高倉喜信

English

E-mail: takakura@pharm.kyoto-u.ac.jp

1999

• Gene expression and antitumor effects following direct interferon (IFN)-g gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice
  Nomura T., Yasuda K., Yamada T., Okamoto S., Mahato RI., Watanabe Y., Takakura Y. and Hashida M.
  Gene Ther. 6(1), 121-129 (1999) Abstract (PubMed)
• Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats
  Ogawara K., Yoshida M., Furumoto K., Takakura Y., Hashida M., Higaki K. and Kimura T.
  J. Drug Targeting 7(3), 213-221 (1999) Abstract (PubMed)
• Interaction of polystyrene microspheres with liver cells: Roles of membrane receptors and serum proteins
  Ogawara K., Yoshida M., Takakura Y., Hashida M., Higaki K. and Kimura T.
  Biochim. Biophys. Acta 1472(1-2), 165-172 (1999) Abstract (PubMed)
• Design of polymeric prodrugs of prostaglandin E1 having galactose residue for hepatocyte targeting
  Hashida M., Akamatsu K., Nishikawa M., Yamashita F. and Takakura Y.
  J. Controlled Release 62(1-2), 253-262 (1999) Abstract (PubMed)
• Mechanisms of hepatic disposition of polystyrene microspheres in rats: Effects of serum depend on the sizes of microspheres
  Ogawara K., Yoshida M., Kubo J., Nishikawa M., Takakura Y., Hashida M., Higaki K. and Kimura T.
  J. Controlled Release 61(3), 241-250 (1999) Abstract (PubMed)
• Development of a hepatocyte-specific prostaglandin E1 polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice
  Akamatsu K., Yamasaki Y., Nishikawa M., Takakura Y. and Hashida M.
  J. Pharmacol. Exp. Ther. 290(3), 1242-1249 (1999) Abstract (PubMed)
• Disposition of radioactivity after injection of liver-targeted proteins labeled with 111In or 125I ; effect of labeling on distribution and excretion of radioactibity in rats
  Staud F., Nishikawa M., Takakura Y. and Hashida M.
  J. Pharm. Sci. 88(6), 577-585 (1999) Abstract (PubMed)
• Targeted delivery and improved therapeutic potential of catalase by chemical modification: combination with superoxide dismutase derivatives
  Yabe Y., Nishikawa M., Tamada A., Takakura Y. and Hashida M.
  J. Pharmacol. Exp. Ther. 289(2), 1176-1184 (1999) Abstract (PubMed)
• Hepatic uptake of polystyrene microspheres in rats: effect of particle size on intrahepatic distribution
  Ogawara K., Yoshida M., Higaki K., Kimura T., Shiraishi K., Nishikawa M., Takakura Y. and Hashida M.
  J. Controlled Release 59, 15-22 (1999) Abstract (PubMed)
• Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation
  Staud F., Nishikawa M., Takakura Y. and Hashida M.
  Biochim. Biophys. Acta 1427(2), 183-192 (1999) Abstract (PubMed)
• Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: quantitative comparison with other hepatotropic ligands
  Ogawara K., Hasegawa S., Nishikawa M., Takakura Y. and Hashida M.
  J. Drug Targeting 6(5), 349-360 (1999) Abstract (PubMed)
• Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion inju-ry in mice
  Yabe Y., Koyama Y., Nishikawa M., Takakura Y. and Hashida M.
  Free Radic. Res. 30, 265-274 (1999) Abstract (PubMed)
• Pharmacokinetics and disposition characteristics of recombinant decorin after intravenous injection into mice
  Masuda H., Takakura Y. and Hashida M.
  Biochim. Biophys. Acta 1426, 420-428 (1999) Abstract (PubMed)
• Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice
  Nishikawa M., Staud F., Takemura S., Takakura Y. and Hashida M.
  Biol. Pharm. Bull. 22(2), 214-218 (1999) Abstract (PubMed)
• Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice
  Takakura Y., Takagi T., Hashiguchi M., Nishikawa M., Yamashita F., Doi T., Imanishi T., Suzuki H., Kodama T. and Hashida M.
  Pharm. Res. 16(4), 503-508 (1999) Abstract (PubMed)
• Stimulation side-dependent asymmetrical secretion of poly I :poly C-induced interferon-b from polarized epithelial cell lines
  Okamoto S., Nakanishi K., Watanabe Y., Yamashita F., Takakura Y. and Hashida M.
  Biochem. Biophys. Res. Commun. 254, 5-9 (1999) Abstract (PubMed)
• Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate
  Yura H., Yoshimura N., Hamashima T., Akamatsu K., Nishikawa M., Takakura Y. and Hashida M.
  J. Controlled Release 57(1), 87-99 (1999) Abstract (PubMed)

