{"id":13,"date":"2024-04-13T10:40:51","date_gmt":"2024-04-13T01:40:51","guid":{"rendered":"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/?page_id=13"},"modified":"2026-04-06T13:12:37","modified_gmt":"2026-04-06T04:12:37","slug":"%e7%a0%94%e7%a9%b6%e3%83%86%e3%83%bc%e3%83%9e","status":"publish","type":"page","link":"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/%e7%a0%94%e7%a9%b6%e3%83%86%e3%83%bc%e3%83%9e\/","title":{"rendered":"\u7814\u7a76\u30c6\u30fc\u30de"},"content":{"rendered":"<h2>\u7814\u7a76\u30c6\u30fc\u30de<\/h2>\n<p>\u9ad8\u5ea6\u5316\u3059\u308b\u533b\u7642\u306e\u4e2d\u3067\u533b\u85ac\u54c1\u306e\u679c\u305f\u3059\u3079\u304d\u5f79\u5272\u304c\u5927\u304d\u304f\u306a\u308b\u4e2d\u3067\u3001\u305d\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u306e\u8cea\u4fdd\u8a3c\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u85ac\u7269\u52d5\u614b\u306f\u751f\u4f53\u306b\u6295\u4e0e\u3055\u308c\u305f\u533b\u85ac\u54c1\u306e\u5438\u53ce\u3001\u5206\u5e03\u3001\u4ee3\u8b1d\u3001\u6392\u6cc4\u3068\u3044\u30464\u3064\u306e\u4e3b\u306a\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u3063\u3066\u69cb\u6210\u3055\u308c\u3001\u5404\u30d7\u30ed\u30bb\u30b9\u306e\u30c8\u30fc\u30bf\u30eb\u30d0\u30e9\u30f3\u30b9\u304c\u6a19\u7684\u304a\u3088\u3073\u6a19\u7684\u4ee5\u5916\u306e\u7d44\u7e54\u30fb\u7d30\u80de\u3067\u306e\u85ac\u7269\u6fc3\u5ea6\u63a8\u79fb\u3092\u6c7a\u5b9a\u3057\u3001\u85ac\u52b9\u3084\u526f\u4f5c\u7528\u306e\u767a\u73fe\u306b\u5bc6\u63a5\u306b\u5f71\u97ff\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u5275\u85ac\u3067\u306f\u52d5\u614b\u7279\u6027\u306e\u512a\u308c\u305f\u5019\u88dc\u7269\u8cea\u306e\u63a2\u7d22\u304a\u3088\u3073\u52d5\u614b\u306e\u5236\u5fa1\u304c\u3001\u81e8\u5e8a\u3067\u306f\u85ac\u7269\u52d5\u614b\u306e\u500b\u4f53\u9593\u5909\u52d5\u306b\u57fa\u3065\u304f\u6295\u4e0e\u8a08\u753b\u306e\u6700\u9069\u5316\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u6570\u7406\u6cbb\u7642\u85ac\u5b66\u5206\u91ce\u3067\u306f\u3001\u85ac\u7269\u52d5\u614b\u30fb\u85ac\u52b9\u30fb\u6bd2\u6027\uff0f\u526f\u4f5c\u7528\u306b\u95a2\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5b9a\u91cf\u7684\u306b\u89e3\u6790\u3057\u3001\u533b\u85ac\u54c1\u306e\u8a2d\u8a08\u3084\u9069\u6b63\u4f7f\u7528\u306b\u8cc7\u3059\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u4ee5\u4e0b\u306b\u3001\u5f53\u5206\u91ce\u306e\u7814\u7a76\u30c6\u30fc\u30de\u3068\u5177\u4f53\u7684\u306a\u7814\u7a76\u5185\u5bb9\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n<ol>\n<li>\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u3092\u5229\u7528\u3057\u305f\u85ac\u7269\u52d5\u614b\u30fb\u6bd2\u6027\u8a55\u4fa1\u30b7\u30b9\u30c6\u30e0\u306e\u958b\u767a<\/li>\n<li>\u81e8\u5e8a\u60c5\u5831\u89e3\u6790\u306b\u3088\u308b\u85ac\u52b9\u304a\u3088\u3073\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u306e\u4e88\u6e2c<\/li>\n<li>AI\uff0f\u6a5f\u68b0\u5b66\u7fd2\u3092\u99c6\u4f7f\u3057\u305f\u85ac\u7269\u52d5\u614b\u306e\u4e88\u6e2c\u6cd5\u306e\u958b\u767a<\/li>\n<li>\u30aa\u30df\u30af\u30b9\u60c5\u5831\u306b\u57fa\u3065\u304f\u75be\u60a3\u306e\u767a\u75c7\u6a5f\u5e8f\u89e3\u660e\u3068\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u304a\u3088\u3073\u4e88\u9632\u85ac\u306e\u958b\u767a<\/li>\n<li>\u74b0\u5883\u56e0\u5b50