{"id":334,"date":"2013-06-19T15:09:21","date_gmt":"2013-06-19T06:09:21","guid":{"rendered":"http:\/\/www.keyton-co.jp\/kpharm\/byotai\/?page_id=334"},"modified":"2013-10-10T20:29:02","modified_gmt":"2013-10-10T11:29:02","slug":"saji-hideo","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/member\/saji-hideo\/","title":{"rendered":"\u4f50\u6cbb\u3000\u82f1\u90ce"},"content":{"rendered":"

Hideo Saji, Ph.D.<\/p>\n

\"\u4f50\u6cbb\u5148\u751f\u5199\u771f\"Department of Patho-Functional Bioanalysis<\/span>
Professor<\/p>\n

Kyoto University
Graduate School of Pharmaceutical Sciences
46-29 Yoshida Shimoadachi-cho, Sakyo-ku,
Kyoto 606-8501, Japan<\/p>\n\n\n\n\n\n
Phone<\/span>:<\/td>\n+81-75-753-4556\u00a0<\/td>\n<\/tr>\n
Fax<\/span><\/td>\n+81-75-753-4568<\/td>\n<\/tr>\n
E-mail<\/span><\/td>\n\"saji-mail\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Biography<\/h2>\n

Education:<\/h3>\n

Undergraduate Course<\/h4>\n\n\n<\/colgroup>\n\n\n
1970-1974:<\/td>\nFaculty of Pharmaceutical Sciences, Kyoto University.
Major: Pharmaceutical Sciences. Degree B.S.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Graduate Course<\/h4>\n\n\n<\/colgroup>\n\n\n\n
1974-1976:\u00a0<\/td>\nGraduate School of Pharmaceutical Sciences, Kyoto University
Major: Radiopharmaceutical Chemistry. Degree M.S.<\/td>\n<\/tr>\n
1976-1980:\u00a0<\/td>\nGraduate School of Pharmaceutical Sciences, Kyoto University
Major: Radiopharmaceutical Chemistry. Degree Ph.D.\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Professional Appointments:<\/h3>\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n
1977-1980:\u00a0<\/td>\nInstructor
School of Medicine, Kyoto University
Department of Nuclear Medicine.\u00a0<\/td>\n<\/tr>\n
1980-1982:\u00a0<\/td>\nResearch Assistant
Washington University (St. Louis, U.S.A.)\u00a0<\/td>\n<\/tr>\n
1982-1988:\u00a0<\/td>\nHead of Cyclotron Facilities
School of Medicine, Kyoto University
Department of Nuclear Medicine.\u00a0<\/td>\n<\/tr>\n
1988-1996:\u00a0<\/td>\nAssociate Professor
Faculty of Pharmaceutical Sciences, Kyoto University.
Department of Radiopharmaceutical Chemistry.\u00a0<\/td>\n<\/tr>\n
1996-1997:\u00a0<\/td>\nProfessor
Faculty of Pharmaceutical Sciences, Kyoto University.
Department of Radiopharmaceutical Chemistry.\u00a0<\/td>\n<\/tr>\n
1997- present:\u00a0<\/td>\nProfessor
Graduate School of Pharmaceutical Sciences, Kyoto University
Department of Patho-Functional Bioanalysis.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Publication\u00a0List (2006-2011)<\/h2>\n

2011<\/h3>\n
    \n
  1. Shimizu, Y.; Temma, T.; Sano, K.; Ono, M.; Saji, H., Development of membrane type-1 matrix metalloproteinase-specific activatable fluorescent probe for malignant tumor detection. Cancer Sci <\/i>2011<\/b>.<\/li>\n
  2. Mukai, T.; Hagimori, M.; Arimitsu, K.; Katoh, T.; Ukon, M.; Kajimoto, T.; Kimura, H.; Magata, Y.; Miyoshi, E.; Taniguchi, N.; Node, M.; Saji, H., Synthesis and evaluation of a radioiodinated trisaccharide derivative as a synthetic substrate for a sensitive N-acetylglucosaminyltransferase V radioassay. Bioorg Med Chem <\/i>2011,<\/b>19<\/i>(14), 4312-21.<\/li>\n
  3. Cui, M.; Ono, M.; Kimura, H.; Liu, B.; Saji, H., Novel quinoxaline derivatives for in vivo imaging of beta-amyloid plaques in the brain. Bioorg Med Chem Lett <\/i>2011,<\/b> 21<\/i> (14), 4193-6.<\/li>\n
