Publications

2022

  1. Nakagawa K, Watanabe H, Kaide S, Ono M.
    Structure-Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes
    ACS Med. Chem. Lett. 13(10) 1598-1605 (2022)
  2. Kaide S, Watanabe H, Iikuni S, Hasegawa M, Ono M.
    Synthesis and Evaluation of 18F-Labeled Chalcone Analogue for Detection of α-Synuclein Aggregates in the Brain Using the Mouse Model
    ACS Chem. Neurosci. 13(20) 2982-2990 (2022)
  3. Nakashima K, Iikuni S, Watanabe H, Ono M.
    Application of the Chelator-based Clickable Radiotheranostic Platform to Moderate-molecular-weight Ligands
    ACS Med. Chem. Lett. 13(10) 1642-1647 (2022)
  4. Iikuni S, Ohara T, Watanabe H, Ono M.
    Structure-activity relationships and pharmacokinetics of 111In-labeled glucagon-like peptide-1 receptor-targeting exendin-4 derivatives conjugated with albumin binder moieties
    Mol. Pharm. 19(8) 2832-2839 (2022)
  5. Iikuni S, Tarumizu Y, Tsuchihashi S, Ohara T, Watanabe H, Ono M.
    Synthesis and evaluation of novel 111In-labeled picolinic acid-based radioligands containing an albumin binder for development of radiotheranostic platform
    Mol. Pharm. 19(8) 2725-2736 (2022)
  6. Akasaka T, Watanabe H, Kaide S, Iikuni S, Hasegawa M, Ono M.
    Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes
    Bioorg. Med. Chem. Lett. 64 128679 (2022)
  7. Iikuni S, Kamei I, Ohara T, Watanabe H, Ono M.
    Development of an 111In-Labeled Glucagon-Like Peptide-1 Receptor-Targeting Exendin-4 Derivative that Exhibits Reduced Renal Uptake
    Mol. Pharm. 19(3) 1019-1027 (2022)
  8. Saito K, Watanabe H, Iikuni S, Ono M.
    Development of novel 67/68Ga-labeled pyridyl benzofuran derivatives as islet amyloid imaging probes
    Nucl. Med. Biol. 106-107 72-79 (2022)
  9. Watanabe H, Maekawa R, Iikuni S, Kakae M, Matsuo N, Shirakawa H, Kaneko S, Ono M.
    Characterization of Radioiodinated Diaryl Oxadiazole Derivatives as SPECT Probes for Detection of Myelin in Multiple Sclerosis
    ACS Chem. Neurosci. 13(3) 363-369 (2022)
  10. Shimizu Y, Koyasu S, Suzukida M, Izumi K, Kidera E, Shindo T, Saga T, Ono M, Takaori-Kondo A, Nakamoto Y.
    Development of a novel Indium-111 radiolabeled mogamulizumab targeting CCR4 for imaging adult T-cell leukemia/lymphoma in vivo
    Ann. Nucl. Med. 36(3) 319-326 (2022)
  11. Kaide S, Watanabe H, Iikuni S, Hasegawa M, Itoh K, Ono M.
    Chalcone Analogue as New Candidate for Selective Detection of α-Synuclein Pathology
    ACS Chem. Neurosci. 13(1) 16-26 (2022)

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2021

  1. Ogawa Y, Kimura H, Fujimoto H, Kawashima H, Toyoda K, Mukai E, Yagi Y, Ono M, Inagaki N, Saji H.
    Development of Novel Radioiodinated Exendin-4 Derivatives Targeting GLP-1 Receptor for Detection of β-cell Mass
    Bioorg. Med. Chem. 52 116496 (2021)
  2. Iikuni S, Kitano A, Watanabe H, Ono M.
    Feasibility of 99mTc-hydroxamamide complex based on (iodophenyl)butyric acid as albumin-binding moiety for tumor imaging via in vivo labeling of albumin
    Bioorg. Med. Chem. Lett. 53 128417 (2021)
  3. Shimizu Y, Ando M, Iikuni S, Watanabe H, Ono M.
    Development of a hydroxamamide-based bifunctional chelating agent to prepare technetium-99m-labeled bivalent ligand probes
    Sci. Rep. 11 18714 (2021)
  4. Iikuni S, Tarumizu Y, Nakashima K, Higaki Y, Ichikawa H, Watanabe H, Ono M.
    Radiotheranostics using a novel 225Ac-labeled radioligand with improved pharmacokinetics targeting prostate-specific membrane antigen
    J. Med. Chem. 64(18) 13429-13438 (2021)
  5. Fujimoto H, Fujita N, Hamamatsu K, Murakami T, Nakamoto Y, Saga T, Ishimori T, Shimizu Y, Watanabe H, Sano K, Harada N, Nakamura H, Toyoda K, Kimura H, Nakagawa S, Hirai M, Murakami A, Ono M, Togashi K, Saji H, Inagaki N.
    First-In-Human Evaluation of Positron Emission Tomography/Computed Tomography with [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas
    Front. Endocrinol. 12, 717101 (2021)
  6. Nakashima K, Iikuni S, Watanabe H, Ono M.
    Development of a novel radiotheranostic platform with a DOTA-based trifunctional chelating agent
    Chem. Commun. 57 6432-6435 (2021)
  7. Watanabe H, Idoko Y, Iikuni S, Ide T, Shimizu Y, Nakamoto Y, Ono M.
    Synthesis and biological evaluation of novel 18F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain
    Bioorg. Med. Chem. Lett. 43 128098 (2021)
  8. Watanabe H, Kishimoto T, Kaide S, Tarumizu Y, Tatsumi H, Iikuni S, Ono M.
    Characterization and Optimization of Radioiodinated Benzimidazopyrimidine and Pyridoimidazopyridine Derivatives for Development of Tau Imaging Probes
    ACS Med. Chem. Lett. 12(5) 805-811 (2021)
  9. Iikuni S, Okada Y, Shimizu Y, Watanabe H, Ono M.
    Modulation of pharmacokinetics of radioligand targeting carbonic anhydrase-IX utilizing albumin-binding moiety
    Mol. Pharm. 18(3) 966-975 (2021)
  10. Shimizu Y, Nakai Y, Watanabe H, Iikuni S, Ono M, Saji H, Kuge Y, Saga T, Nakamoto Y.
    Increased [18F]FMISO accumulation under hypoxia by multi-drug resistant protein 1 inhibitors
    EJNMMI res. 11 9 (2021)
  11. Watanabe H, Tarumizu Y, Kaide S, Shimizu Y, Iikuni S, Nakamoto Y, Ono M.
    Structure-Activity and Brain Kinetics Relationships of 18F Labeled Benzimidazopyridine Derivatives as Tau PET Tracers
    ACS Med. Chem. Lett. 12(2) 262-266 (2021)
  12. Shimizu Y, Nakai Y, Iikuni S, Watanabe H, Nakamoto Y, Ono M.
    Synthesis and Evaluation of Gallium-68-labeled Nitroimidazole Based Imaging Probes for PET Diagnosis of Tumor Hypoxia
    Ann. Nucl. Med. 35(3) 360-369 (2021)
  13. Nakashima K, Iikuni S, Okada Y, Watanabe H, Shimizu Y, Nakamoto Y, Ono M.
    Evaluation of 68Ga-labeled Imidazothiadiazole Sulfonamide Derivatives for PET Imaging of Carbonic Anhydrase-IX
    Nucl. Med. Biol. 93, 46-53 (2021)

