{"id":4085,"date":"2021-06-01T00:00:00","date_gmt":"2021-05-31T15:00:00","guid":{"rendered":"http:\/\/www.pharm.kyoto-u.ac.jp\/research\/research-profile\/bioinformatics-and-chemical-genomics\/"},"modified":"2021-06-01T07:02:36","modified_gmt":"2021-05-31T22:02:36","slug":"bcg","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/research\/research-organization\/research-profile\/bcg\/","title":{"rendered":"Division of Bioinformatics and Chemical Genomics"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n
Departments Leaders<\/th>\nResearch Fields<\/th>\nResearch Profile<\/th>\n<\/tr>\n
Pharmacogenomics \/ Genomic Drug Discovery
\nAssociate Professor
\nAkira HIRASAWA<\/td>\n		\n
    \n
  1. Discovery of novel drug target and its validation by integrative genome science<\/li>\n
  2. In Silico drug discover and design by bioinformatics<\/li>\n
  3. Ligand fishing of \u201corphan G-protein-coupled receptors\u201d and structure-function analysis<\/li>\n
  4. Functional genomic study using transgenic\/knockout animals<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Chemogenomics \/ Bioorganic Medicinal Chemistry
\n<\/a>Professor
\nHiroaki OHNO<\/td>\n		\n
    \n
  1. Synthesis of structurally complex bioactive compounds<\/li>\n
  2. Novel methods for the synthesis of complex structures and their applications<\/li>\n
  3. Identification of functional molecules based on designs, synthetic studies and chemical modifications of biomolecules<\/li>\n
  4. Development of a novel screening platform using synthetic peptides and proteins<\/li>\n
  5. Drug screening programs using in-house chemical libraries<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Systems Biology
\n<\/a>Professor
\nMasao DOI<\/td>\n		\n
    \n
  1. Molecular mechanisms of circadian time systems in mammals<\/li>\n
  2. Circadian brain G-protein coupled receptor signaling for sleep and metabolism<\/li>\n
  3. Molecular mechanisms of ageing-associated circadian rhythm disorders<\/li>\n
  4. Translational research on circadian time-associated lifestyle diseases<\/li>\n
  5. Development of new drugs for tuning circadian time systems<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
System Chemotherapy and Molecular Sciences
\nProfessor
\nHideaki KAKEYA<\/td>\n		\n
    \n
  1. Advanced chemical biology research for establishing system chemotherapy in order to cure
    \nmulti-factorial diseases; e.g. cancer, infectious diseases, heart failure, immunodeficiency,
    \ndiabetes, and neuronal diseases<\/li>\n
  2. HCS (high-contents screening) and HTS (high throughput screening) for identifying useful
    \nsmall molecules (bioprobes)<\/li>\n
  3. Natural product chemistry and medicinal chemistry for mining novel bioactive small\u3000molecules<\/li>\n
  4. Biosynthetic studies of natural products and their application to combinatorial biosynthesis<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Integrative Genomics<\/a><\/p>\n

Professor
\nHiroyuki OGATA<\/td>\n

\n
    \n
  1. Genomics of viruses<\/li>\n
  2. Interactions between microbial communities and their environments<\/li>\n
  3. Integration of chemical, genomics, and biomedical knowledge for drug discovery and environmental preservation<\/li>\n<\/ol>\n<\/td>\n
\"\"<\/a><\/td>\n<\/tr>\n
Chemical Biology<\/a><\/p>\n

Professor
\nMotonari UESUGI<\/td>\n

\n
    \n
  1. In-depth analysis of human cells through organic-chemistry approaches<\/li>\n
  2. Exogenous control of human cells with synthetic compounds<\/li>\n
  3. Development of novel methods for discovering and using bioactive compounds<\/li>\n
  4. Discovery and design of self-assembling bioactive molecules and intracellular self-assemblies<\/li>\n
  5. Understanding of intracellular chemical signalings mediated by radical reactions<\/li>\n<\/ol>\n<\/td>\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Departments Leaders Research Fields Research Profile Pharmacogenomics \/ Genomic Drug Discovery Associate Profe […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3157,"menu_order":48,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"class_list":["post-4085","page","type-page","status-publish","hentry"],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/4085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=4085"}],"version-history":[{"count":5,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/4085\/revisions"}],"predecessor-version":[{"id":21528,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/4085\/revisions\/21528"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/3157"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=4085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}