International Conferences
2022 擭
- Globalization of Pharmaceutics Education Network 2022 (GPEN2022), (Minneapolis), October 19-22 (2022)
- Investigation of in vivo behavior of extracellular vesicles with different sizes after intraduodenal administration
Yuki Kobayashi, Momoko Naiki, Ayane Yabuta Yuki Takahashi, Yoshinobu Takakura
-
2021 擭
- Globalization of Pharmaceutics Education Network 2022 (GPEN2022), (Minneapolis), Octomber 19-22 (2022)
- Immunostimulatory Activity of DNA Dendrimers
Yuki Kobayashi, Momoko Naiki, Ayane Yabuta Yuki Takahashi, Yoshinobu Takakura
-
- 2021 CSPS/PSJ/CC-CRS SYMPOSIUM, (Online), June 1-4 (2021)
- Development of DNA supramolecules utilizing rolling circle amplification and hydrophobic interaction for efficient immunotherapy
Koichi Ito, Mutsumi Kariya, Yuki Takahashi, Yoshinobu Takakura.
- Development of allergic rhinitis immunotherapy using antigen-loaded multifunctional small extracellular vesicles
Wen Liu, Maki Ota, Yuki Takahashi, Yoshinobu Takakura.
- Development of a small extracellular vesicle (sEV) labeling method utilizing fusion protein of fluorescent proteins and sEV-tropic protein for the detection of phosphatidylserine status of sEVs
Yuki Kobayashi, Yuki Takahashi, Yoshinobu Takakura.
-
2019 擭
- International Society for Extracellular Vesicles 2019 (ISEV2019), (Kyoto, Japan), April 24-28 (2019)
- Development of CD40L-modified small extracellular vesicles for the effective
induction of anti-tumor immune response.
Wen L, Takahashi Y, Morishita M, Nishikawa M, Takakura Y.
- Development of Interferon 兞-loaded tumor cell-derived extracellular vesicles
applicable to cancer vaccine therapy.
Nakagawa N, Takahashi Y, Takakura Y.
2018
- Globalization of Pharmaceutics Education Network 2018 (GPEN2018), (Singapore), September 26-29 (2018)
- Development of Exosome Assembly Formed by Utilization of DNA Hybridization
and its Application for Cancer Vaccine.
Matsumoto A, Takahashi Y, Ariizumi R, Nishikawa M, Takakura Y.
- Development of A Nanostructured RNA/DNA Adjuvant Targeting Toll-like Receptor
7/8
Komura F, Nishikawa M, Takahashi Y, Takakura Y.
2017
- The 10th Seoul-Kyoto-Osaka Joint Symposium On Pharmaceutical Sciences For
Young Scientists, (Osaka, Japan), May 22-24 (2017)
- Development of exosome-based nucleic acid delivery systems.
Yamashita T, Takahashi Y, Nishikawa M, Takakura Y.
- 6th Annual Meeting of the International Society for Extracellular Vesicles
(ISEV), (Toronto, Canada), May 18-21 (2017)
- Yield, physicochemical properties, and pharmacokinetics of exosomes derived
from mouse cell lines.
Charoenviriyakul C, Takahashi Y, Morishita M, Matsumoto A, Nishikawa M, Takakura Y.
- Melanoma progression effects on biodistribution of B16BL6-derived exosomes from tumors and biological role of B16BL6-derived exosomes.
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y.
- International Symposium on Drug Delivery and Pharmaceutical Sciences: Beyond
the Histiry (ISDDPS), (Kyoto, Japan), March 9-10 (2017)
- Recent Advances in Nucleic acid Drug Delivery
Yoshinobu Takakura
2016
- Globalization of Pharmaceutics Education Network 2016 (GPEN2016), (Lawrence, KS, USA), November 9-12 (2016)
- Sustained expression system of interferon-beta by using interferon-inducible
Mx promoter for interferon-beta gene therapy.
Atsushi Hamana, Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura
(Short course: Challenges of Stabilizing Therapeutic Proteins)
- Elucidation of factors determining the cell distribution in artificially fabricated mixed multicellular spheroids for improved insulin secretion.
