{"id":291,"date":"2013-06-18T17:44:16","date_gmt":"2013-06-18T08:44:16","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=291"},"modified":"2019-09-21T14:08:06","modified_gmt":"2019-09-21T05:08:06","slug":"research12","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/theme-list\/molecular-imaging\/research12\/","title":{"rendered":"\u7cd6\u5c3f\u75c5\u306e\u8d85\u65e9\u671f\u30fb\u4e88\u9632\u8a3a\u65ad\u306e\u305f\u3081\u306e\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a"},"content":{"rendered":"

Glucagon-like peptide-1(GLP-1)\u53d7\u5bb9\u4f53\u3092\u6a19\u7684\u3068\u3057\u305f\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a<\/h2>\n

\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u8d85\u65e9\u671f\u30fb\u4e88\u9632\u8a3a\u65ad\u3092\u76ee\u6307\u3057\u3066\u3001\u81b5\u5cf6\u03b2\u7d30\u80de\u306b\u7279\u7570\u7684\u30fb\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3059\u308bPET\/SPECT\u7528\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u3092\u8a2d\u8a08\u30fb\u5275\u751f\u3057\u3001\u305d\u308c\u3092\u7528\u3044\u3066\u81b5\u5cf6\u03b2\u7d30\u80de\u6570\u3092\u4f53\u5916\u304b\u3089\u975e\u4fb5\u8972\u7684\u306b\u5b9a\u91cf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\u65b9\u6cd5\u3092\u69cb\u7bc9\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002<\/p>\n

\u6700\u8fd1\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u62c5\u3046\u81b5\u5cf6\u03b2\u7d30\u80de\u304c\u7cd6\u5c3f\u75c5\u767a\u75c7\u524d\u304b\u3089\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u81b5\u5cf6\u03b2\u7d30\u80de\u6570\u306e\u975e\u4fb5\u8972\u7684\u5b9a\u91cf\u3092\u53ef\u80fd\u3068\u3059\u308b\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6cd5\u306e\u958b\u767a\u306f\u3001\u8d85\u65e9\u671f\u6bb5\u968e\u3067\u306e\u03b2\u7d30\u80de\u6570\u6e1b\u5c11\u3092\u691c\u51fa\u3057\u3066\u7cd6\u5c3f\u75c5\u767a\u75c7\u524d\u306e\u4e88\u9632\u7684\u4ecb\u5165\u3092\u53ef\u80fd\u306b\u3059\u308b\u306e\u307f\u306a\u3089\u305a\u3001\u7cd6\u5c3f\u75c5\u767a\u75c7\u904e\u7a0b\u306e\u75c5\u614b\u89e3\u660e\u3084\u03b2\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u958b\u767a\u306b\u3082\u8ca2\u732e\u3057\u5f97\u308b\u3053\u3068\u304b\u3089\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u308b\u6210\u679c\u306f\u975e\u5e38\u306b\u610f\u7fa9\u6df1\u3044\u3082\u306e\u3068\u306a\u308b\uff08\u4e0b\u56f3\uff09\u3002<\/p>\n

\u672c\u7814\u7a76\u3067\u306f\u7279\u306b\u3001\u81b5\u03b2\u7d30\u80de\u306b\u767a\u73fe\u3057\u3066\u304a\u308a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308bGlucagon-like peptide-1\uff08GLP-1\uff09\u53d7\u5bb9\u4f53\u306b\u7740\u76ee\u3057\u3001\u305d\u306e\u30da\u30d7\u30c1\u30c9\u6027\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308bExendin\u3092\u6bcd\u4f53\u3068\u3057\u305fPET\/SPECT\u7528\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30fc\u30d6\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u308b\u3002<\/p>\n

\"Diabetes\"<\/a>

\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u8868\u793a\u3057\u307e\u3059\u3002<\/p><\/div>\n

\u95a2\u9023\u8ad6\u6587<\/h3>\n
    \n
  • Evaluation of 18<\/sup>F-Labeled Exendin(9-39) Derivatives Targeting Glucagon-like Peptide-1 Receptor for Pancreatic \u03b2-cell Imaging<\/span>
    \nBioorg. Med. Chem.<\/em>, 26<\/strong><\/span> <\/strong>463-469 (2018).<\/li>\n
  • Synthesis and Biological Evaluation of an 111<\/sup>In-Labeled Exendin-4 Derivative as a SPECT probe for Imaging of Pancreatic \u03b2-cells.
    \nBioorg. Med. Chem.<\/span><\/em>, 25<\/strong><\/span> <\/strong>5772-5778 (2017).<\/li>\n
  • GLP-1 receptor antagonist as a potential probe for pancreatic -cell imaging.
    \nBiochemical and Biophysical Research Communications.<\/em> 389 <\/strong>523-526 (2009).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Glucagon-like peptide-1(GLP-1)\u53d7\u5bb9\u4f53\u3092\u6a19\u7684\u3068\u3057\u305f\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u306e\u958b\u767a \u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u8d85\u65e9\u671f\u30fb\u4e88\u9632\u8a3a\u65ad\u3092\u76ee\u6307\u3057\u3066\u3001\u81b5\u5cf6\u03b2\u7d30\u80de\u306b\u7279\u7570\u7684\u30fb\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3059\u308bPET\/SPECT\u7528\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":133,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-291","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=291"}],"version-history":[{"count":5,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/291\/revisions"}],"predecessor-version":[{"id":2495,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/291\/revisions\/2495"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/133"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}