TRP channels and more




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  1. Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, Takahashi N, Shirakawa H, Mori Y, Nakagawa T, Kaneko S. Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat. Commun. 7:12840 (2016)
  2. Nagashima T, Shirakawa H, Nakagawa T, Kaneko S: Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism. Sci Rep, 6: 26375 (2016)
  3. So K, Tei Y, Zhao M, Miyake T, Hiyama H, Shirakawa H, Imai S, Mori Y, Nakagawa T, Matsubara K, Kaneko S: Hypoxia-induced sensitization of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice.  Sci Rep, 6: 23261 (2016)
  4. Dogishi K, Kodera M, Oyama S, Shirakawa H, Nakagawa T, Kaneko S: Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide. J Pharmacol Sci, 129: 244-246 (2015)
  5. Miyake T, Shirakawa H, Nakagawa T, Kaneko S: Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration. Glia 63: 1870-1882 (2015)
  6. Nakatuji H, Numata T, Morone N, Kaneko S, Mori Y, Imahori H, Murakami T: Thermosensitive ion channel activation in single neuronal cells by using surface-engineered plasmonic nanoparticles. Angew Chem Int Ed Engl, 54: 11725-11729 (2015)
  7. Miyanohara J, Shirakawa H, Sanpei K, Nakagawa T, Kaneko S: A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice. Biochem Biophys Res Commun, 467: 478-483 (2015)
  8. Imoto Y, Kira T, Sukeno M, Nishitani N, Nagayasu K, Nakagawa T, Kaneko S, Kobayashi K, Segi-Nishida E: Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrus. Mol Brain, 8: 29 (2015)
  9. Asaoka N, Nagayasu K, Nishitani N, Yamashiro M, Shirakawa H, Nakagawa T, Kaneko S: Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT6 receptors in the dorsal raphe nucleus. Neuropharmacology, 95: 261-268 (2015)
  10. Asaoka N, Nagayasu K, Nishitani N, Yamashiro M, Shirakawa H, Nakagawa T, Kaneko S: Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. Neurosci Lett, 593: 72-77 (2015)
  11. Lee EY, Kaneko S, Jutabha P, Zhang X, Seino S, Jomori T, Anzai N, Miki T: Distinct action of the alpha-glucosidase inhibitor miglitol on SGLT3 and GLP1 secretion. J Endocrinol, 224: 205-214 (2015)
  12. So K, Haraguchi K, Asakura K, Isami K, Sakimoto S, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models. J Pharmacol Sci, 127: 237-243 (2015)
  13. Takahashi A, Nagayasu A, Nishitani N, Kaneko S, Koide T: Control of intermale aggression by medial prefrontal cortex activation in the mouse. PLoS One, 9: e94657 (2014)
  14. Nishitani N, Nagayasu K, Asaoka N, Yamashiro M, Shirakawa H, Nakagawa T, Kaneko S: Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex. Int J Neuropsychopharmacol, 17: 1321-1326 (2014)
  15. Zhao M, Nakamura S, Miyake T, So K, Shirakawa H, Tokuyama S, Narita M, Nakagawa T, Kaneko S: Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice. J Pharmacol Sci, 124: 514-517 (2014)
  16. Miyake T, Shirakawa H, Kusano A, Sakimoto S, Konno M, Nakagawa T, Mori Y, Kaneko S: TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia. Biochem Biophys Res Commun, 444: 212-217 (2014)
  17. Sakakiyama M, Maeda S, Isami K, Asakura K, So K, Shirakawa H, Nakagawa T, Kaneko S: Preventive and alleviative effect of tramadol on neuropathic pain in rats: roles of α2-adrenoceptors and spinal astrocytes. J Pharmacol Sci, 124: 244-257 (2014)
  18. Nagayasu K, Kitaichi M, Nishitani N, Asaoka N, Shirakawa H, Nakagawa T, Kaneko S: Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release. Int J Neuropsychopharmacol, 16: 2295-2306 (2013)
  19. Maki K, Kaneko S: Effective concentration-based serum pharmacodynamics for antifungal azoles in a murine model of disseminated Candida albicans infection. Eur J Drug Metab Pharmacokinet: 38: 261-268 (2013)
  20. Isami K, Haraguchi K, So K, Maeda S, Asakura K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model. PLoS One, 8: e66410 (2013)
  21. Munakata M, Shirakawa H, Nagayasu K, Miyanohara J, Miyake T, Nakagawa T, Katsuki H, Kaneko S: The TRPC3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice. Stroke, 44: 1981-1987 (2013)
  22. Homan T, Tsuzuki T, Dogishi K, Shirakawa H, Oyama T, Nakagawa T, Kaneko S: A novel mouse model of chronic inflammatory and overactive bladder by a single intravesical injection of hydrogen peroxide. J Pharmacol Sci, 121: 327-337 (2013)
  23. Nakagawa T, Nagayasu K, Nishitani N, Shirakawa H, Sekiguchi K, Ikarashi Y, Kase Y, Kaneko S. Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α2a-adrenoceptor. Neuroscience, 227: 336-349 (2012)
