{"id":16,"date":"2019-09-28T09:47:34","date_gmt":"2019-09-28T00:47:34","guid":{"rendered":"https:\/\/testwebcil2.com\/takikawa\/?page_id=16"},"modified":"2026-04-02T15:30:59","modified_gmt":"2026-04-02T06:30:59","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<h3 id=\"1\">Original Papers<\/h3>\n<h4>2026<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>One-Pot Multi-Substrate Screening of Ligation Reactions Using PNA Tags<\/b><br \/>Kohyama, A.; Barluenga, S.; Winssinger, N.<br \/><I>Chem. Sci.<\/i>\u00a0<b>2026<\/b>, <em>xxx<\/em>, xxx-xxx. <br \/><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2026\/sc\/d5sc08732e\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/d5sc08732e<\/a>\n<ul>\n<li><b>Toward N-Linked Glycoproteins: Three-Step Synthesis of Glycan-Asparagine Conjugates from Unprotected Sugars<\/b><br \/>Akeno, J.; Takasu, K.; Oisaki, K.; Kumada-Nozawa, K.; Sada, H.; Nanjo, T.; Fukaya, N.; Ueda, Y.<br \/><I>Org. Lett.<\/i>\u00a0<b>2026<\/b>, <em>28<\/em>, 3441-3447. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.6c00314\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.6c00314<\/a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2026\/03\/akeno.jpg\" alt=\"\" width=\"1000\" height=\"457\" class=\"aligncenter size-full wp-image-1663\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2026\/03\/akeno.jpg 1000w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2026\/03\/akeno-300x137.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2026\/03\/akeno-768x351.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/>\n<li><b>Self-Induced Charge Transfer Activation Enables Metal-Free C\u2013H Coupling of Polycyclic Aromatic Hydrocarbons under Photo Irradiation<\/b><br \/>Kurokawa, K.; Kohyama, A.; Kuroda, Y.; Tao-Kakuyama, K.; Takikawa, H.; Takasu, K.<br \/><I>Chem. Sci.<\/i>\u00a0<b>2026<\/b>, <em>17<\/em>, 4942-4947. <br \/><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2026\/sc\/d5sc09144f\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/d5sc09144f<\/a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2026\/03\/kurokawa.png\" alt=\"\" width=\"826\" height=\"322\" class=\"aligncenter size-full wp-image-1664\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2026\/03\/kurokawa.png 826w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2026\/03\/kurokawa-300x117.png 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2026\/03\/kurokawa-768x299.png 768w\" sizes=\"auto, (max-width: 826px) 100vw, 826px\" \/>\n<ul>\n<div>\n<h4>2025<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Synthesis and Properties of Medium-Sized cis,trans-Cycloocta-1,3-diene\u2013Pt(II) Complexes<\/b><br \/>Kinouchi, H.; Ito, T.; Kohyama, A.; Kuroda, Y.; Takikawa, H.; Takasu, K.<br \/><I>Org. Lett.<\/i>\u00a0<b>2025<\/b>, <em>27<\/em>, 13922-13927. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.5c04468\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.5c04468<\/a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/12\/kinouchi-OL.jpg\" alt=\"\" width=\"693\" height=\"246\" class=\"aligncenter size-full wp-image-1650\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/12\/kinouchi-OL.jpg 693w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/12\/kinouchi-OL-300x106.jpg 300w\" sizes=\"auto, (max-width: 693px) 100vw, 693px\" \/>\n<li><b>Net \u03b4-C\u2013H Alkylation of Allyl Alcohols by Ni-Catalyzed Allylic Substitution of Azo-Ene Adducts<\/b><br \/>Kawajiri, M.; Kuroda, Y.; Takasu, K.<br \/><I>J. Org. Chem.<\/i>\u00a0<b>2025<\/b>, <em>90<\/em>, 12826-12831. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.5c01497\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.joc.5c01497<\/a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/08\/Kawajiri-Ni.png\" alt=\"\" width=\"502\" height=\"235\" class=\"aligncenter size-full wp-image-1625\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/08\/Kawajiri-Ni.png 502w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/08\/Kawajiri-Ni-300x140.png 300w\" sizes=\"auto, (max-width: 502px) 100vw, 502px\" \/>\n<li><b>A Potassium Base-Promoted Intramolecular Enolate\u2013Olefin Metathesis<\/b><br \/>Sugimoto, K.; Nagao, T.; Kurokawa, K.; Tawatari, T.; Miyakawa, Y.; Fujimura, S.; Yamada, K.; Yamaoka, Y.; Kohyama, A.; Kuroda, Y.; Takikawa, H.; Takasu, K.<br \/><I>Chem. Eur. J.<\/i>\u00a0<b>2025<\/b>, <em>31<\/em>, e00737. <br \/><a href=\"https:\/\/doi.org\/10.1002\/chem.202500737\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/chem.202500737<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/08\/Nagao.jpg\" alt=\"\" width=\"512\" height=\"157\" class=\"aligncenter size-full wp-image-1606\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/08\/Nagao.jpg 394w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/08\/Nagao-300x92.jpg 300w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/p>\n<li><b>Unveiling the Inverse-Handed Self-Discrimination of Helicenes with Twisted \u03c0-Surfaces by Liquid Chromatography<\/b><br \/>Kanao, E.; Murata, Y.; Miwa, S.; Takikawa, H.; Takasu, K.; Ishihama, Y.; Kubo, T.<br \/><I>Anal. Chem.<\/i>\u00a0<b>2025<\/b>, <em>97<\/em>, 12690-12698. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01385\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.analchem.5c01385<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/07\/Kanao-Miwa.gif\" alt=\"\" width=\"500\" height=\"335\" class=\"aligncenter size-full wp-image-1603\" \/><\/p>\n<li><b>Arylative Double Bond Transposition of Allylic Alcohols via Silicon-Tethered Intramolecular Benzyne\u2013Ene Reactions<\/b><br \/>Kato, R.; Sakaue, T.; Tawatari, T.; Takasu, K.; Takikawa, H.<br \/><I>Chem. Commun.<\/i>\u00a0<b>2025<\/b>, <em>61<\/em>, 8347-8350. <br \/><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2025\/cc\/d5cc01918d\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/D5CC01918D<\/a> <br \/> <span class=\"red\">Selected as <a href=\"https:\/\/pubs.rsc.org\/en\/journals\/articlecollectionlanding?sercode=cc&amp;themeid=8b2e2ae6-53c6-4f00-a2e9-9edf507e75f0\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">Chemical Communications HOT articles 2025<\/a><\/span><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/05\/P2025_4_Kato.jpg\" alt=\"\" width=\"110%\" height=\"110%\" class=\"aligncenter size-full wp-image-858\" \/><\/p>\n<li><b>Pd-Catalyzed Allylic Substitution of Azo-Ene Adducts Enables Net Allylic C\u2013H Alkylation of Allylic Alcohols<\/b><br \/>Kuroda, Y.; Chiba, T.; Kawajiri, M.; Takasu, K.<br \/><I>Org. Lett.<\/i>\u00a0<b>2025<\/b>, <em>27<\/em>, 1517-1523. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.5c00049\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.5c00049<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/chiba-TOC.png\" alt=\"\" width=\"80%\" height=\"80%\" class=\"aligncenter size-full wp-image-1515\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/chiba-TOC.png 664w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/chiba-TOC-300x118.png 300w\" sizes=\"(max-width: 664px) 100vw, 664px\" \/><\/p>\n<li><b>Helicene\u2013Fluorescein Hybrids: A Reversible Base-triggered (Chir)optical Switch with Sign Inversion of Circularly Polarized Luminescence<\/b><br \/>Miwa, S.; Mizutani, D.; Kawano, K.; Matsuzaki, K.; Nagata, Y.; Tsubaki, K.; Takasu, K.; Takikawa, H.<br \/><I>Chem. Eur. J.<\/i>\u00a0<b>2025<\/b>, <em>31<\/em>, e202500335. <br \/><a href=\"https:\/\/doi.org\/10.1002\/chem.202500335\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/chem.202500335<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/miwa-TOC.jpg\" alt=\"\" width=\"90%\" height=\"90%\" class=\"aligncenter size-full wp-image-1507\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/miwa-TOC.jpg 1618w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/miwa-TOC-300x88.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/miwa-TOC-1024x299.jpg 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/miwa-TOC-768x225.jpg 768w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/miwa-TOC-1536x449.jpg 1536w\" sizes=\"(max-width: 1618px) 100vw, 1618px\" \/><\/p>\n<li><b>Continuous Flow Synthesis of Cyclobutenes via Lithium Ynolates<\/b><br \/>Kohyama, A.; Namioka, M.; Naka, H.; Ashikari, Y.; Nagaki, A.; Takikawa, H.; Yamaoka, Y.; Takasu, K.<br \/><I>Green Chem.<\/i>\u00a0<b>2025<\/b>, <em>27<\/em>, 2760-2765. <br \/><a href=\"https:\/\/doi.org\/10.1039\/D4GC05102E\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/D4GC05102E<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/koyama-GA.png\" alt=\"\" width=\"85%\" height=\"85%\" class=\"aligncenter size-full wp-image-1508\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/koyama-GA.png 950w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/koyama-GA-300x164.png 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2025\/02\/koyama-GA-768x420.png 768w\" sizes=\"(max-width: 950px) 100vw, 950px\" \/>\n<\/ul>\n<\/div>\n<h4>2024<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Synthetic Study towards Providencin: Stereocontrolled Synthesis of the Furan-Substituted Cyclobutanol Segment<\/b><br \/>Yamaoka, Y.; Nishina, R.; Fujita, K.; Takasu, K.<br \/><I>Chem. Pharm. Bull.<\/i>\u00a0<b>2024<\/b>, <em>72<\/em>, 966-969. <br \/><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/72\/11\/72_c24-00629\/_article\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1248\/cpb.c24-00629<\/a> <br \/><span class=\"red\">Selected as a featured article<\/span><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/11\/providencin.png\" alt=\"\" width=\"80%\" height=\"80%\" class=\"aligncenter size-medium wp-image-1462\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/11\/providencin.png 450w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/11\/providencin-300x99.png 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/p>\n<li><b>Stable and Minimum Size Solubilization of Membrane Proteins with Cocktails of Phospholipid Analogues<\/b><br \/>Takagi, M.; Nagatani, A.; Kawano, K.; Hata, A.; Yokoyama, A.; Hayashida, K.; Hoshi, H.; Sakurai, M.; Oyama, T.; Kuroda, Y.; Yamaoka, Y.; Fujiwara, T.; Miyanoiri, Y.; Hoshino, M.; Yano, Y.; Takasu, K.; Matsuzaki, K<br \/><I>ACS Appl. Mater. Interfaces<\/i>\u00a0<b>2024<\/b>, <em>16<\/em>, 63358-63367. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acsami.4c15697\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acsami.4c15697<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/11\/Matsuzaki.png\" alt=\"\" width=\"70%\" height=\"70%\" class=\"aligncenter size-medium wp-image-1461\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/11\/Matsuzaki.png 1002w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/11\/Matsuzaki-300x137.png 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/11\/Matsuzaki-768x351.png 768w\" sizes=\"(max-width: 1002px) 100vw, 1002px\" \/><\/p>\n<li><b>Photo-Induced Pyridylic C(sp3)\u2013H Alkylation with Unactivated Alkenes Enabled by Hydrogen Atom Transfer\/Lewis Acid Cocatalysis<\/b><br \/>Kuroda, Y.; Saito, H.; Tawatari, T.;  Takasu, K.<br \/><I>ACS Catal.<\/i>\u00a0<b>2024<\/b>, <em>14<\/em>, 15036-15042. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acscatal.4c05026\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acscatal.4c05026<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/09\/saito-pyridine.png\" alt=\"\" width=\"500\" height=\"370\" class=\"aligncenter size-medium wp-image-1413\" \/><\/p>\n<li><b>Chromic Properties of Dibenzo[<I>j,l<\/i>]fluoranthenes Exhibiting Different Resonance Contributions<\/b><br \/>Kurokawa, K.; Ogawa, N.; Kuroda, Y.; Yamaoka, Y.; Takikawa, H.; Tsubaki, K.; Takasu, K.<br \/><I>Org. Biomol. Chem.<\/i>\u00a0<b>2024<\/b>, <em>22<\/em>, 5306-5313. <br \/><a href=\"https:\/\/doi.org\/10.1039\/D4OB00750F\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/D4OB00750F<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/06\/cover_takasu-300x222.jpg\" alt=\"\" width=\"300\" height=\"222\" class=\"aligncenter size-medium wp-image-1413\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/06\/cover_takasu-300x222.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/06\/cover_takasu-1024x757.jpg 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/06\/cover_takasu-768x568.jpg 768w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/06\/cover_takasu-1536x1136.jpg 1536w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/06\/cover_takasu-2048x1515.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<li><b>Entry into Lithium Ynolates from \u03b1,\u03b1,\u03b1-Tribromomethyl Ketones: Synthesis of Cyclobutenes via the [2 + 2] Cycloaddition with \u03b1,\u03b2-Unsaturated Carbonyls<\/b><br \/>Yamaoka, Y.; Imahori, H.; Namioka, M.; Nishina, R.; Kobori, Y.; Ueda, M.; Shindo, M.; Takasu, K.<br \/><I>Org. Lett.<\/i>\u00a0<b>2024<\/b>, <em>26<\/em>, 1986-1901. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.4c00202\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.4c00202<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/03\/P2024_3_Yamaoka.jpg\" alt=\"\" width=\"75%\" height=\"75%\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Structure\u2013ATPase Activity Relationship of Rhodamine Derivatives as Potent Inhibitors of P-Glycoprotein CmABCB1<\/b><br \/>Miwa, S.; Takikawa, H.; Takeuchi, R.; Mizunuma, R.: Matsuoka, K.; Ogawa, H.; Kato, H.; Takasu, K.<br \/><I>ACS Med. Chem. Lett.<\/i>\u00a0<b>2024<\/b>, <em>15<\/em>, 287-293. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsmedchemlett.3c00526\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acsmedchemlett.3c00526<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/01\/P2024_1_Miwa.jpg\" alt=\"\" width=\"75%\" height=\"75%\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Synthesis of mesoionic triazolones via a formal [3+2] cycloaddition between 4-phenyl-1,2,4-triazoline-3,5-dione and alkynes<\/b><br \/>Kuroda, Y.; Krell, M.; Kurokawa, K.; Takasu, K. <br \/><I>Chem. Commun.<\/i>\u00a0<b>2024<\/b>, <em>60<\/em>, 1719-1722. <br \/><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2024\/cc\/d3cc05088b\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/D3CC05088B<\/a><img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/01\/P2024_1_Kuroda.jpg\" alt=\"\" width=\"75%\" height=\"75%\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2023<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Sequential Bromination\/Dearomatization Reactions of 2-Methoxyphenols en route to Bromo-Substituted ortho-Quinonemonoacetals<\/b><br \/>Hayashi, S.; Takasu, K.; Takikawa, H.<br \/><I>Synlett<\/i>\u00a0<b>2023<\/b>, <em>35<\/em>, 474-478. <br \/><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0041-1738450\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/s-0041-1738450<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2023\/08\/P2023_3_Hayashi.jpg\" alt=\"\" width=\"75%\" height=\"75%\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Rotaxane Synthesis by an End-Capping Strategy via Swelling Axle-Phenols<\/b><br \/>Fujimura, K.; Ueda, Y.; Yamaoka, Y.; Takasu, K.; Kawabata, T. <br \/><i>Angew. Chem. Int. Ed. <\/i>\u00a0<b>2023<\/b>, <em>63<\/em>, e202303078. <br \/><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202303078\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.202303078<\/a><\/li>\n<li><b>An Iridium\/Aluminum Cooperative Strategy for the \u03b2-C(sp3)\u2013H Borylation of Saturated Cyclic Amines<\/b><br \/>Kuroda, Y.; Park, K.; Shimazaki, Y.; Zhong, R.-L.; Sakaki, S.; Nakao, Y.<br \/><i>Angew. Chem. Int. Ed. <\/i>\u00a0<b>2023<\/b>, <em>62<\/em>, e202300704. <br \/><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202300704\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.202300704<\/a><\/li>\n<li><b>Efficient Synthesis of Medium-sized Nitrogen Heterocycles by Br\u00f8nsted Acid-Catalyzed Cyclization of Ene-ynamides<\/b><br \/>Yamaoka, Y.; Takeuchi, N.; Yamada, K.; Takasu, K.<br \/><I>Asian J. Org. Chem.<\/i>\u00a0<b>2023<\/b>, <em>12<\/em>, e202300145. <br \/><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajoc.202300145\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/ajoc.202300145<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2024\/04\/P2023_4_Yamaoka.jpg\" alt=\"\" width=\"70%\" height=\"70%\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Intramolecular Ynamide\u2013Benzyne (3+2) Cycloadditions<\/b><br \/>Tawatari, T.; Kato, R.; Kudo, R.; Takasu, K.; Takikawa, H.<br \/><I>Angew. Chem. Int. Ed.<\/i>\u00a0<b>2023<\/b>, <em>62<\/em>, e202300907. <br \/><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.202300907\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.202300907<\/a><br \/><a href=\"https:\/\/www.kyoto-u.ac.jp\/ja\/research-news\/2023-03-23-1\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">\u4eac\u90fd\u5927\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2023\/03\/P2023_2_Tawatari.jpg\" alt=\"\" width=\"80%\" height=\"80%\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Synthesis of \u03b3-Aryl Medium-sized Cyclic Enones by a domino 4\u03c0-Electrocyclic Reaction\u2014Heck\u2013Matsuda Arylation Sequence at Ambient Temperature<\/b><br \/>Ito, T.; Takeuchi, N.; Yamaoka, Y.; Takikawa, H.; Takasu, K.<br \/><I>Synthesis<\/i>\u00a0<b>2023<\/b>, <em>34<\/em>, 1275-1279. <br \/><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/a-2024-4675\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/a-2024-4675<\/a> <br \/><span class=\"red\">selected as the cover picture<\/span><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2023\/02\/P2023_1_Ito.jpg\" alt=\"\" width=\"70%\" height=\"70%\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2022<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Lewis Acid-Catalyzed Diastereoselective Domino Reaction of Ene-Ynamide with Trimethylsilyl Cyanide to Construct Spiroindolines<\/b><br \/>Yamaoka, Y.; Yamasaki, D.; Kajiwara, D.; Shinosaki, M.; Yamada, K.; Takasu, K.<br \/><i>Org. Lett.<\/i>\u00a0<b>2022<\/b>, <em>24<\/em>, 4389-4393. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.2c01607\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.2c01607<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2022\/06\/ol2c01607_0007-1.jpg\" alt=\"\" width=\"500\" height=\"166\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Enhanced Molecular Recognition through Substrate\u2013Additive Complex Formation in N-Heterocyclic-Carbene-Catalyzed Kinetic Resolution of \u03b1-Hydroxythioamides<\/b><br \/>Wang, Y.; Yamauchi, A.; Hashimoto, K.; Fujiwara, T.; Inokuma, T.; Mitani, Y.; Ute, K.; Kuwano, S.; Yamaoka, Y.; Takasu, K.; Yamada, K.<br \/><i>ACS Catal.<\/i>\u00a0<b>2022<\/b>, <em>12<\/em>, 6100-6107. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acscatal.2c01579\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acscatal.2c01579<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2022\/06\/P2022_5_Wang.jpg\" alt=\"\" width=\"709\" height=\"216\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Intramolecular Propargylic Ene Reaction of Benzyne en Route to Highly Functionalized Allenes and Allenamides<\/b><br \/>Tawatari, T.; Kato, R.; Takasu, K.; Takikawa, H.<br \/><i>Synthesis <\/i>\u00a0<b>2022<\/b>, <em>54<\/em>, 4979-4988. <br \/><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/a-1826-2545\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/a-1826-2545<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2022\/04\/P2022_1_Tawatari.jpg\" alt=\"\" width=\"550\" height=\"174\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>AI-Driven Synthetic Route Design Incorporated with Retrosynthesis Knowledge<\/b><br \/>Ishida, S.; Terayama, K.; Kojima, R.; Takasu, K.; Okuno, Y.<br \/><i>J. Chem. Inf. Model. <\/i>\u00a0<b>2022<\/b>, <em>62<\/em>, 1357-1367. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.1c01074\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.jcim.1c01074<\/a> <\/li>\n<li><b>Total Synthesis of Cryptopleurine and Its Analogues<\/b><br \/>Yamaoka, Y.; Yamakawa, T.; Tateishi, K.; Takasu, K.<br \/><i>Synthesis <\/i>\u00a0<b>2022<\/b>, <em>54<\/em>, 2415-2422. <br \/><a href=\"https:\/\/www.thieme-connect.de\/products\/ejournals\/abstract\/10.1055\/a-1730-8628\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/a-1730-8628<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2022\/04\/i_f0721_ga_10-1055_a-1730-8628.gif\" alt=\"\" width=\"600\" height=\"166\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Catalytic Substrate-Selective Silylation of Primary Alcohols via Remote Functional-Group Discrimination<\/b><br \/>Hashimoto, H.; Ueda, Y.; Takasu, K.; Kawabata, T.