Yuya Mizukami, Makiya Nishikawa, Yuki Takahashi, Kazunori Shimizu, Satoshi
Konishi, Yoshinobu Takakura
- The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics, (Kyoto,
Japan), June 24-25 (2016)
- Role of phosphatidylserine-derived negative surface charge in the recognition
of B16BL6-derived exosomes by macrophages.
Akihiro Matsumoto, Yuki Takahashi, Makiya Nishikawa, Kohei Sano, Masaki
Morishita, Chonlada Charoenviriyakul, Hideo Saji, Yoshinobu Takakura.
Poster
Presentation Award
- Enhanced Activity of Immunosuppressive Oligodeoxynucleotides by Incorporating into Hexapod-like Nanostructured DNA.
Yuki Araie, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
- 5th Annual Meeting of the International Society for Extracellular Vesicles
(ISEV), (Rotterdam, the Netherlands), May 4-7 (2016)
- Induction of potent antitumor immune response by development of CpG DNA-conjugated
tumor cell-derived exosomes.
Morishita M, Takahashi Y, Nishikawa M, Takakura Y.
- Effect of exosome isolation methods on their yield, physicochemical and
pharmacokinetic properties.
Yamashita T, Takahashi Y, Nishikawa M, Takakura Y.
- University Bordeaux-Kyoto University Mini-Symposium on Biomolecular Science,
iCeMS, Kyoto University, (Kyoto, Japan), January 25 (2016)
- Polypod-like structured DNA for delivery of bioactive compounds.
Nishikawa M.
2015
- The Fourth International Meeting of The International Society for Extracellular
Vesicles 2015 (ISEV2015), (Washington, USA), April 23-26 (2015)
- Identification and screening of exosome-tropic RNA by Selex method
and its application in loading therapeutic RNA to exosomes.
Takahashi Y, Shinotsuka H, Kato K, Nishikawa M, Takakura Y.
- The 5th International Symposium on Carcinogenic Spiral Infection, Immunity,
and Cancer, (Kobe, Japan), February 26-27 (2015)
- Self-gelatinizable Nucleic Acid-based Sustained Delivery of Immunostimulatory
DNA and Antigen for Induction of Antitumor Immunity in Mice.
Umeki Y, Nishikawa M.
2014
- 10th Annual Meeting of the Oligonucleotide Therapeutics Society, (San Diego, USA), October 12-15 (2014)
- DNA Hydrogel-based Sustained Delivery of Immunostimulatory DNA and Antigen
for Induction of Antitumor Immunity in Mice.
Umeki Y, Nishikawa M, Mohri K, Takahashi Y, Takakura Y.
- Globalization of Pharmaceutics Education Network 2014 (GPEN2014), (Helsinki, Finland), August 27-30 (2014)
- Quantitative analysis of invivo fate of mouce melanoma B16BL6-derived exosomes
after intravenous injection into mice by development of labeling method
for exosomes.
Morishita M, Takahashi Y, Imai T, Nishikawa M, Takakura Y.
- Optimization of DNA nanostructure for delivery of nucleic acid drugs to
immune cells.
Ohtsuki S, Nishikawa M, Matsuzaki N, Mohri K, Endo M, Hidaka K, Sugiyama
H, Takahashi Y, Takakura Y.
(Short course: Nucleic acid and gene delivery section)
- The 8th Seoul-Kyoto-Osaka Joint Symposium On Pharmaceutical Sciences For
Young Scientists, (Osaka), June 10 (2014)
- Development of a quantitative and sensitive method to label exosomes for analysis of their in vivo fate.
Morishita M, Takahashi Y, Nishikawa M, Sano K, Saji H, Takakura Y.
- International Society for Extracellular Vesicles 2014, (Rotterdam), April
30-May 3 (2014)
- Quantitative analysis of the distribution and clearance of mouse melanoma
B16-BL6-derived exosomes in mice.
Takahashi Y, Imai T, Nishikawa M, Kato K, Morishita M, Takakura Y.
- 5th FIP Pharmaceutical Sciences World Congress, (Melbourne, Australia),
April 13-16 (2014)
- Quantitative evaluation of in vivo fate of mouse melanoma B16-BL6-derived
exosomes after intravenous injection into mice.