\u306b\u3088\u308b\u4e0a\u76ae\u6027\u708e\u75c7\u6a5f\u5e8f\u89e3\u660e\u3068\u6cbb\u7642\u6cd5\u306e\u958b\u767a<\/li>\n<li>\u00a0\u526f\u4f5c\u7528\u767a\u73fe\u306e\u5206\u5b50\u52d5\u614b\u5b66\u7684\u30fb\u85ac\u7406\u5b66\u7684\u89e3\u6790\u3068\u4e88\u9632\u30fb\u6cbb\u7642\u6cd5\u3078\u306e\u5c55\u958b<\/li>\n<\/ol>\n<p>\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>1. \u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u3092\u5229\u7528\u3057\u305f\u85ac\u7269\u52d5\u614b\u30fb\u6bd2\u6027\u8a55\u4fa1\u30b7\u30b9\u30c6\u30e0\u306e\u958b\u767a\u7814\u7a76<\/h4>\n<p>\u5275\u85ac\u7814\u7a76\u306b\u304a\u3051\u308b\u85ac\u52b9\u30fb\u6bd2\u6027\u8a55\u4fa1\u3067\u306f\u3001\u30d2\u30c8\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u305fin vitro\u5b9f\u9a13\u304c\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5f93\u6765\u306e\uff12D\u57f9\u990a\u7cfb\u3067\u306f\u3001in vivo\u5b9f\u9a13\u3068\u306e\u9593\u306b\u4e56\u96e2\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u6700\u8fd1\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\uff08\u81d3\u5668\u30c1\u30c3\u30d7\uff09\u306f\u3001\u5fae\u5c0f\u7a7a\u9593\u3067\u5358\u4e00\u306e\u81d3\u5668\u6a5f\u80fd\u3084\u69cb\u9020\u3092\u518d\u73fe\u3057\u305f\u308a\u3001\u8907\u6570\u306e\u81d3\u5668\u30e2\u30c7\u30eb\u3092\u9023\u7d50\u3057\u3066\u85ac\u7269\u306e\u5438\u53ce\u30fb\u4ee3\u8b1d\u306a\u3069\u306e\u4f53\u5185\u52d5\u614b\u3092\u6a21\u5023\u3057\u305f\u308a\u3059\u308bin vitro\u5b9f\u9a13\u6280\u8853\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u79c1\u305f\u3061\u306f\u3001\u85ac\u7269\u5438\u7740\u6027\u3092\u8efd\u6e1b\u3057\u305f\u308a\u4f38\u5c55\u523a\u6fc0\u3092\u5370\u52a0\u3057\u305f\u308a\u3057\u305f\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u8907\u6570\u306e\u7d30\u80de\u7a2e\u30923D\u74b0\u5883\u3067\u704c\u6d41\u57f9\u990a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30d2\u30c8\u7d44\u7e54\u3067\u306e\u85ac\u7269\u52d5\u614b\u3084\u6bd2\u6027\u3092\u30c1\u30c3\u30d7\u4e0a\u3067\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-95 aligncenter\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2024\/05\/homepage1.jpg\" alt=\"\" width=\"704\" height=\"191\" \/><\/p>\n<p style=\"text-align: center;\">Wang M, et al, Application of perfluoropolyether elastomers in microfluidic drug metabolism assays. <em>Int J Pharm<\/em>, 627, 122253 (2022).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-150 aligncenter\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2025\/05\/acs2024.png\" alt=\"\" width=\"665\" height=\"271\" \/><\/p>\n<p style=\"text-align: center;\">Wang M, et al, Perfluoropolyether-based gut-liver-on-a-chip for the evaluation of first-pass metabolism and oral bioavailability of drugs. <em><strong>ACS Biomater Sci Eng<\/strong><\/em>, 10(7), 4635-4644 (2024).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-174 aligncenter\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/ToxLett-1024x379.png\" alt=\"\" width=\"662\" height=\"245\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/ToxLett-1024x379.png 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/ToxLett-300x111.png 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/ToxLett-768x284.png 768w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/ToxLett-1536x569.png 1536w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/ToxLett.png 1914w\" sizes=\"auto, (max-width: 662px) 100vw, 662px\" \/><\/p>\n<p style=\"text-align: center;\">Wang M, et al, Protective role of hepatic non-parenchymal cells against drug-induced hepatocyte toxicity using perfluoropolyether-based microfluidic devices. <em><strong>Toxicol Lett<\/strong><\/em>, 407, 24-31 (2025).