{"id":509,"date":"2019-11-20T20:27:38","date_gmt":"2019-11-20T11:27:38","guid":{"rendered":"https:\/\/testwebcil2.com\/takikawa\/?page_id=509"},"modified":"2019-11-20T20:27:38","modified_gmt":"2019-11-20T11:27:38","slug":"publicationsprevious-ver","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/gousei\/publicationsprevious-ver\/","title":{"rendered":"Publications(previous ver.)"},"content":{"rendered":"

Publications (previous ver.) <\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n <\/tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n 2019<\/b><\/font>\n <\/td>\n\n Synthesis of Polycyclic Spirocarbocyles via Acid-Promoted Ring-Contraction\/Dearomative Ring-Closure Cascade of Oxapropellanes<\/a><\/p>\n
Naoki Ogawa, Yousuke Yamaoka, Hiroshi Takikawa, Kiyosei Takasu
\n Org. Lett.<\/i> <\/b>, in press<\/i>.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis of Dibenzoxazonines by Domino (2+2) Cycloaddition-4\u03c0 Electrocyclic Ring Opening Reaction of Cyclic Imines with Ynamides<\/a><\/p>\n
Kiyosei Takasu, Masaki Tsutsumi, Tomohiro Ito, Hiroshi Takikawa, Yousuke Yamaoka
\n Hetereocycles<\/i> <\/b>, in press<\/i>.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides and Echinocidins<\/a><\/p>\n
Kazuma Shimoda, Yousuke Yamaoka, Dongeun Yoo, Ken-ichi Yamada, Hiroshi Takikawa, and Kiyosei Takasu
\n J. Org. Chem.<\/i> 2019<\/b>, 84<\/i>, 11014-11024.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis of Functionalized Medium-Sized trans-Cycloalkenes by 4\u03c0 Electrocyclic Ring Opening?Alkylation Cascade<\/a><\/p>\n
Tomohiro Ito, Masaki Tsutsumi, Ken-ichi Yamada, Hiroshi Takikawa, Yousuke Yamaoka, Kiyosei Takasu
\n Angew. Chem. Int. Ed.<\/i> 2019<\/b>, 58<\/i>, 11836-11840.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision<\/a><\/p>\n
Yuzo Mogi, Kazato Inanaga, Hidetoshi Tokuyama, Masataka Ihara, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu
\n Org. Lett.<\/i> 2019<\/b>, 21<\/i>, 3954-3958.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine<\/a><\/p>\n
Masato Kono, Shingo Harada, Tomoyuki Nozaki, Yoshinori Hashimoto, Shun-ichi Murata, Harald Groger, Yusuke Kuroda, Ken-ichi Yamada, Kiyosei Takasu, Yasumasa Hamada, and Tetsuhiro Nemoto
\n Org. Lett.<\/i> 2019<\/b>, 21<\/i>, 3750-3754.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Optical resolution via catalytic generation of chiral auxiliary<\/a><\/p>\n
Hiroki Kiyama, Tsubasa Inokuma, Yusuke Kuroda, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada
\n Tetrahedron Lett.<\/i> 2019<\/b>, 60<\/i>, 175-177.<\/dd>\n<\/td>\n<\/tr>\n
\n 2018<\/b><\/font>\n <\/td>\n\n Silyl Enol Etherification by Tf2<\/sub>NH\/Amine Co-catalytic System for Minimizing Hazardous Waste Generation.<\/a><\/p>\n
Kei Kurahashi, Yousuke Yamaoka, Yoshiji Takemoto, and Kiyosei Takasu
\n React. Chem. Eng.<\/i> 2018<\/b>, 3<\/i>, 626-630.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis and Properties of Tribenzocarbazoles via an Acid-promoted Retro (2+2)-Cycloaddition of Azapropellanes<\/a><\/p>\n
Naoki Ogawa, Yousuke Yamaoka, Hiroshi Takikawa, Kazunori Tsubaki, and Kiyosei Takasu
\n J. Org. Chem.<\/i> 2018<\/b>, 83<\/i>, 7994-8002.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Total Synthesis of Phenanthroquinolizidine Alkaloid Cryptopleurine and Phenanthroindolizidine Alkaloid Tylophorine.<\/a><\/p>\n
Yousuke Yamaoka, Marie Taniguchi, Ken-ichi Yamada, and Kiyosei Takasu
\n Heterocyles<\/i> 2018<\/b>, 97<\/i>, 292-305.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n \u30dd\u30ea\u30b1\u30c1\u30c9\u7cfb\u591a\u74b0\u6027\u5929\u7136\u7269\u306e\u5168\u5408\u6210\u306b\u304a\u3051\u308b\u8a66\u884c\u932f\u8aa4<\/a><\/p>\n
\u6edd\u5ddd\u7d18
\n \u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c<\/i> 2018<\/b>, 76<\/i>, 478-481.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis of Aza-Heterocycles and Related Molecules by Tf2<\/sub>NH-Catalyzed Cycloadditions.<\/a><\/p>\n
Naoya Shindo, and Kiyosei Takasu,
\n Heterocyles<\/i> 2018<\/b>, 96<\/i>, 195-218.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n \u30ad\u30e9\u30eb\u30ea\u30f3\u9178\u306b\u3088\u308b\u89e6\u5a92\u7684\u4e0d\u6589\u7f6e\u63db\u53cd\u5fdc\u304a\u3088\u3073\u30a2\u30b7\u30eb\u5316\u53cd\u5fdc\u3078\u306e\u5c55\u958b<\/a><\/p>\n
\u9ed2\u7530\u60a0\u4ecb\u3001\u539f\u7530\u614e\u543e\u3001\u5c71\u7530\u5065\u4e00\u3001\u9ad8\u9808\u6e05\u8aa0
\n \u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c<\/i> 2018<\/b>, 76<\/i>, 325-335.<\/dd>\n<\/td>\n<\/tr>\n
\n 2017<\/b><\/font>\n <\/td>\n\n Synthesis of Multi-substituted Cyclobutenes: Cyclic Strategy for [2 + 2] Cycloaddition of Ketene Silyl Acetals with Propiolates.<\/a><\/p>\n
Yousuke Yamaoka, Motoki Ueda, Tohru Yamashita, Kazuma Shimoda, Ken-ichi Yamada and Kiyosei Takasu,
\n Tetrahedron Lett.<\/i> 2017<\/b>, 58<\/i>, 2944-2947.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis of \u03c0-Extended Fluoranthenes via a KHMDS-promoted Anionic-Radical Reaction Cascade.<\/a><\/p>\n
Naoki Ogawa, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu,
\n Org. Lett.<\/i> 2017<\/b>, 19<\/i>, 3327-3330.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists.<\/a><\/p>\n
Norihito Arichi, Shinichi Fujiwara, Michiyasu Ishizawa, Makoto Makishima, Duy H. Hua, Ken-ichi Yamada, Yousuke Yamaoka and Kiyosei Takasu,