  4. Cui, M.; Ono, M.; Kimura, H.; Liu, B.; Saji, H., Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for beta-amyloid plaques. Bioorg Med Chem <\/i>2011,<\/b> 19<\/i> (13), 4148-53.<\/li>\n
  5. Ono, M.; Saji, H., SPECT Imaging Agents for Detecting Cerebral beta-Amyloid Plaques. Int J Mol Imaging <\/i>2011,<\/b> 2011<\/i>, 543267.<\/li>\n
  6. Masuda, R.; Oishi, S.; Ohno, H.; Kimura, H.; Saji, H.; Fujii, N., Concise site-specific synthesis of DTPA-peptide conjugates: application to imaging probes for the chemokine receptor CXCR4. Bioorg Med Chem <\/i>2011,<\/b> 19<\/i> (10), 3216-20.<\/li>\n
  7. Cui, M.; Ono, M.; Kimura, H.; Kawashima, H.; Liu, B. L.; Saji, H., Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of beta-amyloid plaques in Alzheimer’s disease. Nucl Med Biol <\/i>2011,<\/b> 38<\/i> (3), 313-20.<\/li>\n
  8. Ono, M.; Cheng, Y.; Kimura, H.; Cui, M.; Kagawa, S.; Nishii, R.; Saji, H., Novel 18<\/sup>F-labeled benzofuran derivatives with improved properties for positron emission tomography (PET) imaging of beta-amyloid plaques in Alzheimer’s brains. J Med Chem <\/i>2011,<\/b> 54<\/i> (8), 2971-9.<\/li>\n
  9. Cui, M.; Ono, M.; Kimura, H.; Liu, B.; Saji, H., Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for beta-amyloid plaques. J Med Chem <\/i>2011,<\/b> 54<\/i> (7), 2225-40.<\/li>\n
  10. Makino, A.; Harada, H.; Okada, T.; Kimura, H.; Amano, H.; Saji, H.; Hiraoka, M.; Kimura, S., Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent. Nanomedicine <\/i>2011<\/b>.<\/li>\n
  11. Hagimori, M.; Mizuyama, N.; Yamaguchi, Y.; Saji, H.; Tominaga, Y., A novel small molecule fluorescent sensor for Zn2+<\/sup> based on pyridine-pyridone scaffold. Talanta <\/i>2011,<\/b> 83<\/i> (5), 1730-5.<\/li>\n
  12. Cui, M.; Ono, M.; Kimura, H.; Liu, B. L.; Saji, H., Synthesis and biological evaluation of indole-chalcone derivatives as beta-amyloid imaging probe. Bioorg Med Chem Lett <\/i>2011,<\/b> 21<\/i> (3), 980-2.<\/li>\n
  13. Shono, Y.; Yokota, C.; Kuge, Y.; Kido, S.; Harada, A.; Kokame, K.; Inoue, H.; Hotta, M.; Hirata, K.; Saji, H.; Tamaki, N.; Minematsu, K., Gene expression associated with an enriched environment after transient focal ischemia. Brain Res <\/i>2011,<\/b> 1376<\/i>, 60-5.<\/li>\n
  14. Ono, M.; Watanabe, H.; Watanabe, R.; Haratake, M.; Nakayama, M.; Saji, H., Diphenylpropynone derivatives as probes for imaging beta-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem Lett <\/i>2011,<\/b> 21<\/i> (1), 117-20.<\/li>\n
  15. Shimizu, S.; Atsumi, R.; Nakazawa, T.; Izumi, T.; Sudo, K.; Okazaki, O.; Saji, H., Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model. Arch Toxicol <\/i>2011,<\/b> 85<\/i> (4), 347-53.<\/li>\n
  16. Ueda, M.; Iida, Y.; Yoneyama, T.; Kawai, T.; Ogawa, M.; Magata, Y.; Saji, H., In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: persistent agonist binding inhibits the expression of antiallodynic effects. Synapse <\/i>2011,<\/b> 65<\/i> (1), 77-83.<\/li>\n
  17. Ono M, Hayashi S, Matsumura K, Kimura H, Okamoto Y, Ihara M, Takahashi R, Mori H, Saji H. Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer\u2019s brains. ACS Chem Neurosci<\/i> 2011<\/b>, 2, 269-275.<\/li>\n