Takahashi Y, Imai T, Nishikawa M, Kato K, Morishita M, Takakura Y.
2013
- 9th Annual Meeting of the Oligonucleotide Therapeutics Society, (Naples,
Italy), October 6-8 (2013)
- Development of Self-Assembling and
Immunostimulatory Dendrimer-like DNA for Stimulation of Immune Cells.
Nishikawa M, Kusuki E, Mohri K, Endo M, Hidaka K,
Sugiyama H, Takahashi Y, Takakura Y
2012
- Globalization of Pharmaceutics Education Network 2012, (Melborne, Australia), November 28-December 1 (2012)
- Complete elimination of hepatitis C virus by sustained nonviral gene delivery
of human interferon 兞 in human hepatocyte chimeric mice.
M. Ando, Y. Takahashi, M. Nishikawa, N. Hiraga, M. Imamura,
K. Chayama, Y. Takakura
- 8th Annual Meeting of the Oligonucleotide Therapeutics Society (Boston,
USA), Oct 28-31 (2012)
- Visualization of Polypod-like Structured DNA, Polypodna, and Its Application as Nano-sized Immunomodulator and Building Block for Versatile DNA Hydrogel.
Makiya Nishikawa, Masayuki Endo, Hiroshi Sugiyama,
Yuki Takahashi, Yoshinobu Takakura
- American Society of Gene & Cell Therapy 15th Annual Meeting and Course
(Philadelphia, PA), May 16-19 (2012)
- Long-term elimination of human hepatitis C virus in human hepatocyte chimeric
mice after single administration of plasmid DNA expressing human interferon-兞.
Yuki Takahashi, Mitsuru Ando, Makiya Nishikawa,
Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama and Yoshinobu Takakura
2011
- 7th Annual Meeting of
the Oligonucleotide Therapeutics Society (Copenhagen, Denmark), September 8-10
(2011)
- Kinetic comparison of gene silencing profile of
siRNA and shRNA-expressing plasmid DNA in vivo.
Yuki Takahashi, Yuriko
Matsui, Makiya Nishikawa, Yoshinobu Takakura.
- Development of DNA nanogels and hydrogels as
injectable delivery systems for CpG DNA and other nucleic acid-based drugs.
Makiya Nishikawa, Kohta
Mohri, Kohei Ogawa, Natsuki Takahashi, Yuki Takahashi, Yoshinobu Takakura
丂
- 38th Annual Meeting and Exposition of the Controlled Release Society (National
Harbor, Maryland USA), July 30 - August 3 (2011)
- Optimization of interferon-兞 cancer gene therapy by
regulating transgene expression profile or controlling the tissue distribution
of transgene products.
Yoshinobu Takakura (Invited Speaker)
- The 6th
Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young
Scientists (Seoul, Korea), June 2-4 (2011)
- Enhancement of therapeutic effect of cell-based
therapy by increasing survival of transplanted cells using synthetic cell
adhesion molecules.
Kousuke Kusamori, Makiya Nishikawa, Tetsuya Suehara, Yuki Takahashi, Sayumi Yamazoe, Motonari Uesugi, Yoshinobu Takakura
丂
- American Society of Gene & Cell Therapy 14th Annual Meeting (Seattle WA, USA), May 18-21 (2011)
- Design and hydrodynamic gene transfer of 乪sticky乫 IFN兞 for liver-directed gene therapy.
Mitsuru Ando, Yuki
Takahashi, Hanae Mukumoto, Makiya Nishikawa, Yoshihiko Watanabe and Yoshinobu
Takakura.
2010
- Pharmaceutical Sciences World Congress 2010 (New Orleans, USA), November
14-18 (2010)
- Interferon 兞-mediated
inhibition of nuclear entry of plasmid vector and mRNA transcription from the
vector: an obstacle for repeated injections of interferon 兞-expressing plasmid vector
Lei Zang, Makiya Nishikawa, Kazuya
Machida, Mitsuru Ando, Yuki Takahashi, Yoshinobu Takakura.
