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【原著論文】
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Computational Study on the Assembly of Amyloid β-Peptides in the Hydrophobic Environment
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Liang Qu, Satoshi Fudo, Katsumi Matsuzaki, Tyuji Hoshino
Chem. Pharm. Bull., 67, 959-965 (2019)
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Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy
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Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miyata, and Masaru Hoshino
Biochim. Biophys. Acta, 1867, 813-820 (2019)
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Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues
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Naoto Tanishiki, Yoshiaki Yano, and Katsumi Matsuzaki
ChemBioChem, 20, 2109-2117 (2019) [Very Important Paper]
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Toxic amyloid tape: A novel mixed antiparallel/parallel β-sheet structure formed by Aβ on GM1 clusters
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Yuki Okada, Kaori Okubo, Keisuke Ikeda, Yoshiaki Yano, Masaru Hoshino, Yoshio Hayashi, Yoshiaki Kiso, Hikari Itoh-Watanabe, Akira Naito, and Katsumi Matsuzaki
ACS Chem. Neurosci.,
10, 563?572 (2019).
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【総説・単行本】
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天然変性タンパク質の新しい相互作用機構
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日比野 絵美, 星野 大
生物物理, 59, 202-204 (2019)
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Membrane Permeabilization Mechanisms
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Katsumi Matsuzaki
Advances in Experimental Medicine and Biology book series (volume 1117) Antimicrobial Peptides: Basics for Clinical Application, Katsumi Matsuzaki, Ed., Chapter 2, Springer (2019)
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Live-cell imaging of membrane proteins by a coiled-coil labeling method―Principles and applications
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Yoshiaki Yano and Katsumi Matsuzaki
Biochim. Biophys. Acta 1862, 1011-1017 (2019)
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【2019年度の招待講演等】 |
Katsumi Matsuzaki
"How does Aβ self-aggregate on and exert toxicity against neuronal cells?"
International Symposium on Pathomechanisms of Amyloid Diseases
Dec 18?20, Miami, USA
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Katsumi Matsuzaki
"Toxic Aβ amyloids formed on neuronal membranes: their mechanism of formation and structure"
日本薬学会第139年会 国際交流シンポジウム
3/21~23、千葉
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<研究概要>
1.抗菌性ペプチドの作用機構の解明と創薬への展開
2.アルツハイマー病発症機構の解明と予防・治療法の開発
3.膜タンパク質の構造形成原理の解明
4.Gタンパク質共役型受容体の機能制御法の開発
5. NMRによる蛋白質の動的立体構造解析
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