\n Bioorg. Med. Chem. Lett.<\/i> 2017<\/b>, in press.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Site-selective Benzoin-type Cyclization of Unsymmetrical Dialdoses Catalyzed by N-Heterocyclic Carbenes for Divergent Cyclitol Synthesis.<\/a><\/p>\n
Bubwoon Kang, Yinli Wang, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu and Ken-ichi Yamada,
\n Chem. Commun.<\/i> 2017<\/b>, 53, 4469-4472.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Phosphine-Promoted Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide for the Synthesis of Oxa- and Azacycles.<\/a><\/p>\n
Yinli Wang, Raphael Oriez, Shogun Oh, Yasunori Miyakawa, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada,
\n Heterocycles<\/i> 2017<\/b>, 95<\/i>, 314-321.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n \u4eba\u3068\u306e\u3064\u306a\u304c\u308a\u304c\u7d50\u5b9f\u3057\u3066\u8a95\u751f\u3057\u305f\u65b0\u85ac\u301c\u51ac\u866b\u590f\u8349\u3092\u8d77\u6e90\u3068\u3059\u308b\u591a\u767a\u6027\u786c\u5316\u75c7\u6cbb\u7642\u85ac\u30d5\u30a3\u30f3\u30b4\u30ea\u30e2\u30c9\u301c<\/a><\/p>\n
\u85e4\u591a\u54f2\u6717\u3001\u9ad8\u9808\u6e05\u8aa0
\n \u85ac\u5b66\u7814\u7a76\uff08\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u85ac\u5b66\u30b7\u30ea\u30fc\u30baII-8\uff09<\/i>; \u65e5\u672c\u85ac\u5b66\u4f1a\u7de8; \u6771\u4eac\u5316\u5b66\u540c\u4eba, 2017<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n \u85ac\u3092\u5408\u6210\u3059\u308b\u2014\u2014\u70ad\u7d20\u306e\u932c\u91d1\u8853\u5e2b<\/a><\/p>\n
\u9ad8\u9808\u6e05\u8aa0
\n \u304f\u3059\u308a\u3092\u3064\u304f\u308b\u7814\u7a76\u8005\u306e\u4ed5\u4e8b<\/i>; \u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u79d1\u7de8; \u5316\u5b66\u540c\u4eba, 2017; \u7b2c\uff12\u7ae0.<\/dd>\n<\/td>\n<\/tr>\n
\n 2016<\/b><\/font>\n <\/td>\n\n Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp3<\/sup>-Hybridized Carbon Atoms: Kinetic Resolution of beta-Amino Alcohols by p<\/i>-Methoxybenzylation.<\/a><\/p>\n
Yusuke Kuroda, Shingo, Harada, Akinori Oonishi, Hiroki Kiyama, Yousuke Yamaoka, Ken-ichi Yamada and Kiyosei Takasu,
\n Angew. Chem. Int. Ed.<\/i> 2016<\/b>, 55<\/i>, 13137–<\/font>13141.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Desymmetrization of Acid Anhydride with Asymmetric Esterification Catalyzed by Chiral Phosphoric Acid.<\/a><\/p>\n
Ken-ichi Yamada, Akinori Oonishi, Yusuke Kuroda, Shingo Harada, Hiroki Kiyama, Yousuke Yamaoka, and Kiyosei Takasu,
\n Tetrahedron Lett.<\/i> 2016<\/b>, 57<\/i> (36), 4098–<\/font>4100.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n \u03c0-Delocalized Lipophilic Quaternary Cations as new Candidates for Antimalarial, Antitrypanosomal and Antileishmanial Agents: Synthesis, Evaluation of Antiprotozoal Potency and Insight of their Action Mechanism (Review).<\/a><\/p>\n
Kiyosei Takasu,
\n Chem. Pharm. Bull.<\/i>, 2016<\/b>, 137<\/i> 64(7), 656–<\/font>667.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis of Multisubstituted Silyloxy-based Donor-Acceptor Cyclobutanes by an Acid-Catalyzed [2+2] Cycloaddition (Review).<\/a><\/p>\n
Kiyosei Takasu,
\n Israel J. Chem.<\/i>, 2016<\/b>, 137<\/i> 56(6-7), 488–<\/font>498.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Striking Difference between Succinimidomethyl and Phthalimidomethyl Radicals in Conjugate Addition to Alkylidenemalonate Initiated by Dimethylzinc.<\/a><\/p>\n
Ken-ichi Yamada, Yusuke Matsumoto, Shintaro Fujii, Takehito Konishi, Yousuke Yamaoka, and Kiyosei Takasu,
\n J. Org. Chem.<\/i> 2016<\/b>, 81<\/i> (9), 3809–<\/font>3817.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Oxa- and Azacycle-formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide with N-Heterocyclic Carbene.<\/a><\/p>\n
Yinli Wang, Raphaël Oriez, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada,
\n J. Org. Chem.<\/i> 2016<\/b>, 81<\/i> (6), 2652–<\/font>2664.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n \u5f62\u5f0f\u7684[2+2]\u74b0\u5316\u53cd\u5fdc\u3092\u7528\u3044\u305f\u591a\u74b0\u82b3\u9999\u65cf\u70ad\u5316\u6c34\u7d20\u306e\u5408\u6210\u3068\u305d\u306e\u5fdc\u7528\uff08H27\u65e5\u672c\u85ac\u5b66\u4f1a\u8fd1\u757f\u652f\u90e8\u5968\u52b1\u8cde\u53d7\u8cde\u8a18\u5ff5\u8ad6\u6587\uff09<\/a><\/p>\n
\u5c71\u5ca1\u5eb8\u4ecb
\n \u85ac\u5b66\u96d1\u8a8c<\/i> 2016<\/b>, 136<\/i> (11), 1517–<\/font>1523.<\/dd>\n<\/td>\n<\/tr>\n
\n 2015<\/b><\/font>\n <\/td>\n\n An Arylative Ring Expansion Cascade of Fused Cyclobutenes via Short-Lived Intermediates with Planar Chirality.<\/a><\/p>\n
Norihito Arichi, Ken-ichi Yamada, Yousuke Yamaoka, and Kiyosei Takasu,
\n J. Am. Chem. Soc.<\/i> 2015<\/b>, 137<\/i> (30), 9579–<\/font>9582.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Exploration of Dimethylzinc-Mediated Radical Reactions (Review).<\/a><\/p>\n
Ken-ichi Yamada and Kiyoshi Tomioka,
\n Chem. Rec.<\/i> 2015<\/b>, 15<\/i> (5), 854–<\/font>871.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Asymmetric Total Synthesis of Tylophorine via a Formal [2+2] Cycloaddition Followed by Migrative Ring Opening of a Cyclobutane.<\/a><\/p>\n
Yousuke Yamaoka, Marie Taniguchi, Ken-ichi Yamada, and Kiyosei Takasu,
\n Synthesis<\/i> 2015<\/b>, 47<\/i> (18), 2819–<\/font>2825.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Organocatalytic Activation of the Leaving Group in the Intramolecular Asymmetric SN<\/sub>2′ Reaction.<\/a><\/p>\n
Yusuke Kuroda, Shingo Harada, Akinori Oonishi, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu,
\n Angew. Chem. Int. Ed.<\/i> 2015<\/b>, 54<\/i> (28), 8263–<\/font>8266.
