Publication -Miscellaneous-

[Publications] [Review] [Miscellaneous]
[2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002]

2009

  1. Kobayashi K., Narumi T., Oishi S., Ohno H., Fujii N.
    Diastereoselective synthesis of trifluoromethylalkene dipeptide isosteres based on nucleophilic trifluoromethylation.
    Peptide Science 2008 (2009), 13-14. (Conference Abstract)

  2. Katagiri F., Nagai K., Tomita K., Kida A., Oishi S., Itoh H., Doi R., Fujii N., Takeyama M.
    Utility of plasma bioactive peptides levels as biomarkers.
    Peptide Science 2008 (2009), 123-126. (Conference Abstract)

  3. Kamitani H., Kodera Y., Watanabe K., Narumi T., Ohno H., Oishi S., Fujii N.
    Diastereoselective synthesis of (Z)-fluoroalkene dipeptide isostere and the application to a HIV membrane fusion inhibitor.
    Peptide Science 2008 (2009), 161-162. (Conference Abstract)

  4. Kajiwara K., Tokiwa R., Watanabe K., Ohno H., Izumi K., Kodama E., Matsuoka M., Oishi S., Fujii N.
    Bioorganic synthesis of end-capped HIV-1 fusion inhibitor SC35EK.
    Peptide Science 2008 (2009), 203-204. (Conference Abstract)

  5. Watabe T., Oishi S., Watanabe K., Ohno H., Nakano H., Nakatsu T., Kato H., Izumi K., Kodama E., Matsuoka M., Fujii N.
    X-ray crystallographic study of the HIV-1 fusion inhibitor against the drug-resistant N43D variant.
    Peptide Science 2008 (2009), 229-232. (Conference Abstract)

  6. Tomita K., Oishi S., Ohno H., Fujii N.
    Development of novel GPR54 agonists with resistance to degradation by MMP.
    Peptide Science 2008 (2009), 233-234. (Conference Abstract)

  7. Watanabe K., Ito S., Ohno H., Izumi K., Kodama E., Matsuoka M., Oishi S., Fujii N.
    Structure activity relationship study of the helix-inducible motifs in HIV fusion inhibitors.
    Peptide Science 2008 (2009), 257-258. (Conference Abstract)

  8. Tanaka M., Watanabe K., Ohno H., Izumi K., Kodama E., Matsuoka M., Oishi S., Fujii N.
    Identification of novel HIV-1 fusion inhibitors by template-assisted peptide aldehyde ligation..
    Peptide Science 2008 (2009), 361-362. (Conference Abstract)

  9. Oishi S, Ito S, Nishikawa H, Tanaka M, Ohno H, Otaka A, Izumi K, Kodama E, Matsuoka M, Fujii N.
    Development of a novel fusion inhibitor against T-20-resistant HIV-1.
    Adv Exp Med Biol. 611 (2009), 389-391.

  10. Tomita K, Narumi T, Niida A, Oishi S, Ohno H, Fujii N.
    Synthesis and application of (Z)-alkene- and (E)-fluoroalkene-dipeptide isosteres as cis-amide equivalents.
    Adv Exp Med Biol. 611 (2009), 365-366.

  11. Tamamura H, Tanaka T, Tsutsumi H, Nemoto K, Mizokami S, Ohashi N, Oishi S, Fujii N.
    Stereoselective synthesis of peptidomimetics based on acid-catalyzed ring-opening of beta-aziridinyl-alpha,beta-enoates.
    Adv Exp Med Biol. 611 (2009), 149-150.

  12. Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N
    Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy.
    Adv Exp Med Biol. 611 (2009), 145-146.



