{"id":145,"date":"2013-06-18T14:16:15","date_gmt":"2013-06-18T05:16:15","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=145"},"modified":"2025-03-24T18:20:24","modified_gmt":"2025-03-24T09:20:24","slug":"research10","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/molecular-imaging\/research10\/","title":{"rendered":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8a3a\u65ad\u306e\u305f\u3081\u306e\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u958b\u767a\u2460"},"content":{"rendered":"

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\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

 <\/p>\n

\u4e3b\u8981\u8ad6\u6587<\/h3>\n
    \n
  • Core Binding Site of a Thioflavin-T-derived Imaging Probe on Amyloid \u03b2 Fibrils Predicted by Computational Methods
    \nACS Chem. Neurosci.<\/em>\u00a09(5) 957-966 (2018)<\/span><\/li>\n
  • Development of Novel\u00a0123<\/sup>I-Labeled Pyridyl Benzofuran\u00a0Derivatives for SPECT Imaging of \u03b2-Amyloid Plaques in Alzheimer\u2019s Disease
    \nPLoS ONE<\/em>\u00a08\u00a0(9) e74104 (2013)<\/span><\/li>\n
  • Novel\u00a018<\/sup>F-labeled benzoxazole derivatives as potential positron emission tomography probes for imaging of cerebral \u03b2-amyloid plaques in alzheimers disease
    \nJ. Med. Chem.<\/em>\u00a055\u00a0(21) 9136-9145 (2012)<\/span><\/li>\n
  • Technetium-99m labeled pyridyl benzofuran derivatives as single photon emission computed tomography imaging probes for \u03b2-amyloid plaques in Alzheimer\u2019s brains
    \nJ. Med. Chem.<\/em>\u00a055\u00a0(5) 2279-2286 (2012)<\/span><\/li>\n
  • Novel\u00a018<\/sup>F-labeled benzofuran derivatives with improved properties for positron emission tomography (PET) imaging of \u03b2-amyloid plaques in Alzheimer\u2019s brains
    \nJ. Med. Chem.<\/em>\u00a054\u00a0(8) 2971-2979 (2011)<\/span><\/li>\n
  • Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for \u03b2-Amyloid Plaques
    \nJ. Med. Chem.<\/em>\u00a054\u00a0(7) 2225-2240 (2011)<\/span><\/li>\n
  • Synthesis and evaluation of novel chalcone derivatives with 99m<\/sup>Tc\/Re complexes as potential probes for detection of \u03b2-amyloid plaques.
    \nACS Chem. Neurosci.<\/em> 1\u00a0(9) 598-607 (2010)<\/span><\/li>\n
  • Novel radioiodinated aurones as probes for SPECT imaging of \u03b2-amyloid plaques in the brain.
    \nBioconjug. Chem.<\/em> 20 (1) 95-101 (2009)\u00a0<\/span><\/li>\n
  • Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of \u03b2-amyloid plaques in Alzheimer’s disease.
    \nJ Med. Chem.<\/em> 52 (20) 6394-401 (2009)<\/span><\/li>\n
  • Novel benzofuran derivatives for PET imaging of \u03b2-amyloid plaques in Alzheimer’s disease brains.
    \nJ. Med. Chem.<\/em> 49 2725-2730 (2006)<\/span><\/li>\n
  • Radioiodinated flavones for in vivo imaging of \u03b2-amyloid plaques in the brain.
    \nJ. Med. Chem.<\/em> 48 7253-7260 (2005)<\/span><\/li>\n
  • 11<\/sup>C-labeled stilbene derivatives as A\u03b2-aggregate-specific PET imaging agents for Alzheimer\u2019s disease.
    \nNucl. Med. Biol.<\/em> 30\u00a0565-571 (2003)<\/li>\n<\/ul>\n

    \u7dcf\u8aac\u7b49<\/h3>\n
      \n
    • Recent Advances in Molecular Imaging Probes for \u03b2-Amyloid Plaques<\/span>,
      \nMed. Chem. Commun<\/em>. <\/span>6(3) 391-402 (2015)<\/span><\/li>\n
    • SPECT imaging agents for detecting cerebral \u03b2-amyloid plaques.
      \nInternational Journal of Molecular Imaging<\/em>, Article ID 543267, doi:10.1155\/2011\/543267 (2011)<\/span><\/li>\n
    • PET\/SPECT imaging agents for detecting of cerebral \u03b2-amyloid plaques.
      \nCognition and Dementia<\/em>, 9, 13-18 (2010)<\/span><\/li>\n
    • \u5e73\u621021\u5e743\u67081\u65e5\u767a\u520a\u3001\u533b\u85ac\u30fb\u751f\u547d\u79d1\u5b66\u8a8c\u300c\u30e1\u30c7\u30a3\u30ab\u30eb\u30d0\u30a4\u30aa\u30002009\u5e743\u6708\u53f7\u300d\uff08p.84-87\uff09\u3001\u300c\u7b2c11\u56de\u5148\u99c6\u8005\u30d7\u30ec\u30ab\u30fc\u30b5\u30fc\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u65e9\u671f\u8a3a\u65ad\u3092\u53ef\u80fd\u306b\u3059\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u691c\u51fa\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\u300d<\/li>\n
    • PET\/SPECT\u306b\u3088\u308b\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u7814\u7a76\u3001
      \n\u85ac\u5b66\u96d1\u8a8c<\/em>. 129(3) 279-287 (2009)<\/li>\n
    • Development of positron-emission tomography\/single-photon emission computed tomography imaging probes for in vivo detection of \u03b2-amyloid plaques in Alzheimer’s brains.
      \nChem Pharm Bull (Tokyo)<\/em>. \u00a057(10)1029-1039 (2009)<\/li>\n
    • PET\/SPECT\u306b\u3088\u308b\u03b2\u30a2\u30df\u30ed\u30a4\u30c9\u306e\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\uff5e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u65e9\u671f\u8a3a\u65ad\u3092\u76ee\u6307\u3057\u3066
      \n\u5316\u5b66<\/em>, 63, 64-65 (2008)<\/li>\n
    • PET\/SPECT\u3092\u7528\u3044\u305f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u753b\u50cf\u8a3a\u65ad\u3001
      \n\u85ac\u5264\u5b66<\/em>\u300168, 209-216 (2008)<\/li>\n
    • Molecular imaging of \u03b2-amyloid plaques in the brain.
      \nBrain Nerve<\/em>, 59, 233-240 (2007)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

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