<br \/><i>Angew. Chem. Int. Ed. <\/i>\u00a0<b>2022<\/b>, <em>61<\/em>, e202114118. <br \/><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/anie.202114118\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.202114118<\/a> <\/li>\n<\/ul>\n<\/div>\n<h4>2021<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>2-(Chlorodiisopropylsilyl)-6-(trimethylsilyl)phenyl triflate: a modified platform for intramolecular benzyne cycloadditions<\/b><br \/>Tawatari, T.; Takasu, K.; Takikawa, H.<br \/><i>Chem. Commun. <\/i>\u00a0<b>2021<\/b>, <em>57<\/em>, 11863-11866. <br \/><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2021\/CC\/D1CC05264K\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/D1CC05264K<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2021\/10\/P2021_5_Tawatari.jpg\" alt=\"\" width=\"429\" height=\"198\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Oxidative \u03b2-Cleavage of Fused Cyclobutanols Leading to Hydrofuran-Fused Polycyclic Aromatic Compounds<\/b><br \/>Kinouchi, H.; Sugimoto, K.; Yamaoka, Y.; Takikawa, H.; Takasu, K.<br \/><i>J. Org. Chem. <\/i>\u00a0<b>2021<\/b>, <em>86<\/em>, 12615-12622. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.1c01108\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.joc.1c01108<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2021\/10\/P2021_4_Kinouchi.jpg\" alt=\"\" width=\"506\" height=\"108\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>The Rationale for Stereoinduction in Conjugate Addition to Alkylidenemalonates Bearing a Menthol-derived Chiral Auxiliary<\/b><br \/>Yamada, K.; Fujiwara, S.; Inokuma, T.; Sugano, M.; Yamaoka, Y.; Takasu, K.<br \/><i>Tetrahedron<\/i>\u00a0<b>2021<\/b>, <em>91<\/em>, 132220. <br \/><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0040402021004269\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tet.2021.132220<\/a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2021\/07\/Tetra2021.png\" alt=\"\" width=\"607\" height=\"134\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Mechanistic Support for Intramolecular Migrative Cyclization of Propargyl Sulfones Provided by Catalytic Asymmetric Induction with a Chiral Counter Cation Strategy<\/b><br \/>Yamasaki, K.; Yamauchi, A.; Inokuma, T.; Miyakawa, Y.; Wang, Y.; Oriez, R.; Yamaoka, Y.; Takasu, K.; Tanaka, M.; Kashiwada, Y.; Yamada, K.<br \/><i>Asian J. Org. Chem.<\/i>\u00a0<b>2021<\/b>, <em>10<\/em>, 1828-1834. <br \/><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajoc.202100274?af=R\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/ajoc.202100274<\/a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2021\/07\/AJOC2011_TOC.png\" alt=\"\" width=\"433\" height=\"86\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<li><b>Synthesis of Lactone-fused Cyclopropanes by Ring Contractive <span style=\"font-family: symbol\">a<\/span>-Ketol Rearrangement of Ketal-fused Cyclobutanones<\/b><br \/>Takasu, K.; Shigenaga, K.; Shimoda, K.; Takikawa, H.; Yamaoka, Y.<br \/><i>Heterocycles<\/i>\u00a0<b>2021<\/b>, <em>103<\/em>, 177-182. <br \/><a href=\"https:\/\/doi.org\/10.3987\/COM-20-S(K)6\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.3987\/COM-20-S(K)6<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/04\/TOC-1.jpg\" alt=\"\" width=\"282\" height=\"117\" class=\"aligncenter size-full wp-image-858\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2020<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Synthetic Study on Acremoxanthone A, Part 2: Model Study on EFG Xanthone Moiety via Nitrile Oxide Cycloaddition\u2013S<sub>N<\/sub>Ar Sequence<\/b><br \/>Nakakohara, H.; Hirano, Y.; Ohmori, K.; Takikawa, H.; Suzuki, K.<br \/><i>Synlett<\/i>\u00a0<b>2020<\/b>, <I>32<\/I>, 423-428. <br \/><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/a-1303-5613\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/a-1303-5613<\/a><\/li>\n<li><b>Total Synthesis of (\u2212)-Sigillin A: A Polychlorinated and Polyoxygenated Natural Product<\/b><br \/>Yamaoka, Y.; Nakayama, T.; Kawai, S.; Takasu, K.<br \/><i>Org. Lett.<\/i>\u00a0<b>2020<\/b>, <i>22<\/i>, 7721-7724. <br \/><a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.orglett.0c02930\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.0c02930<\/a><img decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/09\/P2020-6-Yamaoka.jpg\" alt=\"\" width=\"550\" class=\"wp-image-877  aligncenter\" \/><\/li>\n<li><b>CompRet: a comprehensive recommendation framework for chemical synthesis planning with algorithmic enumeration<\/b><br \/>Shibukawa, R.; Ishida, S.; Yoshizoe, K.; Wasa, K.; Takasu, K.; Okuno, Y.; Terayama, K.; Tsuda, K.<br \/><i>J. Cheminf.<\/i>\u00a0<b>2020<\/b>, <i>12<\/i>, 52. <br \/><a href=\"https:\/\/jcheminf.biomedcentral.com\/track\/pdf\/10.1186\/s13321-020-00452-5\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1186\/s13321-020-00452-5<\/a><\/li>\n<li><b>Synthetic Study on Lactonamycins, Part 2: Stereoselective Access to ABCD-Ring System<\/b><br \/>Takikawa, H.; Murata, K.; Sato, S.; Kawada, T.; Nakakohara, H.; Ohmori, K.; Suzuki, K.<br \/><i>Synlett<\/i> <b>2020<\/b>, <i>31<\/i>, 1623-1628. <br \/><a href=\"https:\/\/www.thieme-connect.de\/products\/ejournals\/abstract\/10.1055\/s-0040-1707198\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/s-0040-1707198<\/a><\/li>\n<li><b>Helical Nanographenes Embedded with Contiguous Azulene Units<\/b><br \/>Ogawa, N.; Yamaoka, Y.; Takikawa, H.; Yamada, K.; Takasu, K.<br \/><i>J. Am. Chem. Soc.<\/i>\u00a0<b>2020<\/b>, <em>142<\/em>, 13322-13327. <br \/><a href=\"https:\/\/doi.org\/10.1021\/jacs.0c06156\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/jacs.0c06156<\/a><br \/><a href=\"https:\/\/www.kyoto-u.ac.jp\/ja\/research-news\/2020-07-20-0\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">\u4eac\u90fd\u5927\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><br \/><a href=\"https:\/\/www.chem-station.com\/blog\/2020\/11\/AZULENE.html\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">Chem-Station\u30b9\u30dd\u30c3\u30c8\u30e9\u30a4\u30c8\u30ea\u30b5\u30fc\u30c1<\/a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/GA_200606-scaled-e1595094473336-1024x611.jpg\" alt=\"\" width=\"361\" height=\"215\" class=\"wp-image-877  aligncenter\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/GA_200606-scaled-e1595094473336-1024x611.jpg 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/GA_200606-scaled-e1595094473336-300x179.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/GA_200606-scaled-e1595094473336-768x459.jpg 768w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/GA_200606-scaled-e1595094473336-1536x917.jpg 1536w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/GA_200606-scaled-e1595094473336.jpg 1971w\" sizes=\"auto, (max-width: 361px) 100vw, 361px\" \/><\/li>\n<li><b>Intramolecular Benzyne\u2013Phenolate [4+2] Cycloadditions<\/b><br \/>Takikawa, H.; Nishii, A.; Takiguchi, H.; Yagishita, H.; Tanaka, M.; Hirano, K.; Uchiyama, M.; Ohmori, K.; Suzuki, K.\u00a0<br \/><i>Angew. Chem. Int. Ed.<\/i>\u00a0<b>2020<\/b>, <em>59<\/em>, 12440-12444. <br \/><a href=\"https:\/\/doi.org\/10.1002\/anie.202003131\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.202003131<\/a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/06\/P2020-1-takikawa.jpg\" alt=\"\" width=\"458\" height=\"190\" class=\"aligncenter wp-image-858\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2019<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Prediction and Interpretable Visualization of Retrosynthetic Reactions using Graph Convolutional Networks<\/b><br \/>Ishida, S.; Terayama, K.; Kojima, R.; Takasu, K.; Okuno, Y. <br \/><i>J. Chem. Inf. Model.<\/i> <b>2019<\/b>, <i>59<\/i>, 5026-5033. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.jcim.9b00538\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.jcim.9b00538<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/12\/P2019Ishida.jpg\" alt=\"\" width=\"450\" height=\"242\" class=\"aligncenter size-full wp-image-786\" \/><\/li>\n<li><b>Synthesis of Polycyclic Spirocarbocyles via Acid-Promoted Ring-Contraction\/Dearomative Ring-Closure Cascade of Oxapropellanes<\/b><br \/>Ogawa, N.; Yamaoka, Y.; Takikawa, H.; Takasu, K. <br \/><i>Org. Lett.<\/i> <b>2019<\/b>, <i>21<\/i>, 7563-7567. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b02835\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.9b02835<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P1.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-532\" width=\"547\" height=\"165\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P1.jpg 547w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P1-300x90.jpg 300w\" sizes=\"auto, (max-width: 547px) 100vw, 547px\" \/><\/li>\n<li><b>Synthesis of Dibenzoxazonines by Domino (2+2) Cycloaddition\u20144\u03c0 Electrocyclic Ring Opening Reaction of Cyclic Imines with Ynamides<\/b><br \/>Takasu, K.; Tsustumi, M.; Ito, T.; Takikawa, H.; Yamaoka, Y. <br \/><i>Heterocycles<\/i>, <b>2020<\/b>, <i>101<\/i>, 423-428. <br \/><a href=\"https:\/\/doi.org\/10.3987\/COM-19-S(F)39\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.3987\/COM-19-S(F)39<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P2.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-533\" width=\"590\" height=\"142\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P2.jpg 590w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P2-300x72.jpg 300w\" sizes=\"auto, (max-width: 590px) 100vw, 590px\" \/><\/li>\n<li><b>Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides and Echinocidins<\/b><br \/>Shimoda, K.; Yamaoka, Y.; Yoo, D.; Yamada, K.; Takikawa, H.; Takasu, K. <br \/><i>J. Org. Chem.<\/i> <b>2019<\/b>, <i>84<\/i>, 11014-11024. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.joc.9b01589\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.joc.9b01589<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P3.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-534\" width=\"512\" height=\"124\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P3.jpg 512w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P3-300x73.jpg 300w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/li>\n<li><b>Synthesis of Functionalized Medium-Sized trans-Cycloalkenes by 4\u03c0 Electrocyclic Ring Opening\u2013 Alkylation Cascade<\/b><br \/>Ito, T.; Tsutsumi, M.; Yamada, K.; Takikawa, H.; Yamaoka, Y.; Takasu, K.<br \/><i>Angew. Chem. Int. Ed.<\/i> <b>2019<\/b>, <i>58<\/i>, 11836-11840. <br \/><a href=\"https:\/\/doi.org\/10.1002\/anie.201906665\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.201906665<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P4.