1998

• Disposition characteristics of glycosylated poly(amino acids) as liver cell-specific drug carrier
  Akamatsu K., Imai M., Yamasaki Y., Nishikawa M., Takakura Y. and Hashida M.
  J. Drug Targeting 6(3), 229-239 (1998) Abstract (PubMed)
• Hepatic disposition characteristics of recombinant human interleukin-11(rhIL-11) in the perfused rat liver
  Takagi A., Yabe Y., Yoshida M., Takakura Y. and Hashida M.
  Biol. Pharm. Bull. 21(12), 1364-1366 (1998) Abstract (PubMed)
• 薬物経皮吸収に及ぼす代謝の影響−代謝過程を考慮した皮膚拡散モデルに基づく解析
  Lim Chee Wooi, 山下富義，高倉喜信，橋田　充
  Drug Delivery System 13(6), 423-428 (1998)
• Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes
  Kawakami S., Yamashita F., Nishikawa M., Takakura Y. and Hashida M.
  Biochem. Biophys. Res. Commun. 252(1), 78-83 (1998) Abstract (PubMed)
• Development of a macromolecular prodrug of FK 506: I. Synthesis of FK 506-dextran conjugate
  Yura H., Yoshimura N., Hamashima T., Oka T., Takakura Y. and Hashida M.
  Transplant. Proc. 30, 3598-3599 (1998) Abstract (PubMed)
• Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506-dextran conjugate
  Yura H., Yoshimura N., Hamashima T., Oka T., Takakura Y. and Hashida M.
  Transplant. Proc. 30, 1031-1032 (1998) Abstract (PubMed)
• Development of a macromolecular prodrug of FK 506: III: In vivo disposition of FK 506-dextran conjugate
  Yoshimura N., Yura H., Hamashima T., Oka T., Takakura Y. and Hashida M.
  Transplant. Proc. 30, 1029-1030 (1998) Abstract (PubMed)
• Cationic liposome-mediated efficient induction of type I interferons by a low dose of poly I: poly C in mouse cell lines
  Okamoto S., Watanabe Y., Takakura Y. and Hashida M.
  J. Biochem. 124(4), 697-701 (1998) Abstract (PubMed)
• Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties
  Nishikawa M., Takemura S., Takakura Y. and Hashida M.
  J. Pharmacol. Exp. Ther. 287(1), 408-415 (1998) Abstract (PubMed)
• Biological effects and cellular uptake of c-myc antisense oligonucleotides and their cationic liposome complexes
  Kanamaru T., Takagi T., Takakura Y. and Hashida M.
  J. Drug Targeting 5(4), 235-246 (1998) Abstract (PubMed)
• Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine)
  Hashida M., Takemura S., Nishikawa M. and Takakura Y.
  J. Controlled Release 53(1/3), 301-310 (1998) Abstract (PubMed)
• Control of plasma cholesterol-lowering action of probucol with various lipid carrier systems
  Takino T., Koreeda N., Nomura T., Sakaeda T.(ne Kakutani), Yamashita F., Takakura Y. and Hashida M.
  Biol. Pharm. Bull. 21(5), 492-497 (1998) Abstract (PubMed)
• Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages
  Takagi T., Hashiguchi M., Mahato RI., Tokuda H., Takakura Y. and Hashida M.
  Biochem. Biophys. Res. Commun. 245, 729-733 (1998) Abstract (PubMed)
• Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells
  Nakamura M., Davila-Zavala P., Tokuda H., Takakura Y. and Hashida M.
  Biochem. Biophys. Res. Commun. 245, 235-239 (1998) Abstract (PubMed)
• Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection
  Nomura T., Saikawa A., Morita S., Sakaeda T.(ne Kakutani), Yamashita F., Honda K., Takakura Y. and Hashida M.
  J. Controlled Release 52(3), 239-252 (1998) Abstract (PubMed)
• Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors
  Nomura T., Koreeda N., Yamashita F., Takakura Y. and Hashida M.
  Pharm. Res. 15(1), 128-132 (1998) Abstract (PubMed)
• Cellular uptake properties of oligonucleotides in LLC-PK1 renal epithelial cells
  Takakura Y., Oka Y. and Hashida M.
  Antisense Nucl. Acid Drug Develop. 8, 67-73 (1998) Abstract (PubMed)
• Pharmacokinetic analysis of hepatic uptake of galactosylated bovine serum albumin in perfused rat liver
  Ogawara K., Nishikawa M., Takakura Y. and Hashida M.
  J. Controlled Release 50(1/3), 309-317 (1998) Abstract (PubMed)

