{"id":2562,"date":"2020-01-18T10:45:54","date_gmt":"2020-01-18T01:45:54","guid":{"rendered":"http:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/?page_id=2562"},"modified":"2020-01-18T10:50:13","modified_gmt":"2020-01-18T01:50:13","slug":"2015-2","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/2015-2\/","title":{"rendered":"2015"},"content":{"rendered":"

2015 (\u8ad6\u6587)<\/h2>\n
    \n
  1. Kondo N, Temma T, Deguchi J, Sano K, Ono M, Saji H.
    \nDevelopment of PEGylated peptide probes conjugated with 18<\/sup>F-labeled BODIPY for PET\/optical imaging of MT1-MMP activity<\/span>
    \nJ. Control. Release <\/em>220 476-483 (2015)<\/span><\/li>\n
  2. Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M.
    \nCharacterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits<\/span>
    \nSci. Rep. <\/em>5 18440 (2015)<\/span><\/li>\n
  3. Ueda<\/span>\u00a0M,\u00a0Yamagami D, Watanabe K, Mori A, Kimura H, Sano K, Saji H, Ishikawa K, Hori M, Sakakita H, Ikehara Y, Enomoto S.
    \nHistological and Nuclear Medical Comparison of Inflammation After Hemostasis with Non-Thermal Plasma and Thermal Coagulation<\/span>
    \nPlasma Process. Polym. <\/em>12(12) 1338-1342 (2015)<\/span><\/li>\n
  4. Watanabe H, Ono M, Saji H.
    \n<\/span>In Vivo Fluorescence Imaging of \u03b2-Amyloid Plaques with Push-Pull Dimethylaminothiophene Derivatives
    \nChem. Commun.\u00a0<\/em>51(96) 17124-17127 (2015)<\/li>\n
  5. Matsumura K, Ono M, Kitada A, Watanabe H, Yoshimura M, Iikuni S, Kimura H, Okamoto Y, Ihara M, Saji H.
    \nStructure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents that Selectively Detect Neurofibrillary Tangles in Alzheimer\u2019s Disease Brains
    \nJ. Med. Chem.\u00a0<\/em>58(18) 7241-7257 (2015)<\/li>\n
  6. Onoe S, Temma T, Kana<\/span>zaki K, Ono M, Saji H.
    \n<\/span>Development of photostabilized asymmetrical cyanine dyes for in vivo photoacoustic imaging of tumors
    \nJ. Biomed. Opt.<\/em>\u00a0<\/em>20(9) 096006 (2015)<\/li>\n
  7. Kondo N, Temma T, Shimizu Y, Ono M, Saj H.
    \n<\/span>Radioiodinated peptidic imaging probes for in vivo detection of Membrane Type-1 Matrix Metalloproteinase in cancers
    \nBiol. Pharm. Bull.\u00a0<\/em>38(9) 1375-1382 (2015)<\/li>\n
  8. Kanazaki K, Sano K, Makino A, Shimizu Y, Yamauchi F, Ogawa S, Ding N, Yano T, Temma T, Ono M, Saji H.
    \n<\/span>Development of Anti-HER2 Fragment Antibody Conjugated to Iron Oxide Nanoparticles for in vivo HER2-Targeted Photoacoustic Tumor Imaging
    \nNanomedicine: NBM\u00a0<\/em>11(8) 2051-2060 (2015)<\/li>\n
  9. Fuchigami T, Ogawa A, Yamashita Y, Haratake M, Watanabe H, Ono M, Kawasaki M, Yoshida S, Nakayama M.
    \nDevelopment of alkoxy styrylchromone derivatives for imaging of cerebral amyloid-\u03b2 plaques with SPECT
    \nBioorg. Med. Chem. Lett.\u00a0<\/em>25(16) 3363-3367 (2015)<\/li>\n
  10. Sano K, Ohashi M, Kanazaki K, Ding N, Deguchi J, Kanada Y, Ono M, Saji H.
    \n<\/span>In vivo photoacoustic imaging of cancer using indocyanine green-labeled monoclonal antibody targeting the epidermal growth factor receptor