- Design and gene delivery of mouse interferon 兞 genetically fused with mouse serum albumin
Noriko Miyakawa, Makiya Nishikawa, Yuki
Takahashi, Yoshihiko Watanabe, Yoshinobu Takakura
- Design and gene delivery of 乪sticky乫 interferon兞 to increase the
effect/side-effect ratio for liver-directed interferon-兞 gene therapy
Mitsuru Ando, Yuki Takahashi, Hanae
Mukumoto, Makiya Nishikawa, Yoshihiko Watanabe, Yoshinobu Takakura
丂丂
- Globalization of Pharmaceutics Education Network: Eighth Meeting, 2010
(GPEN2010), 丂丂丂丂丂(North丂Carolina,USA) November 10-12 (2010)
- Structural and immunological properties of polypod-like structure
forming nucleic acids
Kohta Mohri, Makiya Nishikawa, Nao
Matsuoka, Natsuki Takahashi, Yuki Takahashi, Yoshinobu Takakura.
- Acceleration of wound healing by increasing survival of transplanted
cells using adhsamine, a synthetic cell adhesion molecule
Kousuke Kusamori, Makiya Nishikawa, Tetsuya
Suehara, Yuki Takahashi, Sayumi Yamazoe, Motonari Uesugi, Yoshinobu Takakura
丂
- 6th Annual Meeting of
Oligonucleotide Therapeutics Society (Dana Point, USA) October 20-23 (2010)
- Pod number-dependent increase in the immunostimulatory activity of CpG
DNA formulated in polypod-like structures
Makiya Nishikawa, Kohta Mohri, Nao Matsuoka,
Kouhei Ogawa, Yuki Takahashi and Yoshinobu Takakura
丂
- American Society of Gene & Cell Therapy 13th Annual
Meeting (Washington DC, USA), May 19-22 (2010)
- Increased therapeutic effect of cell transplantation
for wound healing in diabetic mice by prolonging the survival of transplanted cells
using adhesamine, a synthetic adhesion molecule
Tetsuya Suehara, Makiya Nishikawa, Yuki Takahashi,
Sayumi Yamazoe, Motonari Uesugi, Yoshinobu Takakura.
- Prevention of atopic dermatitis by plasmid-based sustained transgene expression
of interferon 兞 in NC/Nga mice
Kayoko Hattori, Makiya Nishikawa, Kanitta
Watcharanurak, Akihiko Ikoma, Kenji Kabashima, Hiroyasu Toyota, Yuki Takahashi,
Rei Takahashi, Yoshihiko Watanabe, Yoshinobu Takakura
2009
- 36th Annual Meeting and Exposition of the Controlled Release Society (Copenhagen,
Denmark), July 18-22 (2009)
- Design and development of DNA-based nanoassemblies and hydrogels with enhanced immunostimulatory activity
Sakulrat Rattanakiat, Makiya Nishikawa, Yumiko Mizuno, Mitsuhiro Matono, Hisakage Funabashi, Dan Luo and Yoshinobu Takakura
2008
- Ehrlich II - 2nd World Conference on Magic Bullets, N?rnberg, (Germany), October 3-5 (2008)
- Interferon Gene Therapy against Metastatic Cancer
Yoshinobu Takakura, Makiya Nishikawa(invited)
- 2008 KCRS Annual Conference: Research Networking for Future Therapy, Jeju Island (Korea), September 4-5 (2008)
- Optimization of Design and Delivery of Plasmid Vector for Interferon Gene
Therapy
Yoshinobu Takakura(invited)
- American Society of Gene Therapy 11th Annual Meeting, Seattle (Boston,
MA), May 28- June 1 (2008)
- Reactivation of silenced transgene expression in mouse by rapid, large-volume
injection of isotonic solution
Makiya Nishikawa, Yuki Takahashi, Ayumi Nakayama, Yasushi Fukuhara, Yoshinobu
Takakura
- 2nd Asian Pacific Regional Meeting of International Society of Xenobiotics
(Shanghai, China), May 11-13 (2008)
- Receptor-mediated delivery of drugs, proteins and genes (tentative)
Makiya Nishikawa (Invited)
- The 4th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for
Young Scientists, (Kyoto), April 22-24 (2008)
- Unique property of IFN- production upon intravenous injection of CpG plasmid
DNA/cationic liposome complex
Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno, Hiroyasu
Toyota and Yoshinobu Takakura
- Pan-Pacific International Partnership Conference on Pharmaceutical and
Life Sciences (The 4th US-Japan Joint Conference) (Nagoya), Febrary 22-23 (2008)
- Nonviral gene delivery based on physical methods in combination with naked
plasmid DNA
Yoshinobu Takakura (Invited).
