{"id":224,"date":"2013-06-18T16:27:32","date_gmt":"2013-06-18T07:27:32","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=224"},"modified":"2015-06-05T18:12:54","modified_gmt":"2015-06-05T09:12:54","slug":"research07","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/kinouseigazoushindanyaku\/research07\/","title":{"rendered":"\u52d5\u8108\u786c\u5316\u75c5\u614b\u306e\u75c5\u614b\u89e3\u6790"},"content":{"rendered":"<h2>\u7d30\u80de\u819c\u4e0a\u306b\u767a\u73fe\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\uff08LOX-1\u3001MT1-MMP\u3001TF\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u52d5\u8108\u786c\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/h2>\n<p>In vitro\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001\u9178\u5316LDL\u53d7\u5bb9\u4f53\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u3064\u3067\u3042\u308bLectin-like oxidized LDL receptor-1 (LOX-1)\u306f<a href=\"#plaque\" title=\"\u8840\u7ba1\u5185\u4e0d\u5b89\u5b9a\u30d7\u30e9\u30fc\u30af\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\" class=\"liinternal\">\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af<\/a>\u306e\u4e0d\u5b89\u5b9a\u5316\u306b\u591a\u9762\u7684\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u4e0d\u5b89\u5b9a\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u6a19\u7684\u3068\u3057\u3066LOX-1\u306b\u7740\u76ee\u3057\u3001\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u3092\u7528\u3044\u3066\u4e0d\u5b89\u5b9a\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u90e8\u4f4d\u3067\u306eLOX-1\u306e\u767a\u73fe\u72b6\u614b\u3092\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u7684\u624b\u6cd5\u306b\u3088\u308a\u691c\u8a0e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001LOX-1\u306e\u767a\u73fe\u306f\u3001MMP-9\u306e\u767a\u73fe\u3001\u304a\u3088\u3073\u3001\u30d7\u30e9\u30fc\u30af\u306e\u4e0d\u5b89\u5b9a\u6027\u306e\u6307\u6a19\u3068\u9ad8\u3044\u76f8\u95a2\u3092\u793a\u3059\u3068\u3068\u3082\u306b\u3001\u7dda\u7dad\u6027\u88ab\u819c\u306e\u8584\u3044\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306f\u539a\u3044\u3082\u306e\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u9ad8\u3044LOX-1\u767a\u73fe\u3092\u8a8d\u3081\u305f\u3002\u3055\u3089\u306b\u3001LOX-1\u306f\u3001\u8840\u6813\u5f62\u6210\u306e\u539f\u56e0\u3068\u306a\u308b\u7d44\u7e54\u56e0\u5b50\u3068\u5171\u5c40\u5728\u3092\u793a\u3057\u305f\u3053\u3068\u304b\u3089\u3001LOX-1\u304c\u4e0d\u5b89\u5b9a\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u305f\u3081\u306e\u6a19\u7684\u5206\u5b50\u3068\u3057\u3066\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<p>\u305d\u3053\u3067\u3001LOX-1\u3092\u6a19\u7684\u3068\u3059\u308b\u653e\u5c04\u6027\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\u3092\u8a08\u753b\u3057\u305f\u3002\u6bcd\u4f53\u5206\u5b50\u3068\u3057\u3066\u306f\u6297LOX-1\u6297\u4f53\u3001\u653e\u5c04\u6027\u6838\u7a2e\u3068\u3057\u3066\u306f<sup>99m<\/sup>Tc\u3092\u305d\u308c\u305e\u308c\u9078\u629e\u3057\u3001\u4e8c\u5b98\u80fd\u6027\u30ad\u30ec\u30fc\u30c8\u5206\u5b50\u306e\u6982\u5ff5\u306e\u5143\u306b<sup>99m<\/sup>Tc\u6a19\u8b58\u6297LOX-1\u6297\u4f53\u3092\u8a2d\u8a08\u3001\u5408\u6210\u3057\u305f\uff08\u56f3\uff11\uff09\u3002\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u3092