{"id":287,"date":"2013-06-18T17:39:37","date_gmt":"2013-06-18T08:39:37","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=287"},"modified":"2025-03-24T18:19:48","modified_gmt":"2025-03-24T09:19:48","slug":"research09","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/molecular-imaging\/research09\/","title":{"rendered":"\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u305f\u3081\u306e\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u958b\u767a"},"content":{"rendered":"<h2>\u8fd1\u8d64\u5916\u86cd\u5149A\u03b2\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/h2>\n<p>\u86cd\u5149\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306f\u3001\u7ba1\u7406\u533a\u57df\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u305f\u3081\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u6bd4\u3079\u3066\u7c21\u4fbf\u306b\u6271\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3055\u3089\u306b\u3001\u86cd\u5149\u306e\u30aa\u30f3\u30aa\u30d5\u5236\u5fa1\u3092\u5229\u7528\u3057\u305f\u9ad8\u3044\u6a19\u7684\u975e\u6a19\u7684\u30b7\u30b0\u30ca\u30eb\u5f37\u5ea6\u3092\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u7279\u306b\u3001650~900nm\u306e\u8fd1\u8d64\u5916\u9818\u57df\u306f\u5149\u306e\u6563\u4e71\u304c\u5c11\u306a\u304f\u3001\u751f\u4f53\u900f\u904e\u6027\u304c\u9ad8\u3044\u305f\u3081\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u9069\u3057\u305f\u9818\u57df\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u3001\u304c\u3093\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u8a3a\u65ad\u3092\u76ee\u7684\u3068\u3057\u305f\u8fd1\u8d64\u5916\u86cd\u5149\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n<p>\u8fd1\u8d64\u5916\u86cd\u5149A\u03b2\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306b\u6c42\u3081\u3089\u308c\u308b\u6761\u4ef6\u3068\u3057\u3066\u3001\u8fd1\u8d64\u5916\u9818\u57df\u306b\u52b1\u8d77\u30fb\u86cd\u5149\u6ce2\u9577\u3092\u6709\u3059\u308b\u3053\u3068\u3001A\u03b2\u7d50\u5408\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u3001\u304a\u3088\u3073\u751f\u4f53\u5185\u3078\u6295\u4e0e\u5f8c\u306b\u8133\u3078\u79fb\u884c\u3059\u308b\u3053\u3068\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u308b\u3002\u305d\u3053\u3067\u3001\u96fb\u5b50\u5438\u5f15\u57fa\u3068\u96fb\u5b50\u4f9b\u4e0e\u57fa\u30921\u5206\u5b50\u5185\u306b\u5c0e\u5165\u3057\u305fpush-pull\u69cb\u9020\u306e\u6982\u5ff5\u3092\u57fa\u76e4\u3068\u3057\u305f\u5206\u5b50\u3092\u958b\u767a\u3057\u3066\u304d\u305f\u3002\u306a\u304b\u3067\u3082\u3001DANIR2c\u304a\u3088\u3073DTM-2\u306f\u3001AD\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u8133\u306b\u84c4\u7a4d\u3057\u305fA\u03b2\u306e\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u6210\u529f\u3057\u3066\u3044\u308b\u3002<a href=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2019\/09\/\u86cd\u5149\u7d39\u4ecb1.png\" class=\"liimagelink\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2510\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2019\/09\/\u86cd\u5149\u7d39\u4ecb1.png\" alt=\"\" width=\"1754\" height=\"1239\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2019\/09\/\u86cd\u5149\u7d39\u4ecb1.png 1754w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2019\/09\/\u86cd\u5149\u7d39\u4ecb1-300x212.png 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2019\/09\/\u86cd\u5149\u7d39\u4ecb1-768x543.png 768w, https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/files\/2019\/09\/\u86cd\u5149\u7d39\u4ecb1-1024x723.png 1024w\" sizes=\"auto, (max-width: 1754px) 100vw, 1754px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h3>\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ul>\n<li><span class=\"Apple-style-span\">Combined strategies for optimizing BODIPY-based near-infrared fluorescent probe targeting A\u03b2 oligomers<\/span><span class=\"Apple-style-span\"><br \/>\n<\/span><span class=\"Apple-style-span\"><span lang=\"EN-US\"><em>Sens. Actuators B Chem.<\/em>, 417 136132 (2024)<\/span><\/span><\/li>\n<li><span class=\"Apple-style-span\">Development of triphenylmethane dyes for in vivo fluorescence imaging of A\u03b2 oligomers<\/span><span class=\"Apple-style-span\"><br \/>\n<\/span><span class=\"Apple-style-span\"><span lang=\"EN-US\"><em>ACS Chem. Neurosci.<\/em> 15(11) 2233-2242 (2024)<\/span><\/span><\/li>\n<li><span class=\"Apple-style-span\"><em>In vivo<\/em> Near-Infrared Fluorescence Imaging Selective for Soluble Amyloid \u03b2 Aggregates Using y-Shaped BODIPY Derivative<\/span><span class=\"Apple-style-span\"><br \/>\n<span lang=\"EN-US\"><em>J. Med. Chem.<\/em> 66(20) 14029-14046 (2023)<\/span><\/span><\/li>\n<li>Novel benzothiazole derivatives as fluorescent probes for detection of \u03b2-amyloid and \u03b1-synuclein aggregates<br \/>\n<em>ACS Chem. Neurosci.<\/em>\u00a08(8) 1656-1662 (2017)<\/li>\n<li>In Vivo Fluorescence Imaging of \u03b2-Amyloid Plaques with Push-Pull Dimethylaminothiophene Derivatives<br \/>\n<em>Chem. Commun.<\/em>\u00a051(96) 17124-17127 (2015)<\/li>\n<li>Smart Near-Infrared Fluorescence Probes with Donor-Acceptor Structure for in vivo Detection of \u03b2-Amyloid Deposits<br \/>\n<em>J. Am. Chem. Soc.<\/em>\u00a0136(9) 3388-3394 (2014)<\/li>\n<li>BODIPY-based molecular probe for imaging of cerebral \u03b2-amyloid plaques<br \/>\n<em>ACS Chem. Neurosci.<\/em>\u00a03(4) 319-324 (2012)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u8d64\u5916\u86cd\u5149A\u03b2\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a \u86cd\u5149\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306f\u3001\u7ba1\u7406\u533a\u57df\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u305f\u3081\u6838\u533b\u5b66\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u6bd4\u3079\u3066\u7c21\u4fbf\u306b\u6271\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3055\u3089\u306b\u3001\u86cd\u5149\u306e\u30aa\u30f3\u30aa\u30d5\u5236\u5fa1\u3092\u5229\u7528\u3057\u305f\u9ad8\u3044\u6a19\u7684\u975e\u6a19\u7684\u30b7\u30b0\u30ca\u30eb\u5f37\u5ea6\u3092\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":133,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","footnotes":""},"class_list":["post-287","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/287","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=287"}],"version-history":[{"count":5,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/287\/revisions"}],"predecessor-version":[{"id":3255,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/287\/revisions\/3255"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/133"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}