![\"\"](\"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/files\/2019\/11\/takasu-234x300.jpg\")
<\/p>\n<\/p>\n
\u6559\u6388\u3000Professor
\u9ad8\u9808 \u6e05\u8aa0\u3000Kiyosei TAKASU<\/p>\n
E-mail\uff1akay-t [at] pharm.kyoto-u.ac.jp<\/p>\n
TEL\uff1a075-753-4553
FAX\uff1a075-753-4604<\/p>\n
Database\uff1a \u4eac\u5927\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9<\/a>\u30fbORCID<\/a>\u30fbResearchmap<\/a>\u30fbKAKEN<\/a><\/p>\n \u6709\u6a5f\u5408\u6210\u5316\u5b66\u3092\u57fa\u76e4\u306b\u3001\u7279\u7570\u306a\u6a5f\u80fd\u3084\u69cb\u9020\u3092\u6709\u3059\u308b\u5206\u5b50\u3092\u5275\u308a\u3060\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u72ec\u81ea\u306e\u5de5\u592b\u3092\u3053\u3089\u3057\u3066\u3001\u3072\u3068\u304c\u300c\u3042\u3063\u300d\u3068\u9a5a\u304f\u3088\u3046\u306a\u6a5f\u80fd\u3092\u6709\u3059\u308b\u5206\u5b50\u306e\u958b\u767a\u3084\u3001\u300c\u304a\uff5e\u300d\u3068\u611f\u5fc3\u3059\u308b\u3088\u3046\u306a\u5206\u5b50\u5909\u63db\u6cd5\u306e\u958b\u62d3\u3092\u76ee\u6307\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002 \u7814\u7a76\u306e\u30e2\u30c3\u30c8\u30fc\u306f\u3001\u300c\u304a\u3082\u308d\u3044\u7814\u7a76\u300d\u300c\u308f\u304f\u308f\u304f\u3059\u308b\u7814\u7a76\u300d\u300c\u81ea\u5206\u306b\u3057\u304b\u3067\u304d\u306a\u3044\u7814\u7a76\u300d\u3067\u3059\u3002 \u300c\u3055\u3059\u304c\u3001\u85ac\u54c1\u5408\u6210\u5316\u5b66\u5206\u91ce\u300d\u3068\u3044\u308f\u308c\u308b\u7814\u7a76\u5ba4\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n \u535a\u58eb\uff08\u85ac\u5b66\uff09\u3000Ph.D. in Pharmaceutical Sciences<\/p>\n \u3072\u305a\u307f\u5316\u5408\u7269\u306e\u5316\u5b66\u3000 Dr. Takasu has developed a variety of catalytic (2+2) cycloadditions of electron-donating olefins with electron-withdrawing olefin partners. The reactions enable to supply multi-functionalized\/substituted cyclobutanes and cyclobutenes. He also discovered new transformation reactions from the 4-membered rings into a variety of structures, such as spiro\/fused cyclopropanes, medium-sized rings, bridged molecules and polyaromatic hydrocarbons. He applied the results to the design of new intelligent molecules, which display unique biological actions.<\/p>\n \u65b0\u898f\u9023\u7d9a\u53cd\u5fdc\u3001\u591a\u6210\u5206\u53cd\u5fdc\u306e\u958b\u62d3\u3000 He discovered several classes of domino reactions using anionic, cationic, radical and pericyclic chemistry. He focuses on \u201ctandem catalysis\u201d in domino reactions, in which catalyst(s) promote more than two fundamentally different reactions in a single reactor. The methods enable to construct complex molecular structures from simple substances in a single operation. He has also explored the new utility of strong Bronsted acid, triflimide (Tf2NH).<\/p>\n \u5929\u7136\u7269\u306e\u5408\u6210\u7814\u7a76\u3000 He has achieved total synthesis of several natural terpenes, such as cedranes, culmorine, longiborneol, paesslerin A (reported and revised structures), and protoilludanes. He also accomplished synthesis of alkaloids, such as deplancheine, several simple beta-carboline alkaloids, lepadifrmines, and trans-Dihydronarciclasine. He also reported the synthesis of partial structure of several natural products. He uses his original reactions in the syntheses of the above natural products.