京都大学大学院薬学研究科薬品合成化学分野

Publications (previous ver.)

2019	Synthesis of Polycyclic Spirocarbocyles via Acid-Promoted Ring-Contraction/Dearomative Ring-Closure Cascade of Oxapropellanes Naoki Ogawa, Yousuke Yamaoka, Hiroshi Takikawa, Kiyosei Takasu Org. Lett. , in press.
	Synthesis of Dibenzoxazonines by Domino (2+2) Cycloaddition-4π Electrocyclic Ring Opening Reaction of Cyclic Imines with Ynamides Kiyosei Takasu, Masaki Tsutsumi, Tomohiro Ito, Hiroshi Takikawa, Yousuke Yamaoka Hetereocycles , in press.
	Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides and Echinocidins Kazuma Shimoda, Yousuke Yamaoka, Dongeun Yoo, Ken-ichi Yamada, Hiroshi Takikawa, and Kiyosei Takasu J. Org. Chem. 2019, 84, 11014-11024.
	Synthesis of Functionalized Medium-Sized trans-Cycloalkenes by 4π Electrocyclic Ring Opening?Alkylation Cascade Tomohiro Ito, Masaki Tsutsumi, Ken-ichi Yamada, Hiroshi Takikawa, Yousuke Yamaoka, Kiyosei Takasu Angew. Chem. Int. Ed. 2019, 58, 11836-11840.
	Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision Yuzo Mogi, Kazato Inanaga, Hidetoshi Tokuyama, Masataka Ihara, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu Org. Lett. 2019, 21, 3954-3958.
	Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine Masato Kono, Shingo Harada, Tomoyuki Nozaki, Yoshinori Hashimoto, Shun-ichi Murata, Harald Groger, Yusuke Kuroda, Ken-ichi Yamada, Kiyosei Takasu, Yasumasa Hamada, and Tetsuhiro Nemoto Org. Lett. 2019, 21, 3750-3754.
	Optical resolution via catalytic generation of chiral auxiliary Hiroki Kiyama, Tsubasa Inokuma, Yusuke Kuroda, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada Tetrahedron Lett. 2019, 60, 175-177.
2018	Silyl Enol Etherification by Tf₂NH/Amine Co-catalytic System for Minimizing Hazardous Waste Generation. Kei Kurahashi, Yousuke Yamaoka, Yoshiji Takemoto, and Kiyosei Takasu React. Chem. Eng. 2018, 3, 626-630.
	Synthesis and Properties of Tribenzocarbazoles via an Acid-promoted Retro (2+2)-Cycloaddition of Azapropellanes Naoki Ogawa, Yousuke Yamaoka, Hiroshi Takikawa, Kazunori Tsubaki, and Kiyosei Takasu J. Org. Chem. 2018, 83, 7994-8002.
	Total Synthesis of Phenanthroquinolizidine Alkaloid Cryptopleurine and Phenanthroindolizidine Alkaloid Tylophorine. Yousuke Yamaoka, Marie Taniguchi, Ken-ichi Yamada, and Kiyosei Takasu Heterocyles 2018, 97, 292-305.
	ポリケチド系多環性天然物の全合成における試行錯誤滝川紘有機合成化学協会誌 2018, 76, 478-481.
	Synthesis of Aza-Heterocycles and Related Molecules by Tf₂NH-Catalyzed Cycloadditions. Naoya Shindo, and Kiyosei Takasu, Heterocyles 2018, 96, 195-218.
	キラルリン酸による触媒的不斉置換反応およびアシル化反応への展開黒田悠介、原田慎吾、山田健一、高須清誠有機合成化学協会誌 2018, 76, 325-335.
2017	Synthesis of Multi-substituted Cyclobutenes: Cyclic Strategy for [2 + 2] Cycloaddition of Ketene Silyl Acetals with Propiolates. Yousuke Yamaoka, Motoki Ueda, Tohru Yamashita, Kazuma Shimoda, Ken-ichi Yamada and Kiyosei Takasu, Tetrahedron Lett. 2017, 58, 2944-2947.
	Synthesis of π-Extended Fluoranthenes via a KHMDS-promoted Anionic-Radical Reaction Cascade. Naoki Ogawa, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu, Org. Lett. 2017, 19, 3327-3330.
	Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists. Norihito Arichi, Shinichi Fujiwara, Michiyasu Ishizawa, Makoto Makishima, Duy H. Hua, Ken-ichi Yamada, Yousuke Yamaoka and Kiyosei Takasu, Bioorg. Med. Chem. Lett. 2017, in press.
