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主な業績 2018

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【原著論文】


" Analysis of physicochemical interaction of Aβ40 with a GM1 ganglioside-containing lipid membrane "

Majid Vahed, Saburo Neya, Katsumi Matsuzaki, and Tyuji Hoshino

J. Phys. Chem. B., 122, 3771-3781 (2018)


" Simulation study on the complex conformations of Aβ42 peptides on the GM1 ganglioside-containing lipid membrane "

Majid Vahed, Saburo Neya, Katsumi Matsuzaki, and Tyuji Hoshino

Chem. Pharm. Bull., 66,170-177(2018)
[Highlighted Paper selected by Editor-in-Chief]


" Not oligomers but amyloids are cytotoxic in the membrane-mediated amyloidogenesis by amyloid-β peptide "

Naoya Itoh, Eri Takada, Kaori Okubo, Yoshiaki Yano, Masaru Hoshino, Akira Sasaki, Masataka Kinjo, and Katsumi Matsuzaki

ChemBioChem, 19,430-433(2018)


" High performance plasma amyloid-β biomarkers for Alzheimer's disease "

Akinori Nakamura, Naoki Kaneko, Victor L. Villemagne, Takashi Kato, James Doecke, Vincent Dore, Chris Fowler, Qiao-Xin Li, Ralph Martins, Christopher Rowe, Taisuke Tomita, Katsumi Matsuzaki, Kenji Ishii, Kazunari Ishii, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Colin L. Masters, and Katsuhiko Yanagisawa

Nature, 554,249-254(2018)


" Trace amounts of pyroglutaminated Aβ-(3?42) enhance aggregation of Aβ-(1?42) on neuronal membranes at physiological concentrations: FCS analysis of cell surface "

Yoshiaki Yano, An Takeno, and Katsumi Matsuzaki

Biochim. Biophys. Acta 1860, 1603-1608 (2018)

【総説・単行本】


" Ganglioside-mediated assembly of amyloid β-protein:roles in Alzheimer's disease "

Katsumi Matsuzaki, Koichi Kato, and Katsuhiko Yanagisawa

Progress in Molecular Biology and Translational Science "Gangliosides in Health and Disease" ,Ronald L. Schnaar and Pablo H. H. Lopez, Eds., Chapter 14, Academic Press (2018)

【2018年度の招待講演等】


Katsumi Matsuzaki
"Toxic amyloid fibrils formed by amyloid beta-peptide on neuronal membranes: their mechanism of formation and structure"
10th International Peptide Symposium
Dec. 3-7, Kyoto

Katsumi Matsuzaki
"Monitoring aggregation and cytotoxicity by amyloid beta peptide on neuronal cells"
International Symposium on Pathomechanisms of Amyloid Diseases
Dec 20-21, Miami, U.S.A.



【2018年度の学会賞・財団助成等】


松崎 勝巳
「神経細胞膜を介した毒性型Aβアミロイドの形成・毒性発現機構
<<上原記念生命科学財団・平成30年度研究助成金>>《

森瀬 敬之
「膜貫通へリックス会合のsingle-pair FRET蛍光測定ーGXXXGモチーフにおけるグリシン残基の数及び位置の影響《
PPF2018若手奨励賞

矢野義明
「アミロイド前駆体タンパク質の切断制御に関わる自己会合状態の解明《
2018年度武田科学振興財団研究助成
薬学系研究助成






<研究概要>

1.抗菌性ペプチドの作用機構の解明と創薬への展開

2.アルツハイマー病発症機構の解明と予防・治療法の開発

3.膜タンパク質の構造形成原理の解明

4.Gタンパク質共役型受容体の機能制御法の開発

5. NMRによる蛋白質の動的立体構造解析
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