\u7528\u3044\u305f\u691c\u8a0e\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001<sup>99m<\/sup>Tc\u6a19\u8b58\u6297LOX-1\u6297\u4f53\u6295\u4e0e24\u6642\u9593\u5f8c\u306e\u5927\u52d5\u8108\u3078\u306e\u96c6\u7a4d\u306f\u3001\u6b63\u5e38\u30a6\u30b5\u30ae\u306b\u6bd4\u3079\u3066\u7d0410\u500d\u9ad8\u304f\uff08\u56f3\uff12\uff09\u3001SPECT\u3092\u7528\u3044\u305f\u660e\u77ad\u306a\u5927\u52d5\u8108\u306e\u63cf\u51fa\u306b\u6210\u529f\u3057\u305f\uff08\u56f3\uff13\uff09\u3002\u3055\u3089\u306b\u3001\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u5927\u52d5\u8108\u306b\u3064\u3044\u3066\u7d44\u7e54\u5b66\u7684\u691c\u8a0e\u3092\u52a0\u3048\u305f\u3068\u3053\u308d\u3001<sup>99m<\/sup>Tc\u6a19\u8b58\u6297LOX-1\u6297\u4f53\u306fLOX-1\u306e\u767a\u73fe\u306b\u5fdc\u3058\u305f\u5206\u5e03\u3092\u793a\u3059\uff08\u56f3\uff14\uff09\u3068\u3068\u3082\u306b\u3001\u4e0d\u5b89\u5b9a\u6027\u3092\u793a\u3059\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u75c5\u5909\u306b\u304a\u3044\u3066\u6700\u3082\u9ad8\u3044\u653e\u5c04\u80fd\u96c6\u7a4d\u3092\u793a\u3057\u305f\u3002<\/p>\n<p>\u4ee5\u4e0a\u3088\u308a\u3001<sup>99m<\/sup>Tc\u6a19\u8b58\u6297LOX-1\u6297\u4f53\u306f\u4e0d\u5b89\u5b9a\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u6838\u533b\u5b66\u8cea\u7684\u8a3a\u65ad\u306b\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<div id=\"attachment_228\" style=\"width: 682px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/LOX-1.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-228\" class=\" wp-image-228   \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/LOX-1.jpg\" alt=\"LOX-1\" width=\"672\" height=\"504\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/LOX-1.jpg 960w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/LOX-1-300x225.jpg 300w\" sizes=\"auto, (max-width: 672px) 100vw, 672px\" \/><\/a><p id=\"caption-attachment-228\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<p id=\"mt1\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/research07\/#plaque\" title=\"\u8840\u7ba1\u5185\u4e0d\u5b89\u5b9a\u30d7\u30e9\u30fc\u30af\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\" class=\"liexternal\">\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af<\/a>\u306e\u4e0d\u5b89\u5b9a\u5316\u306e\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08MMP\uff09\u306b\u3088\u308a\u30d7\u30e9\u30fc\u30af\u3092\u8986\u3046\u7dda\u7dad\u6027\u88ab\u819c\u304c\u8106\u5f31\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u306eMMP\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u3064\u3067\u3042\u308b\u7d30\u80de\u819c\u7d50\u5408\u578bMMP\uff08MT1-MMP\uff09\u306f\u3001\u30d7\u30e9\u30fc\u30af\u306e\u4e0d\u5b89\u5b9a\u5316\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u308bMMP-2\u3092\u7d30\u80de\u819c\u4e0a\u3067\u6d3b\u6027\u5316\u3059\u308b\u9175\u7d20\u3067\u3042\u308b\u3002\u6700\u8fd1\u3001\u30d2\u30c8\u306e\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306b\u304a\u3044\u3066\u3053\u306eMT1-MMP\u306e\u767a\u73fe\u304c\u8a8d\u3081\u3089\u308c\u305f\u3053\u3068\u304b\u3089\u3001MT1-MMP\u304c\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u4e0d\u5b89\u5b9a\u5316\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\u305d\u3053\u3067\u6211\u3005\u306f\u3001\