2008

  1. 大石真也、藤井信孝
    ハイスループットスクリーニング
    インシリコ創 薬科学（3.3節・京都廣川書店） (2008), 63-74. (Book)

  2. 掛谷秀昭、大石真也、矢倉徹、藤井信孝
    化合物ライブラリー
    インシリコ創 薬科学（3.2節・京都廣川書店） (2008), 46-63. (Book)

  3. Masuda, R.; Oishi, S.; Ueda, S.; Goto, Y.; Ohno, H.; Evans, B.; Peiper, S. C.; Hirasawa, A.; Tsujimoto, G.; Kodama, E.; Matsuoka, M.; Fujii, N.
    Synthesis and application of novel fluorescence-labeled CXCR4 antagonists.
    Peptide Science 2007 (2008), 403-404. (Conference Abstract)

  4. Yano, Y.; Yano, A.; Oishi, S.; Sugimoto, Y.; Tsujimoto, G.; Fujii, N.; Matsuzaki, K.
    Specific fluorescence labeling of membrane receptors in living cells using coiled-coil tag.
    Peptide Science 2007 (2008), 395-398. (Conference Abstract)

  5. Watanabe, K.; Ito, S.; Nishikawa, H.; Tanaka, M.; Oishi, S.; Ohno, H.; Izumi, K.; Kodama, E.; Matsuoka, M.; Fujii, N.
    Helix inducible motifs affect helicity and bioactivity of anti-HIV peptides.
    Peptide Science 2007 (2008), 311-312. (Conference Abstract)

  6. Shimbo, T.; Yano, Y.; Oishi, S.; Fujii, N.; Sugimoto, Y.; Matsuzaki, K.
    Properties of intracellular fragment peptides of mouse prostagladin E2 receptor EP3 isoform.
    Peptide Science 2007 (2008), 309-310. (Conference Abstract)

  7. Narumi, T.; Tomita, K.; Inokuchi, E.; Kobayashi, K.; Oishi, S.; Ohno, H.; Fujii, N.
    Fluoroalkene skeleton as a peptide bond mimetic: its scope and limitations.
    Peptide Science 2007 (2008), 25-26.( Conference Abstract)

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2007


  1. Ohno H, Tomioka K.
    Synthesis by substitution, linear allene, in science of synthesis.
    (2007)(Book)

  2. Wang Z-X., Tamamura H., Frilot N., Broach J., Fujii N., Peiper S.C.
    Screening and characterization of cyclic pentapeptide CXCR4 antagonists/inverse agonists using a pheromone responsive reporter gene in Saccharomyces cerevisiae: utility of G protein coupled receptor constitutively active mutants.
    Chemokine Biology--Basic Research and Clinical Application, 2 61-77(2007)(Book)

  3. 大石真也、藤井信孝
    ケミカルライゲーション─生合成でつくれないタンパク質をつくる
    (2007)(commentary)

  4. Narumi T., Kodera Y., Tomita K., Inokuchi E., Oishi S., Ohno H., Fujii N.
    Diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres: Lys-Lys and Glu-Glu type FADIs.
    Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007 ORGN-601 (2007) (Conference Abstract)

  5. Narumi T., Inokuchi E., Tomita K., Oishi S., Ohno H., Fujii N.
    Unprecedented palladium-mediated carbon-fluorine bond cleavage: Relevance to the synthesis of fluoroalkene dipeptidomimetics.
    Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 ORGN-829 (2007) (Conference Abstract)

  6. Ohta Y., Oisni S., Fujii N., Ohno H.
    Construction of 2-(aminomethyl)indole motif by Cu-catalyzed multi-component reaction.
    Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007 ORGN-834 (2007) (Conference Abstract)

  7. Oishi, S.; Tomita, K.; Niida, A.; Akamatsu, M.; Masui, T.; Doi, R.; Navenot, J.-M.; Wang, Z.; Peiper, S. C.; Fujii, N.
    Discovery of novel low-molecular-weight GPR54 agonist.
    Peptides 2006, Proceedings of the 29th European Peptide Symposium (2007), 400-401. (Conference Abstract)