  18. Matsumura K, Ono M, Hayashi S, Kimura H, Okamoto Y, Ihara M, Takahashi R, Mori H, Saji H. Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer\u2019s disease brains. Med Chem Comm<\/i> 2011<\/b>, 2, 596-600.<\/li>\n<\/ol>\n

    2010<\/h3>\n
      \n
    1. Sano, K.; Temma, T.; Azuma, T.; Nakai, R.; Narazaki, M.; Kuge, Y.; Saji, H., A Pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast Agents. Mol Imaging Biol <\/i>2010<\/b>.<\/li>\n
    2. Temma, T.; Ogawa, Y.; Kuge, Y.; Ishino, S.; Takai, N.; Nishigori, K.; Shiomi, M.; Ono, M.; Saji, H., Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model. J Nucl Med <\/i>2010,<\/b> 51<\/i> (12), 1979-86.<\/li>\n
    3. Kudo, T.; Ueda, M.; Konishi, H.; Kawashima, H.; Kuge, Y.; Mukai, T.; Miyano, A.; Tanaka, S.; Kizaka-Kondoh, S.; Hiraoka, M.; Saji, H., PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel 18<\/sup>F-Labeled Biotin Derivative. Mol Imaging Biol <\/i>2010<\/b>.<\/li>\n
    4. Sano, K.; Temma, T.; Kuge, Y.; Kudo, T.; Kamihashi, J.; Zhao, S.; Saji, H., Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method. Biol Pharm Bull <\/i>2010,<\/b> 33<\/i> (9), 1589-95.<\/li>\n
    5. Cheng, Y.; Ono, M.; Kimura, H.; Kagawa, S.; Nishii, R.; Saji, H., A novel 18<\/sup>F-labeled pyridyl benzofuran derivative for imaging of beta-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem Lett <\/i>2010,<\/b> 20<\/i> (20), 6141-4.<\/li>\n
    6. Ono, M.; Ikeoka, R.; Watanabe, H.; Kimura, H.; Fuchigami, T.; Haratake, M.; Saji, H.; Nakayama, M., 99m<\/sup>Tc\/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral beta-amyloid plaques. Bioorg Med Chem Lett <\/i>2010,<\/b> 20<\/i> (19), 5743-8.<\/li>\n
    7. Ono, M.; Ishikawa, M.; Kimura, H.; Hayashi, S.; Matsumura, K.; Watanabe, H.; Shimizu, Y.; Cheng, Y.; Cui, M.; Kawashima, H.; Saji, H., Development of dual functional SPECT\/fluorescent probes for imaging cerebral beta-amyloid plaques. Bioorg Med Chem Lett <\/i>2010,<\/b> 20<\/i> (13), 3885-8.<\/li>\n
    8. Kuge, Y.; Takai, N.; Ogawa, Y.; Temma, T.; Zhao, Y.; Nishigori, K.; Ishino, S.; Kamihashi, J.; Kiyono, Y.; Shiomi, M.; Saji, H., Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques. Eur J Nucl Med Mol Imaging <\/i>2010,<\/b> 37<\/i> (11), 2093-104.<\/li>\n
    9. Watanabe, H.; Ono, M.; Haratake, M.; Kobashi, N.; Saji, H.; Nakayama, M., Synthesis and characterization of novel phenylindoles as potential probes for imaging of beta-amyloid plaques in the brain. Bioorg Med Chem <\/i>2010,<\/b> 18<\/i> (13), 4740-6.<\/li>\n
    10. Ueda, M.; Kudo, T.; Kuge, Y.; Mukai, T.; Tanaka, S.; Konishi, H.; Miyano, A.; Ono, M.; Kizaka-Kondoh, S.; Hiraoka, M.; Saji, H., Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha. Eur J Nucl Med Mol Imaging <\/i>2010,<\/b> 37<\/i> (8), 1566-74.<\/li>\n
    11. Ueda, M.; Iida, Y.; Tominaga, A.; Yoneyama, T.; Ogawa, M.; Magata, Y.; Nishimura, H.; Kuge, Y.; Saji, H., Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects. Br J Pharmacol <\/i>2010,<\/b> 159<\/i> (6), 1201-10.<\/li>\n
    12. Zhao, T.; Harada, H.; Teramura, Y.; Tanaka, S.; Itasaka, S.; Morinibu, A.; Shinomiya, K.; Zhu, Y.; Hanaoka, H.; Iwata, H.; Saji, H.; Hiraoka, M., A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells. J Control Release <\/i>2010,<\/b> 144<\/i> (1), 109-14.<\/li>\n
