高倉喜信

English

E-mail: takakura@pharm.kyoto-u.ac.jp

昭和 32 年 6 月 30 日生

略歴

昭和 56 年 3 月　京都大学薬学部薬学科卒業
昭和 58 年 3 月　同大学院修士課程修了
昭和 59 年 2 月　京都大学薬学部助手（薬剤学講座）
昭和 62 年 5 月　京都大学薬学博士取得
平成元年 4 月　アメリカ合衆国カンサス大学研究員（ Ronald T. Borchardt 教授）
平成 4 年 4 月　京都大学薬学部助教授（薬剤学講座）
平成 9 年 5 月　京都大学大学院薬学研究科教授（病態情報薬学分野）

学術誌：
Executive Editor: Advanced Drug Delivery Reviewer (2006-)
Editorial Board: European Journal of Pharmaceutical Sciences (2002-)
Editorial Board: Drug Metabolism and Pharmacokinetics (2002-)
Editorial Advisory Board: Pharmaceutical Research (2001-)
Editorial Advisory Board: Journal of Biochemistry (2000-)
Editorial Board: Biological and Pharmaceutical Bulletin (1999-2003)

受賞：
日本薬物動態学会奨励賞（平成 7 年 11 月）
日本薬学会奨励賞（平成 8 年 3 月）

【原著論文】 (1996-2009)

2009

• Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors
  Yuki Takahashi, Kiyoshi Yamaoka, Makiya Nishikawa, Yoshinobu Takakura
  J Pharm Sci. 2009 Jan;98(1):74-80. Abstract (PubMed)

• Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation
  Seiji Takemoto, Makiya Nishikawa, Takayuki Otsuki, Ayumi Yamaoka, Kazuki Maeda, Atsushi Ota, Yoshinobu Takakura
  J Control Release. in press (2008)
• Reactivation of Silenced Transgene Expression in Mouse Liver by Rapid, Large-volume Injection of Isotonic Solution
  Makiya Nishikawa, Ayumi Nakayama, Yuki Takahashi, Yasushi Fukuhara and Yoshinobu Takakura
  Hum Gene Ther. 2008 Aug 11. [Epub ahead of print] Abstract (PubMed)
• Gene silencing of β-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice
  Yuki Takahashi, Makiya Nishikawa, Tetsuya Suehara, Naomi Takiguchi and Yoshinobu Takakura
  Int J Cancer. 2008 Nov 15;123(10):2315-20 Abstract (PubMed)
• Unique Cytokine Production Profile following Stimulation with DNA in Macrophages from NZB/W F1 Mice
  Yoshiyuki Ogawa, Takaharu Yoshinaga, Makiya Nishikawa, Yoshinobu Takakura
  Biol Pharm Bull. 2008 Jun;31(6):1244-9 Abstract (PubMed)
• Enhancement of anti-proliferative activity of interferons by RNAi-mediated silencing of SOCS gene expression in tumor cells
  Yuki Takahashi, Haruka Kaneda, Nana Takasuka, Kayoko Hattori, Makiya Nishikawa, Yoshinobu Takakura
  Cancer Sci. 2008 Aug;99(8):1650-5. Abstract (PubMed)
• Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1α expression in tumor cells and hepatocytes
  Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura
  Gene Ther. 2008 Apr;15(8):572-82. Abstract (PubMed)
• Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation
  Makiya Nishikawa, Mitsuhiro Matono, Sakulrat Rattanakiat, Nao Matsuoka and Yoshinobu Takakura
  Immunology. 2008 Jun;124(2):247-55. Abstract (PubMed)
• Cellular activation by plasmid DNA in various macrophages in primary culture
  Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno and Yoshinobu Takakura
  J Pharm Sci. 2008 Oct;97(10):4575-85. Abstract (PubMed)
• Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice
  Keiko Kako, Hiroyuki Yoshida, Makiya Nishikawa, and Yoshinobu Takakura
  J Pharm Sci. 2008 Aug;97(8):3074-83. Abstract (PubMed)

• Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL11) by chemical modification with polyethylene glycol
  Takagi A., Yamashita N., Yoshioka T., Takaishi Y., Sano K., Yamagichi H., Maeda A., Saito K. Takakura Y. and Hashida M.
  J Control Release. 2007 Jun 22;119(3):271-8. Abstract (PubMed)
• Action mechanism of tachyplesin I and effects of PEGylation
  Imura Y., Nishida M., Ogawa Y., Takakura Y. and Matsuzaki K.
  Biochim Biophys Acta. 2007 May;1768 (5):1160-9. Abstract (PubMed)
• Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA
  Kawano H., Nishikawa M., Mitsui M., Takahashi Y., Hattori K., Yamaoka K., Watanabe Y. and Takakura Y.
  Int J Cancer. 2007 Jul 15;121 (2):401-6. Abstract (PubMed)
• Design of PCR-amplified DNA fragments for in vivo gene delivery: Size-dependency on stability and transgene expression
  Hirata K., Nishikawa M., Kobayashi N., Takahashi Y. and Takakura Y.
  J Pharm Sci. 2007 Mar 23; in press. Abstract (PubMed)
• Induction of antigen-specific cytotoxic T lymphocytes by immunization with negatively charged soluble antigen through scavenger receptor-mediated delivery
  Yamasaki Y., Ikenaga T., Ohtsuki T., Nishikawa M. and Takakura Y.
  Vaccine. 2007 Jan 2;25 (1):85-91. Abstract (PubMed)
• Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor
  Nagayama S., Ogawara K., Minato K., Fukuoka Y., Takakura Y., Hashida M., Higaki K. and Kimura T.
  Int J Pharm. 2007 Feb 1;329 (1-2):192-8. Abstract (PubMed)
• Plasmid DNA uptake and subsequent cellular activation characteristics in human monocyte-derived cells in primary culture
  Fukuhara Y., Naoi T., Ogawa Y., Nishikawa M. and Takakura Y.
  J Pharm Sci. 2007 Jun;96 (6):1576-84. Abstract (PubMed)
• DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells
  Yoshinaga T., Yasuda K., Ogawa Y., Nishikawa M. and Takakura Y.
  Immunology. 2007 Mar;120 (3):295-302. Abstract (PubMed)

• Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha
  Takahashi Y., Nishikawa M. and Takakura Y.
  J Control Release. 2006 Nov;116 (1):90-5. Abstract (PubMed)
• Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL11)
  Takagi A., Yamashita N., Yoshioka T., Takaishi Y., Nakanishi K., Takemura S., Maeda A., Saito K., Takakura Y. and Hashida M.
  J Control Release. 2006 Oct 10;115 (2):134-9. Abstract (PubMed)
• Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice
  Kawase A., Isaji K., Yamaoka A., Kobayashi N., Nishikawa M. and Takakura Y.
  Vaccine. 2006 Jul 7;24 (27-28):5535-45. Abstract (PubMed)
• Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments
  Takemoto S., Yamaoka K., Nishikawa M. and Takakura Y.
  Drug Metab Pharmacokinet. 2006 Dec;21(6):458-64. Abstract (PubMed)
  
• Moment analysis for kinetics of gene silencing by RNA interference
  Takahashi Y., Yamaoka K., Nishikawa M. and Takakura Y.
  Biotechnol Bioeng. 2006 Mar 5;93 (4):816-9. Abstract (PubMed)
  

• Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes
  Nishikawa M., Hyoudou K., Kobayashi Y., Umeyama Y., Takakura Y. and Hashida M.
  J Control Release. 2005 Dec 5;109 (1-3):101-7. Abstract (PubMed)
• Cellular uptake and activation characteristics of naked plasmid DNA and its cationic liposome complex in human macrophages
  Yamane I., Nishiakwa M. and Takakura Y.
  Int J Pharm. 2005 Nov 23;305 (1-2):145-53. Abstract (PubMed)
• Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference
  Matsui Y., Kobayashi N., Nishikawa M. and Takakura Y.
  Pharm Res. 2005 Dec;22 (12):2091-8. Abstract (PubMed)
• Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule
  Kawase A., Kobayashi N., Isaji K., Nishikawa M. and Takaura Y.
  Int J Pharm. 2005 Apr 11;293 (1-2):291-301. Abstract (PubMed)
• The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F(1) mice
  Ogawa Y., Yoshinaga T., Yasuda K., Nishikawa M. and Takakura Y.
  Immunol Lett. 2005 Oct 15;101 (1):32-40. Abstract (PubMed)
  
• Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells
  Maruyama M., Kishimoto M., Ishida K., Watanabe Y., Nishikawa M., Masuda S., Sasaki R. and Takakura Y.
  Arch Biochem Biophys. 2005 Jun 15;438(2):174-81. Abstract (PubMed)
• Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases
  Takahashi Y., Nishikawa M., Kobayashi N. and Takakura Y.
  J Control Release. 2005 Jul 20;105 (3):332-43. Abstract (PubMed)
  
• Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice
  Takemoto S., Nishikawa M. and Takakura Y.
  Pharm Res. 2005 Mar;22 (3):419-26. Abstract (PubMed)
  
• Permeability modulation of human intestinal Caco-2 cell monolayers by interferons
  Kawaguchi H., Akazawa Y., Watanabe Y. and Takakura Y.
  Eur J Pharm Biopharm. 2005 Jan;59 (1):45-50. Abstract (PubMed)
• Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways
  Yasuda K., Ogawa Y., Yamane I., Nishikawa M. and Takakura Y.
  J Leukoc Biol. 2005 Jan;77 (1):71-9. Abstract (PubMed)

2004

• Exogeneous expression of interferon-beta in cultured brain microvessel endothelial cells
  Nakamura M., Yamaguchi S., Watanabe Y., Yamashita F., Takakura Y. and Hashida M.
  Biol Pharm Bull. 2004 Sep;27 (9):1441-3. Abstract (PubMed)
• Inhibition of experimantal hepatic metastasis by targeted delivery of catalase in mice
  Nishikawa M., Tamada A., Hyodo K., Umeyama Y., Takahashi Y., Kobayashi Y., Kumai H., Ishida E., Staud F., Yabe Y., Takakura Y., Yamashita F. and Hashida M.
  Clin Exp Metastasis. 2004;21 (3):213-21. Abstract (PubMed)
• Secretion Mode and Subcellular Localization of Human Interferon- b Exogenously Expressed in Porcine Renal Epithelial LLC-PK ₁ Cells
  Nishio T., Maruyama M., Yoshida T., Watanabe Y., Nishikawa M. and Takakura Y.
  Biol Pharm Bull. 2004 Oct;27 (10):1653. Abstract (PubMed)
• Simultaneous Detection of DsRed2-tagged and EGFP-tagged Human b -Interferons in the Same Single Cells
  Maruyama M., Nishio T., Yoshida T., Ishida C., Ishida K., Watanabe Y., Nishikawa M. and Takakura Y.
  J Cell Biochem. 2004 Sep 15;93 (3):497. Abstract (PubMed)
• Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection
  Hisazumi J., Kobayashi N., Nishikawa M. and Takakura Y.
  Pharm Res. 2004 Jul;21 (7):1223-8. Abstract (PubMed)
• Subcellular trafficking of exogenously expressed interferon-beta in Madin-Darby canine kidney cells
  Maruyama M., Nishio T., Kato T., Yoshida T., Ishida C., Watanabe Y., Nishikawa M., Kaneda Y. and Takakura Y.
  J Cell Physiol. 2004 Oct;201 (1):117-25. Abstract (PubMed)
• Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen
  Ikenaga T., Yamasaki Y., Shakushiro K., Nishikawa M. and Takakura Y.
  Vaccine. 2004 Jun 30;22 (20):2609-16. Abstract (PubMed)
• Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor
  Furumoto K., Nagayama S., Ogawara K., Takakura Y., Hashida M., Higaki K. and Kimura T.
  J Control Release. 2004 May 31;97 (1):133-41. Abstract (PubMed)
• Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells
  Shakushiro K., Yamasaki Y., Nishikawa M. and Takakura Y.
  Immunology. 2004 Jun;112 (2):211-8. Abstract (PubMed)
• Hydrodynamic-based Procedure Invovlves Transient Hyperpermeability in the Hepatic Cellular Membrane: Implication of a Nonspecific Process in Efficient Intracellular Gene Delivery
  Kobayashi N., Nishikawa M., Hirata K. and Takakura Y.
  J Gene Med. 2004 May;6 (5):584-92. Abstract (PubMed)
• Hepatic delivery of particulates in the submicron range by a hydrodynamics-based procedure: implications for particulate gene delivery systems
  Kobayashi N., Hirata K., Chen S., Kawase A., Nishikawa M. and Takakura Y.
  J Gene Med. 2004 Apr;6 (4):455-63. Abstract (PubMed)
• Restricted Cytokine Production from Mouse Peritoneal Macrophages in Culture in spite of Extensive Uptake of Plasmid DNA
  Yasuda K., Kawano H., Yamane I., Ogawa Y., Yoshinaga T., Nishikawa M. and Takakura Y.
  Immunology. 2004 Mar;111 (3):282-90. Abstract (PubMed)
• Expression and Visualization of a Human Interferon-beta-Enhanced Green Fluorescent Protein Chimeric Molecule in Cultured Cells
  Nakamura M., Maruyama M., Yamashita F., Takakura Y., Hashida M. and Watanebe Y.
  Biol Pharm Bull. 2004 Mar;27 (3):411-4. Abstract (PubMed)
• An evaluation method for nonlinear local disposition in rat liver and kidney
  Kato T., Yamaoka K. and Takakura Y.
  Drug Metab Dispos. 2004 Feb;32 (2):230-4. Abstract (PubMed)
• Vector-based In Vivo RNA Interference : Dose- and Time- Dependent Suppression of Transgene Expression
  Kobayashi N., Matsui Y., Kawase A., Hirata K., Miyagishi M., Nishikawa M. and Takakura Y.
  J Pharmacol Exp Ther. 2004 Feb;308 (2):688-93. Epub 2003 Nov 10. Abstract (PubMed)
• Effect of interferon gamma on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouce
  Kawaguchi H., Matsui Y., Watanabe Y. and Takakura Y.
  J Pharmacol Exp Ther. 2004 Jan;308 (1):91-6. Epub 2003 Oct 20. Abstract (PubMed)

