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論文、著書

2018201620152014201320122011201020092008

 2018

  1. Takei Y.,Matsumura T.,Watanabe K.,Nakamine H.,Sudo T., Shimizu K.and Shimada Y.
    FGFRL1 deficiency reduces motility and tumorigenic potential of cells derived from oesophageal squamous cell carcinomas.
    Oncology letters 16 (1) : 809-814, 2018

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 2016

  1. Shimada Y., Okumura T.,Takei Y., Watanabe K., Nagata T., Nagata T., Hori T., Tsuchiya S., Tsukada K., and Shimizu K.
    Role of fibroblast growth factor receptors in esophageal squamous cell carcinoma.
    Esophagus 13(1) :30-41, 2016

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 2015

  1. Ueno T., Utsumi J., Toi M., Shimizu K.
    Characteristic Gene Expression Profiles of Human Fibroblasts and Breast Cancer Cell in a Newly Developed Bilateral Coculture System.
    Bio Med Research International Vol 2015 2015

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 2014

  1. Shimada Y., Okumura T., Nagata T., Hashimoto I., Sawada S., Yoshida T., Fukuoka J.,Shimizu K. and Tsukada K.
    Expression analysis of fibroblast growth factor receptor-like 1 (FGFRL1) in esophageal squamous cell carcinoma.
    Esophagus 11(1) : 48-53, 2014

  2. Suehiro K., Nakamura Y., Xu S., Uda Y., Matsumura T., Yamaguchi Y., Okamura H., Yamashita T. and Takei Y.
    Ecto-domain phosphorylation promotes functional recovery from spinal cord injury.
    Scientific Reports 4 : 4972, 2014

  3. Okumura T., Shimada Y., Moriyama M., Takei Y., Omura T., Sekine S., Nagata T., Shimizu K. and Tsukada K.
    MicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architecture in vivo.
    Int J Oncol. 44(6) : 1923-32, 2014

  4. Ikeda A., Shimizu T., Matsumoto Y., Fujii Y., Eso Y., Inuzuka T., Mizuguchi A., Shimizu K., Hatano E., Uemoto S., Chiba T. and Marusawa H.
    Leptin Receptor Somatic Mutations are Frequent in HCV-Infected Cirrhotic Liver and Associate with Hepatocellular Carcinoma
    Gastroenterology 146(1):222-232, 2014

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 2013

  1. Kawashima M., Iwamoto N., Kawaguchi-Sakita N., Sugimoto M., Ueno T., Mikami Y., Terasawa K., Sato T., Tanaka K.,Shimizu K. and Toi M.
    High-sesolution imaging mass spectrometry reveals detailed spatial distribution of phosphatidylinositols in human breast cancer.
    Canser Science104(10) 1372-1379, 2013


  2. Watanabe M, Terasawa K, Kaneshiro K., Uchimura U., Yamamoto R., Fukuyama Y.,Shimizu K, Sato T. and Tanaka K.
    Improvement of mass spectrometry analysis of glycoproteins by MALDI-MS using 3-aminoquinoline/alpha-cyano-4-hydroxycinnamic acid.
    Analytical and Bioanalytical Chemistry. 2013; 405: 4289-93.


  3. Ohtsuru S. , Ueda Y., Marusawa H., Inuzuka T., Nishijima N., Nasu A., Shimizu K, Koike K., Uemoto S. and Chiba T.
    Dynamics of defective hepatitis C virus clones in reinfected liver grafts in liver transplant recipients; ultra-deep sequencing analysis.
    J Clin Microbiol. 51(11) : 3645-3652, 2013


  4. Kim S. K., Komori J., Shimizu T., Matsumoto Y., Minaki Y., Kohno K., Shimizu K, Uemoto S., Chiba T. and Marusawa H.
    A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations.
    Int.J.Cancer 134(5)1067-1076, 2013


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 2012

  1. Ichikawa T, Sato F, Terasawa K, Tsuchiya S., Toi M., Tsujimoto G. and Shimizu K.
    Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells.
    Plos One.7(2) 1-11,2012


  2. Ozawa K, Tsumoto H, Wei W, Tang C., Komatsubara AT., Kawafune H., Shimizu K., Liu L. and Tsujimoto G.
    Proteomic analysis of the role of S-nitrosoglutathione reductase in lipopolysaccharide-challenged mice.
    Proteomics. 2012; 12: 2024-35.


