What's new?

  May 6, 2021 The information on "Publications" has been updated..
  Apr. 14, 2021 The paper on "Amphiol, an antifungal pigment from Pseudogymnoascus sp. PF1464" has been published. [Fujita, K. et al. J. Nat. Prod. in press]
  Apr. 12, 2021 Our proposal symposium in PACIFICHEM2021 (Hawaii, Dec.16-21, 2021) was approved. [Chemical Communications through Natural and Synthetic Bioactive Compounds: Organizers, Liu, J.O., Kwon, H.J., Kikuchi, K., Irie, K., Kakeya, H.] . Call for additional abstarcts was closed on Apr. 12 in 2021.
  Feb. 16, 2021 The paper on "Heterogenous chemosensitivity of a panel of organoid cell lines derived from small cell neuroendocrine carcinoma of the uterine cervix"has been published. [Tanaka, M. et al., Human Cell. in press]
  Jan. 8, 2021 The paper on "Amycolapeptins A and B, cyclic nonadepsipetides produced by combined-culture of Amycolatopsis and Tsukamurella pulmonis" has been published. [Pan, C. et al. J. Org. Chem. 86, 1843, 2021]
  Nov. 1, 2020 The D/L-amino acids labeling kit based on our scientific results has been commercialy availabled (Catalog no. 19942, Nacalai Tesque, Japan).
  Aug. 31, 2020 The paper on "Highly sensitive labeling reagents for scarce natural products" has been published. [Kuranaga, T. et al. ACS Chem. Biol. 15, 2499, 2020] [Press release]
  May 27, 2020 The paper on "Methylation deficiency disrupts biological rhythms from bacteria to humans." has been published. [Fustin, J. et al. Commun. Biol. 3, 211, 2020] [Press release]
  Apr. 8, 2020 The paper on "Thioamycolamides A-E, sulfer-containing cycliclipopeptides produced by the rare actinomycete Amycolatopsis sp." has been published. [Pan, C. et al. Org. Lett. 22, 3014, 2020]
  Apr. 6, 2020 The paper on "Curcumin beta-D-glucuronide (CMG) exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity" has been published. [Ozawa-Umeta, H. et al. Cancer Sci. 111, 1785, 2020] [Press release]
  Jan. 15, 2020 The paper on "Cryptic chemical communication: Secondary metabolic responses revealed by microbial co-culture" has been published. [Liu, C. & Kakeya, H. Chem. Asian J. 15, 327, 2020] [Selected as a cover feature.]
  Nov. 2, 2019 The paper on "UCHL1 promotes HIF-1-dependent tumor cell malignancy in spheroid models" has been published. [Li, X. et al. Cancer Sci. 111, 239 2020]
  Oct. 10, 2019 The invited review entitled with "Precious Microorganisms as Productive Resources: Marine-derived Microorganisms and Combined-Culture" in Comprehensive Natural Products III: Chemistry and Biology has been published.
  Sep. 7, 2019 The paper on "Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)" has been published. [Takahashi, N. et al. Chem. Commun. 58, 13486, 2019]
  Aug. 16, 2019 Prof. Kakeya will give a plenary lecture entitled with "Continuing Fascination with Discovery Science: From Phenotypic Screening to Chemical Biology" at the Mona Sympoisum 2020 (Kingston, Jamaica, Jan. 2020)
  Aug. 7, 2019 The paper on "Chemical interaction of cryptic actinomycete metabolite 5-alkyl-1,2,3,4-tetrahydroquinolines through aggregate formation" has been published. [Sugiyama, R. et al. Angew. Chem. Int. Ed. 55, 11956, 2019] [Press release]
  Aug. 1, 2019 Recent progress on an innovative anticancer drug curcumin monoglucronide (CMG) will be presented at the 31th EORTC-NCI-AACR Symposium, Boston, MA, USA, Oct. 2019: Kakeya, H., Kishimoto, A., Umeta, H., Imaizumi, A., Kanai, M. "Development of an injectable water-soluble anticancer drug CMG for oxaliplatin-resistant colorectal cancer with KRAS mutation".
  Jul. 20, 2019 Prof. Kakeya will give a plenary lecture entitled with "Natural Products-Prompted Chemical Biology: Phenotypic Screening and a New Platform for Target Identification" at the 6th Tishler-Omura Symposium (Tokyo, Oct. 2019) [postponed due to the Tyhoon no.19]
  Jun. 13, 2019 The paper on "An nterferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through inhibition of interferon-stimulated genes" has been published. [Furutani, Y. et al. PLOS ONE. 14, e0216139] [Press release]
  Mar. 13, 2019 The paper on "Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis" has been published. [Jiang, Y. et al. Tetrahedron Lett. 60, 1072, 2019]
  Feb. 1, 2019 The paper on "Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines" has been published. [Ozaki, T. et al. Org. Biomol. Chem. 17, 2370, 2019] [Selcted as a HOT article collection.]