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-535\" width=\"620\" height=\"130\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P4.jpg 620w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P4-300x63.jpg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><\/li>\n<li><b>Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision<\/b><br \/>Mogi, Y.; Inanaga, K.; Tokuyama, H.; Ihara, M.; Yamaoka, Y.; Yamada, K.; Takasu, K. <br \/><i>Org. Lett.<\/i> <b>2019<\/b>, <i>21<\/i>, 3954\u20133958. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b01089\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.9b01089<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P5.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-536\" width=\"518\" height=\"221\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P5.jpg 518w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P5-300x128.jpg 300w\" sizes=\"auto, (max-width: 518px) 100vw, 518px\" \/><\/li>\n<li><b>Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine<\/b><br \/>Kono, M.; Harada, S.; Nozaki, T.; Hashimoto, Y.; Murata, S.; Gr\u00f6ger, H.; Kuroda, Y.; Yamada, K.; Takasu, K.; Hamada, Y.; Nemoto, T. <br \/><i>Org. Lett.<\/i> <b>2019<\/b>, <i>21<\/i>, 3750\u20133754. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b01198\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.9b01198<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P6.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-537\" width=\"424\" height=\"166\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P6.jpg 424w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P6-300x117.jpg 300w\" sizes=\"auto, (max-width: 424px) 100vw, 424px\" \/><\/li>\n<li><b>2-Bromo-6-(chlorodiisopropylsilyl)phenyl tosylate as an efficient platform for intramolecular benzyne\u2013diene [4+2] cycloaddition<\/b><br \/>Nishii, A.; Takikawa, H.; Suzuki, K. <br \/><i>Chem. Sci.<\/i> <b>2019<\/b>, <i>10<\/i>, 3840-3845. <br \/><a href=\"https:\/\/doi.org\/10.1039\/c8sc05518a\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/c8sc05518a<\/a>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/P2019_CS_takikawa.jpg\" alt=\"\" width=\"475\" height=\"222\" class=\" wp-image-900 aligncenter\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/P2019_CS_takikawa.jpg 866w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/P2019_CS_takikawa-300x140.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2020\/07\/P2019_CS_takikawa-768x359.jpg 768w\" sizes=\"auto, (max-width: 475px) 100vw, 475px\" \/><\/p>\n<\/li>\n<li><b>Optical Resolution via Catalytic Generation of Chiral Auxiliary<\/b><br \/>Kiyama, H.; Inokuma, T.; Kuroda, Y.; Yamaoka, Y.; Takasu, K.; Yamada, K. <br \/><i>Tetrahedron Lett.<\/i> <b>2019<\/b>, <i>60<\/i>, 175-177. <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2018.12.006\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tetlet.2018.12.006<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P7.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-538\" width=\"567\" height=\"134\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P7.jpg 567w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P7-300x71.jpg 300w\" sizes=\"auto, (max-width: 567px) 100vw, 567px\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2018<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Silyl enol etherification by a Tf<sub>2<\/sub>NH\/amine co-catalytic system for minimizing hazardous waste generation<\/b><br \/>Kurahashi, K.; Yamaoka, Y.; Takemoto, Y.; Takasu, K.<br \/><i>React. Chem. Eng.<\/i> <b>2018<\/b>, <i>3<\/i>, 626-630. <br \/><a href=\"https:\/\/doi.org\/10.1039\/C8RE00039E\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/C8RE00039E<\/a> <img loading=\"lazy\" decoding=\"async\" width=\"287\" height=\"140\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P8.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-539\" \/><\/li>\n<li><b>Synthesis and Properties of Tribenzocarbazoles via an Acid-Promoted Retro (2+2)-Cycloaddition of Azapropellanes<\/b><br \/>Ogawa, N.; Yamaoka, Y.; Takikawa, H.; Tsubaki, K.; Takasu, K.<br \/><i>J. Org. Chem.<\/i> <b>2018<\/b>, <i>83<\/i>, 7994-8002. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.joc.8b00870\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.joc.8b00870<\/a><br \/><span class=\"red\">Highlighted in Synfacts<\/span> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P9.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-540\" width=\"368\" height=\"179\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P9.jpg 368w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P9-300x146.jpg 300w\" sizes=\"auto, (max-width: 368px) 100vw, 368px\" \/><\/li>\n<li><b>Total Synthesis of Phenanthroquinolizidine Alkaloid Cryptopleurine and Phenanthroindolizidine Alkaloid Tylophorine<\/b><br \/>Yamaoka, Y.; Taniguchi, M.; Yamada, K.; Takasu, K. <br \/><i>Heterocycles<\/i> <b>2018<\/b>, <i>97<\/i>, 292-305. <br \/><a href=\"https:\/\/doi.org\/10.3987\/COM-18-S(T)19\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.3987\/COM-18-S(T)19<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P10.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-541\" width=\"617\" height=\"153\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P10.jpg 617w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P10-300x74.jpg 300w\" sizes=\"auto, (max-width: 617px) 100vw, 617px\" \/><\/li>\n<li><b>Total Synthesis of Bis-anthraquinone Antibiotic BE-43472B<\/b><br \/>Yamashita, Y.; Hirano, Y.; Takada, A.; Takikawa, H.; Suzuki, K. <br \/><i>Synthesis<\/i> <b>2018<\/b>, <i>50<\/i>, 2490-2515. <br \/><a href=\"https:\/\/doi.org\/10.1055\/s-0037-1610136\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/s-0037-1610136<\/a><\/li>\n<\/ul>\n<\/div>\n<h4>2017<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Synthesis of Multi-substituted Cyclobutenes: Cyclic Strategy for (2+2) Cycloaddition of Ketene Silyl Acetals with Propiolates<\/b><br \/>Yamaoka, Y.; Ueda, M.; Yamashita, T.; Shimoda, K.; Yamada, K.; Takasu, K. <br \/><i>Tetrahedron Lett.<\/i> <b>2017<\/b>, <i>58<\/i>, 2944-2947. <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2017.06.039\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tetlet.2017.06.039<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P11.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-542\" width=\"460\" height=\"120\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P11.jpg 460w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P11-300x78.jpg 300w\" sizes=\"auto, (max-width: 460px) 100vw, 460px\" \/><\/li>\n<li><b>Synthesis of \u03c0-Extended Fluoranthenes via a KHMDS-Promoted Anion and Radical Reaction Cascade<\/b><br \/>Ogawa, N.; Yamaoka, Y.; Yamada, K.; Takasu, K. <br \/><i>Org. Lett.<\/i> <b>2017<\/b>, <i>19<\/i>, 3327-3330. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.7b01538\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.orglett.7b01538<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P12.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-543\" width=\"564\" height=\"155\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P12.jpg 564w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P12-300x82.jpg 300w\" sizes=\"auto, (max-width: 564px) 100vw, 564px\" \/><\/li>\n<li><b>Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists<\/b><br \/>Arichi, N.; Fujiwara, S.; Ishizawa, M.; Makishima, M.; Hua, D. H.; Yamada, K.; Yamaoka, Y.; Takasu, K.<br \/><i>Bioorg. Med. Chem. Lett.<\/i> <b>2017<\/b>, <i>27<\/i>, 3408-3411. <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bmcl.2017.05.089\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.bmcl.2017.05.089<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P13.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-544\" width=\"462\" height=\"126\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P13.jpg 462w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P13-300x82.jpg 300w\" sizes=\"auto, (max-width: 462px) 100vw, 462px\" \/><\/li>\n<li><b>Site-selective benzoin-type cyclization of unsymmetrical dialdoses catalyzed by N-heterocyclic carbenes for divergent cyclitol synthesis<\/b><br \/>Kang, B.; Wang, Y.; Kuwano, S.; Yamaoka, Y.; Takasu, K.; Yamada, K. <br \/><i>Chem. Commun.<\/i> <b>2017<\/b>, <i>53<\/i>, 4469-4472. <br \/><a href=\"https:\/\/doi.org\/10.1039\/C7CC01191A\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI:10.1039\/C7CC01191A<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P14.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-545\" width=\"325\" height=\"169\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P14.jpg 325w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P14-300x156.jpg 300w\" sizes=\"auto, (max-width: 325px) 100vw, 325px\" \/><\/li>\n<li><b>Total Synthesis of (-)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction<\/b><br \/>Sato, M.; Azuma, H.; Daigaku, A.; Sato, S.; Takasu, K.; Okano, K.; Tokuyama, H.<br \/><i>Angew. Chem. Int. Ed.<\/i> <b>2017<\/b>, <i>56<\/i>, 1087-1091. <br \/><a href=\"https:\/\/doi.org\/10.1002\/anie.201609941\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.201609941<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P15.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-546\" width=\"882\" height=\"160\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P15.jpg 882w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P15-300x54.jpg 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P15-768x139.jpg 768w\" sizes=\"auto, (max-width: 882px) 100vw, 882px\" \/><\/li>\n<li><b>Phosphine-Promoted Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide for the Synthesis of Oxa- and Azacycles<\/b><br \/>Wang, Y.; Oriez, R.; Oh, S.; Miyakawa, Y.; Yamaoka, Y.; Takasu, K.; Yamada, K. <br \/><i>Heterocycels,<\/i> <b>2017<\/b>, <i>95<\/i>, 314-321. <br \/><a href=\"https:\/\/doi.org\/10.3987\/COM-16-S(S)22\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.3987\/COM-16-S(S)22<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P16.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-547\" width=\"310\" height=\"157\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P16.jpg 310w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P16-300x152.jpg 300w\" sizes=\"auto, (max-width: 310px) 100vw, 310px\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2016<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp<sup>3<\/sup>-Hybridized Carbon Atoms: Kinetic Resolution of \u03b2-Amino Alcohols by p-Methoxybenzylation<\/b><br \/>Kuroda, Y.; Harada, S.; Oonishi, A.; Kiyama, H.; Yamaoka, Y.; Yamada, K.; Takasu, K.