1. Physico-chemical and antitumor characteristics
of high molecular weight prodrugs of mitomycin C.
Akira
Kato, Yoshinobu Takakura, Mitsuru Hashida, Toshikiro Kimura, and Hitoshi Sezaki
Chemical
and Pharmaceutical Bulletin, 30, 2951-2957 (1982)
2. Regeneration
characteristics of mitomycin C-dextran conjugate in relation to its activity.
Mitsuru
Hashida, Yoshinobu Takakura, Satoshi Matsumoto, Hitoshi Sasaki, Akira Kato, Takumi
Kojima, Shozo Muranishi, and Hitoshi Sezaki
Chemical
and Pharmaceutical Bulletin, 31, 2055-2063 (1983)
3. Enhanced
lymphatic delivery of mitomycin C conjugated with dextran.
Yoshinobu
Takakura, Satoshi Matsumoto, Mitsuru Hashida, and Hitoshi Sezaki
Cancer
Research, 44, 2505-2510 (1984)
4. Antitumor
activity of lipophilic prodrugs of mitomycin C entrapped in liposome or O/W
emulsion.
Hitoshi
Sasaki, Yoshinobu Takakura, Mitsuru Hashida, Toshikiro Kimura, and Hitoshi
Sezaki
Journal
of Pharmacobio-Dynamics, 7, 120-130 (1984)
5. Disposition
and pharmacokinetics of a polymeric prodrug of mitomycin C, mitomycin C-dextran
conjugate, in the rat.
Mitsuru
Hashida, Akira Kato, Yoshinobu Takakura, and Hitoshi Sezaki
Drug
Metabolism and Disposition, 12, 492-499 (1984)
6. Physicochemical
and antitumor characteristics of some polyamino acid prodrugs of mitomycin C.
C.F.
Roos, Satoshi Matsumoto, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi
Sezaki
International
Journal of Pharmaceutics, 22, 75-87 (1984)
7. Urinary
excretion characteristics of a polymeric prodrug of mitomycin C, mitomycin
C-dextran conjugate.
Yoshinobu
Takakura, Akira Kato, Mitsuru Hashida, Kazuo Honda, Akira Arimoto, Kisaku
Satomura, and Hitoshi Sazaki
Journal
of Pharmacobio-Dynamics, 8, 357-364 (1985)
8. Plasma
disposition and in vivo and in vitro antitumor activities of mitomycin
C-dextran conjugate in relation to the mode of action.
Satoshi
Matsumoto, Yoshiko Arase, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi
Sezaki
Chemical
and Pharmaceutical Bulletin, 33, 2941-2947 (1985)
9. Fate
of lipid and encapsulated drug after intramuscular administration ofliposomes
prepared by the freeze-thawing method in rats.
Takashi
Ohsawa, Yasuhisa Matsukawa, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi
Sezaki
Chemical
and Pharmaceutical Bulletin, 33, 5013-5022 (1985)
10. Absorption
characteristics of macromolecular prodrugs of mitomycin C following
intramuscular administration.
Yoshinobu
Takakura, Kuni Mori, Mitsuru Hashida, and Hitoshi Sezaki
Chemical
and Pharmaceutical Bulletin, 34, 1775-1783 (1986)
11. Cellular
interaction and in vitro antitumor activity of mitomycin C-dextran conjugate.
Satoshi
Matsumoto, Atsuko Yamamoto, Yoshinobu Takakura, Nobuhiko Tanigawa, Mitsuru
Hashida, and Hitoshi Sezaki
Cancer
Research, 46, 4463-4468 (1986)
12. Development
of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with
anionic charge.I: Physicochemical characteristics and in vivo and in vitro
antitumor activities.
Yoshinobu
Takakura, Masako Kitajima, Satoshi Matsumoto, Mitsuru Hashida, and Hitoshi
Sezaki
International
Journal of Pharmaceutics, 37, 135-143 (1987)
13. Development
of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with
anionic charge.II: Disposition and pharmacokinetics following intravenous, and
intramuscular administration.
Yoshinobu
Takakura, Ryo Atsumi, Mitsuru Hashida, and Hitoshi Sezaki
International
Journal of Pharmaceutics, 37, 145-154 (1987)
14. Cellular
interaction and in vitro antitumor effect of various mitomycin C prodrugs in
mitomycin C-resistant L1210 leukemia cell lines.
Satoshi
Matsumoto, Tsunehiko Shigeoka, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi
Sezaki
Chemical
and Pharmaceutical Bulletin, 35, 3792-3799 (1987)
15. Disposition
and tumor localization of mitomycin C-dextran conjugates in mice.
Yoshinobu
Takakura, Akira Takagi, Mitsuru Hashida, and Hitoshi Sezaki
Pharmaceutical
Research, 4, 293-300 (1987)
16. Disposition
characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing
muscles of rabbits.
Ryo
Atsumi, Kaori Endo, Toshiyuki Kakutani, Yoshinobu Takakura, Mitsuru Hashida,
and Hitoshi Sezaki
Cancer
Research, 47, 5546-5551 (1987)
17. The
accumulation mechanism of cationic mitomycin C-dextran conjugates in the liver:
In vivo cellular localization and in vitro interaction with hepatocytes.
Sachi
Nakane, Satoshi Matsumoto, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi
Sezaki
Journal
of Pharmacy and Pharmacology, 40(1), 1-6 (1988)
18. Control
of biopharmaceutical properties by dextran conjugates.
Hitoshi
Sezaki, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Bioactive and Compatible Polymers, 3(1), 81-85 (1988)
19. Characterization
of a lipophilic prodrug of 5-fluorouracil with a cholesterol promoiety and its
application to liposomes.
Mitsuru
Hashida, Kimihiko Sato, Yoshinobu Takakura, and Hitoshi Sezaki
Chemical
and Pharmaceutical Bulletin, 36(8), 3186-3189 (1988)
高倉喜信，藤田卓也，橋田 充，瀬崎 仁
Drug
Delivery System, 3(3), 405-409 (1988)
21. Control
of pharmaceutical properties of soybean trypsin inhibitor by conjugation with
dextran I: Synthesis and characterization.
Yoshinobu
Takakura, Yoko Kaneko, Takuya Fujita, Mitsuru Hashida, Hiroshi Maeda, and
Hitoshi Sezaki
Journal
of Pharmaceutical Sciences, 78(2), 117-121 (1989)
22. Control
of pharmaceutical properties of soybean trypsin inhibitor by conjugation with
dextran II: Biopharmaceutical and pharmacological properties.
Yoshinobu
Takakura, Takuya Fujita, Mitsuru Hashida, Hiroshi Maeda, and Hitoshi Sezaki
Journal
of Pharmaceutical Sciences, 78(3), 219-222 (1989)
23. Disposition
of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the
perfused rat liver.
Kimihiko
Sato, Kazue Itakura, Koyo Nishida, Yoshinobu Takakura, Mitsuru Hashida, and
Hitoshi Sezaki
Journal
of Pharmaceutical Sciences, 78(1), 11-16 (1989)
24. デキストラン誘導体を用いた分子構造修飾によるウリカーゼの体内挙動制御
高倉喜信，藤田卓也，安田芳久，橋田 充，瀬崎 仁
Drug
Delivery System, 4(2), 84-87 (1989)
25. タンパク質修飾素材としてのポリエチレングリコールとデキストランの比較
高倉喜信，藤田卓也，橋田 充，瀬崎 仁
Drug
Delivery System, 4(2), 123-124 (1989)
26. Physicochemical
properties and antitumor activities of polymeric prodrugs of mitomycin C with
different regeneration rates.
Yoshinobu
Takakura, Satoshi Matsumoto, Mitsuru Hashida, and Hitoshi Sezaki
Journal
of Controlled Release, 10(1), 97-105 (1989)
27. Alteration
of biopharmaceutical properties of drugs by their conjugation with
water-soluble macromolecules: Uricase-dextran conjugate.
Takuya
Fujita, Yoshihisa Yasuda, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi
Sezaki
Journal
of Controlled Release, 11(1-3), 149-156 (1990)
28. Disposition
of anticancer drugs after bolous arterial administration in a tissue-isolated
tumor perfusion system.
Kazuhiro
Ohkouchi, Hirofumi Imoto, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi
Sezaki
Cancer
Research, 50, 1640-1644 (1990)
29. 単離腫瘍潅流実験系を利用した薬物移行特性評価法の開発
井本博文，大河内一宏，高倉喜信，橋田 充，瀬崎 仁
Drug
Delivery System, 5(2), 77-81 (1990)
30. Disposition
characteristics of macromolecules in tumor-bearing mice.
Yoshinobu
Takakura, Takuya Fujita, Mitsuru Hashida, and Hitoshi Sezaki
Pharmaceutical
Research, 7(4), 339-346 (1990)
31. Biochemical
and biopharmaceutical properties of macromolecular conjugates of uricase with
dextran and polyethylene glycol.
Yoshihisa
Yasuda, Takuya Fujita, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi Sezaki
Chemical
and Pharmaceutical Bulletin, 38(7), 2053-2056 (1990)
32. Biliary
excretion of mitomycin C dextran conjugates in relation to physicochemical
characteristics of carrier dextran.
Mitsuru
Hashida, Ryo Atsumi, Koyo Nishida, Sachi Nakane, Yoshinobu Takakura, and
Hitoshi Sezaki
Journal
of Pharmacobio-Dynamics, 13(7), 441-447 (1990)
33. Effect
of electric charge on the hepatic uptake of macromolecules in the rat liver.
Koyo Nishida, Chiaki Tonegawa, Sachi Nakane, Yoshinobu Takakura,
Mitsuru Hashida, and Hitoshi Sezaki
International
Journal of Pharmaceutics, 65(1), 7-17 (1990)
34. Tumor
localization and in vivo antitumor activity of the immunoconjugate composed of
anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate.
Akinori
Noguchi, Toshio Takahashi, Toshiharu Yamaguchi, Kazuya Kitamura, Yoshinobu
Takakura, Mitsuru Hashida, and Hitoshi Sezaki
Japanese
Journal of Cancer Research, 82(2), 219-226 (1991)
35. Hepatic
disposition characteristics of electrically charged macromolecules in rat in
vivo and in the perfused liver.
Koyo
Nishida, Kiyoshi Mihara, Toichi Takino, Sachi Nakane, Yoshinobu Takakura,
Mitsuru Hashida, and Hitoshi Sezaki
Pharmaceutical
Research, 8(4), 437-444 (1991)
36. 新しい合成法による抗ヒト大腸癌モノクローナル抗体
A7 とマイトマイシンＣ－デキストラン結合体の複合体の合成
野口明則，高橋俊雄，北村和也，山口俊晴，高倉喜信，橋田 充，瀬崎 仁
Drug
Delivery System, 6(3), 171-175 (1991)
37. Hepatic
disposition characteristics of 111In-labeled lactosaminated bovine serum albumin
in rats.
Koyo
Nishida, Yukiko Eguchi, Toichi Takino, Yoshinobu Takakura, Mitsuru Hashida, and
Hitoshi Sezaki
Pharmaceutical
Research, 8(10), 1253-1257 (1991)
38. Tissue
distribution of 111In-labeled uricase conjugated with charged dextrans and polyethylene
glycol.
Takuya
Fujita, Yoshihisa Yasuda, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi
Sezaki
Journal
of Pharmacobio-Dynamics, 14(11), 623-629 (1991)
39. Hexose
uptake in primary cultures of bovine brain microvessel endothelial cells. I. Basic
characteristics and effects of D-glucose and insulin.
Yoshinobu
Takakura, S.L. Kuentzel, T.J. Raub, A. Davis, S.A. Baldwin, and R.T. Borchardt
Biochimica
et Biophysica Acta, 1070(1), 1-10 (1991)
conditioned
media from astroglial and glioma cells.
Yoshinobu
Takakura, A.M. Trammel, S.L. Kuentzel, T.J. Raub, A. Davis, S.A. Baldwin, and
R.T. Borchardt
Biochimica
et Biophysica Acta, 1070(1), 11-19 (1991)
41. Permeability
of macromolecules in cultured endothelial and tumor cell layers on microporous
membranes.
Masaaki
Masegi, Naomi Wakabayashi, Kazuyoshi Sagara, Yoshinori Teramura, Akira
Yamamoto, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi Sezaki
International
Journal of Pharmaceutics, 78(2/3), 103-113 (1992)
42. Demonstration
of the receptor-mediated hepatic uptake of dextran in mice.
Makiya
Nishikawa, Fumiyoshi Yamashita, Yoshinobu Takakura, Mitsuru Hashida, and
Hitoshi Sezaki
Journal
of Pharmacy and Pharmacology, 44(5), 396-401 (1992)
43. Preparation
and properties of the immunoconjugate composed of anti-human colon cancer
monoclonal antibody and mitomycin C-dextran conjugate.
Akinori
Noguchi, Toshio Takahashi, Toshiharu Yamaguchi, Kazuya Kitamura, Yoshinobu
Takakura, Mitsuru Hashida, and Hitoshi Sezaki
Bioconjugate
Chemistry, 3, 132-137 (1992)
44. Disposition
characteristics of macromolecules in the perfused tissue-isolated tumor
preparation.
Hirofumi
Imoto, Yumi Sakamura, Kazuhiro Ohkouchi, Ryo Atsumi, Yoshinobu Takakura,
Hitoshi Sezaki, and Mitsuru Hashida
Cancer
Research, 52(16), 4396-4401 (1992)
45. Therapeutic
effects of superoxide dismutase derivatives modified with mono- or
polysaccharides on hepatic injury induced by ischemia/reperfusion.
