Research at the Laboratory of Molecular Metabology

Publications
2019
2018
2017
2015
2014
2013
2012
2011
2010
2009
2008
2007
2005
Presentations

Rhythm on a chip: circadian entrainment in vitro is the next frontier in body-on-a chip technology
Jean-Michel Fustin，Meina Li, Bryan Gao, Qianyu Chen, Tianhong Cheng, Alastair G. Stewart.
[Current Opinion in Pharmacology] 2019/10/08 48:127–136

Non-coding cis-regulatory element E′-box of Period2 is essential for daily maintenance of organismal behavior and physiology.
Masao Doi, Hiroyuki Shimatani, Yuta Atobe, Iori Murai, Hida Hayashi, Yukari Takahashi, Jean-Michel Fustin，Yoshiaki Yamaguchi, Hiroshi Kiyonari, Nobuya Koike, Kazuhiro Yagita, Choogon Lee, Manabu Abe, Kenji Sakimura, Okamura Hitoshi.
[Nat Commun.] 2019/06/12; 10(1):2563. doi: 10.1038/s41467-019-10532-2.

The methyl cycle is a conserved regulator of biological clocks
Fustin Jean-Michel，Shiqi Ye, Christin Rakers, Marijke Versteven, Samantha J. Cargill, T. Katherine Tamai, Yao Xu, Maria Luísa Jabbur, Rika Kojima, Melisa L. Lamberti, Kumiko Yoshioka-Kobayashi, David Whitmore, Ryoichiro Kageyama, Takuya Matsuo, Ralf Stanewsky, Diego A. Golombek, Carl Hirschie Johnson, Gerben van Ooijen, Hitoshi Okamura.
[bioRxiv] 2019/06/29. doi: 10.1101/653667

CK1δの2つのアイソフォームによる体内リズムの拮抗的速度調節機構
Fustin Jean-Michel，岡村均.
[医学のあゆみ.] 2019年07月号 Vol.270 No.3

RNAメチル化
Fustin Jean-Michel，岡村均.
[生体の科学.] 2018年10月号 Vol.69 No.5

RNAのメチル化による概日リズム制御
Fustin Jean-Michel，柏﨑安男.
[実験医学.] 2018年12月号 Vol.36 No.19

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.
Narasimamurthy R, Hunt SR, Lu Y, Fustin JM, Okamura H, Partch CL, Forger DB, Kim JK, Virshup DM.
[Proc Natl Acad Sci U S A.]2018 Jun 5;115(23):5986-5991. doi: 10.1073/pnas.1721076115.

Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock.
Fustin JM, Kojima R, Itoh K, Chang HY, Ye S, Zhuang B, Oji A, Gibo S, Narasimamurthy R, Virshup D, Kurosawa G, Doi M, Manabe I, Ishihama Y, Ikawa M, Okamura H.
[Proc Natl Acad Sci U S A.]2018 Jun 5;115(23):5980-5985. doi: 10.1073/pnas.1721371115.

Circadian rhythms of micturition during jet lag.
Itoh K, Yasuda M, Maeda Y, Fustin JM, Yamaguchi Y, Kono Y, Negoro H, Kanematsu A, Ogawa O, Doi M, Okamura H.
[Biomed Res. ]2018;39(2):57-63. doi: 10.2220/biomedres.39.57.

Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.
Chao HW, Doi M, Fustin JM, Chen H, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N, Yamaguchi Y, Yasunaga JI, Matsuoka M, Sakai M, Matsumoto M, Hamada S, Okamura H.
[Nat Commun. ]2017 Dec 21;8(1):2238. doi: 10.1038/s41467-017-02207-7.

Circadian Profiling of Amino Acids in the SCN and Cerebral Cortex by Laser Capture Microdissection-Mass Spectrometry.
Fustin JM, Karakawa S, Okamura H.
[J Biol Rhythms. ]2017 Dec;32(6):609-620. doi: 10.1177/0748730417735922.

Carbachol Induces Phase-dependent Phase Shifts of Per1 Transcription Rhythms in Cultured Suprachiasmatic Nucleus Slices.
Dojo K, Yamaguchi Y, Fustin JM, Doi M, Kobayashi M, Okamura H.
[J Biol Rhythms. ]2017 Apr;32(2):101-108. doi: 10.1177/0748730417691205.

Hypertension Caused by Disruption of the Circadian System.
Hitoshi Okamura, Miho Yasuda, Jean-Michel Fustin, Masao Doi
[Circadian Medicine ]135 May 2015
Editor: Christopher S. Colwell

Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism.
Doi M, Satoh F, Maekawa T, Nakamura Y, Fustin JM, Tainaka M, Hotta Y, Takahashi Y, Morimoto R, Takase K, Ito S, Sasano H, Okamura H.
[J Clin Endocrinol Metab. ]2014 Feb;99(2):E257-62. doi: 10.1210/jc.2013-3279.

生体リズムの周期はメッセンジャーRNAのメチル化で変動する.
Jean-Michel Fustin, 岡村均
[医学のあゆみ ]2014 251(2): 179 -180

RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H.
[Cell ]2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.

Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag.
Yamaguchi Y, Suzuki T, Mizoro Y, Kori H, Okada K, Chen Y, Fustin JM, Yamazaki F, Mizuguchi N, Zhang J, Dong X, Tsujimoto G, Okuno Y, Doi M, Okamura H.
[Science ]2013 Oct 4;342(6154):85-90. doi: 10.1126/science.1238599.

Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse.
Maywood ES, Drynan L, Chesham JE, Edwards MD, Dardente H, Fustin JM, Hazlerigg DG, O'Neill JS, Codner GF, Smyllie NJ, Brancaccio M, Hastings MH.
[Proc Natl Acad Sci U S A. ]2013 Jun 4;110(23):9547-52. doi: 10.1073/pnas.1220894110.

Rhythmic nucleotide synthesis in the liver: temporal segregation of metabolites.
Fustin JM, Doi M, Yamada H, Komatsu R, Shimba S, Okamura H.
[Cell Rep. ]2012 Apr 19;1(4):341-9. doi: 10.1016/j.celrep.2012.03.001.

Circadian clock signals in the adrenal cortex.
Ota T, Fustin JM, Yamada H, Doi M, Okamura H.
[Mol Cell Endocrinol. ]2012 Feb 5;349(1):30-7. doi: 10.1016/j.mce.2011.08.010.

Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus.
Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K, Yamaguchi Y, Matsuo M, Fustin JM, Tanaka R, Santo Y, Yamada H, Takahashi Y, Araki M, Nakao K, Aizawa S, Kobayashi M, Obrietan K, Tsujimoto G, Okamura H.
[Nat Commun. ]2011;2:327. doi: 10.1038/ncomms1316.

Accurate determination of S-phase fraction in proliferative cells by dual fluorescence and peroxidase immunohistochemistry with 5-bromo-2'-deoxyuridine (BrdU) and Ki67 antibodies.
Tanaka R, Tainaka M, Ota T, Mizuguchi N, Kato H, Urabe S, Chen Y, Fustin JM, Yamaguchi Y, Doi M, Hamada S, Okamura H.
[J Histochem Cytochem. ]2011 Aug;59(8):791-8. doi: 10.1369/0022155411411090.

Transportin 1 in the mouse brain: appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock.
Sato M, Mizoro Y, Atobe Y, Fujimoto Y, Yamaguchi Y, Fustin JM, Doi M, Okamura H.
[J Comp Neurol. ]2011 Jun 15;519(9):1770-80. doi: 10.1002/cne.22600.

Hypertension due to loss of clock: novel insight from the molecular analysis of Cry1/Cry2-deleted mice.
Okamura H, Doi M, Yamaguchi Y, Fustin JM.
[Curr Hypertens Rep. ]2011 Apr;13(2):103-8. doi: 10.1007/s11906-011-0181-3.

Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences.
Okamura H, Doi M, Fustin JM, Yamaguchi Y, Matsuo M.
[Adv Drug Deliv Rev. ]2010 Jul 31;62(9-10):876-84. doi: 10.1016/j.addr.2010.06.004.

Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.
Mizoro Y, Yamaguchi Y, Kitazawa R, Yamada H, Matsuo M, Fustin JM, Doi M, Okamura H.
[PLoS One. ]2010 Jun 3;5(6):e10951. doi: 10.1371/journal.pone.0010951.

Circadian expression of the Na+/H+ exchanger NHE3 in the mouse renal medulla.
Nishinaga H, Komatsu R, Doi M, Fustin JM, Yamada H, Okura R, Yamaguchi Y, Matsuo M, Emoto N, Okamura H.
[Biomed Res. ]2009 Apr;30(2):87-93.

Transcriptional feedback loops in the ovine circadian clock.
Dardente H, Fustin JM, Hazlerigg DG.
[Comp Biochem Physiol A Mol Integr Physiol. ]2009 Aug;153(4):391-8. doi: 10.1016/j.cbpa.2009.03.016.

Cry1 circadian phase in vitro: wrapped up with an E-box.
Fustin JM, O'Neill JS, Hastings MH, Hazlerigg DG, Dardente H.
[J Biol Rhythms. ]2009 Feb;24(1):16-24. doi: 10.1177/0748730408329267.

Egr1 involvement in evening gene regulation by melatonin.
Fustin JM, Dardente H, Wagner GC, Carter DA, Johnston JD, Lincoln GA, Hazlerigg DG.
[FASEB J. ] 2009 Mar;23(3):764-73. doi: 10.1096/fj.08-121467.

Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals.
Dardente H, Mendoza J, Fustin JM, Challet E, Hazlerigg DG.
[PLoS One. ] 2008;3(10):e3530. doi: 10.1371/journal.pone.0003530.

Ancestral TSH mechanism signals summer in a photoperiodic mammal.
Hanon EA, Lincoln GA, Fustin JM, Dardente H, Masson-Pévet M, Morgan PJ, Hazlerigg DG.
[Curr Biol. ] 2008 Aug 5;18(15):1147-52. doi: 10.1016/j.cub.2008.06.076.

Quantitative trait Loci for regional adiposity in mouse lines divergently selected for food intake.
Rance KA, Hambly C, Dalgleish G, Fustin JM, Bünger L, Speakman JR.
[Obesity (Silver Spring). ] 2007 Dec;15(12):2994-3004. doi: 10.1038/oby.2007.357.

A paternally imprinted QTL for mature body mass on mouse chromosome 8.
Rance KA, Fustin JM, Dalgleish G, Hambly C, Bünger L, Speakman JR.
[Mamm Genome. ] 2005 Aug;16(8):567-77. Epub 2005 Sep 14.

Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet.
Hambly C, Adams A, Fustin JM, Rance KA, Bünger L, Speakman JR.
[Obes Res. ] 2005 Mar;13(3):556-66.