Apr. 22, 2024 | The information on "Publications" has been updated. |
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Mar. 25, 2024 | The paper on "Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei.. [Kaneko, K. et al. J. Antibiot. in press]. [selected as a highlight article] [press release] | |
Jan. 10, 2024 | The paper on "A small colecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor"has been published. [Furutani, Y. et al. Cell Death Discov. 9, 216, 2023]. [press release] | |
Nov. 13, 2023 | The paper on "Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells"has been published. [Pan, Y. et al. Eur. J. Pharmacol. 960, 176156, 2023]. [press release] | |
Nov. 8, 2023 | The paper on "Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity." has been published. [Ochiai, T. et al. Commun. Chem. 6, 249, 2023]. | |
Jun. 17, 2023 | Prof. Kakeya gave a keynote lecture entitled "Development of an innovative
anticancer drug TBP1901, an injectable prodrug of curcumin" in the
2023 NSFC*1-JSPS-CAS*2 Forum: Translational Medicine and Innovative Drug Research at Tianjin,
China & on-line, Jun. 2023. (*1 Natural Science Foundation of China, *2 Chinese Academy of Science) |
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Feb. 6, 2023 | The paper on "Separation of amyloid ƒÀ fragment peptides with racemised
and isomerised aspartic acid residues using an original chiral resolution
labeling reagentt"has been published. [Ozaki, M. et al., Analyst 148, 1209, 2023]. [selected as Hot Articles & Cover Art] |
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Dec. 16, 2022 | Evaluation after completing our project "Frontier Research on Chemical Communications" (so called "ex-post evaluation") was "A+: Excellent". |
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Dec. 13, 2022 | The paper on "FK506 binding protein, FKBP12, promotes serine utilization
and negatively regulates threonine deaminase in fission yeast"has
been published. [Sasaki, M. et al., iScience, 25, 105659, 2022]. [press release] |
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Oct. 21, 2022 | The paper on "Pharmacologic characterization of TBP1901, a prodrug
form of curcumin, and CRISPR-Cas9 screen for therapeutic targets of curcuminl"has
been published. [Abe, T. et al., Eur. J. Pharmacol. 935, 175321, 2022]. [press release] |
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Oct. 3, 2022 | The paper on "Identification of the polyether ionophore lenoremycin
through a new screening strategy targeting cancer stem cell"has been
published. [Ikeda, H. et al., J. Antibiot. 75, 671, 2022]. [selected as a highlight article] [press release] |
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Sep. 5, 2022 | Our presentation on "Identification of the polyether ionophore lenoremycin
through a new screening strategy targeting cancer stem cell" was selected
as a late-breaking poster at the 81st Annual Meeting of the Japanese Cancer
Association (Yokohama, Japan, Sep. 2022). |
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Jul. 11, 2022 | The symposium on achievements of the project of a Grant-in-Aid for Scientific
Research on Innovative Areas "Frontier Research on Chemical Communications"was held on Jul. 9th (Sat.), 2022 at Kyoto, Japan. |
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Jun. 30, 2022 | The International Symposium "Future Drug Discovery Empowered by Chemical
Biology" will be held on Feb. 20-22, 2023 at Nara, Japan. |
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Feb. 1, 2022 | Our paper on "Identification and total synthesis of an unstable anticancer
macrolide presaccharothriolide Z produced by Saccharothrix sp. A1506" [Org. Lett. 23, 7106, 2021] has been highlited in the cetegory of "Chemistry
in Medicine and Biology" in the review article of Synfacts [Synfacts, 18, 0095, 2022]. |
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Jan. 14, 2022 | The paper on "Curcumin beta-D-glucuronide modulates an autoimmune
model of multiple sclerosis with altered gut microbiota in the ileum and
feces"has been published. [Khadka, S. et al., Front. Cell. Infect. Microbiol. 11, Article 772962]. [press release] |
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Jan. 7, 2022 | The paper on "Development and application of highly sensitive labeling
reagents for amino acids"has been published. [Kuranaga, T. & Kakeya,
H., Methods in Enzymol. in press, 2022]. iFree access & download site before Feb. 16, 2022j. [press release] |
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Nov. 5, 2021 | The paper on "Design, synthesis and biological activity of 16,17-dihydroheronamide C and ent-heronamide C"has been published. [Kanoh, N. et al., J. Org. Chem. 86, 16249, 2021. |
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Oct. 8, 2021 | The paper on "Identification and total synthesis of an unstable anticancer
macrolide presaccharothriolide Z produced by Saccharothrix sp. A1506"has been published. [Kuranaga, T. et al., Org. Lett. 23, 7106, 2021. |
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Sep. 1, 2021 | The paper on "Design, synthesis, and target identification of new
hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety"has been published. [Sakai, M. et al., Bioorg. Med. Chem. 46, 116375, 2021. |
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Aug. 1, 2021 | The paper on "Targeting hypoxia-inducible factor 1 (HIF-1) signaling
with natural products towards cancer chemotherapy"has been published.