    \nBiochem. Biophys. Res. Commun<\/em>. <\/em>464(3) 820-825 (2015)<\/li>\n
  11. Kawashima H, Kimura H, Nakaya Y, Tomatsu K, Arimitsu K, Nakanishi H, Ozeki E, Kuge Y, Saji H.
    \n<\/span>Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[11<\/sup>C]methylation with [11<\/sup>C]CH3<\/sub>I: Rapid Synthesis of [11<\/sup>C]Raclopride
    \nChem. Pharm. Bull. <\/em>63(9) 737-740 (2015)<\/li>\n
  12. Saji H.<\/span>
    \n<\/span>Application of Radioisotopes for Theranostics, a Combination of Diagnostics and Therapy
    \nYAKUGAKU ZASSHI\u00a0<\/em>135(4) 551-556 (2015)\u00a0Review<\/em>.<\/li>\n
  13. Nakamoto Y, Sano K, Ishimori T, Ueda M, Temma T, Saji H, Togashi K.<\/span>
    \nAdditional information gained by positron emission tomography with 68<\/sup>Ga-DOTATOC for suspected unknown primary or recurrent neuroendocrine tumor<\/span>s
    \nAnn. Nucl. Med.\u00a0<\/em>29(6) 512-518 (2015)<\/li>\n
  14. Hagimori M, Temma T, Mizuyama N, Uto T, Yamaguchi Y, Tominaga Y, Mukai T, Saji H.
    \nA high-affinity fluorescent Zn2+<\/sup> sensor improved by the suppression of pyridine-pyridone tautomerism and its application in living cells
    \n<\/span>Sens. Act. B.<\/em>\u00a0213\u00a045-52 (2015)<\/span><\/li>\n
  15. Yagi Y, Kimura H, Arimitsu K, Ono M, Maeda K, Kusuhara H, Kajimoto T, Sugiyama Y, Saji H.
    \nThe synthesis of [18<\/sup>F]pitavastatin as a tracer for hOATP using the Suzuki coupling
    \nOrg. Biomol. Chem.<\/em>\u00a013 1113-1121 (2015)<\/span><\/li>\n
  16. Watanabe H, Ono M, Iikuni S, Kimura H, Okamoto Y, Ihara M, Saji H.
    \nSynthesis and biological evaluation of\u00a0123<\/sup>I-labeled pyridyl benzoxazole derivatives: novel \u03b2-amyloid imaging probes for single-photon emission computed tomography<\/span>
    \nRSC Adv.\u00a0<\/em>5(2)\u00a01009-1015 (2015)<\/li>\n
  17. Temma T, Nishigori K, Onoe S, Sampei S, Kimura I, Ono M, Saji H.<\/span>
    \nRadiofluorinated probe for PET imaging of fatty acid binding protein 4 in cancer<\/span>
    \nNucl. Med. Biol. <\/em>42(2) 184-191 (2015)<\/li>\n
  18. Ono M, Saji H.
    \nRecent Advances in Molecular Imaging Probes for \u03b2-Amyloid Plaques
    \nMed. Chem. Commun.\u00a0<\/em>6(3) 391-402 (2015)\u00a0Review<\/em>.<\/li>\n
  19. Watanabe H, Ono M, Saji H.
    \nNovel PET\/SPECT Probes for Imaging of Tau in Alzheimer\u2019s Disease<\/span>
    \nScientificWorldJournal\u00a0<\/em>2015 124192 (2015)\u00a0Review.<\/em><\/li>\n
  20. Morishita M, Takahashi Y, Nishikawa M, Sano K, Kato K, Yamashita T, Imai T, Saji H, Takakura Y.
    \nQuantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice.
    \nJ. Pharm. Sci.\u00a0<\/em>104(2) 705-713\u00a0(2015)<\/li>\n
  21. Hagimori M, Mizuyama N, Tominaga Y,<\/span>\u00a0Mukai T, Saji H.
    \nA low-molecular-weight fluorescent sensor with Zn2+<\/sup> dependent bathochromic shift of emission wavelength and its imaging in living cells
