{"id":156,"date":"2013-06-18T14:35:10","date_gmt":"2013-06-18T05:35:10","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=156"},"modified":"2020-01-18T11:16:23","modified_gmt":"2020-01-18T02:16:23","slug":"research01","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/history\/research01\/","title":{"rendered":"\u8133\u6a5f\u80fd\u3001\u5fc3\u6a5f\u80fd\u304a\u3088\u3073\u708e\u75c7\u53cd\u5fdc\u306e\u5206\u6790\u306e\u305f\u3081\u306e\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a"},"content":{"rendered":"<h2>\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u653e\u5c04\u6027\u30d7\u30ed\u30fc\u30d6\uff1a 5-[<sup>123<\/sup>I]I-A85380([<sup>123<\/sup>I]5IA) \u306e\u958b\u767a<\/h2>\n<p>\u4e2d\u67a2\u306b\u5b58\u5728\u3059\u308b\u30cb\u30b3\u30c1\u30f3\u6027\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u53d7\u5bb9\u4f53\u306f\u3001\u8a18\u61b6\u30fb\u8a8d\u77e5\u3068\u3044\u3063\u305f\u9ad8\u6b21\u8133\u6a5f\u80fd\u3084\u795e\u7d4c\u4fdd\u8b77\u30fb\u93ae\u75db\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u6a5f\u80fd\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u5bc6\u5ea6\u3092\u4f53\u5916\u304b\u3089\u975e\u4fb5\u8972\u7684\u306b\u6e2c\u5b9a\u3067\u304d\u308c\u3070\u3001\u305d\u308c\u3089\u306e\u6a5f\u80fd\u3068\u53d7\u5bb9\u4f53\u5bc6\u5ea6\u3068\u306e\u95a2\u9023\u3092\u8a73\u7d30\u306b\u691c\u8a0e\u3067\u304d\u308b\u306e\u307f\u306a\u3089\u305a\u3001\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u5bc6\u5ea6\u304c\u5909\u5316\u3059\u308b\u75be\u60a3\u306e\u8a3a\u65ad\u30fb\u75c5\u614b\u628a\u63e1\u306b\u7e4b\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3053\u3068\u304b\u3089\u975e\u5e38\u306b\u610f\u7fa9\u6df1\u3044\u3002<\/p>\n<p>\u6211\u3005\u306f\u3053\u308c\u307e\u3067\u306b\u3001\u6709\u7528\u6027\u306e\u9ad8\u3044\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u7d50\u5408\u653e\u5c04\u6027\u85ac\u5264\u3068\u3057\u30665-[<sup>123<\/sup>I]I-A85380\uff08[<sup>123<\/sup>I]5IA\uff09\u3092\u958b\u767a\u3057\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3068\u305d\u306e\u5b9a\u91cf\u89e3\u6790\u6cd5\u3092\u78ba\u7acb\u3057\u305f\uff08\u56f3\uff11\uff09\u3002\u305d\u3057\u3066\u305d\u306e\u65b9\u6cd5\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u55ab\u7159\u8005\u306e\u8133\u5185\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3068\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3078\u306e\u56de\u5fa9\u3092\u6349\u3048\u3001\u30d2\u30c8\u8133\u5185\u306b\u304a\u3051\u308b\u53d7\u5bb9\u4f53\u306e\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306a\u5909\u5316\u3092\u6349\u3048\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u305f\uff08\u56f3\uff12\uff09\u3002\u307e\u305f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u3067\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3057\u3066\u304a\u308a\u3001\u75c5\u614b\u306b\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u3082\u793a\u3055\u308c\u305f\uff08\u56f3\uff13\uff09\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u975e\u6a19\u8b58\u306e5IA\u306f\u30a2\u30b4\u30cb\u30b9\u30c8\u4f5c\u7528\u3092\u6709\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306b\u5bfe\u3059\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u6bd2\u6027\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