	Site-selective Benzoin-type Cyclization of Unsymmetrical Dialdoses Catalyzed by N-Heterocyclic Carbenes for Divergent Cyclitol Synthesis. Bubwoon Kang, Yinli Wang, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu and Ken-ichi Yamada, Chem. Commun. 2017, 53, 4469-4472.
	Phosphine-Promoted Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide for the Synthesis of Oxa- and Azacycles. Yinli Wang, Raphael Oriez, Shogun Oh, Yasunori Miyakawa, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, Heterocycles 2017, 95, 314-321.
	人とのつながりが結実して誕生した新薬〜冬虫夏草を起源とする多発性硬化症治療薬フィンゴリモド〜藤多哲朗、高須清誠薬学研究（スタンダード薬学シリーズII-8）; 日本薬学会編; 東京化学同人, 2017
	薬を合成する——炭素の錬金術師高須清誠くすりをつくる研究者の仕事; 京都大学大学院薬学研究科編; 化学同人, 2017; 第２章.
2016	Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp³-Hybridized Carbon Atoms: Kinetic Resolution of beta-Amino Alcohols by p-Methoxybenzylation. Yusuke Kuroda, Shingo, Harada, Akinori Oonishi, Hiroki Kiyama, Yousuke Yamaoka, Ken-ichi Yamada and Kiyosei Takasu, Angew. Chem. Int. Ed. 2016, 55, 13137–13141.
	Desymmetrization of Acid Anhydride with Asymmetric Esterification Catalyzed by Chiral Phosphoric Acid. Ken-ichi Yamada, Akinori Oonishi, Yusuke Kuroda, Shingo Harada, Hiroki Kiyama, Yousuke Yamaoka, and Kiyosei Takasu, Tetrahedron Lett. 2016, 57 (36), 4098–4100.
	π-Delocalized Lipophilic Quaternary Cations as new Candidates for Antimalarial, Antitrypanosomal and Antileishmanial Agents: Synthesis, Evaluation of Antiprotozoal Potency and Insight of their Action Mechanism (Review). Kiyosei Takasu, Chem. Pharm. Bull., 2016, 137 64(7), 656–667.
	Synthesis of Multisubstituted Silyloxy-based Donor-Acceptor Cyclobutanes by an Acid-Catalyzed [2+2] Cycloaddition (Review). Kiyosei Takasu, Israel J. Chem., 2016, 137 56(6-7), 488–498.
	Striking Difference between Succinimidomethyl and Phthalimidomethyl Radicals in Conjugate Addition to Alkylidenemalonate Initiated by Dimethylzinc. Ken-ichi Yamada, Yusuke Matsumoto, Shintaro Fujii, Takehito Konishi, Yousuke Yamaoka, and Kiyosei Takasu, J. Org. Chem. 2016, 81 (9), 3809–3817.
	Oxa- and Azacycle-formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide with N-Heterocyclic Carbene. Yinli Wang, Raphaël Oriez, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, J. Org. Chem. 2016, 81 (6), 2652–2664.
	形式的[2+2]環化反応を用いた多環芳香族炭化水素の合成とその応用（H27日本薬学会近畿支部奨励賞受賞記念論文）山岡庸介薬学雑誌 2016, 136 (11), 1517–1523.
2015	An Arylative Ring Expansion Cascade of Fused Cyclobutenes via Short-Lived Intermediates with Planar Chirality. Norihito Arichi, Ken-ichi Yamada, Yousuke Yamaoka, and Kiyosei Takasu, J. Am. Chem. Soc. 2015, 137 (30), 9579–9582.
	Exploration of Dimethylzinc-Mediated Radical Reactions (Review). Ken-ichi Yamada and Kiyoshi Tomioka, Chem. Rec. 2015, 15 (5), 854–871.
	Asymmetric Total Synthesis of Tylophorine via a Formal [2+2] Cycloaddition Followed by Migrative Ring Opening of a Cyclobutane. Yousuke Yamaoka, Marie Taniguchi, Ken-ichi Yamada, and Kiyosei Takasu, Synthesis 2015, 47 (18), 2819–2825.
	Organocatalytic Activation of the Leaving Group in the Intramolecular Asymmetric S_N2′ Reaction. Yusuke Kuroda, Shingo Harada, Akinori Oonishi, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu, Angew. Chem. Int. Ed. 2015, 54 (28), 8263–8266. Synfacts 2015, 11 (8), 871.