2003

• Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes
  Verbaan F., van Dam I., Takakura Y., Hashida M., Hennink W., Storm G. and Oussoren C. Eur J Pharm Sci. 2003 Dec;20 (4-5):419-27. Abstract (PubMed)
• Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study
  Nishikawa M., Nakano T., Okaba T., Hamaguchi N., Yamasaki Y., Takakura Y., Yamashita F. and Hashida M.
  Bioconjug Chem. 2003 Sep-Oct;14 (5):955-61. Abstract (PubMed)
• Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model
  Sakurai F., Terada T., Maruyama M., Watanabe Y., Yamashita F., Takakura Y. and Hashida M.
  Cancer Gene Ther. 2003 Sep;10 (9):661-8. Abstract (PubMed)
• Disposition and Gene Expression Characteristics in Solid Tumors and Skeletal Muscle after Directe Injection of Naked Plasmid DNA in Mice
  Kawase A., Nomura T., Yasuda K., Kobayashi N., Hashida M. and Takakura Y.
  J Pharm Shi. 2003 Jun;92 (6):1295-304. Abstract (PubMed)
• Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation : the influence of charge density and size of the proteins molecules
  Yamasaki Y., Hisazumi J., Yamaoka K. and Takakura Y.
  Eur J Pharm Shi. 2003 Apr;18 (5):305-12. Abstract (PubMed)

2002

• Pharmacokinetics and preventive effects of targeted catalase delivatives on hydrogen peroxide-induced injury in perfused rat liver
  Yabe Y., Kobatashi N., Nishikawa M., Mihara K., Yamashita F., Takakura Y. and Hashida M.
  Pharm Res. 2002 Dec;19 (12):1815-21. Abstract (PubMed)
• Therapeutic Effect of intavenous interferon gene delivery with naked plamid DNA in murine metastasis models
  Kobayashi N., Kuramoto T., Chen S., Watanabe Y. and Takakura Y.
  Mol Ther. 2002 Dec;6 (6):737-44. Abstract (PubMed)
• Efficient Uptake and rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism
  Yoshinaga T., Yasuda K., Ogawa Y. and Takakura Y.
  Biochem Biophys Res Commun. 2002 Dec 6;299 (3):389-94. Abstract (PubMed)
• Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes
  Akazawa Y., Kawaguchi H., Funahashi M., Watanabe Y., Yamaoka K., Hashida M. and Takakura Y.
  J Pharm Sci 2002 Oct;91 (10):2110-5. Abstract (PubMed)
• Imporant role of serum proteins associated on the surface of particles in their hepatic disposition
  Furumoto K., Ogawara K., Nagayama S., Takakura Y., Hashida M., Higaki K. and Kimura T.
  J Control Release. 2002 Sep 18;83 (1):89-96. Abstract (PubMed)
• The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes
  Sakurai F., Terada T., Yasuda K., Yamashita F., Takakura Y. and Hashida M.
  Gene Ther. 2002 Aug;9 (16):1120-6. Abstract (PubMed)
• Plasmid DNA Activates Murine Macrophages to Induce Inflammatory Cytokines in a CpG Motif-Independent Manner by Complex Formation with Cationic Liposomes
  Yasuda K., Ogawa Y., Kishimoto M., Takagi T., Hashida M. and Takakura Y.
  Biochem Biophys Res Commun. 2002 Apr 26;293 (1):344-348. Abstract (PubMed)
• Secretion polarity of interferon (IFN)-b in epithelial cell lines
  Nakanishi K., Watanabe Y., Maruyama M., Yamashita F., Takakura Y. and Hashida M.
  Arch Biochem Biophys. 2002 Jun 15;402 (2):201-7. Abstract (PubMed)
• Pharmacokinetic Analysis of In Vivo Disposition of Succinylated Proteins Targeted to Liver Non-parenchymal Cells via Scavenger Receptors: Importance of Molecular Size and Negative Charge Density for In Vivo Recognition by Receptors
  Yamasaki Y., Sumimoto K., Nishikawa M., Yamashita F., Yamaoka K., Hashida M. and Takakura Y.
  J Pharmacol Exp Ther. 2002 May;301 (2):467-477. Abstract (PubMed)
• Electric charge on protein regulates its absorption from the rat small intestine
  Nishikawa M., Hasegawa S., Yamashita F., Takakura Y. and Hashida M.
  Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282 (4):G711-G719. Abstract (PubMed)

