新着情報

共同研究における研究成果発表 (2007. 3)

 以下にリストされた国内外研究グループとの最近の共同研究成果の中でも、当研究室にて発見されたジャンクトフィリンの研究にて、その遺伝子変異とヒト肥大型心筋症の発症が連関することが東京女子医大グループとの共同研究にて見出されたのは、臨床医学的にも注目される成果です(論文7)。

1. Chugun, A., Sato, O., Takeshima, H. & Ogawa, Y. Mg2+ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca2+ concentrations. Am. J. Cell Physiol. 292, C535-544, 2007.
2. Miyakawa, K., Uchida, A., Shiraki, T., Teshima, K., Takeshima, H. & Shibata, S. ORL1 receptor-mediated down-regulation of mRER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle. Neuropharmacol. 52, 1055-1064, 2007.

3. Nagai, J., Kurokawa, M., Takeshima, H., Kieffer, B. L. & Ueda, H. Nociceptin receptor (NOP)-deficient mice show memory and learning enhancement in a novel KUROBOX apparatus using stress-free positive cue task. J. Pharmacol. Exp. Ther. 321, 195-201, 2007.

4. Phimister, A. J., Lango, J., Lee, E. H., Ernst-Russell, M., Takeshima, H., Ma, J., Allen, P. D. & Pessah, I. N. Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. J. Biol. Chem. 282, 8667-8677, 2007.

5. Weisleder, N., Ferrante, C., Hirata, Y., Collet, C., Chu, Y., Cheng, H., Takeshima, H. & Ma, J. Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle. Cell Calcium in press.

6. Hotta, S., Morimura, K., Ohya, S., Muraki, K., Takeshima, H. & Imaizumi, Y. Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle. J. Physiol. in press.

7. Matsushita, Y., Furukawa, T., Kasanuki, H., Nishibatake, M., Kurihara, Y., Ikeda, A., Kamatani, N., Takeshima, H. & Matsuoka, R. Mutations of junctophilin type 2 associated with hypertrophic cardiomyopathy. J. Hum. Genet. 52, 543-548, 2007.

 
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