研究室紹介

高倉喜信

たかくら よしのぶ

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E-mail: takakura@pharm.kyoto-u.ac.jp
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Last update : 19/December/2022

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    1.   Soluble macromolecular carriers for the delivery of antitumor drugs.

Hitoshi Sezaki, Yoshinobu Takakura, and Mitsuru Hashida

Advanced Drug Delivery Reviews, 3, 247-266 (1989)

    2.   Blood-brain barrier: Transport studies in isolated brain capillaries and in cultured brain endothelial cells.

Yoshinobu Takakura, K.L. Audus, and R.T. Borchardt

Advances in Pharmacology, 22, 137-165 (1991)

    3.   Macromolecular drug carrier systems in cancer chemotherapy :macromolecular prodrugs.

Yoshinobu Takakura, and Mitsuru Hashida

Critical Reviews in Oncology and Hematology, 18, 207-231 (1995)

    4.   Delivery of plasmid DNA to endothelial cells.

Yoshinobu Takakura, and Mitsuru Hashida

European Journal of Pharmaceutics and Biopharmaceutics, 42(4), 269-276 (1996)

    5.   Macromolecular carrier systems for targeted drug delivery: Pharmacokinetic considerations on biodistribition.

Yoshinobu Takakura, and Mitsuru Hashida

Pharmaceutical Research, 13(6), 820-831 (1996)

    6.   Control of pharmacokinetic profiles of drug-macromolecule conjugates.

Yoshinobu Takakura, Ram I. Mahato, Makiya Nishikawa, and Mitsuru Hashida

Advanced Drug Delivery Reviews, 19(3), 377-399 (1996)

    7.   Pharmacokinetic evaluation of polymeric carriers.

Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida

Advanced Drug Delivery Reviews, 21(2), 135-155 (1996)

    8.   Nonviral vectors for in vivo gene delivery: Physicochemical and pharmacokinetic considerations.

Ram I. Mahato, Yoshinobu Takakura, and Mitsuru Hashida

Critical Reviews in Therapeutic Drug Carrier Systems, 14(2), 133-172 (1997)

    9.   Development of targeted delivery systems for nucleic acid drugs.

Ram I. Mahato, Yoshinobu Takakura, and Mitsuru Hashida

Journal of Drug Targeting, 4(6), 337-357 (1997)

  10.   Delivery systems for gene drugs: The key to success of in vivo gene therapy.

Yoshinobu Takakura, and Mitsuru Hashida

Controlled Release Newsletter, 15(1), 5-7 (1998)

  11.   Extravasation of macromolecules.

Yoshinobu Takakura, Ram I. Mahato, and Mitsuru Hashida

Advanced Drug Delivery Reviews, 34(1), 93-108 (1998)

  12.   Development of gene drug delivery systems based on pharmacokinetic studies.

Yoshinobu Takakura, Makiya Nishikawa, Fumiyoshi Yamashita, and Mitsuru Hashida

European Journal of Pharmaceutical Sciences, 13, 71-76 (2001)

  13.   Cell-specific delivery of genes with glycosylated carriers.

Mitsuru Hashida, Makiya Nishikawa, Fumiyoshi Yamashita, and Yoshinobu Takakura

Advanced Drug Delivery Reviews, 52(3), 187-196 (2001)

  14.  Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery

Yoshinobu Takakura, Makiya Nishikawa, Fumiyoshi Yamashita and Mitsuru Hashida

Journal of Drug Targeting, 10(2), 99-104 (2002)

  15.  Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo

Kiyoshi Yamaoka and Yoshinobu Takakura

Drug Metabolism and Pharmacokinetics, 19(6), 397-406 (2004)

  16.  Pharmacokinetics in gene delivery

Yoshinobu Takakura and Mitsuru Hashida

Advanced Drug Delivery Reviews, 57(5), 667-668 (2005)

  17.  Theoretical considerations involving the pharmacokinetics of plasmid DNA

Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida

Advanced Drug Delivery Reviews, 57(5), 675-688 (2005)

  18.  The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels

Naoki Kobayashi, Makiya Nishikawa, Yoshinobu Takakura

Advanced Drug Delivery Reviews, 57(5), 713-731 (2005)

  19.  Pharmacokinetics of Plasmid DNA-Based Non-viral Gene Medicine

Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida

Advances in Genetics, 53, 47-68 (2005)

  20.  Role of immunostimulatory DNA and TLR9 in gene therapy

Kei Yasuda, Hermann Wagner and Yoshinobu Takakura

Critical Reviews in Therapeutic Drug Carrier Systems, 23, 89-109 (2006)

  21.  HSP-based tumor vaccines: state-of-the-art and future directions

Yoshinobu Takakura, Seiji Takemoto and Makiya Nishikawa

Current Opinion in Molecular Therapeutics, 9(4) 385-391 (2007)