- Comparison of skin and spleen as injection site of vaccines for induction
of immune response
Xin Guan, Makiya Nishikawa, Yoshinobu Takakura
- Increasing anticancer activity of interferon gene transfer by prolonging
the duration of transgene expression
Lei Zang, Makiya Nishikawa, Masaru Mitsui, Yuki Takahashi, Yoshinobu Takakura
2007
- American Society of Gene Therapy 10th Annual Meeting, Seattle (USA), May
30- June 3 (2007)
- Inhibition of hepatic metastasis of colon carcinoma cells by RNA interference-mediated suppression of HIF-1兛 in tumor cells and hepatocytes
Yuki Takahashi, Makiya Nishikawa and Yoshinobu Takakura
- Deletion of CpG motifs from plasmid DNA for sustained transgene expression
in vivo: evaluation based on a statistical analysis of the expression profile
Makiya Nishikawa, Seiji Takemoto, Kiyoshi Yamaoka, Masaru Mitsui, Hisoon
Lee and Yoshinobu Takakura
- Heat shock protein 70-antigen fusion protein expressing DNA vaccin for cancer immunotherapy
Ayumi Yamaoka, Seiji Takemoto, Makiya Nishikawa, Tomoya Yata, yuji Ohno and Yoshinobu Takakura
- Pharmaceutical Sciences World Congress, Amsterdam (The Netherlands), April 22-25 (2007)
- Silencing of SOCS genes in cancer cells for effective interferon cancer
therapy
Yuki Takahashi, Makiya Nishikawa, Haruka Kaneda, Nana Takasuka, Kayoko
Hattori and Yoshinobu Takakura
- Young Pharmaceutical Scientists Meet in Amsterdam, Amsterdam (The Netherlands),
April 20-21 (2007)
- Inhibition of hepatic metastasis of colon carcinoma cells by RNA interference-mediated suppression of HIF-1兛 in tumor cells and hepatocytes
Yuki Takahashi, Makiya Nishikawa and Yoshinobu Takakura
- Conribution of macrophage-like cells to cytokine secretion after intravenous
injection of naked or complexed plasmid DNA
Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno and Yoshinobu
Takakura
- Formulation-dependent characteristics of cytokine secretion in primary
cultured cells and in mice stimulated with plasmid DNA
Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno and Yoshinobu
Takakura
2006
- Globalization of Pharmaceutics Education Network 2006, Kansas (USA), October
25-27 (2006)
- Enhanced CTL generation by HSP70 fusion protein harboring both MHC class
I and class II antigenic peptides
Seiji Takemoto, Makiya Nishikawa, Atsushi Ota and Yoshinobu Takakura
- Cytokine secretion profiles in primary cultured cells and in mice stimulated with plasmid DNA
Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda and Yoshinobu Takakura
- American Society of Gene Therapy 9th Annual Meeting, Baltimore (USA), May
31- June 4 (2006)
- Induction of antitumor immunity by cell-penetrating peptide-coupled Hsp70
gene transfer to tumor cells.
Takayuki Otsuki, Makiya Nishikawa, Atsushi Ota, Seiji Takemoto and Yoshinobu
Takakura
- Increased transgene expression of dystrophine in mdx muscle by RNAi-mediated silencing of calpain expression
Makiya Nishikawa, Kazuhiro Hirata, Kazuya Machida, Yuki Takahashi, Katsutoshi
Yuasa, Shinichi Takeda and Yoshinobu Takakura
- Enhancement of antitumor activity of interferons by RNAi-mediated silencing
of suppressors of cytokines signaling in tumor cells.