    \n<\/span>Dyes Pigm.\u00a0<\/em>113\u00a0205-209 (2015)<\/li>\n
  22. Ueda<\/span>\u00a0M, Hisada H, Temma T, Shimizu Y, Kimura H, Ono M, Nakamoto Y, Togashi K,\u00a0Saji H.
    \nGallium-68-labeled Anti-HER2 Single Chain Fv Fragment: Development and In Vivo Monitoring of HER2 Expression<\/span>
    \nMol. Imaging Biol. <\/em>17(1) 102-110<\/span>\u00a0(2015)<\/li>\n<\/ol>\n

     <\/p>\n

    \n

    2015 (\u5b66\u4f1a\u767a\u8868)<\/h2>\n
      \n
    1. Hiroyuki Watanabe, Masahiro Ono, Ayane Kitada, Hideo Saji.
      \n<\/span>Development of radioiodinated pyrido[1,2-a]benzoimidazole derivatives as novel tau imaging probes for SPECT
      \nNinth Japan-China Joint Seminar on Radiopharmaceutical Chemistry<\/span>\uff08Chiba\uff09<\/span><\/li>\n
    2. Kohei Sano, Kengo Kanazaki, Akira Makino, Atsushi Takahashi, Fumio Yamauchi, Tsutomu Homma, Hiroyuki Watanabe, Takashi Temma, Masahiro Ono, Hideo Saji.<\/span>
      \n<\/span>Development of polyethylene glycol conjugated with indocyanine green as a photoacoustic tumor imaging probe
      \n<\/span>World Molecular Imaging Congress 2015<\/span>\uff08Honolulu, USA\uff09<\/span><\/li>\n
    3. Kohei Sano, Ning Ding, Kengo Kanazaki, Masahiro Ono, Hideo Saji.<\/span>
      \n<\/span>In vivo HER2-Targeted Magnetic Resonance Tumor Imaging Using Iron Oxide Nanoparticles Conjugated with Anti-HER2 Single Chain Antibody
      \nWorld Molecular Imaging Congress 2015<\/span>\uff08Honolulu, USA\uff09<\/span><\/li>\n
    4. Masashi Yoshimura, Masahiro Ono, Hiroyuki Watanabe, Hiroyuki Kimura, Hideo Saji.
      \n<\/span>Development of 99m<\/sup>Tc labeled pyridyl benzofuran derivatives for the imaging of islet amyloids in the pancreas
      \n<\/span>Society of Nuclear Medicine and Molecular Imaging 2015 Annual Meeting<\/span>\uff08Baltimore, USA\uff09<\/span><\/li>\n
    5. Masahiro Ono, Kenji Matsumura, Hiroyuki Watanabe, Hiroyuki Kimura, Hideo Saji.
      \n<\/span>Novel tau-SPECT imaging agents based on pyrido[1,2-a]benzoimidazole scaffold
      \n<\/span>Society of Nuclear Medicine and Molecular Imaging 2015 Annual Meeting<\/span>\uff08Baltimore, USA\uff09<\/span><\/li>\n
    6. Takashi Temma, Naoya Kondo, Masahiro Ono, Hideo Saji<\/span>.
      \n<\/span>18<\/sup>F-BODIPY labeled pegylated peptide probe for PET imaging of MT1-MMP activity in cancers
      \n<\/span>Society of Nuclear Medicine and Molecular Imaging 2015 Annual Meeting<\/span>\uff08Baltimore, USA\uff09