1997

• 皮膚拡散モデルに基づく皮膚中薬物濃度勾配の評価
  瀬古則貴，坂東博人，山下富義，高倉喜信，橋田　充
  Drug Delivery System, 12(5), 359-365 (1997)
• Synthesis and biodistribution study of liver-specific prostaglandin E1 polymeric conjugate
  Akamatsu K., Nishikawa M., Takakura Y. and Hashida M.
  Int. J. Pharm. 155(1), 65-74 (1997)
• Effects of skin metabolism on percutaneous penetration of lipophilic drugs
  Bando H., Mohri S., Yamashita F., Takakura Y. and Hashida M.
  J. Pharm. Sci. 86(6), 759-761 (1997) Abstract (PubMed)
• Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer
  Nomura T., Nakajima S., Kawabata K., Yamashita F., Takakura Y. and Hashida M.
  Cancer Res. 57, 2681-2686 (1997) Abstract (PubMed)
• Uptake characteristics of anionized and cationized proteins in brain microvessel endothelial cells
  Tokuda H., Nagano H., Takakura Y. and Hashida M.
  Pharm. Sci. 3(3), 147-151 (1997)
• Pharmacokinetic analysis of scavenger receptor-mediated uptake of anionized proteins in the isolated perfused rat liver
  Furitsu H., Ogawara K., Fujita T., Yamashita F., Takakura Y., Sezaki H. and Hashida M.
  Int. J. Pharm. 151, 15-26 (1997)
• Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by direct cationization
  Takagi T., Kitano M., Masuda S., Tokuda H., Takakura Y. and Hashida M.
  Biochim. Biophys. Acta 1335(1-2), 91-98 (1997) Abstract (PubMed)
• Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis
  Hashida M., Hirabayashi H., Nishikawa M. and Takakura Y.
  J. Controlled Release 46(1,2), 129-137 (1997)
• Non-polarized secretion of mouse interferon-b from gene-transferred human intestinal caco-2 cells
  Kawabata K., Kondo M., Watanabe Y., Takakura Y. and Hashida M.
  Pharm. Res. 14(4), 483-485 (1997) Abstract (PubMed)
• A physiological role of interferon (IFN)-b derived from tumor: tumor growth of a mouse bladder carcinoma line MBT-2 is partially suppressed by autocrine IFN-b
  Kawabata K., Okamoto S., Takakura Y., Hashida M., Hashimura T. and Watanabe Y.
  Cancer Lett. 113, 159-164 (1997) Abstract (PubMed)
• Renal disposition of recombinant human interleukin-11 in the isolated perfused rat kidney
  Takagi A., Yabe Y., Oka Y., Sawai K., Takakura Y. and Hashida M.
  Pharm. Res. 14(1), 86-90 (1997) Abstract (PubMed)
• In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model
  Bando H., Sahashi M., Yamashita F., Takakura Y. and Hashida M.
  Pharm. Res. 14(1), 56-62 (1997) Abstract (PubMed)
• Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine)
  Mahato RI., Takemura S., Akamatsu K., Nishikawa M., Takakura Y. and Hashida M.
  Biochem. Pharmacol. 53(6), 887-895 (1997) Abstract (PubMed)

1996

• Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system
  Takakura Y., Mahato RI., Yoshida M., Kanamaru T. and Hashida M.
  Antisense Nucl. Acid Drug Develop. 6, 177-183 (1996) Abstract (PubMed)
• In vivo skin penetration enhancement of acyclovir by theoretical design of prodrug-enhancer combination
  Bando H., Sahashi M., Mohri S., Yamashita F., Takakura Y. and Hashida M.
  Int. J. Pharm. 145, 103-113 (1996)
• Pharmacokinetics and targeted delivery of proteins and genes
  Hashida M., Mahato RI., Kawabata K., Miyao T., Nishikawa M. and Takakura Y.
  J. Controlled Release 41, 91-97 (1996)
• Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats
  Jani PU., Nomura T., Yamashita F., Takakura Y., Florence AT. and Hashida M.
  J. Drug Targeting 4, 87-93 (1996) Abstract (pubMed)
• Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system
  Saikawa A., Nomura T., Yamashita F., Takakura Y., Sezaki H. and Hashida M.
  Pharm. Res. 13(10), 1438-1444 (1996) Abstract (PubMed)
• Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake
  Sawai K., Mahato RI., Oka Y., Takakura Y. and Hashida M.
  J. Pharmacol. Exp. Ther. 279(1), 284-290 (1996) Abstract (PubMed)
• Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a biodegradable carrier for liver-specific drug delivery
  Hirabayashi H., Nishikawa M., Takakura Y. and Hashida M.
  Pharm. Res. 13(6), 880-884 (1996) Abstract (PubMed)
• Analysis of in vitro skin penetration of acyclovir prodrugs based on a diffusion model with a metabolic process
  Bando H., Sahashi M., Takagi T., Yamashita F., Takakura Y. and Hashida M.
  Int. J. Pharm. 135(1,2), 91-102 (1996)
• Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system
  Yoshida M., Mahato RI., Kawabata K., Takakura Y. and Hashida M.
  Pharm. Res. 13(4), 599-603 (1996) Abstract (PubMed)
• Theoretical design of prodrug-enhancer combination based on a skin diffusion model: Prediction of permeation of acyclovir prodrugs treated with 1-geranylazacycloheptan-2-one
  Bando H., Takagi T., Yamashita F., Takakura Y. and Hashida M.
  Pharm. Res. 13(3), 427-432 (1996) Abstract (PubMed)

2000 年以後の論文はこちら