<\/p>\n<h4>2. \u81e8\u5e8a\u60c5\u5831\u89e3\u6790\u306b\u3088\u308b\u85ac\u52b9\u304a\u3088\u3073\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u306e\u4e88\u6e2c<\/h4>\n<p>\u533b\u85ac\u54c1\u306e\u526f\u4f5c\u7528\u306f\u3001\u305d\u308c\u304c\u8d77\u304d\u305f\u60a3\u8005\u306b\u5bfe\u3057\u3066\u81e8\u5e8a\u7684\u306a\u8ca0\u62c5\u3092\u3082\u305f\u3089\u3059\u4e0a\u3001\u533b\u7642\u73fe\u5834\u3084\u88fd\u85ac\u4f01\u696d\u306b\u3082\u793e\u4f1a\u7684\u3001\u7d4c\u6e08\u7684\u5206\u62c5\u3092\u5f37\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u5e02\u8ca9\u5f8c\u306e\u5b89\u5168\u6027\u60c5\u5831\u306b\u95a2\u3059\u308b\u5927\u898f\u6a21\u30c7\u30fc\u30bf\u3092\u75ab\u5b66\u7684\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u526f\u4f5c\u7528\u767a\u73fe\u306b\u304a\u3051\u308b\u7279\u5fb4\u91cf\u3092\u898b\u51fa\u3057\u3001\u30ea\u30b9\u30af\u4f4e\u6e1b\u30fb\u56de\u907f\u306b\u5411\u3051\u305f\u884c\u52d5\u8a08\u753b\u3092\u7acb\u6848\u3067\u304d\u307e\u3059\u3002\u73fe\u5728\u3001\u809d\u6bd2\u6027\u306e\u3042\u308b\u85ac\u7269\u3092\u7db2\u7f85\u7684\u306b\u63a2\u7d22\u3057\u3066\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u898b\u51fa\u3057\u3001\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u5fdc\u7528\u3057\u3088\u3046\u3068\u3059\u308b\u7814\u7a76\u3092\u5c55\u958b\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u306f\u60c5\u5831\u53ce\u96c6\u3082\u91cd\u8981\u3067\u3042\u308a\u3001\u751f\u6210AI\u3092\u7528\u3044\u305f\u6587\u732e\u60c5\u5831\u306e\u30c6\u30ad\u30b9\u30c8\u30de\u30a4\u30cb\u30f3\u30b0\u3082\u6709\u52b9\u306a\u30c4\u30fc\u30eb\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<h4><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-97 aligncenter\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2024\/05\/homepage2-scaled.jpg\" alt=\"\" width=\"724\" height=\"225\" \/><\/h4>\n<p style=\"text-align: center;\">Zhang Q, et al. CREB is a potential marker associated with drug-induced liver injury: identification and validation through transcriptome database analysis. <em><strong>J Toxicol Sci<\/strong><\/em>, 47(8), 337-348 (2022).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-173 aligncenter\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/CharGPT_IJP-1024x291.png\" alt=\"\" width=\"764\" height=\"217\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/CharGPT_IJP-1024x291.png 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/CharGPT_IJP-300x85.png 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/CharGPT_IJP-768x218.png 768w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/CharGPT_IJP-1536x436.png 1536w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2026\/04\/CharGPT_IJP-2048x581.png 2048w\" sizes=\"auto, (max-width: 764px) 100vw, 764px\" \/><\/p>\n<p style=\"text-align: center;\">Alkarmouty M, et al. Harnessing large language models for structured extraction of cytochrome P450-substance interactions from biomedical texts. <em><strong>Int J Pharm<\/strong><\/em>, 684, 126111 (2025).