[Ikeda, H. & Kakeya, H., J. Antibiot. 74, 74, 687-695, 2021. [The special issue in "Approach toward cancer-targeting therapy by microbial origin"] |
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Aug. 1, 2021 | Our proposal symposium (#79) in PACIFICHEM2021 (Hawaii, Dec.16-21, 2021) was approved. [Chemical Communications through Natural and Synthetic Bioactive Compounds: Organizers; Liu, J.O., Kwon, H.J., Kikuchi, K., Irie, K., Kakeya, H.].
The schedule for oral and poster presentations was fixed. |
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Apr. 14, 2021 | The paper on "Amphiol, an antifungal pigment from Pseudogymnoascus sp. PF1464" has been published. [Fujita, K. et al. J. Nat. Prod. 84, 986, 2021]. |
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Feb. 16, 2021 | The paper on "Heterogenous chemosensitivity of a panel of organoid
cell lines derived from small cell neuroendocrine carcinoma of the uterine
cervix"has been published. [Tanaka, M. et al., Human Cell. 34, 889, 2021.] |
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Jan. 8, 2021 | The paper on "Amycolapeptins A and B, cyclic nonadepsipetides produced by combined-culture of Amycolatopsis and Tsukamurella pulmonis" has been published. [Pan, C. et al. J. Org. Chem. 86, 1843, 2021] |
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Nov. 1, 2020 | The D/L-amino acids labeling kit based on our scientific results has been
commercialy availabled (Catalog no. 19942, Nacalai Tesque, Japan). |
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Aug. 31, 2020 | The paper on "Highly sensitive labeling reagents for scarce natural
products" has been published. [Kuranaga, T. et al. ACS Chem. Biol. 15, 2499, 2020] [Press release] |
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May 27, 2020 | The paper on "Methylation deficiency disrupts biological rhythms from
bacteria to humans." has been published. [Fustin, J. et al. Commun. Biol. 3, 211, 2020] [Press release] |
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Apr. 8, 2020 | The paper on "Thioamycolamides A-E, sulfer-containing cycliclipopeptides
produced by the rare actinomycete Amycolatopsis sp." has been published.
[Pan, C. et al. Org. Lett. 22, 3014, 2020] |
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Apr. 6, 2020 | The paper on "Curcumin beta-D-glucuronide (CMG) exhibits anti-tumor
effects on oxaliplatin-resistant colon cancer with less toxicity"
has been published. [Ozawa-Umeta, H. et al. Cancer Sci. 111, 1785, 2020] [Press release] |
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Jan. 15, 2020 | The paper on "Cryptic chemical communication: Secondary metabolic
responses revealed by microbial co-culture" has been published. [Liu,
C. & Kakeya, H. Chem. Asian J. 15, 327, 2020] [Selected as a cover feature.] |
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Nov. 2, 2019 | The paper on "UCHL1 promotes HIF-1-dependent tumor cell malignancy
in spheroid models" has been published. [Li, X. et al. Cancer Sci. 111, 239 2020] |
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Oct. 10, 2019 | The invited review entitled with "Precious Microorganisms as Productive
Resources: Marine-derived Microorganisms and Combined-Culture" in
Comprehensive Natural Products III: Chemistry and Biology has been published. |
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Sep. 7, 2019 | The paper on "Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible
factor 1 (HIF-1)" has been published. [Takahashi, N. et al. Chem. Commun. 58, 13486, 2019] |
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Aug. 16, 2019 | Prof. Kakeya will give a plenary lecture entitled with "Continuing
Fascination with Discovery Science: From Phenotypic Screening to Chemical
Biology" at the Mona Sympoisum 2020 (Kingston, Jamaica, Jan. 2020) |
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Aug. 7, 2019 | The paper on "Chemical interaction of cryptic actinomycete metabolite
5-alkyl-1,2,3,4-tetrahydroquinolines through aggregate formation"
has been published. [Sugiyama, R. et al. Angew. Chem. Int. Ed. 55, 11956, 2019] [Press release] |