2001

• Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: a possible carrier for Kuppfer cells
  Opanasopit P., Nishikawa M., Yamashita F., Takukura Y. and Hashida M.
  J Drug Target. 2001 9 (5):341-51. Abstract (PubMed)
• Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats
  Ogawara K., Furumoto K., Takakura Y., Hashida M., Higaki K. and Kimura T.
  J Control Release. 2001 Dec 13;77 (3):191-8. Abstract (PubMed)
• Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E1 using lactosylated poly (L-glutamic hydrazide) as a carrier
  Akamatsu K., Yamasaki Y., Nishikawa M., Takakura Y. and Hashida M.
  Biochem Pharmacol. 2001 Dec 1;62 (11):1531-1536. Abstract (PubMed)
• Effects of Erythrocytes and Serum Proteins on Lung Accumulation of Lipoplexes Containing Cholesterol or DOPE as a Helper Lipid in the Single-Pass Rat Lung Perfusion System
  Sakurai F., Nishioka T., Yamashita F., Takakura Y. and Hashida M.
  Eur J Pharm Biopharm. 2001 Sep;52 (2):165-172. Abstract (PubMed)
• Transport Characteristics of Ebastine and Its Metabolites across Human Intestinal Epithelial Caco-2 Cell Monolayers
  Imamura Y., Shimizu K., Yamashita F., Yamaoka K., Takakura Y. and Hashida M.
  Biol Pharm Bull. 2001 Aug;24 (8):930-934. Abstract (PubMed)
• Prevention of Neutrophil-Mediated Hepatic Ischemia/ Reperfusion Injury by SOD and Catalase Derivatives
  Yabe Y., Kobayashi N., Nishihashi T., Takahashi R., Nishikawa M., Takakura Y. and Hashida M.
  J Pharmacol Exp Ther. 2001 Sep;298 (3):894-899. Abstract (PubMed)
• Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: The role of the neutral helper lipid
  Sakurai F., Nishioka T., Saito H., Baba T., Okuda A., Matsumoto O., Taga T., Yamashita F., Takakura Y. and Hashida M.
  Gene Ther. 2001 May;8 (9):677-686. Abstract (PubMed)
• Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures
  Kobayashi N., Kuramoto T., Yamaoka K., Hashida M. and Takakura Y.
  J Pharmacol Exp Ther. 2001 Jun;297 (3):853-860. Abstract (PubMed)
• Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver
  Furumoto K., Ogawara K., Yoshida M., Takakura Y., Hashida M., Higaki K. and Kimura T.
  Biochim Biophys Acta. 2001 May 3;1526 (2):221-226. Abstract (PubMed)
• In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein
  Opanasopit P., Shiraishi K., Nishikawa M., Yamashita F., Takakura Y. and Hashida M.
  Am J Physiol Gastrointest Liver Physiol. 2001 May;280 (5):G879-G889. Abstract (PubMed)
• The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration
  Verbaan FJ., Oussoren C., van Dam IM., Takakura Y., Hashida M., Crommelin DJ., Hennink WE. and Storm G.
  Int J Pharm. 2001 Feb 19;214 (1-2):99-101. Abstract (PubMed)

2000

• The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier
  Kageyama T., Nakamura M., Yamasaki Y., Takakura Y., Hashida M., Kanai Y., Naito M., Tsuruo T., Minato N. and Shimohama S.
  Brain Res. 2000 Oct 6;879 (1-2):115-121. Abstract (PubMed)
• Extravasation of macromolecules
  Takakura Y. Mahato RI. and Hashida M.
  Adv Drug Deliv Rev. 2000 Oct 5;34 (1):93-108. Abstract (PubMed)
• Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system.
  Nishikawa M., Yamauchi M., Morimoto K., Ishida E., Takakura Y. and Hashida M.
  Gene Ther. 2000 Apr;7 (7):548-55. Abstract (PubMed)
• Intratumoral pharmacokinetics of oligonucleotides in tissue-isolated tumor perfusion system
  Nakajima S., Koshino Y., Nomura T., Yamashita F., Agrawal S., Takakura Y. and Hashida M.
  Antisense Nucleic Acid Drug Dev. 2000 Apr;10 (2):105-10. Abstract (PubMed)
• Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-Lysine) in mice
  Nishikawa M., Takemura S., Yamashita F., Takakura Y., Meijer DK., Hashida M. and Swart PJ.
  J Drug Target. 2000 8 (1):29-38. Abstract (PubMed)
• Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting
  Hashida M., Akamatsu K., Nishikawa M., Yamashita F., Yoshikawa H. and Takakura Y.
  Pharmazie. 2000 Mar;55 (3):202-5. Abstract (PubMed)
• Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular and trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression
  Sakurai F., Inoue R., Nishino Y., Okuda A., Matsumoto O., Taga T., Yamashita F., Takakura Y. and Hashida M.
  J Control Release. 2000 May;66 (2-3):255-269. Abstract (PubMed)
• Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages.
  Takagi T., Hashiguchi M., Hiramatsu T., Yamashita F., Takakura Y. and Hashida M.
  J Drug Target. 2000 7 (5):363-371. Abstract (PubMed)