	Cyclic Model for the Asymmetric Conjugate Addition of Organolithium with Enoate. Katsumi Nishimura, Naoshi Fukuyama, Mitsuaki Yamashita, Takaaki Sumiyoshi, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka, Synthesis 2015, 47 (15), 2256–2264.
	A Short Synthesis of (+)-β-Lycorane by Asymmetric Conjugate Addition Cascade. Katsumi Nishimura, Naoshi Fukuyama, Tomohisa Yasuhara, Mitsuaki Yamashita, Takaaki Sumiyoshi, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka, Tetrahedron 2015, 71 (39), 7222–7226.
	The Development of a Brønsted Acid-promoted Arene-Ynamide Cyclization toward the Total Syntheses of Marinoquinolines A and C, and Aplidiopsamine A. Yousuke Yamaoka, Takahiro Yoshida, Makiko Shinozaki, Ken-ichi Yamada, and Kiyosei Takasu, J. Org. Chem. 2015, 80 (2), 957–964. Synfacts 2015, 11 (4), 358.
	Hydrostannylation–Cross-Coupling Strategy for Stereoselective Synthesis of Alkylidenemalonates and Related α,β-Unsaturated Esters. Shinichi Fujiwara, Romain Cadou, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, Eur. J. Org. Chem. 2015, (6), 1264–1272.
	Synthesis of Steroidal Derivatives Bearing a Small Ring Using a Catalytic [2+2] Cycloaddition and a Ring-Contraction Rearrangement. Norihito Arichi, Kenji Hata, Yoshiji Takemoto, Ken-ichi Yamada, Yousuke Yamaoka, and Kiyosei Takasu, Tetrahedron 2015, 71 (2), 233–244.
	Contiguous Radical Pivaloyloxymethylation-Directed C(sp³)–H Iodination of N-Tosyl Cycloalkanecarbaldimine. Shintaro Fujii, Mayu Nakano, Yousuke Yamaoka, Kiyosei Takasu, Ken-ichi Yamada, and Kiyoshi Tomioka, Tetrahedron Lett. 2015, 56 (23), 3086–3089.
	N-Heterocyclic Carbene-Catalyzed Benzoin Strategy for Divergent Synthesis of Cyclitol Derivatives from Alditols. Bubwoong Kang, Toshiaki Sutou, Yinli Wang, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, Adv. Synth. Catal. 2015, 357 (1), 131–147.
2014	Radical Aminomethylation of Imines. Shintaro Fujii, Takehito Konishi, Yusuke Matsumoto, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, J. Org. Chem. 2014, 79 (17), 8128–8133.
	Equilibration of the [2+2] Cycloaddition of Silyl Enol Ethers Catalyzed by Ethylaluminium Dichloride: Diastereoselectivity Switch in the Synthesis of Fused Cyclobutanes. Kenji Hata, Norihito Arichi, Yousuke Yamaoka, Ken-ichi Yamada, Yoshiji Takemoto, and Kiyosei Takasu, Asian J. Org. Chem. 2014, 3 (6), 706–710.
	Synthesis of Functionalized Polycyclic Aromatic Compounds via a Formal [2 + 2]-Cycloaddition. Yuuki Nagamoto, Yousuke Yamaoka, Shun Fujimura, Yoshiji Takemoto, and Kiyosei Takasu, Org. Lett. 2014, 16 (3), 1008–1011.
	Copper-Catalyzed Asymmetric Addition Reaction of Imines. Kiyoshi Tomioka, Ken-ichi Yamada, and Yasutomo Yamamoto, Copper-Catalyzed Asymmetric Synthesis; Alexakis, A., Krause, N., Woodward, S., Eds; Wiley-VCH, 2014; Chapter 9.
2013	Enhanced Rate and Selectivity by Carboxylate Salt as a Basic Co-catalyst in Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Acylation of Secondary Alcohols. Satoru Kuwano, Shingo Harada, Bubwoong Kang, Raphaël Oriez, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, J. Am. Chem. Soc. 2013, 135 (31), 11485–11488.
	Chiral Phosphoric Acid-Catalyzed Kinetic Resolution of Secondary Alcohols. Shingo Harada, Satoru Kuwano, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu, Angew. Chem. Int. Ed. 2013, 52 (39), 10227–10230. Synfacts 2013, 9 (11), 1236.