      \n<\/span><\/li>\n
    7. Hiroyuki Kimura, Noriyuki Ohneda, Hiro Odajima, Masahiro Ono, Hideo Saji<\/span>.
      \nDevelopment of a Continuous Flow Microwave Reactor and Its Application to the Radiochemistry<\/span>
      \n<\/span>21st International Symposium on Radiopharmaceutical Sciences<\/span>\uff08Columbia, USA\uff09<\/span><\/li>\n
    8. \u5409\u6751 \u512a\u5fd7, \u5c0f\u91ce \u6b63\u535a, \u6e21\u908a \u88d5\u4e4b, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u7cd6\u5c3f\u75c5\u81b5\u81d3\u5185\u306e\u30a2\u30df\u30ea\u30f3\u3092\u6a19\u7684\u3068\u3057\u305f125<\/sup>I-, 18<\/sup>F-\u30d5\u30a7\u30ce\u30ad\u30b7\u30e1\u30c1\u30eb\u30d4\u30ea\u30b8\u30f3\u8a98\u5c0e\u4f53\u306e\u5408\u6210\u3068\u8a55\u4fa1
      \n<\/span>\u7b2c55\u56de\u65e5\u672c\u6838\u533b\u5b66\u4f1a\uff08\u6771\u4eac\uff09<\/li>\n
    9. \u5965\u7530 \u60a0, \u6728\u6751 \u5bdb\u4e4b, \u7267\u91ce \u9855, \u6709\u5149 \u5065\u6cbb, \u5bae\u5d0e \u674f\u5948, \u6e21\u908a \u88d5\u4e4b, \u5ddd\u5d0e \u90c1\u52c7, \u897f\u51fa \u559c\u4ee3\u6cbb, \u897f\u4e95 \u9f8d\u4e00, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>EGFR\u306e\u4e8c\u6b21\u5909\u7570\u306e\u8b58\u5225\u3092\u76ee\u7684\u3068\u3057\u305fPET\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a
      \n<\/span>\u7b2c55\u56de\u65e5\u672c\u6838\u533b\u5b66\u4f1a\uff08\u6771\u4eac\uff09<\/li>\n
    10. \u98ef\u570b \u614e\u5e73, \u5c0f\u91ce \u6b63\u535a, \u6e21\u908a \u88d5\u4e4b, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u8133\u30a2\u30df\u30ed\u30a4\u30c9\u30a2\u30f3\u30ae\u30aa\u30d1\u30c1\u30fc\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305f\u65b0\u898f2\u4fa199m<\/sup>Tc\u932f\u4f53\u306e\u5408\u6210\u3068\u8a55\u4fa1
      \n<\/span>\u7b2c55\u56de\u65e5\u672c\u6838\u533b\u5b66\u4f1a\uff08\u6771\u4eac\uff09<\/li>\n
    11. \u4f50\u91ce \u7d18\u5e73, \u91d1\u7530 \u4f91\u5b50, \u91d1\u5d0e \u5065\u543e, \u4e01 \u5be7, \u5927\u6a4b \u611b\u7f8e, \u51fa\u53e3 \u8ac4, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u71b1\u5fdc\u7b54\u51dd\u96c6\u6027\u30dd\u30ea\u30de\u30fc\u578b\u653e\u5c04\u6027\u85ac\u5264\u3092\u7528\u3044\u308b\u5c0f\u7dda\u6e90\u7642\u6cd5\u306e\u958b\u767a\u7814\u7a76
      \n<\/span>\u7b2c55\u56de\u65e5\u672c\u6838\u533b\u5b66\u4f1a\uff08\u6771\u4eac\uff09<\/li>\n
    12. \u6e21\u908a \u88d5\u4e4b, \u5c0f\u91ce \u6b63\u535a, \u677e\u6751 \u61b2\u5fd7, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8133\u5185\u30bf\u30a6\u306e\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305f\u65b0\u898f\u653e\u5c04\u6027\u30d7\u30ed\u30fc\u30d6\u306e\u57fa\u790e\u7684\u8a55\u4fa1
      \n<\/span>\u7b2c55\u56de\u65e5\u672c\u6838\u533b\u5b66\u4f1a\uff08\u6771\u4eac\uff09<\/li>\n
    13. \u4f50\u91ce \u7d18\u5e73, \u91d1\u5d0e \u5065\u543e, \u4e01 \u5be7, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u816b\u760d\u767a\u73fe\u5206\u5b50\u306e\u30a4\u30f3\u30d3\u30dc\u78c1\u6c17\u5171\u9cf4\/\u5149\u97f3\u97ff\u30c7\u30e5\u30a2\u30eb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u6307\u3057\u305f\u9178\u5316\u9244\u7c92\u5b50\u3092\u57fa\u76e4\u3068\u3059\u308b\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u5275\u88fd
      \n<\/span>\u7b2c65\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u8fd1\u757f\u652f\u90e8\u7dcf\u4f1a\u30fb\u5927\u4f1a\uff08\u5927\u962a\uff09<\/span><\/li>\n