Takuya
Fujita, Hisao Furitsu, Makiya Nishikawa, Yoshinobu Takakura, Hitoshi Sezaki,
and Mitsuru Hashida
Biochemical
and Biophysical Research Communications, 189(1), 191-196 (1992)
46. Targeted
delivery of human recombinant superoxide dismutase by chemical modification
with mono- and polysaccharide derivatives.
Takuya
Fujita, Makiya Nishikawa, Chieko Tamaki, Yoshinobu Takakura, Mitsuru Hashida,
and Hitoshi Sezaki
Journal
of Pharmacology and Experimental Therapeutics, 263(3), 971-978 (1992)
47. Disposition
characteristics of model macromolecules in the perfused rat kidney.
Kiyoshi
Mihara, Mihoko Mori, Takami Hojo, Yoshinobu Takakura, Hitoshi Sezaki, and
Mitsuru Hashida
Biological
and Pharmaceutical Bulletin, 16(2), 158-162 (1993)
48. 各種修飾
superoxide dismutase の肝障害抑制効果
振津尚夫，高倉喜信，橋田 充，瀬崎 仁
Drug
Delivery System, 8(1), 49-52 (1993)
49. Disposition
characteristics of protein drugs in the perfused rat kidney.
Kiyoshi
Mihara, Takami Hojo, Makoto Fujikawa, Yoshinobu Takakura, Hitoshi Sezaki, and
Mitsuru Hashida
Pharmaceutical
Research, 10(6), 823-827 (1993)
50. Controlled
biodistribution of highly lipophilic drugs with various parenteral
formulations.
Toichi
Takino, Chisato Nakajima, Yoshinobu Takakura, Hitoshi Sezaki, and Mitsuru
Hashida
Journal
of Drug Targeting, 1(2), 117-124 (1993)
51. Synthesis
and pharmacokinetics of a new liver-specific carrier, glycosylated
carboxymethyl-dextran, and its application to drug targeting.
Makiya
Nishikawa, Akiko Kamijo, Takuya Fujita, Yoshinobu Takakura, Hitoshi Sezaki, and
Mitsuru Hashida
Pharmaceutical
Research, 10(9), 1253-1261 (1993)
52. 機構論に基づく吸収促進剤適用の最適化の試み
山下富義，小山靖夫，坂東博人，高倉喜信，橋田 充
Drug
Delivery System, 8(4), 243-250 (1993)
53. Supecific
uptake of succinylated proteins via a scavenger receptor-mediated mechanism in
cultuled brain microvessel endothelial cells.
Hideaki
Tokuda, Sada Masuda, Yoshinobu Takakura, Hitoshi Sezaki, and Mitsuru Hashida
Biochemical
and Biophysical Research Communications, 196(1), 18-24 (1993)
54. Long
circulating emulsion carrier systems for highly lipophilic drugs.
Toichi
Takino, Kiyoshi Konishi, Yoshinobu Takakura, and Mitsuru Hashida
Biological
and Pharmaceutical Bulletin, 17(1), 121-125 (1994)
55. Targeting
delivery of protein drugs by chemical modification.
Mitsuru
Hashida, Makiya Nishikawa, Fumiyoshi Yamashita, and Yoshinobu Takakura
Drug
Development and Industrial Pharmacy, 20(4), 581-590 (1994)
56. Manipulation
of renal disposition of human recombinant superoxide dismutase by chemical modification.
Kiyoshi
Mihara, Kenzo Sawai, Yoshinobu Takakura, and Mitsuru Hashida
Biological
and Pharmaceutical Bulletin, 17(2), 296-301 (1994)
57. Comparative
analysis of percutaneous absorption enhancement by d-Limonene and oleic acid
based on a skin diffusion model.
Yasuo
Koyama, Hiroto Bando, Fumiyoshi Yamashita, Yoshinobu Takakura, Hitoshi Sezaki,
and Mitsuru Hashida
Pharmaceutical
Research, 11(3), 377-383 (1994)
58. In
vivo and in vitro analysis of skin penetration enhancement based on a two-layer
diffusion model with polar and nonpolar routes in the stratum corneum.
Fumiyoshi
Yamashita, Hiroto Bando, Yasuo Koyama, Shuji Kitagawa, Yoshinobu Takakura, and
Mitsuru Hashida
Pharmaceutical
Research, 11(2), 185-191 (1994)
Yoshinobu
Takakura, Sada Masuda, Hideaki Tokuda, Makiya Nishikawa, and Mitsuru Hashida
Biochemical
Pharmacology, 47(5), 853-858 (1994)
60. Control
of the disposition profiles of proteins in the kidney via chemical
modification.
Yoshinobu
Takakura, Kiyoshi Mihara, and Mitsuru Hashida
Journal
of Controlled Release, 28, 111-119 (1994)
61. Pharmacokinetics
of succinylated proteins and dextran sulfate in mice: implications for hepatic
targeting of protein drugs by direct succinylation via scavenger receptors.
Yoshinobu
Takakura, Takuya Fujita, Hisao Furitsu, Makiya Nishikawa, Hitoshi Sezaki, and
Mitsuru Hashida
International
Journal of Pharmaceutics, 105, 19-29 (1994)
62. Control
of in vivo fate of albumin derivatives utilizing combined chemical
modification.
Takuya
Fujita, Makiya Nishikawa, Yoshito Ohtsubo, Junko Ohno, Yoshinobu Takakura,
Hitoshi Sezaki, and Mitsuru Hashida
Journal
of Drug Targeting, 2(2), 157-165 (1994)
63. Pharmacokinetics
in design of polymeric drug delivery systems.
Mitsuru
Hashida, and Yoshinobu Takakura
Journal
of Controlled Release, 31(2), 163-171 (1994)
64. 糖修飾による蛋白質の肝臓特異的ターゲティングにおける分子サイズの影響
西川元也，平林英樹，高倉喜信，橋田 充
Drug
Delivery System, 9(3), 173-178 (1994)
65. Improvement
of the pulmonary absorption of (asu1,7)-eel calcitonin by various
protease inhibitors in rats.
Takahiro
Morita, Akira Yamamoto, Yoshinobu Takakura, Mitsuru Hashida, and Hitoshi Sezaki
Pharmaceutical
Research, 11(6), 909-913 (1994)
66. Skin
penetration enhancement of acyclovir by prodrug-enhancer combination.
Hiroto
Bando, Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru Hashida
Biological
and Pharmaceutical Bulletin, 17(8), 1141-1143 (1994)
67. Improvement
of therapeutic effect of human recombinant superoxide dismutase on ischemic
acute renal failure in the rat via cationization and conjugation with
polyethylene glycol.
Kiyoshi
Mihara, Yoshikazu Oka, Kenzo Sawai, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Drug Targeting, 2, 317-321 (1994)
68. Pharmacokinetic
disposition analysis of lipophilic drugs injected with various lipid carriers
in the single-pass rat liver perfusion system.
Toichi
Takino, Eiko Nagahama, Toshiyuki Sakaeda(ne Kakutani), Fumiyoshi Yamashita,
Yoshinobu Takakura, and Mitsuru Hashida
International
Journal of Pharmaceutics, 114, 43-54 (1995)
69. Design
for cell-specific targeting of proteins utilizing sugar-recognition mechanism: effect
of molecular weight of proteins on targeting efficiency.
Makiya
Nishikawa, Hideki Hirabayashi, Yoshinobu Takakura, and Mitsuru Hashida
Pharmaceutical
Research, 12(2), 209-214 (1995)
70. Galactosylated
proteins are recognized by the liver according to the surface density of
galactose moieties.
Makiya
Nishikawa, Chizu Miyazaki, Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru
Hashida
American
Journal of Physiology: Gastrointestinal and Liver Physiology, 268, G849-G856
(1995)
71. Analysis
of in vivo skin penetration enhancement by oleic acid based on a two-layer
diffusion model with polar and nonpolar routes in the stratum corneum.
Fumiyoshi
Yamashita, Yasuo Koyama, Megumi Kitano, Yoshinobu Takakura, and Mitsuru Hashida
International
Journal of Pharmaceutics, 117, 173-179 (1995)
72. In
vivo disposition characteristics of plasmid DNA complexed with cationic
liposomes.
Ram
I. Mahato, Kenji Kawabata, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Drug Targeting, 3, 149-157 (1995)
73. The
fate of plasmid DNA after intravenous injection in mice: Involvement of
scavenger receptors in its hepatic uptake.
Kenji
Kawabata, Yoshinobu Takakura, and Mitsuru Hashida
Pharmaceutical
Research, 12(6), 825-830 (1995)
74. Stability
and pharmacokinetic characteristics of oligonucleotides modified at terminal
linkages in mice.
Takenori
Miyao, Yoshinobu Takakura, Taishin Akiyama, Fumio Yoneda, Hitoshi Sezaki, and
Mitsuru Hashida
Antisense
Research and Development, 5, 115-121 (1995)
75. In
vitro cytotoxicity of macromolecules in different cell culture systems.
Suthummar
Choksakulnimitr, Sada Masuda, Hideaki Tokuda, Yoshinobu Takakura, and Mitsuru
Hashida
Journal
of Controlled Release, 34(3), 233-241(1995)
76. 脂質分散系製剤による脂溶性薬物の体内動態制御
滝野十一，是枝範子，山下富義，高倉喜信，橋田 充
Drug
Delivery System, 10(3), 153-158 (1995)
77. Hepatic
targeting of drugs and proteins by chemical modification.
Mitsuru
Hashida, Makiya Nishikawa, and Yoshinobu Takakura
Journal
of Controlled Release, 36(1-2), 99-107 (1995)
78. Physicochemical
and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes.
Ram
I. Mahato, Kenji Kawabata, Takehiko Nomura, Yoshinobu Takakura, and Mitsuru
Hashida
Journal
of Pharmaceutical Sciences, 84(11), 1267-1271 (1995)
79. Disposition
characteristics of recombinant human interleukin-11 after a bolus intravenous
administration in mice.
Akira
Takagi, Hideo Masuda, Yoshinobu Takakura, and Mitsuru Hashida
The
Journal of Pharmacology and Experimental Therapeutics, 275(2), 537-543 (1995)
Takuya
Fujita, Yoshinobu Takakura, Hitoshi Sezaki, and Mitsuru Hashida
Pharmaceutical
Sciences, 1(8), 371-375 (1995)
81. Renal
disposition characteristics of oligonucleotides modified at terminal linkages
in the perfused rat kidney.
Kenzo
Sawai, Takenori Miyao, Yoshinobu Takakura, and Mitsuru Hashida
Antisense
Research and Development, 5, 279-287 (1995)
82. Characterization
of LLC-PK1 kidney epithelial cells as an in vitro model for studying
renal tubular reabsorption of protein drugs.
Yoshinobu
Takakura, Takahiro Morita, Makoto Fujikawa, Mitsuko Hayashi, Hitoshi Sezaki,
Mitsuru Hashida, and Ronald T. Borchardt
Pharmaceutical
Research, 12(12), 1968-1972 (1995)
83. A
deconvolution method for estimating the first-pass metabolism of orally
administered drugs.
Fumiyoshi
Yamashita, Hiroto Bando, Yoshinobu Takakura, and Mitsuru Hashida
Biological
and Pharmaceutical Bulletin, 18(12), 1787-1789 (1995)
84. Theoretical
design of prodrug-enhancer combination based on a skin diffusion model:
Prediction of permeation of acyclovir prodrugs treated with
1-geranylazacycloheptan-2-one.
Hiroto
Bando, Toshihide Takagi, Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru
Hashida
Pharmaceutical
Research, 13(3), 427-432 (1996)
85. Disposition
characteristics of plasmid DNA in the single-pass rat liver perfusion system.
Mitsunobu
Yoshida, Ram I. Mahato, Kenji Kawabata, Yoshinobu Takakura, and Mitsuru Hashida
Pharmaceutical
Research, 13(4), 599-603 (1996)
86. Analysis of in vitro skin penetration of
acyclovir prodrugs based on a diffusion model with a metabolic process.
Hiroto
Bando, Mikiko Sahashi, Toshihide Takagi, Fumiyoshi Yamashita, Yoshinobu
Takakura, and Mitsuru Hashida
International
Journal of Pharmaceutics, 135(1,2), 91-102 (1996)
87. Development
and pharmacokinetics of galactosylated poly-L-glutamic acid as a biodegradable
carrier for liver-specific drug delivery.
Hideki
Hirabayashi, Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida
Pharmaceutical
Research, 13(6), 880-884 (1996)
88. Disposition
of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger
receptors in their renal uptake.
Kenzo
Sawai, Ram I. Mahato, Yoshikazu Oka, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Pharmacology and Experimental Therapeutics, 279(1), 284-290 (1996)
89. Pharmacokinetic
analysis of drug disposition after intratumoral injection in a tissue-isolated
tumor perfusion system.
Akira
Saikawa, Takehiko Nomura, Fumiyoshi Yamashita, Yoshinobu Takakura, Hitoshi
Sezaki, and Mitsuru Hashida
Pharmaceutical
Research, 13(10), 1438-1444 (1996)
90. Biliary
excretion of polystyrene microspheres with covalently linked FITC fluorescence
after oral and parenteral administration to male Wistar rats.
Praful
U. Jani, Takehiko Nomura, Fumiyoshi Yamashita, Yoshinobu Takakura, Alexander T.
Florence, and Mitsuru Hashida
Journal
of Drug Targeting, 4, 87-93 (1996)
91. Pharmacokinetics
and targeted delivery of proteins and genes.
Mitsuru
Hashida, Ram I. Mahato, Kenji Kawabata, Takenori Miyao, Makiya Nishikawa, and
Yoshinobu Takakura
Journal
of Controlled Release, 41, 91-97 (1996)
92. In
vivo skin penetration enhancement of acyclovir by theoretical design of
prodrug-enhancer combination.