<\/p>\n<h4>3. AI\uff0f\u6a5f\u68b0\u5b66\u7fd2\u3092\u99c6\u4f7f\u3057\u305f\u85ac\u7269\u52d5\u614b\u306e\u4e88\u6e2c\u6cd5\u306e\u958b\u767a<\/h4>\n<p>\u85ac\u7269\u306e\u4f53\u5185\u52d5\u614b\u306f\u69d8\u3005\u306a\u8981\u56e0\u306b\u3088\u3063\u3066\u652f\u914d\u3055\u308c\u307e\u3059\u3002\u5316\u5b66\u69cb\u9020\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u7269\u6027\u304c\u5909\u308f\u3063\u305f\u308a\u3001\u85ac\u7269\u4ee3\u8b1d\u9175\u7d20\u3084\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306b\u3088\u308b\u5206\u5b50\u8a8d\u8b58\u3084\u53cd\u5fdc\u6027\u304c\u5909\u308f\u3063\u305f\u308a\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u540c\u3058\u533b\u85ac\u54c1\u3092\u6295\u4e0e\u3057\u3066\u3082\u60a3\u8005\u9593\u3067\u306e\u4f53\u5185\u52d5\u614b\u306e\u500b\u4f53\u9593\u5909\u52d5\u304c\u307f\u3089\u308c\u3001\u3053\u308c\u3089\u306b\u306f\u60a3\u8005\u306e\u4f53\u683c\u3001\u809d\uff0f\u814e\u75be\u60a3\u306e\u6709\u7121\u3001\u907a\u4f1d\u591a\u578b\u306e\u9055\u3044\u306a\u3069\u304c\u5f71\u97ff\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6f5c\u5728\u7684\u306a\u30d1\u30bf\u30fc\u30f3\u3092AI\uff0f\u6a5f\u68b0\u5b66\u7fd2\u306b\u3088\u3063\u3066\u30e2\u30c7\u30eb\u5316\u3067\u304d\u308c\u3070\u533b\u85ac\u54c1\u958b\u767a\u306e\u52b9\u7387\u5316\u3084\u81e8\u5e8a\u3067\u306e\u500b\u5225\u5316\u6cbb\u7642\u8a08\u753b\u306e\u7acb\u6848\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u3001\u907a\u4f1d\u7684\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u4f7f\u3063\u3066\u30c7\u30fc\u30bf\u99c6\u52d5\u30e2\u30c7\u30eb\u5f0f\u3092\u9032\u5316\u7684\u306b\u63a2\u7d22\u3059\u308b\u65b9\u6cd5\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306aAI\/\u6a5f\u68b0\u5b66\u7fd2\u30c4\u30fc\u30eb\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-99 aligncenter\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2024\/05\/homepage3.jpg\" alt=\"\" width=\"763\" height=\"174\" \/><\/h4>\n<p style=\"text-align: center;\">Ota R, et al. Prediction of HIV drug resistance based on the 3D protein structure: Proposal of molecular field mapping.<em><strong> PLoS One<\/strong><\/em>, 16(8), e0255693 (2021).<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-159 aligncenter\" src=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2025\/05\/ijp2025_1.png\" alt=\"\" width=\"782\" height=\"233\" srcset=\"https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2025\/05\/ijp2025_1.png 1800w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2025\/05\/ijp2025_1-300x89.png 300w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2025\/05\/ijp2025_1-1024x305.png 1024w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2025\/05\/ijp2025_1-768x229.png 768w, https:\/\/www.pharm.kyoto-u.ac.jp\/quantpharm\/files\/2025\/05\/ijp2025_1-1536x457.png 1536w\" sizes=\"auto, (max-width: 782px) 100vw, 782px\" \/>Doi Y, et al. Prediction of plasma concentration-time profiles in mice using deep neural network integrated with pharmacokinetic models. <em><strong>Int J Pharm<\/strong><\/em>, 676, 125608 (2025).<\/p>\n<h4>4. 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