    14. \u6e21\u908a \u88d5\u4e4b, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \n\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8133\u5185\u306b\u304a\u3051\u308b\u03b2\u30a2\u30df\u30ed\u30a4\u30c9\u51dd\u96c6\u4f53\u3092\u6a19\u7684\u3068\u3059\u308b\u86cd\u5149\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a
      \n<\/span>\u7b2c65\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u8fd1\u757f\u652f\u90e8\u7dcf\u4f1a\u30fb\u5927\u4f1a<\/span>\uff08\u5927\u962a\uff09<\/span><\/li>\n
    15. \u4e01 \u5be7, \u4f50\u91ce \u7d18\u5e73, \u91d1\u5d0e \u5065\u543e, \u5927\u6a4b \u611b\u7f8e, \u51fa\u53e3 \u8ac4, \u91d1\u7530 \u4f91\u5b50, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u816b\u760d\u5185 HER2 \u306e MR \u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305f\u30ca\u30ce\u7c92\u5b50\u578b\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/span>
      \n<\/span>\u7b2c15\u56de\u653e\u5c04\u6027\u533b\u85ac\u54c1\u30fb\u753b\u50cf\u8a3a\u65ad\u85ac\u7814\u7a76\u4f1a\uff08\u4eac\u90fd\uff09<\/li>\n
    16. \u91d1\u5d0e \u5065\u543e, \u4f50\u91ce \u7d18\u5e73, \u7267\u91ce \u9855,\u00a0\u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u30a4\u30f3\u30c9\u30b7\u30a2\u30cb\u30f3\u30b0\u30ea\u30fc\u30f3\u7d50\u5408\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u3092\u6bcd\u4f53\u3068\u3057\u305f\u816b\u760d\u8a3a\u65ad\u7528\u5149\u97f3\u97ff\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/span>
      \n<\/span>\u7b2c15\u56de\u653e\u5c04\u6027\u533b\u85ac\u54c1\u30fb\u753b\u50cf\u8a3a\u65ad\u85ac\u7814\u7a76\u4f1a\uff08\u4eac\u90fd\uff09<\/li>\n
    17. \u5317\u7530 \u5f69\u97f3, \u5c0f\u91ce \u6b63\u535a, \u6e21\u908a \u88d5\u4e4b, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>SPECT \u7528\u30bf\u30a6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\u3092\u76ee\u7684\u3068\u3057\u305f\u30d9\u30f3\u30be\u30a4\u30df\u30c0\u30be\u30d4\u30ea\u30b8\u30f3\u8a98\u5c0e\u4f53\u306e\u5408\u6210\u3068\u8a55\u4fa1
      \n<\/span>\u7b2c13\u56de\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u30d5\u30a3\u30b8\u30ab\u30eb\u30fb\u30d5\u30a1\u30fc\u30de\u30d5\u30a9\u30fc\u30e9\u30e0<\/span>\uff08\u9577\u5d0e\uff09<\/span><\/li>\n
    18. \u6e21\u908a \u88d5\u4e4b, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \n\u30b8\u30e1\u30c1\u30eb\u30a2\u30df\u30ce\u30c1\u30aa\u30d5\u30a7\u30f3\u8a98\u5c0e\u4f53\u3092\u7528\u3044\u305f\u03b2\u30a2\u30df\u30ed\u30a4\u30c9\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u86cd\u5149\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/span>
      \n\u7b2c13\u56de\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u30d5\u30a3\u30b8\u30ab\u30eb\u30fb\u30d5\u30a1\u30fc\u30de\u30d5\u30a9\u30fc\u30e9\u30e0<\/span>\uff08\u9577\u5d0e\uff09<\/span><\/li>\n
    19. \u91d1\u7530 \u4f91\u5b50, \u4f50\u91ce \u7d18\u5e73, \u91d1\u5d0e \u5065\u543e, \u4e01 \u5be7, \u5927\u6a4b \u611b\u7f8e, \u51fa\u53e3 \u8ac4,\u00a0<\/span>\u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \nBrachytherapy using injectable and thermo-responsive polymers labeled with radiometal that are self-aggregated in tumor tissues
      \n<\/span>\u7b2c25\u56de\u91d1\u5c5e\u306e\u95a2\u4e0e\u3059\u308b\u751f\u4f53\u95a2\u9023\u53cd\u5fdc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0<\/span>\uff08\u9577\u5d0e\uff09<\/span><\/li>\n
    20. \u5ddd\ufa11 \u6893, \u6e21\u908a \u88d5\u4e4b,\u00a0<\/span>\u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \nSynthesis and evaluation of novel 64<\/sup>Cu labeled benzofuran derivatives as \u03b2-amyloid imaging probes<\/span>