    13. Aita, K.; Temma, T.; Shimizu, Y.; Kuge, Y.; Seki, K.; Saji, H., Synthesis of a new NIR fluorescent Nd complex labeling agent. J Fluoresc <\/i>2010,<\/b> 20<\/i> (1), 225-34.<\/li>\n
    14. Temma, T.; Iida, H.; Hayashi, T.; Teramoto, N.; Ohta, Y.; Kudomi, N.; Watabe, H.; Saji, H.; Magata, Y., Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable 15<\/sup>O-O2<\/sub>. Eur J Nucl Med Mol Imaging <\/i>2010,<\/b> 37<\/i> (2), 377-85.<\/li>\n
    15. Aita, K.; Temma, T.; Kuge, Y.; Seki, K.; Saji, H., NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging. Luminescence <\/i>2010,<\/b> 25<\/i> (1), 19-24.<\/li>\n
    16. Ono M, Ikeoka R, Watanabe H, Kimura H, Fuchigami T, Haratake M, Saji H, Nakayama M. Synthesis and evaluation of novel chalcone derivatives with 99m<\/sup>Tc\/Re complexes as potential probes for detection of beta-amyloid plaques. ACS Chem Neurosci<\/i> 2010<\/b>, 1, 598-607.<\/li>\n
    17. Cheng Y, Ono M, Kimura H, Kagawa S, Nishii R, Kawashima H, Saji H. Fluorinated benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer\u2019s disease brains. ACS Med Chem Lett<\/i> 2010<\/b>, 1, 321-325.<\/li>\n
    18. Ono M, Fuchi Y, Fuchigami T, Kobashi N, Kimura H, Haratake M, Saji H, Nakayama M. Novel benzofurans with 99m<\/sup>Tc complexes as probes for imaging cerebral beta-amyloid plaques using single photon emission computed tomography. ACS Med Chem Lett<\/i> 2010<\/b>, 1, 443-447.<\/li>\n<\/ol>\n

      2009<\/h3>\n
        \n
      1. Ogawa, K.; Kawashima, H.; Kinuya, S.; Shiba, K.; Onoguchi, M.; Kimura, H.; Hashimoto, K.; Odani, A.; Saji, H., Preparation and evaluation of 186\/188<\/sup>Re-labeled antibody (A7) for radioimmunotherapy with rhenium(I) tricarbonyl core as a chelate site. Ann Nucl Med <\/i>2009,<\/b> 23<\/i> (10), 843-8.<\/li>\n
      2. Kuge, Y.; Obokata, N.; Kimura, H.; Katada, Y.; Temma, T.; Sugimoto, Y.; Aita, K.; Seki, K.; Tamaki, N.; Saji, H., Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression. Nucl Med Biol <\/i>2009,<\/b> 36<\/i> (8), 869-76.<\/li>\n
      3. Ono, M.; Watanabe, R.; Kawashima, H.; Cheng, Y.; Kimura, H.; Watanabe, H.; Haratake, M.; Saji, H.; Nakayama, M., Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of beta-amyloid plaques in Alzheimer’s disease. J Med Chem <\/i>2009,<\/b> 52<\/i> (20), 6394-401.<\/li>\n
      4. Ono, M.; Hayashi, S.; Kimura, H.; Kawashima, H.; Nakayama, M.; Saji, H., Push-pull benzothiazole derivatives as probes for detecting beta-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem <\/i>2009,<\/b> 17<\/i> (19), 7002-7.<\/li>\n
      5. Mukai, E.; Toyoda, K.; Kimura, H.; Kawashima, H.; Fujimoto, H.; Ueda, M.; Temma, T.; Hirao, K.; Nagakawa, K.; Saji, H.; Inagaki, N., GLP-1 receptor antagonist as a potential probe for pancreatic beta-cell imaging. Biochem Biophys Res Commun <\/i>2009,<\/b> 389<\/i> (3), 523-6.<\/li>\n
      6. Watanabe, H.; Ono, M.; Ikeoka, R.; Haratake, M.; Saji, H.; Nakayama, M., Synthesis and biological evaluation of radioiodinated 2,5-diphenyl-1,3,4-oxadiazoles for detecting beta-amyloid plaques in the brain. Bioorg Med Chem <\/i>2009,<\/b> 17<\/i> (17), 6402-6.<\/li>\n
      7. Temma, T.; Sano, K.; Kuge, Y.; Kamihashi, J.; Takai, N.; Ogawa, Y.; Saji, H., Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors. Biol Pharm Bull <\/i>2009,<\/b> 32<\/i> (7), 1272-7.<\/li>\n