  8. Narumi, T.; Tomita, K.; Niida, A.; Oishi, S.; Ohno, H.; Fujii, N.
    Diastereoselective synthesis of (Z)-fluoroalkene dipeptide isosteres based on organocopper-mediated reduction/direct alkylation, via transmetalation.
    Peptides 2006, Proceedings of the 29th European Peptide Symposium (2007), 614-615. (Conference Abstract)

  9. Tamamura, H.; Tsutsumi, H.; Masuno, H.; Ogawa, T.; Hiramatsu, K.; Araki, T.; Ueda, S.; Oishi, S.; Esaka, A.; Tanaka, T.; Ohashi, N.; Wang, Z.; Peiper, S. C.; Trent, J. O.; Fujii, N.
    Synthesis and biological evaluation of CXCR4 antagonists as pharmaceutical agents.
    Peptides 2006, Proceedings of the 29th European Peptide Symposium (2007), 110-111. (Conference Abstract)

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2006

  1. 藤井信孝、大石真也、大高章
    プロテオミクスを基盤とするケミカルバ イオロジー─情報から制御へ
    (2006)(Book)

  2. Ueda S., Oishi S., Wang Z-X., Ohno H., Peiper S.C., Fujii N.
    Structure-activity relationship studies on cyclic peptide-based CXCR4 antagonists: Side-chain and backbone modifications.
    Abstracts ofPapers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006 MEDI-164 (2006) (Conference Abstract)

  3. Fujii N., Oishi S., Narumi T., Tomita K., Ohno H.
    From amino acids to peptide isosteres: Implications to peptide-lead drug templates for genome-lead drug discovery.
    Abstracts ofPapers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006 ORGN-248 (2006) (Conference Abstract)

  4. Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
    Structure-activity relationship studies on GPR54 agonists.
    Peptide Science (2006) 43rd 8 (2006) (Conference Proceeding)

  5. Tanaka M., Oishi S., Ohno H., Fujii N.
    A novel oxazolidine linker for the synthesis of peptide aldehydes.
    Peptide Science (2006) 43rd 58 (2006) (Conference Proceeding)

  6. Ohta Y., Itoh S., Fujii N., Otaka A.
    Synthesis of peptide thioester based on N-S acyl transfer utilizing cysteine-derived acyloxazolidinone with practical application to peptide synthesis.
    Peptide Science (2006) Volume Date 2005, 42nd 19-22 (2006) (Conference Proceeding)

  7. Konno H., Kubo K., Makabe H., Fujii N., Nosaka K., Akaji K.
    Synthetic studies of tokaramide A and miraziridine A isolated from marine sponge Theonella aff. mirabilis.
    Peptide Science (2006) Volume Date 2005, 42nd 47-50 (2006) (Conference Proceeding)

  8. Tamamura H., Hiramatsu K., Araki T., Ueda S., Oishi S., Esaka A., Wang Z.-X., Peiper S.C., Trent J.O., Nakashima H., Yamamoto N., Otaka A., Fujii N.
    Synthesis and biological evaluation of peptidomimetic analogs of the CXCR4 antagonist FC131.
    Peptide Science (2006) Volume Date 2005, 42nd 61-62 (2006) (Conference Proceeding)

  9. Narumi T., Niida A., Tomita K., Oishi S., Ohno H., Otaka A., Fujii N.
    Endeavors for highly stereoselective synthesis of functionalized fluoroalkene dipeptide isosteres.
    Peptide Science (2006) Volume Date 2005, 42nd 87-88 (2006) (Conference Proceeding)

  10. Sasaki Y., Niida A., Tsuji T., Fujii N., Otaka A.
    Synthesis of (Z)-alkene cis-Ala-Pro mimetics using organocopper reagents.
    Peptide Science (2006) Volume Date 2005, 42nd 89-92 (2006) (Conference Proceeding)