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2020

  1. Iikuni S, Watanabe H, Shimizu Y, Nakamoto Y, Ono M.
    PET Imaging and Pharmacological Therapy Targeting Carbonic Anhydrase-IX High-expressing Tumors Using US2 Platform Based on Bivalent Ureidosulfonamide 
    PLoS One. 15(12) e0243327 (2020)
  2. Kaide S, Watanabe H, Shimizu Y, Iikuni S, Nakamoto Y, Hasegawa M, Itoh K, Ono M.
    Identification and Evaluation of Bisquinoline Scaffold as a New Candidate for α-Synuclein-PET Imaging
    ACS Chem. Neurosci. 11(24) 4254-4261 (2020)
  3. Watanabe H, Kawano K, Iikuni S, Shimizu Y, Ono M.
    Novel radiogallium-labeled pyridyl benzofuran derivative for detection of amylin aggregates in  pancreas
    Nucl. Med. Biol. 90-91 93-97 (2020)
  4. Ubukata S, Oishi N, Higashi T, Kagawa S, Yamauchi H, Okuyama C, Watanabe H, Ono M, Saji H,  Aso T, Murai T, Ueda K.
    Spatial patterns of amyloid deposition in patients with chronic focal or diffuse traumatic brain injury using 18F-FPYBF-2 PET
    Neuropsychiatr. Dis. Treat. 16 2719-2732 (2020)
  5. Iikuni S, Kitano A, Watanabe H, Shimizu Y, Ono M.
    Synthesis and Evaluation of Novel Technetium-99m-hydroxamamide Complex Based on Imidazothiadiazole Sulfonamide Targeting Carbonic Anhydrase-IX for Tumor Imaging
    Bioorg. Med. Chem. Lett. 30(22) 127596 (2020)
  6. Watanabe H, Sakai S, Iikuni S, Shimizu Y, Shirakawa H, Kaneko S, Ono M.
    Synthesis and Biological Evaluation of Radioiodinated 3-Phenylcoumarin Derivatives Targeting Myelin in Multiple Sclerosis
    Bioorg. Med. Chem. Lett. 30(24) 127562 (2020)
  7. Fuchigami T, Kawasaki M, Watanabe H, Nakagaki T, Nishi K, Sano K, Atarashi R, Nakaie M, Yoshida S, Ono M, Nishida N, Nakayama M.
    Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain
    Nucl. Med. Biol. 90-91, 41-48 (2020)
  8. Ding N, Sano K, Kanazaki K, Shimizu Y, Watanabe H, Namita T, Shiina T, Ono M, Saji H.
    Development of Gold Nanorods Conjugated with Radiolabeled Anti-human Epidermal Growth Factor Receptor 2 (HER2) Monoclonal Antibody as Single-photon Emission Computed Tomography/Photoacoustic Dual-imaging Probes Targeting HER2-positive Tumors
    Biol. Pharm. Bull. 43(12) 1859-1866 (2020)
  9. Ding N, Sano K, Kanazaki K, Shimizu Y, Watanabe H, Namita T, Shiina T, Ono M, Saji H.
    Sensitive Photoacoustic/Magnetic Resonance Dual Imaging Probe for Detection of Malignant Tumors
    J. Pharm. Sci. 109(10) 3153-3159 (2020)
  10. Iikuni S, Okada Y, Shimizu Y,  Watanabe H, Ono M.
    Synthesis and Evaluation of Indium-111-labeled Imidazothiadiazole Sulfonamide Derivative for Single Photon Emission Computed Tomography Imaging Targeting Carbonic Anhydrase-IX
    Bioorg. Med. Chem. Lett. 30(14) 127255 (2020)
  11. Ikeda H, Ishii A, Sano K, Chihara H, Arai D, Abekura Y, Nishi H, Ono M, Saji H, Miyamoto S.
    Activatable fluorescence imaging of macrophages in cerebral aneurysms using iron oxide nanoparticles conjugated with indocyanine green
    Front. Neurosci. 14 370 (2020)
  12. Watanabe H, Kawano K, Shimizu Y, Iikuni S, Nakamoto Y, Togashi K, Ono M.
    Development of Novel PET Imaging Probes for Detection of Amylin Aggregates in the Pancreas
    Mol. Pharm. 17(4) 1293-1299 (2020)
  13. Watanabe H, Tatsumi H, Kaide S, Shimizu Y, Iikuni S, Ono M.
    Structure-activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes
    ACS Med. Chem. Lett. 11(2) 120-126 (2020)
  14. Kawai R, Chiba S, Okuwaki K, Kanada R, Doi H, Ono M, Mochizuki Y, Okuno Y.
    Stabilization Mechanism for a Non-fibrillar Amyloid β Oligomer Based on Formation of a Hydrophobic Core Determined by Dissipative Particle Dynamics
    ACS Chem. Neurosci. 11(3) 385-394 (2020)

