{"id":151,"date":"2013-06-18T14:22:56","date_gmt":"2013-06-18T05:22:56","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=151"},"modified":"2023-04-06T13:22:50","modified_gmt":"2023-04-06T04:22:50","slug":"research13","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/molecular-imaging\/research13\/","title":{"rendered":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8a3a\u65ad\u306e\u305f\u3081\u306e\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u958b\u767a\u2461"},"content":{"rendered":"<h2>\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/h2>\n<p>\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316(NFT)\u306e\u4e3b\u6210\u5206\u3067\u3042\u308b\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5(AD)\u767a\u75c7\u65e9\u671f\u304b\u3089\u8a8d\u3081\u3089\u308c\u3001\u8a18\u61b6\u30fb\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306a\u3069\u306e\u81e8\u5e8a\u75c7\u72b6\u3068\u9ad8\u3044\u76f8\u95a2\u6027\u3092\u793a\u3059\u3053\u3068\u304b\u3089\u3001\u75c5\u72b6\u9032\u884c\u306e\u5224\u5b9a\u306b\u6709\u52b9\u3068\u3055\u308c\u3066\u304d\u305f\u3002\u307e\u305f\u3001AD\u4ee5\u5916\u306b\u3082\u30bf\u30a6\u84c4\u7a4d\u304c\u8a8d\u3081\u3089\u308c\u308b\u75be\u60a3\u304c\u5b58\u5728\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u8a3a\u65ad\u306b\u3082\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u30bf\u30a6\u51dd\u96c6\u4f53\u3092\u6a19\u7684\u3068\u3057\u305f\u653e\u5c04\u6027\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\u7814\u7a76\u3092\u884c\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n<p><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2022\/06\/\u30bf\u30a6\u7d39\u4ecb1-1.png\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2795\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2022\/06\/\u30bf\u30a6\u7d39\u4ecb1-1.png\" alt=\"\" width=\"841\" height=\"595\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2022\/06\/\u30bf\u30a6\u7d39\u4ecb1-1.png 841w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2022\/06\/\u30bf\u30a6\u7d39\u4ecb1-1-300x212.png 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2022\/06\/\u30bf\u30a6\u7d39\u4ecb1-1-768x543.png 768w\" sizes=\"auto, (max-width: 841px) 100vw, 841px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li><span style=\"font-size: 14px;text-indent: 1em\">Characterization and Optimization of Radioiodinated Benzimidazopyrimidine and Pyridoimidazopyridine Derivatives for Development of Tau Imaging Probes<\/span><br \/>\n<em>ACS Med. Chem. Lett.<\/em>\u00a0<strong>12<\/strong>(5) 805-811 (2021)<\/li>\n<li><span style=\"font-size: 14px;text-indent: 1em\">Structure-Activity and Brain Kinetics Relationships of <sup>18<\/sup>F Labeled Benzimidazopyridine Derivatives as Tau PET Tracers<\/span><br \/>\n<em>ACS Med. Chem. Lett.<\/em>\u00a0<strong>12<\/strong>(2) 262-266 (2021)<\/li>\n<li><span style=\"font-size: 14px;text-indent: 1em\">Structure-activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes<\/span><br \/>\n<em>ACS Med. Chem. Lett.<\/em>\u00a0<strong>11<\/strong>(2) 120-126 (2020)<\/li>\n<li><span style=\"font-size: 14px;text-indent: 1em\">Structure-activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology<\/span><br \/>\n<em>ACS Med. Chem. Lett.<\/em>\u00a0<b>9<\/b>(5) 478-483 (2018)<\/li>\n<li>Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer\u2019s Disease<br \/>\n<em>Sci. Rep.<\/em>,\u00a0<b>6<\/b>\u00a034197 (2016)<\/li>\n<li>Structure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents that Selectively Detect Neurofibrillary Tangles in Alzheimer\u2019s Disease Brains<br \/>\n<em>J. Med. Chem.<\/em>\u00a0<b>58<\/b>(8) 7241-7257 (2015)<\/li>\n<li><sup>18<\/sup>F-labeled phenyldiazenyl benzothiazole for in vivo imaging of neurofibrillary tangles in Alzheimer\u2019s disease brains.<br \/>\n<em>ACS Med. Chem. Lett.<\/em>\u00a0<strong>3<\/strong>(1) 58-62 (2012)<\/li>\n<li>Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer&#8217;s brains<br \/>\n<span class=\"Apple-style-span\"><em>ACS Chem. Neurosci.<\/em>\u00a0<strong>2<\/strong>(5) 269-275 (2011)<\/span><\/li>\n<\/ul>\n<h3>\u7dcf\u8aac\u7b49<\/h3>\n<ul>\n<li>\u30bf\u30a6\u306ePET\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<br \/>\n<em>\u8133\u795e\u7d4c\u5185\u79d1<\/em>\u3001<strong>91<\/strong>(1), 48-53 (2019).<\/li>\n<li>Novel PET\/SPECT Probes for Imaging of Tau in Alzheimer\u2019s Disease<br \/>\n<span class=\"Apple-style-span\"><em>ScientificWorldJournal\u00a0<\/em><strong>2015<\/strong> 124192 (2015)<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a \u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316(NFT)\u306e\u4e3b\u6210\u5206\u3067\u3042\u308b\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5(AD)\u767a\u75c7\u65e9\u671f\u304b\u3089\u8a8d\u3081\u3089\u308c\u3001\u8a18\u61b6\u30fb\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306a\u3069\u306e\u81e8\u5e8a\u75c7\u72b6\u3068\u9ad8\u3044\u76f8\u95a2\u6027\u3092\u793a\u3059\u3053\u3068\u304b\u3089\u3001\u75c5\u72b6\u9032\u884c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":133,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","footnotes":""},"class_list":["post-151","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=151"}],"version-history":[{"count":5,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/151\/revisions"}],"predecessor-version":[{"id":2866,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/151\/revisions\/2866"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/133"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}