  Jan. 11, 2019 The 1st International Symposium on Chemical Communication (The 1st ISCC & The 4th Symposium) was held (2019-01-09`10, Tokyo).
  Nov. 17, 2018 Discovery and recent progress on a water-soluble curcumin monoglucronide (CMG) was presented at the 30th EORTC-NCI-AACR Symposium, Dublin, Ireland, Nov. 2018: Kakeya, H., Kishimoto, A., Imaizumi, A., Kanai, M. "Development of a synthetic water-soluble curcumin mono-beta-D-glucronide (CMG) as an innovative anticancer prodrug targeting KRAS-NF-kappa B signaling pathway".
  Jul. 25, 2018 The paper on "Discovery of presaccharothriolide X, a retro-Michael product of saccharothliolide B, from the rare actinomycets Saccharothrix sp. A1506" has been published. [Lu, S. et al. Org. Lett. 20, 4406, 2018] (Press release)
  Apr. 2, 2018 Our recent progress on a water-soluble curcumin monoglucronide (CMG) was presented at the GAP (Global Academic Programs) conference of Karolinska Institute in Sweden: Kanai, M., Imaizumi, A., Kakeya, H. "Development of a water-soluble curcumin monoglucronide (CMG) as a novel anticancer prodrug targeting KRAS-NF-kappa B signaling pathway", GAP (Global Academic Programs) conference, Stockholm, Sweden, May, 2018.
  Sep. 1, 2017 The paper on "Curcumin beta-D-glucuronide plays an important role to keep high levels of free-form curcumin in the blood." has been published. [Ozawa, H. et al. Biol. Pharm. Bull. 40, 1515, 2017] (Press release)
  Jul. 12, 2017 The project of a Grant-in-Aid for Scientific Research on Innovative Areas "Frontier Research on Chemical Communications" supported by The Ministry of Education, Cultures, Sports, Science and Techology, Japan (MEXT) has been launched. [Project Leader: Professor Hideaki Kakeya (Kyoto Univ.)]
  Apr. 3, 2017 Prof. Kakeya has been appointed as a section editor of natural products and chemical biology for the Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (CMSCE), ELSEVIER.
  Apr. 2, 2017 The paper on "Precursor-directed in situ synthesis of saccharothriolides G and H by the actinomycete Saccharothrix sp. A1506" has been published. [Lu, S. et al. J. Antibiot. 70 (1), in press, 2017] (The special issue in 2017 featuring Prof. Omura, S., a distinguished Novel Prize awardee in Physiology or Medicine 2015)
  Oct. 1, 2016 The research on "Screening of novel cccDNA modulator compounds, iCDMs" has been presented at The 2016 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses (Korea, Sep. 21-24, 2016)"
  Jul. 27, 2016 The paper on "Discovery and total synthesis of streptoaminals: Antimicrobial [5,5]-spirohemiaminals from the combined-culture of Streptomyces nigrescens and Tsukamurella pulmonis" has been published. [Sugiyama, R. et al. Angew. Chem. Int. Ed. 55, 10278, 2016] (Press release)
  Jun. 18, 2016 Professor Kakeya received the 1st Kobayashi Foundation Award for Cancer Research (Kobayashi Foundation for Cancer Research, Japan).
  Apr. 5, 2016 The paper on gNatural products-prompted chemical biology: Phenotypic screening and a new platform for target identificationh has been published. [Kakeya, H. Nat. Prod. Rep. 33, 648, 2016.]