  3. Komatsubara AT, Asano T, Tsumoto H, Shimizu K., Nishiuchi T., Yoshizumi M. and Ozawa K.
    Proteomic analysis of S-nitrosylation induced by 1-methyl-4-phenylpyridinium (MPP+).
    Proteome Science. 2012; 10(1);74


  4. Kaneshiro K, Watanabe M, Terasawa K, Uchiyama H., Fukuyama Y., Iwamoto S., Sato T., Shimizu K., Tsujimoto G. and Tanaka K.
    Rapid Quantitative Profiling of N-Glycan by the Glycan-Labeling Method Using 3-Aminoquinoline/alpha-Cyano-4-hydroxycinnamic Acid.
    Analytical Chemistry. 2012; 84: 7146-51.


  5. Nishijima, Norihiro; Marusawa, Hiroyuki; Ueda, Yoshihide;Takahashi, Ken; Nasu, Akihiro; Osaki, Yukio; Kou, Tadayuki;Yazumi, Shujiro; Fujiwara, Takeshi; Tsuchiya, Soken;Shimizu, Kazuharu; Uemoto, Shinji; Chiba, Tsutomu.
    Dynamics of Hepatitis B Virus Quasispecies in Association with Nucleos(t)ide Analogue Treatment Determined by Ultra-Deep Sequencing.
    PloS One. 7(4) e35052, 2012


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 2011

  1. Tsuchiya S., Fujiwara T., Sato F., Shimada Y., Tanaka E., Sakai Y., Shimizu K. and Tsujimoto G.
    MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-Like 1 (FGFRL1).
    J. Biol. Chem. 286(1) 420-428,2011.

  2. Sato F, Tsuchiya S., Meltzer S. and Shimizu K.
    MicroRNAs and Epigenetics.
    FEBS J. 278, 1598-1609, 2011.

  3. Sato F, Hatano E, Kitamura K, Myomoto A, Fujiwara T, Takizawa S, Tsuchiya S, Tsujimoto G, Uemoto S, Shimizu K.
    MicroRNA Profile Predicts Recurrence After Resection in Patients with Hepatocellular Carcinoma within the Milan Criteria.
    PLoS One 6(1)e16435. 2011.

  4. Terasawa K, Shimizu K, Tsujimoto G.
    Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers.
    J Nucleic Acids.8 2011:1-6

  5. Nasu A, Marusawa H, Ueda Y, Nishijima N, Takahashi K, Osaki Y, Yamashita Y, Inokuma T, Tamada T, Fujiwara T, Sato F, Shimizu K, Chiba T.
    Genetic heterogeneity of hepatitis C virus in association with antiviral therapy determined by ultra-deep sequencing.
    PLoS One.6(9) e24907, 2011

  6. Doi M,, Ishida A., Miyake A., Sato M., Komatsu R., Yamazaki F., Kimura I., Tsuchiya S., Kori H., Seo K., Yamaguchi Y., Matsuo M., Fustin J- M., Tanaka R., Santo Y., Yamada H., Takahashi Y., Araki M., Nakao K., Aizawa S., Kobayashi M., Obrietan K., Tsujimoto G. and Okamura H.
    Temporal Regulation of Intracellular G protein Signaling Mediates Intercellular Synchrony and Circadian Rhythmicity in Mammalian Pacemaker Neurons.
    Nat. Commun. 2, 327, 2011.

  7. Imanaka Y, Tsuchiya S, Sato F, Shimada Y, Shimizu K, Tsujimoto G.
    MicroRNA-141 Confers Resistance to Cisplatin-induced Apoptosis by Targeting YAP1 in Human Esophageal Squamous Cell Carcinoma.
    J. Human Genetics, 56, 270-276, 2011.