\n
\n Synfacts<\/i> 2015<\/b>, 11<\/i> (8), 871.<\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Cyclic Model for the Asymmetric Conjugate Addition of Organolithium with Enoate.<\/a><\/p>\n
Katsumi Nishimura, Naoshi Fukuyama, Mitsuaki Yamashita, Takaaki Sumiyoshi, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Synthesis<\/i> 2015<\/b>, 47<\/i> (15), 2256–<\/font>2264.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n A Short Synthesis of (+)-β-Lycorane by Asymmetric Conjugate Addition Cascade.<\/a><\/p>\n
Katsumi Nishimura, Naoshi Fukuyama, Tomohisa Yasuhara, Mitsuaki Yamashita, Takaaki Sumiyoshi, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2015<\/b>, 71<\/i> (39), 7222–<\/font>7226.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n The Development of a Brønsted Acid-promoted Arene-Ynamide Cyclization toward the Total Syntheses of Marinoquinolines A and C, and Aplidiopsamine A.<\/a><\/p>\n
Yousuke Yamaoka, Takahiro Yoshida, Makiko Shinozaki, Ken-ichi Yamada, and Kiyosei Takasu,
\n J. Org. Chem.<\/i> 2015<\/b>, 80<\/i> (2), 957–<\/font>964.
\n
\n Synfacts<\/i> 2015<\/b>, 11<\/i> (4), 358.<\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Hydrostannylation–<\/font>Cross-Coupling Strategy for Stereoselective Synthesis of Alkylidenemalonates and Related α,β-Unsaturated Esters.<\/a><\/p>\n
Shinichi Fujiwara, Romain Cadou, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada,
\n Eur. J. Org. Chem.<\/i> 2015<\/b>, (6), 1264–<\/font>1272.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis of Steroidal Derivatives Bearing a Small Ring Using a Catalytic [2+2] Cycloaddition and a Ring-Contraction Rearrangement.<\/a><\/p>\n
Norihito Arichi, Kenji Hata, Yoshiji Takemoto, Ken-ichi Yamada, Yousuke Yamaoka, and Kiyosei Takasu,
\n Tetrahedron<\/i> 2015<\/b>, 71<\/i> (2), 233–<\/font>244.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Contiguous Radical Pivaloyloxymethylation-Directed C(sp<\/i>3<\/sup>)–<\/font>H Iodination of N<\/i>-Tosyl Cycloalkanecarbaldimine.<\/a><\/p>\n
Shintaro Fujii, Mayu Nakano, Yousuke Yamaoka, Kiyosei Takasu, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Tetrahedron Lett.<\/i> 2015<\/b>, 56<\/i> (23), 3086–<\/font>3089.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n N-Heterocyclic Carbene-Catalyzed Benzoin Strategy for Divergent Synthesis of Cyclitol Derivatives from Alditols.<\/a><\/p>\n
Bubwoong Kang, Toshiaki Sutou, Yinli Wang, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada,
\n Adv. Synth. Catal.<\/i> 2015<\/b>, 357<\/i> (1), 131–<\/font>147.<\/dd>\n<\/td>\n<\/tr>\n
\n 2014 <\/b><\/font>\n <\/td>\n\n Radical Aminomethylation of Imines.<\/a><\/p>\n
Shintaro Fujii, Takehito Konishi, Yusuke Matsumoto, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada,
\n J. Org. Chem.<\/i> 2014<\/b>, 79<\/i> (17), 8128–<\/font>8133.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Equilibration of the [2+2] Cycloaddition of Silyl Enol Ethers Catalyzed by Ethylaluminium Dichloride: Diastereoselectivity Switch in the Synthesis of Fused Cyclobutanes.<\/a><\/p>\n
Kenji Hata, Norihito Arichi, Yousuke Yamaoka, Ken-ichi Yamada, Yoshiji Takemoto, and Kiyosei Takasu,
\n Asian J. Org. Chem.<\/i> 2014<\/b>, 3<\/i> (6), 706–<\/font>710.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis of Functionalized Polycyclic Aromatic Compounds via a Formal [2 + 2]-Cycloaddition.<\/a><\/p>\n
Yuuki Nagamoto, Yousuke Yamaoka, Shun Fujimura, Yoshiji Takemoto, and Kiyosei Takasu,
\n Org. Lett.<\/i> 2014<\/b>, 16<\/i> (3), 1008–<\/font>1011.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Copper-Catalyzed Asymmetric Addition Reaction of Imines.<\/a><\/p>\n
Kiyoshi Tomioka, Ken-ichi Yamada, and Yasutomo Yamamoto,
\n Copper-Catalyzed Asymmetric Synthesis<\/i>; Alexakis, A., Krause, N., Woodward, S., Eds; Wiley-VCH, 2014; Chapter 9.<\/dd>\n<\/td>\n<\/tr>\n
\n 2013 <\/b><\/font>\n <\/td>\n\n Enhanced Rate and Selectivity by Carboxylate Salt as a Basic Co-catalyst in Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Acylation of Secondary Alcohols.<\/a><\/p>\n
Satoru Kuwano, Shingo Harada, Bubwoong Kang, Raphaël Oriez, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada,
\n J. Am. Chem. Soc.<\/i> 2013<\/b>, 135<\/i> (31), 11485–<\/font>11488.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Chiral Phosphoric Acid-Catalyzed Kinetic Resolution of Secondary Alcohols.<\/a><\/p>\n
Shingo Harada, Satoru Kuwano, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu,
\n Angew. Chem. Int. Ed.<\/i> 2013<\/b>, 52<\/i> (39), 10227–<\/font>10230.
