fluorescence imaging of \u03b2-amyloid plaques
                            \nRSC Adv.<\/em>,\u00a04<\/strong>\u00a0(92), 51032-51037. (2014)<\/li>\n
                          2. Watanabe, H., Ono, M., Iikuni, S., Yoshimura, M., Matsumura, K., Kimura, H., Saji, H.
                            \nA\u00a068<\/sup>Ga Complex Based on Benzofuran Scaffold for the Detection of \u03b2-Amyloid Plaques
                            \nBioorg. Med. Chem. Lett.<\/em>,\u00a024<\/strong>\u00a0(20), 4834-4837. (2014)<\/li>\n
                          3. Ueda, M., Saji,\u00a0H.
                            \nRadiolabeled Probes Targeting Hypoxia-Inducible Factor-1-Active Tumor Microenvironments<\/span>
                            \nScientificWorldJournal<\/em>,\u00a02014<\/strong>, 165461. (2014)\u00a0Review.<\/em><\/li>\n
                          4. Yoshimura, M., Ono, M., Watanabe, H., Kimura, H., Saji,\u00a0H.
                            \nFeasibility of Amylin Imaging in Pancreatic Islets with \u03b2-Amyloid Imaging Probes
                            \nSci. Rep.<\/em>,\u00a04<\/strong>, 6155. (2014)<\/li>\n
                          5. Temma, T., Onoe, S., Kanazaki, K., Ono, M., Saji, H.
                            \nPreclinical evaluation of a novel cyanine dye for tumor imaging with in vivo photoacoustic imaging
                            \nJ. Biomed. Opt.<\/em>,\u00a019<\/strong>\u00a0(9), 090501. (2014)<\/li>\n
                          6. Kanazaki, K., Sano, K., Makino, A., Takahashi, A., Deguchi, J., Ohashi, M., Temma, T., Ono, M., Saji,\u00a0H.
                            \nDevelopment of human serum albumin conjugated with NIR dye for photoacoustic tumor imaging
                            \nJ. Biomed. Opt.<\/em>,\u00a019<\/strong>\u00a0(9), 096002. (2014)<\/li>\n
                          7. Kimura, H., Yagi, Y., Ohneda, N., Odajima, H., Ono, M., Saji,\u00a0H.
                            \nDevelopment of a resonant-type microwave reactor and its application to the synthesis of PET radiopharmaceuticals
                            \nJ. Label. Compd. Radiopharm.<\/em>,\u00a057<\/strong>\u00a0(12), 680-686. (2014)<\/li>\n
                          8. Temma, T., Hanaoka, H., Yonezawa, A., Kondo, N., Sano, K., Sakamoto, T., Seiki, M., Ono, M.,\u00a0Saji, H.
                            \nInvestigation of a MMP-2 Activity-Dependent Anchoring Probe for Nuclear\u00a0Imaging of Cancer
                            \nPLoS ONE<\/em>,\u00a09<\/strong>\u00a0(7), e102180. (2014)<\/li>\n
                          9. Shimizu, Y., Temma, T., Hara, I., Makino, A., Kondo, N., Ozeki, EI., Ono, M., Saji, H.
                            \nIn vivo Imaging of Membrane Type-1 Matrix Metalloproteinase With a Novel\u00a0Activatable Near-Infrared Fluorescence Probe.
                            \nCancer Sci.<\/em>,\u00a0105<\/strong>\uff088), 1056-1062. (2014)<\/li>\n
                          10. Kimura, H., Matsuda, H., Fujimoto, H., Arimitsu, K., Toyoda, K., Mukai, E., Nakamura, H., Ogawa, Y., Takagi M, Ono M, Inagaki N, Saji H.
                            \nSynthesis and evaluation of\u00a018<\/sup>F-labeled mitiglinide derivatives as positron emission tomography tracers for \u03b2-cell imaging
                            \nBioorg. Med. Chem.<\/em>\u00a022<\/strong>(13) 3270-3278 (2014)<\/li>\n
                          11. Takai N, Tanaka Y, Saji H.
                            \nQuantification of Small Molecule Drugs in Biological Tissue Sections by Imaging Mass Spectrometry Using Surrogate Tissue-Based Calibration Standards
                            \nMass Spectrom.<\/em>\u00a03<\/strong>(1) A0025 (2014)<\/li>\n
                          12. Nishigori K, Temma T, Onoe S, Sampei S, Kimura I, Ono M, Saji H.
                            \nDevelopment of a radioiodinated triazolopyrimidine probe for nuclear medical\u00a0imaging of fatty acid binding protein-4
                            \nPLoS ONE<\/em>,\u00a09<\/strong>(4) e94668 (2014)<\/li>\n