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2019

  1. Watanabe H, Matsushita N, Shimizu Y, Iikuni S, Nakamoto Y, Togashi K, Ono M.
    Synthesis and characterization of a novel 18F-labeled 2,5-diarylnicotinamide derivative targeting orexin 2 receptor
    Med. Chem. Commun. 10(12) 2126-2130
  2. Watanabe H, Itagaki F, Shimizu Y, Iikuni S, Ono M.
    Synthesis and evaluation of a radioiodinated BODIPY derivative as a thiol labeling agent
    J. Label. Compd. Radiopharm. 62(13) 885-891 (2019)
  3. Yagi Y, Kimura H, Okuda H, Ono M, Nakamoto Y, Togashi K, Saji H.
    Evaluation of [18F]pitavastatin as a positron emission tomography tracer for in vivo organic transporter polypeptide function
    Nucl. Med. Biol. 74-75 25-31 (2019)
  4. Mori D, Kimura H, Kawashima H, Yagi Y, Arimitsu K, Ono M, Saji H.
    Development of 99mTc Radiolabeled A85380 Derivatives Targeting Cerebral Nicotinic Acetylcholine Receptor: Novel Radiopharmaceutical Ligand 99mTc-A-YN-IDA-C4
    Bioorg. Med. Chem. 27(18) 4200-4210 (2019)
  5. Kaide S, Watanabe H, Shimizu Y, Tatsumi H, Iikuni S,  Nakamoto Y, Togashi K, Ihara M, Saji H, Ono M.
    18F-Labeled Benzimidazopyridine Derivatives for PET Imaging of Tau Pathology in Alzheimer’s Disease
    Bioorg. Med. Chem. 27(16) 3587-3594 (2019)
  6. Shimizu Y, Tanimura K, Iikuni S, Watanabe H, Saji H, Ono M.
    Development of technetium-99m-labeled BODIPY-based probes targeting lipid droplets for diagnosis of hyperlipidemia-related diseases
    Molecules 24(12) 2283 (2019)
  7. Watanabe H, Miki Y, Shimizu Y, Saji H, Ono M.
    Synthesis and evaluation of novel two-photon fluorescence probes for in vivo imaging of amylin aggregates in the pancreas
    Dyes. Pigm. 170 107615 (2019)
  8. Kimura H, Yagi Y, Mikamo M, Maeda K, Kagawa S, Arimitsu K, Higashi T, Nishii R, Ono M, Nakamoto Y, Togashi K, Kusuhara H, Saji H.
    Evaluation of Transporter-Mediated Hepatobiliary Transport of Newly Developed 18F-labeled Pitavastatin Derivative, PTV-F1, in Rats by PET Imaging
    Drug Metab. Pharmacokinet. 34(5), 317-324 (2019)
  9. Watanabe H, Fukui K, Shimizu Y, Idoko Y, Nakamoto Y, Togashi K, Saji H, Ono M.
    Synthesis and biological evaluation of F-18 labeled tetrahydroisoquinoline derivatives targeting orexin 1 receptor
    Bioorg. Med. Chem. Lett. 29(13) 1620-1623 (2019)
  10. Fuchigami T, Kawasaki M, Koyama R, Nakaie M, Nakagaki T, Sano K, Atarashi R, Yoshida S, Haratake M, Ono M, Nishida N, Nakayama M.
    Development of radioiodinated benzofuran derivatives for in vivo imaging of prion deposits in the brain
    ACS Infect. Dis. 5(12) 2003-2013
  11. Iikuni S, Tanimura K, Watanabe H, Shimizu Y, Saji H, Ono M.
    Development of 99mTc-Hydroxamamide Complex as Probe Targeting Carbonic Anhydrase IX
    Mol. Pharm. 16(4) 1489-1497 (2019)
  12. Yamauchi H, Kagawa S, Takahashi M, Oishi N, Ono M, Higashi T.
    Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease
    Neuroimage: Clinical 22 101762 (2019)
  13. Saga T, Nakamoto Y, Ishimori T, Inoue T, Shimizu Y, Kimura H, Akamatsu S, Goto T, Watanabe H, Kitaguchi K, Watanabe M, Ono M, Saji H, Ogawa O, Togashi K.
    Initial evaluation of PET/CT with 18F-FSU-880 targeting prostate-specific membrane antigen in prostate cancer patients
    Cancer Sci. 110(2) 742-750 (2019)