	Selective Synthesis of Poly-Substituted Dihydroquinolines and α,β-Unsaturated Amidines by A Catalytic Reaction of Ynamides with Ketimines. Yusuke Kuroda, Naoya Shindoh, Yoshiji Takemoto, and Kiyosei Takasu, Synthesis 2013, 45 (16), 2328–2326.
	Synthesis of 2,3,4,5-Tetra-substituted Pyrroles via a Base-Promoted Double Michael Reaction of Oxime-enoates with Nitroolefins. Yusuke Kuroda, Kazuto Imaizumi, Ken-ichi Yamada, Yousuke Yamaoka, and Kiyosei Takasu, Tetrahedron Lett. 2013, 54 (31), 4073–4075.
	Critical Profiles of Chiral Diether-Mediated Asymmetric Conjugate Aminolithiation of Enoate with Lithium Amide as a Key to the Total Synthesis of (–)-Kopsinine. Shingo Harada, Takeo Sakai, Kiyosei Takasu, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka, Tetrahedron 2013, 69 (15), 3264–3273.
	pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols. Yuuki Nagamoto, Akira Hattori, Hideaki Kakeya, Yoshiji Takemoto, and Kiyosei Takasu, Chem. Commun. 2013, 49 (26), 2622–2624.
	Study of Ring-Opening Reaction of Spiro[5.2]octenes with Aqueous Hydro-halic Acid: Substituent Effect on the Regioselectivity. Yuuki Nagamoto, Yoshiji Takemoto, and Kiyosei Takasu, Synlett 2013, 24 (1), 120–124.
	Catalytic [2+2] Cycloaddition of Silyl Enol Ethers. Yousuke Yamaoka and Kiyosei Takasu, Methods and Applications of Cycloaddition Reactions in Organic Syntheses; Nishiwaki, N. Ed; Wiley-VCH, 2013; Chapter 4.
	Heterogeneous Reactions. Kiyosei Takasu, Microreactors in Organic Chemistry and Catalysis, 2nd edition; Wirth, T. Ed; Wiley-VCH, 2013; Chapter 7.
2012	Total Synthesis of (+)-trans-Dihydronarciclasine Utilizing Asymmetric Conjugate Addition. Ken-ichi Yamada, Yuzo Mogi, Magdi A. Mohamed, Kiyosei Takasu, and Kiyoshi Tomioka, Org. Lett. 2012, 14 (23), 5868–5871.
	General Entry to Asymmetric One-Pot [N + 2 + n] Cyclization for the Synthesis of Three- to Seven-Membered Azacycloalkanes. Shingo Harada, Takeo Sakai, Kiyosei Takasu, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka, J. Org. Chem. 2012, 77 (17), 7212–7222. Featured Article.
	Total Synthesis of (–)-Kopsinine by an Asymmetric One-Pot [N+2+3] Cyclization. Shingo Harada, Takeo Sakai, Kiyosei Takasu, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka, Chem. Asian. J. 2012, 7 (10), 2196–2198.
	Radical One-Pot α,β-Dual and β-Mono Oxymethylation of Alkylidenemalonate. Ken-ichi Yamada, Takehito Konishi, Mayu Nakano, Shintaro Fujii, Romain Cadou, Yasutomo Yamamoto, and Kiyoshi Tomioka, J. Org. Chem. 2012, 77 (13), 5775–5780.
	Steric Tuning of Chiral C₂-Symmetric NHC in Gold-Catalyzed Asymmetric Cyclization of 1,6-Enynes. Ken-ichi Yamada, Yasumasa Matsumoto, Khalid B. Selim, Yasutomo Yamamoto, and Kiyoshi Tomioka, Tetrahedron 2012, 68 (22), 4159–4165.
	High Performance of N-Alkoxycarbonyl-Imines in Triethylborane-Mediated Tin-Free Radical Addition. Ken-ichi Yamada, Takehito Konishi, Mayu Nakano, Shintaro Fujii, Romain Cadou, Yasutomo Yamamoto, and Kiyoshi Tomioka, J. Org. Chem. 2012, 77 (3), 1547–1553.
	Chemoselective Conversion of α-Unbranched Aldehyde to Amide, Ester, and Carboxylic Acid by NHC-Catalysis. Satoru Kuwano, Shingo Harada, Raphaël Oriez, and Ken-ichi Yamada, Chem. Commun. 2012, 48 (1), 145–147.
	Acid-Catalyzed [2 + 2] Cycloaddition at Room-Temperature with Suppression of Side Reactions by Using a Flow Microreactor System. Kei Kurahashi, Yoshiji Takemoto, and Kiyosei Takasu, ChemSusChem 2012, 5 (2), 270–273.
