Theses
2022
Doctoral Theses
- Development of nucleic acid therapeutics based on the control of intracellular distribution
Keisuke UMEMURA
- Development of macrophage-targeted therapy using peptide/protein-loaded extracellular vesicles
Misako TAKENAKA
Masters Theses
- The Correlation between the Structural Characteristics of DNA nanotube and Cellular Uptake Selectivity
Kento YASUI
Theses (Undergraduate students)
- Development of functionalized DNA containing i-motifs that induces sustained immunoactivity of CpG DNA
Wakana ODA
- Development of anti-inflammatory therapy using microspheres that enable sustained-release of small extracellular vesicles
Maki OTA
- Analysis of behavior of intranasally administered NOZOsmall extracellular vesicles in the brain
Nozomi OTAKE
2021
Masters Theses
- Development of the Selective and Scalable Methods for the Preparation of Small Extracellular Vesicles with Long Blood-circulation Half-life
Shimpei KITAMURA
- Development of Transfection Method Using Sonoporation Caused by Gas Vesicles and Ultrasound
Takuma KOBOYA
Theses (Undergraduate students)
- Development of Gelatin Methacrylate Microspheres for Sustained Release of Small Extracellular Vesicles
Miki SHIONO
- Investigation of in vivo behavior of extracellular vesicles with different sizes after administration into gastrointestinal tract
Momoko NAIKI
- Involvement of Collagen in Cell Type-Specific Uptake of DNA Nanotube
Koki MAEDA
- Development of a method to detect phosphatidylserine-positive small extracellular vesicles using a fusion protein of sEV-tropic protein and fluorescent protein
Ayane YABUTA
Doctoral Theses
- Rolling Circle Amplification (RCA)により調製される長鎖一本鎖DNA(lss-DNA)を利用した核酸構造体のドラッグデリバリーシステムへの応用に関する研究
Koichi ITO
- Implementation of highly sensitive small extracellular vesicle (sEV) quantification method in the identification of novel sEV production modulators and the evaluation of sEV pharmacokinetics
Aki YAMAMOTO
- Development of Immunotherapy Using Antigen-loaded Multifunctional Small Extracellular Vesicles.
Wen LIU
2020
Masters Theses
- Elucidation of the roles of small extracellular vesicles in disease progression after hepatitis C virus elimination
Yuya TAKAMI
- Identification of Long-Circulating Extracellular Particles and Analysis of Their Pharmacokinetics
Asahi YOSHIDA
-
Theses (Undergraduate students)
- 樹状細胞由来細胞外小胞を利用した効果的ながんワクチン療法の開発
Maho ASUKA
- CpG DNAの免疫細胞への効率的なデリバリーキャリアとしてのヘアピン構造を有するDNAリングの開発
Kana OKUZUMI
- RNAナノテクノロジーを利用した細胞外小胞搭載のためのRNA多量体の開発
Ayako MIYAKE
- Gas Vesicle(GV)の調製法の最適化とその体内動態評価
Takuma YAMAGUCHI
2019
Doctoral Theses
- 高機能細胞スフェロイド開発を目的としたスフェロイド微小環境制御に関する研究
Yuya MIZUKAMI
- Development of Small Extracellular Vesicle-Based Therapeutics Based on
the Elucidation and Regulation of Pharmacokinetics Properties (細胞外小胞の体内動態特性の解明とその制御に基づく疾患治療法の開発に関する研究)
Akihiro MATSUMOTO
- RNAを認識するToll様レセプターを標的としたナノ構造化RNAアジュバントの開発に関する研究
Fusae KOMURA
- Structural optimization of polypod-like structured DNA based on structural analysis and interaction with cells（構造解析および細胞との相互作用解析に基づく多足型DNA構造体の構造最適化に関する研究）
Mengmeng TAN
- Development of Nanostructured DNA Aimed at Enhancing the Stability and Antigen-presenting Cell Targetability of CpG Oligodeoxynucleotide
(CpGオリゴデオキシヌクレオチドの安定性および抗原提示細胞指向化の増強を目指したナノ構造化DNAの開発)
Wenqing LIAO
Masters Theses
- 細胞外小胞を利用したマクロファージへのIL-4デリバリーによる抗炎症治療法の開発
Misako TAKENAKA
- Development of the delivery carrier for CpG DNA to immune cells by using
long-single stranded-DNA prepared by rolling circular amplification (ローリングサークル増幅により調製した長鎖一本鎖DNAを用いた免疫細胞へのCpG
DNAのデリバリーキャリアの開発)
Pengyu WEI
Theses (Undergraduate students)
- Development of hydrophobic interaction based DNA supramolecules as co-delivery
carrier of CpG DNA and antigen protein to immune cells.