【総説】

• Pharmacokinetic considerations regarding nonviral cancer gene therapy
  Makiya Nishikawa, Yoshinobu Takakura, Mitsuru Hashida
  Cancer Sci. 2008 May;99(5):856-62. Epub 2008 Feb 19. Abstract (PubMed)
• がん細胞へのsiRNAデリバリーとがん遺伝子治療への適用
  高橋有己、西川元也、高倉喜信
  薬学雑誌, 127(10), 1525-1531 (2007) Abstract (PubMed)
• Heat Shock Protein Derivatives for Delivery of Antigens to Antigen Presenting Cells
  Makiya Nishikawa, Seiji Takemoto and Yoshinobu Takakura
  Int J Pharm. 2008 Apr 16;354(1-2):23-7. Epub 2007 Sep 29. Abstract (PubMed)
• HSP-based tumor vaccines: state-of-the-art and future directions
  Yoshinobu Takakura, Seiji Takemoto and Makiya Nishikawa
  Curr Opin Mol Ther. 2007 Aug;9(4):385-91 Abstract (PubMed)
• 体内・細胞内動態制御機能を搭載した熱ショックタンパク質の開発とワクチンデリバリーへの応用
  西川元也、竹本誠二、高倉喜信
  薬学雑誌、127(2), 293-300 (2007)
• Role of immunostimulatory DNA and TLR9 in gene therapy
  Yasuda K., Wagner H. and Takakura Y.
  Crit Rev Ther Drug Carrier Syst. 2006;23(2):89-110. Abstract (PubMed)
• Pharmacokinetics of plasmid DNA-based non-viral gene medicine
  Nishikawa M., Takakura Y. and Hashida M.
  Adv Genet. 2005;53:47-68. Abstract (PubMed)
• The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels
  Kobayashi N., Nishikawa M. and Takakura Y.
  Adv Drug Deliv Rev. 2005 Apr 5;57(5):713-31. Abstract (PubMed)
• Theoretical considerations involving the pharmacokinetics of plasmid DNA
  Nishikawa M., Takakura Y. and Hashida M.
  Adv Drug Deliv Rev. 2005 Apr 5;57(5):675-88. Abstract (PubMed)
• Pharmacokinetics in gene delivery
  Takakura Y. and Hashida M.
  Adv Drug Deliv Rev. 2005 Apr 5;57(5):667-8.
• Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo
  Yamaoka K. and Takakura Y.
  Drug Metab Pharmacokinet. 2004 Dec;19(6):397-406. Abstract (PubMed)
• Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery
  Takakura Y., Nishikawa M., Yamashita F. and Hashida M.
  J Drug Target. 2002 Mar;10 (2):99-104. Abstract (PubMed)
• Cell-specific delivery of genes with glycosylated carriers
  Hashida M., Nishikawa M., Yamashita F. and Takakura Y.
  Adv Drug Delivery Rev. 2001 Nov 19;52 (3):187-196. Abstract (PubMed)
• Development of gene drug delivery systems based on pharmacokinetic studies
  Takakura Y., Nishikawa M., Yamashita F. and Hashida M.
  Eur J Pharm Sci. 2001 Apr;13 (1):71-76. Abstract (PubMed)
• [Drug delivery systems in gene therapy]
  Takakura Y.
  Nippon Rinsho. 1998 Mar;56 (3):691-5. Japanese. Abstract (PubMed)
• [Cancer gene therapy by direct intratumoral injection: gene expression and intratumoral pharmacokinetics of plasmid DNA]
  Nomura T., Takakura Y. and Hashida M.
  Gan To Kagaku Ryoho. 1997 Feb;24 (4):483-8. Japanese. Abstract (PubMed)
• Development of targeted delivery systems for nucleic acid drugs
  Mahato RI., Takakura Y. and Hashida M.
  J. Drug Target. 1997 4 (6):337-357. Abstract (PubMed)
• Nonviral vectors for in vivo gene delivery: Physicochemical and pharmacokinetic considerations
  Mahato RI., Takakura Y. and Hashida M.
  Crit Rev Ther Drug Carrier Syst. 1997 14 (2):133-172. Abstract (PubMed)
• [Development of drug delivery systems for macromolecular drugs]
  Takakura Y.
  Yakugaku Zasshi. 1996 Jul;116 (7):519-32. Japanese. Abstract (PubMed)
• Extravasation of macromolecules
  Takakura Y., Mahato RI. and Hashida M.
  Adv. Drug Delivery Rev. 34(1), 93-108 (1998) Abstract (PubMed)
• Delivery systems for gene drugs: The key to success of in vivo gene therapy
  Takakura Y. and Hashida M.
  Controlled Release Newsletter 15(1), 5-7 (1998)
• Delivery of plasmid DNA to endothelial cells
  Takakura Y. and Hashida M.
  Eur. J. Pharm. Biopharm. 42(4), 269-276 (1996)
• Macromolecular carrier systems for targeted drug delivery: Pharmacokinetic considerations on biodistribition
  Takakura Y. and Hashida M.
  Pharm. Res. 13(6), 820-831 (1996) Abstract (PubMed)
• Control of pharmacokinetic profiles of drug-macromolecule conjugates
  Takakura Y., Mahato RI., Nishikawa M. and Hashida M.
  Adv. Drug Delivery Rev. 19(3), 377-399 (1996)
• Pharmacokinetic evaluation of polymeric carriers
  Nishikawa M., Takakura Y. and Hashida M.
  Adv. Drug Delivery Rev. 21(2), 135-155 (1996)
• 高分子薬物のデリバリーシステムの開発に関する研究
  高倉喜信
  薬学雑誌、 116(7), 519-532 (1996)