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306b\u304a\u3051\u308bMT1-MMP\u306e\u767a\u73fe\u3068\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u4e0d\u5b89\u5b9a\u6027\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u3001\u6b21\u3044\u3067\u3001MT1-MMP\u3092\u6a19\u7684\u3068\u3057\u305f\u653e\u5c04\u6027\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\u306b\u7740\u624b\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001MT1-MMP\u767a\u73fe\u5bc6\u5ea6\u306f\u6700\u3082\u4e0d\u5b89\u5b9a\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u75c5\u5909\u306b\u304a\u3044\u3066\u7279\u7570\u7684\u306b\u9ad8\u304f\u8a8d\u3081\u3089\u308c\u3001MT1-MMP\u306f\u4e0d\u5b89\u5b9a\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u6a19\u7684\u3068\u3057\u3066\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u653e\u5c04\u6027\u85ac\u5264\u306e\u6bcd\u4f53\u5206\u5b50\u3068\u3057\u3066\u306f\u6297MT1-MMP\u6297\u4f53\u3092\u9078\u629e\u3057\u3001<sup>99m<\/sup>Tc\u6a19\u8b58\u6297LOX-1\u6297\u4f53\u3068\u540c\u69d8\u306e\u624b\u6cd5\u306b\u57fa\u3065\u304d<sup>99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u3092\u8a2d\u8a08\u30fb\u5408\u6210\u3057\u305f\u3002\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u3092\u7528\u3044\u305f\u691c\u8a0e\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001<sup>99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u306f\u6b63\u5e38\u30a6\u30b5\u30ae\u3068\u6bd4\u3057\u3066\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u5927\u52d5\u8108\u306b\u7d045.4\u500d\u9ad8\u304f\u96c6\u7a4d\u3057\u3001SPECT\u306b\u3088\u308b\u660e\u77ad\u306a\u5927\u52d5\u8108\u306e\u63cf\u51fa\u306b\u6210\u529f\u3057\u305f\u3002\u7d44\u7e54\u5b66\u7684\u691c\u8a0e\u306b\u3088\u308a\u3001<sup>99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u306fMT1-MMP\u767a\u73fe\u306b\u5fdc\u3058\u305f\u5206\u5e03\u3092\u793a\u3057\u3001\u4e0d\u5b89\u5b9a\u6027\u75c5\u5909\u306b\u7279\u7570\u7684\u306b\u96c6\u7a4d\u3057\u305f\u3053\u3068\u304b\u3089\u3001<sup>99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u306b\u3088\u308a\u4e0d\u5b89\u5b9a\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u3092\u9078\u629e\u7684\u306b\u691c\u51fa\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<p>\u307e\u305f\u3001MT1-MMP\u306f\u304c\u3093\u306e\u6d78\u6f64\u30fb\u8ee2\u79fb\u306b\u5bc6\u63a5\u306b\u95a2\u4e0e\u3057\u304c\u3093\u306e\u60aa\u6027\u5ea6\u3068\u306e\u76f8\u95a2\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u6211\u3005\u306f<a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/molecular-imaging\/research08\/#mt1\" title=\"\u304c\u3093\u306e\u75c5\u614b\u5206\u6790\u304b\u3089\u6cbb\u7642\u306b\u5411\u3051\u3066\" target=\"_blank\" class=\"liexternal\"><sup>99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u3092\u7528\u3044\u305f\u304c\u3093\u306e\u30a4\u30f3\u30d3\u30dc\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u95a2\u3059\u308b\u691c\u8a0e<\/a>\u3082\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7d44\u7e54\u56e0\u5b50\uff08Tissue