\n
\n Synfacts<\/i> 2013<\/b>, 9<\/i> (11), 1236.<\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Selective Synthesis of Poly-Substituted Dihydroquinolines and α,β-Unsaturated Amidines by A Catalytic Reaction of Ynamides with Ketimines.<\/a><\/p>\n
Yusuke Kuroda, Naoya Shindoh, Yoshiji Takemoto, and Kiyosei Takasu,
\n Synthesis<\/i> 2013<\/b>, 45<\/i> (16), 2328–<\/font>2326.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Synthesis of 2,3,4,5-Tetra-substituted Pyrroles via a Base-Promoted Double Michael Reaction of Oxime-enoates with Nitroolefins.<\/a><\/p>\n
Yusuke Kuroda, Kazuto Imaizumi, Ken-ichi Yamada, Yousuke Yamaoka, and Kiyosei Takasu,
\n Tetrahedron Lett.<\/i> 2013<\/b>, 54<\/i> (31), 4073–<\/font>4075.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Critical Profiles of Chiral Diether-Mediated Asymmetric Conjugate Aminolithiation of Enoate with Lithium Amide as a Key to the Total Synthesis of (–<\/font>)-Kopsinine.<\/a><\/p>\n
Shingo Harada, Takeo Sakai, Kiyosei Takasu, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2013<\/b>, 69<\/i> (15), 3264–<\/font>3273.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols.<\/a><\/p>\n
Yuuki Nagamoto, Akira Hattori, Hideaki Kakeya, Yoshiji Takemoto, and Kiyosei Takasu,
\n Chem. Commun.<\/i> 2013<\/b>, 49<\/i> (26), 2622–<\/font>2624.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Study of Ring-Opening Reaction of Spiro[5.2]octenes with Aqueous Hydro-halic Acid: Substituent Effect on the Regioselectivity.<\/a><\/p>\n
Yuuki Nagamoto, Yoshiji Takemoto, and Kiyosei Takasu,
\n Synlett<\/i> 2013<\/b>, 24<\/i> (1), 120–<\/font>124.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Catalytic [2+2] Cycloaddition of Silyl Enol Ethers.<\/a><\/p>\n
Yousuke Yamaoka and Kiyosei Takasu,
\n Methods and Applications of Cycloaddition Reactions in Organic Syntheses<\/i>; Nishiwaki, N. Ed; Wiley-VCH, 2013; Chapter 4.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Heterogeneous Reactions.<\/a><\/p>\n
Kiyosei Takasu,
\n Microreactors in Organic Chemistry and Catalysis<\/i>, 2nd edition; Wirth, T. Ed; Wiley-VCH, 2013; Chapter 7.<\/dd>\n<\/td>\n<\/tr>\n
\n 2012<\/b><\/font>\n <\/td>\n\n Total Synthesis of (+)-trans<\/i>-Dihydronarciclasine Utilizing Asymmetric Conjugate Addition.<\/a><\/p>\n
Ken-ichi Yamada, Yuzo Mogi, Magdi A. Mohamed, Kiyosei Takasu, and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2012<\/b>, 14<\/i> (23), 5868–<\/font>5871.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n General Entry to Asymmetric One-Pot [N<\/i> + 2 + n<\/i>] Cyclization for the Synthesis of Three- to Seven-Membered Azacycloalkanes.<\/a><\/p>\n
Shingo Harada, Takeo Sakai, Kiyosei Takasu, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n J. Org. Chem.<\/i> 2012<\/b>, 77<\/i> (17), 7212–<\/font>7222. Featured Article<\/i><\/font>.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Total Synthesis of (–<\/font>)-Kopsinine by an Asymmetric One-Pot [N+2+3] Cyclization.<\/a><\/p>\n
Shingo Harada, Takeo Sakai, Kiyosei Takasu, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n Chem. Asian. J.<\/i> 2012<\/b>, 7<\/i> (10), 2196–<\/font>2198.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Radical One-Pot α,β-Dual and β-Mono Oxymethylation of Alkylidenemalonate.<\/a><\/p>\n
Ken-ichi Yamada, Takehito Konishi, Mayu Nakano, Shintaro Fujii, Romain Cadou, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n J. Org. Chem.<\/i> 2012<\/b>, 77<\/i> (13), 5775–<\/font>5780.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Steric Tuning of Chiral C<\/i>2<\/sub>-Symmetric NHC in Gold-Catalyzed Asymmetric Cyclization of 1,6-Enynes.<\/a><\/p>\n
Ken-ichi Yamada, Yasumasa Matsumoto, Khalid B. Selim, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2012<\/b>, 68<\/i> (22), 4159–<\/font>4165.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n High Performance of N<\/i>-Alkoxycarbonyl-Imines in Triethylborane-Mediated Tin-Free Radical Addition.<\/a><\/p>\n
Ken-ichi Yamada, Takehito Konishi, Mayu Nakano, Shintaro Fujii, Romain Cadou, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n J. Org. Chem.<\/i> 2012<\/b>, 77<\/i> (3), 1547–<\/font>1553.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Chemoselective Conversion of α-Unbranched Aldehyde to Amide, Ester, and Carboxylic Acid by NHC-Catalysis.<\/a><\/p>\n
Satoru Kuwano, Shingo Harada, Raphaël Oriez, and Ken-ichi Yamada,
\n Chem. Commun.<\/i> 2012<\/b>, 48<\/i> (1), 145–<\/font>147.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Acid-Catalyzed [2 + 2] Cycloaddition at Room-Temperature with Suppression of Side Reactions by Using a Flow Microreactor System.<\/a><\/p>\n