Yuki Takahashi, Haruka Kaneda, Makiya Nishikawa and Yoshinobu Takakura
2005
- 2nd Seoul-Osaka-Kyoto Joint Symposium on Pharmaceutical Sciences for young Scientists 2005, Osaka (Japan), December 4-6 (2005)
- Generation of cytotoxic T lymphocyte by delivery of MHC class I epitope
to antigen presenting cells using polyhistidine-coupled mouse heat shock
protein 70.
Seiji Takemoto, Makiya Nishikawa, Takayuki Otsuki, Ayumi Yamaoka, Kazuya
Maeda, Atsushi Ota and Yoshinobu Takakura
- 1st Indo-Japanese International Conference on Advances in Pharmaceutical
Research and Technology, Mumbai (India), November 25-29 (2005)
- Plasmid DNA delivery for in vivo cancer gene therapy.
Yoshinobu Takakura (Invited)
- 30th FEBS Congress & 9th IUBMB Conference, Budapest, (Hungary), July
2-7 (2005)
- Chemically modified catalase for prevention of ROS-mediated injury and tumor metastasis
Makiya Nishikawa
- 8th Annual Meeting of American Society of Gene Therapy, St. Louis, (USA), June 1-5 (2005)
- Enhanced anti-tumor effect of interferon gene transfer by sustained transgene expression using CpG-reduced plasmid DNA
Hiroki Kawano, Makiya Nishikawa, Masaru Mitsui and Yoshinobu Takakura
- Intratumoral delivery of small interfering RNA for inhibition of tumor progression in mice
Yuki Takahashi, Makiya Nishikawa and Yoshinobu Takakura
- 12th International Symposium of Recent Advances in Drug Delivery Systems, Salt Lake City (USA), Feb 21 - 24 (2005)
- Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes
Makiya Nishikawa, Yoshinobu Takakura, Mitsuru Hashida
- Biological responses to immunostimulatory DNA and its application for inhibition of peritoneal dissemination of tumor cells
Makiya Nishikawa, Yukari Umeyama, Keiko Kako, Mitsuru Hashida and Yoshinobu Takakura
- Development of heat shock protein 70-based tumor vaccine: pharmacokinetic considerations and antigen delivery.
Seiji Takemoto, Takayuki Otsuki, Ayumi Yamaoka, Makiya Nishikawa and Yoshinobu Takakura
2004
- 2nd World Congress of the Board of Pharaceutical Sciences of FIP (PSWC2004), Kyoto (Japan) 30 May - 3 June (2004)
- Increased dendritic cell migration to the vaccination site and enhanced
immune response by polyplex-based DNA vaccine
Atsushi Kawase, Ayumi Yamaoka, Makiya Nishikawa and Yoshinobu Takakura
- Involvement of scavenger receptor and clathrin-mediated endocytosis in plasmid DNA uptake by mouse macrophages and dendritic cells
Takaharu Yoshinaga, Haruka Kaneda, Yoshiyuki Ogawa, Makiya Nishikawa and Yoshinobu Takakura
- Reduced DNA uptake and degradation in antigen-presenting cells from systemic lupus erythematosus model mice
Yoshiyuki Ogawa, Takaharu Yoshinaga, Makiya Nishikawa and Yoshinobu Takakura
- Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen
Tomoko Ikenaga, Makiya Nishikawa and Yoshinobu Takakura
- Control of intracellular trafficking of genetically delivered antigens in dendritic cells for improved DNA vaccination
Keiko Isaji, Makiya Nishikawa, Atsushi Kawase, Ayumi Yamaoka and Yoshinobu Takakura
- Acute inflammatory response to nonviral vectors in mice is mediated by antigen presenting cells
Keiko Kako, Makiya Nishikawa and Yoshinobu Takakura
- Therapeutic effects of interferon gene delivery by CpG-reduced plasmid DNA
Hiroki Kawano, Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura
- Gene silencing in primary and metastatic tumors by siRNA-expressing vector
Yuki Takahashi, Makiya Nishikawa, Naoki Kobayashi, Makoto Miyagishi*, Kazunari Taira* and Yoshinobu Takakura (*Graduate School of Engin. Univ. of Tokyo.)