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Aug. 1, 2019 | Recent progress on an innovative anticancer drug curcumin monoglucronide (CMG) will be presented at the 31th EORTC-NCI-AACR Symposium, Boston, MA, USA, Oct. 2019: Kakeya, H., Kishimoto, A., Umeta, H., Imaizumi, A., Kanai, M. "Development of an injectable water-soluble anticancer drug CMG for oxaliplatin-resistant colorectal cancer with KRAS mutation". | |
Jul. 20, 2019 | Prof. Kakeya will give a plenary lecture entitled with "Natural Products-Prompted
Chemical Biology: Phenotypic Screening and a New Platform for Target Identification"
at the 6th Tishler-Omura Symposium (Tokyo, Oct. 2019) [postponed due to
the Tyhoon no.19] |
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Jun. 13, 2019 | The paper on "An nterferon-like small chemical compound CDM-3008 suppresses
hepatitis B virus through inhibition of interferon-stimulated genes"
has been published. [Furutani, Y. et al. PLOS ONE. 14, e0216139] [Press release] |
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Mar. 13, 2019 | The paper on "Enhancement of saccharothriolide production and discovery
of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis" has been published. [Jiang, Y. et al. Tetrahedron Lett. 60, 1072, 2019] |
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Feb. 1, 2019 | The paper on "Identification of the common biosynthetic gene cluster
for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines"
has been published. [Ozaki, T. et al. Org. Biomol. Chem. 17, 2370, 2019] [Selcted as a HOT article collection.] |
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Jan. 11, 2019 | The 1st International Symposium on Chemical Communication (The 1st ISCC & The 4th Symposium) was held (2019-01-09`10, Tokyo). |
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Nov. 17, 2018 | Discovery and recent progress on a water-soluble curcumin monoglucronide
(CMG) was presented at the 30th EORTC-NCI-AACR Symposium, Dublin, Ireland,
Nov. 2018: Kakeya, H., Kishimoto, A., Imaizumi, A., Kanai, M. "Development
of a synthetic water-soluble curcumin mono-beta-D-glucronide (CMG) as an
innovative anticancer prodrug targeting KRAS-NF-kappa B signaling pathway". |
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Jul. 25, 2018 | The paper on "Discovery of presaccharothriolide X, a retro-Michael
product of saccharothliolide B, from the rare actinomycets Saccharothrix sp. A1506" has been published. [Lu, S. et al. Org. Lett. 20, 4406, 2018] (Press release) |
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Apr. 2, 2018 | Our recent progress on a water-soluble curcumin monoglucronide (CMG) was
presented at the GAP (Global Academic Programs) conference of Karolinska
Institute in Sweden: Kanai, M., Imaizumi, A., Kakeya, H. "Development
of a water-soluble curcumin monoglucronide (CMG) as a novel anticancer
prodrug targeting KRAS-NF-kappa B signaling pathway", GAP (Global
Academic Programs) conference, Stockholm, Sweden, May, 2018. |
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Sep. 1, 2017 | The paper on "Curcumin beta-D-glucuronide plays an important role
to keep high levels of free-form curcumin in the blood." has been
published. [Ozawa, H. et al. Biol. Pharm. Bull. 40, 1515, 2017] (Press release) |
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Jul. 12, 2017 | The project of a Grant-in-Aid for Scientific Research on Innovative Areas "Frontier Research on Chemical Communications" supported by The Ministry of Education, Cultures, Sports, Science and Techology, Japan (MEXT) has been launched. [Project Leader: Professor Hideaki Kakeya (Kyoto Univ.)] |
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Apr. 3, 2017 | Prof. Kakeya has been appointed as a section editor of natural products
and chemical biology for the Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
(CMSCE), ELSEVIER. |
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Apr. 2, 2017 | The paper on "Precursor-directed in situ synthesis of saccharothriolides G and H by the actinomycete Saccharothrix sp. A1506" has been published. [Lu, S. et al. J. Antibiot. 70 (1), in press, 2017] (The special issue in 2017 featuring Prof. Omura, S., a distinguished Novel