  Oct. 30, 2015 The paper on gIn vivo linking of membrane lipids and the anion transporter band 3 with thiourea-modified amphiphilic lipid probeh has been published. [Moriyama, A. et al. Sci. Rep 5, 17427, 2015]
  Oct. 21, 2015 The paper on gStructure elucidation of verucopeptin, a HIF-1 inhibitory polyketide-hexapeptide hybrid metabolite from an actinomyceteh has been published. [Yoshimura, A. et al. Org. Lett. 17, 5364-5367, 2015] (Press release)
  Oct. 19, 2015 The paper on gAccurate detection of adenylation domains in nonribosormal peptide synthetases by an enzyme-linked immunosorbent assay system using active site-directed probes for adenylation domainsh has been published. [Ishikawa, F. et al. ACS Chem. Biol. 10, 2816, 2015] (Press release)
  Sep. 4, 2015 The paper on gFunctional profiling of adenylation domains in nonribosormal peptide synthetases by competitive activity-based protein profilingh has been published. [Kasai, S. et al. Chem. Commun. 51, 15764-15767, 2015] (Selected as a "Back Cover Highlight")
  Jun. 15, 2015 The paper on gTotal synthesis and antimicrobial activity of chlorocatechelin Ah has been published. [Kishimoto, S. et al. J. Org. Chem. 80, 6076, 2015]
  Jun. 1, 2015 The paper on gExpression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.h has been published. [Pia, J.H. et al. J. Biochem. 158, 477-484, 2015]
  May 29, 2015 The paper on gProfiling of nonribosomal peptide synthetase activities using chemical proteomic probes for adenylation domains.h has been published. [Ishikawa, F. et al. ACS Chem. Biol. 10, 1989-1997, 2015]
  Apr. 2, 2015 The paper on gSaccharothriolides A-C, novel phenyl-substituted 10-membered macrolides from a rare actinomycete Saccharothrix sp.h has been published. [Lu, S. et al. Chem. Commun. 51, 8074-8077, 2015]
  Apr. 1, 2015 The paper on g5-Alkyl-1,2,3,4-tetrahydroquinolines, new membrane-interacting lipophilic metabolites, produced by combined culture of Streptomyces nigrescens and Tsukamurella pulmonsish has been published. [Sugiyama, R. et al. Org. Lett. 17, 1918-1921, 2015]
  Feb. 17, 2015 The paper on "Development of novel HIF-1 inhibitors towards promising cancer chemotherapy" has been published. [Yasuda, Y. et al. Bioorg. Med. Chem. 23, 1776-1787, 2015]
  Jan. 24, 2015 The paper on " UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1ƒ¿" has been published. [Goto, Y. et al. Nat. Commun. 6:6153, 2015] (Press release)
  Dec. 12, 2014 The paper on " Balance between exocytosis and endocytosis determines the efficacy of sterol-targeting antibiotics" has been published. [Nishimura, S. et al. Chem. Biol. 21, 1690-1699, 2014] (Press release)
  June 13, 2014 Moriyama, A. (M2) received the Best Poster Presentation Award at 9th Annual Meeting of Japanese Society for Chemical Biology.
- Moriyama, A., Nishimura, S., Kakeya, H. Development of LiDEL method for understanding modes of action of membrane-targeting natural products-
  Apr. 2, 2014 The paper on "Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: Heronamides target saturated hydrocarbon chains in lipid membranes" has been published. [Sugiyama, R. et al. J. Am. Chem. Soc. 136, 5209-5212, 2014] (Press release)
  Nov. 12, 2013 The paper on "RNA-methylation-dependent RNA processing controls the speed of the circadian clock" has been published. [Fustin, JM. et al. Cell, 155, 793-806, 2014] (Press release)
  Apr. 1, 2013 The paper on 5-SOxT probe for chemical tagging of a drug target using 5-sulfonyl tetrazole has been published. [Otsuki, S. et al. Bioorg. Med. Chem. Lett. 23, 1608-1611, 2013]
  Apr. 20, 2012 Miss Hu, X.T.(M2) received the Best Poster Presentation Award at 8th Annual Conference of OOTR (Organization for Oncology and Translational Research). [http://www.ootr-institute.org/index.php ]
- Hu, X.T., Hattori, A., Tokiwa, R., Kakeya, H. A high content screening system to develop novel HIF-1 inhibitors disrupting its heterodimeric formation-
  Apr. 1, 2012 Member's Photo
  Mar. 26&27, 2011 Congratulation on Graduation!
  Apr. 1, 2011 Member's Photo
  Mar. 23&24, 2011 Congratulation on Graduation!
  Jan. 5, 2011 Mr. Tsunematsu (D3) received the Young Investigater Award at 52nd Sympoisum on The Chemistry of Natural Products.
-Tsunematsu, Y., Oishi, S., Fujii, N., Nishimura, S., Hattori, A., Kakeya, H. Isolation, Structure Elucidation, and Synthesis of Tryptopeptin A, a Novel TGF-ƒÀ signaling Pathway Inhibitor Produced by Streptomyces sp.-
  June 14, 2010 Press release. [Nishimura, S. et al. Nat. Chem. Biol., 6, 519-526 (2010).] . 
  Apr. 5, 2010 Member's photo.
  Mar. 23&24, 2010 Congratulation on Graduation!
  Mar. 1, 2010 Mr. Ohno (D1) received the Best Poster Presentation Award at 6th Annual Coference of OOTR (Organization for Oncology and Translational Research).
- Ohno, M., Hattori, A., Ueda, M., Kageyama, S., Yoshiki, T., Kakeya, H. Involvment of NF-Y in transcriptional regulation of the human C7orf24/GGCT gene.-
  Jul. 24, 2009 Baseball game.
  Apr. 1, 2009 Member's Photo.
  Mar. 31, 2009 Congratulation on Graduation!.
  Dec. 7, 2008 Hiking on Mt. Daimonji.
  Nov. 30, 2008. Baseball game.
  Sep. 1, 2008 Selected as an issue highlight and a cover page. [Cancer Sci. 99, 1853-1858, 2008.] . 
  Apr. 7, 2008 Memberfs Photo
  Apr. 4, 2008 Welcome Party (part 2)
  Mar. 18, 2008 Farewell&Welcome Party
  Apr. 1, 2007 Our laboratory starts.