      \n\u7b2c25\u56de\u91d1\u5c5e\u306e\u95a2\u4e0e\u3059\u308b\u751f\u4f53\u95a2\u9023\u53cd\u5fdc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0<\/span>\uff08\u9577\u5d0e\uff09<\/span><\/li>\n
    21. \u8fd1\u85e4 \u76f4\u54c9, \u5929\u6eff \u656c, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \nMT1-MMP \u306e\u9175\u7d20\u6d3b\u6027\u3092\u6a19\u7684\u3068\u3057\u305f 18<\/sup>F\u6a19\u8b58BODIPY\u5c0e\u5165PEG\u5316\u30da\u30d7\u30c1\u30c9\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/span>
      \n\u7b2c10\u56de\u65e5\u672c\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5b66\u4f1a \uff08\u6771\u4eac\uff09<\/span><\/li>\n
    22. \u571f\u4e95 \u96c4\u8cb4, \u5c0f\u91ce \u6b63\u535a, \u6e21\u908a \u88d5\u4e4b, \u677e\u6751 \u61b2\u5fd7, \u5409\u6751 \u512a\u5fd7, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.<\/span>
      \n\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u3092\u6a19\u7684\u3068\u3059\u308b\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a : \u65b0\u898f\u30ab\u30eb\u30b3\u30f3\u985e\u7e01\u4f53\u306e\u5408\u6210\u3068\u8a55\u4fa1<\/span>
      \n\u7b2c10\u56de\u65e5\u672c\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5b66\u4f1a \uff08\u6771\u4eac\uff09<\/span><\/li>\n
    23. \u6e21\u908a \u88d5\u4e4b, \u5c0f\u91ce \u6b63\u535a, \u677e\u6751 \u61b2\u5fd7, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.<\/span>
      \n\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8133\u5185\u30bf\u30a6\u51dd\u96c6\u4f53\u306e\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305fPET\/SPECT\u7528\u30d7\u30ed\u30fc\u30d6\u306e<\/span>\u958b\u767a<\/span>
      \n\u7b2c10\u56de\u65e5\u672c\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5b66\u4f1a \uff08\u6771\u4eac\uff09<\/span><\/li>\n
    24. \u8fd1\u85e4 \u76f4\u54c9, \u5929\u6eff \u656c, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.
      \nMT1-MMP \u6d3b\u6027\u306e PET \u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u305f\u3081\u306e18<\/sup>F\u6a19\u8b58BODIPY\u5c0e\u5165PEG\u5316\u30da\u30d7\u30c1\u30c9\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/span>
      \n\u65e5\u672c\u85ac\u5b66\u4f1a \u7b2c135\u5e74\u4f1a \uff08\u795e\u6238\uff09<\/span><\/li>\n
    25. \u677e\u6751 \u61b2\u5fd7, \u5c0f\u91ce \u6b63\u535a, \u5317\u7530 \u5f69\u97f3, \u6e21\u908a \u88d5\u4e4b, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8133\u5185\u30bf\u30a6\u306e\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305f\u65b0\u898f\u653e\u5c04\u6027\u30e8\u30a6\u7d20\u6a19\u8b58\u30d9\u30f3\u30be\u30a4\u30df\u30c0\u30be\u30d4\u30ea\u30b8\u30f3\u8a98\u5c0e\u4f53\u306e\u958b\u767a<\/span>
      \n<\/span>\u65e5\u672c\u85ac\u5b66\u4f1a \u7b2c135\u5e74\u4f1a \uff08\u795e\u6238\uff09<\/span><\/li>\n
    26. \u5409\u6751 \u512a\u5fd7, \u5c0f\u91ce \u6b63\u535a, \u6e21\u908a \u88d5\u4e4b, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.
      \n<\/span>\u81b5\u5cf6\u5185\u30a2\u30df\u30ea\u30f3\u306e\u751f\u4f53\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305f99m<\/sup>Tc \u6a19\u8b58\u30d4\u30ea\u30b8\u30eb\u30d9\u30f3\u30be\u30d5\u30e9\u30f3\u8a98\u5c0e\u4f53\u306e\u958b\u767a
      \n<\/span>\u65e5\u672c\u85ac\u5b66\u4f1a \u7b2c135\u5e74\u4f1a \uff08\u795e\u6238\uff09<\/span><\/li>\n
    27. \u98ef\u570b \u614e\u5e73, \u5c0f\u91ce \u6b63\u535a, \u6e21\u908a \u88d5\u4e4b, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.