Factor, TF\uff09\u306f\u5916\u56e0\u6027\u8840\u6db2\u51dd\u56fa\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u958b\u59cb\u56e0\u5b50\u3067\u3042\u308a\u3001\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u7834\u7dbb\u306b\u4f34\u3046\u8840\u6813\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u3059\u306a\u308f\u3061\u3001\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u4e0d\u5b89\u5b9a\u5316\u306b\u4f34\u3063\u3066\u30d7\u30e9\u30fc\u30af\u5185\u90e8\u306b\u767a\u73fe\u306e\u5897\u52a0\u3057\u305fTF\u304c\u3001\u30d7\u30e9\u30fc\u30af\u7834\u7dbb\u306b\u3088\u308a\u8840\u6db2\u4e2d\u306e\u7b2cVIIa\u56e0\u5b50\u3068\u63a5\u89e6\u30fb\u53cd\u5fdc\u3059\u308b\u3053\u3068\u3067\u8840\u6db2\u51dd\u56fa\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u958b\u59cb\u3057\u3001\u8840\u6813\u306e\u5f62\u6210\u306b\u81f3\u308b\u3002\u5f53\u7814\u7a76\u5ba4\u306b\u304a\u3044\u3066\u3082\u3053\u308c\u307e\u3067\u306b\u3001\u52d5\u8108\u786c\u5316\u30e2\u30c7\u30eb\u30a6\u30b5\u30ae\u3092\u7528\u3044\u305f\u7d44\u7e54\u5b66\u7684\u691c\u8a0e\u3092\u884c\u3044\u3001TF\u306e\u767a\u73fe\u304c\u4e0d\u5b89\u5b9a\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u75c5\u5909\u306b\u9078\u629e\u7684\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304d\u305f\u3002<\/p>\n<p>\u305d\u3053\u3067\u6211\u3005\u306f\u3001TF\u3092\u6a19\u7684\u3068\u3057\u305f\u653e\u5c04\u6027\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3092\u8a08\u753b\u3057\u305f\u3002\u30d7\u30ed\u30fc\u30d6\u306e\u6bcd\u4f53\u5206\u5b50\u306b\u306f\u3053\u308c\u307e\u3067\u540c\u69d8\u6297TF\u6297\u4f53\u306e\u5229\u7528\u3092\u8003\u3048\u3001TF\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u306b\u3064\u3044\u3066\u30da\u30d7\u30c1\u30c9\u6297\u539f\u6027\u30b5\u30fc\u30c1\u3092\u884c\u3063\u305f\u5f8c\u3001\u9078\u629e\u3057\u305f\u914d\u5217\u3092\u30a8\u30d4\u30c8\u30fc\u30d7\u3068\u3057\u305f\u6297TF\u30de\u30a6\u30b9\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3092\u5f97\u305f\u3002\u4e0a\u8a18\u3068\u540c\u69d8\u306e\u65b9\u6cd5\u306b\u3088\u308a<sup>99m<\/sup>Tc\u6a19\u8b58\u6297TF\u6297\u4f53\u3092\u8a2d\u8a08\u30fb\u5408\u6210\u3057\u3001\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u3092\u7528\u3044\u305f\u691c\u8a0e\u3092\u884c\u3063\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u6240\u671f\u306e\u3068\u304a\u308a<sup>99m<\/sup>Tc\u6a19\u8b58\u6297TF\u6297\u4f53\u306f\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u5927\u52d5\u8108\u306b\u9ad8\u304f\u96c6\u7a4d\u3057\u3001TF\u767a\u73fe\u306b\u5fdc\u3058\u305f\u5206\u5e03\u3092\u793a\u3057\u305f\u3053\u3068\u304b\u3089\u3001<sup>99m<\/sup>Tc\u6a19\u8b58\u6297TF\u6297\u4f53\u306b\u3088\u308a\u9078\u629e\u7684\u306b\u4e0d\u5b89\u5b9a\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u3092\u63cf\u51fa\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002<\/p>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li>Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic model rabbit.<br \/>\n<em>J. Nucl. Med.<\/em> <strong>51<\/strong> (12) 1979-1986 (2010)<\/li>\n<li>Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques.<br \/>\n<em>Eur. J. Nucl. Med. Mol. Imaging<\/em>\u00a0<strong>37<\/strong> (11) 2093-2104 (2010)<\/li>\n<li>Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with <sup>99m<\/sup>Tc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque.<br \/>\n<em>J. Nucl. Med.<\/em> <strong>49<\/strong> (10) 1677-1685 (2008)<\/li>\n<li>Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability&#8211;analysis in hypercholesterolemic rabbits.