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Original research articles from this laboratory / Akiba’s publication

2021

• Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support
  Ito T, Minamitani T, Hayakawa M, Otsubo R, Akiba H, Tsumoto K, Matsumoto M, Yasui T
  Sci. Rep. 11, 22341 (2021).
  https://doi.org/10.1038/s41598-021-01696-3
  

• Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing
  Akiba H, Ise T, Nagata S, Kamada H, Ohno H, Tsumoto K
  Sci. Rep. 11, 19411 (2021).
  https://doi.org/10.1038/s41598-021-98855-3
  

• Epitope-dependent thermodynamic signature of single-domain antibodies against hen egg lysozyme
  Akiba H, Tamura H, Caaveiro JMM, Tsumoto K
  J. Biochem. accepted.
  https://doi.org/10.1093/jb/mvab082
  

• Novel neutralizing human monoclonal antibodies against tetanus neurotoxin
  Minamitani T, Kiyose K, Otsubo R, Ito T, Akiba H, Furuta RA, Inoue T, Tsumoto K, Satake M, Yasui T
  Sci. Rep. 11, 12134 (2021).
  https://doi.org/10.1038/s41598-021-91597-2
  

2020

• The Kg-antigen, RhAG with a Lys164Gln mutation, gives rise to haemolytic disease of the newborn
  Tanaka M, Abe T, Minamitani T, Akiba H, Horikawa T, Tobita R, Isa K, Ogasawara K, Takahashi H, Tateyama H, Tone S, Tsumoto K, Yasui T, Kimura T, Fujimura Y, Hirayama F, Tani Y, Takihara Y
  Br. J. Haematol. 191, 920-926 (2020).
  https://doi.org/10.1111/bjh.16955
  
• Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain
  Xie J, Gonzalez-Carter D, Tockary TA, Nakamura N, Xue Y, Nakakido M, Akiba H, Dirisala A, Liu X, Toh K, Yang T, Wang Z, Fukushima S, Li J, Quader S, Tsumoto K, Yokota T, Anraku Y, Kataoka K
  ACS Nano, 14, 6729-6742 (2020).
  https://doi.org/10.1021/acsnano.9b09991
  
• ⁶⁴Cu-labeled minibody D2101 visualizes CDH17-positive gastric cancer xenografts with short waiting time
  Fujiwara K, Akiba H, Tsuji AB, Sudo H, Sugyo A, Nagatsu K, Zhang MR, Iwanari H, Kusano-Arai O, Kudo S, Kikuchi C, Tsumoto K, Momose T, Hamakubo T, Higashi T
  Nucl. Med. Commun. 41, 688-695 (2020).
  https://doi.org/10.1097/mnm.0000000000001203
• GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab
  Kato D, Yaguchi T, Iwata T, Katoh Y, Morii K, Tsubota K, Takise Y, Tamiya M, Kamada H, Akiba H, Tsumoto K, Serada S, Naka T, Nishimura R, Nakagawa T, Kawakami Y
  eLife 9, e49392 (2020).
  https://doi.org/10.7554/eLife.49392
• Computer-guided library generation applied to the optimization of single-domain antibodies
  Akiba H, Tamura H, Caaveiro JMM, Tsumoto K
  Prot. Eng. Des. Selec. 32, 423-431 (2020)
  https://doi.org/10.1038/s41598-019-50722-y
• Generation of biparatopic antibody through two-step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher
  Akiba H, Takayanagi K, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K
  Biotechnol. Rep. 25, e00418 (2020)
  https://doi.org/10.1016/j.btre.2020.e00418

2019

• ¹¹¹In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis.
  Fujiwara K, Tsuji AB, Sudo H, Sugyo A, Akiba H, Iwanari H, Kusano-Arai O, Tsumoto K, Momose T, Hamakubo T, Higashi T
  Ann. Nucl. Med. 34, 13-23 (2019)
  https://doi.org/10.1007/s12149-019-01408-y
• Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody.
  Akiba H, Tamura H, Kiyoshi M, Yanaka S, Sugase K, Caaveiro JMM, Tsumoto K
  Sci. Rep. 9, 15481 (2019)
  https://doi.org/10.1038/s41598-019-50722-y
• Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design
  Akiba H, Satoh R, Nagata S, Tsumoto K
  Antib. Ther. 2, 65-69 (2019)
  https://doi.org/10.1093/abt/tbz008
  Cover Image of the issue (https://academic.oup.com/abt/issue/2/3)

2018

• Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody.
  Akiba H, Ikeuchi E, Ganbat J, Fujikawa H, Arai-Kusano O, Iwanari H, Nakakido M, Hamakubo T, Shimomura Y, Tsumoto K
  J. Struct. Biol. 204, 207-214 (2018)
  https://doi.org/10.1016/j.jsb.2018.08.011
• Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody.
  Miyanabe K, Akiba H, Kuroda D, Nakakido M, Kusano-Arai O, Iwanari H, Hamakubo T, Caaveiro JMM, Tsumoto K
  J. Biochem. 164, 65-76 (2018)
  https://doi.org/10.1093/jb/mvy032
• Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody.
  Miyanabe K, Yamashita T, Abe Y, Akiba H, Takamatsu Y, Nakakido M, Hamakubo T, Ueda T, Caaveiro JMM, Tsumoto K
  Biochemistry 57, 4177-4185 (2018)
  https://doi.org/10.1021/acs.biochem.8b00592
• Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity.
  Kawade R, Akiba H, Entzminger K, Maruyama T, Okumura CJ, Tsumoto K
  Prot. Eng. Des. Selec. 31, 243-247 (2018)
  https://doi.org/10.1093/protein/gzy008
• Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH17.
  Kusano-Arai O, Iwanari H, Kudo S, Kikuchi C, Yui A, Akiba H, Matsusaka K, Kaneda A, Fukayama M, Tsumoto K, Hamakubo T
  Monoclon. Antib. Immunodiagn. Immunother. 37, 1-11 (2018)
  https://doi.org/10.1089/mab.2017.0043

Books and Reviews

• Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins
  Akiba H, Tsumoto K
  Translat. Regulat. Sci. 2, 1-6 (2020) (Review)
  https://doi.org/10.33611/trs.2_1

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