	Stoichiometric Auxiliary Ligands for Metals and Main Group Elements: Ligands for Lithium. Kiyoshi Tomioka, Yasutomo Yamamoto, and Ken-ichi Yamada, Comprehensive Chirality; Carreira, E. M., Yamamoto, H., Eds; Elsevier, 2012; Vol. 3, Chapter 20.
	C–C Bond Formation (Transition Metal-Catalyzed Michael). Kiyoshi Tomioka, Yasutomo Yamamoto, and Ken-ichi Yamada, Comprehensive Chirality; Carreira, E. M., Yamamoto, H., Eds; Elsevier, 2012; Vol. 4, Chapter 7.
2011	Formal (3 + 3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition–Claisen Condensation Accompanied with Isomerization of Silyl Enol Ethers. Takumi Azuma, Yoshiji Takemoto, and Kiyosei Takasu, Chem. Pharm. Bull. 2011, 59 (9),1190–1193.
	Steric Influence of N-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation. Xinyu Hao, Qian Chen, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka, Tetrahedron 2011, 67 (35), 6469–6473.
	Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines. Naoya Shindoh, Kazuo Kitaura, Yoshiji Takemoto, and Kiyosei Takasu, J. Am. Chem. Soc. 2011, 133 (22), 8470–8473.
	Chiral N-Heterocyclic Carbene–Copper(I)-Catalyzed Asymmetric Allylic Arylation of Aliphatic Allylic Bromides: Steric and Electronic Effects on γ-Selectivity. Khalid B. Selim, Hirotsugu Nakanishi, Yasumasa Matsumoto, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka, J. Org. Chem. 2011, 76 (5), 1398–1408.
	Rhodium-Catalyzed Asymmetric Phenylation of N-Phosphinoylarylimines with Triphenylborane. Xinyu Hao, Qian Chen, Masami Kuriyama, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka, Catal. Sci. Tech. 2011, 1 (1), 62–64.
	Unprecedented Synthesis of N,N-Divinylamines by Tf₂NH-Catalyzed Reaction of Ynamide with Ketimine. Naoya Shindoh, Yoshiji Takemoto, and Kiyosei Takasu, Heterocycles. 2011, 82 (2), 1133–1136.
	軸性不斉をもつアミジンの触媒的不斉合成法の開発とキラル合成素子としての活用. 高須清誠, 薬学研究の進歩 2011, 31–36.
2010	Stereoselective Formal Synthesis of (+)-Allokainic Acid via Thiol-Mediated Acyl Radical Cyclization. Ken-ichi Yamada, Tomohiro Sato, Masaki Hosoi, Yasutomo Yamamoto, and Kiyoshi Tomioka, Chem. Pharm. Bull. 2010, 58 (11), 1511–1516.
	Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N-Sulfinyl Imines. Tito Akindele, Ken-ichi Yamada, Takumi Sejima, Masaru Maekawa, Yasutomo Yamamoto, Mayu Nakano, and Kiyoshi Tomioka, Chem. Pharm. Bull. 2010, 58 (2), 265–269.
	Chiral Carbene Approach to Gold-Catalyzed Asymmetric Cyclization of 1,6-Enynes. Yasumasa Matsumoto, Khalid B. Selim, Hirotsugu Nakanishi, Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka, Tetrahedron Lett. 2010, 51 (2), 404–406.
2009	Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents Khalid B. Selim, Yasumasa Matsumoto, Ken-ichi Yamada, and Kiyoshi Tomioka, Angew. Chem. Int. Ed. 2009, 48 (46), 8733–8735. Hot Paper Synfacts 2010, (1), 77.
	Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines. Xinyu Hao, Masami Kuriyama, Qian Chen, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka, Org. Lett. 2009, 11 (19), 4470–4473. Synfacts 2010, (1), 69.
	Iron Chloride Enhancement of Dimethylzinc-Mediated Radical Conjugate Addition of Ethers and an Amine to Alkylidenemalonates Ken-ichi Yamada, Masaru Maekawa, Yasutomo Yamamoto, Mayu Nakano, Tito Akindele, and Kiyoshi Tomioka, Tetrahedron Lett. 2009, 50 (44), 6040–6043.
	Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids. Qian Chen, Masami Kuriyama, Xinyu Hao, Takahiro Soeta, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka, Chem. Pharm. Bull. 2009, 57 (9), 1024–1027.