<br \/><i>Angew. Chem. Int. Ed.<\/i> <b>2016<\/b>, <i>55<\/i>, 13137-13141. <br \/><a href=\"https:\/\/doi.org\/10.1002\/anie.201607208\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.201607208<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P17.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-548\" width=\"518\" height=\"148\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P17.jpg 518w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P17-300x86.jpg 300w\" sizes=\"auto, (max-width: 518px) 100vw, 518px\" \/><\/li>\n<li><b>Desymmetrization of acid anhydride with asymmetric esterification catalyzed by chiral phosphoric acid<\/b><br \/>Yamada, K.; Oonishi, A.; Kuroda, Y.; Harada, S.; Yamaoka, Y.; Kiyama, H.; Takasu, K. <br \/><i>Tetrahedron Lett.<\/i> <b>2016<\/b>, <i>57<\/i>, 4098-4100. <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2016.07.093\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tetlet.2016.07.093<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P18.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-549\" width=\"427\" height=\"211\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P18.jpg 427w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P18-300x148.jpg 300w\" sizes=\"auto, (max-width: 427px) 100vw, 427px\" \/><\/li>\n<li><b>Striking Difference between Succinimidomethyl and Phthalimidomethyl Radicals in Conjugate Addition to Alkylidenemalonate Initiated by Dimethylzinc<\/b><br \/>Yamada, K.; Matsumoto, Y.; Fujii, S.; Konishi, T.; Yamaoka, Y.; Takasu, K. <br \/><i>J. Org. Chem.<\/i> <b>2016<\/b>, <i>81<\/i>, 3809-3817. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.joc.6b00485\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.joc.6b00485<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P19.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-550\" width=\"375\" height=\"216\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P19.jpg 375w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P19-300x173.jpg 300w\" sizes=\"auto, (max-width: 375px) 100vw, 375px\" \/><\/li>\n<li><b>Oxa- and Azacycle Formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide with N-Heterocyclic Carbene<\/b><br \/>Wang, Y.; Oriez, R.; Kuwano, S.; Yamaoka, Y.; Takasu, K.; Yamada, K. <br \/><i>J. Org. Chem.<\/i> <b>2016<\/b>, <i>81<\/i>, 2652-2664. <br \/><a href=\"https:\/\/doi.org\/10.1021\/acs.joc.6b00182\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/acs.joc.6b00182<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P20.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-551\" width=\"392\" height=\"128\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P20.jpg 392w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P20-300x98.jpg 300w\" sizes=\"auto, (max-width: 392px) 100vw, 392px\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2015<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>An Arylative Ring Expansion Cascade of Fused Cyclobutenes via Short-Lived Intermediates with Planar Chirality<\/b><br \/>Arichi, N.; Yamada, K.; Yamaoka, Y.; Takasu, K. <br \/><i>J. Am. Chem. Soc.<\/i> <b>2015<\/b>, <i>137<\/i>, 9579-9682. <br \/><a href=\"https:\/\/doi.org\/10.1021\/jacs.5b06576\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/jacs.5b06576<\/a> <img loading=\"lazy\" decoding=\"async\" width=\"282\" height=\"145\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P22.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-552\" \/><\/li>\n<li><b>Asymmetric Total Synthesis of Tylophorine via a Formal [2+2] Cycloaddition Followed by Migrative Ring Opening of a Cyclobutane<\/b><br \/>Yamaoka, Y.; Taniguchi, M.; Yamada, K.; Takasu, K. <br \/><i>Synthesis<\/i> <b>2015<\/b>, <i>47<\/i>, 2819-2825. <br \/><a href=\"https:\/\/doi.org\/10.1055\/s-0034-1380430\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/s-0034-1380430<\/a> <br \/><span class=\"red\">The 10 most popular articles of the last month.<\/span> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P23.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-553\" width=\"565\" height=\"173\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P23.jpg 565w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P23-300x92.jpg 300w\" sizes=\"auto, (max-width: 565px) 100vw, 565px\" \/><\/li>\n<li><b>Organocatalytic Activation of the Leaving Group in the Intramolecular Asymmetric SN2&#8242; Reaction<\/b><br \/>Kuroda, Y.; Harada, S.; Oonishi, A.; Yamaoka, Y.; Yamada, K.; Takasu, K.<br \/><i>Angew. Chem. Int. Ed.<\/i> <b>2015<\/b>, <i>54<\/i>, 8263-8266. <br \/><a href=\"https:\/\/doi.org\/10.1002\/anie.201502831\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.201502831<\/a><br \/><span class=\"red\">Featured by Synfacts, selected as Synfact of the month, Featured by Advances in Engineering.<\/span> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P24.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-554\" width=\"558\" height=\"134\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P24.jpg 558w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P24-300x72.jpg 300w\" sizes=\"auto, (max-width: 558px) 100vw, 558px\" \/><\/li>\n<li><b>The Development of a Br\u00f8nsted Acid-promoted Ene-Ynamide Cyclization toward the Total Syntheses of Marinoquinolines A and C, and Aplidiopsamine<\/b><br \/>A, Yamaoka, Y.; Yoshida, T.; Shinozaki, M.; Yamada, K.; Takasu, K. <br \/><i>J. Org. Chem.<\/i> <b>2015<\/b>, <i>80<\/i>, 957-964. <br \/><a href=\"https:\/\/doi.org\/10.1021\/jo502467m\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/jo502467m<\/a><br \/><span class=\"red\">Featured by Synfacts<\/span> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P25.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-555\" width=\"669\" height=\"103\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P25.jpg 669w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P25-300x46.jpg 300w\" sizes=\"auto, (max-width: 669px) 100vw, 669px\" \/><\/li>\n<li><b>Synthesis of Steroidal Derivatives Bearing a Small Ring Using a Catalytic [2+2] Cycloaddition and a Ring-Contraction Rearrangement<\/b><br \/>Arichi, N.; Hata, K.; Takemoto, Y.; Yamada, K.; Yamaoka, Y.; Takasu, K. <br \/><i>Tetrahedron<\/i> <b>2015<\/b>, <i>71<\/i>, 233-243.\u3000 <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tet.2014.11.065\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tet.2014.11.065<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P26.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-556\" width=\"579\" height=\"211\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P26.jpg 579w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P26-300x109.jpg 300w\" sizes=\"auto, (max-width: 579px) 100vw, 579px\" \/><\/li>\n<li><b>Contiguous Radical Pivaloyloxymethylation-Directed C(sp<sup>3<\/sup>)-H Iodination of N-Tosyl Cycloalkanecarbaldimine<\/b><br \/>Fujii, S.; Nakano, M.; Yamaoka, Y.; Takasu, K.; Yamada, K.; Tomioka, K. <br \/><i>Tetrahedron Lett.<\/i> <b>2015<\/b>, <i>56<\/i>, 3086-3089. <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2014.11.105\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tetlet.2014.11.105<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P27.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-557\" width=\"290\" height=\"124\" \/><\/li>\n<li><b>Hydrostannylation-Cross-Coupling Strategy for Stereoselective Synthesis of Alkylidenemalonates and Related \u03b1,\u03b2-Unsaturated Esters<\/b><br \/>Fujiwara, S.; Cadou, R.; Yamaoka, Y.; Takasu, K.; Yamada, K. <br \/><i>Eur. J. Org. Chem.<\/i> <b>2015<\/b>, 1264-1272. <br \/><a href=\"https:\/\/doi.org\/10.1002\/ejoc.201403429\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/ejoc.201403429<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P28.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-558\" width=\"300\" height=\"181\" \/><\/li>\n<li><b>Synthetic Studies toward Penitrem E: Enantiocontrolled Construction of B-E Rings<\/b><br \/>Yoshii, Y.; Otsu, T.; Hosokawa, T.; Takasu, K.; Okano, K.; Tokuyama, K. <br \/><i>Chem. Commun.<\/i> <b>2015<\/b>, <i>51<\/i>, 1070-1073. <br \/><a href=\"https:\/\/doi.org\/10.1039\/C4CC08505A\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI:10.1039\/C4CC08505A<\/a><br \/><span class=\"red\">Featured by Synfacts<\/span> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P29.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-559\" width=\"514\" height=\"158\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P29.jpg 514w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P29-300x92.jpg 300w\" sizes=\"auto, (max-width: 514px) 100vw, 514px\" \/><\/li>\n<li><b>N-Heterocyclic Carbene-Catalyzed Benzoin Strategy for Divergent Synthesis of Cyclitol Derivatives from Alditols<\/b><br \/>Kang, B.; Suto, T.; Wang, Y.; Kuwano, S.; Yamaoka, Y.; Takasu, K.; Yamada, K. <br \/><i>Adv. Synth. Catal.<\/i> <b>2015<\/b>, <i>357<\/i>, 131-147. <br \/><a href=\"https:\/\/doi.org\/10.1002\/adsc.201400712\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/adsc.201400712<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P30.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-560\" width=\"519\" height=\"224\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P30.jpg 519w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P30-300x129.jpg 300w\" sizes=\"auto, (max-width: 519px) 100vw, 519px\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2014<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Stereocontrolled Total Synthesis And Biological Evaluation of (-)- And (+)-Petrosin and Its Derivatives<\/b><br \/>Toya, H.; Satoh, T.; Okano, K.; Takasu, K.; Ihara, M.; Takahashi, A.; Tanaka, H.; Tokuyama, H. <br \/><i>Tetrahedron<\/i> <b>2014<\/b>, <i>70<\/i>, 8129-8141. <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tet.2014.08.009\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tet.2014.08.009<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P31.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-561\" width=\"500\" height=\"190\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P31.jpg 500w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P31-300x114.jpg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/li>\n<li><b>Radical Amidomethylation of Imines<\/b><br \/>Fujii, S.; Konishi, T.; Matsumoto, Y.; Yamaoka, Y.; Takasu, K.; Yamada, K. <br \/><i>J. Org. Chem.