{"id":2576,"date":"2020-01-18T11:08:44","date_gmt":"2020-01-18T02:08:44","guid":{"rendered":"http:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/?page_id=2576"},"modified":"2020-01-18T11:08:44","modified_gmt":"2020-01-18T02:08:44","slug":"%e8%86%9c%e7%b5%90%e5%90%88%e5%9e%8b%e3%83%9e%e3%83%88%e3%83%aa%e3%82%af%e3%82%b9%e3%83%a1%e3%82%bf%e3%83%ad%e3%83%97%e3%83%ad%e3%83%86%e3%82%a2%e3%83%bc%e3%82%bc-1%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/%e8%86%9c%e7%b5%90%e5%90%88%e5%9e%8b%e3%83%9e%e3%83%88%e3%83%aa%e3%82%af%e3%82%b9%e3%83%a1%e3%82%bf%e3%83%ad%e3%83%97%e3%83%ad%e3%83%86%e3%82%a2%e3%83%bc%e3%82%bc-1%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8\/","title":{"rendered":"\u819c\u7d50\u5408\u578b\u30de\u30c8\u30ea\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc-1\u3092\u6a19\u7684\u3068\u3057\u305f\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a"},"content":{"rendered":"

\u819c\u7d50\u5408\u578b\u30de\u30c8\u30ea\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc-1\u3092\u6a19\u7684\u3068\u3057\u305f\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/h2>\n

\u819c\u7d50\u5408\u578b\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc-1\uff08MT1-MMP\uff09\u306f\u3001\u304c\u3093\u7d30\u80de\u5916\u57fa\u8cea\u306e\u5206\u89e3\u306b\u76f4\u63a5\u7684\u306b\u95a2\u4e0e\u3059\u308b\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc-2\u306e\u6d3b\u6027\u5316\u56e0\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3001\u816b\u760d\u5f62\u6210\u306e\u65e9\u671f\u3088\u308a\u767a\u73fe\u3057\u3001\u305d\u306e\u767a\u73fe\u91cf\u304c\u60aa\u6027\u5ea6\u3068\u76f8\u95a2\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001\u816b\u760d\u306e\u8cea\u7684\u8a3a\u65ad\u3092\u76ee\u7684\u3068\u3057\u3066\u3001MT1-MMP\u3092\u6a19\u7684\u5206\u5b50\u3068\u3059\u308b\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\u3092\u8a08\u753b\u3057\u305f\u3002<\/p>\n

MT1-MMP\u3092\u6a19\u7684\u5206\u5b50\u3068\u3059\u308b\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\u306b\u304a\u3044\u3066\u306f\u3001\u4e8c\u5b98\u80fd\u6027\u30ad\u30ec\u30fc\u30c8\u5206\u5b50\u306e\u6982\u5ff5\u306b\u57fa\u3065\u304d\u3001\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u9069\u3057\u305f\u7dda\u8cea\u30fb\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6709\u3059\u308b99m<\/sup>Tc\u3092\u3001\u6297MT1-MMP\u6297\u4f53\u306e\u6297\u539f\u8a8d\u8b58\u90e8\u4f4d\u3068\u306f\u7570\u306a\u308b\u90e8\u4f4d\u306b\u3001Hydrazino-nicotinicacid\uff08HYNIC\uff09\u3092\u4ecb\u3057\u3066\u5b89\u5b9a\u306b\u7d50\u5408\u3055\u305b\u305f99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u3092\u4f5c\u88fd\u3057\u305f\u3002\u6b21\u306b\u4e73\u304c\u3093\u79fb\u690d\u52d5\u7269\u3092\u4f5c\u88fd\u3057\u3001\u6458\u51fa\u3057\u305f\u816b\u760d\u7d44\u7e54\u306b\u304a\u3051\u308bMT1-MMP\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u78ba\u8a8d\u3057\u305f\u5f8c\u3001\u305d\u306e\u52d5\u7269\u306b99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u3092\u6295\u4e0e\u3057\u3066\u7d4c\u6642\u7684\u306a\u751f\u4f53\u5185\u653e\u5c04\u80fd\u5206\u5e03\u5909\u5316\u3092\u81d3\u5668\u6458\u51fa\u6cd5\u306b\u3088\u308a\u8abf\u3079\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u816b\u760d\u3078\u306e\u653e\u5c04\u80fd\u96c6\u7a4d\u91cf\u304a\u3088\u3073\u816b\u760d\u306b\u304a\u3051\u308b\u8840\u6db2\u306b\u5bfe\u3059\u308b\u653e\u5c04\u80fd\u96c6\u7a4d\u6bd4\uff08T\/B\u6bd4\uff09\u306f\u7d4c\u6642\u7684\u306b\u5897\u52a0\u3057\u3001\u305d\u308c\u3089\u306e\u5024\u306f99m<\/sup>Tc\u6a19\u8b58\u30cd\u30ac\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u6297\u4f53\u3092\u6295\u4e0e\u3057\u305f\u5bfe\u7167\u5b9f\u9a13\u3068\u6bd4\u3079\u3066\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u3088\u308a\u300199m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u304c\u3001MT1-MMP\u306e\u7279\u7570\u7684\u691c\u51fa\u306b\u9069\u3057\u305f\u653e\u5c04\u6027\u85ac\u5264\u3068\u306a\u308a\u5f97\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n