【著書】

洋書

• Pharmacokinetics of polymer-plasmid DNA complex
  Nishikawa M., Takakura Y. and Hashida M.
  Polymeric Gene Delivery Principles and Applications, 63-76,
  M.M. Amiji, CRC Press, Boca Raton (2005)
• Gene Therapy and Gene Delivery
  Kobayashi N., Nishikawa M. and Takakura Y.
  Drug Delivery: Principles and Applications, 305-19,
  Eds. Binghe Wang, Teruna J. Siahaan, Richard A. Soltero, Wiley (2005)
• Basic pharmacokinetics of oligonucleotide and genes
  Nishikawa M., Takakura Y., Yamashita F. and Hashida M.
  Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics, 409-33,
  Eds. R.I. Mahato, S.W. Kim, Taylor & Francis (London) (2002)
• Cell Specific Targeting of Drug and Genes with Glycosylated Liposomes: Comparison with Glycosylated Poly (amino acids)
  Hashida M., Nishikawa M., Yamashita F. and Takakura Y.
  Controlled Drug Delivery, 201-211,
  Eds. Kinam Park, Randall J. Mrsny American Chemical Society (Washington, DC) (2000)
• Control of Disposition Profiles of Albumin and Proteinous Drugs by Chemical Modification
  Hashida M., Nishikawa M., Yamashita F. and Takakura Y.
  Proceedings of the International Symposium on Serum Albumin & _1-Acid Glycoprotein: from Basic Sciences to Clinical Applications, pp.265-275,
  Eds. Masaki Otagiri, Yuichi Sugiyama, Bernard Testa, Jan-Paul Tillement (2000)
• Pharmacokinetics of macromolecules and synthetic gene delivery systems
  Takakura Y. and Hashida M.
  Self-Assembling Complexes for Gene Delivery: From Laboratory to Clinical Trial, 295-306,
  Eds. A.V. Kabanov, P.L. Felgner, L.W. Seymour, John Wiley, and Sons Ltd. (England) (1998)
• Cell-specific delivery of proteins via receptor-mediated endocytosis
  Hashida M., Nishikawa M., Yamashita F. and Takakura Y.
  Alfred Benzon Symposium 43: Peptide and Protein Drug Delivery, 411-421,
  Eds. Sven Frｿkjｾr, Lona Christrup, Povl Krogsgaard-Larsen, Munksgaard (Denmark) (1998)
• Biofate of fat emulsions
  Nishikawa M., Takakura Y. and Hashida M.
  Submicron Emulsions in Drug Targeting and Delivery, 99-118,
  Eds. Simon Benita, Harwood Academic Publishers (Netherlands) (1998)
• Biopharmaceutical and pharmacokinetic aspects in the delivery of peptides and proteins
  Hashida M., Nishikawa M. and Takakura Y.
  Recent Advances in Peptide and Protein Delivery: 8th International Pharmaceutical Technology Symposium, 96-102,
  Eds. A.A. Hincal, F. Oner, Editions de Sante (France) (1998)
• Receptor-mediated cell specific delivery of drugs to the liver and kidney
  Hashida M., Nishikawa M. and Takakura Y.
  Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, 86-90,
  Eds. N. Ogata, S. W. Kim, J. Feijen, T. Okano, Springer (Verlag Tokyo) (1996)
• Development of delivery systems for antisense oligonucleotides
  Takakura Y., Mahato RI., Nomura T., Sawai K., Yoshida M., Kanamaru T. and Hashida M.
  Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, 357-358,
  Eds. N. Ogata, S. W. Kim, J. Feijen, T. Okano, Springer (Verlag Tokyo) (1996)
• Theoretical design of skin penetration enhancement via prodrug-enhancer combination based on a diffusion model
  Bando H., Yamashita F., Takakura Y. and Hashida M.
  Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, 363-364,
  Eds. N. Ogata, S. W. Kim, J. Feijen, T. Okano, Springer (Verlag Tokyo) (1996)

和書

• 第10章 8.2 体内動態
  高倉喜信
  リポソーム応用の新展開 602-605
  秋吉一成、辻井　薫　監修
  エヌ・ティー・エス (2005)
• 第3章 3.4 アンチセンス法における遺伝子デリバリー
  高倉喜信
  RNAi法とアンチセンス法：新しいRNA科学と応用 169-178
  関根光雄、多比良和誠　編
  講談社サイエンティフィック (2005)
• 第14章 遺伝子治療
  高倉喜信
  医薬品の開発と生産（スタンダード薬学シリーズ８）104-107
  日本薬学会　編　
  東京化学同人 (2005)
• 第 4 章　標的指向型DDS（ターゲティング）　１．受動ターゲティングと能動ターゲティング
  高倉喜信
  ドラッグデリバリーシステムの新展開-究極の薬物治療を目指して-, 120-8
  永井恒司　監修
  シーエムシー　（2004）
• 第 27 章　5.4　バイオコンジュゲート医薬品
  高倉喜信
  化学便覧　応用化学偏　第 6 版, 1455-7
  日本化学会　編
  丸善　（2004）
• 第 6 章ドラッグデリバリーシステム
  高倉喜信
  生物薬剤学， 211-232
  林　正弘，谷川原祐介　編
  南江堂 (2001)
• 第 3 章ドラッグデリバリーシステムの開発 3. 4 能動的ターゲティング製剤
  高倉喜信
  新ドラッグデリバリーシステム， 165-173
  永井恒司　監修
  シーエムシー (2000)
• その他の製剤・ DDS
  高倉喜信
  薬剤学・第 3 版， 211-232
  瀬崎　仁，木村聰城郎，橋田　充　編
  廣川書店 (2000)
• 遺伝子治療と DDS 2 遺伝子医薬品の体内動態とその制御
  高倉喜信
  今日の DDS 薬物送達システム、 361-368
  高橋俊雄，橋田　充　編
  医薬ジャーナル社 (1999)
• 各種疾患に対する DDS の応用 6 臓器移植における DDS を考慮した免疫抑制療法の開発
  吉村了勇，由良　博，岡　隆宏，高倉喜信，橋田　充
  今日の DDS 薬物送達システム、 341-352
  高橋俊雄，橋田　充　編
  医薬ジャーナル社 (1999)
• 第 4 章　ターゲティング
  高倉喜信
  改訂　図解・夢の薬剤 DDS, 53-74
  橋田　充　編
  薬業時報社 (1997)
• 第 13 改正日本薬局方解説書
  高倉喜信
  橋田　充　編
  廣川書店 (1996)