<\/i> <b>2014<\/b>, <i>79<\/i>, 8128-8133. <br \/><a href=\"https:\/\/doi.org\/10.1021\/jo501332j\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/jo501332j<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P32.jpeg\" alt=\"\" class=\"aligncenter size-full wp-image-562\" width=\"500\" height=\"274\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P32.jpeg 500w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P32-300x164.jpeg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/li>\n<li><b>Equilibration of the EtAlCl2-Catalyzed [2 + 2] Cycloaddition of Silyl Enol Ethers: Diastereoselectivity Switch in the Synthesis of Fused Cyclobutanes<\/b><br \/>Hata, K.; Arichi, N.; Yamaoka, Y.; Yamada, K.; Takemoto, Y.; Takasu, K. <br \/><i>Asian J. Org. Chem.<\/i> <b>2014<\/b>, <i>3<\/i>, 706-710. <br \/><a href=\"https:\/\/doi.org\/10.1002\/ajoc.201402042\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/ajoc.201402042<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P33.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-563\" width=\"564\" height=\"114\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P33.jpg 564w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P33-300x61.jpg 300w\" sizes=\"auto, (max-width: 564px) 100vw, 564px\" \/><\/li>\n<li><b>Synthesis of Functionalized Polycyclic Aromatic Compounds via a Formal [2+2]-cycloaddition<\/b><br \/>Nagamoto, Y.; Yamaoka, Y.; Fujimura, S.; Takemoto, Y.; Takasu, K. <br \/><i>Org. Lett.<\/i> <b>2014<\/b>, <i>16<\/i>, 1008-1011. <br \/><a href=\"https:\/\/doi.org\/10.1021\/ol403757e\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/ol403757e<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P34.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-564\" width=\"566\" height=\"113\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P34.jpg 566w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P34-300x60.jpg 300w\" sizes=\"auto, (max-width: 566px) 100vw, 566px\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2013<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Enhanced Rate and Selectivity by Carboxylate Salt as a Basic Co-catalyst in Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Acylation of Secondary Alcohols<\/b><br \/>Kuwano, S.; Harada, S.; Kang, B.; Raphael, O.; Yamaoka, Y.; Takasu, K.; Yamada, K. <br \/><i>J. Am. Chem. Soc.<\/i> <b>2013<\/b>, <i>135<\/i>, 11485-11488. <br \/><a href=\"https:\/\/doi.org\/10.1021\/ja4055838\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/ja4055838<\/a><br \/><span class=\"red\">Featured by Synfacts<\/span> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P35.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-565\" width=\"500\" height=\"197\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P35.jpg 500w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P35-300x118.jpg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/li>\n<li><b>Kinetic resolution of secondary alcohols catalyzed by chiral phosphoric acids<\/b><br \/>Harada, S.; Kuwano, S.; Yamaoka, Y.; Yamada, K.; Takasu, K. <br \/><i>Angew. Chem. Int. Ed.<\/i> <b>2013<\/b>, <i>52<\/i>, 10227-10230. <br \/><a href=\"https:\/\/doi.org\/10.1002\/anie.201304281\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/anie.201304281<\/a><br \/><span class=\"red\">Featured by Synfacts<\/span> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P36.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-566\" width=\"482\" height=\"169\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P36.jpg 482w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P36-300x105.jpg 300w\" sizes=\"auto, (max-width: 482px) 100vw, 482px\" \/><\/li>\n<li><b>Synthesis of 2,3,4,5-Tetra-substituted Pyrroles via a Base-Promoted Double Michael Reaction of Oxime-enoates with Nitroolefins<\/b><br \/>Kuroda, Y.; Imaizumi, K.; Yamada, K.; Yamaoka, Y.; Takasu, K. <br \/><i>Tetrahedron Lett.<\/i> <b>2013<\/b>, <i>54<\/i>, 4073-4075. <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2013.05.100\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tetlet.2013.05.100<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P37.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-567\" width=\"564\" height=\"94\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P37.jpg 564w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P37-300x50.jpg 300w\" sizes=\"auto, (max-width: 564px) 100vw, 564px\" \/><\/li>\n<li><b>Selective Synthesis of Poly-Substituted Dihydroquinolines and \u03b1,\u03b2-Unsaturated Amidines by A Catalytic Reaction of Ynamides with Ketimines<\/b><br \/>Kuroda, Y.; Shindoh, N.; Takemoto, Y.; Takasu, K. <br \/><i>Synthesis<\/i> <b>2013<\/b>, <i>45<\/i>, 2318-2326. <br \/><a href=\"https:\/\/doi.org\/10.1055\/s-0033-1339191\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/s-0033-1339191<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P38.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-568\" width=\"506\" height=\"192\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P38.jpg 506w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P38-300x114.jpg 300w\" sizes=\"auto, (max-width: 506px) 100vw, 506px\" \/><\/li>\n<li><b>Critical profiles of chiral diether-mediated asymmetric conjugate aminolithiation of enoate with lithium amide as a key to the total synthesis of (-)-kopsinine<\/b><br \/>Harada, S.; Sakai, T.; Takasu, K.; Yamada, K.; Tomioka, K. <br \/><i>Tetrahedron<\/i> <b>2013<\/b>, <i>69<\/i>, 3264-3273. <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tet.2013.02.035\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1016\/j.tet.2013.02.035<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P39.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-569\" width=\"500\" height=\"128\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P39.jpg 500w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P39-300x77.jpg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/li>\n<li><b>pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols<\/b><br \/>Nagamoto, Y.; Hattori, A.; Kakeya, H.; Takemoto, Y.; Takasu, K. <br \/><i>Chem. Commun.<\/i> <b>2013<\/b>, <i>49<\/i>, 2622-2624. <br \/><a href=\"https:\/\/doi.org\/10.1039\/c3cc39246e\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/c3cc39246e<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P40.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-570\" width=\"453\" height=\"117\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P40.jpg 453w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P40-300x77.jpg 300w\" sizes=\"auto, (max-width: 453px) 100vw, 453px\" \/><\/li>\n<li><b>Study of Ring-Opening Reaction of Spiro[5.2]octenes with Aqueous Hydro-halic Acid: Substituent Effect on the Regioselectivity<\/b><br \/>Nagamoto, Y.; Takemoto, Y.; Takasu, K. <br \/><i>Synlett<\/i> <b>2013<\/b>, <i>24<\/i>, 120-124. <br \/><a href=\"https:\/\/doi.org\/10.1055\/s-0032-1317745\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1055\/s-0032-1317745<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P41.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-571\" width=\"387\" height=\"108\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P41.jpg 387w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P41-300x84.jpg 300w\" sizes=\"auto, (max-width: 387px) 100vw, 387px\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2012<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Total Synthesis of (+)-trans-Dihydronarciclasine Utilizing Asymmetric Conjugate Addition<\/b><br \/>Yamada, K.; Mogi, Y.; Mohamed, M. A.; Takasu, K.; Tomioka, K. <br \/><i>Org. Lett.<\/i> <b>2012<\/b>, <i>14<\/i>, 5868-5871. <br \/><a href=\"https:\/\/doi.org\/10.1021\/ol302757y\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/ol302757y<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P42.jpeg\" alt=\"\" class=\"aligncenter size-full wp-image-572\" width=\"500\" height=\"175\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P42.jpeg 500w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P42-300x105.jpeg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/li>\n<li><b>Total Synthesis of (-)-Kopsinine by an Asymmetric One-Pot [N+2+3] Cyclization<\/b><br \/>Harada, S.; Sakai, T.; Takasu, K.; Yamada, K.; Tomioka, K. <br \/><i>Chem. Asian J.<\/i> <b>2012<\/b>, <i>7<\/i>, 2196-2198.<br \/><a href=\"https:\/\/doi.org\/10.1002\/asia.201200575\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/asia.201200575<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P43.jpeg\" alt=\"\" class=\"aligncenter size-full wp-image-573\" width=\"500\" height=\"113\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P43.jpeg 500w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P43-300x68.jpeg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/li>\n<li><b>General Entry to Asymmetric One-Pot [N + 2 + n] Cyclization for the Synthesis of Three- to Seven-Membered Azacycloalkanes<\/b><br \/>Harada, S.; Sakai, T.; Takasu, K.; Yamada, K.; Tomioka, K. <br \/><i>J. Org. Chem.<\/i> <b>2012<\/b>, <i>77<\/i>, 7212-7222. Featured by Synfacts<br \/><a href=\"https:\/\/doi.org\/10.1021\/jo301495a\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/jo301495a<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P44.jpeg\" alt=\"\" class=\"aligncenter size-full wp-image-574\" width=\"500\" height=\"185\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P44.jpeg 500w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P44-300x111.jpeg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/li>\n<li><b>Facile Isomerization of Silyl Enol Ethers Catalyzed by Triflic Imide and Its Application to One-pot Isomerization-(2 + 2) Cycloaddition<\/b><br \/>Inanaga, K.; Ogawa, Y.; Nagamoto, Y.; Daigaku, A.; Tokuyama, H.; Takemoto, Y.; Takasu, K. <br \/><i>Beilstein J. Org. Chem.<\/i> <b>2012<\/b>, <i>8<\/i>, 658-661.<br \/><a href=\"https:\/\/doi.org\/10.3762\/bjoc.8.73\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.3762\/bjoc.8.73<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P45.