Hiroto
Bando, Mikiko Sahashi, Saya Mohri, Fumiyoshi Yamashita, Yoshinobu Takakura, and
Mitsuru Hashida
International
Journal of Pharmaceutics, 145, 103-113 (1996)
93. Uptake
characteristics of oligonucleotides in the isolated rat liver perfusion system.
Yoshinobu
Takakura, Ram I. Mahato, Mitsunobu Yoshida, Taro Kanamaru, and Mitsuru Hashida
Antisense,
and Nucleic Acid Drug Development, 6, 177-183 (1996)
94. Physicochemical
and disposition characteristics of antisense oligonucleotides complexed with
glycosylated poly(L-lysine).
Ram I.
Mahato, Shigeo Takemura, Ken Akamatsu, Makiya Nishikawa, Yoshinobu Takakura,
and Mitsuru Hashida
Biochemical
Pharmacology, 53(6), 887-895 (1997)
95. In
vivo evaluation of acyclovir prodrug penetration and metabolism through rat
skin using a diffusion/bioconversion model.
Hiroto
Bando, Mikiko Sahashi, Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru
Hashida
Pharmaceutical
Research, 14(1), 56-62 (1997)
96. Renal
disposition of recombinant human interleukin-11 in the isolated perfused rat
kidney.
Akira
Takagi, Yoshiyuki Yabe, Yoshikazu Oka, Kenzo Sawai, Yoshinobu Takakura, and
Mitsuru Hashida
Pharmaceutical
Research, 14(1), 86-90 (1997)
97. A
physiological role of interferon (IFN)-b
derived from tumor: tumor growth of a mouse bladder carcinoma line MBT-2 is
partially suppressed by autocrine IFN-b.
Kenji
Kawabata, Sachiko Okamoto, Yoshinobu Takakura, Mitsuru Hashida, Takayuki
Hashimura, and Yoshihiko Watanabe
Cancer
Letters, 113, 159-164 (1997)
98. Non-polarized
secretion of mouse interferon-b
from gene-transferred human intestinal caco-2 cells.
Hashida
Pharmaceutical
Research, 14(4), 483-485 (1997)
99. Targeted
delivery of drugs and proteins to the liver via receptor-mediated endocytosis.
Mitsuru
Hashida, Hideki Hirabayashi, Makiya Nishikawa, and Yoshinobu Takakura
Journal
of Controlled Release, 46(1,2), 129-137 (1997)
100. Augmented
inhibitory effect of superoxide dismutase on superoxide anion release from
macrophages by direct cationization.
Toshihide
Takagi, Makiko Kitano, Sada Masuda, Hideaki Tokuda, Yoshinobu Takakura, and
Mitsuru Hashida
Biochimica
et Biophysica Acta, 1335(1-2), 91-98 (1997)
101. Pharmacokinetic
analysis of scavenger receptor-mediated uptake of anionized proteins in the
isolated perfused rat liver.
Hisao
Furitsu, Ken-ichi Ogawara, Takuya Fujita, Fumiyoshi Yamashita, Yoshinobu
Takakura, Hitoshi Sezaki, and Mitsuru Hashida
International
Journal of Pharmaceutics, 151, 15-26 (1997)
102. Uptake
characteristics of anionized and cationized proteins in brain microvessel
endothelial cells.
Hideaki
Tokuda, Hiroko Nagano, Yoshinobu Takakura, and Mitsuru Hashida
Pharmaceutical
Sciences, 3(3), 147-151 (1997)
103. Intratumoral
pharmacokinetics and in vivo gene expression of naked plasmid DNA and its
cationic liposome complexes after direct gene transfer.
Takehiko
Nomura, Shin Nakajima, Kenji Kawabata, Fumiyoshi Yamashita, Yoshinobu Takakura,
and Mitsuru Hashida
Cancer
Research, 57, 2681-2686 (1997)
104. Effects
of skin metabolism on percutaneous penetration of lipophilic drugs.
Hiroto
Bando, Saya Mohri, Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Pharmaceutical Sciences, 86(6), 759-761 (1997)
105. Synthesis
and biodistribution study of liver-specific prostaglandin E1
polymeric conjugate.
Ken
Akamatsu, Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida
International
Journal of Pharmaceutics, 155(1), 65-74 (1997)
106. 皮膚拡散モデルに基づく皮膚中薬物濃度勾配の評価
瀬古則貴，坂東博人，山下富義，高倉喜信，橋田 充
Drug
Delivery System, 12(5), 359-365 (1997)
107. Pharmacokinetic
analysis of hepatic uptake of galactosylated bovine serum albumin in a perfused
rat liver.
Ken-ichi
Ogawara, Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Controlled Release, 50(1/3), 309-317 (1998)
108. Cellular
uptake properties of oligonucleotides in LLC-PK1 renal epithelial
cells.
Yoshinobu
Takakura, Yoshikazu Oka, and Mitsuru Hashida
Antisense
and Nucleic Acid Drug Development, 8, 67-73 (1998)
109. Effect
of particle size and charge on the disposition of lipid carriers after
intratumoral injection into tissue-isolated tumors.
Takehiko
Nomura, Noriko Koreeda, Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru
Hashida
Pharmaceutical
Research, 15(1), 128-132 (1998)
110. Pharmacokinetic
characteristics and therapeutic effects of mitomycin C-dextran conjugates after
intratumoural injection.
Takehiko
Nomura, Akira Saikawa, Satoko Morita, Toshiyuki Sakaeda(ne Kakutani), Fumiyoshi
Yamashita, Kazuo Honda, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Controlled Release, 52(3), 239-252 (1998)
111. Uptake
and gene expression of naked plasmid DNA in cultured brain microvessel
endothelial cells.
Masaru
Nakamura, Pablo Davila-Zavala, Hideaki Tokuda, Yoshinobu Takakura, and Mitsuru
Hashida
Biochemical
and Biophysical Research Communications, 245, 235-239 (1998)
112. Involvement
of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages.
Toshihide
Takagi, Miwa Hashiguchi, Ram I. Mahato, Hideaki Tokuda, Yoshinobu Takakura, and
Mitsuru Hashida
Biochemical
and Biophysical Research Communications, 245, 729-733 (1998)
113. Control
of plasma cholesterol-lowering action of probucol with various lipid carrier
systems.
Toichi
Takino, Noriko Koreeda, Takehiko Nomura, Toshiyuki Sakaeda(ne Kakutani),
Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru Hashida
Biological
and Pharmaceutical Bulletin, 21(5), 492-497 (1998)
114. Targeted
delivery of plasmid DNA complexed with galactosylated poly(L-lysine).
Mitsuru
Hashida, Shigeo Takemura, Makiya Nishikawa, and Yoshinobu Takakura
Journal
of Controlled Release, 53(1/3), 301-310 (1998)
115. Biological
effects and cellular uptake of c-myc antisense oligonucleotides and their
cationic liposome complexes.
Taro
Kanamaru, Toshihide Takagi, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Drug Targeting, 5(4), 235-246 (1998)
116. Targeted
delivery of plasmid DNA to hepatocytes in vivo: optimization of the
pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by
controlling their physicochemical properties.
Makiya
Nishikawa, Shigeo Takemura, Yoshinobu Takakura, and Mitsuru Hashida
The Journal
of Pharmacology and Experimental Therapeutics, 287(1), 408-415 (1998)
117. Cationic liposome-mediated efficient induction of type I
interferons by a low dose of poly I: poly C in mouse cell lines.
Sachiko
Okamoto, Yoshihiko Watanabe, Yoshinobu Takakura, and Mitsuru Hashida
Journal
of Biochemistry, 124(4), 697-701 (1998)
118. Development of a macromolecular prodrug of FK 506: Ⅲ:
In vivo disposition of FK 506-dextran conjugate.
Mitsuru
Hashida
Transplantation
Proceedings, 30, 1029-1030 (1998)
119. Development of a macromolecular prodrug of FK 506: Ⅱ:
In vitro study for FK 506-dextran conjugate.
Hiroshi Yura, Norio Yoshimura,
Takashi Hamashima, Takahiro Oka, Yoshinobu Takakura, and Mitsuru Hashida
Transplantation
Proceedings, 30, 1031-1032 (1998)
120. Development of a macromolecular prodrug
of FK 506:Ⅰ.Synthesis
of FK 506-dextran conjugate.
Hiroshi Yura, Norio Yoshimura,
Takashi Hamashima, Takahiro Oka, Yoshinobu Takakura, and Mitsuru Hashida
Transplantation
Proceedings, 30, 3598-3599 (1998)
121. Asialoglycoprotein
receptor-mediated gene transfer using novel galactosylated cationic liposomes.
Shigeru Kawakami, Fumiyoshi Yamashita, Makiya Nishikawa, Yoshinobu
Takakura, and Mitsuru Hashida
Biochemical
and Biophysical Research Communications, 252(1), 78-83 (1998)
122. 薬物経皮吸収に及ぼす代謝の影響－代謝過程を考慮した皮膚拡散モデルに基づく解析－
Lim
Chee Wooi，山下富義，高倉喜信，橋田 充
Drug
Delivery System, 13(6), 423-428 (1998)
123. Hepatic
disposition characteristics of recombinant human interleukin-11(rhIL-11) in the
perfused rat liver.
Akira
Takagi, Yoshiyuki Yabe, Mitsunobu Yoshida, Yoshinobu Takakura, and Mitsuru
Hashida
Biological
and Pharmaceutical Bulletin, 21(12), 1364-1366 (1998)
124. Disposition characteristics of glycosylated
poly(amino acids) as liver cell-specific drug carrier.
Ken
Akamatsu, Makoto Imai, Yasuomi Yamasaki, Makiya Nishikawa, Yoshinobu Takakura,
and Mitsuru Hashida
Journal
of Drug Targeting, 6(3), 229-239 (1998)
125. Gene expression and antitumor effects following direct interferon
(IFN)-g
gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice.
Takehiko
Nomura, Kei Yasuda, Toshiko Yamada, Sachiko Okamoto, Ram. I. Mahato, Yoshihiko
Watanabe, Yoshinobu Takakura, and Mitsuru Hashida
Gene
Therapy, 6(1), 121-129 (1999)
126. Synthesis and pharmacokinetics of a novel macromolecular prodrug
of Tacrolimus (FK506), FK506-dextran conjugate.
Hiroshi
Yura, Norio Yoshimura, Takashi Hamashima, Ken Akamatsu, Makiya Nishikawa, Yoshinobu
Takakura, and Mitsuru Hashida
Journal
of Controlled Release, 57(1), 87-99 (1999)
127. Stimulation side-dependent asymmetrical secretion of poly I :poly
C-induced interferon-b
from polarized epithelial cell lines.
Sachiko
Okamoto, Kiyo Nakanishi, Yoshihiko Watanabe, Fumiyoshi Yamashita, Yoshinobu
Takakura, and Mitsuru Hashida
Biochemical
and Biophysical Research Communications, 254, 5-9 (1999)
128. Characterization of plasmid DNA binding and uptake by peritoneal
macrophages from class A scavenger receptor knockout mice.
Yoshinobu
Takakura, Toshihide Takagi, Miwa Hashiguchi, Makiya Nishikawa, Fumiyoshi
Yamashita, Takefumi Doi, Takeshi Imanishi, Hiroshi Suzuki, Tatsuhiko Kodama, and
Mitsuru Hashida
Pharmaceutical
Research, 16(4), 503-508 (1999)
129. Pharmacokinetic evaluation of biodistribution data obtained with
radiolabeled proteins in mice.
Makiya
Nishikawa, Frantisek Staud, Shigeo Takemura, Yoshinobu Takakura, and Mitsuru
Hashida
Biological
and Pharmaceutical Bulletin, 22(2), 214-218 (1999)
130. Pharmacokinetics and disposition characteristics of recombinant
decorin after intravenous injection into mice.
Hideo Masuda,
Yoshinobu Takakura, and Mitsuru Hashida
Biochimica
et Biophysica Acta, 1426, 420-428 (1999)
131. Hepatocyte-specific distribution of
catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in
mice.
Yoshiyuki Yabe, Yasuo Koyama, Makiya
Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida
Free Radical Research, 30, 265-274 (1999)
132. Pharmacokinetic
evaluation of mannosylated bovine serum albumin as a liver cell-specific
carrier: quantitative comparison with other hepatotropic ligands.
Ken-ichi Ogawara, Susumu Hasegawa, Makiya Nishikawa, Yoshinobu Takakura,
and Mitsuru Hashida
Journal
of Drug Targeting, 6(5), 349-360 (1999)
133. Liver uptake and hepato-biliary transfer
of galactosylated proteins in rats are determined by the extent of
galactosylation.
Frantisek
Staud, Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida
Biochimica
et Biophysica Acta, 1427(2), 183-192 (1999)
134. Hepatic uptake of polystyrene
microspheres in rats: effect of particle size on intrahepatic distribution.
Ken-ichi
Ogawara, Minoru Yoshida, Kazutaka Higaki, Toshikiro Kimura, Keiko Shiraishi,
Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida
Journal of Controlled Release, 59, 15-22 (1999)
135. Targeted delivery and improved
therapeutic potential of catalase by chemical modification: combination with
superoxide dismutase derivatives.
Yoshiyuki Yabe, Makiya Nishikawa,
Ayumi Tamada, Yoshinobu Takakura and Mitsuru Hashida
The Journal of Pharmacology and Experimental Therapeutics, 289(2),
1176-1184 (1999)
Frantisek Staud, Makiya Nishikawa,
Yoshinobu Takakura and Mitsuru Hashida
Journal of Pharmaceutical Sciences, 88(6), 577-585 (1999)
137. Development of a hepatocyte-specific
prostaglandin E1 polymeric prodrug and its potential for preventing
carbon tetrachloride-induced fulminant hepatitis in mice.