  11. Tomita K., Niida A., Oishi S., Ohno H., Otaka A., Fujii N.
    Structure-activity relationship study on hOT7T175 agonist with RW-amide.
    Peptide Science (2006) Volume Date 2005, 42nd 205-206 (2006) (Conference Proceeding)

  12. Niida A., Tomita K., Tanigaki H., Terada T., Mizumoto M., Ohno H., Tamamura H., Otaka A., Inui K., Fujii N.
    Synthesis of alkene type dipeptide isosteres and their use to probe the structural requirements of peptide transporter (PEPT1).
    Peptide Science (2006) Volume Date 2005, 42nd 427-428 (2006) (Conference Proceeding)

  13. Tamamura H., Hanaoka H., Tsutsumi H., Ohashi N., Tanaka T., Mori T., Mukai T., Doi R., Saji H., Fujii N.
    Development of chemical probes for the chemokine receptor CXCR4 involving radiolabeled T140 analogs.
    Peptide Science (2006) 43rd 254 (2006) (Conference Proceeding)

  14. Tamamura H., Tsutsumi H., Hiramatsu K., Araki T., Ueda S., Oishi S., Masuno H., Tanaka T., Ohashi N., Mizokami S., Ogawa T., Wang Z.-X., Peiper S.C., Trent J.O., Nakashima H., Yamamoto N., Fujii N.
    Development of the chemokine receptor CXCR4 antagonists as multi-pharmaceutical agents involving a new class of low molecular weight antagonists.
    Peptide Science (2006) 43rd 279 (2006) (Conference Proceeding)

  15. Katagiri F., Tomita K., Oishi S., Takeyama M., Fujii N.
    Establishment and clinical application of an enzyme immunoassay for metastin to determination of the human plasma levels.
    Peptide Science (2006) 43rd 297-298 (2006) (Conference Proceeding)

  16. Tsuji T., Sasaki Y., Yamaguchi K., Shigenaga A., Fujii N., Otaka A.
    Synthesis of (Z)-alkene cis-Xaa-Pro type dipeptide isosteres using organocopper-mediated anti-SN2' reactions.
    Peptide Science (2006) 43rd 327 (2006) (Conference Proceeding)

  17. Takaki, S.; Kato, K.; Yokoyama, F.; Suzuki, N.; Kikkawa, Y.; Oishi, S.; Nomizu, M.
    Cyclic analogs derived from laminin enhanced the biological activities.
    Peptide Science 2006 (2006), 171-172. (Conference Proceeding)

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2005


  1. Ohno H.
    Vinylaziridines in organic synthesis, in aziridines and epoxides in organic synthesis.
    Yudin A, Eds.; Wiley-VCH: Weinheim (2005)(Book)

  2. Tamamura H., Araki T., Esaka A., Ueda S., Oishi S., Wang Z.-X., Peiper S.C., Otaka A., Fujii N.
    Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetrapeptide-scaffolds.
    Peptide Science (2005) Volume Date 2004, 41st 509-510 (2005) (Conference Proceeding)

  3. Kato T., Tamamura H., Otaka A., Fujii N.
    Synthesis of β-secretase inhibitors -containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies.
    Peptide Science (2005) Volume Date 2004, 41st 515-516 (2005) (Conference Proceeding)

  4. Ueda S., Otaka A., Tamamura H., Fujii N.
    4-(dimethylamino)phenacyl group: new photoremovable protecting group for amines and carboxylic acids.
    Peptide Science (2005) Volume Date 2004, 41st 599-602 (2005) (Conference Proceeding)

  5. Tamamura H., Hiramatsu K., Ueda S., Araki T., Takenaga M., Igarashi R., Hori A., Kanzaki N., Fujisawa M., Nakashima H., Yamamoto N., Otaka A., Fujii N.
    The chemokine receptor CXCR4 as a therapeutic target for several diseases including AIDS, cancer and rheumatoid arthritis.
    Peptide Science (2005) Volume Date 2004, 41st 121-122 (2005) (Conference Proceeding)