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2018

  1. Watanabe H, Yoshimura M, Sano K, Shimizu Y, Kaide S, Nakamoto Y, Togashi K, Ono M, Saji H.
    Characterization of Novel 18F-Labeled Phenoxymethylpyridine Derivatives as Amylin Imaging Probes
    Mol. Pharm. 15(12) 5574-5584 (2018)
  2. Watanabe H, Saji H, Ono M.
    Novel Fluorescence Probes based on the Chalcone Scaffold for In vitro Staining of β-Amyloid Plaques
    Bioorg. Med. Chem. Lett. 28(19) 3242-3246 (2018)
  3. Sano K, Kanada Y, Takahashi K, Ding N, Kanazaki K, Mukai T, Ono M, Saji H.
    Enhanced Delivery of Radiolabeled Polyoxazoline into Tumors via Self-Aggregation Under Hyperthermic Conditions
    Mol. Pharm. 15(9) 3997-4003 (2018)
  4. Kimura H, Yamauchi S, Kawashima H, Arimitsu K, Yagi Y, Nakamoto Y, Togashi K, Ono M, Saji H.
    Synthesis and evaluation of a [18F]formyl-Met-Leu-Phe derivative: A positron emission tomography imaging probe for bacterial infections
    Bioorg. Med. Chem. Lett. 28(17) 2949-2952 (2018)
  5. Kaide S, Ono M, Watanabe H, Shimizu Y, Nakamoto Y, Togashi K, Yamaguchi A, Hanaoka H, Saji H.
    Conversion of Iodine to Fluorine-18 Based on Iodinated Chalcone and Evaluation for β-Amyloid PET Imaging
    Bioorg. Med. Chem. 26(12) 3352-3358 (2018)
  6. Ikeda H, Ishii A, Sano K, Chihara H, Arai D, Abekura Y, Nishi H, Ono M, Saji H, Miyamoto S.
    Activatable fluorescence imaging of macrophages in atherosclerotic plaques using iron oxide nanoparticles conjugated with indocyanine green
    Atherosclerosis 275 1-10 (2018)
  7. Iikuni S, Ono M, Watanabe H, Shimizu Y, Sano K, Saji H.
    Cancer radiotheranostics targeting carbonic anhydrase-IX with 111In- and 90Y-labeled ureidosulfonamide scaffold for SPECT imaging and radionuclide-based therapy
    Theranostics 8(11) 2992-3006 (2018)
  8. Temma T, Kondo N, Yoda K, Nishigori K, Onoe S, Shiomi M, Ono M, Saji H.
    Comparison of 125I- and 111In-labeled peptide probes for in vivo detection of oxidized low density lipoprotein in atherosclerotic plaques
    Ann. Nucl. Med. 32(6) 410-416 (2018)
  9. Kaide S, Ono M, Watanabe H, Kitada A, Yoshimura M, Shimizu Y, Ihara M, Saji H.
    Structure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology
    ACS Med. Chem. Lett. 9(5) 478-483 (2018)
  10. Matsuoka D, Watanabe H, Shimizu Y, Kimura H, Yagi Y, Kawai R, Ono M, Saji H.
    Structure–activity relationships of succinimidyl-Cys-C(O)-Glu derivatives with different near-infrared fluorophores as optical imaging probes for prostate-specific membrane antigen
    Bioorg. Med. Chem. 26(9) 2291-2301 (2018)
  11. Nishii R, Higashi T, Kagawa S, Okuyama C, Kishibe Y, Takahashi M, Okina T, Suzuki N, Hasegawa H, Nagahama Y, Ishizu K, Oishi N, Kimura H, Watanabe H, Ono M, Saji H, Yamauchi H.
    18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer – Biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging –
    Ann. Nucl. Med. 32(4) 256-263 (2018)
  12. Higashi T, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Okina T, Suzuki N, Hasegawa H, Nagahama Y, Ishizu K, Oishi N, Kimura H, Watanabe H, Ono M, Saji H, Yamauchi H.
    18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer  – First experience in 61 volunteers and 55 patients with dementia –
    Ann. Nucl. Med. 32(3) 206-216 (2018)
  13. Makino A, Miyazaki A, Tomoike A, Kimura H, Arimitsu K, Hirata M, Ohmomo Y, Nishii R, Okazawa H, Kiyono Y, Ono M, Saji H.
    PET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy
    Bioorg. Med. Chem. 26(8) 1609-1613 (2018)
  14. Kawai R, Araki M, Yoshimura M, Kamiya N, Ono M, Saji H, Okuno Y.
    Core Binding Site of a Thioflavin-T-derived Imaging Probe on Amyloid β Fibrils Predicted by Computational Methods
    ACS Chem. Neurosci. 9(5) 957-966 (2018)
  15. Abe J, Isobe N, Mikata K, Nagahori H, Naito Y, Saji H, Ono M, Kawamura S.
    Flumioxazin metabolism in pregnant animals and cell-based protoporphyrinogen IX oxidase (PPO) inhibition assay of fetal metabolites in various animal species to elucidate the mechanism of the rat-specific developmental toxicity
    Toxicol. Appl. Pharmacol. 339 34-41(2018)
  16. Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M.
    Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice
    J. Drug. Target. 26(4) 373-381 (2018)
  17. Kimura H, Ogawa Y, Fujimoto H, Mukai E, Kawashima H, Arimitsu K, Toyoda K, Fujita N, Yagi Y, Hamamatsu K, Murakami T, Murakami A, Ono M, Nakamoto Y, Togashi K, Inagaki N, Saji H.
    Evaluation of 18F-Labeled Exendin(9-39) Derivatives Targeting Glucagon-like Peptide-1 Receptor for Pancreatic β-cell Imaging
    Bioorg. Med. Chem. 26(2) 463-469 (2018)

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2017

  1. Watanabe H, Ariyoshi T, Ozaki A, Ihara M, Ono M, Saji H.
    Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging α-synuclein aggregates
    Bioorg. Med. Chem. 25(24) 6398-6403 (2017)
  2. Saji H.
    In Vivo Molecular Imaging
    Biol. Pham. Bull. 40(10), 1605-1615 (2017) Review.
  3. Matsuoka D, Watanabe H, Shimizu Y, Kimura H, Ono M, Saji H.
    Synthesis and evaluation of a novel near-infrared fluorescent probe based on succinimidyl-Cys-C(O)-Glu that targets prostate-specific membrane antigen for optical imaging
    Bioorg. Med. Chem. Lett. 27(21) 4876-4880 (2017)
  4. Watanabe H.
    Development of SPECT probes for in vivo imaging of β-amyloid and tau aggregates in the Alzheimer’s disease brain
    YAKUGAKU ZASSHI 137(11), 1361-1365 (2017) Review.
  5. Kimura H, Fujita N, Kanbe K, Matsuda H, Watanabe H, Arimitsu K, Fujimoto H, Hamamatsu K, Yagi Y, Ono M, Inagaki N, Saji H.
    Synthesis and Biological Evaluation of an 111In-Labeled Exendin-4 Derivative as a SPECT probe for Imaging of Pancreatic β-cells
    Bioorg. Med. Chem. 25(20), 5772-5778 (2017)
  6. Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y.
    Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells
    Cancer Sci. 108(9), 1803-1810 (2017)
  7. Watanabe H, Ono M, Ariyoshi T, Katayanagi R, Saji H.
    Novel benzothiazole derivatives as fluorescent probes for detection of β-amyloid and α-synuclein aggregates
    ACS Chem. Neurosci. 8(8) 1656-1662 (2017)
  8. Ono M, Watanabe H, Ikehata Y, Ding N, Yoshimura M, Sano K, Saji H.
    Radioiodination of BODIPY and Its Application to a Nuclear and Optical Dual Functional Labeling Agent for Proteins and Peptides
    Sci. Rep. 7 3337 (2017)
  9. Sano K, Kanada Y, Kanazaki K, Ding N, Ono M, Saji H.
    Brachytherapy with Intratumoral Injections of Radiometal-labeled Polymers that Thermo-responsively Self-aggregate in Tumor Tissues
    J. Nucl. Med. 58(9) 1380-1385 (2017)
  10. Iikuni S, Ono M, Tanimura K, Watanabe H, Yoshimura M, Saji H.
    Synthesis and Biological Evaluation of Novel Technetium-99m-Labeled Phenylquinoxaline Derivatives as Single Photon Emission Computed Tomography Imaging Probes Targeting β-Amyloid Plaques in Alzheimer’s Disease
    RSC Adv. 7(33) 20582-20590 (2017)
  11. Kimura H, Okuda H, Ishiguro M, Arimitsu K, Makino A, Nishii R, Miyazaki A, Yagi Y, Watanabe H, Kawasaki I, Ono M, Saji H.
    18F-Labeled pyrido[3,4-d]pyrimidine as an effective probe for imaging of L858R-mutant epidermal growth factor receptor
    ACS Med. Chem. Lett. 8(4) 418-422 (2017)
  12. Hagimori M, Hatabe E, Sano K, Miyazaki H, Sasaki H, Saji H, Mukai T.
    An activatable fluorescent γ-polyglutamic acid complex for sentinel lymph node imaging
    Biol. Pharm. Bull. 40(3) 297-302 (2017)
  13. Suzuki S, Furuki T, Watanabe H, Ono M, Saji H.
    Investigating Tumor Accumulation of Nanoparticles Using Fluorescently Labeled Lactosomes
    ELCAS J. 2 43-47 (2017)
  14. Sano K, Ohashi M, Kanazaki K, Makino A, Ding N, Deguchi J, Kanada Y, Ono M, Saji H.
    Indocyanine green-labeled polysarcosine for in vivo photoacoustic tumor imaging
    Bioconjugate Chem. 28(4) 1024-1030 (2017)
  15. Kimura H, Matsuda H, Ogawa Y, Fujimoto H, Toyoda K, Fujita N, Arimitsu K, Hamamatsu K, Yagi Y, Ono M, Inagaki N, Saji H.
    Development of 111In-labeled Exendin(9-39) Derivatives for Single-Photon Emission Computed Tomography Imaging of Insulinoma
    Bioorg. Med. Chem. 25(4) 1406-1412 (2017)
  16. Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y.
    Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages
    J. Pharm. Sci. 106(1) 168-175 (2017)