Ken
Akamatsu, Yasuomi Yamasaki, Makiya Nishikawa, Yoshinobu Takakura and Mitsuru
Hashida
The Journal of Pharmacology and
Experimental Therapeutics, 290(3), 1242-1249 (1999)
138. Mechanisms of hepatic disposition of
polystyrene microspheres in rats: Effects of serum depend on the sizes of
microspheres.
Ken-ichi Ogawara, Minoru
Yoshida, Jun-ichi Kubo, Makiya Nishikawa, Yoshinobu Takakura, Mitsuru Hashida,
Kazutaka Higaki and Toshikiro Kimura
Journal
of Controlled Release, 61(3), 241-250 (1999)
139. Design of polymeric prodrugs of
prostaglandin E1 having galactose residue for hepatocyte targeting.
Mitsuru
Hashida, Ken Akamatsu, Makiya Nishikawa, Fumiyoshi Yamashita and Yoshinobu
Takakura
Journal of Controlled 62(1-2), 253-262 (1999)
140. Interaction of polystyrene microspheres
with liver cells: Roles of membrane receptors and serum proteins.
Ken-ichi Ogawara, Minoru
Yoshida, Yoshinobu Takakura, Mitsuru Hashida, Kazutaka Higaki and Toshikiro
Kimura
Biochimica
et Biophysica Acta, 1472(1-2), 165-172 (1999)
141. Uptake by hepatocytes and biliary
excretion of intravenously administered polystyrene microspheres in rats
Ken-ichi Ogawara, Minoru
Yoshida, Kentaro Furumoto, Yoshinobu Takakura, Mitsuru Hashida,
Kazutaka Higaki and Toshikiro Kimura
Journal of Drug Targeting, 7(3),
213-221 (1999)
142. Hepatocyte-targeted in vivo gene
expression by intravenous injection of plasmid DNA complexed with synthetic
multi-functional gene delivery system.
Makiya Nishikawa, Masakatsu
Yamauchi, Kensuke Morimoto, Emi Ishida, Yoshinobu Takakura and Mitsuru Hashida
Gene Therapy, 7(7), 548-555 (2000)
143. Pharmacokinetics and in vivo gene
transfer of plasmid DNA complexed with mannosylated poly(L-Lysine) in mice.
Makiya Nishikawa, Shigeo
Takemura, Fumiyoshi Yamashita, Yoshinobu Takakura, Dirk K. F. Meijer, Mitsuru
Hashida and Pieter J. Swart
Journal of Drug Targeting, 8(1), 29-38
(2000)
144. Design of polymeric
prodrugs of PGE1 for cell-specific hepatic targeting.
Mitsuru Hashida, Ken
Akamatsu, Makiya Nishikawa, Fumiyoshi Yamashita, Hiroshi. Yoshikawa and
Yoshinobu Takakura
Die Pharmazie, 55(3), 202-205 (2000)
145. Intratumoral pharmacokinetics of
oligonucleotides in tissue-isolated tumor perfusion system.
Shin Nakajima, Yasuaki Koshino,
Takehiko Nomura, Fumiyoshi Yamashita, Sudhir Agrawal, Yoshinobu Takakura, and
Mitsuru Hashida
Antisense and Nucleic Acid Drug Development,
10, 105-110 (2000)
146. Effect of cationic liposomes on
intracellular trafficking and efficacy of antisense oligonucleotides in mouse
peritoneal macrophages.
Toshihide Takagi, Miwa
Hashiguchi, Tetsuhiko Hiramatsu, Fumiyoshi Yamashita, Yoshinobu Takakura and
Mitsuru Hashida
Journal of Drug Targeting, 7(5), 363-371
(2000)
147. Effect of
DNA/liposome mixing ratio on the physicochemical characteristics, cellular
uptake and intracellular and trafficking of plasmid DNA/cationic liposome
complexes and subsequent gene expression.
Fuminori Sakurai, Rui Inoue, Yasunobu
Nishino, Ayumi Okuda, Osamu Matsumoto, Tooru Taga, Fumiyoshi Yamashita,
Yoshinobu Takakura and Mitsuru Hashida
Journal of Controlled Release, 66,
255-269 (2000)
148. The
4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.
Takashi Kageyama, Masaru Nakamura, Yasuomi
Yamazaki, Yoshinobu Takakura, Mitsuru Hashida, Yoshikatsu Kanai, Mikihiko
Naito, Takashi Tsuruo, Nagahiro Minato, and Shun Shimohama
Brain Research, 879, 115-121, (2000)
149. Hepatic uptake and gene expression mechanisms following
intravenous administration of plasmid DNA by conventional and
hydrodynamics-based procedures
Naoki Kobayashi, Takeshi
Kuramoto, Kiyoshi Yamaoka, Mitsuru Hashida and Yoshinobu Takakura
Journal of Pharmacology and
Experimental Therapeutics, 297(3), 853-860 (2001)
150. In vivo recognition of mannosylated proteins by hepatic
mannose receptors and mannan-binding protein.
Praneet Opanasopit, Keiko Shiraishi, Makiya Nishikawa,
Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru Hashida
American
Journal of Physiology, 280, G879-G889 (2001)
151. Interaction between DNA-cationic liposome complexes and
erythrocytes is an important factor in systemic gene transfer via the
intravenous route in mice: The role of the neutral helper lipid.
Fuminori Sakurai, Tsuyoshi Nishioka, Hiroyuki
Saito, Teruhiko Baba, Ayumu Okuda, Osamu Matsumoto, Tooru Taga, Fumiyoshi
Yamashita, Yoshinobu Takakura, and Mitsuru Hashida
Gene Therapy, 8, 677-686 (2001)
152. Biliary excretion of polystyrene microspheres depends
on the type of receptor-mediated uptake in rat liver.
Kentaro Furumoto, Ken-ichi Ogawara, Minoru
Yoshida, Yoshinobu Takakura, Mitsuru Hashida, Kazutaka Higaki and Toshikiro
Kimura
Biochimica et
Biophysica Acta, 1526, 221-226 (2001)
153. Pharmacokinetic analysis of Lectin-dependent
biodistribution of fucosylated bovine serum albumin: A possible carrier for
Kupffer cells.
Praneet Opanasopit, Makiya Nishikawa, Fumiyoshi
Yamashita, Yoshinobu Takakura, and Mitsuru Hashida
Journal of Drug
Targeting, 9(5), 341-351 (2001)
154. The fate of poly(2-dimethyl amino
ethyl)methacrylate-based polyplexes after intravenous administration.
F. J. Verbaan, C. Oussoren, I. M. van Dam, Y.
Takakura, M. Hashida, D. J. A. Crommelin, W. E. Hennink and G. Storm
International Journal of Pharmaceutics, 214(1,2),
99-101 (2001)
155. Synthesis and pharmacological activity of a novel
water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E1
using lactosylated poly (L-glutamic hydrazide) as a carrier
Ken Akamatsu, Yasuomi Yamasaki,
Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida
Biochemical Pharmacology, 62(11) 1531-1536 (2001)
156. Effects of Erythrocytes and Serum Proteins on Lung
Accumulation of Lipoplexes Containing Cholesterol or DOPE as a Helper Lipid in
the Single-Pass Rat Lung Perfusion System
Fuminori Sakurai, Tsuyoshi
Nishioka, Fumiyoshi Yamashita, Yoshinobu Takakura and Mitsuru Hashida
European Journal of Pharmaceutics and
Biopharmaceutics, 52(2) 165-172 (2001)
157. Transport Characteristics of
Ebastine and Its Metabolites across Human Intestinal Epithelial Caco-2 Cell
Monolayers
Yuichiro
Imamura, Kazuteru Shimizu,
Fumiyoshi Yamashita, Kiyoshi Yamaoka, Yoshinobu
Takakura and Mitsuru Hashida
Biological and Pharmaceutical Bulletin, 24(8) 930-934 (2001)
158. Prevention of neutrophil-mediated hepatic ischemia/reperfusion
injury by SOD and catalase derivatives
Yoshiyuki Yabe, Naoki Kobayashi,
Tsuyoshi Nishihashi, Rei Takahashi, Makiya Nishikawa, Yoshinobu Takakura, and
Mitsuru Hashida
Journal of Pharmacology and
Experimental Therapeutics, 298(3), 894-899 (2001)
159. Surface
hydrophobicity of particles is not necessarily the most important determinant
in their
in vivo disposition after intravenous administration in rats.
Ken-ichi
Ogawara, Kentaro Furumoto, Yoshinobu Takakura, Mitsuru Hashida, Kazutaka Higaki
and Toshikiro Kimura
Journal of Controlled Release,
77(3), 191-198 (2001)
160. Electric charge on protein regulates its absorption from the rat
small intestine.
Makiya Nishikawa, Susumu Hasegawa, Fumiyoshi Yamashita,
Yoshinobu Takakura, and Mitsuru Hashida
American Journal of Physiology, 282, G711-G719 (2002)
161. Pharmacokinetic analysis of in vivo disposition of succinylated
proteins targeted to liver non-parenchymal cells via scavenger receptors:
Importance of molecular size and negative charge density for in vivo recognition
by receptors.
Yasuomi Yamasaki, Kazuya
Sumimoto, Makiya Nishikawa, Fumiyoshi Yamashita, Kiyoshi Yamaoka, Mitsuru Hashida
and Yoshinobu Takakura
Journal of Pharmacology and Experimental Therapeutics,
301(2), 467-477 (2002)
162. Effect of interferons on P-glycoprotein-mediated
rhodamine-123 efflux in cultured rat hepatocytes.
Yukiko Akazawa, Hiroko Kawaguchi,
Maki Funahashi, Yoshihiko Watanabe, Kiyoshi Yamaoka, Mitsuru Hashida and
Yoshinobu Takakura
Journal of Pharmaceutical Sciences,
91(10), 2110-2115 (2002)
163. Plasmid
DNA activate cultured murine macrophages to induce inflammatory cytokines in a
CpG motif-independent manner by complex formation with cationic liposomes.
Kei
Yasuda, Yoshiyuki Ogawa, Michiyuki Kishimoto, Toshihide Takagi, Mitsuru Hashida
and Yoshinobu Takakura
Biochemical and Biophysical
Research Communications, 293(1), 344-348 (2002)
164. Effect of co-administration of cationic macromolecules on the in
vivo disposition and in situ renal disposition characteristics of
rhIL-11.
Akira Takagi, Yoshiyuki Yabe,
Yoshikazu Oka, Yoshinobu Takakura and Mitsuru Hashida
Drug Metabolism and
Pharmacokinetics, 17(2), 136-141 (2002)
165. Secretion polarity of interferon (IFN)-b in epithelial cell lines.
Kiyo Nakanishi, Yoshihiko
Watanabe, Masato Maruyama, Fumiyoshi Yamashita, Yoshinobu Takakura and Mitsuru
Hashida
Archives of Biochemistry and
Biophysics, 402, 201-207 (2002)
166. The
role of tissue macrophages in the induction of proinflammatory cytokine
production following intravenous injection of lipoplexes.
Fuminori
Sakurai, Takeshi
Terada, Kei Yasuda,
Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru Hashida
Gene
Therapy, 9, 1120-1126 (2002)
167. Important role of serum proteins
associated on the surface of particles in their hepatic disposition.
Kentaro Furumoto, Ken-ichi Ogawara, Susumu Nagayama, Yoshinobu
Takakura, Mitsuru Hashida, Kazutaka Higaki and Toshikiro Kimura
Journal of Controlled Release, 83(1), 89-96 (2002)
168. Pharmacokinetics and preventive effects of targeted catalase
derivatives on hydrogen peroxide-induced injury in perfused rat liver.
Yoshiyuki
Yabe, Naoki Kobayashi, Makiya Nishikawa, Kiyoshi Mihara, Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru Hashida
Pharmaceutical Research, 19(12) 1815-1821 (2002)
169. Efficient
uptake and rapid degradation of plasmid DNA by murine dendritic cells via a
specific mechanism.
Takaharu
Yoshinaga, Kei Yasuda, Yoshiyuki Ogawa and Yoshinobu Takakura
Biochemical and Biophysical
Research Communications, 299(3), 389-394 (2002)
170. Therapeutic
effect of intravenous interferon gene delivery with naked plasmid DNA in murine
metastasis models
Naoki Kobayashi, Takeshi
Kuramoto, Shi Chen, Yoshihiko Watanabe and Yoshinobu Takakura
Molecular Therapy, 6(6), 737-744
(2002)
171. Efficient
Scavenger Receptor-mediated Hepatic Targeting of Proteins by Introduction of
Negative Charges on the Proteins by Aconitylation: the Influence of Charge
Density and Size of the Proteins Molecules.
Yasuomi Yamasaki, Jin Hisazumi,
Kiyoshi Yamaoka and Yoshinobu Takakura
European Journal of Pharmaceutical
Sciences, 18, 305-312 (2003)
172. Disposition
and Gene Expression Characteristics in Solid Tumors and Skeletal Muscle
Following Direct Injection of Naked Plasmid DNA in Mice.
Atsushi Kawase, Takehiko Nomura,
Kei Yasuda, Naoki Kobayashi, Mitsuru Hashida and Yoshinobu Takakura
Journal of Pharmaceutical Sciences,
92(6) 1295-1304 (2003)
173. Validation
of the chloramine-T induced oxidation of human serum albumin as a model for
oxidative damage in vivo.
Makoto Anraku, Ulrich Kragh-Hansen,
Keiichi Kawai, Toru Maruyama, Yasuomi Yamasaki, Yoshinobu Takakura and Masaki Otagiri
Pharmaceutical Research, 20(4) 684-692(2003)
174. Therapeutic
effect of intravenous delivery of lipoplexes containing the interferon-b
gene and poly I: poly C in a murine lung metastasis model.