      8. Kudo, T.; Ueda, M.; Kuge, Y.; Mukai, T.; Tanaka, S.; Masutani, M.; Kiyono, Y.; Kizaka-Kondoh, S.; Hiraoka, M.; Saji, H., Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells. J Nucl Med <\/i>2009,<\/b> 50<\/i> (6), 942-9.<\/li>\n
      9. Saji, H.; Kikuchi, K., [Molecular imaging for acceleration of drug discovery & development and innovation of clinical diagnosis and therapy]. Yakugaku Zasshi <\/i>2009,<\/b> 129<\/i> (3), 263-4.<\/li>\n
      10. Ogawa, M.; Tsukada, H.; Hatano, K.; Ouchi, Y.; Saji, H.; Magata, Y., Central in vivo nicotinic acetylcholine receptor imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT). Biol Pharm Bull <\/i>2009,<\/b> 32<\/i> (3), 337-40.<\/li>\n
      11. Ogawa, K.; Kawashima, H.; Shiba, K.; Washiyama, K.; Yoshimoto, M.; Kiyono, Y.; Ueda, M.; Mori, H.; Saji, H., Development of [90<\/sup>Y]DOTA-conjugated bisphosphonate for treatment of painful bone metastases. Nucl Med Biol <\/i>2009,<\/b> 36<\/i> (2), 129-35.<\/li>\n
      12. Ono, M.; Watanabe, R.; Kawashima, H.; Kawai, T.; Watanabe, H.; Haratake, M.; Saji, H.; Nakayama, M., 18<\/sup>F-labeled flavones for in vivo imaging of beta-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem <\/i>2009,<\/b> 17<\/i> (5), 2069-76.<\/li>\n
      13. Maya, Y.; Ono, M.; Watanabe, H.; Haratake, M.; Saji, H.; Nakayama, M., Novel radioiodinated aurones as probes for SPECT imaging of beta-amyloid plaques in the brain. Bioconjug Chem <\/i>2009,<\/b> 20<\/i> (1), 95-101.<\/li>\n
      14. Ogawa, K.; Mukai, T.; Kawai, K.; Takamura, N.; Hanaoka, H.; Hashimoto, K.; Shiba, K.; Mori, H.; Saji, H., Usefulness of competitive inhibitors of protein binding for improving the pharmacokinetics of 186<\/sup>Re-MAG3-conjugated bisphosphonate (186<\/sup>Re-MAG3-HBP), an agent for treatment of painful bone metastases. Eur J Nucl Med Mol Imaging <\/i>2009,<\/b> 36<\/i> (1), 115-21.<\/li>\n<\/ol>\n

        2008<\/h3>\n
          \n
        1. Ishino, S.; Mukai, T.; Kuge, Y.; Kume, N.; Ogawa, M.; Takai, N.; Kamihashi, J.; Shiomi, M.; Minami, M.; Kita, T.; Saji, H., Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99m<\/sup>Tc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque. J Nucl Med <\/i>2008,<\/b> 49<\/i> (10), 1677-85.<\/li>\n
        2. Doue, T.; Ohtsuki, K.; Ogawa, K.; Ueda, M.; Azuma, A.; Saji, H.; Strauss, H. W.; Matsubara, H., Cardioprotective effects of erythropoietin in rats subjected to ischemia-reperfusion injury: assessment of infarct size with 99m<\/sup>Tc-annexin V. J Nucl Med <\/i>2008,<\/b> 49<\/i> (10), 1694-700.<\/li>\n
        3. Kuge, Y.; Kume, N.; Ishino, S.; Takai, N.; Ogawa, Y.; Mukai, T.; Minami, M.; Shiomi, M.; Saji, H., Prominent lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits. Biol Pharm Bull <\/i>2008,<\/b> 31<\/i> (8), 1475-82.<\/li>\n
        4. Ono, M.; Haratake, M.; Saji, H.; Nakayama, M., Development of novel beta-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole. Bioorg Med Chem <\/i>2008,<\/b> 16<\/i> (14), 6867-72.<\/li>\n
        5. Temma, T.; Kuge, Y.; Sano, K.; Kamihashi, J.; Obokata, N.; Kawashima, H.; Magata, Y.; Saji, H., PET O-15 cerebral blood flow and metabolism after acute stroke in spontaneously hypertensive rats. Brain Res <\/i>2008,<\/b> 1212<\/i>, 18-24.<\/li>\n