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2016

  1. Iikuni S, Ono M, Watanabe H, Yoshimura M, Ishibashi-Ueda H, Ihara M, Saji H.
    Novel Bivalent 99mTc-Complex with N-Methyl-Substituted Hydroxamamide as Probe for Imaging of Cerebral Amyloid Angiopathy
    PLoS ONE, 11(9) e0163969 (2016)
  2. Ono M, Watanabe H, Kitada A, Matsumura K, Ihara M, Saji H.
    Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer’s Disease
    Sci. Rep. 6 34197 (2016)
  3. Kimura H, Yagi Y, Arimitsu K, Maeda K, Ikejiri K, Takano J, Kusuhara H, Kagawa S, Ono M, Sugiyama Y, Saji H.
    Radiosynthesis of Novel Pitavastatin Derivative ([18F]PTV-F1) as a Tracer for hepatic OATP Using a One-Pot Synthetic Procedure
    J. Labelled Compd. Radiopharm. 59(13) 565-575 (2016)
  4. Kanazaki K, Sano K, Makino A, Homma T, Ono M, Saji H.
    Polyoxazoline multivalently conjugated with indocyanine green for sensitive in vivo photoacoustic imaging of tumors
    Sci. Rep. 6 33798 (2016)
  5. Kimura H, Tomatsu K, Saiki H, Arimitsu K, Ono M, Kawashima H, Iwata R, Nakanishi H, Ozeki E, Kuge Y, Saji H.
    Continuous-flow synthesis of N-succinimidyl 4-[18F]fluorobenzoate using a single microfluidic chip
    PLoS ONE     11(7) e0159303 (2016)
  6. Harada N, Kimura H, Onoe S, Watanabe H, Matsuoka D, Arimitsu K, Ono M, Saji H.
    Synthesis and Biological Evaluation of Novel 18F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for Positron Emission Tomography of Prostate Cancer
    J. Nucl. Med.     57(12) 1978-1984 (2016)
  7. Ding N, Sano K, Kanazaki K, Ohashi M, Deguchi J, Kanada Y, Ono M, Saji H.
    In vivo HER2-Targeted Magnetic Resonance Tumor Imaging Using Iron Oxide Nanoparticles Conjugated with Anti-HER2 Fragment Antibody
    Mol. Imaging Biol.     18(6) 870-876 (2016)
  8. Yoshimura M, Ono M, Watanabe H, Kimura H, Saji H.
    Development of 99mTc-labeled Pyridyl Benzofuran Derivatives to Detect Pancreatic Amylin in Islet Amyloid Model Mice
    Bioconjugate Chem. 27(6) 1532-1539 (2016)
  9. Watanabe H, Kawasaki A, Sano K, Ono M, Saji H.
    Synthesis and evaluation of copper-64 labeled benzofuran derivatives targeting β-amyloid aggregates
    Bioorg. Med. Chem. 24(16) 3618-3623 (2016)
  10. Kurihara K, Ueda M, Hara I, Hara E, Sano K, Makino A, Ozeki E, Yamamoto F, Saji H, Togashi K, Kimura S.
    Inflammation-induced synergetic enhancement of nanoparticle treatments with DOXIL® and 90Y-Lactosome for orthotopic mammary tumor
    J. Nanopart. Res. 18 137 (2016)
  11. Nakamoto Y, Ishimori T, Sano K, Temma T, Ueda M, Saji H, Togashi K.
    Clinical efficacy of dual-phase scanning using 68Ga-DOTATOC-PET/CT in the detection of neuroendocrine tumours
    Clin. Radiol.     71 1069.e1-1069.e5 (2016)
  12. Iikuni S, Ono M, Watanabe H, Matsumura K, Yoshimura M, Kimura H, Ishibashi-Ueda H, Okamoto Y, Ihara M, Saji H.
    Imaging of Cerebral Amyloid Angiopathy with Bivalent 99mTc-Hydroxamamide Complexes
    Sci. Rep. 6 25990 (2016)
  13. Ono M, Doi Y, Watanabe H, Ihara M, Ozaki A, Saji H.
    Structure-Activity Relationships of Radioiodinated Diphenyl Derivatives with Different Conjugated Double Bonds as Ligands for α-Synuclein Aggregates
    RSC Adv. 6(50) 44305-44312 (2016)
  14. Ono M, Kitada A, Watanabe H, Miyazaki A, Kimura H, Saji H.
    Synthesis and Preliminary Characterization of Radioiodinated Benzofuran-3-yl-(indol-3-yl)maleimide Derivatives as Potential SPECT Imaging Probes for the Detection of Glycogen Synthase Kinase-3β (GSK-3β) in the Brain
    J. Labelled Comp. Radiopharm. 59(8) 317-321 (2016)
  15. Kimura H, Sampei S, Matsuoka D, Harada N, Watanabe H, Arimitsu K, Ono M, Saj H.
    Development of 99mTc-labeled Asymmetric Urea Derivatives that Target Prostate-Specific Membrane Antigen for Single-photon Emission Computed Tomography Imaging
    Bioorg. Med. Chem. 24(10) 2251-2256 (2016)
  16. Matsuura Y, Ueda M, Higaki Y, Watanabe K, Habara S, Kamino S, Saji H, Enomoto S.
    Noninvasive evaluation of nicotinic acetylcholine receptor availability in mouse brain using single-photon emission computed tomography with [123I]5IA
    Nucl. Med. Biol. 43(6) 372-378 (2016)
  17. Kanazaki K, Sano K, Makino A, Yamauchi F, Takahashi A, Homma T, Ono M, Saji H.
    Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging
    J. Control. Release 226 115-123 (2016)
  18. Abe T, Naruse M, Young W. F., Kobashi N, Doi Y, Izawa A, Akama K, Okumura Y, Ikenaga M, Kimura H, Saji H, Mukai K, Matsumoto H.
    A novel CYP11B2-specific imaging agent for detection of unilateral subtypes of primary aldosteronism
    J. Clin. Endocrinol. Metab. 101(3) 1008-1015 (2016)
  19. Makino A, Arai T, Hirata M, Ono M, Ohmomo Y, Saji H.
    Development of novel PET probes targeting phosphatidylinositol 3-kinase (PI3K) in tumors
    Nucl. Med. Biol. 43(1) 101-107 (2016)