Fuminori
Sakurai, Takeshi Terada, Masato Maruyama, Yoshihiko Watanabe, Fumiyoshi
Yamashita, Yoshinobu Takakura and Mitsuru Hashida
Cancer Gene Therapy, 10, 661-668 (2003)
175. Residualizing
Indium-111-Radiolabel for Plasmid DNA and Its Application to Tissue Distribution
Study.
Makiya
Nishikawa, Takayuki Nakano, Takayuki Okabe, Nobuko Hamaguchi, Yasuomi Yamasaki,
Yoshinobu Takakura, Fumiyoshi Yamashita, and Mitsuru Hashida
Bioconjugate Chemistry, 14(5), 955-961 (2003)
176. Effect of Interferon-g on the Pharmacokinetics of
Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse.
Hiroko Kawaguchi, Yumi Matsui,
Yoshihiko Watanabe, and Yoshinobu Takakura
Journal of Pharmacology and Experimental Therapeutics, 308(1) 91-96
(2004)
177. Vector-based In Vivo RNA Interference: Dose- and Time-Dependent
Suppression of Transgene Expression.
Naoki Kobayashi, Yumi Matsui,
Atsushi Kawase, Kazuhiro Hirata, Makoto Miyagishi, Kazunari Taira, Makiya
Nishikawa and Yoshinobu Takakura
Journal of Pharmacology and
Experimental Therapeutics, 308(2) 688-693 (2004)
178. An Evaluation Method
for Nonlinear Local Disposition in Rat Liver and Kidney
Takako Kato,
Kiyoshi Yamaoka and Yoshinobu Takakura
Drug Metabolism and Disposition,
32, 230-234 (2004)
179. Subcellular
Trafficking of Exogenously Expressed Interferon-gamma in Madin-Darby Canine
Kidney Cells
Masato Maruyama, Teruko Nishio,
Takako Kato, Toyokaza Yoshida, Chisaki Ishida, Yoshihiko Watanabe, Makiya
Nishikawa, Yasufumi Kaneda and Yoshinobu Takakura
Journal of Cellular Physiology, 201(1) 117-125 (2004)
180.
Hepatic Delivery of Particulates in the Submicron Range by a Hydrodynamic-based
Procedure: Implications for Particulate Gene Delivery Systems
Naoki Kobayashi, Kazuhiro Hirata,
Shi Chen, Atsushi Kawase, Makiya Nishikawa and Yoshinobu Takakura
Journal of Gene Medicine, 6(4) 455-463 (2004)
181.
Hydrodynamic-based Procedure Involves Transient Hyperpermeability in the
Hepatic Cellular Membrane: Implication of a Nonspecific Process in Efficient
Intracellular Gene Delivery
Naoki
Kobayashi, Makiya Nishikawa, Kazauhiro Hirata and Yoshinobu Takakura
Journal of Gene Medicine, 6(5) 584-592 (2004)
182. Induction of Cytotoxic T Lymphocytes
following Immunization with Cationized Soluble Antigen
Tomoko
Ikenaga, Yasuomi Yamasaki, Kohsuke Shakushiro, Makiya Nishikawa and Yoshinobu
Takakura
Vaccine, 22(20) 2609-2619 (2004)
183. Restricted Cytokine Production from Mouse
Peritoneal Macrophages in Culture in spite of Extensive Uptake of Plasmid DNA
Kei Yasuda, Hiroki
Kawano, Ikuko Yamane, Yoshiyuki Ogawa, Takaharu Yoshinaga, Makiya Nishikawa and
Yoshinobu. Takakura
Immunology, 111(3) 282-209 (2004)
184. Efficient Scavenger Receptor-mediated Uptake
and Cross-presentation of Negatively Charged Soluble Antigens by Dendritic
Cells
Kohsuke Shakushiro, Yasuomi
Yamasaki, Makiya Nishikawa and Yoshinobu
Takakura
Immunology, 112(2) 211-218 (2004)
185. Significant Role of Liver Sinusoidal
Endothelial Cells in Hepatic Uptake and Degradation of Naked Plasmid DNA
following Intravenous Injection
Jin Hisazumi, Naoki Kobayashi,
Makiya Nishikawa and Yoshinobu Takakura
Pharmaceutical Research, 21(7) 1223-1228 (2004)
186. Hepatic uptake of negatively
charged particles in rats: possible involvement of serum proteins in
recognition by scavenger receptor
K.Furumoto, S. Nagayama, K. Ogawara,
Y. Takakura, M. Hashida, K. Higaki and T. Kimura
Journal of Controlled Release, 97(1), 133-141 (2004)
187. Inhibition of experimental hepatic metastasis
by targeted delivery of catalase in mice
Makiya Nishikawa, Ayumi Tamada, Kenji
Hyoudou , Yukari Umeyama, Yuki Takahashi, Yuki Kobayashi, Hitomi Kumai, Emi Ishida,
Frantisek Staud, Yoshiyuki Yabe, Yoshinobu Takakura, Fumiyoshi Yamashita, Mitsuru
Hashida
Clinical and Experimental Metastasis, 21, 213-221 (2004)
188. Expression and visualization of a human
interferon-beta-enhanced green fluorescent protein chimeric molecule in
cultured cells.
Masaru Nakamura, Masato Maruyama,
Fumiyoshi Yamashita, Yoshinobu Takakura, Mitsuru Hashida, Yoshihiko Watanabe
Biological and Pharmaceutical Bulletin, 27(3),
411-414 (2004)
189. Exogenous expression of interferon-beta in
cultured brain microvessel endothelial cells
Masaru Nakamura, Shinsuke Yamaguchi,
Yoshihiko Watanabe, Fumiyoshi Yamashita, Yoshinobu Takakura, Mitsuru Hashida
Biological and Pharmaceutical Bulletin, 27(9),
1441-1443 (2004)
190. Secretion Mode and Subcellular Localization of
Human Interferon-b Exogenously Expressed in Porcine Renal Epithelial LLC-PK 1
Cells
Teruko Nishio, Masato Maruyama,
Toyokazu Yoshida, Yoshihiko Watanabe, Makiya Nishikawa and Yoshinobu Takakura
Biological and Pharmaceutical Bulletin, 27(10),
1653-1655 (2004)
191.
Simultaneous Detection of
DsRed2-tagged and EGFP-tagged Human b-Interferons in the Same Single Cells
Masato Maruyama, Teruko Nishio,
Toyokazu Yoshida, Chisaki Ishida, Kayo Ishida, Yoshihiko Watanabe, Makiya
Nishikawa and Yoshinobu Takakura
Journal of Cellular Biochemistry, 93, 497-502
(2004)
192. Macrophage activation by a DNA/cationic
liposome complex requires endosomal acidification and both TLR9-dependent and
-independent pathways
Kei Yasuda, Yoshiyuki
Ogawa, Ikuko Yamane and Yoshinobu Takakura
Journal of Leukocyte Biology, 77, 71-79 (2005)
193. Permeability modulation of human intestinal
Caco-2 cell monolayers by interferons
Hiroko Kawaguchi, Yukiko Akazawa,
Yoshihiko Watanabe, and Yoshinobu Takakura
European Journal of Pharmaceutics and Biopharmaceutics, 59, 45-50
(2005)
194. Pharmacokinetic and Tissue
Distribution Mechanism of Mouse Recombinant Heat Shock Protein 70 in Mice
Seiji Takemoto, Makiya Nishikawa and
Yoshinobu Takakura
Pharmaceutical Research, 22(3) 419-426 (2005)
195. Gene Silencing in Primary and Metastatic
Tumors by Small Interfering RNA Delivery in Mice: Quantitative Analysis Using
Melanoma Cells Expressing Firefly and Sea Pansy Luciferases
Yuki Takahashi, Makiya Nishikawa, Naoki Kobayashi and Yoshinobu
Takakura
Journal of Controlled Release, 105, 332-343 (2005)
196. Cholesterol is required for the
polarized secretion of erythropoietin in Madin-Darby canine kidney cells
Masato Maruyama,
Michiyuki Kishimoto, Kayo Ishida, Yoshihiko Watanabe, Makiya Nishikawa, Seiji
Masuda, Ryuzo Sasaki, Yoshinobu Takakura
Archives of Biochemistry and Biophysics, 438(2), 174-81 (2005)
197. The
Uptake and Degradation of DNA Is Impaired in Macrophages and Dendritic Cells
from NZB/W F1 Mice
Yoshiyuki Ogawa, Takaharu
Yoshinaga, Kei Yasuda, Makiya Nishikawa and Yoshinobu Takakura
Immunology Letters, 101, 32-40 (2005)
198. Manipulation of Local Disposition and Gene Expression
Characteristics of Plasmid DNA Following Intramuscular Administration by
Complexation with Cationic Macromolecule
Atsushi Kawase, Naoki Kobayashi, Keiko Isaji, Makiya Nishikawa, Yoshinobu
Takakura
International
Journal of Pharmaceutics, 293, 291-301(2005)
199. Sequence-specific Suppression of mdr1a/1b
Expression in Mice via RNA Interference
Yumi Matsui, Naoki Kobayashi,
Makiya Nishikawa and Yoshinobu Takakura
Pharmaceutical Research, 22(12):2091-2098 (2005)
200. Cellular uptake and activation characteristics of naked plasmid DNA
and its cationic liposome complex in human macrophages
Ikuko Yamane, Makiya Nishikawa and Yoshinobu Takakura
International
Journal of Pharmaceutics, 305, 145-153 (2005)
201. Inhibition
of metastatic tumor growth by targeted delivery of antioxidant enzymes
Makiya Nishikawa, Kenji Hyoudou, Yuki Kobayashi, Yukari Umeyama
Yoshinobu Takakura and Mitsuru Hashida
Journal of Controlled Release, 109(1-3), 101-107 (2005)
202. Moment
Analysis for Kinetics of Gene Silencing by RNA Interference
Yuki Takahashi, Kiyoshi Yamaoka,
Makiya Nishikawa, Yoshinobu Takakura
Biotechnology
and Bioengineering, 93(4), 816-819 (2006)
203. Histgram analysis of
pharmacokinetic parameters by bootstrap resampling from one-point data in
animal experiment
Seiji Takemoto, , Kiyoshi Yamaoka, Makiya Nishikawa, Yoshinobu Takakura
Drug Metabolism and Pharmacokinetics, 21(6), 458-64 (2006)
204. Enhanced Antigen-specific Antibody Production Following
Polyplex-based DNA Vaccination via the Intradermal Route in Mice
Atsushi Kawase, Keiko Isaji, Ayumi Yamaoka, Naoki Kobayashi, Makiya
Nishikawa, Yoshinobu Takakura
Vaccine, 24, 5535-5545 (2006)
205. Incorporation
into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of
recombinant human interleukin 11 (rhIL11)
Akira Takagi, Noboru Yamashita,
Tatsunobu Yoshioka, Yuuki Takaishi, Kiyo Nakanishi, Shigeo Takemura, Atsushi
Maeda, Katsumi Saito, Yoshinobu Takakura, Mitsuru
Hashida
Journal of Controlled Release, 115, 134-139 (2006)
206. Suppression of tumor growth by intratumoral
injection of short hairpin RNA-expressing plasmid DNA targeting b-catenin
or hypoxia inducible factor-1a
Yuki Takahashi, Makiya Nishikawa,
Yoshinobu Takakura
Journal of Controlled Release, 116, 90-95 (2006)
207. DNA and
its cationic lipid complexes induce CpG motif-dependent activation of murine
dendritic cells
Takaharu Yoshinaga, Kei Yasuda,
Yoshiyuki Ogawa, Makiya Nishikawa, Yoshinobu Takakura
Immunology, 120, 295-302 (2007)
208. Plasmid DNA uptake and subsequent cellular activation
characteristics in human monocyte-derived cells in primary culture
Yuga Fukuhara, Tomoyuki Naoi,
Yoshiyuki Ogawa,
Makiya Nishikawa, Yoshinobu Takakura
Journal of Pharmaceutical Sciences, 96(6), 1576-84 (2007)
209. Fetuin
mediates hepatic uptake of negatively charged nanoparticles via scavenger
receptor
Susumu Nagayama, Ken-ichi Ogawara, Keiko Minato, Yoshiko Fukuoka,
Yoshinobu Takakura, Mitsuru Hashida, Kazutaka Higaki ,Toshikiro
Kimura
International
Journal of Pharmaceutics, 329, 192-198 (2007)
210. Induction of antigen-specific cytotoxic T lymphocytes by
immunization with negatively-charged soluble antigen through scavenger
receptor-mediated delivery
Yasuomi Yamasaki, Tomoko Ikenaga,