3001\u305d\u306e\u4f5c\u7528\u306b\u306f\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u306e\u03b14\u03b22\u30b5\u30d6\u30bf\u30a4\u30d7\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\uff08\u56f3\uff14\u3001\uff15\uff09\u3002\u307e\u305f\u3001\u30e2\u30eb\u30d2\u30cd\u306a\u3069\u306e\u9ebb\u85ac\u6027\u93ae\u75db\u85ac\u304c\u52b9\u679c\u3092\u793a\u3057\u306b\u304f\u3044\u795e\u7d4c\u56e0\u6027\u75bc\u75db\u306b\u304a\u3044\u3066\u306f\u3001\u30e2\u30c7\u30eb\u52d5\u7269\u306e\u8996\u5e8a\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u304c\u5897\u52a0\u3057\u3066\u304a\u308a\u30015IA\u306e\u8996\u5e8a\u5185\u6295\u4e0e\u3067\u7528\u91cf\u4f9d\u5b58\u7684\u306a\u93ae\u75db\u4f5c\u7528\u304c\u8a8d\u3081\u3089\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u8996\u5e8a\u306b\u5b58\u5728\u3059\u308b\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u304c\u795e\u7d4c\u56e0\u6027\u75bc\u75db\u6291\u5236\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u3092\u898b\u51fa\u3057\u305f\uff08\u56f3\uff16\uff5e\uff18\uff09\u3002<\/p>\n<div id=\"attachment_159\" style=\"width: 658px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/5IA-3.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-159\" class=\" wp-image-159 \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/5IA-3.jpg\" alt=\"5IA-3\" width=\"648\" height=\"432\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/5IA-3.jpg 1080w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/5IA-3-300x200.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/5IA-3-1024x682.jpg 1024w\" sizes=\"auto, (max-width: 648px) 100vw, 648px\" \/><\/a><p id=\"caption-attachment-159\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<div id=\"attachment_158\" style=\"width: 624px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/5IA-4.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-158\" class=\" wp-image-158 \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/5IA-4-1024x682.jpg\" alt=\"5IA-4\" width=\"614\" height=\"409\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/5IA-4-1024x682.jpg 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/5IA-4-300x200.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/5IA-4.jpg 1080w\" sizes=\"auto, (max-width: 614px) 100vw, 614px\" \/><\/a><p id=\"caption-attachment-158\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u95a2\u9023\u6587\u732e<\/h3>\n<ul>\n<li><\/li>\n<li>In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: Persistent agonist binding inhibits the expression of antiallodynic effects.<br \/>\nSynapse. 2011 Jan;65(1):77-83.<\/li>\n<li>Nicotinic acetylcholine receptors expressed in the ventral posterolateral thalamic nucleus play an important role in antiallodynic effects.<br \/>\nBr J Pharmacol. 2010 Mar;159(6):1201-10.<\/li>\n<li>5-Iodo-A-85380, a specific ligand for alpha 4 beta 2 nicotinic acetylcholine receptors, prevents glutamate neurotoxicity in rat cortical cultured neurons.<br \/>\nBrain Res. 2008 Mar 14;1199:46-52.<\/li>\n<li>Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study.<br \/>\nJ Nucl Med. 2007 Nov;48(11):1829-35.<\/li>\n<li>Quantification of nicotinic acetylcholine receptors in Parkinson&#8217;s disease with (123)I-5IA SPECT.<br \/>\nJ Neurol Sci. 2007 May 15;256(1-2):52-60.