<\/p>\n \u5206\u5b50\u4e0d\u6589\u306e\u5316\u5b66\u3000 He is interested in atropisomerism based on axial, planar and helical chirality. He also reported the enantioselective catalytic reactions using axially chiral organocatalysts<\/p>\n \u533b\u85ac\u54c1\u5316\u5b66\uff08\u71b1\u5e2f\u75c5\u6cbb\u7642\u85ac\u306e\u958b\u767a\uff09\u3000 He investigated the development of new candidate treatments for malaria, American trypanosomiasis, human African trypanosomiasis and leishmaniasis. He found that several synthetic compounds displayed excellent in vitro & in vivo efficacies against Plasmodium berghei when administered intraperitoneally or orally. He also explored the mechanism of action by chemical biology approach.<\/p>\n","protected":false},"excerpt":{"rendered":" \u9ad8\u9808\u6e05\u8aa0\u3000Kiyosei TAKASU \u6559\u6388\u3000Professor\u9ad8\u9808 \u6e05\u8aa0\u3000Kiyosei TAKASU E-mail\uff1akay-t [at] pharm.kyo … <\/p>\n","protected":false},"author":29,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","footnotes":""},"class_list":["post-373","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/pages\/373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/comments?post=373"}],"version-history":[{"count":6,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/pages\/373\/revisions"}],"predecessor-version":[{"id":1366,"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/pages\/373\/revisions\/1366"}],"wp:attachment":[{"href":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/wp-json\/wp\/v2\/media?parent=373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\u30e1\u30c3\u30bb\u30fc\u30b8\u3000Message<\/h3>\n
\u5b66\u4f4d\u3000Degree<\/h3>\n
\u7d4c\u6b74\u3000Education<\/h3>\n
\n\n
B.Sc., Faculty of Pharmaceutical Sciences, Kyoto University, Japan
(Directors: Prof. Kaoru FUJI; Institute of Chemical Research, Kyoto University)<\/li>\n
M.Sc., Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
(Directors: Prof. Kaoru FUJI; Institute of Chemical Research, Kyoto University)<\/li>\n
Ph.D., Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
(Directors: Prof. Kaoru FUJI; Institute of Chemical Research, Kyoto University)<\/li>\n<\/ul>\n<\/div>\n\u8077\u6b74\u3000Work Experience<\/h3>\n
\n\n
Visiting Scholar, Department of Chemistry, Kansas State University, USA (Prof. Duy H. Hua)<\/li>\n
JSPS Research Fellow, Japan Society for the Promotion of Science<\/li>\n
Assistant Professor, Faculty of Pharmaceutical Sciences, Tohoku University, Japan<\/li>\n
Assistant Professor, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan<\/li>\n
Lecturer, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan<\/li>\n
Associate Professor, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan<\/li>\n
Professor, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan<\/li>\n<\/ul>\n<\/div>\n\u6240\u5c5e\u5b66\u4f1a\u3000Membership<\/h3>\n
\n\n
\u53d7\u8cde\u3000Award<\/h3>\n
\n\n
Encouraging Award in Pharmaceutical Society of Japan, Tohoku District (The Pharmaceutical Society of Japan, Tohoku District)<\/li>\n
Fujisawa Award in Synthetic Organic Chemistry, Japan (Society of Synthetic Organic Chemistry, Japan<\/li>\n
3rd Young Scientist’s Research Award in Natural Product Chemistry, Japan<\/li>\n
Incentive Award in Synthetic Organic Chemistry, Japan<\/li>\n
Incentive Award in Intelligent Cosmos Foundation, Japan<\/li>\n
The Chemical Society of Japan Lecture Award for Young Chemists (CSJ, Japan)<\/li>\n\u7814\u7a76\u5185\u5bb9\u3000Research Summary<\/h3>\n
Chemistry of Strained Molecules<\/p>\n
Development of New Domino\/Multicomponent Reactions<\/p>\n
Synthetic Studies towards Natural Products<\/p>\n
Molecular Chirality and Dynamic Molecular Motion<\/p>\n\uff5e\u73fe\u5728\u5b9f\u65bd\u3057\u3066\u3044\u306a\u3044\u7814\u7a76 (not currently conducted)\uff5e<\/h5>\n
Medicinal Chemistry (Development of New Drug Candidates for Tropical Diseases)<\/p>\n