Takayuki Ohthuki, Makiya Nishikawa, Yoshinobu Takakura
Vaccine, 25, 85-91 (2007)
211. Design of PCR-amplified DNA Fragments for
In Vivo Gene Delivery: Size-dependency on Stability and Transgene
Expression
Kazuhiro Hirata, Makiya Nishikawa, Naoki Kobayashi, Yuki Takahashi
and Yoshinobu Takakura
Journal of Pharmaceutical Sciences, 96, 2551-2561 (2007)
212. Improved
anti-cancer effect of interferon gene transfer by sustained expression using
CpG-reduced plasmid DNA
Hiroki Kawano, Makiya Nishikawa, Masaru Mitsui, Yuki Takahashi, Keiko
Hattori, Kiyoshi Yamaoka, Yoshihiko Watanabe and Yoshinobu Takakura
International Journal of Cancer, 121(2), 401-406 (2007)
213. Action Mechanism of Tachyplesin I and
Effects of PEGylation
Yuichi Imura, Minoru
Nishida, Yoshiyuki Ogawa, Yoshinobu Takakura, Katsumi Matsuzaki
Biochimica et Biophysica
Acta, 1768(5), 1160-1169 (2007)
214. Enhanced Pharmacological Activity of Recombinant Human
Interleukin-11 (rhIL11) by Chemical Modification with Polyethylene Glycol
Akira Takagi, Noboru Yamashita,
Tatsunobu Yoshioka, Yuuki Takaishi, Kyoko Sano, Hideto Yamaguchi, Atsushi
Maeda, Katsumi Saito, Yoshinobu Takakura, Mitsuru
Hashida
Journal of Controlled Release, 119(3), 271-278 (2007)
215. Effects of inflammatory response on in vivo transgene expression by
plasmid DNA in mice
Keiko Kako, Hiroyuki Yoshida, Makiya Nishikawa, and Yoshinobu
Takakura
Journal of Pharmaceutical Sciences, 97(8), 3074-3083 (2007)
216. Cellular activation by plasmid DNA in various macrophages in
primary culture
Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno
and Yoshinobu Takakura
Journal of Pharmaceutical Sciences, 97(10):4575-85 (2008)
217. Enhanced immunostimulatory activity of oligodeoxynucleotides by
Y-shape formation
Makiya Nishikawa,
Mitsuhiro Matono, Sakulrat Rattanakiat, Nao Matsuoka and Yoshinobu Takakura
Immunology, 124(2), 247-55 (2008)
218. Inhibition of tumor cell growth in the liver by RNA
interference-mediated suppression of HIF-1α expression in tumor cells and
hepatocytes
Yuki Takahashi, Makiya Nishikawa,
Yoshinobu Takakura
Gene Therapy, 15(8), 572-82 (2008)
219. Enhancement of
anti-proliferative activity of interferons by RNAi-mediated silencing of SOCS
gene expression in tumor cells
Yuki Takahashi, Haruka Kaneda, Nana Takasuka, Kayoko Hattori, Makiya Nishikawa, Yoshihiko
Watanabe, Yoshinobu Takakura
Cancer Science, 99(8):1650-5
(2008)
220. Unique Cytokine Production Profile following
Stimulation with DNA in Macrophages from NZB/W F1 Mice
Yoshiyuki Ogawa, Takaharu
Yoshinaga, Makiya
Nishikawa, Yoshinobu Takakura
Biological and Pharmaceutical Bulletin, 31(6), 1244-1249 (2008)
221. Gene silencing of b-catenin in melanoma cells retards their growth but promotes the
formation of pulmonary metastasis in mice
Yuki Takahashi, Makiya Nishikawa, Tetsuya Suehara, Naomi Takiguchi
and Yoshinobu Takakura
International Journal of Cancer, 123(10):2315-20 (2008)
222. Reactivation of Silenced Transgene Expression
in Mouse Liver by Rapid, Large-volume Injection of Isotonic Solution
Makiya Nishikawa, Ayumi Nakayama, Yuki Takahashi, Yasushi Fukuhara and
Yoshinobu Takakura
Human Gene Therapy, 19(10), 1009-20 (2008)
223. Quantitative and
temporal analysis of gene silencing in tumor cells induced by small interfering
RNA or short hairpin RNA expressed from plasmid vectors
Yuki Takahashi, Kiyoshi
Yamaoka, Makiya
Nishikawa, Yoshinobu Takakura
Journal of Pharmaceutical Sciences, 98(1):74-80 (2009)
224. Enhanced generation of cytotoxic T lymphocytes by
increased cytosolic delivery of MHC class I epitope fused to mouse heat shock
protein 70 via polyhistidine conjugation
Seiji Takemoto,
Makiya Nishikawa, Takayuki Otsuki, Ayumi Yamaoka, Kazuki Maeda,
Atsushi Ota, Yoshinobu Takakura
Journal
of Controlled Release, 135(1), 11-18 (2009)
225. Enhanced CTL response by controlled intracellular
trafficking of antigen in dendritic cells following DNA vaccination
Keiko Isaji, Atsushi Kawase,
Mitsuhiro Matono, Guan Xin, Makiya Nishikawa and Yoshinobu Takakura
Journal of Controlled Release, 135(2),
227-233 (2009)
226. Effects
of Methyl-b-Cyclodextrin Treatment on Secretion Profile of Interferon-b and ZO-1 Architecture
in MDCK Cell Monolayers
Masato Maruyama, Kayo Ishida,
Yoshihiko Watanabe, Makiya Nishikawa, Yoshinobu Takakura
Biological and Pharmaceutical Bulletin,
32(5),
910-915 (2009)
227. Effect of the content of unmethylated CpG
dinucleotides in plasmid DNA on sustainability of transgene expression
Masaru Mitsui, Makiya Nishikawa,
Lei Zang, Mitsuru Ando, Kayoko Hattori, Yuki Takahashi, Yoshihiko Watanabe,
Yoshinobu Takakura
Journal of Gene Medicine, 11(5),
435-43 (2009)
228. TLR9-depdendent
systemic interferon-beta production by intravenous injection of plasmid
DNA/cationic liposome complex in mice
Hiroyuki Yoshida, Makiya
Nishikawa, Sachiyo Yasuda, Yumiko Mizuno, Hiroyasu Toyota, Tsuyoshi Kiyota, Rei
Takahashi,Yoshinobu Takakura
Journal of Gene Medicine, 11(8), 708-17 (2009)
229. The
assembly of a short linear natural cytosine-phosphate-guanine DNA into
dendritic structures and its effect on immunostimulatory activity
Sakulrat
Rattanakiat, Makiya Nishikawa, Dan Luo, Yoshinobu
Takakura
Biomaterials, 30(29), 5701-5706
(2009)
230. Control of hypoxia-induced tumor cell adhesion
by cytophilic human catalase
Tomoya Yata, Makiya Nishikawa,
Chika Nishizaki, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai, Yoshinobu
Takakura.
Free Radical Biology and Medicine,
47(12):1772-8 (2009)
231. Induction
of Tumor-Specific Immune Response by Gene Transfer of Hsp70-Cell Penetrating
Peptide Fusion Protein to Tumors in Mice
Makiya Nishikawa, Takayuki
Otsuki, Atsushi Ota, Xin Guan, Seiji Takemoto,Yuki Takahashi, Yoshinobu
Takakura
Molecular Therapy, 18(2), 421-428
(2010)
232. Bootstrap
Method-based Estimation of the Minimum Sample Number for Obtaining
Pharmacokinetic Parameters in Preclinical Experiments
Seiji Takemoto, Kiyoshi Yamaoka,
Makiya Nishikawa, Yoshitaka Yano and Yoshinobu Takakura
Journal of Pharmaceutical Sciences, 99(4), 2176-2184 (2010)
233. Simultaneous
delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid
DNA/doxorubicin complex in mice
Yumiko Mizuno, Tomoyuki Naoi,
Makiya Nishikawa, Sakulrat Rattanakiat, Nobuko Hamaguchi, Mitsuru Hashida,
Yoshinobu Takakura
Journal of Controlled Release, 141(2):252-9 (2010)
234. Development of a novel
Hsp70-based DNA vaccine as a multifunctional antigen delivery system
Ayumi Yamaoka, Xin Guan, Seiji Takemoto, Makiya Nishikawa,
Yoshinobu Takakura
Journal of Controlled Release, 142(3):411-5 (2010)
235. Injection
site-dependent induction of immune response by DNA vaccine: comparison of skin
and spleen as a target for vaccination
Xin Guan, Makiya
Nishikawa, Seiji Takemoto, Yuji Ohno, Tomoya Yata, Yoshinobu Takakura
Journal of Gene Medicine, 12: 301-309 (2010)
236. Sustained exogenous expression of therapeutic
levels of interferon g ameliorates
atopic dermatitis in NC/Nga mice via Th1 polarization
Kayoko Hattori, Makiya Nishikawa,
Kanitta Watcharanurak, Akihiko Ikoma, Kenji Kabashima, Hiroyasu Toyota, Yuki
Takahashi, Rei Takahashi, Yoshihiko Watanabe, Yoshinobu Takakura
Journal of Immunology, 184(5):2729-35
(2010)
237. Comparison
of the type of liposome involving cytokine production induced by non-CpG
lipoplex in macrophages
Sachiyo Yasuda, Hiroyuki Yoshida,
Makiya Nishikawa, Yoshinobu Takakura
Molecular Pharmaceutics, 7(2):533-42 (2010)
238. Enhanced
generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins
harboring both CD8+ T cell and CD4+ T cell epitopes
Seiji Takemoto, Makiya Nishikawa,
Xin Guan, Yuji Ohno, Tomoya Yata, Yoshinobu
Takakura
Molecular Pharmaceutics, 7 (5), 1715–1723
(2010)
239. Persistent interferon transgene expression by
RNA interference-mediated silencing of interferon receptors
Yuki Takahashi, Elin Vikman,
Makiya Nishikawa,
Mitsuru Ando, Yoshihiko Watanabe, Yoshinobu Takakura
Journal of Gene Medicine, 12(9):739-46 (2010)
240. Structural
and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester
and phosphorothioate oligodeoxynucleotides
Nao
Matsuoka, Makiya Nishikawa*, Kohta Mohri, Sakulrat Rattanakiat and
Yoshinobu Takakura
Journal of Controlled Release, 148(3):311-6 (2010)
241 . Biodegradable
CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory
signals in tumor-bearing mice
Makiya Nishikawa, Yumiko Mizuno,
Kohta Mohri, Nao Matsuoka, Sakulrat Rattanakiat, Yuki Takahashi, Hisakage
Funabashi, Dan Luo, Yoshinobu Takakura
Biomaterials, 32(2):488-94
(2011)
242. 5'-phosphate oligodeoxynucleotides enhance the phosphodiester-CpG
DNA-induced inflammatory response in macrophages
Hiroyuki Yoshida, Makiya
Nishikawa, Tsuyoshi Kiyota, Shota Uno, Hiroyasu Toyota, Rei Takahashi, Miwako
Narita Yoshinobu Takakura
European Journal of Immunology, 41(2):425-36 (2011)
243. Inhibition of nuclear delivery of
plasmid DNA and transcription by interferon g:
hurdles to be
overcome
for sustained gene therapy
Lei Zang, Makiya Nishikawa, Kazuya Machida, Mitsuru Ando, Yuki Takahashi,
Yoshihiko Watanabe, Yoshinobu Takakura
Gene Therapy, 18(9), 891-897 (2011)
244. Prolonged circulation half-life of interferon
γ activity by gene delivery of interferon γ-serum albumin fusion protein in
mice.
Noriko Miyakawa, Makiya Nishikawa, Yuki Takahashi,
Mitsuru Ando, Masayuki Misaka Yoshihiko Watanabe, Yoshinobu
Takakura
Journal of Pharmaceutical Sciences, 100(6), 2350-2357 (2011)
245. Positive Correlation Between the Generation of
Reactive Oxygen Species and Activation/Reactivation of Transgene Expression
After Hydrodynamic Injections into Mice.
Naomi Takiguch, Yuki Takahashi, Makiya Nishikawa, Yuriko
Matsui, Yasushi Fukuhara, Daihi Oushiki,
Kazuki Kiyose, Kenjiro Hanaoka,Tetsuo
Nagano, Yoshinobu Takakura
Pharmaceutical Research, 28(4):702-711 (2011)
246. Saturation of transgene protein synthesis from
mRNA in cells producing a large number of transgene mRNA.