<br \/>\n<em><abbr title=\"Atherosclerosis\">Atherosclerosis<\/abbr><\/em>\u00a0<strong>195<\/strong> (1) 48-56 (2007)<\/li>\n<\/ul>\n<h2>\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u6a19\u7684\u3068\u3057\u305f\u52d5\u8108\u786c\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/h2>\n<p>\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306f\u3001<a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/research07\/#plaque\" title=\"\u8840\u7ba1\u5185\u4e0d\u5b89\u5b9a\u30d7\u30e9\u30fc\u30af\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\" class=\"liexternal\">\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af<\/a>\u306b\u304a\u3044\u3066\u3001\u8102\u8cea\u30b3\u30a2\u306e\u5897\u5927\u3084\u7dda\u7dad\u6027\u88ab\u819c\u306e\u8106\u5f31\u5316\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u308a\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u4e0d\u5b89\u5b9a\u6027\u3092\u8a55\u4fa1\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u4e00\u65b9\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5264\u3067\u3042\u308bTc-99m\u6a19\u8b58Annexin A5(<sup>99m<\/sup>Tc-annexin A5)\u306f\u3001\u52d5\u8108\u786c\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3078\u306e\u5fdc\u7528\u3082\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u6211\u3005\u306f\u3001\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u3092\u7528\u3044\u3066\u3001<sup>99m<\/sup>Tc-annexin A5\u306e\u52d5\u8108\u786c\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3078\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001<sup>99m<\/sup>Tc-annexin A5\u6295\u4e0e3\u6642\u9593\u5f8c\u306e\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u5927\u52d5\u8108\u3078\u306e\u96c6\u7a4d\u306f\u3001\u6b63\u5e38\u30a6\u30b5\u30ae\u306b\u6bd4\u3079\u30665.6\u500d\u9ad8\u304f\u3001SPECT\u3092\u7528\u3044\u305f\u5927\u52d5\u8108\u306e\u63cf\u51fa\u306b\u3082\u6210\u529f\u3057\u305f(\u56f31)\u3002\u305d\u3053\u3067\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u306e\u5927\u52d5\u8108\u306b\u3064\u3044\u3066\u7d44\u7e54\u5b66\u7684\u691c\u8a0e\u3092\u52a0\u3048\u305f\u3068\u3053\u308d\u3001<sup>99m<\/sup>Tc-annexin A5\u306e\u96c6\u7a4d\u306f\u3001\u4e0d\u5b89\u5b9a\u306a\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u3092\u542b\u3080\u75c5\u5909\u3067\u6700\u3082\u9ad8\u3044\u5024\u3092\u793a\u3057\u305f(\u56f32)\u3002\u3055\u3089\u306b\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u3067\u306f\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u7d30\u80de\u3092\u793a\u3059TUNEL\u967d\u6027\u7d30\u80de\u304c\u8a8d\u3081\u3089\u308c(\u56f33)\u3001<sup>99m<\/sup>Tc-annexin A5\u306e\u96c6\u7a4d\u306fTUNEL\u967d\u6027\u7d30\u80de\u306e\u5bc6\u5ea6\u3068\u6709\u610f\u306a\u76f8\u95a2\u3092\u793a\u3057\u305f(\u56f34)\u3002<\/p>\n<p>\u3057\u305f\u304c\u3063\u3066<sup>99m<\/sup>Tc-annexin A5\u3092\u7528\u3044\u3066\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u884c\u3046\u3053\u3068\u306b\u3088\u308a\u3001\u4e0d\u5b89\u5b9a\u306a\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u3092\u9078\u629e\u7684\u306b\u691c\u51fa\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_226\" style=\"width: 682px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/Annexin2.