Mutsumi KARIYA
- Assembling Small Extracellular Vesicles with Long Single Stranded DNA for
Enhancing Antitumor Immunity of Tumor Cell-Derived sEVs.
Akari SUZUKI
- Evaluation of effect of enzymatic deglycosylation treatment on pharmacokinetics
of small extracellular vesicles.
Yukari YASUE
2018
Doctoral Theses
- RNAデリバリーを目的としたエキソソームの調製法に関する研究
Takuma YAMASHITA
- Evaluation of the pharmacokinetic and pharmaceutical characteristics of
exosomes for the development of exosome-based drug delivery carrier.
Chonlada CHAROENVIRIYAKUL
-
Masters Theses
- Development of an efficient loading method of RNA into exosomes by utilizing
RNA-binding protein.
- Reiichi ARIIZUMI
- Development of CD40L-modified exosomes for the effective induction of anti-tumor
immune response.
- Wen LIU
Theses (Undergraduate students)
- Effects of localization of antigen proteins in antigen-loaded exosomes
on antigen presentation efficiency.
- Yuta ARIMA
- Decoding the Contribution of Macrophage Scavenger Receptor 1 to the Cellular
Uptake of Polypod-like Nanostructured DNA.
- Keisuke UMEMURA
- Enhanced angiogenesis by combined use of adipose tissue-derived stem cell
spheroids and carbocyclic oxetanocin A.
- Shunsuke NISHIMURA
- Elucidation of structural properties of DNA origami-based DNA nanostructures
suitable for delivery to immune cells.
- Tatsuoki MAEZAWA
2017
Doctoral Theses
- 多足型DNAナノ構造体を利用した核酸医薬の標的指向化および体内動態制御に関する研究
Yousuke TAKAHASHI
- Elucidation and Optimization of the Interaction of Nanostructured DNA and Immune Cells.
Shozo OHTSUKI
- Development of a promising interferon gene therapy strategy by vector design.
Atsushi HAMANA
Masters Theses
- Enhancement of tumor cell vaccine effectiveness by combination of cationic polymer-modified tumor cells and CpG DNA hydrogel.
- Masaaki SAITO
Theses (Undergraduate students)
- Combined use of chemically modified nucleobases and nanostructured DNA
for enhanced immunostimulatory activity of CpG oligodeoxy nucleotide.
- Yuki ARAIE
- Regulation of interferon-β bioactivity by utilization of blue light receptor
VIVID.
- Akane TANIOKA
- Development of efficient exosome collection method by optimization of culture
medium volume.
- Shota HATTORI
- Fabrication of cell spheroids with high mechanical strength by using methylcellulose.
- Ai MORIYA
-
2016
Doctoral Theses
- 免疫活性化DNAハイドロゲルを利用した抗原デリバリーシステムの開発に関する研究
Yuka UMEKI
- 細胞を利用した疾患治療・病態解析を目的とした高機能化細胞スフェロイドの開発に関する研究
Yutaro TANAKA
- 癌細胞由来エキソソームを利用した癌抗原デリバリーシステムに基づく癌免疫療法の開発に関する研究
Masaki MORISHITA
Masters Theses
- Orientation of Oligodeoxynucleotides in Polypod-like Structured DNA elucidated
by Atomic Force Microscopy
- Mengmeng TAN
- Evaluation on involvement of phosphatidylserine-derived negative surface
charge in the uptake of exosomes byu macrophages
- Akihiro MATSUMOTO
Theses (Undergraduate students)
- Combination of spheroid formation and carbocyclic oxetanocin A for the
upregulation of vascular endothelial growth factor expression in adipose
tissue-derived stem cells.