\u307e\u305f\u3001MT1-MMP\u306f\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u4e0d\u5b89\u5b9a\u5316\u306b\u3082\u5bc6\u63a5\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u6211\u3005\u306f99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u3092\u7528\u3044\u305f\u52d5\u8108\u786c\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u95a2\u3059\u308b\u691c\u8a0e<\/a>\u3082\u884c\u3063\u305f\u3002<\/p>\n

\"MT1AbforHP\"<\/a>

\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n

 <\/p>\n

\u4e00\u65b9\u3001\u4e0a\u8a18\u306e99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u306f\u975e\u6a19\u7684\u7d44\u7e54\u304b\u3089\u306e\u653e\u5c04\u80fd\u6d88\u5931\u304c\u9045\u304f\u3001\u816b\u760d\u3092\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\u305f\u3081\u306b\u306f\u6295\u4e0e\u5f8c48\u6642\u9593\u4ee5\u4e0a\u306e\u9577\u6642\u9593\u3092\u8981\u3059\u308b\u3053\u3068\u3092\u8a8d\u3081\u3001\u653e\u5c04\u6027\u6838\u7a2e\u306e\u534a\u6e1b\u671f\u304b\u3089\u3001\u3088\u308a\u65e9\u671f\u3067\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u53ef\u80fd\u3068\u3059\u308b\u65b9\u6cd5\u306e\u958b\u767a\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u305f\u3002<\/p>\n