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-226\" class=\" wp-image-226    \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/Annexin2.jpg\" alt=\"\u56f31\u3001\u56f32\u3001\u56f33\" width=\"672\" height=\"504\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/Annexin2.jpg 960w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/Annexin2-300x225.jpg 300w\" sizes=\"auto, (max-width: 672px) 100vw, 672px\" \/><\/a><p id=\"caption-attachment-226\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li><sup style=\"font-family: helvetica\">99m<\/sup>Tc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits.<\/li>\n<\/ul>\n<p><em>Eur. J. Nucl. Med. Mol. Imaging<\/em> <strong>34<\/strong> (6) 889-899 (2007)<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"plaque\">\u8840\u7ba1\u5185\u4e0d\u5b89\u5b9a\u30d7\u30e9\u30fc\u30af\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/h2>\n<p>\u52d5\u8108\u786c\u5316\u75c5\u5de3\u306b\u8a8d\u3081\u3089\u308c\u308b\u30d7\u30e9\u30fc\u30af\u306b\u306f\u3001\u7834\u7dbb\u3057\u306b\u304f\u3044\u5b89\u5b9a\u306a\u3082\u306e\u3068\u3001\u7834\u7dbb\u3057\u3084\u3059\u3044\u4e0d\u5b89\u5b9a\u306a\u3082\u306e\u3068\u304c\u5b58\u5728\u3059\u308b\uff08\u56f31\uff09\u3002\u4e0d\u5b89\u5b9a\u30d7\u30e9\u30fc\u30af\u306f\u3001\u30d7\u30e9\u30fc\u30af\u306e\u7834\u7dbb\u3001\u8840\u6813\u5f62\u6210\u3001\u8840\u7ba1\u5185\u8154\u306e\u72ed\u7a84\u30fb\u9589\u585e\u3068\u3044\u3046\u4e00\u9023\u306e\u75c5\u614b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8133\u6897\u585e\u3084\u5fc3\u7b4b\u6897\u585e\u306e\u539f\u56e0\u3068\u306a\u308b\u3002\u4e00\u65b9\u3001\u52d5\u8108\u786c\u5316\u75c5\u5909\u304c\u9032\u884c\u3057\u3066\u3082\u5b89\u5b9a\u30d7\u30e9\u30fc\u30af\u3067\u3042\u308c\u3070\u3053\u306e\u3088\u3046\u306a\u75c5\u614b\u3092\u751f\u3058\u308b\u53ef\u80fd\u6027\u306f\u5c11\u306a\u3044\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u4e0d\u5b89\u5b9a\u30d7\u30e9\u30fc\u30af\u3092\u7279\u7570\u7684\u306b\u691c\u51fa\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6897\u585e\u6027\u75be\u60a3\u767a\u75c7\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u308c\u3070\u3001\u9069\u5207\u306a\u4e88\u9632\u7684\u6cbb\u7642\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308b\u3002<\/p>\n<p>PET\u7528\u7cd6\u4ee3\u8b1d\u80fd\u6e2c\u5b9a\u85ac\u5264\u3067\u3042\u308b<sup>18<\/sup>F-\u30d5\u30eb\u30aa\u30ed\u30c7\u30aa\u30ad\u30b7\u30b0\u30eb\u30b3\u30fc\u30b9([<sup>18<\/sup>F]FDG)\u306b\u3088\u308a\u4e0d\u5b89\u5b9a\u306a\u30d7\u30e9\u30fc\u30af\u3092\u5b89\u5b9a\u306a\u30d7\u30e9\u30fc\u30af\u3068\u533a\u5225\u3057\u9078\u629e\u7684\u306b\u6349\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u691c\u8a0e\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001[<sup>18<\/sup>F]FDG\u306e\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u5927\u52d5\u8108\u3078\u306e\u53d6\u308a\u8fbc\u307f\u91cf\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6570\u306e\u9593\u306b\u306f\u826f\u3044\u76f8\u95a2\u95a2\u4fc2\u304c\u8a8d\u3081\u3089\u308c\u305f\uff08\u56f32\uff09\u3002\u3064\u307e\u308a\u3001\u30d7\u30e9\u30fc\u30af\u3078\u306e[<sup>18<\/sup>F]FDG\u306e\u53d6\u308a\u8fbc\u307f\u306b\u306f\u3001\u30d7\u30e9\u30fc\u30af\u4e0d\u5b89\u5b9a\u5316\