- Yuka OGINO
- Elucidation of the relationship between the structural properties and cellular
uptake of DNA origami-based DNA nanostructures.
- Yukako SHIBA
- Development of DNA supramolecules formed by hydrophobic interaction for
the effective delivery of CpG DNA.
- Kanako SUGIMURA
-
2015
Doctoral Theses
- .Development of immunostimulatory motif-containinng DNA-based delivery system
for drugs and antigens.
Yumiko MIZUNO
- .Development of efficient amplification method of DNA hydrogel and composite-type
DNA hydrogel for photothermal immunotherapy.
Tomoya YATA
Masters Theses
- .Evaluation of physicochemical properties and pharmacokinetics of exosomes
derived from different types of cells.
Chonlada CHAROENVIRIYAKUL
- .Sustained activation of vaginal mucosal immunity by DNA hydrogel-assisted
intravaginal administration of CpG DNA
Daiki NOMURA
Theses (Undergraduate students)
- .Development of adjuvant-loaded magnesium pyrophosphate sponge-like microparticles
for effective induction of immune responses.
Shoichi TAKAGI
- .Gene delivery of fibrin clot-binding peptide-interferon-γ fusion protein
for effective interferon-γ cancer gene therapy.
Mai FUJIMOTO
- .Elucidation of factors determining the cell distribution and function
in artificially fabricated mixed multicellular spheroids.
Yuya MIZUKAMI
2014
Doctoral Theses
- .Analysis of transgene expression profile-dependent induction of transgene-specific
immune response.
YaLei YIN
Masters Theses
Theses (Undergraduate students)
- .Correlation analysis of the relationship between the pod number-dependent
structural properties in aqueous solution and cellular uptake of polypod-like
structured DNA.
Tomoki SHIOMI
- .SELEX-based identification of exosome-tropic RNA and its application in
loading therapeutic RNA to exosomes.
Haruka SHINOTSUKA
- .Evaluation of the effect of exosome isolation methods on characteristics of exosomes.
Takuma YAMASHITA
2013
Doctoral Theses
Masters Theses
Theses (Undergraduate students)
2012
Doctoral Theses
Masters Theses
- .ポリ- N -イソプロピルアクリルアミド被覆ポリジメチルシロキサン製基板を利用した細胞
スフェロイド調製法の開発と細胞治療への応用．
舛澤 暁
- .Development of interferon g fusion proteins with improved blood retention property and retained biological activity．
Masayuki MISAKA
- .Stable overexpression of STING induces spontaneous IFN production in C1300
cells.
岡田佳恵
Theses (Undergraduate students)
-
Cellular Uptake Mechanism of Fluorescently Labeled Exosomes.
Saori OHARA
-
Optimization of the Structure of Tetrapodna for Cellular Uptake and Immunostimulation.
Natsuki TAKAHASHI
-
Design and Comparison of Self-assembled DNA Nanostructures with Different Stereoscopic Properties.