<\/li>\n<li>Quantification of human nicotinic acetylcholine receptors with\u00a0<sup>123<\/sup>I-5IA SPECT.<br \/>\nJ Nucl Med. 2004;45(9):1458-1470.<\/li>\n<li>5-[123I]Iodo-A-85380: assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects.<br \/>\nAnn Nucl Med. 2004;18(4):337-344.<\/li>\n<li>Evaluation of 5-11C-methyl-A-85380 as an imaging agent for PET investigations of brain nicotinic acetylcholine receptors.<br \/>\nJ Nucl Med. 2004 May;45(5):878-84.<\/li>\n<li>Evaluation of radioiodinated 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine as a ligand for SPECT investigations of brain nicotinic acetylcholine receptors.<br \/>\nAnn Nucl Med. 2002;16(3):189-200.<\/li>\n<\/ul>\n<h2 id=\"title2\">\u8133\u5185\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u306e\u958b\u767a<\/h2>\n<p>\u3046\u3064\u75c5\u3084\u6ce8\u610f\u6b20\u9665\u591a\u52d5\u969c\u5bb3\uff08ADHD\uff09\u306a\u3069\u306e\u6a5f\u80fd\u6027\u7cbe\u795e\u75be\u60a3\u60a3\u8005\u306e\u6570\u306f\u5897\u52a0\u306e\u4e00\u9014\u3092\u305f\u3069\u3063\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u75c5\u614b\u306e\u89e3\u660e\u306f\u4ed6\u306e\u8133\u795e\u7d4c\u75be\u60a3\u306b\u6bd4\u3079\u308b\u3068\u9045\u308c\u3092\u53d6\u3063\u3066\u3044\u308b\u3002\u305d\u306e\u539f\u56e0\u306e\uff11\u3064\u3068\u3057\u3066\u3001\u305d\u308c\u3089\u306e\u75be\u60a3\u3068\u306e\u95a2\u9023\u304c\u9577\u5e74\u306b\u308f\u305f\u308a\u6307\u6458\u3055\u308c\u3066\u304d\u305f\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\uff08NA\uff09\u795e\u7d4c\u6a5f\u80fd\u3092\u3001\u30a4\u30f3\u30d3\u30dc\u3067\u8a55\u4fa1\u3067\u304d\u308b\u65b9\u6cd5\u304c\u306a\u3044\u3053\u3068\u304c\u3042\u3052\u3089\u308c\u308b\u3002\u305d\u3053\u3067\u6211\u3005\u306f\u3001NA\u795e\u7d4c\u6a5f\u80fd\u3092\u4f53\u5916\u304b\u3089\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3001\u8133\u5185NET\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u306e\u958b\u767a\u3092\u8a08\u753b\u3057\u305f\u3002<\/p>\n<p>\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u306e\u6bcd\u4f53\u9aa8\u683c\u3068\u3057\u3066\u306fNET\u306b\u9ad8\u3044\u89aa\u548c\u6027\u3001\u9078\u629e\u6027\u3092\u6301\u3064reboxetine\u3092\u9078\u629e\u3057\u305f\u3002Reboxetine\u3068\u985e\u4f3c\u306e\u5316\u5408\u7269\u306b\u304a\u3051\u308bphenoxy2\u4f4d\u3078\u306e\u30e8\u30a6\u7d20\u306e\u5c0e\u5165\u306fNET\u3078\u306e\u7d50\u5408\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\u3068\u3044\u3046\u6211\u3005\u306e\u4ee5\u524d\u306e\u5831\u544a\u3092\u3082\u3068\u306b\u3001reboxetine\u306ephenoxy\u57fa2\u4f4d\u306b<sup>123<\/sup>I\u3092\u5c0e\u5165\u3057\u305f\u3001(S,S)-[<sup>123<\/sup>I]-2-(alpha-(2-iodophenoxy)benzyl)morpholine((S,S)-[<sup>123<\/sup>I]IPBM)\u3092\u8a2d\u8a08\u3001\u5408\u6210\u3057\u305f\u3002<\/p>\n<p>\u30a4\u30f3\u30d3\u30c8\u30ed\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001(S,S)-IPBM \u306eNET\u306b\u5bfe\u3059\u308b\u7d50\u5408\u89aa\u548c\u6027\u3092\u691c\u8a0e\u3057\u305f\u7d50\u679c\u3001(S,S)-IPBM\u306fNET\u306b\u7d50\u5408\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u6c4e\u7528\u3055\u308c\u3066\u3044\u308bnisoxetine\u3068\u307b\u307c\u540c\u7b49\u306e\u89aa\u548c\u6027\u3092\u6301\u3064\u3053\u3068\u3092\u8a8d\u3081\u305f\u3002\u307e\u305f\u3001(S,S)-[<sup>125<\/sup>I]IPBM\u3092\u653e\u5c04\u6027\u30ea\u30ac\u30f3\u30c9\u3068\u3059\u308b\u30e9\u30b8\u30aa\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308a\u3001(S,S)-IPBM\u306f\u9ad8\u3044NET\u7d50\u5408\u9078\u629e\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u3082\u898b\u3044\u3060\u3057\u305f\u3002<\/p>\n<p>\u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u30a4\u30f3\u30d3\u30dc\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001 (S,S)-[<sup>125<\/sup>I]IPBM\u306f\u6295\u4e0e\u5f8c\u901f\u3084\u304b\u306b\u8133\u306b\u79fb\u884c\u3057\u3001\u305d\u306e\u96c6\u7a4d\u306f\u6301\u7d9a\u3059\u308b\u3053\u3068\u3001\u3055\u3089\u306b\u3001\u8133\u5185\u3067\u306e\u8a73\u7d30\u306a\u5206\u5e03\u306fNET\u306e\u5206\u5e03\u3068\u307b\u307c\u7b49\u3057\u3044\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u305f\u3002\u307e\u305f\u3001\u30b3\u30e2\u30f3\u30fb\u30de\u30fc\u30e2\u30bb\u30c3\u30c8\u3092\u7528\u3044\u305fSPECT\u64ae\u50cf\u5b9f\u9a13\u3067\u306f\u3001NET\u5206\u5e03\u5bc6\u5ea6\u306e\u9ad8\u3044\u8996\u5e8a\u3084\u76ae\u8cea\u3078\u306e(S,S)-[<sup>123<\/sup>I]IPBM\u306e\u96c6\u7a4d\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u672c\u5316\u5408\u7269\u306b\u3064\u3044\u3066\u306f\u3001\u5fc3\u6a5f\u80fd\u8a3a\u65ad\u30d7\u30ed\u30fc\u30d6\u3068\u3057\u3066\u306e\u6709\u52b9\u6027\u8a55\u4fa1\u7814\u7a76\u3082\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n<div id=\"attachment_157\" style=\"width: 658px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/IPBM.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-157\" class=\" wp-image-157 \" title=\"\u8133\u5185\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u306e\u958b\u767a\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/IPBM.jpg\" alt=\"IPBM\" width=\"648\" height=\"432\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/IPBM.jpg 810w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/IPBM-300x200.jpg 300w\" sizes=\"auto, (max-width: 648px) 100vw, 648px\" \/><\/a><p id=\"caption-attachment-157\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u95a2\u9023\u6587\u732e<\/h3>\n<ul>\n<li>Synthesis and evaluation of radioiodinated (S,S)-2-(alpha-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter.<br \/>\nEur J Nucl Med Mol Imaging 2006;33(6):639-647.<\/li>\n<li>Evaluation of radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine as a ligand for brain norepinephrine transporter imaging.<br \/>\nNucl Med Biol. 2004;31(2):147-153.<\/li>\n<li>A new norepinephrine transporter imaging agent for cardiac sympathetic nervous function imaging: radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine.<br \/>\nNucl Med Biol. 2003;30(7):697-706.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>\u9759\u8108\u5185\u6295\u4e0e\u578bO-15\u6a19\u8b58O<sub>2<\/sub>\u5264\uff08Injectable [<sup>15<\/sup>O]O<sub>2<\/sub>\uff09\u306b\u3088\u308b\u30d6\u30bf\u5fc3\u7b4b\u9178\u7d20\u6442\u53d6\u7387\u306e\u6e2c\u5b9a<\/h2>\n<p>\u30e9\u30c3\u30c8\u8133\u9178\u7d20\u4ee3\u8b1d\u6e2c\u5b9a\u3092\u76ee\u7684\u3068\u3057\u3066\u958b\u767a\u3057\u305f\u9759\u8108\u5185\u6295\u4e0e\u578bO-15\u6a19\u8b58O<sub>2<\/sub>\u5264\uff08Injectable [<sup>15<\/sup>O]O2\uff09\u306b\u3064\u3044\u3066\u3001\u5468\u56f2\u9ad8\u653e\u5c04\u80fd\u306e\u5f71\u97ff\u3092\u30ad\u30e3\u30f3\u30bb\u30eb\u30a2\u30a6\u30c8\u3057\u3066\u5bfe\u8c61\u7d44\u7e54\u306e\u9178\u7d20\u4ee3\u8b1d\u3092\u8a55\u4fa1\u3067\u304d\u308b\u7279\u5fb4\u306b\u7740\u76ee\u3057\u3001[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u5438\u5165\u6cd5\u3067\u306f\u5468\u56f2\uff08\u80ba\uff09\u306b\u5b58\u5728\u3059\u308b\u9ad8\u3044\u653e\u5c04\u80fd\u304c\u89e3\u6790\u4e0a\u306e\u56f0\u96e3\u3055\u3092\u5897\u3059\u5fc3\u7b4b\u306b\u304a\u3051\u308b\u9178\u7d20\u4ee3\u8b1d\u6e2c\u5b9a\u3078\u306e\u5fdc\u7528\u3092\u691c\u8a0e\u3057\u305f\u3002<\/p>\n<p>\u52d5\u7269\u306b\u306f\u30df\u30cb\u30d6\u30bf\u3092\u7528\u3044\u3001Injectable [<sup>15<\/sup>O]O<sub>2<\/sub>\u3092\u6025\u901f\u975c\u6ce8\u3059\u308binjection\u6cd5\u3068\u3001\u5927\u817f\u52d5\u9759\u8108\u9593\u3092\u4eba\u5de5\u80ba\u3092\u4ecb\u3057\u3066\u63a5\u7d9a\u3057\u4eba\u5de5\u80ba\u3088\u308a\u6301\u7d9a\u7684\u306b[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u3092\u4f9b\u7d66\u3059\u308bcontinuous infusion\u6cd5\u3092\u65bd\u884c\u3057\u3066\u3001[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u5438\u5165\u6cd5\uff08continuous inhalation\u6cd5\uff09\u3068\u6bd4\u8f03\u691c\u8a0e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001injection\u6cd5\u3001continuous infusion\u6cd5\u3067\u306fcontinuous inhalation\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u80ba\u306b\u304a\u3051\u308b\u653e\u5c04\u80fd\u3092\u5927\u304d\u304f\u6e1b\u5f31\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u5fc3\u7b4b\u5074\u58c1\u306b\u304a\u3044\u3066\u540c\u7b49\u306e\u9178\u7d20\u6442\u53d6\u7387\uff08OEF)\u3092\u6e2c\u5b9a\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/p>\n<div id=\"attachment_166\" style=\"width: 624px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/pig_for_HP.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-166\" class=\" wp-image-166 \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/pig_for_HP.jpg\" alt=\"pig_for_HP\" width=\"614\" height=\"461\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/pig_for_HP.jpg 960w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/pig_for_HP-300x225.jpg 300w\" sizes=\"auto, (max-width: 614px) 100vw, 614px\" \/><\/a><p id=\"caption-attachment-166\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li>Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable <sup>15<\/sup>O-O<sub>2<\/sub>.<br \/>\nEur J Nucl Med Mol Imaging. 2010 Feb;37(2):377-85.<\/li>\n<\/ul>\n<h2>\u5fc3\u81d3\u4ea4\u611f\u795e\u7d4c\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u305f\u3081\u306e\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u306e\u958b\u767a<\/h2>\n<p>\u5fc3\u81d3\u4ea4\u611f\u795e\u7d4c\u306e\u795e\u7d4c\u7d42\u672b\u30d7\u30ec\u30b7\u30ca\u30d7\u30b9\u306b\u306f\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc (NET) \u304c\u5b58\u5728\u3057\u3001\u7a2e\u3005\u306e\u5fc3\u75be\u60a3\u306b\u304a\u3044\u3066\u3001\u3053\u306eNET\u306e\u767a\u73fe\u91cf\u306b\u5909\u5316\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001NET\u306e\u5909\u5316\u3092\u4f53\u5916\u304b\u3089\u691c\u51fa\u3059\u308b\u3053\u3068\u306f\u3001\u3053\u308c\u3089\u306e\u75c5\u614b\u306b\u95a2\u3059\u308b\u6709\u7528\u306a\u60c5\u5831\u3092\u4e0e\u3048\u3046\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u6211\u3005\u306f\u3053\u308c\u307e\u3067\u306b<a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/molecular-imaging\/research01\/#title2\" title=\"\u8133\u6a5f\u80fd\u5206\u6790\u306e\u305f\u3081\u306e\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\" class=\"liexternal\">\u8133\u5185NET\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u3068\u3057\u3066(S,S)-[<sup>123<\/sup>I]IPBM\u306e\u6709\u52b9\u6027\u3092\u660e\u3089\u304b\u3068\u3057\u3066\u3044\u308b<\/a>\u3053\u3068\u304b\u3089\u3001\u672c\u5316\u5408\u7269\u306e\u5fc3\u81d3NET\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u3068\u3057\u3066\u306e\u5fdc\u7528\u6027\u3092\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n<p>\u30a4\u30f3\u30d3\u30c8\u30ed\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001 (S,S)-IPBM\u306fNET\u306b\u7d50\u5408\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u6c4e\u7528\u3055\u308c\u3066\u3044\u308bnisoxetine\u3084\u6bcd\u4f53\u5316\u5408\u7269\u306ereboxetine\u3068\u307b\u307c\u540c\u7b49\u306e\u89aa\u548c\u6027\u3092\u6301\u3064\u3053\u3068\u3092\u8a8d\u3081\u305f\uff08\u56f3\uff12\uff09\u3002\u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u30a4\u30f3\u30d3\u30dc\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001 (S,S)-[<sup>125<\/sup>I]IPBM\u306f\u901f\u3084\u304b\u304b\u3064\u9ad8\u3044\u5fc3\u81d3\u3078\u306e\u53d6\u308a\u8fbc\u307f\u3092\u793a\u3057\u3001\u653e\u5c04\u80fd\u306e\u5fc3\u81d3\u8840\u6db2\u6bd4\u306f\u7d4c\u6642\u7684\u306b\u5897\u5927\u3057\u305f\uff08\u56f3\uff13\uff09\u3002\u3055\u3089\u306b\u5404\u30e2\u30ce\u30a2\u30df\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u7d50\u5408\u5264\u3092\u6295\u4e0e\u3057\u305f\u3068\u304d\u306e(S,S)-[<sup>125<\/sup>I]IPBM\u306e\u5fc3\u96c6\u7a4d\u3092\u8a55\u4fa1\u3057\u305f\u3068\u3053\u308d\u3001NET\u7d50\u5408\u5264\u3067\u3042\u308bnisoxetine\u3084desipramine\u306b\u3088\u3063\u3066\u306e\u307f\u96c6\u7a4d\u304c\u963b\u5bb3\u3055\u308c\u305f\u3053\u3068\u304b\u3089\u3001(S,S)-[<sup>125<\/sup>I]IPBM\u304c\u30a4\u30f3\u30d3\u30dc\u3067\u3082NET\u306b\u9078\u629e\u7684\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff08\u56f3\uff14\uff09\u3002<br \/>\n\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001(S,S)-[<sup>123<\/sup>I]IPBM\u304cNET\u3092\u6a19\u7684\u3068\u3057\u305f\u5fc3\u6a5f\u80fd\u8a3a\u65ad\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u3068\u3057\u3066\u6709\u7528\u306a\u6027\u8cea\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<div id=\"attachment_165\" style=\"width: 615px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/IPBM_for_Heart.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-165\" class=\" wp-image-165 \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/IPBM_for_Heart.jpg\" alt=\"IPBM_for_Heart\" width=\"605\" height=\"403\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/IPBM_for_Heart.jpg 1080w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/IPBM_for_Heart-300x200.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/IPBM_for_Heart-1024x682.jpg 1024w\" sizes=\"auto, (max-width: 605px) 100vw, 605px\" \/><\/a><p id=\"caption-attachment-165\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li>Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.