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2015

  1. Kondo N, Temma T, Deguchi J, Sano K, Ono M, Saji H.
    Development of PEGylated peptide probes conjugated with 18F-labeled BODIPY for PET/optical imaging of MT1-MMP activity
    J. Control. Release 220 476-483 (2015)
  2. Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M.
    Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits
    Sci. Rep. 5 18440 (2015)
  3. Ueda M, Yamagami D, Watanabe K, Mori A, Kimura H, Sano K, Saji H, Ishikawa K, Hori M, Sakakita H, Ikehara Y, Enomoto S.
    Histological and Nuclear Medical Comparison of Inflammation After Hemostasis with Non-Thermal Plasma and Thermal Coagulation
    Plasma Process. Polym. 12 (12) 1338-1342 (2015)
  4. Watanabe H, Ono M, Saji H.
    In Vivo Fluorescence Imaging of β-Amyloid Plaques with Push-Pull Dimethylaminothiophene Derivatives
    Chem. Commun. 51 (96) 17124-17127 (2015)
  5. Matsumura K, Ono M, Kitada A, Watanabe H, Yoshimura M, Iikuni S, Kimura H, Okamoto Y, Ihara M, Saji H.
    Structure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents that Selectively Detect Neurofibrillary Tangles in Alzheimer’s Disease Brains
    J. Med. Chem. 58 (18) 7241-7257 (2015)
  6. Onoe S, Temma T, Kanazaki K, Ono M, Saji H.
    Development of phtostabilized asymmetrical cyanine dyes for in vivo photoacoustic imaging of tumors
    J. Biomed. Opt. 20 (9) 096006 (2015)
  7. Kondo N, Temma T, Shimizu Y, Ono M, Saj H.
    Radioiodinated peptidic imaging probes for in vivo detection of Membrane Type-1 Matrix Metalloproteinase in cancers
    Biol. Pharm. Bull. 38 (9) 1375-1382 (2015)
  8. Kanazaki K, Sano K, Makino A, Shimizu Y, Yamauchi F, Ogawa S, Ding N, Yano T, Temma T, Ono M, Saji H.
    Development of Anti-HER2 Fragment Antibody Conjugated to Iron Oxide Nanoparticles for in vivo HER2-Targeted Photoacoustic Tumor Imaging
    Nanomedicine: NBM 11 (8) 2051-2060 (2015)
  9. Fuchigami T, Ogawa A, Yamashita Y, Haratake M, Watanabe H, Ono M, Kawasaki M, Yoshida S, Nakayama M.
    Development of alkoxy styrylchromone derivatives for imaging of cerebral amyloid-β plaques with SPECT
    Bioorg. Med. Chem. Lett. 25 (16) 3363-3367 (2015)
  10. Sano K, Ohashi M, Kanazaki K, Ding N, Deguchi J, Kanada Y, Ono M, Saji H.
    In vivo photoacoustic imaging of cancer using indocyanine green-labeled monoclonal antibody targeting the epidermal growth factor receptor
    Biochem. Biophys. Res. Commun. 464 (3) 820-825 (2015)
  11. Kawashima H, Kimura H, Nakaya Y, Tomatsu K, Arimitsu K, Nakanishi H, Ozeki E, Kuge Y, Saji H.
    Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[11C]methylation with [11C]CH3I: Rapid Synthesis of [11C]Raclopride
    Chem. Pharm. Bull. 63 (9) 737-740 (2015)
  12. Saji H.
    Application of Radioisotopes for Theranostics, a Combination of Diagnostics and Therapy
    YAKUGAKU ZASSHI 135 (4) 551-556 (2015) Review.
  13. Nakamoto Y, Sano K, Ishimori T, Ueda M, Temma T, Saji H, Togashi K.
    Additional information gained by positron emission tomography with 68Ga-DOTATOC for suspected unknown primary or recurrent neuroendocrine tumor    s
    Ann. Nucl. Med. 29 (6) 512-518 (2015)
  14. Hagimori M, Temma T, Mizuyama N, Uto T, Yamaguchi Y, Tominaga Y, Mukai T, Saji H.
    A high-affinity fluorescent Zn2+ sensor improved by the suppression of pyridine-pyridone tautomerism and its application in living cells
    Sens. Act. B. 213 45-52 (2015)
  15. Yagi Y, Kimura H, Arimitsu K, Ono M, Maeda K, Kusuhara H, Kajimoto T, Sugiyama Y, Saji H.
    The synthesis of [18F]pitavastatin as a tracer for hOATP using the Suzuki coupling
    Org. Biomol. Chem. 13 1113-1121 (2015)
  16. Watanabe H, Ono M, Iikuni S, Kimura H, Okamoto Y, Ihara M, Saji H.
    Synthesis and biological evaluation of 123I-labeled pyridyl benzoxazole derivatives: novel β-amyloid imaging probes for single-photon emission computed tomography
    RSC Adv. 5 1009-1015 (2015)
  17. Temma T, Nishigori K, Onoe S, Sampei S, Kimura I, Ono M, Saji H.
    Radiofluorinated probe for PET imaging of fatty acid binding protein 4 in cancer
    Nucl. Med. Biol. 42 (2) 184-191 (2015)
  18. Ono M, Saji H.
    Recent Advances in Molecular Imaging Probes for β-Amyloid Plaques
    Med. Chem. Commun. 6 (3) 391-402 (2015) Review.
  19. Watanabe H, Ono M, Saji H.
    Novel PET/SPECT Probes for Imaging of Tau in Alzheimer’s Disease
    ScientificWorldJournal 2015 124192 (2015) Review.
  20. Morishita M, Takahashi Y, Nishikawa M, Sano K, Kato K, Yamashita T, Imai T, Saji H, Takakura Y.
    Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice.
    J. Pharm. Sci. 104 (2) 705-713 (2015)
  21. Hagimori M, Mizuyama N, Tominaga Y, Mukai T, Saji H.
    A low-molecular-weight fluorescent sensor with Zn2+ dependent bathochromic shift of emission wavelength and its imaging in living cells
    Dyes Pigm. 113 205-209 (2015)
  22. Ueda M, Hisada H, Temma T, Shimizu Y, Kimura H, Ono M, Nakamoto Y, Togashi K, Saji H.
    Gallium-68-labeled Anti-HER2 Single Chain Fv Fragment: Development and In Vivo Monitoring of HER2 Expression
    Mol. Imaging Biol. 17 (1) 102-110 (2015)