【解説・その他】

• 高分子化学に期待する
  高倉喜信
  Drug Delivery System, 23(6), 608 (2008)
• DDSを用いたsiRNAデリバリー
  高倉喜信
  炎症と免疫, 16(6), 23-28 (2008)
• DDSの基礎
  高倉喜信
  化学工業, 59(4), 3-6 (2008)
• 持続的遺伝子発現のためのアプローチ
  西川元也、高倉喜信
  遺伝子医学MOOK 5号「先端生物医学研究・医療のための遺伝子導入テクノロジーウイルスを用いない遺伝子導入法の材料、技術、方法論の新たな展開」、原島秀吉、田畑泰彦編、 118-123 (2006)
• がん治療のためのshort hairpin RNA発現ベクターのデリバリー
  高橋有己、西川元也、高倉喜信
  Drug Delivery System, 22(2), 123-130 (2007)
• 遺伝子・核酸医薬品のデリバリー
  高倉喜信
  Drug Delivery System, 22(2), 103 (2007)
• 遺伝子デリバリー：物理的手法に基づいたnaked pDNAのデリバリー
  高倉喜信
  ファームテクジャパン, 21(12), 132-135 (2005)
• 注射タイプのDDS製剤
  高倉喜信
  薬局, 56(8), 53-56 (2005)
• 薬学会賞受賞　橋田　充氏の業績
  高倉喜信
  ファルマシア, 41(4), 355 (2005)
• RNA干渉を利用した分子標的治療法の開発
  高橋有己、西川元也、高倉喜信
  医薬ジャーナル, 41(S-1), 54-58 (2005)
• はじめに：新薬展望2005　第�T部　分子標的治療〜最近の進歩〜
  高倉喜信
  医薬ジャーナル, 41(S-1), 19-20 (2005)
• DDS (drug delivery system)
  高倉喜信
  臨床整形外科, 40(1), 50-53 (2005)
• Hydrodynamics法を用いたRNAiベクターの導入法
  高橋有己、西川元也、高倉喜信
  実験医学別冊　改訂RNAi実験プロトコール, 173-178 (2004)
• RNAiによるマウス個体での遺伝子ノックダウン
  西川元也、小林直樹、高倉喜信
  Drug Delivery System, 19(4), 385-391 (2004)
• 癌の遺伝子治療−遺伝子デリバリーの研究−
  高倉喜信
  Biotherapy, 18(3), 253-257 (2004)
• GPEN　-Globalization of Pharmaceutics Education Network-
  高倉喜信
  ファームテクジャパン, 20(2), 31-33 (2004)
• Overview−糖とDDS
  高倉喜信
  Drug Delivery System, 19(1), 28-31 (2004)
• RNAiベクターの生体への応用
  西川元也、小林直樹、高倉喜信
  遺伝子医学：7(3) 65-69 (2003)
• 癌転移モデル−概論−
  高倉喜信
  日本臨床：61(増刊号8) 39-43 (2003)
• SiRNA・SiRNA発現ベクターデリバリーシステム
  西川元也、小林直樹、高倉喜信
  遺伝子医学：7(3) 65-69 (2003)
• ターゲティングと薬物治療
  高倉喜信
  遺伝子医学別冊：ドラッグデリバリーシステム　DDS技術の新たな展開とその活用法, 216-219 (2003)
• 遺伝子治療用製剤の将来と問題点
  高倉喜信
  生命とくすり, 19(1) 6-7 (2003)
• 私が薦めるこの一冊：ゲノムでわかることできること
  高倉喜信
  Pharmacy Today, 15(2), 38 (2002)
• DDS用語解説：アシアログリコプロテインレセプター
  高倉喜信
  Drug Delivery System, 17(1), 71 (2002)
• ドラッグデリバリーシステム（DDS）
  高倉喜信
  医学のあゆみ, 200(13), 1209-1210 (2002)
• ドラッグデリバリーシステムとマイクロマシン
  高倉喜信
  Drug Delivery System, 16(2), 71-76 (2001)
• 癌の転移モデル
  高倉喜信
  Drug Delivery System, 16(2), 97-105 (2001)
• DDS の夢
  猪狩康孝、菊池　寛、高倉喜信、水口裕之、奥平和穂
  ファルマシア、 37(5), 369-374 (2001)
• 大学院大学と薬学教育研究
  高倉喜信
  生命とくすり、 15(3), 4 (1999)
• マウス継代脳血管内皮細胞 (MBEC4) を用いた L-DOPA の脳血液関門輸送機構の解析−中性アミノ酸トランスポーターの関与について−
  景山　卓，中村　勝，下濱　俊，木村　淳，高倉喜信，橋田　充，内藤幹彦，鶴尾　隆
  Progress in Medicine, 19(3), 147-152 (1999)
• ドラッグデリバリーとバイオハイブリッド
  高倉喜信
  Bio Industry, 16(10), 26-32 (1999)
• パッシブターゲティングの意義
  高倉喜信，丸山一雄，横山昌幸
  Drug Delivery System, 14(6), 425-426 (1999)
• 高分子を利用したパッシブターゲティング
  高倉喜信
  Drug Delivery System, 14(6), 427-431 (1999)
• 遺伝子治療 (gene therapy) における DDS
  高倉喜信
  日本臨床 56(3), 139-143 (1998)
• DDS −最新の知見
  高倉喜信
  MEDICAL PHARMACY, 31, 16-19 (1997)
• 腫瘍内直接注入による癌の遺伝子治療：プラスミド DNA の腫瘍内動態とその発現
  野村武彦，高倉喜信，橋田　充
  癌と化学療法、 24(4), 483-488 (1997)
• 変性リポ蛋白の体内動態におけるスカベンジャー受容体の役割
  高倉喜信
  薬物動態、 12(6), 669 (1997)
• DDS と創剤
  高倉喜信
  ファルマシア、 32(1), 47-50 (1996)
• 高分子薬物のデリバリーシステムの開発に関する研究
  高倉喜信
  ファームテクジャパン、 12(6), 93-98 (1996)
• 高分子薬物の体内動態特性の解析と動態制御法の開発
  高倉喜信
  薬物動態、 11(4), 436-442 (1996)
• 遺伝子医薬品の DDS 開発とその問題点
  高倉喜信
  日本病院薬剤師会雑誌、 32(7/8), 819-820 (1996)
• プロドラッグ化と吸収促進剤適用との組み合わせによる Acyclovir の in vivo 経皮吸収改善
  坂東博人，佐橋美貴子，山下富義，高倉喜信，橋田　充
  Therapeutic Research, 17(9), 41-42 (1996)