        6. Kiyono, Y.; Sugita, T.; Ueda, M.; Kawashima, H.; Kanegawa, N.; Kuge, Y.; Fujibayashi, Y.; Saji, H., Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart. Nucl Med Biol <\/i>2008,<\/b> 35<\/i> (2), 213-8.<\/li>\n
        7. Saji, H., [Application of radiometallic compounds for medical diagnosis and therapy]. Yakugaku Zasshi <\/i>2008,<\/b> 128<\/i> (3), 323-32.<\/li>\n
        8. Ueda, M.; Iida, Y.; Kitamura, Y.; Kawashima, H.; Ogawa, M.; Magata, Y.; Saji, H., 5-Iodo-A-85380, a specific ligand for alpha 4 beta 2 nicotinic acetylcholine receptors, prevents glutamate neurotoxicity in rat cortical cultured neurons. Brain Res <\/i>2008,<\/b> 1199<\/i>, 46-52.<\/li>\n
        9. Kotsuma, M.; Tokui, T.; Ishizuka-Ozeki, T.; Honda, T.; Iwabuchi, H.; Murai, T.; Ikeda, T.; Saji, H., CYP2D6-Mediated metabolism of a novel acyl coenzyme A:cholesterol acyltransferase inhibitor, pactimibe, and its unique plasma metabolite, R-125528. Drug Metab Dispos <\/i>2008,<\/b> 36<\/i> (3), 529-34.<\/li>\n
        10. Takatsuka, S.; Morita, T.; Horikiri, Y.; Yamahara, H.; Saji, H., Influence of various combinations of mucolytic agent and non-ionic surfactant on intestinal absorption of poorly absorbed hydrophilic compounds. Int J Pharm <\/i>2008,<\/b> 349<\/i> (1-2), 94-100.<\/li>\n<\/ol>\n

          2007<\/h3>\n
            \n
          1. Akizawa, H.; Saito, M.; Tsukamoto, I.; Ohkura, T.; Shimizu, T.; Kitamura, Y.; Mifune, M.; Saito, Y.; Arano, Y.; Saji, H., Effect of carboxyl-group of D-glutamic acid or gamma-carboxy-D-glutamic acid as N-terminal amino acid of 111<\/sup>In-diethylenetriaminepentaacetic acid-octreotide on accumulation of radioactivity in kidney. Biol Pharm Bull <\/i>2007,<\/b> 30<\/i> (11), 2226-8.<\/li>\n
          2. Mamede, M.; Ishizu, K.; Ueda, M.; Mukai, T.; Iida, Y.; Kawashima, H.; Fukuyama, H.; Togashi, K.; Saji, H., Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study. J Nucl Med <\/i>2007,<\/b> 48<\/i> (11), 1829-35.<\/li>\n
          3. Kuge, Y.; Takai, N.; Ishino, S.; Temma, T.; Shiomi, M.; Saji, H., Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atherosclerosis: comparison with plaque instability analysis. Biol Pharm Bull <\/i>2007,<\/b> 30<\/i> (9), 1634-40.<\/li>\n
          4. Kiyono, Y.; Kuge, Y.; Katada, Y.; Kawashima, H.; Magata, Y.; Saji, H., Applicability of a high-resolution small semiconductor gamma camera to small animal imaging. Nucl Med Commun <\/i>2007,<\/b> 28<\/i> (9), 736-41.<\/li>\n
          5. Aita, K.; Temma, T.; Kuge, Y.; Saji, H., Development of a novel neodymium compound for in vivo fluorescence imaging. Luminescence <\/i>2007,<\/b> 22<\/i> (5), 455-61.<\/li>\n
          6. Hanaoka, H.; Mukai, T.; Habashita, S.; Asano, D.; Ogawa, K.; Kuroda, Y.; Akizawa, H.; Iida, Y.; Endo, K.; Saga, T.; Saji, H., Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors. Nucl Med Biol <\/i>2007,<\/b> 34<\/i> (5), 503-10.<\/li>\n
          7. Oishi, N.; Hashikawa, K.; Yoshida, H.; Ishizu, K.; Ueda, M.; Kawashima, H.; Saji, H.; Fukuyama, H., Quantification of nicotinic acetylcholine receptors in Parkinson’s disease with 123<\/sup>I-5IA SPECT. J Neurol Sci <\/i>2007,<\/b> 256<\/i> (1-2), 52-60.<\/li>\n