      \n\u8133\u30a2\u30df\u30ed\u30a4\u30c9\u30a2\u30f3\u30ae\u30aa\u30d1\u30c1\u30fc\u306e\u6838\u533b\u5b66\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305f99m<\/sup>Tc \u6a19\u8b58\u30d9\u30f3\u30be\u30c1\u30a2\u30be\u30fc\u30eb\u8a98\u5c0e\u4f53\u306e\u958b\u767a
      \n<\/span>\u65e5\u672c\u85ac\u5b66\u4f1a \u7b2c135\u5e74\u4f1a \uff08\u795e\u6238\uff09<\/span><\/li>\n
    28. \u91d1\u5d0e \u5065\u543e, \u4f50\u91ce \u7d18\u5e73, \u7267\u91ce \u9855, \u5c71\u5185 \u6587\u751f, \u672c\u9593 \u52d9, \u6e21\u908a \u88d5\u4e4b, \u5929\u6eff \u656c, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb\u82f1\u90ce.
      \n<\/span>\u5149\u97f3\u97ff\u816b\u760d\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u305f\u3081\u306e\u30a4\u30f3\u30c9\u30b7\u30a2\u30cb\u30f3\u30b0\u30ea\u30fc\u30f3\u7d50\u5408\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306e\u958b\u767a<\/span>
      \n\u65e5\u672c\u85ac\u5b66\u4f1a \u7b2c135\u5e74\u4f1a \uff08\u795e\u6238\uff09<\/span><\/li>\n
    29. \u5c3e\u6c5f \u609f, \u5929\u6eff \u656c, \u6e21\u908a \u88d5\u4e4b, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.<\/span>
      \n\u304c\u3093\u306e\u30a4\u30f3\u30d3\u30dc\u5149\u97f3\u97ff\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305f Triplet-singlet quencher \u7d50\u5408\u8272\u7d20\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a
      \n<\/span>\u65e5\u672c\u85ac\u5b66\u4f1a \u7b2c135\u5e74\u4f1a \uff08\u795e\u6238\uff09<\/span><\/li>\n
    30. \u5317\u7530 \u5f69\u97f3, \u5c0f\u91ce \u6b63\u535a, \u677e\u6751 \u61b2\u5fd7, \u5bae\u5d0e \u674f\u5948, \u6e21\u908a \u88d5\u4e4b, \u6728\u6751 \u5bdb\u4e4b, \u4f50\u6cbb \u82f1\u90ce.<\/span>
      \n\u30bf\u30a6\u30aa\u30d1\u30c1\u30fc\u306e\u65e9\u671f\u8a3a\u65ad\u3092\u76ee\u6307\u3057\u305f GSK-3\u03b2 \u6a19\u7684\u6838\u533b\u5b66\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a
      \n<\/span>\u65e5\u672c\u85ac\u5b66\u4f1a \u7b2c135\u5e74\u4f1a \uff08\u795e\u6238\uff09<\/span><\/li>\n
    31. \u4e01 \u5be7, \u4f50\u91ce \u7d18\u5e73, \u51fa\u53e3 \u8ac4, \u5927\u6a4b \u611b\u7f8e, \u91d1\u7530 \u4f91\u5b50, \u5c0f\u91ce \u6b63\u535a, \u4f50\u6cbb \u82f1\u90ce.<\/span>
      \n\u816b\u760d\u5185 HER2(Epidermal Growth Factor Receptor 2)\u3092\u6a19\u7684\u3068\u3059\u308b MR \u9020\u5f71\u5264\u306e\u958b\u767a
      \n<\/span>\u65e5\u672c\u85ac\u5b66\u4f1a \u7b2c135\u5e74\u4f1a \uff08\u795e\u6238\uff09<\/span><\/li>\n<\/ol>\n

       <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      2015 (\u8ad6\u6587) Kondo N, Temma T, Deguchi J, Sano K, Ono M, Saji H. Development of PEGylated peptide probes conjugat […]<\/p>\n","protected":false},"author":14,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2562","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/2562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=2562"}],"version-history":[{"count":4,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/2562\/revisions"}],"predecessor-version":[{"id":2567,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/2562\/revisions\/2567"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=2562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}