Prize awardee in Physiology or Medicine 2015) |
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Oct. 1, 2016 | The research on "Screening of novel cccDNA modulator compounds, iCDMs"
has been presented at The 2016 International HBV Meeting: The Molecular
Biology of Hepatitis B Viruses (Korea, Sep. 21-24, 2016)" |
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Jul. 27, 2016 | The paper on "Discovery and total synthesis of streptoaminals: Antimicrobial
[5,5]-spirohemiaminals from the combined-culture of Streptomyces nigrescens and Tsukamurella pulmonis" has been published. [Sugiyama, R. et al. Angew. Chem. Int. Ed. 55, 10278, 2016] (Press release) |
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Jun. 18, 2016 | Professor Kakeya received the 1st Kobayashi Foundation Award for Cancer
Research (Kobayashi Foundation for Cancer Research, Japan). |
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Apr. 5, 2016 | The paper on gNatural products-prompted chemical biology: Phenotypic screening
and a new platform for target identificationh has been published. [Kakeya,
H. Nat. Prod. Rep. 33, 648, 2016.] |
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Oct. 30, 2015 | The paper on gIn vivo linking of membrane lipids and the anion transporter
band 3 with thiourea-modified amphiphilic lipid probeh has been published.
[Moriyama, A. et al. Sci. Rep 5, 17427, 2015] |
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Oct. 21, 2015 | The paper on gStructure elucidation of verucopeptin, a HIF-1 inhibitory
polyketide-hexapeptide hybrid metabolite from an actinomyceteh has been
published. [Yoshimura, A. et al. Org. Lett. 17, 5364-5367, 2015] (Press release) |
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Oct. 19, 2015 | The paper on gAccurate detection of adenylation domains in nonribosormal
peptide synthetases by an enzyme-linked immunosorbent assay system using
active site-directed probes for adenylation domainsh has been published.
[Ishikawa, F. et al. ACS Chem. Biol. 10, 2816, 2015] (Press release) |
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Sep. 4, 2015 | The paper on gFunctional profiling of adenylation domains in nonribosormal
peptide synthetases by competitive activity-based protein profilingh has
been published. [Kasai, S. et al. Chem. Commun. 51, 15764-15767, 2015] (Selected as a "Back Cover Highlight") |
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Jun. 15, 2015 | The paper on gTotal synthesis and antimicrobial activity of chlorocatechelin
Ah has been published. [Kishimoto, S. et al. J. Org. Chem. 80, 6076, 2015] |
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Jun. 1, 2015 | The paper on gExpression, purification and enzymatic characterization of
a recombinant human ubiquitin-specific protease 47.h has been published.
[Pia, J.H. et al. J. Biochem. 158, 477-484, 2015] |
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May 29, 2015 | The paper on gProfiling of nonribosomal peptide synthetase activities using
chemical proteomic probes for adenylation domains.h has been published.
[Ishikawa, F. et al. ACS Chem. Biol. 10, 1989-1997, 2015] |
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Apr. 2, 2015 | The paper on gSaccharothriolides A-C, novel phenyl-substituted 10-membered
macrolides from a rare actinomycete Saccharothrix sp.h has been published. [Lu, S. et al. Chem. Commun. 51, 8074-8077, 2015] |
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Apr. 1, 2015 | The paper on g5-Alkyl-1,2,3,4-tetrahydroquinolines, new membrane-interacting lipophilic metabolites, produced by combined culture of Streptomyces nigrescens and Tsukamurella pulmonsish has been published. [Sugiyama, R. et al. Org. Lett. 17, 1918-1921, 2015] |
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Feb. 17, 2015 | The paper on "Development of novel HIF-1 inhibitors towards promising
cancer chemotherapy" has been published. [Yasuda, Y. et al. Bioorg. Med. Chem. 23, 1776-1787, 2015] |
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Jan. 24, 2015 | The paper on " UCHL1 provides diagnostic and antimetastatic strategies
due to its deubiquitinating effect on HIF-1ƒ¿" has been published.