- Uptake of plasmid DNA and subsequent cellular activation in human macrophages
Yuga Fukuhara, Ikuko Yamane, Takaharu Yoshinaga, Makiya Nishikawa and Yoshinobu Takakura
- Tissue distribution characteristics of mouse heat shock protein 70, a possible immune activator for tumor therapy
Takayuki Otsuki, Seiji Takemoto, Makiya Nishikawa and Yoshinobu Takakura
- Effects of cholesterol depletion on secretion polarity of human interferon-
b in Mardin-Darby canine kidney cells
Kayo Ishida, Masato Maruyama, Yoshihiko Watanabe and Yoshinobu Takakura
- Hydrodynamics-based efficient intracellular gene delivery involves a nonspecific
process via the hepatic cellular membrane of transient hyperpermeability
Kazuhiro Hirata, Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura
- Vector-based in vivo RNA interference targeting exogenous and endogenous
genes
Hiroyuki Yoshida, Naoki Kobayashi, Yumi Matsui, Kazuhiro Hirata, Makoto Miyagishi*, Kazunari Taira*, Makiya Nishikawa and Yoshinobu Takakura (*Graduate School of Engin. Univ. of Tokyo.)
- 5th Globalization of Pharmaceutics Education Network (GPEN) International Graduates Student Meeting, Kyoto (Japan), May 26-28 (2004)
- In vivo manipulation of dendritic cell migration and activation to elicit
immune response by polyplex-based DNA vaccination
Atsushi Kawase, Ayumi Yamaoka, Makiya Nishikawa and Yoshinobu Takakura
- Mechanism of plasmid DNA uptake by mouse macrophages and dendritic cells
Takaharu Yoshinaga, Haruka Kaneda, Yoshiyuki Ogawa, Makiya Nishikawa and Yoshinobu Takakura
- Pathognomonic DNA Processing in Antigen-Presenting Cells from Lupus-Prone NZB x NZW F
1
Mice
Yoshiyuki Ogawa, Takaharu Yoshinaga, Makiya Nishikawa and Yoshinobu Takakura
- Tissue distribution characteristics of mouse heat shock protein 70; CD91 is the main uptake receptor in the liver
Seiji Takemoto, Takayuki Otsuki, Makiya Nishikawa and Yoshinobu Takakura
- Improved antigen presentation efficiency by dendritic cells with plasmid DNA encoding structure-modified antigens
Keiko Isaji, Makiya Nishikawa, Atsushi Kawase, Ayumi Yamaoka and yoshinobu Takakura
- Contribution of macrophages to the acute inflammatory responses following nonviral vector administration
Keiko Kako, Makiya Nishikawa and Yoshinobu Takakura
- Antitumor activities of interferon gene delivery by CpG-reduced plasmid
DNA in murine metastasis models
Hiroki Kawano, Makiya Nishikawa and Yoshinobu Takakura
- Delivery of siRNA and siRNA-expressing vector to primary and metastatic tumors for induction of in vivo RNA interference
Yuki Takahashi, Makiya Nishikawa, Naoki Kobayashi, Makoto Miyagishi, Kazunari Taira and Yoshinobu Takakura
- CpG-motif independent activation of human macrophages derived from peripheral
blood mononuclear cells by DNA/cationic liposome
Yuga Fukuhara, Ikuko Yamane, Takaharu Yoshinaga, Makiya Nishikawa and Yoshinobu Takakura
- Mechanism of Polarized Secretion Erythropoietin in Mardin-Darby Canine Kidney Cells
Kayo Ishida, Masato Maruyama, Yoshihiko Watanabe and Yoshinobu Takakura
- Mechanism of Plasmid DNA Delivery by Hydrodynamics-Based Procedure
Kazuhiro Hirata, Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura
- Sequence-specific suppression of the expression of exogenous and endogenous genes in mice via RNA interference