          8. Takatsuka, S.; Morita, T.; Horikiri, Y.; Yamahara, H.; Saji, H., Absorption enhancement of poorly absorbed hydrophilic compounds from various mucosal sites by combination of mucolytic agent and non-ionic surfactant. Int J Pharm <\/i>2007,<\/b> 338<\/i> (1-2), 87-93.<\/li>\n
          9. Saji, H., [Molecular imaging in evaluation of in vivo behavior of drugs]. Nippon Rinsho <\/i>2007,<\/b> 65<\/i> (2), 363-9.<\/li>\n
          10. Ishino, S.; Mukai, T.; Kume, N.; Asano, D.; Ogawa, M.; Kuge, Y.; Minami, M.; Kita, T.; Shiomi, M.; Saji, H., Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability–analysis in hypercholesterolemic rabbits. Atherosclerosis <\/i>2007,<\/b> 195<\/i> (1), 48-56.<\/li>\n
          11. Ishino, S.; Kuge, Y.; Takai, N.; Tamaki, N.; Strauss, H. W.; Blankenberg, F. G.; Shiomi, M.; Saji, H., 99m<\/sup>Tc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits. Eur J Nucl Med Mol Imaging <\/i>2007,<\/b> 34<\/i> (6), 889-99.<\/li>\n
          12. Ogawa, K.; Mukai, T.; Asano, D.; Kawashima, H.; Kinuya, S.; Shiba, K.; Hashimoto, K.; Mori, H.; Saji, H., Therapeutic effects of a 186<\/sup>Re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model. J Nucl Med <\/i>2007,<\/b> 48<\/i> (1), 122-7.<\/li>\n
          13. Kiyono, Y.; Yamashita, T.; Doi, H.; Kuge, Y.; Katsura, T.; Inui, K.; Saji, H., Is MIBG a substrate of P-glycoprotein? Eur J Nucl Med Mol Imaging <\/i>2007,<\/b> 34<\/i> (4), 448-52.<\/li>\n<\/ol>\n

            2006<\/h3>\n
              \n
            1. Ogawa, K.; Mukai, T.; Inoue, Y.; Ono, M.; Saji, H., Development of a novel 99m<\/sup>Tc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent. J Nucl Med <\/i>2006,<\/b> 47<\/i> (12), 2042-7.<\/li>\n
            2. Ogawa, M.; Magata, Y.; Kato, T.; Hatano, K.; Ishino, S.; Mukai, T.; Shiomi, M.; Ito, K.; Saji, H., Application of 18<\/sup>F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques. J Nucl Med <\/i>2006,<\/b> 47<\/i> (11), 1845-50.<\/li>\n
            3. Ogawa, K.; Mukai, T.; Arano, Y.; Otaka, A.; Ueda, M.; Uehara, T.; Magata, Y.; Hashimoto, K.; Saji, H., Rhemium-186-monoaminemonoamidedithiol-conjugated bisphosphonate derivatives for bone pain palliation. Nucl Med Biol <\/i>2006,<\/b> 33<\/i> (4), 513-20.<\/li>\n
            4. Hanaoka, H.; Mukai, T.; Tamamura, H.; Mori, T.; Ishino, S.; Ogawa, K.; Iida, Y.; Doi, R.; Fujii, N.; Saji, H., Development of a 111<\/sup>In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors. Nucl Med Biol <\/i>2006,<\/b> 33<\/i> (4), 489-94.<\/li>\n
            5. Kitamura, Y.; Iida, Y.; Abe, J.; Mifune, M.; Kasuya, F.; Ohta, M.; Igarashi, K.; Saito, Y.; Saji, H., Release of vesicular Zn2+<\/sup> in a rat transient middle cerebral artery occlusion model. Brain Res Bull <\/i>2006,<\/b> 69<\/i> (6), 622-5.<\/li>\n
            6. Shikano, N.; Nakajima, S.; Kotani, T.; Itoh, Y.; Nishii, R.; Yoshimoto, M.; Flores, L. G., 2nd; Saji, H.; Ishikawa, N.; Kawai, K., Detection of maleate-induced Fanconi syndrome by decreasing accumulation of 125<\/sup>I-3-iodo-alpha-methyl-L-tyrosine in the proximal tubule segment-1 region of renal cortex in mice: a trial of separate evaluation of reabsorption. Ann Nucl Med <\/i>2006,<\/b> 20<\/i> (3), 175-81.<\/li>\n
            7. Hosokawa, R.; Kambara, N.; Ohba, M.; Mukai, T.; Ogawa, M.; Motomura, H.; Kume, N.; Saji, H.; Kita, T.; Nohara, R., A catheter-based intravascular radiation detector of vulnerable plaques. J Nucl Med <\/i>2006,<\/b> 47<\/i> (5), 863-7.<\/li>\n
