研究業績

研究業績　-Publication List- (updated Apr., 2008)

［原著論文］：
1. Goto Y., Hattori A., Mizutani S. and Tsujimoto M.
Asparatic acid-221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A
J. Biol. Chem., 282, 37074-37081 (2007)
2. Maruyama M., Hattori A., Goto. Y., Ueda M., Maeda M., Fujiwara H. and Tsujimoto M.
Laeverin/Aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases
J. Biol. Chem., 282, 20088-20096 (2007)
3. Goto Y., Hattori A., Ishii Y., Mizutani S. and Tsujimoto M.
Enzymatic properties of human aminopeptidase A : Regulation of its enzymatic activity by calcium and angiotensin IV
J. Biol. Chem., 281, 23503-23513 (2006)
4. Goto Y., Hattori A., Ishii Y. and Tsujimoto M.
Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP) /ER-aminopeptidase-1
FEBS Lett., 580, 1833-1838 (2006)
5. Fruci D., Ferracuti S., Limongi M.Z., Cunsolo V., Giorda E., Fraioli R., Sibilio L., Carroll O., Hattori A., van Endert P.M. and Giacomini P.
Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma and melanoma cell lines
J. Immunol., 176, 4869-4879 (2006)
6. Shido F., Ito T., Nomura S., Yamamoto E., Sumigama S., Ino K., Itakura A., Hattori A., Tsujimoto M., Mizutani S. and Kikkawa F.
Endoplasmic reticulum aminopeptidase1 mediates leukemia inhibitory factor-induced cell surface HLA-G expression in JEG-3 choriocarcinoma cells
Endocrinology, 147, 1780-1788 (2006)
7. Tanioka T., Hattori A., Mizutani S. and Tsujimoto M.
Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon- g
FEBS J., 272, 916-928 (2005)
8. Shibata D., Ando H., Iwase A., Nagasaka T., Hattori A., Tsujimoto M. and Mizutani S..
Distribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometrium
J. Histochem. Cytochem., 52, 1169-1175 (2004)
9. Watanabe Y., Shibata K., Kikkawa F., Kajiyama H., Ino K., Hattori A., Tsujimoto M. and Mizutani S.
Adipocyte-derived leucine aminopeptidase (A-LAP) suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system(RAS)
Clin. Cancer Res., 9, 6497-6503 (2003)
10. Ino K., Kikkawa F., Suzuki, T., Kajiyama H., Shibata K., Nomura S., Itakura A., Ito M., Nagasaka T., Hattori A., Tsujimoto M. and Mizutani S.
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells.
Lab. Invest., 73, 1799-1810 (2003)
11. Kazato H., Nomura, S., Ito S., Ito T., Watanabe, Y., Kajiyama H., Shibata, K., Ino K., Tamakoshi K., Hattori A., Kikkawa F., Nagasaka T., Tsujimoto M. and Mizutani S.
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer : Association with tumor grade and CA-125
Tumor Biol., 24, 203-208 (2003)
12. Nomura, Y., Abe, Y., Ishii, Y., Watanabe, M., Kobayashi, M., Hattori, A., and Tsujimoto, M.
Structural changes in the glycosaminoglycan chain of rat skin decrin with growth
J. Dermatol., 30, 655-664 (2003)
13. Tanioka T., Hattori A., Masuda S., Nomura Y., Nakayama H., Mizutani S., and Tsujimoto M.
Human leukocyte-derived arginine aminopeptidase : the third member of the oxytocinase subfamily of aminopeptidase
J. Biol. Chem., 278, 32275-32283 (2003)
14. Masuda S., Hattori A., Matsumoto H., Miyazawa S., Natori Y., Mizutani S., and Tsujimoto M.
Involvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells
Eur. J. Biochem., 270, 1988-1994 (2003)
15. Saric T., Chang S-C., Hattori A., York I.A., Markant S., Rock K.L., Tsujimoto M. and Goldberg A.L.
An IFN- γ -induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
Nat. Immunol., 3, 1169-1176 (2002)
16. Hattori A. , Matsumoto K., Mizutani S. and Tsujimoto M.
Genomic organization of human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene
J. Biochem., 130, 235-241 (2001)
17. Matsumoto H., Nagasaka T., Hattori A., Rogi T., Tsuruoka N., Mizutani S.and Tsujimoto M.
Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides
Eur. J. Biochem., 268, 3259-3266 (2001)
