{"id":3162,"date":"2012-11-21T15:53:06","date_gmt":"2012-11-21T06:53:06","guid":{"rendered":"http:\/\/www.pharm.kyoto-u.ac.jp\/?page_id=3162"},"modified":"2025-05-23T14:44:16","modified_gmt":"2025-05-23T05:44:16","slug":"ps","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/research\/research-organization\/research-profile\/ps\/","title":{"rendered":"Division of Pharmaceutical Sciences"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n\n
Departments Leaders<\/th>\nResearch Fields<\/th>\nResearch Profile<\/th>\n<\/tr>\n
Synthetic Medicinal Chemistry
\n<\/a>Professor
\nKiyosei TAKASU<\/td>\n		\n
    \n
  1. Synthesis of Biologically Active Molecules<\/li>\n
  2. Development of New Synthetic Methodology for Complex Molecules<\/li>\n
  3. Molecular Architecture of Unique Organic Materials<\/li>\n
  4. Chemistry of Strained Molecules<\/li>\n
  5. Control of Molecular Dynamism<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Organic Chemistry
\n<\/a>Professor
\nYoshiji TAKEMOTO<\/td>\n		\n
    \n
  1. Design of environmentally friendly organocatalysts for process chemistry<\/li>\n
  2. Development of new reagents and synthetic methods using unique elements.<\/li>\n
  3. Total synthesis of biologically important synthetic and natural products<\/li>\n
  4. Molecular modification using multi-functional heterocycles<\/li>\n
  5. Innovative catalysts for large- and medium-sized glycopeptides<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Biophysical Chemistry<\/a>
\nAssociate Professor
\nMasaru HOSHINO<\/td>\n		\n
    \n
  1. Elucidation of the action mechanisms of antimicrobial peptides<\/li>\n
  2. Initiation mechanism of Alzheimer\u2019s disease<\/li>\n
  3. Elucidation of membrane protein folding<\/li>\n
  4. Regulation of function of G-protein coupled receptors<\/li>\n
  5. Protein structure determination by NMR<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Structural Biology
\n<\/a>Professor
\nHiroaki KATO<\/td>\n		\n
    \n
  1. Structural-basis for pharmacologic behaviour of ATP binding Cassette transporters<\/li>\n
  2. Development of a new technique of X-ray crystallography by X-ray free electron laser<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Molecular and Cellular Bioanalysis
\n<\/a>Professor
\nYasushi ISHIHAMA<\/td>\n		\n
    \n
  1. Development of novel analytical technologies for proteomics<\/li>\n
  2. Functional analysis of human proteomes by high resolution LC\/MS\/MS<\/li>\n
  3. Elucidation of intracellular phosphorylation network analysis<\/li>\n
  4. Intelligent proteome analysis by biomolecular mass spectrometry integrated with statistical signal processing<\/li>\n
  5. Metaproteome analysis of microbiomes in human diseases.<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Biological Chemistry
\nProfessor
\nHiroshi TAKESHIMA<\/td>\n		\n
    \n
  1. Ca2+<\/sup> signaling from intracellular stores<\/li>\n
  2. Novel signaling in central nervous system<\/li>\n
  3. Structure and function of muscle membrane systems<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Cell Fate Dynamics and Therapeutics<\/p>\n

Professor
\nTakahiro ITO<\/td>\n

\n
    \n
  1. Regulatory mechanisms of cell fates in stem cells and cancer<\/li>\n
  2. Metabolic regulation of cancer cell fates in leukemia<\/li>\n
  3. Cell fate regulation by RNA binding proteins in myogenesis and muscle functions<\/li>\n
  4. Drug discovery and modulation of cell fates as therapeutic strategies in human malignancies<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
\n
Genetics<\/a><\/pre>\n
Professor
\nTatsushi IGAKI<\/td>\n
\n
    \n
  1. Mechanism of cell competition<\/li>\n
  2. Genetic basis of tissue growth regulation<\/li>\n
  3. Molecular basis of tumor progression and metastasis<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Molecular Neurobiology<\/a>
\nProfessorIkuo KIMURA<\/td>\n		\n
    \n
  1. Signal transduction pathways involved in cancer progression.<\/li>\n
  2. Regulation of amino acid metabolism in cancer cells.<\/li>\n<\/ol>\n<\/td>\n
<\/td>\n<\/tr>\n
Biofunctional Chemistry<\/a><\/p>\n
Associate Professor<\/span><\/pre>\n
Miki IMANISHI<\/td>\n
\n
    \n
  1. Creation of bioactive proteins that control cell function and genes<\/li>\n
  2. Development of peptide-based intracellular delivery systems for biomacromolecules<\/li>\n
  3. Design of peptides and proteins that induce membrane curvature<\/li>\n
  4. Design of artificial transcription factors that regulate gene expression<\/li>\n
  5. Assembly control of membrane proteins and the regulation of biological signals<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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