            8. Ono, M.; Kawashima, H.; Nonaka, A.; Kawai, T.; Haratake, M.; Mori, H.; Kung, M. P.; Kung, H. F.; Saji, H.; Nakayama, M., Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer’s disease brains. J Med Chem <\/i>2006,<\/b> 49<\/i> (9), 2725-30.<\/li>\n
            9. Kitamura, Y.; Iida, Y.; Abe, J.; Mifune, M.; Kasuya, F.; Ohta, M.; Igarashi, K.; Saito, Y.; Saji, H., In vivo measurement of presynaptic Zn2+<\/sup> release during forebrain ischemia in rats. Biol Pharm Bull <\/i>2006,<\/b> 29<\/i> (4), 821-3.<\/li>\n
            10. Temma, T.; Magata, Y.; Kuge, Y.; Shimonaka, S.; Sano, K.; Katada, Y.; Kawashima, H.; Mukai, T.; Watabe, H.; Iida, H.; Saji, H., Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable15<\/sup>O-O2<\/sub>. J Cereb Blood Flow Metab <\/i>2006,<\/b> 26<\/i> (12), 1577-83.<\/li>\n
            11. Ogawa, M.; Iida, Y.; Nakagawa, M.; Kuge, Y.; Kawashima, H.; Tominaga, A.; Ueda, M.; Magata, Y.; Saji, H., Change of central cholinergic receptors following lesions of nucleus basalis magnocellularis in rats: search for an imaging index suitable for the early detection of Alzheimer’s disease. Nucl Med Biol <\/i>2006,<\/b> 33<\/i> (2), 249-54.<\/li>\n
            12. Kanegawa, N.; Kiyono, Y.; Kimura, H.; Sugita, T.; Kajiyama, S.; Kawashima, H.; Ueda, M.; Kuge, Y.; Saji, H., Synthesis and evaluation of radioiodinated (S,S)-2-(alpha-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter. Eur J Nucl Med Mol Imaging <\/i>2006,<\/b> 33<\/i> (6), 639-47.<\/li>\n
            13. Kitamura, Y.; Iida, Y.; Abe, J.; Ueda, M.; Mifune, M.; Kasuya, F.; Ohta, M.; Igarashi, K.; Saito, Y.; Saji, H., Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model. J Pharmacol Sci <\/i>2006,<\/b> 100<\/i> (2), 142-8.<\/li>\n
            14. Fukumitsu, N.; Suzuki, M.; Fukuda, T.; Kiyono, Y.; Kajiyama, S.; Saji, H., Reduced 125<\/sup>I-meta-iodobenzylguanidine uptake and norepinephrine transporter density in the hearts of mice with MPTP-induced parkinsonism. Nucl Med Biol <\/i>2006,<\/b> 33<\/i> (1), 37-42.<\/li>\n
            15. Kuge, Y.; Katada, Y.; Shimonaka, S.; Temma, T.; Kimura, H.; Kiyono, Y.; Yokota, C.; Minematsu, K.; Seki, K.; Tamaki, N.; Ohkura, K.; Saji, H., Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression. Nucl Med Biol <\/i>2006,<\/b> 33<\/i> (1), 21-7.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

              Hideo Saji, Ph.D. Department of Patho-Functional BioanalysisProfessor Kyoto UniversityGraduate School of Pharm […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":30,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-noindent.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-334","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/comments?post=334"}],"version-history":[{"count":2,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/334\/revisions"}],"predecessor-version":[{"id":1156,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/334\/revisions\/1156"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/pages\/30"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/byotai\/wp-json\/wp\/v2\/media?parent=334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}