{"id":186,"date":"2013-06-18T14:58:51","date_gmt":"2013-06-18T05:58:51","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=186"},"modified":"2015-01-20T11:27:42","modified_gmt":"2015-01-20T02:27:42","slug":"research02","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/history\/research02\/","title":{"rendered":"\u5fc3\u6a5f\u80fd\u5206\u6790\u306e\u305f\u3081\u306e\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a"},"content":{"rendered":"<h2>\u9759\u8108\u5185\u6295\u4e0e\u578bO-15\u6a19\u8b58O<sub>2<\/sub>\u5264\uff08Injectable [<sup>15<\/sup>O]O<sub>2<\/sub>\uff09\u306b\u3088\u308b\u30d6\u30bf\u5fc3\u7b4b\u9178\u7d20\u6442\u53d6\u7387\u306e\u6e2c\u5b9a<\/h2>\n<p>\u30e9\u30c3\u30c8\u8133\u9178\u7d20\u4ee3\u8b1d\u6e2c\u5b9a\u3092\u76ee\u7684\u3068\u3057\u3066\u958b\u767a\u3057\u305f\u9759\u8108\u5185\u6295\u4e0e\u578bO-15\u6a19\u8b58O<sub>2<\/sub>\u5264\uff08Injectable [<sup>15<\/sup>O]O2\uff09\u306b\u3064\u3044\u3066\u3001\u5468\u56f2\u9ad8\u653e\u5c04\u80fd\u306e\u5f71\u97ff\u3092\u30ad\u30e3\u30f3\u30bb\u30eb\u30a2\u30a6\u30c8\u3057\u3066\u5bfe\u8c61\u7d44\u7e54\u306e\u9178\u7d20\u4ee3\u8b1d\u3092\u8a55\u4fa1\u3067\u304d\u308b\u7279\u5fb4\u306b\u7740\u76ee\u3057\u3001[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u5438\u5165\u6cd5\u3067\u306f\u5468\u56f2\uff08\u80ba\uff09\u306b\u5b58\u5728\u3059\u308b\u9ad8\u3044\u653e\u5c04\u80fd\u304c\u89e3\u6790\u4e0a\u306e\u56f0\u96e3\u3055\u3092\u5897\u3059\u5fc3\u7b4b\u306b\u304a\u3051\u308b\u9178\u7d20\u4ee3\u8b1d\u6e2c\u5b9a\u3078\u306e\u5fdc\u7528\u3092\u691c\u8a0e\u3057\u305f\u3002<\/p>\n<p>\u52d5\u7269\u306b\u306f\u30df\u30cb\u30d6\u30bf\u3092\u7528\u3044\u3001Injectable [<sup>15<\/sup>O]O<sub>2<\/sub>\u3092\u6025\u901f\u975c\u6ce8\u3059\u308binjection\u6cd5\u3068\u3001\u5927\u817f\u52d5\u9759\u8108\u9593\u3092\u4eba\u5de5\u80ba\u3092\u4ecb\u3057\u3066\u63a5\u7d9a\u3057\u4eba\u5de5\u80ba\u3088\u308a\u6301\u7d9a\u7684\u306b[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u3092\u4f9b\u7d66\u3059\u308bcontinuous infusion\u6cd5\u3092\u65bd\u884c\u3057\u3066\u3001[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u5438\u5165\u6cd5\uff08continuous inhalation\u6cd5\uff09\u3068\u6bd4\u8f03\u691c\u8a0e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001injection\u6cd5\u3001continuous infusion\u6cd5\u3067\u306fcontinuous inhalation\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u80ba\u306b\u304a\u3051\u308b\u653e\u5c04\u80fd\u3092\u5927\u304d\u304f\u6e1b\u5f31\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u5fc3\u7b4b\u5074\u58c1\u306b\u304a\u3044\u3066\u540c\u7b49\u306e\u9178\u7d20\u6442\u53d6\u7387\uff08OEF)\u3092\u6e2c\u5b9a\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/p>\n<div id=\"attachment_166\" style=\"width: 624px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/pig_for_HP.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-166\" class=\" wp-image-166 \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/pig_for_HP.jpg\" alt=\"pig_for_HP\" width=\"614\" height=\"461\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/pig_for_HP.jpg 960w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/pig_for_HP-300x225.jpg 300w\" sizes=\"auto, (max-width: 614px) 100vw, 614px\" \/><\/a><p id=\"caption-attachment-166\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li>Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable <sup>15<\/sup>O-O<sub>2<\/sub>.<br \/>\nEur J Nucl Med Mol Imaging. 2010 Feb;37(2):377-85.<\/li>\n<\/ul>\n<h2>\u5fc3\u81d3\u4ea4\u611f\u795e\u7d4c\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u305f\u3081\u306e\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u306e\u958b\u767a<\/h2>\n<p>\u5fc3\u81d3\u4ea4\u611f\u795e\u7d4c\u306e\u795e\u7d4c\u7d42\u672b\u30d7\u30ec\u30b7\u30ca\u30d7\u30b9\u306b\u306f\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc (NET) \u304c\u5b58\u5728\u3057\u3001\u7a2e\u3005\u306e\u5fc3\u75be\u60a3\u306b\u304a\u3044\u3066\u3001\u3053\u306eNET\u306e\u767a\u73fe\u91cf\u306b\u5909\u5316\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001NET\u306e\u5909\u5316\u3092\u4f53\u5916\u304b\u3089\u691c\u51fa\u3059\u308b\u3053\u3068\u306f\u3001\u3053\u308c\u3089\u306e\u75c5\u614b\u306b\u95a2\u3059\u308b\u6709\u7528\u306a\u60c5\u5831\u3092\u4e0e\u3048\u3046\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u6211\u3005\u306f\u3053\u308c\u307e\u3067\u306b<a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/molecular-imaging\/research01\/#title2\" title=\"\u8133\u6a5f\u80fd\u5206\u6790\u306e\u305f\u3081\u306e\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\" class=\"liexternal\">\u8133\u5185NET\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u3068\u3057\u3066(S,S)-[<sup>123<\/sup>I]IPBM\u306e\u6709\u52b9\u6027\u3092\u660e\u3089\u304b\u3068\u3057\u3066\u3044\u308b<\/a>\u3053\u3068\u304b\u3089\u3001\u672c\u5316\u5408\u7269\u306e\u5fc3\u81d3NET\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u3068\u3057\u3066\u306e\u5fdc\u7528\u6027\u3092\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n<p>\u30a4\u30f3\u30d3\u30c8\u30ed\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001 (S,S)-IPBM\u306fNET\u306b\u7d50\u5408\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u6c4e\u7528\u3055\u308c\u3066\u3044\u308bnisoxetine\u3084\u6bcd\u4f53\u5316\u5408\u7269\u306ereboxetine\u3068\u307b\u307c\u540c\u7b49\u306e\u89aa\u548c\u6027\u3092\u6301\u3064\u3053\u3068\u3092\u8a8d\u3081\u305f\uff08\u56f3\uff12\uff09\u3002\u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u30a4\u30f3\u30d3\u30dc\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001 (S,S)-[<sup>125<\/sup>I]IPBM\u306f\u901f\u3084\u304b\u304b\u3064\u9ad8\u3044\u5fc3\u81d3\u3078\u306e\u53d6\u308a\u8fbc\u307f\u3092\u793a\u3057\u3001\u653e\u5c04\u80fd\u306e\u5fc3\u81d3\u8840\u6db2\u6bd4\u306f\u7d4c\u6642\u7684\u306b\u5897\u5927\u3057\u305f\uff08\u56f3\uff13\uff09\u3002\u3055\u3089\u306b\u5404\u30e2\u30ce\u30a2\u30df\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u7d50\u5408\u5264\u3092\u6295\u4e0e\u3057\u305f\u3068\u304d\u306e(S,S)-[<sup>125<\/sup>I]IPBM\u306e\u5fc3\u96c6\u7a4d\u3092\u8a55\u4fa1\u3057\u305f\u3068\u3053\u308d\u3001NET\u7d50\u5408\u5264\u3067\u3042\u308bnisoxetine\u3084desipramine\u306b\u3088\u3063\u3066\u306e\u307f\u96c6\u7a4d\u304c\u963b\u5bb3\u3055\u308c\u305f\u3053\u3068\u304b\u3089\u3001(S,S)-[<sup>125<\/sup>I]IPBM\u304c\u30a4\u30f3\u30d3\u30dc\u3067\u3082NET\u306b\u9078\u629e\u7684\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff08\u56f3\uff14\uff09\u3002<br \/>\n\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001(S,S)-[<sup>123<\/sup>I]IPBM\u304cNET\u3092\u6a19\u7684\u3068\u3057\u305f\u5fc3\u6a5f\u80fd\u8a3a\u65ad\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u3068\u3057\u3066\u6709\u7528\u306a\u6027\u8cea\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<div id=\"attachment_165\" style=\"width: 615px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/IPBM_for_Heart.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-165\" class=\" wp-image-165 \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/IPBM_for_Heart.jpg\" alt=\"IPBM_for_Heart\" width=\"605\" height=\"403\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/IPBM_for_Heart.jpg 1080w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/IPBM_for_Heart-300x200.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/IPBM_for_Heart-1024x682.jpg 1024w\" sizes=\"auto, (max-width: 605px) 100vw, 605px\" \/><\/a><p id=\"caption-attachment-165\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li>Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.<br \/>\nNucl Med Biol. 2008 Feb;35(2):213-8.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u9759\u8108\u5185\u6295\u4e0e\u578bO-15\u6a19\u8b58O2\u5264\uff08Injectable [15O]O2\uff09\u306b\u3088\u308b\u30d6\u30bf\u5fc3\u7b4b\u9178\u7d20\u6442\u53d6\u7387\u306e\u6e2c\u5b9a \u30e9\u30c3\u30c8\u8133\u9178\u7d20\u4ee3\u8b1d\u6e2c\u5b9a\u3092\u76ee\u7684\u3068\u3057\u3066\u958b\u767a\u3057\u305f\u9759\u8108\u5185\u6295\u4e0e\u578bO-15\u6a19\u8b58O2\u5264\uff08Injectable [15O]O2\uff09\u306b\u3064\u3044\u3066 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":467,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","footnotes":""},"class_list":["post-186","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=186"}],"version-history":[{"count":1,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/186\/revisions"}],"predecessor-version":[{"id":1674,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/186\/revisions\/1674"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/467"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}