  24. Zhao M, Isami K, Nakamura S, Shirakawa H, Nakagawa T, Kaneko S: Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol Pain, 8: 55 (2012)
  25. Haraguchi K, Kawamoto A, Isami K, Maeda S, Kusano A, Asakura K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S: TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice. J Neurosci 32: 3931-3941 (2012)
  26. Konno M, Shirakawa H, Iida S, Sakimoto S, Matsutani I, Miyake T, Kageyama K, Nakagawa T, Shibasaki K, Kaneko S: Stimulation of transient receptor potential vanilloid 4(TRPV4) channel suppresses abnormal activation of microglia induced by lipopolysaccharide. Glia 60: 761-770 (2012)
  27. Konno M, Shirakawa H, Miyake T, Sakimoto S, Nakagawa T, Kaneko S: Calumin, a Ca2+-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca2+ release-activated Ca2+ (CRAC) channels. Biochem Biophys Res Commun 417: 784-789 (2012)
  28. Ishida S, Sakamoto Y, Nishio T, Baulac S, Kuwamura M, Ohno Y, Takizawa A, Kaneko S, Serikawa T, Mashimo T: Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures. Brain Res 1435: 154-166 (2012)
  29. Ibi M, Matsuno K, Matsumoto M, Sasaki M, Nakagawa T, Katsuyama M, Iwata K, Zhang J, Kaneko S, Yabe-Nishimura C: Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance. J Neurosci 31: 18094-18103 (2011)
  30. Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, Mori Y: TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol 7: 701-711 (2011)
  31. Nakagawa T, Suzuki Y, Nagayasu K, Kitaichi M, Shirakawa H, Kaneko S: Repeated exposure to methamphetamine, cocaine or morphine induces augmentation of dopamine release in rat mesocorticolimbic slice co-cultures. PLoS One 6: e24865 (2011)
  32. Shirakawa H, Sakimoto S, Nakao K, Sugishita A, Konno M, Iida S, Kusano A, Hashimoto E, Nakagawa T, Kaneko S: TRPC3 Mediates thrombin-induced astrocyte activation and upregulates its own expression in rat cortical astrocytes. J Neurosci 30: 13116-13129 (2010)
  33. Nagayasu K, Yatani Y, Kitaichi M, Kitagawa Y, Shirakawa H, Nakagawa T, Kaneko S. Utility of organotypic raphe slice cultures to investigate the effects of sustained exposure to selective serotonin reuptake inhibitors on serotonin release. Br J Pharmacol 161: 1527-1541 (2010)
  34. Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, FujitaT, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem 285: 35123-35132 (2010)
  35. Nagayasu K, Kitaichi M, Shirakawa H, Nakagawa T, Kaneko S: Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures. J Pharmacol Sci 113: 197-201 (2010)
  36. Deyama S, Takishita A, Tanimoto S, Ide S, Nakagawa T, Satoh M, Minami M: Roles of beta- and alpha2-adrenoceptors within the central nucleus of the amygdala in the visceral pain-induced aversion in rats. J Pharmacol Sci 114: 123-126 (2010)
  37. Deyama S, Katayama T, Kondoh N, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M: Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats. Behav Brain Res 197: 279-283 (2009)
  38. Nishimura K, Unemura K, Tsushima J, Yamauchi Y, Otomo J, Taniguchi T, Kaneko S, Agata K, Kitamura Y: Identification of a novel planarian G-protein-coupled receptor that responds to serotonin in Xenopus laevis oocytes. Biol Pharm Bull 32: 1672-1677 (2009)
  39. Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y: TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med 14: 738-747 (2008)
  40. Maeda S, Kawamoto A, Yatani Y, Shirakawa H, Nakagawa T, Kaneko S: Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats. Mol Pain, 4: 65-78 (2008)
  41. Shirakawa H, Yamaoka T, Sanpei K, Sasaoka H, Nakagawa T, Kaneko S: TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons. Biochem Biophys Res Commun, 377: 1211-1215 (2008)
  42. Nakagawa T, Otsubo Y, Yatani Y, Shirakawa H, Kaneko S: Mechanisms of substrate transport-induced clustering of a glial glutamate transporter GLT-1 in astroglial-neuronal cultures. Eur J Neurosci, 28: 1719-1730 (2008)
  43. Ibi M, Matsuno K, Shiba D, Katsuyama M, Iwara K, Kakehi T, Nakagawa T, Sango K, Shirai Y, Yokoyama T, Kaneko S, Saito N, Yabe-Nishimura, C: Ractive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain. J Neurosci, 28: 9486-9494 (2008)
  44. Deyama S, Katayama T, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M: Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats. J Neurosci, 28: 7728-7736 (2008)
  45. Higuchi M, Suzuki Y, Yatani Y, Kitagawa Y, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S: Augmentation of serotonin release by sustained exposure to 3,4-methylenedioxymethamphetamine and methamphetamine in rat organotypic mesencephalic slice cultures containing raphe serotonergic neurons. J Neurochem, 106: 2410-2420 (2008)
