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主な業績 2019

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【原著論文】


" Computational Study on the Assembly of Amyloid β-Peptides in the Hydrophobic Environment "

Liang Qu, Satoshi Fudo, Katsumi Matsuzaki, Tyuji Hoshino

Chem. Pharm. Bull., 67, 959-965 (2019)


" Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy "

Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miyata, and Masaru Hoshino

Biochim. Biophys. Acta, 1867, 813-820 (2019)


" Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues "

Naoto Tanishiki, Yoshiaki Yano, and Katsumi Matsuzaki

ChemBioChem, 20, 2109-2117 (2019) [Very Important Paper]


" Toxic amyloid tape: A novel mixed antiparallel/parallel β-sheet structure formed by Aβ on GM1 clusters "

Yuki Okada, Kaori Okubo, Keisuke Ikeda, Yoshiaki Yano, Masaru Hoshino, Yoshio Hayashi, Yoshiaki Kiso, Hikari Itoh-Watanabe, Akira Naito, and Katsumi Matsuzaki

ACS Chem. Neurosci., 10, 563?572 (2019).

【総説・単行本】


" 天然変性タンパク質の新しい相互作用機構 "

日比野 絵美, 星野 大

生物物理, 59, 202-204 (2019)


" Membrane Permeabilization Mechanisms "

Katsumi Matsuzaki

Advances in Experimental Medicine and Biology book series (volume 1117) Antimicrobial Peptides: Basics for Clinical Application, Katsumi Matsuzaki, Ed., Chapter 2, Springer (2019)


" Live-cell imaging of membrane proteins by a coiled-coil labeling method―Principles and applications "

Yoshiaki Yano and Katsumi Matsuzaki

Biochim. Biophys. Acta 1862, 1011-1017 (2019)

【2019年度の招待講演等】


Katsumi Matsuzaki
"How does Aβ self-aggregate on and exert toxicity against neuronal cells?"
International Symposium on Pathomechanisms of Amyloid Diseases
Dec 18?20, Miami, USA




Katsumi Matsuzaki
"Toxic Aβ amyloids formed on neuronal membranes: their mechanism of formation and structure"
日本薬学会第139年会 国際交流シンポジウム
3/21~23、千葉 







<研究概要>

1.抗菌性ペプチドの作用機構の解明と創薬への展開

2.アルツハイマー病発症機構の解明と予防・治療法の開発

3.膜タンパク質の構造形成原理の解明

4.Gタンパク質共役型受容体の機能制御法の開発

5. NMRによる蛋白質の動的立体構造解析
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