{"id":218,"date":"2013-06-18T15:58:15","date_gmt":"2013-06-18T06:58:15","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=218"},"modified":"2014-10-29T13:13:00","modified_gmt":"2014-10-29T04:13:00","slug":"research05","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/history\/research05\/","title":{"rendered":"\u30a4\u30f3\u30d3\u30dc\u753b\u50cf\u89e3\u6790\u6cd5\u306b\u3088\u308b\u8133\u75c5\u614b\u306e\u89e3\u660e"},"content":{"rendered":"<h2>\u9759\u8108\u5185\u6ce8\u5c04\u7528O-15\u6a19\u8b58O<sub>2<\/sub>\u5264\uff08injectable [<sup>15<\/sup>O]O<sub>2<\/sub>\uff09\u306b\u3088\u308b\u30e9\u30c3\u30c8\u8133\u9178\u7d20\u4ee3\u8b1d\u7387\u306e\u6e2c\u5b9a<\/h2>\n<p>\u8133\u9178\u7d20\u6442\u53d6\u7387\uff08OEF\uff09\u3001\u8133\u9178\u7d20\u4ee3\u8b1d\u7387\uff08CMRO<sub>2<\/sub>\uff09\u6e2c\u5b9a\u306f\u8133\u5faa\u74b0\u969c\u5bb3\u306e\u8a55\u4fa1\u306b\u975e\u5e38\u306b\u6709\u7528\u3067\u3042\u308a\u3001\u81e8\u5e8a\u3067\u306fPET\u3092\u7528\u3044\u305f[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u5438\u5165\u6cd5\u306b\u3088\u308a\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u5c0f\u52d5\u7269\u3092\u7528\u3044\u305f\u57fa\u790e\u5b9f\u9a13\u3067\u306f\u5438\u5165\u30e9\u30a4\u30f3\u4e2d\u306e\u9ad8\u653e\u5c04\u80fd\u304c\u30a2\u30fc\u30c1\u30d5\u30a1\u30af\u30c8\u3068\u306a\u308b\u305f\u3081[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u5438\u5165\u6cd5\u306e\u9069\u7528\u306f\u975e\u5e38\u306b\u56f0\u96e3\u3067\u3042\u3063\u305f\u3002<\/p>\n<p>\u305d\u3053\u3067\u6211\u3005\u306f\u3001\u5468\u56f2\u9ad8\u653e\u5c04\u80fd\u306e\u5f71\u97ff\u3092\u53d7\u3051\u305a\u306b\u5c0f\u52d5\u7269\u3067\u306eOEF\u3001CMRO<sub>2<\/sub>\u6e2c\u5b9a\u3092\u53ef\u80fd\u3068\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u9759\u8108\u5185\u6ce8\u5c04\u7528O-15\u6a19\u8b58O<sub>2<\/sub>\u5264\uff08\u4ee5\u4e0binjectable [<sup>15<\/sup>O]O<sub>2<\/sub>\uff09\u3092\u958b\u767a\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001\u4eba\u5de5\u80ba\u3092\u4ecb\u3057\u3066\u8840\u6db2\uff08\u8840\u7403\uff09\u4e2d\u306b[<sup>15<\/sup>O]O<sub>2<\/sub>\u3092\u53d6\u308a\u8fbc\u307e\u305b\u308b\u3053\u3068\u3067\u3001\u5c0f\u52d5\u7269PET\u64ae\u50cf\u304c\u53ef\u80fd\u306a\u6bd4\u653e\u5c04\u80fd\u3092\u6709\u3059\u308b[<sup>15<\/sup>O]O<sub>2<\/sub>\u6a19\u8b58\u8840\u6db2\uff08injectable [<sup>15<\/sup>O]O<sub>2<\/sub>\uff09\u3092\u958b\u767a\u3057\u305f\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u306b\u3001\u672c\u5264\u3092\u6b63\u5e38\u30e9\u30c3\u30c8\u30fb\u4e2d\u5927\u8133\u52d5\u8108\u6c38\u4e45\u9589\u585e\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306b\u5c3e\u9759\u8108\u5185\u6295\u4e0e\u3057\u3001\u982d\u90e8PET\u64ae\u50cf\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u5c0f\u52d5\u7269\u306b\u304a\u3044\u3066\u3082OEF\u3001CMRO<sub>2<\/sub>\u306e\u5b9a\u91cf\u7684\u6e2c\u5b9a\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304d\u305f\uff08\u4e0b\u56f3\u30b9\u30e9\u30a4\u30c9\uff09\u3002\u3055\u3089\u306b\u6700\u8fd1\u3067\u306f\u81ea\u7136\u767a\u75c7\u9ad8\u8840\u5727\u30e9\u30c3\u30c8\uff08Spontaneously Hypertensive Rat, SHR\uff09\u3092\u7528\u3044\u3066injectable [<sup>15<\/sup>O]O<sub>2<\/sub> &#8211; PET\u64ae\u50cf\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9ad8\u8840\u5727\u304c\u8133\u5352\u4e2d\u767a\u75c7\u5f8c\u306e\u969c\u5bb3\u3092\u5897\u60aa\u3059\u308b\u53ef\u80fd\u6027\u3092\u898b\u51fa\u3057\u3066\u304d\u3066\u3044\u308b\u3002<\/p>\n<p>\u672c\u6cd5\u3092\u7528\u3044\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5f93\u6765\u4e0d\u53ef\u80fd\u3067\u3042\u3063\u305f\u5c0f\u52d5\u7269\u3067\u306eOEF\u3001CMRO<sub>2<\/sub>\u304c\u975e\u4fb5\u8972\u7684\u306b\u7e70\u308a\u8fd4\u3057\u5b9a\u91cf\u53ef\u80fd\u3068\u306a\u308b\u306e\u307f\u306a\u3089\u305a\u3001\u7121\u9ebb\u9154\u306e\u5927\u52d5\u7269\u5b9f\u9a13\u3067\u3082\u5438\u5165\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u305f\u3081\u3001\u8133\u5faa\u74b0\u969c\u5bb3\u306e\u57fa\u790e\u7684\u7814\u7a76\u306b\u975e\u5e38\u306b\u6709\u7528\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n<p>\u307e\u305f\u3001\u4e0a\u8ff0\u306e\u901a\u308a\u3001Injectable [<sup>15<\/sup>O]O<sub>2<\/sub>\u306f\u5468\u56f2\u9ad8\u653e\u5c04\u80fd\u306e\u5f71\u97ff\u3092\u6e1b\u305a\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u6700\u8fd1\u3001[<sup>15<\/sup>O]O<sub>2<\/sub>\u30ac\u30b9\u5438\u5165\u6cd5\u3067\u306f\u80ba\u4e2d\u306e\u9ad8\u3044\u653e\u5c04\u80fd\u304c\u554f\u984c\u3068\u306a\u308b<a href=\"research-2.html\" target=\"_blank\" class=\"liinternal\">\u5fc3\u7b4b\u306e\u9178\u7d20\u4ee3\u8b1d\u6e2c\u5b9a\u3078\u306e\u5fdc\u7528<\/a>\u3082\u8a66\u307f\u3001\u4e00\u5b9a\u306e\u6210\u679c\u3092\u6319\u3052\u3066\u3044\u308b\u3002<\/p>\n<div id=\"attachment_215\" style=\"width: 829px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/inj-O2-2.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-215\" class=\" wp-image-215   \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/inj-O2-2-1024x708.jpg\" alt=\"\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002\" width=\"819\" height=\"566\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/inj-O2-2-1024x708.jpg 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/inj-O2-2-300x207.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/inj-O2-2.jpg 1040w\" sizes=\"auto, (max-width: 819px) 100vw, 819px\" \/><\/a><p id=\"caption-attachment-215\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li>PET O-15 cerebral blood flow and metabolism after acute stroke in spontaneously hypertensive rats.<br \/>\nBrain Res. 2008, 1212, 18-24.<\/li>\n<li>Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable 15O-O2<br \/>\nJ Cereb Blood Flow Metab. 2006, 26(12):1577-1583.<\/li>\n<li>Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats.<br \/>\nNucl Med Biol. 2004, 31(6):811-4.<\/li>\n<li>Development of injectable O-15 oxygen and estimation of rat OEF.<br \/>\nJ Cereb Blood Flow Metab. 2003, 23(6):671-6.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u9759\u8108\u5185\u6ce8\u5c04\u7528O-15\u6a19\u8b58O2\u5264\uff08injectable [15O]O2\uff09\u306b\u3088\u308b\u30e9\u30c3\u30c8\u8133\u9178\u7d20\u4ee3\u8b1d\u7387\u306e\u6e2c\u5b9a \u8133\u9178\u7d20\u6442\u53d6\u7387\uff08OEF\uff09\u3001\u8133\u9178\u7d20\u4ee3\u8b1d\u7387\uff08CMRO2\uff09\u6e2c\u5b9a\u306f\u8133\u5faa\u74b0\u969c\u5bb3\u306e\u8a55\u4fa1\u306b\u975e\u5e38\u306b\u6709\u7528\u3067\u3042\u308a\u3001\u81e8\u5e8a\u3067\u306fPET\u3092\u7528\u3044\u305f[1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":467,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=218"}],"version-history":[{"count":2,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/218\/revisions"}],"predecessor-version":[{"id":1600,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/218\/revisions\/1600"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/467"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}