  6. Niida A., Mizumoto M., Sasaki Y., Tamamura H., Otaka A., Fujii N.
    Stereoselective synthesis of diketopiperazine mimetics as promising scaffolds for drug discovery utilizing organocopper-mediated anti-SN2' reaction.
    Peptide Science (2005) Volume Date 2004, 41st 169-172 (2005) (Conference Proceeding)

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2004


  1. Zhang W.B., Wang Z.X., Murphy J.L., Fujii N., Broach J., Peiper S.C.
    Functional expression of CXCR4 in S. cerevisiae: development of tools for mechanistic and pharmacologic studies.
    Chemokine Roles in Immunoregulation and Disease., ed by P.M. Murphy; R. Horuk, Springer, 45 125-152 (2004)(Book)

  2. Ohno H., Nagaoka Y., Tomioka K.
    Enantioselective synthesis of allenes.
    In Modern Allene Chemistry; A. S. K. Hashmi, N. Krause, Eds.; Wiley-VCH: Weinheim, (2004)(Book)

2003


  1. Ueda S., Tomita K., Otaka A., Tamamura H., Yano Y., Matsuzaki K., Fujii N.
    Synthetic studies on 7TM-GPCR (I): Lipid bilayer assisted membrane peptide ligation.
    Peptide Science (2003) Volume Date 2004, 40th 53-56 (2003) (Conference Proceeding)

  2. Tamamura H., Hori A., Kanzaki N., Hiramatsu K., Mizumoto M., Nakashima H., Yamamoto N., Otaka A., Fujii N.
    CXCR4 antagonists identified as anti-cancer-metastatic agents.
    Peptide Science (2003) Volume Date 2004, 40th 65-68 (2003) (Conference Proceeding)

  3. Nomizu M., Suzuki N., Yokoyama F., Yasui T., Oishi S., Fujii N., Nishi N.
    Biological activity of a cyclic peptide from laminin α1 chain loop region. 1 .
    Peptide Science (2003) Volume Date 2004, 40th 115-118 (2003) (Conference Proceeding)

  4. Araki T., Ueda S., Hiramatsu K., Oishi S., Tamamura H., Otaka A., Fujii N., Kusano S., Terakubo S., Nakashima H., Wang Z.-X., Peiper S.C.
    A new strategy for molecular-size reduction of bioactive peptide, using two orthogonal libraries of cyclic peptides.
    Peptide Science (2003) Volume Date 2004, 40th 207-210 (2003) (Conference Proceeding)

  5. Kato T., Tamamura H., Otaka A., Fujii N.
    Development of potent β-secretase-inhibitors containing a hydroxyethylamine dipeptide isostere.
    Peptide Science (2003) Volume Date 2004, 40th 231-234 (2003) (Conference Proceeding)

  6. Mizokami S., Tamamura H., Hiramatsu K., Mizumoto M., Akamatsu M., Nakashima H., Wang Z.-X., Peiper S.C., Yamamoto N., Otaka A., Fujii N.
    New leads of low molecular weight CXCR4 antagonists based on enhancement of the T140-based pharmacophores.
    Peptide Science (2003) Volume Date 2004, 40th 285-288 (2003) (Conference Proceeding)

  7. Otaka A., Nakamura M., Kodama E., Nakamura S., Nakano H., Uchiyama S., Tamamura H., Matsuoka M., Kobayashi Y., Fujii N.
    Development of fusion-inhibiting anti-HIV-1 peptides based on the structure of molecular complex involved in HIV-1-cell fusion.
    Peptide Science (2003) Volume Date 2002, 39th 65-68 (2003) (Conference Proceeding)

  8. Nemoto K., Tamamura H., Mizokami S., Oishi S., Otaka A., Fujii N.
    Acid-catalyzed ring-opening reactions of β-aziridinyl- -α,β-enoates and their application.
    Peptide Science (2003) Volume Date 2002, 39th 139-142 (2003) (Conference Proceeding)

