Department of Molecular Microbiology
Division of Life Science
Graduate School of Pharmaceutical Sciences
Kyoto University

Japanese

　　[2010 - 2001]　　　　　　　　　　　　　　　　　　　[before 2000]＞＞>

• Hattori K, Nishikawa M, Watcharanurak K, Ikoma A, Kabashima K, Toyota H, Takahashi Y, Takahashi R, Watanabe Y, and Takakura Y. " Sustained exogenous expression of therapeutic levels of IFN-gamma ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization. " J Immunol . 2010;184(5):2729-2735. [Pubmed]

• Mitsui M, Nishikawa M, Zang L, Ando M, Hattori K, Takahashi Y, Watanabe Y, Takakura Y. " Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression. " J Gene Med . 2009;11(5):435-443. [Pubmed]

• Takahashi Y, Kaneda H, Takasuka N, Hattori K, Nishikawa M, Watanabe Y, Takakura Y. " Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells." Cancer Sci . 2008; 99(8):1650-5. [Pubmed]

• Abe M, Kuroda Y, Hirose M, Watanabe Y, Nakano M, Handa T. "Inhibition of autophosphorylation of epidermal growth factor receptor by small peptides in vitro." Br J Pharmacol. 2006;147(4):402-411. [Pubmed]

• Maruyama M, Kishimoto M, Ishida K, Watanabe Y, Nishikawa M, Masuda S, Sasaki R, Takakura Y. "Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells." Arch Biochem Biophys. 2005;438(2):174-181. [Pubmed]

• Kawaguchi H, Akazawa Y, Watanabe Y, Takakura Y. "Permeability modulation of human intestinal Caco-2 cell monolayers by interferons." Eur J Pharm Biopharm. 2005;59(1):45-50. [Pubmed]

• Watanabe Y. "Fifty years of interference." Nat Immunol. 2004;5(12):1193. [Pubmed]

• Nishio T, Maruyama M, Yoshida T, Watanabe Y, Nishikawa M, Takakura Y. "Secretion mode and subcellular localization of human interferon-beta exogenously expressed in porcine renal epithelial LLC-PK1 cells." Biol Pharm Bull. 2004;27(10):1653-1655. [Pubmed]

• Nakamura M, Yamaguchi S, Watanabe Y, Yamashita F, Takakura Y, Hashida M. "Exogenous expression of interferon-beta in cultured brain microvessel endothelial cells." Biol Pharm Bull. 2004;27(9):1441-1443. [Pubmed]

• Maruyama M, Nishio T, Yoshida T, Ishida C, Ishida K, Watanabe Y, Nishikawa M, Takakura Y. "Simultaneous detection of DsRed2-tagged and EGFP-tagged human beta-interferons in the same single cells." J Cell Biochem. 2004;93(3):497-502. [Pubmed]

• Nakamura M, Maruyama M, Yamashita F, Takakura Y, Hashida M, Watanabe Y. "Expression and visualization of a human interferon-beta-enhanced green fluorescent protein chimeric molecule in cultured cells." Biol Pharm Bull. 2004;27(3):411-414. [Pubmed]

• Maruyama M, Nishio T, Kato T, Yoshida T, Ishida C, Watanabe Y, Nishikawa M, Kaneda Y, Takakura Y. "Subcellular trafficking of exogenously expressed interferon-beta in Madin-Darby canine kidney cells." J Cell Physiol. 2004;201(1):117-125. [Pubmed]

• Kawaguchi H, Matsui Y, Watanabe Y, Takakura Y. "Effect of interferon-gamma on the pharmacokinetics of digoxin, a P-glycoprotein substrate, intravenously injected into the mouse." J Pharmacol Exp Ther. 2004;308(1):91-96. [Pubmed]

• Sakurai F, Terada T, Maruyama M, Watanabe Y, Yamashita F, Takakura Y, Hashida M. "Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model." Cancer Gene Ther. 2003;10(9):661-668. [Pubmed]

• Kobayashi N, Kuramoto T, Chen S, Watanabe Y, Takakura Y. "Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models." Mol Ther. 2002;6(6):737-744. [Pubmed]

• Nakanishi K, Watanabe Y, Maruyama M, Yamashita F, Takakura Y, Hashida M. "Secretion polarity of interferon-beta in epithelial cell lines." Arch Biochem Biophys. 2002;402(2):201-207. [Pubmed]

• Akazawa Y, Kawaguchi H, Funahashi M, Watanabe Y, Yamaoka K, Hashida M, Takakura Y. "Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes." J Pharm Sci. 2002;91(10):2110-2115. [Pubmed]

• Tanaka S, Sakata Y, Morimoto K, Tambe Y, Watanabe Y, Honda G, Tabata M, Oshima T, Masuda T, Umezawa T, Shimada M, Nagakura N, Kamisako W, Kashiwada Y, Ikeshiro Y. "Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1." Planta Med. 2001;67(2):108-113. [Pubmed]

Top of page

• Watanabe Y. "Transfection of interferon-gamma gene in animal tumors--a model for local cytokine production and tumor immunity." Semin Cancer Biol. 1992;3(1):43-46. [Pubmed]

• Y. Watanabe: Tumorigenicity and immunogenicity of IFN-γ producing tumor cells. In "Cytokine-induced tumor immunogenicity"(eds. G. Forni, R. Foa, A. Santoni & L. Frati ), pp. 233-247, Academic Press, London (1994) [Amazon]
• Y. Watanabe & Y. Kawade: Induction, production and purification of natural mouse IFN-α and -β. In "Lymphokines and interferons: a practical approach" (eds. M.J. Clemens, A.G. Morris & A.J.H. Gearing), pp. 1-14, IRL, Oxford (1987)
• K. Nagata, O. Ohara, H. Teraoka, N. Yoshida, Y. Watanabe & Y. Kawade: Production and purification of recombinant mouse interferon-γ from E. coli. In "Lymphokines and interferons: a practical approach" (eds. M.J. Clemens, A.G. Morris & A.J.H. Gearing), pp. 29-52, IRL, Oxford (1987)

Top of page　

[Research] [Members] [Methods] [Publications]

Copyright(C) Department of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Kyoto University. All rights reserved.