Yuki Takahashi, Makiya Nishikawa,
Naomi Takiguchi, Tetsuya Suehara,Yoshinobu Takakura
Biotechnology and Bioengineering, 108(10):2380-2389 (2011)
247. Increase in CpG DNA-induced inflammatory
responses by DNA oxidation in macrophages and mice
Hiroyuki Yoshida, Makiya
Nishikawa, Tsuyoshi Kiyota, Hiroyasu Toyota, Yoshinobu Takakura
Free Radical Biology and Medicine,
51(2):424-31 (2011)
248. Inhibition
of surgical trauma-enhancedperitoneal dissemination of tumor cells by human
catalase derivatives in mice
Chika Nishizaki, Makiya
Nishikawa, Tomoya Yata, Toshiyuki Yamada, Yuki Takahashi, Masahide Oku, Hiroya
Yurimoto,Yasuyoshi Sakai, Kenji Nakanishi, Yoshinobu Takakura
Free Radical Biology and
Medicine, 51(3):773-9 (2011)
249. Comparison
of antigen expression from plasmid DNA in tumor-free and antigen-expressing
tumor-bearing mice
Xin Guan, Makiya Nishikawa, Hisoon Li, Rei Takahashi, Yuki
Takahashi, Yoshinobu Takakura
Human Vaccines and
Immunotherapeutics, 8(2):194-200 (2012)
250. Constant and steady transgene expression of interferon-g by
optimization of plasmid construct for safe and effective interferon-g gene
therapy
Mitsuru
Ando, Yuki
Takahashi, Makiya
Nishikawa, Yoshihiko
Watanabe, Yoshinobu
Takakura
Journal of Gene Medicine, 14(4):288-95
(2012)
Daihi Oushiki, Hirotatsu Kojima,
Yuki Takahashi, Toru Komatsu, Takuya Terai, Kenjiro Hanaoka, Makiya Nishikawa,
Yoshinobu Takakura, and Tetsuo Nagano
Analytical Chemistry, 84(10):4404-10
(2012)
252. Fibronectin inhibits cytokine production
induced by CpG DNA in macrophages without direct binding to DNA
Hiroyuki Yoshida, Makiya
Nishikawa, Sachiyo Yasuda, Hiroyasu Toyota, Tsuyoshi Kiyota, Yuki Takahashi,
Yoshinobu Takakura
Cytokine, 60(1):162-70 (2012)
253. Design and development of nano-sized DNA
assemblies in polypod-like structures as efficient vehicles for
immunostimulatory CpG motifs to immune cells
Kohta Mohri, Makiya Nishikawa,
Natsuki Takahashi, Tomoki Shiomi, Nao Matsuoka, Kohei Ogawa, Masayuki Endo,
Kumi Hidaka, Hiroshi Sugiyama,Yuki Takahashi, Yoshinobu Takakura
ACS Nano, 6(7):5931-40 (2012)
254. Self-assembling CpG DNA nanoparticles for
efficient antigen delivery and immunostimulation
Sakulrat
Rattanakiat,
Makiya Nishikawa, Yoshinobu Takakura
European Journal of Pharmaceutical
Sciences, 47(2):352-8 (2012)
255. Regulation of immunological balance by
sustained interferon-γ gene transfer for atopic dermatitis in mice
Kanitta Watcharanurak, Makiya
Nishikawa, Yuki Takahashi, Kenji Kabashima, Rei Takahashi, Yoshinobu Takakura
Gene Therapy, 20(5):538-44 (2013)
256. Increased immunostimulatory activity of
polypod-like structured DNA by ligation of the terminal loop structures
Kohta Mohri, Natsuki Takahashi, Makiya
Nishikawa, Eri Kusuki Tomoki Shiomi, Yuki Takahashi, Yoshinobu Takakura
Journal of Controlled Release, 163(3):285-292
(2012)
257. Poly(N-isopropylacrylamide)-Coated Microwell
Arrays for Construction and Recovery of Multicellular Spheroid
Kazunori Shimizu, Kosuke
Kusamori, Makiya Nishikawa, Narumi Mizuno, Tomoko Nishikawa, Akira Masuzawa,
Shingo Katano, Yuki Takahashi, Yoshinobu Takakura, Satoshi Konishi
Journal of Bioscience and
Bioengineering, 163(3):285-292 (2012)
258. Gene delivery of albumin binding
peptide-interferon g fusion protein with improved
pharmacokinetic properties and sustained biological activity
Noriko Miyakawa, Makiya Nishikawa, Yuki Takahashi,
Mitsuru Ando, Masayuki Misaka Yoshihiko Watanabe, Yoshinobu
Takakura
Journal of Pharmaceutical Sciences, 102(9):3110-8 (2013)
259. Visualization and in
vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection
Yuki Takahashi, Makiya Nishikawa, Haruka
Shinotsuka, Yuriko Matsui, Saori Ohara, Takafumi Imai, Yoshinobu Takakura
Journal of Biotechnology, 165(2):77-84 (2013)
260. Small molecule-induced clustering of heparan
sulfate promotes cell adhesion
Naohiro
Takemoto, Tetsuya
Suehara, Heidie L.
Frisco, Shin-ichi
Sato, Takuhito
Sezaki, Kosuke
Kusamori
, Yoshinori
Kawazoe, Sun Min
Park, Sayumi
Yamazoe, Yoshiyuki
Mizuhata, Rintaro
Inoue, Gavin J.
Miller, Steen U.
Hansen, Gordon C.
Jayson, John M.
Gardiner, Toshiji
Kanaya, Norihiro
Tokitoh, Kazumitsu
Ueda, Yoshinobu
Takakura, Noriyuki
Kioka, Makiya
Nishikawa, Motonari
Uesugi
Journal of the American Chemical
Society, 135(30):11032-9 (2013)
261. Expression profile-dependent improvement of
insulin sensitivity by gene delivery of interleukin 6 in type II diabetes model
mice
Hanae Mukumoto, Yuki Takahashi,
Mitsuru Ando, Makiya Nishikawa, Yoshinobu Takakura
Molecular Pharmaceutics, 10(10):3812-21 (2013)
262. Transplantation of insulin-secreting
multicellular spheroids for the treatment of type 1 diabetes in mice
Kosuke Kusamori, Makiya
Nishikawa, Narumi Mizuno, Tomoko Nishikawa, Akira Masuzawa, Kazunori Shimizu,
Satoshi Konishi, Yuki Takahashi, Yoshinobu Takakura
Journal of Controlled Release, 173,
119–124 (2014)
263. Long-term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice following Interferon-γ Gene
Transfer
Yuki Takahashi, Mitsuru Ando,
Makiya Nishikawa, Nobuhiko Hiraga,
Michio Imamura, Kazuaki Chayama, and Yoshinobu Takakura
Human Gene Therapy Clinical
Development 25(1):28-39 (2014)
264. Efficient delivery of immunostimulatory DNA
to mouse and human immune cells through the construction of polypod-like structured
DNA
Shota Uno, Makiya Nishikawa,
Kohta Mohri, Yuka Umeki, Noriyuki Matsuzaki, Yuki Takahashi, Haruyuki Fujita,
Norimitsu Kadowaki, Yoshinobu Takakura
Nanomedicine-Nanotechnology
Biology and Medicine, 10(4):765-74 (2013)
265. Injectable, Self-Gelling, Biodegradable, and
Immunomodulatory DNA Hydrogel for Antigen Delivery
Makiya Nishikawa, Kohei Ogawa,
Yuka Umeki, Kohta Mohri, Yohji Kawasaki, Hiroshi Watanabe, Natsuki
Takahashi, Eri Kusuki, Rei Takahashi, Yuki Takahashi, Yoshinobu Takakura
Journal of Controlled Release, 180:25-32
(2014)
266. Enhancement
of anticancer effect of interferon-γ gene transfer against
interferon-γ-resistant tumor by depletion of tumor-associated macrophages
Tsuyoshi Kiyota, Yuki Takahashi,
Kanitta Watcharanurak, Makiya Nishikawa, Saori Ohara,
Mitsuru Ando, Yoshihiko Watanabe, Yoshinobu Takakura
Molecular Pharmaceutics, 11(5):1542-9 (2014)
267. Removal of transgene-expressing cells by a
specific immune response induced by sustained transgene expression
Yalei
Yin, Yuki Takahashi, Norifumi Ebisuura, Makiya Nishikawa, Yoshinobu Takakura
Journal of Gene Medicine, 16(3-4):97-106
(2014)
268. Prevention of adverse events of interferon g gene therapy by gene delivery of
interferon g -heparin
binding domain fusion protein in mice
Mitsuru Ando, Yuki Takahashi,
Takuma Yamashita, Mai Fujimoto, Makiya Nishikawa, Yoshihiko Watanabe, Yoshinobu
Takakura
Molecular Therapy - Methods & Clinical Development, 1:14023 (2014)
269. Effects of upregulated indoleamine 2,
3-dioxygenase 1 by interferon g gene transfer on interferon g-mediated antitumor activity
Kanitta Watcharanurak, Lei Zang,
Makiya Nishikawa, Kayo Yoshinaga, Yasuko Yamamoto, Yuki Takahashi, Mitsuru
Ando, Kuniaki Saito, Yoshihiko Watanabe, Yoshinobu Takakura
Gene Therapy, 21(9):794-801 (2014)
270. X-ray Scattering from Immunostimulatory
Tetrapod-Shaped DNAs in Aqueous Solution to Explore Their Biological
Activity–Conformation Relationship
Yusuke Sanada, Shunsuke Sakamoto,
Tomoki Shiomi, Tadashi Okobira, Efstratios Mylonas, Noboru Ohta, Naoto Yagi,
Makiya Nishikawa, Isamu Akiba, Yoshinobu Takakura, Kazuo Sakurai
Journal of Physical Chemistry B, 118(35):10373-9 (2014)
271. Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell
Transplantation
Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke
Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe,
Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, and
Motonari Uesugi
Angewandte Chemie International Edition, 53(42):11208-13 (2014)
272. Quantitative analysis of tissue distribution
of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein
and iodine-125-labeled biotin derivative after intravenous injection in mice
Masaki Morishita, Yuki Takahashi,
Makiya Nishikawa, Kohei Sano, Kana Kato, Takuma Yamashita, Takafumi
Imai, Hideo Saji, Yoshinobu Takakura
Journal of Pharmaceutical Sciences, 104(2):705-13 (2015)
273. Nasal
delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory
DNA for effective induction of immune responses in mice
Yumiko Mizuno, Yuka Umeki, Yuki
Takahashi, Tetsuji Takabayashi, Shigeharu Fujieda, Yoshinobu Takakura, Makiya Nishikawa
Journal of Controlled Release, 200:52-9 (2015)
274. Macrophage-dependent clearance of systemically
administered B16BL6-derived exosomes from the blood circulation in mice
Takafumi Imai, Yuki Takahashi,
Makiya Nishikawa, Kana Kato, Masaki Morishita, Takuma Yamashita, Akihiro
Matsumoto, Chonlada Charoenviriyakul, Yoshinobu Takakura
Journal of Extracellular Vesicles, 4: 26238 (2015)
275. Self-assembling DNA dendrimer for
effective delivery of immunostimulatory CpG DNA to immune cells
Kohta Mohri, Eri Kusuki, Shozo
Ohtsuki, Natsuki
Takahashi, Masayuki Endo, Kumi Hidaka, Hiroshi Sugiyama, Yuki
Takahashi, Yoshinobu Takakura, Makiya Nishikawa
Biomacromolecules, 16(4):1095-101 (2015)
276. Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells
Shozo Ohtsuki,
Noriyuki Matsuzaki, Kohta Mohri, Masayuki Endo, Tomoko Emura, Kumi Hidaka,
Hiroshi Sugiyama, Yuki Takahashi, Kenichi Ishiyama, Norimitsu
Kadowaki, Yoshinobu Takakura, Makiya Nishikawa
Nucleic Acid Therapeutics, 25(5):245-53 (2015)
277. Induction
of Potent Antitumor Immunity by Sustained Release of Cationic Antigen from a
DNA-based Hydrogel with Adjuvant Activity
Yuka
Umeki, Kohta Mohri, Yohji Kawasaki, Hiroshi Watanabe, Rei Takahashi, Yuki,
Takahashi, Yoshinobu Takakura, and Makiya Nishikawa
Advanced Functional Materials, 25: 5758-5767 (2015)
278. Contribution of Epigenetic Modifications to
the Decline in Transgene Expression from Plasmid DNA in Mouse Liver
Lei Zang, Makiya
Nishikawa, Mitsuru Ando, Yuki Takahashi, Yoshinobu Takakura
Pharmaceutics, 7(3):199-212 (2015)
279. Atomic Force Microscopy Analysis of
Orientation and Bending of Oligodeoxynucleotides in Polypod-like Structured DNA
Tomoki
Shiomi, Mengmeng Tan, Natsuki Takahashi, Masayuki Endo, Tomoko Emura, Kumi
Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
Nano Research, 8(12): 3764-3771 (2015)
280. Efficient
amplification of self-gelling polypod-like structured DNA by rolling circle
amplification and enzymatic digestion
Tomoya Yata, Yuki Takahashi, Kumi
Hidaka, Masayuki Endo, Hiroshi Sugiyama, Mengmeng Tan, Yoshinobu Takakura,
Makiya Nishikawa
Scientific Reports, 5:14979
(2015)
281. Increased
insulin secretion from insulin-secreting cells by construction of mixed multicellular
spheroids
Kosuke Kusamori, Makiya Nishikawa,
Narumi Mizuno, Tomoko Nishikawa, Akira Masuzawa, Yutaro Tanaka, Yuya Mizukami,
Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi, Yoshinobu Takakura
Pharmaceutical Research, 33(1):247-56 (2016)
282 Self-assembling
DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells
Yu
Nishida, Shozo Ohtsuki, Yuki Araie, Yuka Umeki, Masayuki Endo, Tomoko Emura, ,
Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Yoshinobu Takakura, Makiya
Nishikawa
Nanomedicine-Nanotechnology
Biology and Medicine, 12(1):123-30 (2016)
283. Effect of exosome isolation methods on
physicochemical properties of exosomes and clearance of exosomes from the blood
circulation.