Kei Kurahashi, Yoshiji Takemoto, and Kiyosei Takasu,
\n ChemSusChem<\/i> 2012<\/b>, 5<\/i> (2), 270–<\/font>273.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Stoichiometric Auxiliary Ligands for Metals and Main Group Elements: Ligands for Lithium.<\/a><\/p>\n
Kiyoshi Tomioka, Yasutomo Yamamoto, and Ken-ichi Yamada,
\n Comprehensive Chirality<\/i>; Carreira, E. M., Yamamoto, H., Eds; Elsevier, 2012; Vol. 3, Chapter 20.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n C–C Bond Formation (Transition Metal-Catalyzed Michael).<\/a><\/p>\n
Kiyoshi Tomioka, Yasutomo Yamamoto, and Ken-ichi Yamada,
\n Comprehensive Chirality<\/i>; Carreira, E. M., Yamamoto, H., Eds; Elsevier, 2012; Vol. 4, Chapter 7.<\/dd>\n<\/td>\n<\/tr>\n
\n 2011<\/b><\/font>\n <\/td>\n\n Formal (3 + 3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition–Claisen Condensation Accompanied with Isomerization of Silyl Enol Ethers.<\/a><\/p>\n
Takumi Azuma, Yoshiji Takemoto, and Kiyosei Takasu,
\n Chem. Pharm. Bull.<\/i> 2011<\/b>, 59<\/i> (9),1190–<\/font>1193.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Steric Influence of N<\/i>-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation.<\/a><\/p>\n
Xinyu Hao, Qian Chen, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2011<\/b>, 67<\/i> (35), 6469–<\/font>6473.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines.<\/a><\/p>\n
Naoya Shindoh, Kazuo Kitaura, Yoshiji Takemoto, and Kiyosei Takasu,
\n J. Am. Chem. Soc.<\/i> 2011<\/b>, 133<\/i> (22), 8470–<\/font>8473.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Chiral N-Heterocyclic Carbene–Copper(I)-Catalyzed Asymmetric Allylic Arylation of Aliphatic Allylic Bromides: Steric and Electronic Effects on γ-Selectivity.<\/a><\/p>\n
Khalid B. Selim, Hirotsugu Nakanishi, Yasumasa Matsumoto, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n J. Org. Chem.<\/i> 2011<\/b>, 76<\/i> (5), 1398–<\/font>1408.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Rhodium-Catalyzed Asymmetric Phenylation of N<\/i>-Phosphinoylarylimines with Triphenylborane.<\/a><\/p>\n
Xinyu Hao, Qian Chen, Masami Kuriyama, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n Catal. Sci. Tech.<\/i> 2011<\/b>, 1<\/i> (1), 62–<\/font>64.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Unprecedented Synthesis of N,N-Divinylamines by Tf2<\/sub>NH-Catalyzed Reaction of Ynamide with Ketimine.<\/a><\/p>\n
Naoya Shindoh, Yoshiji Takemoto, and Kiyosei Takasu,
\n Heterocycles.<\/i> 2011<\/b>, 82<\/i> (2), 1133–<\/font>1136.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n \u8ef8\u6027\u4e0d\u6589\u3092\u3082\u3064\u30a2\u30df\u30b8\u30f3\u306e\u89e6\u5a92\u7684\u4e0d\u6589\u5408\u6210\u6cd5\u306e\u958b\u767a\u3068\u30ad\u30e9\u30eb\u5408\u6210\u7d20\u5b50\u3068\u3057\u3066\u306e\u6d3b\u7528.<\/p>\n
\u9ad8\u9808\u6e05\u8aa0,
\n \u85ac\u5b66\u7814\u7a76\u306e\u9032\u6b69<\/i> 2011<\/b>, 31–<\/font>36.<\/dd>\n<\/td>\n<\/tr>\n
\n 2010<\/b><\/font>\n <\/td>\n\n Stereoselective Formal Synthesis of (+)-Allokainic Acid via Thiol-Mediated Acyl Radical Cyclization.<\/a><\/p>\n
Ken-ichi Yamada, Tomohiro Sato, Masaki Hosoi, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n Chem. Pharm. Bull.<\/i> 2010<\/b>, 58<\/i> (11), 1511–<\/font>1516.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N<\/i>-Sulfinyl Imines.<\/a><\/p>\n
Tito Akindele, Ken-ichi Yamada, Takumi Sejima, Masaru Maekawa, Yasutomo Yamamoto, Mayu Nakano, and Kiyoshi Tomioka,
\n Chem. Pharm. Bull.<\/i> 2010<\/b>, 58<\/i> (2), 265–<\/font>269.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Chiral Carbene Approach to Gold-Catalyzed Asymmetric Cyclization of 1,6-Enynes.<\/a><\/p>\n
Yasumasa Matsumoto, Khalid B. Selim, Hirotsugu Nakanishi, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n Tetrahedron Lett.<\/i> 2010<\/B>, 51<\/i> (2), 404–<\/font>406.<\/dd>\n<\/td>\n<\/tr>\n
\n 2009<\/b><\/font>\n <\/td>\n\n Efficient Chiral N-Heterocyclic Carbene\/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents<\/a> <\/p>\n
Khalid B. Selim, Yasumasa Matsumoto, Ken-ichi Yamada, and Kiyoshi Tomioka,\n <\/dd>\n
Angew. Chem. Int. Ed.<\/i> 2009<\/b>, 48<\/i> (46), 8733–<\/font>8735.
\n Hot Paper<\/font>
\n <\/i>
\n
\n Synfacts<\/i> 2010<\/b>, (1), 77.<\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N<\/i>-Phosphinoyl Aldimines.<\/a><\/p>\n
Xinyu Hao, Masami Kuriyama, Qian Chen, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2009<\/b>, 11<\/i> (19), 4470–<\/font>4473.