[Goto, Y. et al. Nat. Commun. 6:6153, 2015] (Press release) |
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Dec. 12, 2014 | The paper on " Balance between exocytosis and endocytosis determines
the efficacy of sterol-targeting antibiotics" has been published.
[Nishimura, S. et al. Chem. Biol. 21, 1690-1699, 2014] (Press release) |
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June 13, 2014 | Moriyama, A. (M2) received the Best Poster Presentation Award at 9th Annual
Meeting of Japanese Society for Chemical Biology. - Moriyama, A., Nishimura, S., Kakeya, H. Development of LiDEL method for understanding modes of action of membrane-targeting natural products- |
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Apr. 2, 2014 | The paper on "Structure and biological activity of 8-deoxyheronamide
C from a marine-derived Streptomyces sp.: Heronamides target saturated hydrocarbon chains in lipid membranes"
has been published. [Sugiyama, R. et al. J. Am. Chem. Soc. 136, 5209-5212, 2014] (Press release) |
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Nov. 12, 2013 | The paper on "RNA-methylation-dependent RNA processing controls the
speed of the circadian clock" has been published. [Fustin, JM. et
al. Cell, 155, 793-806, 2014] (Press release) |
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Apr. 1, 2013 | The paper on 5-SOxT probe for chemical tagging of a drug target using 5-sulfonyl
tetrazole has been published. [Otsuki, S. et al. Bioorg. Med. Chem. Lett. 23, 1608-1611, 2013] |
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Apr. 20, 2012 | Miss Hu, X.T.(M2) received the Best Poster Presentation Award at 8th Annual
Conference of OOTR (Organization for Oncology and Translational Research).
[http://www.ootr-institute.org/index.php ] - Hu, X.T., Hattori, A., Tokiwa, R., Kakeya, H. A high content screening system to develop novel HIF-1 inhibitors disrupting its heterodimeric formation- |
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Apr. 1, 2012 | Member's Photo |
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Mar. 26&27, 2011 | Congratulation on Graduation! |
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Apr. 1, 2011 | Member's Photo |
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Mar. 23&24, 2011 | Congratulation on Graduation! |
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Jan. 5, 2011 | Mr. Tsunematsu (D3) received the Young Investigater Award at 52nd Sympoisum
on The Chemistry of Natural Products. -Tsunematsu, Y., Oishi, S., Fujii, N., Nishimura, S., Hattori, A., Kakeya, H. Isolation, Structure Elucidation, and Synthesis of Tryptopeptin A, a Novel TGF-ƒÀ signaling Pathway Inhibitor Produced by Streptomyces sp.- |
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June 14, 2010 | Press release. [Nishimura, S. et al. Nat. Chem. Biol., 6, 519-526 (2010).] . |
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Apr. 5, 2010 | Member's photo. |
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Mar. 23&24, 2010 | Congratulation on Graduation! |
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Mar. 1, 2010 | Mr. Ohno (D1) received the Best Poster Presentation Award at 6th Annual
Coference of OOTR (Organization for Oncology and Translational Research). - Ohno, M., Hattori, A., Ueda, M., Kageyama, S., Yoshiki, T., Kakeya, H. Involvment of NF-Y in transcriptional regulation of the human C7orf24/GGCT gene.- |
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Jul. 24, 2009 | Baseball game. |
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Apr. 1, 2009 | Member's Photo. |
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Mar. 31, 2009 | Congratulation on Graduation!. |
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Dec. 7, 2008 | Hiking on Mt. Daimonji. |
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Nov. 30, 2008. | Baseball game. |
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Sep. 1, 2008 | Selected as an issue highlight and a cover page. [Cancer Sci. 99, 1853-1858,
2008.] . |
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Apr. 7, 2008 | Memberfs Photo . |
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Apr. 4, 2008 | Welcome Party (part 2). |
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Mar. 18, 2008 | Farewell&Welcome Party. |
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Apr. 1, 2007 | Our laboratory starts. |