Takuma Yamashita, Yuki Takahashi,
Makiya Nishikawa, Yoshinobu Takakura
European Journal of Pharmaceutics
and Biopharmaceutics, 98: 1-8 (2016)
284. Application of Magnesium PyrophosphateeBased
Sponge-Like Microparticles to Enhance the Delivery Efficiency and Adjuvant Effects of
Polyriboinosinic-Polyribocytidylic Acid in Immune Cells
Shoichi Takagi, Yuki Takahashi,
Kanako Sugimura, Makiya Nishikawa, Yoshinobu Takakura
Journal of Pharmaceutical Sciences, 105(1):766-772 (2016)
285. Effects of transgene expression level per
cell in mice livers on induction of
transgene-specific immune responses after hydrodynamic gene transfer
Yalei
Yin, Yuki Takahashi, Atsushi Hamana, Makiya Nishikawa, Yoshinobu Takakura
Gene Therapy, 23(7):565-71 (2016)
286. Polypod-shaped DNAs:
Small Angle X-ray Scattering and Immunostimulatory Activity
Yusuke Sanada, Tomoki Shiomi, Tadashi Okobira, Mengmeng Tan, Makiya
Nishikawa, Isamu Akiba, Yoshinobu Takakura, Kazuo Sakurai
Langmuir, 32(15):3760-5 (2016)
287. Depressive symptoms as a side effect of
Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase1
Yuki Murakami, Takaaki Ishibashi,
Eiichi Tomita, Yukio Imamura, Tomoyuki Tashiro, Kanitta Watcharanurak, Makiya
Nishikawa, Yuki Takahashi, Yoshinobu Takakura, Satoko Mitani, Hidetsugu
Fujigaki, Yoshiji Ohta, Hisako Kubo, Takayoshi Mamiya, Toshitaka Nabeshima,
Hyoung-Chun Kim, Yasuko Yamamoto, Kuniaki Saito
Scientific Reports, in press
(2016)
288. Role of phosphatidylserine-derived negative
surface charges in the recognition and uptake of intravenously injected
B16BL6-derived exosomes by macrophages
Akihiro Matsumoto; Yuki Takahashi;
Makiya Nishikawa; Kohei Sano; Masaki Morishita; Chonlada Charoenviriyakul;
Hideo Saji; Yoshinobu Takakura
Journal of Pharmaceutical Sciences, in press (2016)
289. Interferon-inducible Mx
promoter-driven, long-term transgene expression system of interferon-β for cancer gene therapy
Atsushi
Hamana, Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura
Human Gene Therapy, in press (2016)
290. Exosome-based tumor antigens-adjuvant co-delivery utilizing
genetically engineered tumor cell-derived exosomes with immunostimulatory CpG
DNA
Masaki Morishita, Yuki Takahashi,
Akihiro Matsumoto, Makiya Nishikawa, Yoshinobu Takakura
Biomaterials, in
press (2016)
291. Cell type-specific and common characteristics of exosomes derived from mouse cell lines: yield, physicochemical properties, and pharmacokinetics
Chonlada Charoenviriyakul, Yuki Takahashi, Masaki Morishita, Akihiro Matsumoto, Makiya Nishikawa, Yoshinobu Takakura
European Journal of Pharmaceutical Sciences, 96, 316-322 (2017)
292. Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan
Yumiko Ishii-Mizuno, Yuka Umeki, Yoshinori Onuki, Hiroshi Watanabe, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
International Journal of Pharmaceutics, 516, 392-400 (2017)
293. Targeted delivery of interferon gamma using a recombinant fusion protein
of a fibrin-clot binding peptide with interferon gamma for cancer gene
therapy
Mitsuru Ando, Mai Fujimoto, Yuki Takahashi, Makiya Nishikawa, Atsushi Hamana,
Yoshinobu Takakura
Journal of Pharmaceutical Sciences, 106(3), 892-897 (2017)
294. Optimization of albumin secretion and metabolic activity of cytochrome
P450 1A1 of human hepatoblastoma HepG2 cells in multicellular spheroids
by controlling spheroid size
Tomoko Nishikawa, Yutaro Tanaka, Makiya Nishikawa, Yuka Ogino, Kosuke Kusamori,
Narumi Mizuno, Yuya Mizukami, Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi,
Yoshinobu Takakura
Biological and Pharmaceutical Bulletin, 40(3), 334-338 (2017)
295. In vitro and in vivo Toll-like receptor 9 stimulation activity of CpG oligodeoxynucleotide
incorporated into polypod-like DNA nanostructures
Yosuke Takahashi, Tatsuoki Maezawa, Yuki Araie, Yuki Takahashi, Yoshinobu
Takakura, Makiya Nishikawa
Journal of Pharmaceutical Sciences, 106(9), 2457-2462 (2017)
296. Size-controlled Multicellular spheroids of murine adenocarcinoma cells
efficiently establish pulmonary tumors in mice
Tomoko Nishikawa, Yutaro Tanaka, Makiya Nishikawa, Kosuke Kusamori, Narumi
Mizuno, Yuya Mizukami, Yuka Ogino, Kazunori Shimizu, Satoshi Konishi, Yuki
Takahashi, Yoshinobu Takakura
Biotechnology Journal, 12(8), 201600513 (2017)
297. Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-modified
DNA for Increased Antigen-specific Immune Response
Yuka Umeki, Masaaki Saito, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
Advanced Healthcare Materials, 6(20), 201700355 (2017)
298. Accelerated growth of B16BL6 tumor in mice through efficient uptake of
their own exosomes by B16BL6 cells
Akihiro Matsumoto, Yuki Takahashi, Makiya Nishikawa, Kohei Sano, Masaki
Morishita, Chonlada Charoenviriyakul, Hideo Saji, Yoshinobu Takakura
Cancer Sciences, 108(9), 1803-1810 (2017)
299. Amelioration of experimental autoimmune encephalomyelitis in mice by interferon-beta
gene therapy, using a long-term expression plasmid vector
Atsushi Hamana, Yuki Takahashi, Akane Tanioka, Makiya Nishikawa, Yoshinobu
Takakura
Molecular Pharmaceutics, 14(4), 1212-1217 (2017)
300. Elucidation of the mechanism of increased activity of immunostimulatory
DNA by formation of polypod-like structure
Kohta Mohri, Kengo Nagata, Shiori Toyama, Mao Nonomura, Yuki Takahashi,
Yoshinobu Takakura, Makiya Nishikawa, Shinji Sakuma
Pharmaceutical Research, 34(11), 2362-2370 (2017)
301. Evaluation of antiviral effect of type I, II, and III interferons on direct-acting
antiviral-resistant hepatitis C virus
Atsushi Hamana, Yuki Takahashi, Takuro Uchida, Makiya Nishikawa, Michio
Imamura, Kazuaki Chayama, Yoshinobu Takakura
Antiviral Research, 146, 130-138 (2017)
302. DNA Nanotechnology-based Composite-type Gold Nanoparticle-Immunostimulatory
DNA Hydrogel for Tumor Photothermal Immunotherapy
Tomoya Yata, Yuki Takahashi, Mengmeng Tan, Hirotaka Nakatsuji, Shozo Ohtsuki,
Tatsuya Murakami, Hiroshi Imahori, Yuka Umeki, Tomoki, Shiomi, Yoshinobu
Takakura, Makiya Nishikawa
Biomaterials, 146, 136-145 (2017)
303. Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9
cells by transfection of human macrophage scavenger receptor 1 gene
Shozo Ohtsuki, Yuki Takahashi, Takao Inoue, Yoshinobu Takakura, Makiya
Nishikawa
Scientific Reports, 7(1), 13661 (2017)
304. SELEX-Based Screening of Exosome-Tropic RNA
Takuma Yamashita, Haruka Shinotsuka, Yuki Takahashi, Kana Kato, Makiya
Nishikawa, Yoshinobu Takakura
Biological and Pharmaceutical Bulletin, 40(12), 2140-2145 (2017)
305. Enhanced class I tumor antigen presentation via cytosolic delivery of exosomal
cargos by tumor cell-derived exosomes displaying a pH-sensitive fusogenic
peptide
Masaki Morishita, Yuki Takahashi, Makiya Nishikawa, Reiichi Ariizumi, Yoshinobu
Takakura
Molecular Pharmaceutics, 536(1), 310-317 (2017)
306. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino
oligonucleotide for controlled tissue distribution in mice
Yosuke Takahashi, Yuki Araie, Daiki Nomura, Yuki Takahashi, Kohei Sano,
Hideo Saji, Yoshinobu Takakura, Makiya Nishikawa
Journal of Drug Targeting, 26(4), 373-381 (2018)
307. Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins
Atsushi Hamana, Yuki Takahashi, Akane Tanioka, Makiya Nishikawa, Yoshinobu
Takakura
International Journal of Pharmaceutics, 536(1), 310-317 (2018)
308. Control of polarization and tumoricidal activity of macrophages by multicellular
spheroid formation
Yutaro Tanaka, Makiya Nishikawa, Yuya Mizukami, Kosuke Kusamori, Yuka Ogino,
Shunsuke Nishimura, Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi,
Yoshinobu Takakura
Journal of Controlled Release, 270, 177-183 (2018)
309. Enhanced activity of immunosuppressive oligodeoxynucleotides by incorporating
them into hexapod-like nanostructured DNA
Yuki Araie, Yosuke Takahashi, Yuki Takahashi, Yoshinobu Takakura, Makiya
Nishikawa
Biological and Pharmaceutical Bulletin, 41(4), 564-569 (2018)
310. Role of extracellular vesicle surface proteins in the pharmacokinetics
of extracellular vesicles
Chonlada Charoenviriyakul, Yuki Takahashi, Masaki Morishita, Makiya Nishikawa,
Yoshinobu Takakura
Molecular Pharmaceutics, 15(3), 1073-1080 (2018)
311. Development of Orally-deliverable DNA Hydrogel by Microemulsification and
Chitosan Coating
Daiki Nomura, Masaaki Saito, Yosuke Takahashi, Yuki Takahashi, Yoshinobu
Takakura, Makiya Nishikawa
International Journal of Pharmaceutics, 547, 556-562 (2018)
312. Regulation of the distribution of cells in mixed spheroids by altering
migration direction
Yuya Mizukami, Yuki Takahashi, Kazunori Shimizu, Satoshi Konishi, Yoshinobu
Takakura, Makiya Nishikawa
Tissue Engineering Part A, 25(5-6):390-398 (2018)
313. Combined delivery of tumor antigen and immune cells by using self-assembling
immunostimulatory DNA hydrogel for antigen-specific tumor immunity
Yuka Umeki, Masaaki Saito, Kosuke Kusamori, Mari Tsujimura, Moeka Nishimura,
Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
Journal of Controlled Release, 288, 189-198 (2018)
314. Preservation of exosomes at room temperature using lyophilization
Chonlada Charoenviriyakul, Yuki Takahashi, Makiya Nishikawa, Yoshinobu
Takakura
International Journal of Pharmaceutics, 553(1-2), 1-7 (2018)
315. Multi-functionalization of Cells with a Self-assembling Molecule to Enhance
Cell Engraftment
Ippei Takashima, Kosuke Kusamori, Hayase Hakariya Megumi Takashima, Thi
Hue Vu, Yuya Mizukami, Naotaka Noda, Yukiya Takayama, Yousuke Katsuda,
Shin-ichi Sato, Yoshinobu Takakura, Makiya Nishikawa, Motonari Uesugi
ACS Chemical Biology, 14(4):775-783 (2019)
316. Effects of localization of antigen proteins in antigen-loaded exosomes
on efficiency of antigen presentation
Yuta Arima, Wen Liu, Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura
Molecular Pharmaceutics, 16(6):2309-2314 (2019)
317. Development of nanostructured RNA/DNA assembly as an adjuvant targeting
Toll-like receptor 7/8
Fusae Komura, Yuki Takahashi, Takao Inoue, Yoshinobu Takakura, Makiya Nishikawa
Nucleic Acid Therapeutics, 29(6):335-342 (2019)
318. Development of DNA-anchored assembly of small extracellular vesicle for
efficient antigen delivery to antigen presenting cells
Akihiro Matsumoto, Yuki Takahashi, Reiichi Ariizumi, Makiya Nishikawa,
Yoshinobu Takakura
Biomaterials, 225:119518 (2019)
319. Blood concentrations of small extracellular vesicles are determined by
a balance between abundant secretion and rapid clearance
Akihiro Matsumoto, Yuki Takahashi, Hsin-Yi Chang, Yi-Wen Wu, Aki Yamamoto,
Yasushi Ishihama, Yoshinobu Takakura
Journal of Extracellular Vesicle, 9(1):1696517 (2019)
320. Folding of Single-stranded Circular DNA into Rigid Rectangular DNA Accelerates
its Cellular Uptake
Shozo Ohtsuki, Yukako Shiba, Tatsuoki Maezawa, Kumi Hidaka, Masayuki Endo,
Hiroshi Sugiyama, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
Nanoscale, 11(48):23416-23422 (2019)
321. Analysis of tertiary structural features of branched DNA nanostructures
with partially common sequences using small-angle X-ray scattering
Mengmeng Tan, Natsuki Takahashi, Shota Fujii, Kazuo Sakurai, Yuki Takahashi,
Yoshinobu Takakura, Makiya Nishikawa
ACS Applied Bio Materials, in press (2019)
322. Development of RNA/DNA Hydrogel Targeting Toll-like Receptor 7/8 for Sustained
RNA Release and Potent Immune Activation
Fusae Komura, Kana Okuzumi, Yuki Takahashi, Yoshinobu Takakura, Makiya
Nishikawa
Molecules, 25(3) 728 (2020)
323. Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the
Combination of Mannose Modification and Incorporation into Nanostructured
DNA
Wenqing Liao, Sakiko Akahira, Rintaro, Iwata Hara, Takeshi Wada, Kosuke
Kusamori, Yoshinobu Takakura, Makiya Nishikawa
Biological and Pharmaceutical Bulletin, in press (2020)
324. Incorporation of gelatin microspheres into HepG2 human hepatocyte spheroids
for functional improvement through improved oxygen supply to spheroid core
Yuya Mizukami, Ai Moriya, Yuki Takahashi, Kazunori Shimizu, Satoshi Konishi,
Yoshinobu Takakura, Makiya Nishikawa
Biological and Pharmaceutical Bulletin, in press (2020)
325. Antitumor immunity by small extracellular vesicles collected from activated
dendritic cells through effective induction of cellular and humoral immune
responses
Akihiro Matsumoto, Maho Asuka, Yuki Takahashi, Yoshinobu Takakura
Biomaterials, 252:120112 (2020)
326. Construction of Monomeric and Dimeric G-quadruplex Structured CpG Oligodeoxynucleotides
for Enhanced Uptake and Activation in TLR9-positive Macrophages
Wenqing Liao, Mengmeng Tan, Kosuke Kusamori, Yoshinobu Takakura, Makiya
Nishikawa
Nucleic Acid Therapeutics, in press (2020)
327. Development of CD40L-modified tumor small extracellular vesicles for effective induction of antitumor immune response
Liu Wen, Masaki Morishita, Yuki Takahashi, Makiya Nishikawa, Yoshinobu
Takakura
Nanomedicine, in press (2020)
328. DNA Density-dependent Uptake of DNA Origami-based Two-or Three-dimensional
Nanostructures by Immune Cells
Tatsuoki Maezawa, Shozo Ohtsuki, Kumi Hidaka, Hiroshi Sugiyama, Masayuki
Endo, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
Nanoscale, in press (2020)