<br \/>\nNucl Med Biol. 2008 Feb;35(2):213-8.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>\u30b7\u30af\u30ed\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc-2\uff08COX-2\uff09\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u7528\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/h2>\n<p>\u30b7\u30af\u30ed\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\uff08COX\uff09\u306f\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u5408\u6210\u306e\u5f8b\u901f\u9175\u7d20\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u3002\u3053\u306eCOX\u306e\u8a98\u5c0e\u578b\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3067\u3042\u308bCOX-2\u306f\u708e\u75c7\u3001\u816b\u760d\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u69d8\u3005\u306a\u75be\u60a3\u306e\u75c5\u614b\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001COX-2\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u306e\u958b\u767a\u3092\u76ee\u7684\u3068\u3057\u3001\uff12\u7a2e\u306eCelecoxib\u8a98\u5c0e\u4f53\uff08IMTP\uff1b\u30b9\u30eb\u30db\u30f3\u9178\u30e1\u30c1\u30eb\u30bf\u30a4\u30d7\u3001IATP;\u30b9\u30eb\u30db\u30f3\u9178\u30a2 \u30df\u30c9\u30bf\u30a4\u30d7\uff09\u306eCOX\u963b\u5bb3\u6d3b\u6027\u30fb\u4f53\u5185\u52d5\u614b\u3092\u6bd4\u8f03\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001IMTP\u3001IATP\u306f\u9ad8\u3044COX\u963b\u5bb3\u6d3b\u6027\u3068\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u9078\u629e\u6027\u3092\u6709\u3057\u3066\u3044\u305f\u3002\u307e\u305f\u3001\u30e9\u30c3 \u30c8\u306e\u4f53\u5185\u5206\u5e03\u5b9f\u9a13\u306b\u304a\u3044\u3066\u3001[<sup>125<\/sup>I]IMTP\u306f[<sup>125<\/sup>I]IATP\u3088\u308a\u3082\u901f\u3084\u304b\u306a\u8840\u4e2d\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u793a\u3057\u305f\u3002[<sup>125<\/sup>I]IATP\u306e\u8840\u4e2d\u79fb\u884c\u7387\uff0888.0%\uff09\u306f[<sup>125<\/sup>I]IMTP\uff0818.1%\uff09\u3088\u308a\u306f\u308b\u304b\u306b\u9ad8\u304f\u3001\u70ad\u9178\u8131\u6c34\u9175\u7d20\uff08CA\uff09\u963b\u5bb3\u5264\u306b\u3088\u3063\u3066\u4f4e\u4e0b\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u30b9\u30eb\u30db\u30f3\u9178\u30e1\u30c1\u30eb\u30bf\u30a4\u30d7\u3067\u3042\u308b[<sup>125<\/sup>I]IMTP\u304cCOX-2\u9078\u629e\u7684\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u3068\u3057\u3066\u3001\u3088\u308a\u512a\u308c\u305f\u6027\u8cea\u3092\u6301\u3064\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u305f\u3002<\/p>\n<p>\u3057\u304b\u3057\u306a\u304c\u3089\u3001Celecoxib\u306a\u3069\u306e\u4e09\u74b0\u7cfbCOX-2\u9078\u629e\u7684\u963b\u5bb3\u5264\u3092\u6bcd\u4f53\u5316\u5408\u7269\u3068\u3059\u308b\u653e\u5c04\u6027\u6a19\u8b58\u5316\u5408\u7269\u306b\u3064\u3044\u3066\u306f\u3001\u708e\u75c7\u30e2\u30c7\u30eb\u52d5\u7269\u3092\u7528\u3044\u305f\u691c\u8a0e\u3067\u3001 \u75c5\u5909\u90e8\u3078\u306e\u96c6\u7a4d\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u4e00\u65b9\u3001\u4e09\u74b0\u69cb\u9020\u4ee5\u5916\u306eCOX-2\u9078\u629e\u7684\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u306f\u5831\u544a\u304c\u306a\u3044\u3053\u3068\u304b\u3089\u3001\u75c5\u5909\u90e8\u3078\u96c6\u7a4d\u3057\u306a\u3044\u539f\u56e0\u306e\u4e00\u3064\u306b\u306f\u3001\u5316\u5408 \u7269\u306b\u5171\u901a\u3057\u305f\u4e09\u74b0\u69cb\u9020\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3001\u6b21\u306b\u3001Celecoxib\u985e\u3068\u306f\u7570\u306a\u308b\u69cb\u9020\u3092\u6709\u3059\u308b\u65b0\u898fCOX-2\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u85ac\u5264\u306e\u5275\u88fd\u3092\u8a66\u307f\u308b\u3053\u3068\u3068\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001\u4e09\u74b0\u69cb\u9020\u3092\u3068\u3089\u305a\u3001COX-2\u3078\u306e\u963b\u5bb3\u6d3b\u6027\u3001\u9078\u629e\u6027\u306e\u9ad8\u3044\u963b\u5bb3\u5264\u3067\u3042\u308bLumiracoxib\u3092\u6bcd\u4f53\u5316\u5408\u7269\u306b\u3001\u653e\u5c04\u6027\u540c\u4f4d\u5143\u7d20\u3092 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style=\"width: 727px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/FIMA_for_HP.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-283\" class=\" wp-image-283\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/FIMA_for_HP-1024x682.jpg\" alt=\"FIMA_for_HP\" width=\"717\" height=\"477\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/FIMA_for_HP-1024x682.jpg 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/FIMA_for_HP-300x200.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/FIMA_for_HP.jpg 1080w\" sizes=\"auto, (max-width: 717px) 100vw, 717px\" \/><\/a><p id=\"caption-attachment-283\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<div id=\"attachment_284\" style=\"width: 1034px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/COX-2.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-284\" class=\" wp-image-284\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/COX-2-1024x682.jpg\" alt=\"COX-2\" width=\"1024\" height=\"682\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/COX-2-1024x682.jpg 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/COX-2-300x199.jpg 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><p id=\"caption-attachment-284\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li>Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression<br \/>\nNucl Med Biol 2009;36(8):869-76<\/li>\n<li>Synthesis and evaluationo of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression.<br \/>\nNucl Med Biol 2006;33(1):21-7.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u653e\u5c04\u6027\u30d7\u30ed\u30fc\u30d6\uff1a 5-[123I]I-A85380([123I]5IA) \u306e\u958b\u767a \u4e2d\u67a2\u306b\u5b58\u5728\u3059\u308b\u30cb\u30b3\u30c1\u30f3\u6027\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u53d7\u5bb9\u4f53\u306f\u3001\u8a18\u61b6\u30fb\u8a8d\u77e5\u3068\u3044\u3063\u305f\u9ad8\u6b21\u8133\u6a5f\u80fd\u3084\u795e\u7d4c\u4fdd\u8b77\u30fb\u93ae\u75db\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u6a5f\u80fd\u306b\u95a2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":467,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","footnotes":""},"class_list":["post-156","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=156"}],"version-history":[{"count":3,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/156\/revisions"}],"predecessor-version":[{"id":2581,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/156\/revisions\/2581"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/467"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}