Hiroyuki Yoshida, Naoki Kobayashi, Yumi Matsui, Kazuhiro Hirata, Makoto Miyagishi, Kazanari Taira, Makiya Nishikawa and Yoshinobu Takakura
2002
- 4th Globalization of Pharmaceutics Education Network (GPEN) International Graduates Student Meeting, Michigan (USA), November 6-8 (2002)
- Plasmid DNA Uptake and Subsequent Induction of Inflammatory Cytokines in Cultured Mouse Macrophages
Kei Yasuda, Hiroki Kawano and Yoshinobu Takakura
- Analysis of Secretion Polarity after Gene Delivery to Epithelial Cells
Masato Maruyama, Yoshihiko Watanabe and Yoshinobu Takakura
- Characterizaton of Hepatic Delivery of Macromolecules with Large Volume Injection and its Therapeutic Application
Naoki Kobayashi, Atsushi Kawase and Yoshinobu Takakura
- 29th Annual Meeting and Exposition of the Controlled Release Society, Seoul (Korea), July 20-25 (2002)
- DNA Complexed with Cationic Liposomes Induces Inflammatory Cytokines from Cultured Mouse Macrophages
Kei Yasuda, Yoshiyuki Ogawa, Michiyuki Kishimoto, Yasufumi Kaneda, Mitsuru Hashida and Yoshinobu Takakura
- Induction of Antigen-specific Immune Responses Based on Chemical Modification of Antigen Proteins Targeting to Antigen Presenting Cells
Yasuomi Yamasaki, Tomoko Ikenaga and Yoshinobu Takakura
- Characterization of the Hydrodynamics-based Hepatic Delivery of Macromolecules
Naoki Kobayashi, Shi Chen, Kiyoshi Yamaoka and Yoshinobu Takakura
- Secretion Polarity and Intracellular Transport of Interferon-GFP Fusion Protein after Gene Delivery to Epithelial Cells
Masato Maruyama, Toyokazu Yoshida, Yoshihiko Watanabe and Yoshinobu Takakura
- Control of Disposition Characteristics of Plasmid DNA after Local Administration by Complexation with Cationic Macromolecules
Atsushi Kawase, Naoki Kobayashi, Kiyoshi Yamaoka and Yoshinobu Takakura
- Secretion Polarity after Erythropoietin Gene Transfer in Epithelial cells is Dependent on Gene Expression Mode
Michiyuki Kishimoto, Yoshihiko Watanabe and Yoshinobu Takakura
- Plasmid DNA Uptake and Subsequent Immune Responses in Dendritic Cells
Takaharu Yoshinaga, Kei Yasuda and Yoshinobu Takakura
2000
- Millennial World Congress of Pharmaceutical Sciences, San Francisco (USA) 16-20 April (2000)
- Plasmid DNA Uptake and Subsequent Activation in Cultured Mouse Peritoneal Macrophages
Kei Yasuda, Miho Ueno, Aki Murao, Toshihide Takagi, Mitsuru Hashida, and Yoshinobu Takakura
- Effects of Molecular Weight and Number of Negative Charges on Pharmacokinetics of Succinylated Proteins
Yasuomi Yamasaki, Kazuya Sumimoto, Makiya Nishikawa, Fumiyoshi Yamashita, Kiyoshi Yamaoka, Mitsuru Hashida, and Yoshinobu Takakura
- Characteristics of Hepatic Uptake of Plasmid DNA Related to Gene Expression and Immune Responses
Naoki Kobayashi, Kiyoshi Yamaoka, Mitsuru Hashida, and Yoshinobu Takakura
- Polarized Secretion of IFN- b in Epithelial Cells Following Gene Transfer
with IFN- b Encoding Plasmid
Masato Maruyama, Kiyo Nakanishi, Yoshihiko Watanabe, Mitsuru Hashida, and Yoshinobu Takakura
1999
- Strategies for Optimizing Oral Drug Delivery: Scientific to Regulatory Approaches, Kobe (Japan) 19-21 April (1999)
- Transport Characteristics of a CYP3A4 Substrate Across Human Intestinal Caco-2 Cell Monolayers
Yukiko Akazawa, Yuuichiro Imamura, Kazuteru Shimizu, Fumiyoshi Yamashita, Kiyoshi Yamaoka, Mitsuru Hashida and Yoshinobu Takakura
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