Noriyuki MATSUZAKI
2011年度
博士論文
修士論文
特別実習卒業論文
2010 年度
博士論文
- 有効なインターフェロン遺伝子治療のための体内動態改善型インターフェロン融合タンパク質の設計と遺伝子デリバリーに関する研究
宮川典子
- Optimization of interferon γ gene delivery/expression system
towards realization of interferon γ gene
therapy
Lei Zang
修士論文
- Effect of sustained interferon-γ gene expression on atopic and contact dermatitis in mice
Kanitta Watcharanurak
- Enhancement
of anticancer effect of interferon-γ
gene therapy by depletion of tumor-associated macrophages
Tsuyoshi Kiyota
-
Inhibition of surgical
trauma-enhanced peritoneal dissemination by human catalase derivatives
Chika Nishizaki
-
Interleukin-6 gene delivery to
skeletal muscle for improvement of insulin resistance
Hanae Mukumoto
-
Mechanism of osmotic pressure-induced increase in transgene expression
for the development of reactivation system for gene expression
Shinji Yoshinaga
2009 年度
博士論文
- Development of novel DNA-based nanosized drug delivery system using DNA
containing unmethylated CpG dinucleotides
Sakulrat Rattanakiat
- Development of DNA vaccine-based anti-tumor immunotherapeutic system
Xin Guan
修士論文
- Control of spatiotemporal distribution of IFN-γfor optimization of IFN-γgene
therapy
Mitsuru Ando
- Acceleration of wound healing by
increasing survival of transplanted cells using adhesamine, a synthetic cell
adhesion molecule
Tetsuya
Suehara
- Role of inflammatory cytokines and reactive oxygen
species on reactivation of transgene expression
Naomi Takiguchi
- Improved dermal delivery of CpG oligodeoxynucleotides by cholesterol modification for the treatment of atopic
dermatitis
Hiroyasu Toyota
- Development and evaluation of polypodna,a polypod-like structure forming nucleic acid
Nao Matsuoka
2008 年度
博士論文
- Analysis of production profiles of inflammatory cytokine and type I interferon induced by plasmid DNA in cultured cells and in mice
Hiroyuki Yoshida
修士論文
- Design and development of liposomal DDS for renal delivery of CK2 inhibitor
Nana Takasuka
- Sustaining transgene expression of murine interferon γ for the treatment
of atopic dermatitis
Kayoko Hattori
- Effect of cytoskeleton changes induced by physical gene transfer on transgene expression
Yasushi Fukuhara
- Development of short DNA-based nanoparticles and hydrogels for immuno- and chemotherapy
Yumiko Mizuno
- Development of cytophilic human catalase for control of abnormal cell adhesion
Tomoya Yata
2007 年度
博士論文
- Development of novel cancer therapy strategies based on small interfering
RNA delivery
Yuki Takahashi
修士論文
- Increased antitumor immunity of heat shock protein 70 by conjugating cell-penetrating
peptide
Atsushi Ota
- Regulation of transgene expression in interferon gene therapy
Kazuya Machida
- Cytokine induction by non-CpG plasmid DNA/liposome complex in macrophages
Sachiyo Yasuda
- Factors affecting the expression of antigens following DNA vaccination
Lee Hisoon
2006 年度
博士論文
- Heat shock protein 70 を利用した抗腫瘍免疫システムの開発に関する研究
竹本 誠二
修士論文
- Delivery of DNA-based chemo- and immunotherapeutic system to tumor-macrophage
interface for effective cancer therapy
Tomoyuki
Naoi
- Increased transgene expression by biological responses dependent on in
vivo gene transfer method
Ayumi
Nakayama
- Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape
formation
Mitsuhiro
Matono
- Persistent interferon gene expression by plasmid design for cancer therapy
Masaru
Mitsui
2005 年度
博士論文
- 全身性エリテマトーデスモデルマウスにおけるDNA処理特性に関する研究
小川 芳之
修士論文
- Control of secretion polarity of exogenously expressed interferon in epithelial
cells
Kayo
Ishida
- Induction of anti-tumor immunity by cell-penetrating peptide-fused Hsp70
gene transfer to tumor cells
Takayuki Otsuki
- Enhancement of anti-tumor activity of interferons by RNA interference-mediated silencing of SOCS expression
Haruka
Kaneda
- Improved transgene expression of dystrophin by RNA interference-mediated
silencing of calpain expression