【招待講演】

国際学会

• Interferon Gene Therapy against Metastatic Cancer
  Yoshinobu Takakura, Makiya Nishikawa
  Ehrlich II - 2nd World Conference on Magic Bullets, N?rnberg, (Germany), October 3-5 (2008)
• Optimization of Design and Delivery of Plasmid Vector for Interferon Gene Therapy
  Yoshinobu Takakura
  2008 KCRS Annual Conference: Research Networking for Future Therapy, Jeju Island (Korea), September 4-5 (2008)
• Nonviral Gene Delivery Based on Physical Methods in Combination with Naked Plasmid DNA
  Yoshinobu Takakura
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences (The 4th US-Japan Joint Conference), Nagoya (Japan), February 23 (2008)
• Design and Delivery of Plasmid DNA for In Vivo Cancer Gene Therapy and Genetic Vaccination.
  Takakura Y.
  Mini-Symposium for Nano-Bio Drug Delivery System, Seoul (Korea), Sep 1 (2006)
• In Vivo Plasmid DNA Delivery For Cancer Gene Therapy and Genetic Vaccination
  Takakura Y.
  The 1st FIP-APSTJ Joint Workshop on Gene Delivery, Sapporo (Japan), July 10-12 (2006)
• Plasmid DNA Delivery for In Vivo Cancer Gene Therapy
  Takakura Y.
  1st Indo-Japanese International Conference on Advances in Pharmaceutical Research and Technology, Mumbai (India), November 25-29 (2005)
• Delivery of siRNA-expressing Vectors for In Vivo RNAi
  Takakura Y., Kobayashi N., Miyagishi M., Taira K. and Nishikawa M.
  31th Annual Meeting and Exposition of the Controlled Release Society, Honolulu (U.S.A), June 12-16 (2004)
• Cytokine Gene Delivery to Polarized Epithelial Cells.
  Takakura Y.
  The 2nd Pharmaceutical Sciences World Congress, Kyoto (Japan), May 29 - June 3 (2004)
• Gene Delivery with Particulate Carriers
  Takakura Y., Nishikawa M., Yamashita F. and Hashida M.
  29th Annual Meeting and Exposition of the Controlled Release Society, Seoul (Korea), July 20-25 (2002)
• Plasmid DNA Uptake and Subsequent Activation in Macrophages and Dendritic Cells.
  Takakura　Y.
  The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy, Seoul (Korea) 18-19 April (2002)
• Interferon Gene Delivery to Polarized Epithelial Cells.
  Takakura Y.
  The 6th US-Japan Symposium on Drug Delivery Systems, Maui (U.S.A.) 16-21 December (2001)
• Development of hepatocyte-specific gene delivery systems based on pharmacokinetic studies.
  Takakura Y., Nishikawa M., Yamashita F. and Hashida M.
  15th Annual Meeting of the Academy of Pharmaceutical Science and Technology, Japan (APSTJ), San Francisco (U.S.A.) 15-16 April (2000)
• Targeted Delivery of Drugs and Genes.
  Takakura Y.
  Japan/Wales DDS Seminar, Kyoto (Japan) 7 September (2000)
• Pharmacokinetics of plasmid DNA and its complexes with cationic carriers after systemic and local administrations.
  Takakura Y. and Hashida M.
  AAPS Annual Meeting, San Francisco (U.S.A.) 15-19 November (1998)
• Pharmacokinetics of genes and antisense oligonucleotides.
  Takakura Y.
  Eighth Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Seattle, Washington (U.S.A.) 28-30 July (1996)

国内学会

• オーバービュー：遺伝子デリバリー
  高倉喜信
  第24回日本DDS学会、東京　6月29-30日 (2008)
• 遺伝子治療、DNAワクチン療法の最適化を目指した核酸医薬品のデザインとデリバリー
  高倉喜信
  日本血液学会・日本臨床血液学会合同総会、横浜　10月11-13日 (2007)
• がん遺伝子治療を目指した核酸医薬品のデリバリー
  高倉喜信
  第2回DDS熊本シンポジウム、熊本　7月28日 (2006)
• RNAi効果の薬物速度論的解析とin vivo遺伝子治療への展開
  高倉喜信
  第22回日本ＤＤＳ学会、東京　7月7-8日 (2006)
• DDSの基礎
  高倉喜信
  第23回医用高分子研究会講座、東京　11月21-22日 (2005)
• 遺伝子治療とDDS
  高倉喜信
  第12回臨床薬剤師のための講習会、金沢　7月11日 (2004)
• 肝臓特異的薬物・遺伝子デリバリーシステムの開発
  高倉喜信
  広島大学肝臓研究センター開設記念シンポジウム、広島　6月21日 (2004)
• 核酸医薬品のDDS開発と問題点
  高倉喜信
  異分野研究者交流促進事業フォーラム、高知　1月21-24日 (2004)
• 遺伝子治療とDDS
  高倉喜信
  第13回日本医療薬学会年会、神戸　9月28日 (2003)
• 微粒子薬物キャリアーの体内動態
  高倉喜信
  第7回薬物動態談話会セミナー、神戸　8月27-29日 (2003)
• 細胞の極性に応じた遺伝子発現挙動とその制御
  高倉喜信
  第13回創剤フォーラム談話会、東京　6月24日 (2003)
• ドラッグデリバリーシステム〜からだの中のくすりの動きを自由にあやつる〜
  高倉喜信
  第18回日本薬剤学会公開市民講演会、京都　4月3日 (2003)
• 核酸医薬品の体内動態制御戦略
  高倉喜信
  第12回アンチセンスシンポジウム、大阪　11月28-29日 (2002)
• 体内・細胞内動態制御に基づいた遺伝子医薬品の DDS
  高倉喜信
  第 16 回長崎 DDS 研究会、長崎、 12 月 7 日 (2001)
• 体内動態を考慮した DDS の開発
  高倉喜信
  第 3 回医薬品製造技術総合会議、東京、 4 月 25-28 日 (2000)
• 生物薬剤学若手研究者の国際交流 -GPEN-
  高倉喜信
  第 18 回生物薬剤学研究会、大阪、 6 月 9-10 日 (2000)
• 極性を持つ細胞を標的とした遺伝子デリバリー
  高倉喜信、橋田　充
  第 16 回日本 DDS 学会、秋田、 7 月 28-29 日 (2000)
• 体内動態制御に基づく遺伝子デリバリーシステムの構築
  高倉喜信
  日本薬学会第 119 年会、「遺伝子医薬品の分子設計と動態制御の最適化」、徳島、 3 月 31 日 (1999)
• ドラッグデリバリーとバイオハイブリッド
  高倉喜信
  第 14 回バイオハイブリッド研究会、横浜、 5 月 31 日 (1999)
• 体内動態制御に基づいた遺伝子医薬品デリバリーシステムの開発
  高倉喜信、橋田　充
  第 14 回日本臨床リウマチ学会総会、京都、 12 月 10-11 日 (1999)
• 遺伝子医薬品の体内動態とその制御
  高倉喜信
  第 40 回日本薬学会関東支部大会、神奈川、 10 月 19 日 (1996)
• 遺伝子医薬品の DDS
  高倉喜信
  第 18 回生体膜と薬物の相互作用シンポジウム、徳島、 11 月 15-16 日 (1996)