  8. Tetsuo Ito*, Fumiaki Sato*, Takatsugu Kan, Yulan Cheng, Stefan David, Rachana Agarwal, Bogdan C. Paun, Zhe Jin, Alexandru V. Olaru, James P. Hamilton, Florin M. Selaru, Jian Yang, Nobutoshi Matsumura, Kazuharu Shimizu, John M. Abraham, Yutaka Shimada, Yuriko Mori, and Stephen J. Meltzer. *: these authors contributed equally to this work.
    Polo-like Kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer
    International Journal of Cancer 129(9)2134-2146,2011

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 2010

  1. Ortiz CM, Ito T, Hashimoto Y, Nagayama S, Iwai A, Tsunoda S, Sato F, Martorell M, Garcia JA, Perez A, Shimada Y.
    Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines.
    Diagn Pathol. 2010 Jun 21;5:41.

  2. Atsuhiko Ichimura, Yoshinao Ruike, Kazuya Terasawa,Kazuharu Shimizu, and Gozoh Tsujimoto.
    MicroRNA-34a Inhibits Cell Proliferation by Repressing Mitogen-Activated Protein Kinase Kinase 1 during Megakaryocytic Differentiation of K562 Cells.
    Mol Pharmacol 77:1016-1024, 2010.

  3. Ruike Y, Imanaka Y, Sato F, Shimizu K, Tsujimoto G.
    Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing.
    BMC Cancer, 2010, 11:137.

  4. Nomura H. and Shimizu K.
    Stress in Tin-Doped Indium Oxide Thin Films Formed on Substrates by Sputtering.
    Japanese Journal of Applied Physics 49(2), 25501-25508, 2010,.

    5.

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 2009

  1. Tsuchiya S; Oku M; Imanaka Y; Kunimoto R; Okuno Y; Terasawa K; Sato F; Tsujimoto G; Shimizu K.
    MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells.
    Nucleic Acids Res.37(11)3821-3827, 2009 .

  2. Shimada Y, Sato F, Shimizu K, Tsujimoto G, Tsukada K.
    cDNA microarray analysis of esophageal cancer: discoveries and prospects.
    Gen Thorac Cardiovasc Surg. 2009 Jul;57(7):347-56.

  3. Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Mori Y, Agarwal R, Paun BC, Jin Z, Olaru AV, Seralu FM, Hamilton JP, Yang J, Abraham JM, Meltzer SJ.
    The miR-25-93-106b cluster members function as oncomiRs regulating p21 and Bim in Barrett’s neoplasia.
    Gastroenterology, 136(5),1689-1700, 2009.

  4. Tsuchiya S., Terasawa K., Kunimoto R., Okuno Y., Sato F., Shimizu K. and Tsujimoto G.
    Biogenesis and Function Mechanisms of Micro- RNAs and Their Role as Oncogenes and Tumor Suppressors. In Nakanishi S., Kageyama R. and Watanabe D. (eds.),
    Systems Biology - The Challenge of Complexity.     Springer Press, Tokyo, pp.183-189. 2009

  5. Terasawa K; Ichimura A; Sato F; Shimizu K; Tsujimoto G.
    Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells.
    FEBS Journal, 276(12): 3269-76, 2009.

  6. Sato F, Tsuchiya S, Terasawa K, Tsujimoto G.
    Intra-platform Repeatability and Inter-platform Comparability of MicroRNA Microarray Technology.
    PLoS ONE.4(5) e5540, 2009.

  7. Jin Z, Cheng Y, Gu W, Zheng Y, Sato F, Mori Y, Olaru AV, Paun BC, Yang J, Kan T, Ito T, Hamilton JP, Selaru FM, Agarwal R, David S, Abraham JM, Wolfsen HC, Wallace MB, Shaheen NJ, Washington K, Wang J, Canto MI, Bhattacharyya A, Nelson MA, Wagner PD, Romero Y, Wang KK, Feng Z, Sampliner RE, Meltzer SJ.
    A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett’s Esophagus.
    Cancer Res, 69(10), 4112-15, 2009.