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2014

  1. Sozman, F., Kolemen, S., Kumada, H. O., Ono, M., Saji, H., Akkaya, E. U.
    Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques
    RSC Adv., 4 (92), 51032-51037. (2014)
  2. Watanabe, H., Ono, M., Iikuni, S., Yoshimura, M., Matsumura, K., Kimura, H., Saji, H.
    A 68Ga Complex Based on Benzofuran Scaffold for the Detection of β-Amyloid Plaques
    Bioorg. Med. Chem. Lett., 24 (20), 4834-4837. (2014)
  3. Ueda, M., Saji, H.
    Radiolabeled Probes Targeting Hypoxia-Inducible Factor-1-Active Tumor Microenvironments
    ScientificWorldJournal, 2014, 165461. (2014) Review.
  4. Yoshimura, M., Ono, M., Watanabe, H., Kimura, H., Saji, H.
    Feasibility of Amylin Imaging in Pancreatic Islets with β-Amyloid Imaging Probes
    Sci. Rep., 4, 6155. (2014)
  5. Temma, T., Onoe, S., Kanazaki, K., Ono, M., Saji, H.
    Preclinical evaluation of a novel cyanine dye for tumor imaging with in vivo photoacoustic imaging
    J. Biomed. Opt., 19 (9), 090501. (2014)
  6. Kanazaki, K., Sano, K., Makino, A., Takahashi, A., Deguchi, J., Ohashi, M., Temma, T., Ono, M., Saji, H.
    Development of human serum albumin conjugated with NIR dye for photoacoustic tumor imaging
    J. Biomed. Opt., 19 (9), 096002. (2014)
  7. Kimura, H., Yagi, Y., Ohneda, N., Odajima, H., Ono, M., Saji, H.
    Development of a resonant-type microwave reactor and its application to the synthesis of PET radiopharmaceuticals
    J. Label. Compd. Radiopharm., 57 (12), 680-686. (2014)
  8. Temma, T., Hanaoka, H., Yonezawa, A., Kondo, N., Sano, K., Sakamoto, T., Seiki, M., Ono, M., Saji, H.
    Investigation of a MMP-2 Activity-Dependent Anchoring Probe for Nuclear Imaging of Cancer
    PLoS ONE, 9 (7), e102180. (2014)
  9. Shimizu, Y., Temma, T., Hara, I., Makino, A., Kondo, N., Ozeki, EI., Ono, M., Saji, H.
    In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase With a Novel Activatable Near-Infrared Fluorescence Probe.
    Cancer Sci., 105（8), 1056-1062. (2014)
  10. Kimura, H., Matsuda, H., Fujimoto, H., Arimitsu, K., Toyoda, K., Mukai, E., Nakamura, H., Ogawa, Y., Takagi, M., Ono, M., Inagaki, N., Saji, H.
    Synthesis and evaluation of 18F-labeled mitiglinide derivatives as positron emission tomography tracers for β-cell imaging
    Bioorg. Med. Chem., 22 (13), 3270-3278. (2014)
  11. Takai, N., Tanaka, Y., Saji, H.
    Quantification of Small Molecule Drugs in Biological Tissue Sections by Imaging Mass Spectrometry Using Surrogate Tissue-Based Calibration Standards
    Mass Spectrom., 3 (1), A0025. (2014)
  12. Nishigori, K., Temma, T., Onoe, S., Sampei, S., Kimura, I., Ono, M., Saji, H.
    Development of a radioiodinated triazolopyrimidine probe for nuclear medical imaging of fatty acid binding protein-4
    PLoS ONE, 9 (4), e94668. (2014)
  13. Iikuni, S., Ono, M., Watanabe, H., Matsumura, K., Yoshimura, M., Harada, N., Kimura, H., Nakayama, M., Saji, H.
    Enhancement of Binding Affinity for Amyloid Aggregates by Multivalent Interactions of 99mTc-Hydroxamamide Complexes
    Mol. Pharmaceutics, 11 (4), 1132-1139. (2014)
  14. Onoe, S., Temma, T., Shimizu, Y., Ono, M., Saji, H.
    Investigation of Cyanine Dyes for In Vivo Optical Imaging of Altered Mitochondrial Membrane Potential in Tumors
    Cancer Medicine, 3 (4), 775-786. (2014)
  15. Ueda, M., Fukushima, T., Ogawa, K., Kimura, H., Ono, M., Yamaguchi, T., Ikehara, Y., Saji, H.
    Synthesis and evaluation of a radioiodinated peptide probe targeting αvβ6 integrin for the detection of pancreatic ductal adenocarcinoma
    Biochem. Biophys. Res. Commun., 445 (3), 661-666. (2014)
  16. Cui, M., Ono, M., Watanabe, H., Kimura, H., Liu, B., Saji, H.
    Smart Near-Infrared Fluorescence Probes with Donor-Acceptor Structure for in vivo Detection of β-Amyloid Deposits
    J. Am. Chem. Soc., 136 (9), 3388-3394. (2014)
  17. Sano, K., Masuda, R., Hisada, H., Oishi, S., Shimokawa, K., Ono, M., Fujii, N., Saji, H., Mukai, T.
    A radiogallium-DOTA-based bivalent peptidic ligand targeting a chemokine receptor, CXCR4, for tumor imaging
    Bioorg. Med. Chem. Lett., 24 (5), 1386-1388. (2014)
  18. Watanabe, H., Ono, M., Kimura, H., Matsumura, K., Yoshimura, M., Iikuni, S., Okamoto, Y., Ihara, M., Takahashi, R., Saji, H.
    Novel Radioiodinated 1,3,4-Oxadiazole Derivatives with Improved in Vivo Properties for SPECT Imaging of β-Amyloid Plaques
    Med. Chem. Commun., 5 (1), 82-85. (2014)
  19. Kimura, H., Kawai, T., Hamashima, Y., Kawashima, H., Miura, K., Nakaya, Y., Hirasawa, M., Arimitsu, K., Kajimoto, T., Ohmomo, Y., Ono, M., Node, M., Saji, H.
    Synthesis and Evaluation of (−)- and (+)-[11C]Galanthamine as PET Tracers for Cerebral Acetylcholinesterase Imaging
    Bioorg. Med. Chem., 22 (1), 285-291. (2014)
  20. Shimizu, Y., Temma, T., Hara, I., Makino, A., Yamahara, R., Ozeki, E.-i., Ono, M., Saji, H.
    Micelle-based activatable probe for in vivo near-infrared optical imaging of cancer biomolecules
    Nanomedicine: NBM, 10 (1), 187-195. (2014)