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-575\" width=\"407\" height=\"78\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P45.jpg 407w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P45-300x57.jpg 300w\" sizes=\"auto, (max-width: 407px) 100vw, 407px\" \/><\/li>\n<li><b>Room-temperature, acid-catalyzed [2+2] cycloadditions: Suppression of side reactions by using a flow microreactor system<\/b><br \/>Kurahashi, K.; Takemoto, Y.; Takasu, K. <br \/><i>ChemSusChem<\/i> <b>2012<\/b>, <i>5<\/i>, 270-273.<br \/><a href=\"https:\/\/doi.org\/10.1002\/cssc.201100373\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/cssc.201100373<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P46.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-577\" width=\"325\" height=\"215\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P46.jpg 325w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P46-300x198.jpg 300w\" sizes=\"auto, (max-width: 325px) 100vw, 325px\" \/><\/li>\n<\/ul>\n<\/div>\n<h4>2011<\/h4>\n<div id=\"list\">\n<ul>\n<li><b>Formal (3 + 3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition-Claisen Condensation Accompanied with Isomerization of Silyl Enol Ethers<\/b><br \/>Azuma, T.; Takemoto, Y.; Takasu, K. <br \/><i>Chem. Pharm. Bull.<\/i> <b>2011<\/b>, <i>59<\/i>, 1190-1193.<br \/><a href=\"https:\/\/doi.org\/10.1248\/cpb.59.1190\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1248\/cpb.59.1190<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P47.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-578\" width=\"368\" height=\"85\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P47.jpg 368w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P47-300x69.jpg 300w\" sizes=\"auto, (max-width: 368px) 100vw, 368px\" \/><\/li>\n<li><b>Catalyst-Controlled Torquoselectivity Switch in the 4\u03c0 Ring-Opening Reaction of 2-Amino-2-azetines Giving \u03b2-Substituted \u03b1,\u03b2-Unsaturated Amidines<\/b><br \/>Shindoh, N.; Kitaura, K.; Takemoto, Y.; Takasu, K. <br \/><i>J. Am. Chem. Soc.<\/i> <b>2011<\/b>, <i>133<\/i>, 8470-8473.<br \/><a href=\"https:\/\/doi.org\/10.1021\/ja202576e\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/ja202576e<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P48.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-579\" width=\"612\" height=\"124\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P48.jpg 612w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P48-300x61.jpg 300w\" sizes=\"auto, (max-width: 612px) 100vw, 612px\" \/><\/li>\n<li><b>Unprecedented Synthesis of N,N-Divinylamines by Tf<sub>2<\/sub>NH-Catalyzed Reaction of Ynamide with Ketimine<\/b><br \/>Shindoh, N.; Takemoto, Y.; Takasu, K. <br \/><i>Heterocycles<\/i> <b>2011<\/b>, <i>82<\/i>, 1133-1136.<br \/><a href=\"https:\/\/doi.org\/10.3987\/COM-10-S(E)87\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.3987\/COM-10-S(E)87<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P49.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-595\" width=\"373\" height=\"88\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P49.jpg 373w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/P49-300x71.jpg 300w\" sizes=\"auto, (max-width: 373px) 100vw, 373px\" \/><\/li>\n<li><b>Gold(I)-Catalyzed Polycyclizations of Polyenyne-Type Anilines Based on Hydroamination and Consecutive Hydroarylation Cascade<\/b><br \/>Hirano, K.; Inaba, Y.; Takasu, K.; Oishi, S.; Takemoto, Y.; Fujii, N.; Ohno, H. <br \/><i>J. Org. Chem.<\/i> <b>2011<\/b>, <i>76<\/i>, 9068-9080.<br \/><a href=\"https:\/\/doi.org\/10.1021\/jo2018119\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1021\/jo2018119<\/a><\/li>\n<\/ul>\n<\/div>\n<h3 id=\"2\">Reviews<\/h3>\n<div id=\"list\">\n<ul>\n<li><b>\u8131\u82b3\u9999\u5316\u3055\u308c\u305f\u591a\u74b0\u6027\u82b3\u9999\u65cf\u30dd\u30ea\u30b1\u30c1\u30c9\u5929\u7136\u7269\u306e\u5408\u6210\u6226\u7565<\/b><br \/>\u7027\u5ddd\u7d18\uff0c\u9234\u6728\u5553\u4ecb\uff0c<br \/><i>\u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c<\/i>\uff0c<b>2019<\/b>, <i>77(1)<\/i>, 13-25. <br \/><a href=\"https:\/\/doi.org\/10.5059\/yukigoseikyokaishi.77.13\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.5059\/yukigoseikyokaishi.77.13<\/a><\/li>\n<li><b>Aryne-Based Strategy in Total Synthesis of Naturally-Occurring Polycyclic Compounds<\/b><br \/>Takikawa, H.; Nishii, A.; Sakai, T.; Suzuki, K. <br \/><i>Chem. Soc. Rev.<\/i> <b>2018<\/b>, <i>47<\/i>, 8030-8056. <br \/><a href=\"https:\/\/doi.org\/10.1039\/c8cs00350e\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1039\/c8cs00350e<\/a><br \/><span class=\"red\">Top 5% of highly cited authors with RSC journals in 2019<\/span><\/li>\n<li><b>\u30dd\u30ea\u30b1\u30c1\u30c9\u7cfb\u591a\u74b0\u6027\u5316\u5408\u7269\u306e\u5168\u5408\u6210\u306b\u304a\u3051\u308b\u8a66\u884c\u932f\u8aa4<\/b><br \/>\u7027\u5ddd\u7d18\uff0c<br \/><i>\u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c<\/i>\uff0c<b>2018<\/b>, <i>76(5)<\/i>, 478-481. <br \/><a href=\"https:\/\/doi.org\/10.5059\/yukigoseikyokaishi.76.478\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.5059\/yukigoseikyokaishi.76.478<\/a><\/li>\n<li><b>\u30ad\u30e9\u30eb\u30ea\u30f3\u9178\u306b\u3088\u308b\u89e6\u5a92\u7684\u4e0d\u6589\u7f6e\u63db\u53cd\u5fdc\u304a\u3088\u3073\u30a2\u30b7\u30eb\u5316\u53cd\u5fdc\u3078\u306e\u5c55\u958b<\/b><br \/>\u9ed2\u7530\u60a0\u4ecb\uff0c\u539f\u7530\u614e\u543e\uff0c\u5c71\u7530\u5065\u4e00\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c<br \/><i>\u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c<\/i>\uff0c<b>2018<\/b>, <i>76(4)<\/i>, 325-335. <br \/><a href=\"https:\/\/doi.org\/10.5059\/yukigoseikyokaishi.76.325\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.5059\/yukigoseikyokaishi.76.325<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/R1.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-520\" width=\"407\" height=\"153\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/R1.jpg 407w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/R1-300x113.jpg 300w\" sizes=\"auto, (max-width: 407px) 100vw, 407px\" \/><\/li>\n<li><b>Synthesis of Azaheterocycles and Related Molecules by Tf<sub>2<\/sub>NH-Catalyzed Cycloadditions<\/b><br \/>Shindo, N.; Takasu, K.<br \/><i> Heterocycles<\/i> <b>2018<\/b>, <i>96<\/i>, 195-218. <br \/><a href=\"https:\/\/doi.org\/10.3987\/REV-17-875\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.3987\/REV-17-875<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r2.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-522\" width=\"744\" height=\"201\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r2.jpg 744w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r2-300x81.jpg 300w\" sizes=\"auto, (max-width: 744px) 100vw, 744px\" \/><\/li>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<li><b>\u5f62\u5f0f\u7684[2+2]\u74b0\u5316\u53cd\u5fdc\u3092\u7528\u3044\u305f\u591a\u74b0\u82b3\u9999\u65cf\u70ad\u5316\u6c34\u7d20\u306e\u5408\u6210\u3068\u305d\u306e\u5fdc\u7528 (Efficient Synthesis of Polyaromatic Hydrocarbon via a Formal [2\uff0b2] Cycloaddition)<\/b><br \/>\u5c71\u5ca1\u5eb8\u4ecb(Yousuke Yamaoka)<br \/><i>Yakugaku Zasshi<\/i>, <b>2016<\/b>, <i>136<\/i>, 1517-1523. <br \/><a href=\"https:\/\/doi.org\/10.1248\/yakushi.16-00202\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1248\/yakushi.16-00202<\/a><\/li>\n<li><b>\u03c0-Delocalized Lipophilic Quaternary Cations as new Candidates for Antimalarial, Antitrypanosomal and Antileishmanial Agents: Synthesis, Evaluation of Antiprotozoal Potency and Insight of their Action Mechanism<\/b><br \/>Takasu, K. <br \/><i>Chem. Pharm. Bull.<\/i> <b>2016<\/b>, <i>64(7)<\/i>, 656-667. <br \/><a href=\"https:\/\/doi.org\/10.1248\/cpb.c16-00234\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1248\/cpb.c16-00234<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r3.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-523\" width=\"378\" height=\"143\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r3.jpg 378w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r3-300x113.jpg 300w\" sizes=\"auto, (max-width: 378px) 100vw, 378px\" \/><\/li>\n<li><b>Synthesis of Multisubstituted Silyloxy-based Donor-Acceptor Cyclobutanes by an Acid-Catalyzed [2+2] Cycloaddition<\/b><br \/>Takasu, K. <br \/><i>Israel J. Chem.<\/i> <b>2016<\/b>, <i>56(6-7)<\/i>, 488-498. <br \/><a href=\"https:\/\/doi.org\/10.1002\/ijch.201500096\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/ijch.201500096<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r4.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-524\" width=\"435\" height=\"116\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r4.jpg 435w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/r4-300x80.jpg 300w\" sizes=\"auto, (max-width: 435px) 100vw, 435px\" \/><\/li>\n<li><b>\u30c8\u30ea\u30d5\u30ea\u30c3\u30af\u30a4\u30df\u30c9\u306e\u30aa\u30fc\u30c8\u30fb\u30bf\u30f3\u30c7\u30e0\u89e6\u5a92\u4f5c\u7528\u3092\u5229\u7528\u3059\u308b\u6709\u6a5f\u5408\u6210<\/b><br \/>\u9ad8\u9808\u6e05\u8aa0\uff0c<br \/><i>\u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c<\/i>\uff0c<b>2014<\/b>, <i>72(7)<\/i>, 770-780. <br \/><a href=\"https:\/\/doi.org\/10.5059\/yukigoseikyokaishi.72.770\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.5059\/yukigoseikyokaishi.72.770<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/R5.jpg\" alt=\"\" class=\"aligncenter size-full wp-image-525\" width=\"370\" height=\"99\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/R5.jpg 370w, https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/R5-300x80.jpg 300w\" sizes=\"auto, (max-width: 370px) 100vw, 370px\" \/><\/li>\n<li><b>\u8ef8\u6027\u4e0d\u6589\u3092\u3082\u3064\u30a2\u30df\u30b8\u30f3\u306e\u89e6\u5a92\u7684\u4e0d\u6589\u5408\u6210\u6cd5\u306e\u958b\u767a\u3068\u30ad\u30e9\u30eb\u5408\u6210\u7d20\u5b50\u3068\u3057\u3066\u306e\u6d3b\u7528<\/b><br \/>\u9ad8\u9808\u6e05\u8aa0, <br \/><i>\u85ac\u5b66\u7814\u7a76\u306e\u9032\u6b69<\/i>, <b>2011<\/b>, 31-36.