  8. Tsuchiya S., Tachida Y., Segi-Nishida E., Okuno Y., Tamba S., Tsujimoto G., Tanaka S. and Sugimoto Y.
    Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method.
    BMC Genomics 10, 35, 2009.

  9. Takano H., Nakazawa S., Shirata N., Tamba S., Furuta K., Tsuchiya S., Morimoto K., Itano N., Irie A., Ichikawa A., Kimata K., Nakayama K., Sugimoto Y. and Tanaka S.
    Involvement of CD44 in mast cell proliferation during terminal differentiation.
    Lab. Invest. 89, 446-455, 2009.

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 2008

  1. Ruike Y., Ichimura A., Tsuchiya S., Shimizu K., Kunimoto R., Okuno Y. and Tsujimoto G.
    Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines.
    J. Hum. Genet. 53, 515-523, 2008.

  2. Tsuchiya S., Okuno Y. and Tsujimoto G.
    MicroRNAs and discovery of new targets. In Innocenti F. (ed.),
    Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response. Humana Press, Totowa, NJ, pp.47-56. 2008

  3. Iwaisako K, Hatano E, Taura K, Nakajima A, Tada M, Seo S, Tamaki N, Sato F, Ikai I, Uemoto S, Kinoshita M.
    Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells.
    Journal of Hepatology, 2008;49(5):768-78. Epub: 2008 Jul 15.

  4. Jin Z, Cheng Y, Olaru A, Kan T, Yang J, Paun B, Ito T, Hamilton JP, David S, Agarwal R, Selaru FM, Sato F, Abraham JM, Beer DG, Mori Y, Shimada Y, Meltzer SJ.
    Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors.
    Int J Cancer. 2008 Nov 15;123(10):2331-6.

  5. Jin Z, Mori Y, Hamilton JP, Olaru A, Sato F, Yang J, Ito T, Kan T, Agarwal R, Meltzer SJ.
    Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis.
    Cancer. 112(1):43-9, 2008.

  6. Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan T, Cheng Y, Paun B, David S, Beer DG, Agarwal R, Abraham JM, Meltzer SJ.
    Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression.
    Cancer Epidemiol Biomarkers Prev. 17(1):111-7, 2008.

  7. Ito T, Tanaka E, Kadowaki T, Kan T, Higashiyama M, Shiojima S, Tomoda S, Myoumoto A, Akiyama H, Nobumasa H, Matsumoto S, Miyamoto S, Mitsumori M, Sato F, Watanabe G, Itami A, Meltzer SJ, Tsujimoto G, Shimada Y.
    An ultrasensitive new DNA microarray chip provides gene expression profiles for preoperative esophageal cancer biopsies without RNA amplification.
    Oncology,30;73(5-6):366-375.

  8. Ito T, Shimada Y, Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru A, Hamilton JP, Yang J, Abraham JM, Meltzer SJ, Sato F.
    Pituitary Tumor-transforming gene 1 (PTTG1) increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma.
    Cancer Res, 2008, 68(9):3214-24.

  9. Sato F, Jin Z, Schulmann K, Wang J, Greenwald BD, Ito T, Kan T, Hamilton JP, Yang J, Paun B, David S, Olaru A, Cheng Y, Mori Y, Abraham JM, Yfantis HG, Wu TT, Fredericksen MB, Wang KK, Canto M, Romero Y, Feng Z, Meltzer SJ.
    Three-tiered Risk Stratification Model to Predict Progression in Barrett's Esophagus Using Epigenetic and Clinical Features.
    PLoS ONE.3(4)e1890, 2008.

  10. Takano H., Nakazawa S., Okuno Y., Shirata N., Tsuchiya S., Kainoh T., Takamatsu S., Furuta K., Taketomi Y., Naito Y., Takematsu H., Kozutsumi Y., Tsujimoto G., Murakami M., Kudo I., Ichikawa A., Nakayama K., Sugimoto Y. and Tanaka S.
    Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells.
    FEBS Lett. 582, 1444-1450, 2008.

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