18. Hattori A. , Kitatani K., Matsumoto H., Miyazawa S., Rogi T., Tsuruoka N., Mizutani S., Natori Y., and Tsujimoto M.
Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells
J. Biochem., 128, 755-762 (2000)
19. Nakanishi Y., Nomura S., Okada M., Ito T., Katsumata Y., Kikkawa F., Hattori A., Tsujimoto M., and Mizutani S.
Immunoaffinity purification and characterization of native placental leucine aminoopeptidase/oxytocinase from human placenta
Placenta, 21, 628-634 (2000)
20. Matsumoto H., Rogi T., Yamashiro K., Kodama S., Tsuruoka N., Hattori A., Takio K., Mizutani S., and Tsujimoto M.
Characterization of recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells
Eur. J. Biochem., 267, 46-52 (2000)
21. Hattori A., Matsumoto H., Mizutani S., and Tsujimoto M.
Molecular cloning and functional expression of a novel aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase
J. Biochem., 125, 931-938 (1999)
22. Hattori A., Katayama M., Iwasaki S., Ishii K., Tsujimoto M., and Kohno M.
Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation
J. Neurochem., 72, 2264-2271 (1999)
23. Iwasaki S.,Hattori A., Sato M., Tsujimoto M., and Kohno M.
Characterization of the bone morphogenetic protein-2 as a neurotrophic factor : Induction of neuronal defferentiation of PC12 cells in the absence of mitogen-activated protein kinase activation
J. Biol. Chem., 271, 17360-17365 (1996)
24. Hattori A., Tsujimoto M., Hayashi K., and Kohno M.
Bone morphogenetic protein-2 is markedly synergistic with tumor necrosis factor in stimulating the production of nerve growth factor in fibroblasts
Biochem. Mol. Biol. Int., 38, 1095-1101 (1996)
25. Hattori A., Hayashi K., and Kohno M.
Tumor necrosis factor (TNF) stimulates the production of nerve growth factor in fibroblasts via the 55-kDa type 1 TNF receptor
FEBS Lett., 379, 157-160 (1996)
26. Chatani Y., Tanimura S., Miyoshi N., Hattori A., Sato M., and Kohno M.
Cell type-specific modulation of cell growth by transforming growth factor b1 does not correlate with mitogen-activated protein kinase activation
J. Biol. Chem., 270, 30686-30692 (1995)
27. Iwasaki S., Tsuruoka N., Hattori A., Sato M., Tsujimoto M., and Kohno M.
Distribution and characterization of specific cellular binding proteins for bone morphogenetic protein-2
J. Biol. Chem., 270, 5476-5482 (1995)
28. Hattori A., Iwasaki S., Murase K., Tsujimoto M., Sato M., Hayashi K., and Kohno M.
Tumor necrosis factor is markedly synergistic with interleukin 1 and interferon-g in stimulating the production of nerve growth factor in fibroblasts
FEBS Lett., 340, 177-180 (1994)
28. Murase K., Hattori A., Kohno M., and Hayashi K.
Stimulation of nerve growth factor synthesis / secretion in mouse astroglial cells by coenzymes
Biochem. Mol. Biol. Int., 30, 615-621 (1993)
30. Hattori A., Tanaka E., Murase K., Ishida N., Chatani Y., Tsujimoto M., Hayashi K., and Kohno M.
Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells
J. Biol. Chem., 268, 2577-2582 (1993)
31. Chatani Y., Itoh A., Tanaka E., Hattori A., Nakamura T., and Kohno M.
Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes
Biochem. Biophys. Res. Commun., 185, 860-866 (1992)
32. Kohno M., Chatani Y., Tanaka E., Hattori A., and Nishizawa N.
Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins : Potential role in integrating multiple mitogenic signalling pathways
Biochem. J., 287, 917-924 (1992)
33. Chatani Y., Tanaka E., Tobe K., Hattori A., Sato M., Tamemoto K., Nishizawa N., Nomoto H., Takeya T., Kadowaki T., Kasuga M., and Kohno M.
Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases / microtubule-associated protein 2 kinases
J. Biol. Chem., 267, 9911-9916 (1992)
［総説］
1. Mizutani S., Ishii M., Hattori A., Nomura S., Numaguchi Y., Tsujimoto M., Kobayshi H., Murohara T. and Wright J.W.
New insights into the importance of aminopeptidase A in hypertension
Heart Fail. Rev. 13, 273-284 (2008)
2. Tsujimoto M.*, Goto Y., Maruyama M. and Hattori A.
Biochemical and enzymatic properties of M1 family of aminopeptidases involved in the regulation of blood pressure
Heart Fail. Rev. 13, 285-291 (2008
3. Mizutani S., Shibata K., Kikkawa F., Hattori A., Tsujimoto M., Ishii M. and Kobayashi H.
Essential role of placental leucine aminopeptidase in gynecologic malignancy
Expert Opin. Ther. Targets, 11, 453-461 (2007)
4. 服部　明 , 辻本雅文
「M1アミノペプチダーゼの新たな生理機能」
日本血栓止血学会誌 　17巻1号　20-28(2006年)
5. 服部　明 , 辻本雅文
「小胞体アミノペプチダーゼの発見とその MHCクラスI 抗原ペプチドプロセシングにおける役割」
化学と生物　43巻11号　698-704(2005年)
6. Tsujimoto M. and Hattori A.
The oxytocinase subfamily of M1 aminopeptidases
Biochim. Biophys. Acta, 1751, 9-18 (2005)
7. Hattori A. and Tsujimoto M.
Processing of antigenic peptides by aminopeptidases.
Biol. Pharm. Bull., 27, 777-80 (2004)
8. 服部　明 , 辻本雅文
「オキシトシナーゼサブファミリー− S M1アミノペプチダーゼの新しいサブファミリーの同定とその生理機能」
生化学　75巻 9号　1225-1230 (2003年)
9. Matsumoto H., Hattori A., Mizutani S.,and Tsujimoto M.
Cleavage of peptide hormones by placental leucine aminopeptidase/oxytocinase
Cell-Surface Aminopeptidases : Basic and Clinical Aspects, (eds. lang=IT Mizutani S., Turner A.J., Nomura S. and Ino K.) S Elsevier Science B.V. , Amsterdam, 295-299 (2001)
10. Hattori, A., Matsumoto, H., Mizutani, S., and Tsujimoto, M.
Biochemical characterzation of placental leucine aminopeptidase/oxytocinase and its related enzyme, adipocyte-derived leucine aminopeptidase
Cell-Surface Aminopeptidases : Basic and Clinical Aspects, (eds. lang=IT Mizutani S., Turner A.J., Nomura S. and Ino K.) Elsevier Science B.V. , Amsterdam, 339-343 (2001)
11. Tsujimoto, M., Matsumoto, H., and Hattori, A.
Biochemical characterzation of placental leucine aminopeptidase/oxytocinase and its related enzyme, adipocyte-derived leucine aminopeptidase
Cell-Surface Aminopeptidases : Basic and Clinical Aspects, (eds. lang=IT Mizutani S., Turner A.J., Nomura S. and Ino K.) S Elsevier Science B.V. , Amsterdam, 265-274 (2001)
12. Tsujimoto, M., Hattori, A., and Mizutani, S.
Leucine aminopeptidase
The Encyclopedia of Molecular Medicine (eds. lang=IT Kazazian Jr. H.G. et al.) John Wiley & Sons, New York, 1909-1910 (vol.3)　 (2001)
13. 服部　明 、辻本雅文
「アミノペプチダーゼをめぐる最近の話題」
ファルマシア　36巻10号　865-869（2000年）
14. 服部 明、松下佳代、河野通明
「新しい理念に基づく治療の開発とその可能性　TNF α(腫瘍壊死因子）」
現代医療　29巻　1187-1193（1997年）
15. 河野通明、服部 明、山口裕之
「神経成長因子/PC12細胞系を利用したチューブリン阻害物質の検定法」
癌と化学療法　24巻　164-177（1997年）
16. 服部 明、河野通明
「Trkファミリー」
生体の科学　46巻5号　564-565（1995年）
17. 服部 明、河野通明
「TNF/NGF受容体スーパーファミリー」
生体の科学　46巻5 号　561-563（1995年）
［招待講演］
1. 平成14年10月
第77回生化学会
“ER retention mechanism of an antigen-trimming aminopeptidase, adipocyte-derived leucine aminopeptidase/ endoplasmic reticulum aminopeptidase I”
2. 平成15 年11 月
Satellite Meeting of the 3rd IPS Meeting Commemorating Prof. Katsunuma’s 77 Aniversary
“Identification of an intramolecular domain necessary for the retention in the endoplasmic reticulum of adiposyte-derived leucine aminopeptidase”
3. 平成18年6月
International Symposium on Medical and Biological Perspectives in Proteases and Their Inhibitors Satellite Meeting of the 20th IUBMB International Congress and 11th FAOBMB Congress
“Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase(A-LAP)/ER-aminopeptidase-1”