Kazuhiro
Hirata
- Development of multifunctional DNA vaccine based on heat shock protein 70
Ayumi
Yamaoka
- Cellular activation of macrophages in primary culture by plasmid DNA
Hiroyuki Yoshida
2004 年度
博士論文
- DNA ワクチンの最適化を目指したプラスミド DNA および樹状細胞の動態解析と免疫応答の制御に関する研究
川瀬 篤史
- マウス樹状細胞におけるプラスミド DNA の取り込みおよびその後の活性化機構に関する研究
吉永 貴治
修士論文
- Design of plasmid DNA encoding antigen with controlled intracellular trafficking
properties for dendritic cell-targeted DNA vaccination
Keiko Isaji
- Effects of inflammatory responses on in vivo transgene expression following
nonviral vector administration
Keiko Kako
- Persistent Transgene Expression by CpG Reduction in Plasmid DNA and Enhanced Therapeutic Effect of Interferon Gene Therapy
Hiroki Kawano
- Induction of in vivo RNA interference and its application to cancer gene
therapy
Yuki Takahashi
- Analysis of plasmid DNA uptake mechanism and subsequent cellular activation through TLR9-independent pathway in human monocyte-derived cells in primary culture
Yuga Fukuhara
2003 年度
博士論文
- In Vivo Plasmid DNA Delivery based on Large-Volume Intravenous Injection
Naoki Kobayashi
- 極性を有する上皮細胞へのインターフェロン遺伝子導入後の分泌方向性に関する研究
丸山 正人
修士論文
- Cationization of Antigen Protein for Delivery to Antigen-presenting Cells and Enhancement of Immune Response
Tomoko Ikenaga
- Tissue distribution characteristics of mouse heat shick protein 70, a possible immune activation for tumor therapy
Seiji Takemoto
- Secretion polarity of expressed protein following in vivo gene delivery
to mice hepatocytes
Shi Chen
- Sequence-specific Supression of mdr1a/1b Expression in Mice via RNA Interference
Yumi Matsui
- Plasmid DNA Uptake and Subsequent Cellular Activation in Cultured Human
Macrophages
Ikuko Yamane
- Control of Secretion Polarity of Exogenously Expressed Interferon in Epithelial Cells
Toyokazu Yoshida
2002 年度
博士論文
- Plasmid DNA Uptake and Subsequent Cellular Activation Mechanisms in Cultured Mouse Macrophages
Kei yasuda
- 化学修飾を利用したタンパク質の抗原提示細胞への選択的デリバリーと特異的免疫応答の誘導に関する研究
山崎 泰臣
修士論文
- DNA Uptake and Subsequent Cellular Activation in Antigen-Presenting Cells from Lupus-Prone Mice
Yoshiyuki Ogawa
- Novel Evaluation Method for Nonlinear Local Drug Distribution (in loci) in Intestine, Liver and Kidney
Takako Kato
- Chemical Modification of Antigen Protein for Efficient Uptake and MHC Class I Presentation by Antigen Presenting Cells
Kohsuke Shakushiro
- Analysis of Secretion Polarity and Intracellular Transport of Interferon in Renal Epithelial LLC-PK1 Cells
Teruko Nishio
- Uptake Mechanism of Plasmid DNA in Liver Sinusoidal Endothelical Cells
Jin Hisazumi
2001 年度
修士論文
- Effect of Interferons of on P-glycoprotein Expression and Its Function as Drug Efflux Transporter
Hiroko Kawaguchi
- Characterization of Plasmid DNA Disposition and Gene Expression Following Local Administration for Optimization of DNA Vaccination
Atsushi Kawase
- Secretion Polarity Mechanism after Erythropoietin Gene Transfer in Epithelial Cells
Michiyuki Kishimoto
- Mechanism of Plasmid DNA Uptake and Subsequent Activation in Dendritic
Cells
Takaharu Yoshinaga
2000 年度
修士論文
- In Vivo Disposition Characteristics and Gene Expression Following Intravenous Administration of Plasmid DNA
Naoki Kobayashi
- Characterization of Intestinal Permeability of a Second- generation Antisense Oligonucleotide
Kazuteru Shimizu
- Analysis of Secretion Polarity after Interferon Gene Delivery to Polarized Epithelial Cells
Masato Maruyama
1999 年度
修士論文
- Effects of Interferons on P-glycoprotein-mediated Drug Efflux in Human Intestinal Caco-2 Cells and Rat hepatocytes
Yukiko Akazawa
- Mechanisms of Plasmid DNA Uptake and Subsequent Immune Responses in Macrophages
Kei Yasuda
- Pharmacokinetic Analysis of In Vivo Disposition of Succinilated Proteins Targeted to Liver nonparenchymal Cells
Yasuomi Yamasaki
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