\n
\n Synfacts<\/i> 2010<\/b>, (1), 69.<\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Iron Chloride Enhancement of Dimethylzinc-Mediated Radical Conjugate Addition of Ethers and an Amine to Alkylidenemalonates<\/a> <\/p>\n
Ken-ichi Yamada, Masaru Maekawa, Yasutomo Yamamoto, Mayu Nakano, Tito Akindele, and Kiyoshi Tomioka,
\n Tetrahedron Lett.<\/i> 2009<\/b>, 50<\/i> (44), 6040–<\/font>6043.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids.<\/a><\/p>\n
Qian Chen, Masami Kuriyama, Xinyu Hao, Takahiro Soeta, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Chem. Pharm. Bull.<\/i> 2009<\/b>, 57<\/i> (9), 1024–<\/font>1027.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Asymmetric Construction of Binaphthyl by the Chiral Diether-Mediated Conjugate Addition of Naphthyllithium to Naphthalenecarboxylic Acid BHA Ester<\/a><\/p>\n
Mitsuru Shindo, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Chem. Pharm. Bull.<\/i> 2009<\/b>, 57<\/i> (7), 752–<\/font>754.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Accessing the Amide Functionality by the Mild and Low-Cost Oxidation of Imine.<\/a><\/p>\n
Magdi A. Mohamed, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Tetrahedron Lett.<\/i> 2009<\/b>, 50<\/i> (26), 3436–<\/font>3438.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Total Synthesis of (–<\/font>)-Lycorine and (–<\/font>)-2-epi<\/i>-Lycorine by Asymmetric Conjugate Addition Cascade.<\/a><\/p>\n
Ken-ichi Yamada, Mitsuaki Yamashita, Takaaki Sumiyoshi, Katsumi Nishimura, and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2009<\/b>, 11<\/i> (7), 1631–<\/font>1633.
\n
\n Synfacts<\/i> 2009<\/b>, (10), 1066.<\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Dimethylzinc Initiated Radical Reactions (Review).<\/a><\/p>\n
Tito Akindele, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Acc. Chem. Res.<\/i> 2009<\/b>, 42<\/i> (2), 345–<\/font>355.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Tandem Conjugate Addition–<\/font>Aldol Cyclization of 2-Formylbenzylidenemalonate with Ether Radicals by the Mediation of Dimethylzinc.<\/a><\/p>\n
Ken-ichi Yamada, Masaru Maekawa, Tito Akindele, Yasutomo Yamamoto, Mayu Nakano, and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2009<\/b>, 65<\/i> (4), 903–<\/font>908.<\/dd>\n<\/td>\n<\/tr>\n
\n 2008<\/b><\/font>\n <\/td>\n\n Chemoselective Conjugate Addition of Dimethylzinc-Mediated Ether and Acetal Radicals to Alkylidenemalonates and Asymmetric Reactions.<\/a><\/p>\n
Ken-ichi Yamada, Masaru Maekawa, Tito Akindele, Mayu Nakano, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n J. Org. Chem.<\/i> 2008<\/b>, 73<\/i> (24), 9535–<\/font>9538.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Tin-free Radical Addition of Acyloxymethyl to Imines.<\/a><\/p>\n
Ken-ichi Yamada, Mayu Nakano, Masaru Maekawa, Tito Akindele, and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2008<\/b>, 10<\/i> (17), 3805–<\/font>3808.
\n
\n Synfacts<\/i> 2008<\/b>, (12), 1323.<\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
\n <\/b><\/font>\n <\/td>\n\n Copper-Catalyzed Asymmetric Allylic Substitution with Aryl and Ethyl Grignard Reagents.<\/a><\/p>\n
Khalid B. Selim, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Chem. Commun.<\/i> 2008<\/b>, (41), 5140–<\/font>5142.<\/dd>\n<\/td>\n<\/tr>\n
\n
\n <\/b><\/font>\n <\/td>\n		\n Copper-catalyzed Asymmetric Alkylation of Imines with Dialkylzinc and Related Reactions (Review).<\/a><\/p>\n
Ken-ichi Yamada and Kiyoshi Tomioka,
\n Chem. Rev.<\/i> 2008<\/b>, 108<\/i> (8), 2874–<\/font>2886.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Conjugate Addition of THF-2-yl Radical with \u03b1,\u03b2-Unsaturated N<\/i>-Tosyl Imines Using a Dimethylzinc–<\/font>Air Initiator.<\/a><\/p>\n
Ken-ichi Yamada, Hiroyuki Umeki, Masaru Maekawa, Yasutomo Yamamoto, Tito Akindele, Mayu Nakano, and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2008<\/b>, 64<\/i> (30-31), 7258–<\/font>7265.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n C<\/i>2<\/sub> Symmetric Chiral NHC Ligand for Asymmetric Quaternary Carbon Constructing Copper-Catalyzed Conjugate Addition of Grignard Reagents
\n to 3-Substituted Cyclohexenones.<\/a><\/p>\n
Yasumasa Matsumoto, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n J. Org. Chem.<\/i> 2008<\/b>, 73<\/i> (12), 4578–<\/font>4581.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Base-Induced Sequential Cyclization-Rearrangement of Enantioenriched 3-Aminoalkanoates to Five- and Seven-Membered Lactam.<\/a><\/p>\n
Takeo Sakai, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Chem. Asian J.<\/i> 2008<\/b>, 3<\/i> (8), 1486–<\/font>1493.<\/dd>\n<\/td>\n<\/tr>\n
\n
\n <\/b><\/font>\n <\/td>\n		\n Amidophosphane–<\/font>Copper(I)-Catalyzed Asymmetric Conjugate Addition of Dialkylzinc Reagents to Racemic 6-Substituted Cyclohexenones to Form 2,5-Di- and 2,2,5-Trisubstituted Cyclohexanones<\/a><\/p>\n
