{"id":2308,"date":"2018-08-11T13:10:53","date_gmt":"2018-08-11T04:10:53","guid":{"rendered":"http:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/?page_id=2308"},"modified":"2018-08-11T13:10:53","modified_gmt":"2018-08-11T04:10:53","slug":"%e4%bd%8e%e9%85%b8%e7%b4%a0%e8%aa%98%e5%b0%8e%e5%9b%a0%e5%ad%90%e5%ad%98%e5%9c%a8%e9%a0%98%e5%9f%9f%e3%82%92%e6%a4%9c%e5%87%ba%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ae%e6%94%be%e5%b0%84%e6%80%a7","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/%e4%bd%8e%e9%85%b8%e7%b4%a0%e8%aa%98%e5%b0%8e%e5%9b%a0%e5%ad%90%e5%ad%98%e5%9c%a8%e9%a0%98%e5%9f%9f%e3%82%92%e6%a4%9c%e5%87%ba%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ae%e6%94%be%e5%b0%84%e6%80%a7\/","title":{"rendered":"\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50\u5b58\u5728\u9818\u57df\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u653e\u5c04\u6027\u30d7\u30ed\u30fc\u30d6\u958b\u767a"},"content":{"rendered":"

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\u3053\u306e\u6982\u5ff5\u306b\u57fa\u3065\u304d\u3001\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u30d7\u30ed\u30fc\u30d6123<\/sup>I-IPOS\u3092\u958b\u767a\u3057\u3066\u305d\u306e\u8a55\u4fa1\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u6240\u671f\u306e\u901a\u308aHIF-1\u03b1\u306e\u5b58\u5728\u3059\u308b\u6761\u4ef6\u4e0b\u3067\u306e\u307f\u5b89\u5b9a\u306b\u5b58\u5728\u3057\u3001\u901a\u5e38\u9178\u7d20\u6761\u4ef6\u4e0b\u3067\u306f\u30d7\u30ed\u30fc\u30d6\u5168\u4f53\u304c\u5206\u89e3\u3055\u308c\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3067\u304d\u305f\u3002\u3055\u3089\u306b123<\/sup>I-IPOS\u306f\u30a4\u30f3\u30d3\u30dc\u3067\u816b\u760d\u96c6\u7a4d\u6027\u3092\u793a\u3057\u3001\u305d\u306e\u816b\u760d\u5185\u5206\u5e03\u306fHIF-1\u03b1\u5b58\u5728\u9818\u57df\u306b\u4e00\u81f4\u3059\u308b\u3053\u3068\u3092\u8a8d\u3081\u305f\u3002<\/p>\n

\"HIF1\"<\/a>

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\"HIF1-2\"<\/a>

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\u4e3b\u8981\u8ad6\u6587<\/h3>\n
    \n
  • Development of an Oxygen-Sensitive Degradable Peptide Probe for the Imaging of Hypoxia-Inducible Factor-1-Active Regions in Tumors
    \nMol. Imaging Biol.<\/em>\u00a015<\/strong>\u00a0(6) 713-721 (2013)<\/span><\/li>\n
  • Evaluation of [125<\/sup>I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor: Comparison among single-photon emission computed tomography\/X-ray computed tomography imaging, autoradiography, and immunohistochemistry.
    \nCancer Sci.<\/em>\u00a0102<\/strong>\u00a0(11) 2090-2096 (2011)<\/span><\/li>\n
  • PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel 18<\/sup>F-labeled biotin derivative.
    \nMol. Imaging Biol.<\/em>\u00a013<\/strong>\u00a0(5) 1003-1010 (2011)<\/span><\/li>\n
  • Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha.
    \nEur. J. Nucl. Med. Mol. Imaging<\/em>\u00a037<\/strong>\u00a0(8) 1566-1574 (2010)<\/span><\/li>\n
  • Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells.
    \nJ. Nucl. Med.<\/em>\u00a050<\/strong>\u00a0(6) 942-949 (2009)<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

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