<\/li>\n<\/ul>\n<\/div>\n<h3 id=\"3\">Books<\/h3>\n<div id=\"list\">\n<ul>\n<li><b>\u30d5\u30ed\u30fc\u30de\u30a4\u30af\u30ed\u5408\u6210\u306e\u6700\u65b0\u52d5\u5411<\/b><br \/>\u9ad8\u9808\u6e05\u8aa0\u8457\u3001\u30d5\u30a1\u30a4\u30f3\u30b1\u30df\u30ab\u30eb\u5408\u6210\u30d7\u30ed\u30bb\u30b9<br \/><i>\u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248<\/i>, <b>2021<\/b>, pp.102-110. ISBN 978-4-7813-1615-4<\/li>\n<li><b>\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u85ac\u5b66\u30b7\u30ea\u30fc\u30baII-8\u3000\u85ac\u5b66\u7814\u7a76, \u65e5\u672c\u85ac\u5b66\u4f1a\u7de8<\/b><br \/>\u85e4\u591a\u54f2\u6717\u3001\u9ad8\u9808\u6e05\u8aa0\u8457\u3001\u4eba\u3068\u306e\u3064\u306a\u304c\u308a\u304c\u7d50\u5b9f\u3057\u3066\u8a95\u751f\u3057\u305f\u65b0\u85ac\uff0d\u51ac\u866b\u590f\u8349\u3092\u8d77\u6e90\u3068\u3059\u308b\u591a\u767a\u6027\u786c\u5316\u75c7\u6cbb\u7642\u85ac\u30d5\u30a3\u30f3\u30b4\u30ea\u30e2\u30c9<br \/><i>\u6771\u4eac\u5316\u5b66\u540c\u4eba<\/i>, <b>2017<\/b>, pp.36-44. ISBN 9784807917228<\/li>\n<li><b>\u304f\u3059\u308a\u3092\u3064\u304f\u308b\u7814\u7a76\u8005\u306e\u4ed5\u4e8b \u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u79d1\u7de8<\/b><br \/>\u9ad8\u9808\u6e05\u8aa0\u3001\u7b2c\uff12\u7ae0\u3000\u85ac\u3092\u5408\u6210\u3059\u308b\uff0d\u70ad\u7d20\u306e\u932c\u91d1\u8853\u5e2b<br \/><i>\u5316\u5b66\u540c\u4eba<\/i>\u3001<b>2017<\/b>, pp.35-62.\u3000ISBN 9784759819311.<\/li>\n<li><b>\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u85ac\u5b66\u30b7\u30ea\u30fc\u30baII -3\u3000\u5316\u5b66\u7cfb\u85ac\u5b66\u3000II.<\/b><br \/>\u4f0a\u85e4\u55ac\u3001\u77f3\u5d0e\u5e78\u3001\u77f3\u585a\u5fe0\u7537\u3001\u6a58\u9ad8\u6566\u3001\u9ad8\u9808\u6e05\u8aa0 \u7de8<br \/><i>\u6771\u4eac\u5316\u5b66\u540c\u4eba<\/i>, <b>2016<\/b>.<\/li>\n<li><b>\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u85ac\u5b66\u30b7\u30ea\u30fc\u30baII -3\u3000\u5316\u5b66\u7cfb\u85ac\u5b66\u3000III.<\/b><br \/>\u4f0a\u85e4\u55ac\u3001\u77f3\u5d0e\u5e78\u3001\u77f3\u585a\u5fe0\u7537\u3001\u6a58\u9ad8\u6566\u3001\u9ad8\u9808\u6e05\u8aa0\u3001\u4f9b\u7530\u6d0b\u3001\u68ee\u7530\u535a\u53f2 \u7de8\u3001<br \/><i>\u6771\u4eac\u5316\u5b66\u540c\u4eba<\/i>, <b>2016<\/b>.<\/li>\n<li><b>\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u85ac\u5b66\u30b7\u30ea\u30fc\u30baII- 3\u3000\u5316\u5b66\u7cfb\u85ac\u5b66\u3000I. \u5316\u5b66\u7269\u8cea\u306e\u6027\u8cea\u3068\u53cd\u5fdc<\/b><br \/>\u4f0a\u85e4\u55ac\u3001\u77f3\u5d0e\u5e78\u3001\u77f3\u585a\u5fe0\u7537\u3001\u6a58\u9ad8\u6566\u3001\u9ad8\u9808\u6e05\u8aa0 \u7de8\u3001\u7b2c\uff11\u7ae0 \u5316\u5b66\u7d50\u5408\u3068\u5206\u5b50\u3001<br \/><i>\u6771\u4eac\u5316\u5b66\u540c\u4eba<\/i>, <b>2015<\/b>, pp.2-14.<\/li>\n<li><b>\u30a6\u30a9\u30fc\u30ec\u30f3\u6709\u6a5f\u5408\u6210\uff0d\u9006\u5408\u6210\u304b\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\uff0d\uff08\u7ffb\u8a33\uff09<\/b><br \/>Warren, S. and Wyatt, P. \u8457\u3001\u67f4\u5d0e\u6b63\u52dd\u3001\u6a4b\u672c\u4fca\u4e00\u3000\u76e3\u8a33\u3001\u91d1\u4e95\u6c42\u3001\u6728\u8d8a\u82f1\u592b\u3001\u9ad8\u9808\u6e05\u8aa0\u3001\u677e\u6c38\u8302\u6a39\u3000\u8a33\u3001<br \/><i>\u6771\u4eac\u5316\u5b66\u540c\u4eba<\/i>\uff0c<b>2014<\/b>, pp. 202-279.\u3000<\/li>\n<li><b>Catalytic [2+2] Cycloaddition of Silyl Enol Ethers<\/b><br \/>Yamaoka, Y. and Takasu, K. <br \/><i>in Methods and Applications of Cycloaddition Reactions in Organic Syntheses, ed. by Nishiwaki, N. Wiley, New York,<\/i> <b>2014<\/b>, pp.115-134. <br \/><a href=\"https:\/\/doi.org\/10.1002\/9781118778173.ch04\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI:10.1002\/9781118778173.ch04<\/a><\/li>\n<li><b>Reactions involving an \u03b1,\u03b2-Unsaturated Carbonyl Compound as Electrophilic Component with [2+2] Cycloaddition as the Key Step<\/b><br \/>Takasu, K. <br \/><i>in Science of Synthesis (Multicomponent Reactions),<\/i> <b>2013<\/b>, Thieme, pp.195-210.<\/li>\n<li><b>Heterogeneous Reactions<\/b><br \/>Takasu, K. <br \/><i>in Microreactors in Organic Chemistry and Catalysis, 2nd edition, ed by Wirth, T. Wiley-VCH, Weinheim,<\/i> <b>2013<\/b>, pp. 151-196.<\/li>\n<li><b>\u539f\u866b\u30aa\u30eb\u30ac\u30cd\u30e9\u306e\u56fa\u6709\u74b0\u5883\u8a8d\u8b58\u3092\u57fa\u76e4\u3068\u3057\u305f\u6297\u30de\u30e9\u30ea\u30a2\u6d3b\u6027\u7269\u8cea\u306e\u5275\u88fd<\/b><br \/>\u9ad8\u9808\u6e05\u8aa0\uff0c<br \/><i>\u30ca\u30ce\u30d0\u30a4\u30aa\u6280\u8853\u3068\u5275\u85ac\u7814\u7a76\uff08\u4f50\u6cbb\u82f1\u90ce\u3089\u7de8\uff09\uff0c\u30e1\u30c7\u30a3\u30ab\u30eb\u30c9\u30a5\uff0c<\/i><b>2012<\/b>\u3001pp.72-77.<\/li>\n<li><b>Thiourea, <em>N<\/em>-[3,5-Bis(trifluoromethyl)phenyl]-<em>N<\/em>\u2019-[(1R,2R)-2-(dimethylamino)cyclohexyl]-<\/b><br \/>Takasu, K.; Takemoto, Y. <br \/><i>Encyclopedia of Reagents for Organic Synthesis (Wiley), <\/i><b>2012<\/b>, 1-4. <br \/><a href=\"https:\/\/doi.org\/10.1002\/047084289X.rn01414\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"liinternal\">DOI: 10.1002\/047084289X.rn01414<\/a> <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/B11.jpeg\" alt=\"\" class=\"aligncenter size-full wp-image-530\" width=\"194\" height=\"116\" \/><\/li>\n<\/ul>\n<\/div>\n<h3 id=\"4\">Patents<\/h3>\n<div id=\"list\">\n<ul>\n<li>\u9ad8\u9808\u6e05\u8aa0\u3001\u5965\u91ce\u606d\u53f2\u3001\u702c\u6728\u6075\u91cc\u3001\u539f\u8cb4\u53f2\u3001\u85e4\u6751\u99ff\u3001\u5c71\u672c\u4f73\u5b8f\u3001\u91d1\u4e95\u5343\u91cc\u3001\u5409\u5ddd\u9054\u4e5f\u3001\u95a8\u6b63\u535a\u3001\u6cb3\u91ce\u664b\u54c9 \u300c\u30d4\u30da\u30e9\u30b8\u30f3\u8a98\u5c0e\u4f53\u304a\u3088\u3073\u305d\u306e\u7528\u9014\u300d WO 2014\/024993\uff08\u7279\u9858JP2012-177572\uff09<\/li>\n<li>\u9ad8\u9808\u6e05\u8aa0\uff0c\u7af9\u672c\u4f73\u53f8\uff0c\u5009\u6a4b\u6167 \u300c\u30b7\u30ea\u30eb\u30a8\u30ce\u30fc\u30eb\u985e\u306e\u88fd\u9020\u6cd5\u300d \u7279\u98582010-48290<\/li>\n<li>\u9ad8\u9808\u6e05\u8aa0\uff0c\u4e95\u539f\u6b63\u9686\uff0c\u7a32\u6c38\u98a8\u4eba \u300c\u591a\u7f6e\u63db\u30b7\u30af\u30ed\u30d6\u30bf\u30f3\u53ca\u3073\u591a\u7f6e\u63db\u30b7\u30af\u30ed\u30d6\u30c6\u30f3\u5316\u5408\u7269\u306e\u88fd\u9020\u65b9\u6cd5\u300d \u7279\u958b2007-119488<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0cPudhom Khanitha\uff0c\u5317\u53e3\u535a\u53f8\uff0c\u5ddd\u4e0a\u96c5\u4e4b\uff0c\u4f50\u85e4\u5e78\u85cf \u300c\u30a2\u30b6\u30ed\u30c0\u30b7\u30a2\u30cb\u30f3\u5316\u5408\u7269\u3092\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u542b\u6709\u3059\u308b\u539f\u866b\u611f\u67d3\u75c7\u6cbb\u7642\u5264\u300d WO2006\/137258 (\u7279\u9858JP2005-50064)<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u5317\u53e3\u535a\u53f8\uff0c\u5ddd\u4e0a\u96c5\u4e4b\uff0c\u4f50\u85e4\u5e78\u85cf \u300c\u30d5\u30a7\u30ce\u30ad\u30b5\u30b8\u30cb\u30a6\u30e0\u5316\u5408\u7269\u3092\u6709\u52b9\u6210\u5206\u3068\u3059\u308b\u539f\u866b\u611f\u67d3\u75c7\u6cbb\u7642\u5264\u300d WO2006\/087935 (\u7279\u9858JP2005-41238)<\/li>\n<li>\u9ad8\u9808\u6e05\u8aa0\uff0c\u4e95\u539f\u6b63\u9686\uff0c\u7a32\u6c38\u98a8\u4eba \u300c\u591a\u7f6e\u63db\u30b7\u30af\u30ed\u30d6\u30bf\u30f3\u53ca\u3073\u591a\u7f6e\u63db\u30b7\u30af\u30ed\u30d6\u30c6\u30f3\u5316\u5408\u7269\u306e\u88fd\u9020\u65b9\u6cd5\u300d WO2006\/009119 (\u7279\u9858JP2006-529195)<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0cPudhom Khanitha\uff0c\u5317\u53e3\u535a\u53f8\uff0c\u5ddd\u4e0a\u96c5\u4e4b\uff0c\u4f50\u85e4\u5e78\u85cf \u300c\u539f\u866b\u5bc4\u751f\u611f\u67d3\u75c7\u306e\u4e88\u9632\u53c8\u306f\u6cbb\u7642\u7528\u533b\u85ac\u7d44\u6210\u7269\u300d \u7279\u958b2006-104116<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0cPudhom Khanitha\uff0c\u5317\u53e3\u535a\u53f8\uff0c\u5ddd\u4e0a\u96c5\u4e4b\uff0c\u4f50\u85e4\u5e78\u85cf \u300c\u6297\u30c8\u30ea\u30d1\u30ce\u30bd\u30fc\u30de\u5264\u300d \u7279\u958b2006-104115\uff0c\u672a\u8acb\u6c42<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0 \u300c\u30de\u30e9\u30ea\u30a2\u5897\u6b96\u963b\u5bb3\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u300d \u7279\u958b2006-67867<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u897f\u7530\u76f4\u5b50 \u300c\u7f6e\u63db\u30d4\u30da\u30ea\u30b8\u30f3\u53ca\u3073\u305d\u306e\u88fd\u6cd5\u300d \u7279\u958bJP2005-75785<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u5bfa\u5185\u5e83\u6bc5\uff0c\u95a2\u7530\u7bc0\u5b50\uff0c\u9ad8\u6a4b\u771f\u7406\u8863 \u300c\u30ea\u30fc\u30b7\u30e5\u30de\u30cb\u30a2\u6cbb\u7642\u5264\u300d \u7279\u958bJP2004-331545<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u5bfa\u5185\u5e83\u6bc5 \u300c\u30e1\u30ed\u30b7\u30a2\u30cb\u30f3\u7cfb\u8272\u7d20\u5316\u5408\u7269\u53ca\u3073\u30ed\u30c0\u30b7\u30a2\u30cb\u30f3\u7cfb\u8272\u7d20\u5316\u5408\u7269\u306e\u30b3\u30f3\u30d3\u30ca\u30c8\u30ea\u30a2\u30eb\u88fd\u9020\u65b9\u6cd5\u300d \u7279\u958bJP2004-137271<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u4f0a\u4e0a\u535a\u53f2\uff0c\u7dbf\u77e2\u6709\u4f51\uff0c\u91d1\u60e0\u6dd1 \u300c\u30de\u30e9\u30ea\u30a2\u611f\u67d3\u8a3a\u65ad\u5264\u304a\u3088\u3073\u30de\u30e9\u30ea\u30a2\u539f\u866b\u67d3\u8272\u5264\u300d \u7279\u958bJP2004-144526<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u7dbf\u77e2\u6709\u4f51\uff0c\u91d1\u60e0\u6dd1 \u300c\u30ed\u30c0\u30b7\u30a2\u30cb\u30f3\u7cfb\u8272\u7d20\u5316\u5408\u7269\u3092\u542b\u6709\u3059\u308b\u6297\u30de\u30e9\u30ea\u30a2\u5264\u300d \u7279\u958bJP2003-34642<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u7dbf\u77e2\u6709\u4f51\uff0c\u91d1\u60e0\u6dd1 \u300c\u56db\u74b0\u6027\u8907\u7d20\u5316\u5408\u7269\u3092\u542b\u6709\u3059\u308b\u6297\u30de\u30e9\u30ea\u30a2\u5264\u300d \u7279\u958bJP2003-34641<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u7dbf\u77e2\u6709\u4f51\uff0c\u91d1\u60e0\u6dd1 \u300c\u30ed\u30c0\u30b7\u30a2\u30cb\u30f3\u8272\u7d20\u5316\u5408\u7269\u3092\u542b\u6709\u3059\u308b\u6297\u30de\u30e9\u30ea\u30a2\u5264\u300d \u7279\u958bJP2003-34640<\/li>\n<li>\u4e95\u539f\u6b63\u9686\uff0c\u9ad8\u9808\u6e05\u8aa0\uff0c\u7dbf\u77e2\u6709\u4f51\uff0c\u91d1\u60e0\u6dd1 \u300c\u6297\u30de\u30e9\u30ea\u30a2\u6d3b\u6027\u3092\u6709\u3059\u308b\u65b0\u898f\u5316\u5408\u7269\u300d \u7279\u958bJP2001-24755<\/li>\n<\/ul>\n<\/div>\n<p><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Original Papers 2026 One-Pot Multi-Substrate Screening of Ligation Reactions Usi &#8230; <\/p>\n","protected":false},"author":29,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","footnotes":""},"class_list":["post-16","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/pages\/16","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/comments?post=16"}],"version-history":[{"count":6,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/pages\/16\/revisions"}],"predecessor-version":[{"id":1675,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/pages\/16\/revisions\/1675"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/media?parent=16"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}