  22.  Heat Shock Protein Derivatives for Delivery of Antigens to Antigen Presenting Cells

Makiya Nishikawa, Seiji Takemoto and Yoshinobu Takakura

International Journal of Pharmaceutics, 354(1-2), 23-7 (2007)

23.  Pharmacokinetic considerations regarding nonviral cancer gene therapy

Makiya Nishikawa, Yoshinobu Takakura, Mitsuru Hashida

Cancer Science, 99(5), 856-62 (2008)

24.       Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis

Makiya Nishikawa, Mitsuru Hashida, Yoshinobu Takakura

Advanced Drug Delivery Reviews, 61(4), 319-26 (2009)

25.   Towards Therapeutic Application of RNA-mediated Gene Regulation.

Yoshinobu Takakura

Advanced Drug Delivery Reviews, 61, 667 (2009)

26.   Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy

Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura

Advanced Drug Delivery Reviews, 61, 760-766 (2009)

27.   DNA-based nano-sized systems for pharmaceutical and biomedical applications

Makiya Nishikawa, Sakulrat Rattanakiat, Yoshinobu Takakura

Advanced Drug Delivery Reviews, 62(6):626-32 (2010)

28.   Development of safe and effective nonviral gene therapy by eliminating CpG motifs from plasmid DNA vector

Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura

Frontiers in Bioscience, 4:133-41 (2012)

29.   Nucleic Acid Drug Delivery and Targeting

Yoshinobu Takakura

Pharmaceutical Research, 28(4):691-693 (2011)

 30. Guest Editorial: Professor Mitsuru Hashida: His outstanding achievements in drug delivery research

Yoshinobu Takakura

Journal of Drug Targeting, 20(9):722-3 (2012)

 31. Controlling the kinetics of interferon transgene expression for improved gene therapy

Kanitta Watcharanurak, Makiya Nishikawa, Yuki Takahashi, Yoshinobu Takakura

Journal of Drug Targeting, 20(9):764-9 (2012)

32. DNA nanotechnology-based development of delivery systems for bioactive compounds

Kohta Mohri, Makiya Nishikawa, Yuki Takahashi, and Yoshinobu Takakura

European Journal of Pharmaceutical Sciences, 58:26-33 (2014)

33. A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Schowen KB, Schowen RL, Borchardt SE, Borchardt PM, Artursson P, Audus KL, Augustijns P, Nicolazzo JA, Raub TJ, Schöneich C, Siahaan TJ, Takakura Y, Thakker DR, Wolfe MS.

Journal of Pharmaceutical Sciences, 105(2), 370-385 (2015)

34. Pharmacokinetics of Exosomes - an Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics

Masaki Morishita, Yuki Takahashi, Makiya Nishikawa, and Yoshinobu Takakura

Journal of Pharmaceutical Sciences, 106(9):2265-2269 (2017)

35. Possibility of exosome-based therapeutics and challenges in production of exosomes eligible fo therapeutic application

Takuma Yamashita, Yuki Takahashi, Yoshinobu Takakura

Biological and Pharmaceutical Bulletin, 41(6):835-842 (2018)

36. Therapeutic application of small extracellular vesicles (sEVs): Pharmaceutical and pharmacokinetic challenges

Yoshinobu Takakura, Akihiro Matsumoto, Yuki Takahashi

Biological and Pharmaceutical Bulletin, 43(4):576-583 (2020)

 

 

 

和文

    1.   遺伝子医薬品のDDS開発とその問題点

高倉喜信,橋田 充

Drug Delivery System, 10(6), 391-398 (1995)

    2.   高分子薬物のデリバリーシステムの開発に関する研究

高倉喜信

薬学雑誌, 116(7), 519-532 (1996)

    3.   体内・細胞内動態制御機能を搭載した熱ショックタンパク質の開発とワクチンデリバリーへの応用

西川元也、竹本誠二、高倉喜信

薬学雑誌, 127(2), 293-300 (2007)

4.    がん細胞へのsiRNAリバリーとがん遺伝子治療への適用

高橋有己、西川元也、高倉喜信

薬学雑誌, 127(10), 1525-1531 (2007)

    5.   発現タンパク質の時空間制御による遺伝子治療効果の最適化

西川元也、高橋有己高倉喜信

薬学雑誌, 130(11), 1505-1511 (2010)

  6. . 機能性ペプチド融合によるIFNγ時空間制御

安藤 満、高橋有己、西川元也、高倉喜信

薬学雑誌, 132(12), 1399-1406 (2012)

  7. . DDSに資するエキソソームの開発

森下将輝、高橋有己、西川元也、高倉喜信

膜(Membrane, 40(5), 248-253 (2015)

  8. . DDS を指向したexosome 体内動態の解析と制御

高橋有己、西川元也、高倉喜信

薬学雑誌, 136(1):49-53 (2016)

  9. . 学術会議報告の概要

高倉喜信

薬学雑誌, 139(3); 395-400 (2019)

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