  46. Nakagawa T, Wakamatsu K, Maeda S, Shirakawa H, Kaneko S: Differential contribution of spinal mitogen-activated protein kinases to the phase of long-lasting allodynia evoked by intrathecal administration of ATP in rats. Biol Pharm Bull, 31: 1164-1168 (2008)
  47. Kume T, Kawato Y, Osakada F, Izumi Y, Katsuki H, Nakagawa T, Kaneko S, Niidome T, Takada-Takatori Y, Akaike A: Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype. Neurosci Lett, 443: 199-203 (2008)
  48. Nakao K, Shirakawa H, Sugishita A, Matsutani I, Niidome T, Nakagawa N, Kaneko S: Ca2+ mobilization mediated by transient receptor potential canonical 3 is associated with thrombin-induced morphological changes of 1321N1 human astrocytoma cells. J Neurosci Res, 86: 2722-2732 (2008)
  49. Yamauchi Y, Izumi T, Unemura K, Uenishi Y, Nakagawa T, Kaneko S: Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethanphetamine (MDMA) under acidic conditions. Neurosci Lett, 428: 72-76 (2007)
  50. Tanaka K, Shirakawa H, Okada K, Konno M, Nakagawa T, Serikawa T, Kaneko S: Increased Ca2+ channel currents in cerebellar Purkinje cells of the ataxic groggy rat. Neurosci Lett, 426: 75-80 (2007)
  51. Deyama S, Yamamoto J, Machida T, Tanimoto S, Nakagawa T, Kaneko S, Satoh M, Minami M: Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces pain-induced aversion. Neurosci Res, 59: 199-204 (2007)
  52. Nakagawa T, Wakamatsu K, Zhang N, Maeda S, Minami M, Satoh M, Kaneko S: Intrathecal administration of ATP produces long-lasting allodynia in rats: differential mechanisms in the phase of the induction and maintenance. Neuroscience, 147: 445-455 (2007)
  53. Deyama S, Nakagawa T, Kaneko S, Uehara T, Minami M: Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats. Behav Brain Res, 176: 367-371 (2007)
  54. Shimamoto K, Otsubo Y, Shigeri Y, Yasuda-Kamatani Y, Satoh M, Kaneko S, Nakagawa T: Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol, 71: 294-302 (2007)
  55. Tokuda S, Kuramoto T, Tanaka K, Kaneko S, Takeuchi IK, Sasa M, Serikawa T: The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures. Brain Res, 1133: 168-177 (2007)
  56. Kume T, Taguchi R, Katsuki H, Akao M, Sugimoto H, Kaneko S, Akaike A. Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation. Eur J Pharmacol, 542: 69-76 (2006)
  57. Fukui M, Nakagawa T, Minami M, Satoh M, Kaneko S. Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats. Mol Pain, 2: 19 (2006)
  58. Kaneko S, Kawakami S, Hara Y, Wakamori M, Itoh E, Minami T, Takada Y, Kume K, Katsuki H, Mori Y, Akaike A. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci, 101: 66-76 (2006)
  59. Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A: Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons. Br J Pharmacol, 147: 729-736 (2006)
  60. Yazaki K, Yamanaka N, Masuno T, Konagai S, Shitan N, Kaneko S, Ueda K, Sato F: Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation. Plant Mol Biol, 61: 491-503 (2006)
  61. Kinoshita-Kawada M, Tang J, Xial R, Kaneko S, Foskett JK, Zhu MX: Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch Eur J Physiol 450: 345-354 (2005)
  62. Fujio M, Nakagawa T, Suzuki Y, Satoh M, Kaneko S: Facilitative effect of a glutamate transporter inhibitor (2S,3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate on the expression of methamphetamine-induced behavioral sensitization in rats. J Pharmacol Sci, 99: 415-418 (2005)
  63. Fujio M, Nakagawa T, Sekiya Y, Ozawa T, Suzuki Y, Minami M, Satoh M, Kaneko S: Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats. Eur J Neurosci, 22: 2744-2754 (2005)
  64. Nakagawa T, Yamamoto R, Fujio M, Suzuki S, Minami M, Satoh M, Kaneko S: Involvement of the bed nucleus of the stria terminalis activated by the central nucleus of the amygdala in the negative affective component of morphine withdrawal in rats. Neuroscience, 134: 9-19 (2005)
  65. Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A: Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons. Eur J Neurosci, 21: 2329-2335 (2005)
  66. Toyohara H, Yamamoto S, Hosoi M, Takagi M, Hayashi I, Nakao K, Kaneko S: Scallop DMT functions as a Ca2+ transporter. FEBS Lett, 579: 2727-2730 (2005)
  67. Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A: alpha-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology, 47: 904-915 (2004)
  68. Fujimoto S, Katsuki H, Kume T, Kaneko S, Akaike A: Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures. Neurosci Res, 50: 179-187 (2004)