\u305d\u3053\u3067\u3001\u653e\u5c04\u6027\u85ac\u5264\u306e\u6295\u4e0e\u5f8c\u65e9\u671f\u306b\u816b\u760d\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u53ef\u80fd\u3068\u3059\u308b\u305f\u3081\u306b\u3001\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\uff08SAv\uff09\u3068\u30d3\u30aa\u30c1\u30f3\uff08Bt\uff09\u306e\u9ad8\u3044\u89aa\u548c\u6027\u30fb\u7279\u7570\u6027\u3092\u5229\u7528\u3057\u3066\u3001\u307e\u305a\u62c5\u304c\u3093\u30de\u30a6\u30b9\u306bSAv\u7d50\u5408\u6297MT1-MMP\u6297\u4f53\u3092\u6295\u4e0e\u3057\u3001\u305d\u308c\u304c\u816b\u760d\u306eMT1-MMP\u306b\u7d50\u5408\u3057\u305f\u5f8c\u306b\u3001\u4f4e\u5206\u5b50\u306e\u305f\u3081\u975e\u6a19\u7684\u7d44\u7e54\u304b\u3089\u306e\u901f\u3084\u304b\u306a\u6d88\u5931\u304c\u671f\u5f85\u3055\u308c\u308b123<\/sup>I\u6a19\u8b58Bt\uff08123<\/sup>I-(3-iodobenzoyl) norbiotinamide\uff08123<\/sup>I-IBB\uff09\uff09\u3092\u6295\u4e0e\u3057\u3066\u3001\u3053\u308c\u3092\u751f\u4f53\u5185\u3067\u816b\u760d\u306eMT1-MMP\u306b\u7d50\u5408\u3055\u305b\u308b\u3068\u3044\u3046\u3001\u30d7\u30ec\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u6cd5\u3092\u8003\u6848\u3057\u305f\u3002SAv\u7d50\u5408\u6297MT1-MMP\u6297\u4f53\u306e\u6295\u4e0e72\u6642\u9593\u5f8c\u306b125<\/sup>I-IBB\u3092\u6295\u4e0e\u3057\u305f\u7d50\u679c\u3001\u816b\u760d\u90e8\u4f4d\u3078\u96c6\u7a4d\u3057\u305f\u653e\u5c04\u80fd\u306f\u9577\u6642\u9593\u4fdd\u6301\u3055\u308c\u305f\u4e00\u65b9\u3067\u3001\u8840\u4e2d\u653e\u5c04\u80fd\u306f\u901f\u3084\u304b\u306b\u6d88\u5931\u3057\u305f\u3053\u3068\u304b\u3089\u3001T\/B\u6bd4\u306f\u30d7\u30ed\u30fc\u30d6\u6295\u4e0e\u5f8c\u65e9\u671f\u3088\u308a99m<\/sup>Tc\u6a19\u8b58\u6297MT1-MMP\u6297\u4f53\u3068\u6bd4\u3079\u3066\u6709\u610f\u306b\u9ad8\u3044\u5024\u3092\u793a\u3057\u305f\u3002\u307e\u305f\u3001125<\/sup>I-IBB\u3092\u5358\u72ec\u3067\u6295\u4e0e\u3057\u305f\u5834\u5408\u3001\u816b\u760d\u90e8\u4f4d\u3078\u306e\u653e\u5c04\u80fd\u96c6\u7a4d\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u30d7\u30ec\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u6cd5\u3067\u8a8d\u3081\u3089\u308c\u305f\u816b\u760d\u90e8\u4f4d\u3078\u306e\u653e\u5c04\u80fd\u96c6\u7a4d\u306f\u524d\u6295\u4e0e\u3057\u305fSAv\u7d50\u5408\u6297\u4f53\u306b\u3088\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3001\u30d7\u30ec\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u6cd5\u306e\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u30d7\u30ec\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u6cd5\u3092\u7528\u3044\u3066\u3001\u62c5\u304c\u3093\u30de\u30a6\u30b9\u3067\u306e\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5b9f\u9a13\u3092\u884c\u3063\u305f\u7d50\u679c\u3001123<\/sup>I-IBB\u6295\u4e0e\u5f8c\u65e9\u671f\u306b\u304a\u3051\u308b\u660e\u77ad\u306a\u816b\u760d\u90e8\u4f4d\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u6210\u529f\u3057\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001SAv\u7d50\u5408\u6297MT1-MMP\u6297\u4f53\u3068123<\/sup>I-IBB\u3092\u7528\u3044\u308b\u30d7\u30ec\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u6cd5\u306f\u3001\u6295\u4e0e\u5f8c\u65e9\u671f\u306b\u304a\u3051\u308bMT1-MMP\u3092\u6a19\u7684\u3068\u3059\u308b\u816b\u760d\u306e\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u660e\u3089\u304b\u3068\u3057\u305f\u3002
\n\u3055\u3089\u306b\u6700\u8fd1\u3067\u306f\u3001\u4e0a\u8a18\u306e\u30d7\u30ec\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u6cd5\u306e\u6982\u5ff5\u3092MRI\u306b\u3088\u308b\u8cea\u7684\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3078\u3068\u5c55\u958b\u3059\u308b\u8a66\u307f\u3082\u884c\u3063\u3066\u304a\u308a\u3001\u30d7\u30ec\u6295\u4e0e\u3057\u305fSAv\u7d50\u5408\u6297MT1-MMP\u6297\u4f53\u4f9d\u5b58\u7684\u306b\u3001\u591a\u304f\u306eGd\u932f\u4f53\u3092\u4fee\u98fe\u3057\u305f\u30c7\u30f3\u30c9\u30ea\u30de\u30fc\u3092\u304c\u3093\u7d44\u7e54\u3078\u9001\u9054\u3067\u304d\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u3068\u3057\u3066\u3044\u308b\u3002<\/p>\n

\"MT1AbforHP2\"<\/a>

\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n

\u4e3b\u8981\u8ad6\u6587<\/h3>\n
    \n
  • Development of PEGylated peptide probes conjugated with\u00a018<\/sup>F-labeled BODIPY for PET\/optical imaging of MT1-MMP activity
    \nJ. Control. Release\u00a0<\/em>220<\/strong>\u00a0476-483 (2015)<\/span><\/li>\n
  • In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase With a Novel\u00a0Activatable Near-Infrared Fluorescence Probe.
    \nCancer Sci.<\/em>\u00a0105<\/strong>\uff088) 1056-1062 (2014)<\/span><\/li>\n
  • Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers.
    \nCancer Sci.<\/em>\u00a0104<\/strong>\u00a0(4) 495-501 (2013<\/span><\/span>)<\/span><\/span><\/span><\/li>\n
  • A Pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast Agents.
    \nMol. Imaging Biol.<\/em>\u00a013<\/strong>\u00a0(6) 1196-1203 (2011)<\/span><\/li>\n
  • Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method.
    \nBiol. Pharm. Bull.<\/em>\u00a033<\/strong>\u00a0(9) 1589-1595 (2010)<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

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