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6d78\u6f64\u304c\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u3002\u3055\u3089\u306b\u3001CT\u304a\u3088\u3073PET\u64ae\u50cf\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u52d5\u8108\u786c\u5316\u30a6\u30b5\u30ae\u3067\u306f\u52d5\u8108\u786c\u5316\u90e8\u4f4d\u306b\u9ad8\u304f\u653e\u5c04\u80fd\u304c\u96c6\u7a4d\u3057\u3001[<sup>18<\/sup>F]FDG\u306b\u3088\u308b\u30d7\u30e9\u30fc\u30af\u306e\u63cf\u51fa\u306b\u6210\u529f\u3057\u305f\uff08\u56f33\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001[<sup>18<\/sup>F]FDG-PET\u306b\u3088\u308c\u3070\u52d5\u8108\u786c\u5316\u90e8\u4f4d\u306b\u304a\u3044\u3066\u30d7\u30e9\u30fc\u30af\u306e\u8cea\u7684\u306a\u9055\u3044\u3092\u6349\u3048\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u4e0d\u5b89\u5b9a\u30d7\u30e9\u30fc\u30af\u3092\u9078\u629e\u7684\u306b\u753b\u50cf\u5316\u3067\u304d\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u305f\u3002<\/p>\n<div id=\"attachment_225\" style=\"width: 658px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/Plaque.jpg\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-225\" class=\" wp-image-225  \" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-content\/blogs.dir\/2\/files\/2013\/06\/Plaque.jpg\" alt=\"\u56f31\u3001\u56f32\u3001\u56f33\" width=\"648\" height=\"432\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/Plaque.jpg 810w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2013\/06\/Plaque-300x200.jpg 300w\" sizes=\"auto, (max-width: 648px) 100vw, 648px\" \/><\/a><p id=\"caption-attachment-225\" class=\"wp-caption-text\">\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li>Application of <sup>18<\/sup>F-FDG PET for Monitoring the Therapeutic Effect of Antiinflammatory Drugs on Stabilization of Vulnerable Atherosclerotic Plaques.<br \/>\n<em>J. Nucl. Med.<\/em> <strong>47<\/strong> (11) 1845-1850 (2006)<\/li>\n<li><sup>18<\/sup>F-FDG Accumulation in Atherosclerotic Plaques: Immunohistochemical andPET Imaging Study.<br \/>\n<em>J. Nucl. Med.<\/em> <strong>45<\/strong> (7) 1245-1250 (2004)<\/li>\n<li>A catheter-based radiation detector for endovascular detection of atheromatous plaques.<br \/>\nEur. J. Nucl. Med. Mol. Imaging <strong>31<\/strong> (9) 1299-1303 (2004)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7d30\u80de\u819c\u4e0a\u306b\u767a\u73fe\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\uff08LOX-1\u3001MT1-MMP\u3001TF\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u52d5\u8108\u786c\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0 In vitro\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001\u9178\u5316LDL\u53d7\u5bb9\u4f53\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u3064\u3067\u3042\u308bLectin-like oxidized LDL r [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":135,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-224","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=224"}],"version-history":[{"count":2,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/224\/revisions"}],"predecessor-version":[{"id":1768,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/224\/revisions\/1768"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/135"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}