                          13. Iikuni S, Ono M, Watanabe H, Matsumura K, Yoshimura M, Harada N, Kimura H, Nakayama M, Saji H.
                            \nEnhancement of Binding Affinity for Amyloid Aggregates by Multivalent Interactions of\u00a099m<\/sup>Tc-Hydroxamamide Complexes
                            \nMol. Pharmaceutics<\/em>,\u00a011<\/strong>(4) 1132-1139 (2014)<\/li>\n
                          14. Onoe S, Temma T, Shimizu Y, Ono M, Saji H.
                            \nInvestigation of Cyanine Dyes for\u00a0In Vivo<\/em>\u00a0Optical Imaging of Altered Mitochondrial Membrane Potential in Tumors
                            \nCancer Medicine<\/em>\u00a03<\/strong>(4) 775-786 (2014)<\/li>\n
                          15. Ueda M, Fukushima T, Ogawa K, Kimura H, Ono M, Yamaguchi T, Ikehara Y, Saji H.
                            \nSynthesis and evaluation of a radioiodinated peptide probe targeting \u03b1v\u03b26 integrin for the detection of pancreatic ductal adenocarcinoma
                            \nBiochem. Biophys. Res. Commun.<\/em>\u00a0445<\/strong>(3) 661-666 (2014)<\/li>\n
                          16. Cui M, Ono M, Watanabe H, Kimura H, Liu B, Saji H.
                            \nSmart Near-Infrared Fluorescence Probes with Donor-Acceptor Structure for in vivo Detection of \u03b2-Amyloid Deposits
                            \nJ. Am. Chem. Soc.<\/em>\u00a0136<\/strong>(9) 3388-3394 (2014)<\/li>\n
                          17. Sano K, Masuda R, Hisada H, Oishi S, Shimokawa K, Ono M, Fujii N, Saji H, Mukai T.
                            \nA radiogallium-DOTA-based bivalent peptidic ligand targeting a chemokine receptor, CXCR4, for tumor imaging
                            \nBioorg. Med. Chem. Lett.<\/em>\u00a024<\/strong>(5) 1386-1388 (2014)<\/li>\n
                          18. Watanabe H, Ono M, Kimura H, Matsumura K, Yoshimura M, Iikuni S, Okamoto Y, Ihara M, Takahashi R, Saji H.
                            \nNovel Radioiodinated 1,3,4-Oxadiazole Derivatives with Improved in Vivo Properties for SPECT Imaging of \u03b2-Amyloid Plaques
                            \nMed. Chem. Commun.<\/em>\u00a05<\/strong>(1) 82-85 (2014)<\/li>\n
                          19. Kimura H, Kawai T, Hamashima Y, Kawashima H, Miura K, Nakaya Y, Hirasawa M, Arimitsu K, Kajimoto T, Ohmomo Y, Ono M, Node M, Saji H.
                            \nSynthesis and Evaluation of (\u2212)- and (+)-[11<\/sup>C]Galanthamine as PET Tracers for Cerebral Acetylcholinesterase Imaging
                            \nBioorg. Med. Chem.<\/em>\u00a022<\/strong>(1) 285-291 (2014)<\/li>\n
                          20. Shimizu Y, Temma T, Hara I, Makino A, Yamahara R, Ozeki E.-i, Ono M, Saji H.
                            \nMicelle-based activatable probe for in vivo near-infrared optical imaging of cancer biomolecules
                            \nNanomedicine: NBM<\/em>\u00a010<\/strong>(1) 187-195 (2014)<\/li>\n<\/ol>\n

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                             <\/p>\n","protected":false},"excerpt":{"rendered":"

                            2025 Kashiyama R, Watanabe H, Akasaka T, Ono M. Novel amyloid-\u03b2 oligomer-targeted fluorescent probes by introd […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","footnotes":""},"class_list":["post-446","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/wp-json\/wp\/v2\/pages\/446","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/wp-json\/wp\/v2\/comments?post=446"}],"version-history":[{"count":5,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/wp-json\/wp\/v2\/pages\/446\/revisions"}],"predecessor-version":[{"id":3248,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/wp-json\/wp\/v2\/pages\/446\/revisions\/3248"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/en\/wp-json\/wp\/v2\/media?parent=446"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

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