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2013

  1. Harada, N., Kimura, H., Ono, M., Saji, H.
    Preparation of Asymmetric Urea Derivatives that Target Prostate-Specific Membrane Antigen for SPECT Imaging
    (2013) Journal of Medicinal Chemistry, 56 (20), pp 7890-7901
  2. Ono, M., Cheng, Y., Kimura, H., Watanabe, H., Matsumura, K., Yoshimura, M., Iikuni, S., Okamoto, Y., Ihara, M., Takahashi, R., Saji, H.
    Development of Novel 123I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer’s Disease
    (2013) PLOS ONE, 8 (9), e74104
  3. Arimitsu, K., Kimura, H., Kajimoto, T., Ono, M., Ohmomo, Y., Yamashita, M., Node, M., Saji, H.
    Novel design and synthesis of a radioiodinated glycolipid analog as an acceptor substrate for N-acetylglucosaminyltransferase V
    (2013) Journal of Labelled Compounds and Radiopharmaceuticals, 56 (11), pp. 562-572
  4. Ueda, M., Ogawa, K., Miyano, A., Ono, M., Kizaka-Kondoh, S., Saji, H.
    Development of an Oxygen-Sensitive Degradable Peptide Probe for the Imaging of Hypoxia-Inducible Factor-1-Active Regions in Tumors
    (2013) Molecular Imaging and Biology, 15 (6), PP. 713-721
  5. Yoshimura, M., Ono, M., Matsumura, K., Watanabe, H., Kimura, H., Cui, M., Nakamoto, Y., Togashi, K., Okamoto, Y., Ihara, M., Takahashi, R., Saji, H.
    Structure-activity relationships and in vivo evaluation of quinoxaline derivatives for PET imaging of β-amyloid plaques
    (2013) ACS Medicinal Chemistry Letters, 4 (7), pp. 596-600.
  6. Kawai, T., Kawashima, H., Kuge, Y., Saji, H.
    Synthesis and evaluation of 11C-labeled naphthalene derivative as a novel non-peptidergic probe for the β-secretase (BACE1) imaging in Alzheimer’s disease brain
    (2013) Nuclear Medicine and Biology, 40 (5), pp. 705-709.
  7. Watanabe, H., Ono, M., Matsumura, K., Yoshimura, M., Kimura, H., Saji, H.
    Molecular imaging of β-amyloid plaques with near-infrared boron dipyrromethane (BODIPY)-based fluorescent probes
    (2013) Molecular Imaging, 12 (5), pp. 338-347.
  8. Matsumura, K., Ono, M., Yoshimura, M., Kimura, H., Watanabe, H., Okamoto, Y., Ihara, M., Takahashi, R., Saji, H.
    Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer’s disease
    (2013) Bioorganic and Medicinal Chemistry, 21 (11), pp. 3356-3362.
  9. Hagimori, M., Uto, T., Mizuyama, N., Temma, T., Yamaguchi, Y., Tominaga, Y., Saji, H.
    Fluorescence ON/OFF switching Zn2+ sensor based on pyridine-pyridone scaffold
    (2013) Sensors and Actuators, B: Chemical, 181, pp. 823-828.
  10. Sano, K., Okada, M., Hisada, H., Shimokawa, K., Saji, H., Maeda, M., Mukai, T.
    In vivo evaluation of a radiogallium-labeled bifunctional radiopharmaceutical, Ga-DOTA-MN2, for hypoxic tumor imaging
    (2013) Biological and Pharmaceutical Bulletin, 36(4), pp. 602-608.
  11. Kondo, N., Temma, T., Shimizu, Y., Watanabe, H., Higano, K., Takagi, Y., Ono, M., Saji, H.
    Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers
    (2013) Cancer Science, 104 (4), pp. 495-501.
  12. Kadowaki, S., Munekane, M., Kitamura, Y., Hiromura, M., Kamino, S., Yoshikawa, Y., Saji, H., Enomoto, S.
    Development of New Zinc Dithiosemicarbazone Complex for Use as Oral Antidiabetic Agent
    (2013) Biological Trace Element Research, 154 (1), pp. 111-119.
  13. Takai, N., Tanaka, Y., Watanabe, A., Saji, H.
    Quantitative imaging of a therapeutic peptide in biological tissue sections by MALDI MS
    (2013) Bioanalysis, 5 (5), pp. 603-612.
  14. Li, Z., Cui, M., Dai, J., Wang, X., Yu, P., Yang, Y., Jia, J., Fu, H., Ono, M., Jia, H., Saji, H., Liu, B.
    Novel cyclopentadienyl tricarbonyl complexes of 99mTc mimicking chalcone as potential single-photon emission computed tomography imaging probes for β-amyloid plaques in brain
    (2013) Journal of Medicinal Chemistry, 56 (2), pp. 471-482.
  15. Nishigori, K., Temma, T., Yoda, K., Onoe, S., Kondo, N., Shiomi, M., Ono, M., Saji, H.
    Radioiodinated peptide probe for selective detection of oxidized low density lipoprotein in atherosclerotic plaques
    (2013) Nuclear Medicine and Biology, 40 (1), pp. 97-103.

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