  9. Tamamura H., Kato T., Hori T., Otaka A., Fujii N.
    Stereoselective synthesis of peptidomimetics with hydroxyethylamine dipeptide isosteres utilizing aza-Payne rearrangement and O,N-acyl transfer reactions.
    Peptide Science (2003) Volume Date 2002, 39th 143-146 (2003) (Conference Proceeding)

  10. Hiramatsu K., Tamamura H., Nakashima H., Otaka A., Fujii N.
    Synthesis of CXCR4 antagonists, T140 derivatives with improved biostability, and their SAR study.
    Peptide Science (2003) Volume Date 2002, 39th 213-216 (2003) (Conference Proceeding)

  11. Otaka A., Sasaki Y., Katagiri F., Oishi S., Tamamura H., Fujii N.
    Synthesis of (E)-alkene trans-Xaa-Pro mimetics using organocopper reagents.
    Peptide Science (2003) Volume Date 2002, 39th 357-360 (2003) (Conference Proceeding)

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2002


  1. Tamamura H., Hiramatsu K., Omagari A., Oishi S., Nakashima H., Peiper S.C., Otaka A., Fujii N.
    Development of selective CXCR4 inhibitors with strong anti-HIV activity.
    Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002 MEDI-207 (2002) (Conference Abstract)

  2. Oishi S., Kamano T., Niida A., Tamamura H., Otaka A., Fujii N.
    Organocopper-mediated stereoselective synthesis of multi-substituted alkene dipeptide isosteres and application to cyclic RGD peptides.
    Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug. 31-Sept. 6, 2002 244-245 (2002) (Conference Proceeding)

  3. Otaka A., Nakamura M., Kodama E., Uchiyama S., Tamamura H., Kobayashi Y., Matsuoka M., Fujii N.
    Artificial remodeling of gp41-C34 peptide leads to effective HIV fusion inhibitor with high anti-HIV activity.
    Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug. 31-Sept. 6, 2002 838-839 (2002) (Conference Proceeding)

  4. Niida A., Oishi S., Kamano T., Tamamura H., Otaka A., Fujii N.
    Synthesis of Ψ[(E)-CMe:CMe]- and [(Ψ[(E)-CMe:CH]-type alkene dipeptide isosteres from a chiral amino acid.
    Peptide Science (2002) Volume Date 2001, 38th 237-240 (2002) (Conference Proceeding)

  5. Oishi S., Kamano T., Niida A., Tamamura H., Otaka A., Fujii N.
    Synthesis ofψ[(E)-CH:CMe]- and [(ψ[(Z)-CH:CMe]-type dipeptide isosteres and their application to a cyclic RGD peptide.
    Peptide Science (2002) Volume Date 2001, 38th 241-244 (2002) (Conference Proceeding)

  6. Takeshima K., Chikushi A., Kobayashi S., Lee K.-K., Yonehara S., Otaka A., Fujii N., Matsuzaki K.
    Translocation of basic peptides through human cell membranes.
    Peptide Science (2002) Volume Date 2001, 38th 321-324 (2002) (Conference Proceeding)

  7. Nakamura M., Otaka A., Kodama E., Matsuoka M., Uchiyama S., Nakamura S., Kobayashi Y., Tamamura H., Fujii N.
    Design and synthesis of highly active anti-HIV peptide based on Gp41-C34 peptide.
    Peptide Science (2002) Volume Date 2001, 38th 73-76 (2002) (Conference Proceeding)

  8. Hiramatsu K., Tamamura H., Omagari A., Nakashima H., Xu Y., Matsuoka M., Otaka A., Fujii N.
    Synthesis of novel anti-HIV peptides based on a CXCR4 antagonist, T140, and their SAR study.
    Peptide Science (2002) Volume Date 2001, 38th 175-178 (2002) (Conference Proceeding)

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