Khalid Selim, Takahiro Soeta, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Chem. Asian J.<\/i> 2008<\/b>, 3<\/i> (2), 342–<\/font>350.<\/dd>\n<\/td>\n<\/tr>\n
\n 2006<\/b><\/font>\n <\/td>\n\n Asymmetric Radical Addition of Ethers to Enantiopure N<\/i>–p<\/i>-Toluenesulfinyl Aldimines Mediated by Dimethylzinc-Air.<\/a><\/p>\n
Tito Akindele, Yasutomo Yamamoto, Masaru Maekawa, Hiroyuki Umeki, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2006<\/b>, 8<\/i> (25), 5729–<\/font>5732.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Efficient Catalytic Asymmetric Synthesis of trans-2-substituted 5-Arylcyclohexanones by Rhodium-Catalyzed Conjugate Arylation of Racemic 6-Substituted Cyclohexenones.<\/a><\/p>\n
Qian Chen, Takahiro Soeta, Masami Kuriyama, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Adv. Synth. Catal.<\/i> 2006<\/b>, 348<\/i> (18), 2604–<\/font>2608.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Tin-free Intermolecular Addition of Primary Alkyls to Imines via Dimethylzinc-Air Radical Process.<\/a><\/p>\n
Ken-ichi Yamada, Yasutomo Yamamoto, Masaru Maekawa, Tito Akindele, Hiroyuki Umeki and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2006<\/b>, 8<\/i> (1), 87–<\/font>89.<\/dd>\n<\/td>\n<\/tr>\n
\n 2005<\/b><\/font>\n <\/td>\n\n Asymmetric Mannich-Type Addition of Lithium Glycolates to Imines Producing 3-Hydroxy-4-Phenylazetidin-2-Ones. (Prof. Kenji Koga’s Memorial issue)<\/i><\/a><\/p>\n
Hiroki Fujieda, Seiji Hata, Ken-ichi Yamada and Kiyoshi Tomioka,
\n Heterocycles <\/i>2005<\/b>, 66<\/i>, 611–<\/font>619.<\/dd>\n<\/td>\n<\/tr>\n
\n
\n <\/b><\/font>\n <\/td>\n		\n Asymmetric Synthesis of 5-Arylcyclohexenones by Rhodium(I)-Catalyzed Conjugate Arylation of Racemic 5-(Trimethylsilyl)cyclohexenone with Arylboronic Acids.<\/a><\/p>\n
Qian Chen, Masami Kuriyama, Takahiro Soeta, Xinyu Hao, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Org. Lett<\/i>. 2005<\/b>, 7<\/i> (20), 4439–<\/font>4441.<\/dd>\n<\/td>\n<\/tr>\n
\n
\n <\/b><\/font>\n <\/td>\n		\n Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1R<\/i>,2R<\/i>)-2-Dimethylamino-1,2-diphenylethanol.<\/a><\/p>\n
Mitsuaki Yamashita, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Adv. Synth. Catal<\/i>. 2005<\/b>, 347<\/i> (11-13), 1649–<\/font>1652.<\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Chiral Amidophosphane–<\/font>Copper Catalyzed Asymmetric Conjugate Addition of Dialkylzinc Reagents to Nitroalkenes.<\/a><\/p>\n
Fanny Valleix, Kazushige Nagai, Takahiro Soeta, Masami Kuriyama, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2005<\/b>, 61<\/i> (31), 7420–<\/font>7424.<\/dd>\n<\/td>\n<\/tr>\n
\n
\n <\/b><\/font>\n <\/td>\n		\n Chiral Amino Alcohol-Mediated Asymmetric Conjugate Addition of Arylalkynes to Nitroolefins.<\/a><\/p>\n
Mitsuaki Yamashita, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Org. Lett<\/i>. 2005<\/b>, 7<\/i>i> (12), 2369–<\/font>2371.<\/dd>\n<\/td>\n<\/tr>\n
\n
\n <\/b><\/font>\n <\/td>\n		\n Mechanistic Aspects of Thiyl Radical-Promoted Acyl Radical Cyclization of Formylenoate – Cyclization versus Oxidation.<\/a><\/p>\n
Kazuya Yoshikai, Tomoharu Hayama, Katsumi Nishimura, Ken-Ichi Yamada, and Kiyoshi Tomioka,
\n Chem. Pharm. Bull<\/i>. 2005<\/b>, 53<\/i> (5), 586–<\/font>588.
\n Cover Figure<\/i><\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
\n
\n <\/b><\/font>\n <\/td>\n		\n Thiol-Catalyzed Acyl Radical Cyclization of Alkenals.<\/a><\/p>\n
Kazuya Yoshikai, Tomoharu Hayama, Katsumi Nishimura, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n J. Org. Chem.<\/i> 2005<\/b>, 70<\/i> (2), 681–<\/font>683. <\/dd>\n<\/td>\n<\/tr>\n
\n <\/td>\n\n Dimethylzinc-InitiatedRadical Reaction of Cyclic Ethers with Arylamines, Alkoxyamines, and Dialkylhydrazines.<\/a><\/p>\n
Yasutomo Yamamoto, Masaru Maekawa, Tito Akindele, Ken-ichi Yamada and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2005<\/b>, 61<\/i> (2), 379–<\/font>384. <\/dd>\n<\/td>\n<\/tr>\n
\n 2004<\/b><\/font>\n <\/td>\n\n Structure Tuning of Lithium Amide for Asymmetric 1,4-Addition to Cinnamate and Subsequent Demasking.<\/a><\/p>\n
Takeo Sakai, Masahiro Doi, Yoshito Kawamoto, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Tetrahedron Lett<\/i>. 2004<\/b>, 45<\/i> (50), 9261–<\/font>9263.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Radical Reactions Initiated by Diorganozinc (Review).<\/p>\n
Ken-ichi Yamada, Yasutomo Yamamoto and Kiyoshi Tomioka,
\n J. Synth. Org. Chem. Jpn.<\/i> 2004<\/b>, 62<\/i> (11), 1158–<\/font>1165.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Direct Aminoalkylation of Cycloalkanes through Dimethylzinc-Initiated Radical Process.<\/a><\/p>\n
Ken-ichi Yamada, Yasutomo Yamamoto, Masaru Maekawa, Jingbo Chen, and Kiyoshi Tomioka,
\n Tetrahedron Lett.<\/i> 2004<\/b>, 45<\/i> (35), 6595–<\/font>6597.
\n Cover Figure<\/i><\/font>
\n <\/a><\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n N<\/i>-Allyl-N<\/i>–tert<\/i>-butyldimethylsilylamine for Chiral Ligand-Controlled Asymmetric Conjugate Addition to tert<\/i>-Butyl Alkenoates.<\/a><\/p>\n
Hirohisa Doi, Takeo Sakai, Ken-ichi Yamada and Kiyoshi Tomioka,
\n Chem. Commun.<\/i> 2004<\/b>, (16), 1850–<\/font>1851.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Catalytic Enhancement Effect of a Chiral Ligand on the Asymmetric Mannich-Type Reactions of Menthyl Alkanoates with Aldimines<\/a> (Prof. Teruaki Mukaiyama issue).<\/p>\n
Seiji Hata, Tetsuo Iwasawa, Mayu Iguchi, Ken-ichi Yamada and Kiyoshi Tomioka,
\n Synthesis<\/i> 2004<\/b>, (9), 1471–<\/font>1475.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Lithium Amide-Assisted Asymmetric Mannich-Type Reactions of Menthyl Acetate with PMP-Aldimines.<\/a><\/p>\n
Seiji Hata, Mayu Iguchi, Tetsuo Iwasawa, Ken-ichi Yamada and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2004<\/b>, 6<\/i> (11), 1721–<\/font>1723.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Improved Asymmetric Synthesis of Dopamine D1 Full Agonist, Dihydrexidine, Employing Chiral Ligand-Controlled Asymmetric Conjugate Addition of Aryllithium to a Nitroalkene.<\/a><\/p>\n
Mitsuaki Yamashita, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Tetrahedron<\/i> 2004<\/b>, 60<\/i> (19), 4237–<\/font>4242.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Efficient Synthesis of (±)-γ-Lycorane Employing Stereoselective Conjugate Addition to Nitroolefin.<\/a><\/p>\n
Tomohisa Yasuhara, Emi Osafune, Katsumi Nishimura, Mitsuaki Yamashita, Ken-ichi Yamada, Osamu Muraoka, and Kiyoshi Tomioka,
\n Tetrahedron Lett<\/i>. 2004<\/b>, 45<\/i> (15), 3043–<\/font>3045.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Construction of Arene-Fused-Piperidine Motifs by Asymmetric Addition of 2-Trityl-oxymethylaryllithiums to Nitroalkenes: the Asymmetric Synthesis of a Dopamine D1 Full Agonist, A-86929<\/a>.<\/p>\n
Mitsuaki Yamashita, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n J. Am. Chem. Soc.<\/i> 2004<\/b>, 126<\/i> (7), 1954–<\/font>1955.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Introduction of Functionalized C1, C2, and C3 Units to Imines through the Dimethylzinc-Air-Initiated Radical Addition.<\/a><\/p>\n
Ken-ichi Yamada, Yasutomo Yamamoto, Masaru Maekawa, and Kiyoshi Tomioka,
\n J. Org. Chem.<\/i> 2004<\/b>, 69<\/i> (5), 1531–<\/font>1534.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Unexpected reaction of a dimethylzinc-generated THF radical with aldehydes.<\/a><\/p>\n
Yasutomo Yamamoto, Ken-ichi Yamada and Kiyoshi Tomioka,
\n Tetrahedron Lett<\/i>. 2004<\/b>, 45<\/i> (4), 795–<\/font>797.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Addition of Organolithium Reagents to Double Bonds.<\/p>\n
Hiroshi Yamataka, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n The Chemistry of Organolithium Compounds<\/i>; Rappoport, Z.; Marek, I., Eds; Wiley, 2004; Part 1, Chapter 14.<\/dd>\n<\/td>\n<\/tr>\n
\n 2003<\/b><\/font>\n <\/td>\n\n Initiator-Dependent Chemoselective Addition of THF Radical to Aldehyde and Aldimine and Its Application to a Three-Component Reaction.<\/a><\/p>\n
Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2003<\/b>, 5<\/i> (10), 1797–<\/font>1799.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Total Synthesis of (±)-α- and β-Lycoranes by Sequential Chemoselective Conjugate Addition-Stereoselective Nitro-Michael Cyclization of an ω-Nitro-α,β,ψ,ω-unsaturated Ester.<\/a><\/p>\n
Tomohisa Yasuhara, Katsumi Nishimura, Mitsuaki Yamashita, Naoshi Fukuyama, Ken-ichi Yamada, Osamu Muraoka, and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2003<\/b>, 5<\/i> (7), 1123–<\/font>1126.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Chiral Ligand-Controlled Asymmetric Conjugate Addition of Lithium Amides to Enoates.<\/a><\/p>\n
Hirohisa Doi, Takeo Sakai, Mayu Iguchi, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n J. Am. Chem. Soc.<\/i> 2003<\/b>, 125<\/i> (10), 2886–<\/font>2887. <\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Enantioselective Conjugate Addition and 1,2-Addition to C=N of Organolithium Reagents.<\/p>\n
Mayu Iguchi, Ken-ichi Yamada and Kiyoshi Tomioka,
\n Organolithiums in Enantioselective Synthesis<\/i>; D. M. Hodgson, Ed; Topics in Organometallic Chemistry 5; Springer, 2003; pp 37–<\/font>59.<\/dd>\n<\/td>\n<\/tr>\n
\n 2002<\/b><\/font>\n <\/td>\n\n Radical Addition of Ethers to Imines Initiated by Dimethylzinc.<\/a><\/p>\n
Ken-ichi Yamada, Hidetaka Fujihara, Yasutomo Yamamoto, Yoshihisa Miwa, Tooru Taga, and Kiyoshi Tomioka,
\n Org. Lett.<\/i> 2002<\/b>, 4<\/i>, 3509–<\/font>3511. <\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Hemilabile Amidomonophosphine Ligand–<\/font>Rhodium(I) Complex-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Cycloalkenones.<\/a><\/p>\n
Masami Kuriyama, Kazushige Nagai, Ken-ichi Yamada, Yoshinao Miwa, Tooru Taga, and Kiyoshi Tomioka,
\n J. Am. Chem. Soc.<\/i> 2002<\/b>, 124<\/i> (30), 8932–<\/font>8939.<\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n Efficient Chiral Amidophosphine Ligand for Copper-catalyzed Asymmetric Addition of Diethylzinc to N<\/i>-Sulfonylimines.<\/a><\/p>\n
Kazushige Nagai, Hidetaka Fujihara, Masami Kuriyama, Ken-ichi Yamada and Kiyoshi Tomioka,
\n Chem. Lett.<\/i> 2002<\/b>, (1), 8–<\/font>9. <\/dd>\n<\/td>\n<\/tr>\n
\n 2001<\/b><\/font>\n <\/td>\n\n Electronic and Steric Control in Regioselective Addition Reactions of Organolithium Reagents with Enaldimines.<\/a><\/p>\n
Kiyoshi Tomioka, Yoshito Shioya, Yasuo Nagaoka, and Ken-ichi Yamada,
\n J. Org. Chem.<\/i> 2001<\/b>, 66<\/i> (21), 7051–<\/font>7054. <\/dd>\n<\/td>\n<\/tr>\n
<\/td>\n\n The First Asymmetric Synthesis of a Dopamine D1 Agonist, Dihydrexidine, Employing Asymmetric Conjugate Addition Technology.<\/a><\/p>\n
Yasutomi Asano, Mitsuaki Yamashita, Kazushige Nagai, Masami Kuriyama, Ken-ichi Yamada, and Kiyoshi Tomioka,
\n Tetrahedron Lett.<\/i> 2001<\/b>, 42<\/i> (48), 8493–<\/font>8495. <\/dd>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

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