	Asymmetric Construction of Binaphthyl by the Chiral Diether-Mediated Conjugate Addition of Naphthyllithium to Naphthalenecarboxylic Acid BHA Ester Mitsuru Shindo, Yasutomo Yamamoto, Ken-ichi Yamada, and Kiyoshi Tomioka, Chem. Pharm. Bull. 2009, 57 (7), 752–754.
	Accessing the Amide Functionality by the Mild and Low-Cost Oxidation of Imine. Magdi A. Mohamed, Ken-ichi Yamada, and Kiyoshi Tomioka, Tetrahedron Lett. 2009, 50 (26), 3436–3438.
	Total Synthesis of (–)-Lycorine and (–)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade. Ken-ichi Yamada, Mitsuaki Yamashita, Takaaki Sumiyoshi, Katsumi Nishimura, and Kiyoshi Tomioka, Org. Lett. 2009, 11 (7), 1631–1633. Synfacts 2009, (10), 1066.
	Dimethylzinc Initiated Radical Reactions (Review). Tito Akindele, Ken-ichi Yamada, and Kiyoshi Tomioka, Acc. Chem. Res. 2009, 42 (2), 345–355.
	Tandem Conjugate Addition–Aldol Cyclization of 2-Formylbenzylidenemalonate with Ether Radicals by the Mediation of Dimethylzinc. Ken-ichi Yamada, Masaru Maekawa, Tito Akindele, Yasutomo Yamamoto, Mayu Nakano, and Kiyoshi Tomioka, Tetrahedron 2009, 65 (4), 903–908.
2008	Chemoselective Conjugate Addition of Dimethylzinc-Mediated Ether and Acetal Radicals to Alkylidenemalonates and Asymmetric Reactions. Ken-ichi Yamada, Masaru Maekawa, Tito Akindele, Mayu Nakano, Yasutomo Yamamoto, and Kiyoshi Tomioka, J. Org. Chem. 2008, 73 (24), 9535–9538.
	Tin-free Radical Addition of Acyloxymethyl to Imines. Ken-ichi Yamada, Mayu Nakano, Masaru Maekawa, Tito Akindele, and Kiyoshi Tomioka, Org. Lett. 2008, 10 (17), 3805–3808. Synfacts 2008, (12), 1323.
	Copper-Catalyzed Asymmetric Allylic Substitution with Aryl and Ethyl Grignard Reagents. Khalid B. Selim, Ken-ichi Yamada, and Kiyoshi Tomioka, Chem. Commun. 2008, (41), 5140–5142.
	Copper-catalyzed Asymmetric Alkylation of Imines with Dialkylzinc and Related Reactions (Review). Ken-ichi Yamada and Kiyoshi Tomioka, Chem. Rev. 2008, 108 (8), 2874–2886.
	Conjugate Addition of THF-2-yl Radical with α,β-Unsaturated N-Tosyl Imines Using a Dimethylzinc–Air Initiator. Ken-ichi Yamada, Hiroyuki Umeki, Masaru Maekawa, Yasutomo Yamamoto, Tito Akindele, Mayu Nakano, and Kiyoshi Tomioka, Tetrahedron 2008, 64 (30-31), 7258–7265.
	C₂ Symmetric Chiral NHC Ligand for Asymmetric Quaternary Carbon Constructing Copper-Catalyzed Conjugate Addition of Grignard Reagents to 3-Substituted Cyclohexenones. Yasumasa Matsumoto, Ken-ichi Yamada, and Kiyoshi Tomioka, J. Org. Chem. 2008, 73 (12), 4578–4581.
	Base-Induced Sequential Cyclization-Rearrangement of Enantioenriched 3-Aminoalkanoates to Five- and Seven-Membered Lactam. Takeo Sakai, Ken-ichi Yamada, and Kiyoshi Tomioka, Chem. Asian J. 2008, 3 (8), 1486–1493.
	Amidophosphane–Copper(I)-Catalyzed Asymmetric Conjugate Addition of Dialkylzinc Reagents to Racemic 6-Substituted Cyclohexenones to Form 2,5-Di- and 2,2,5-Trisubstituted Cyclohexanones Khalid Selim, Takahiro Soeta, Ken-ichi Yamada, and Kiyoshi Tomioka, Chem. Asian J. 2008, 3 (2), 342–350.
2006	Asymmetric Radical Addition of Ethers to Enantiopure N–p-Toluenesulfinyl Aldimines Mediated by Dimethylzinc-Air. Tito Akindele, Yasutomo Yamamoto, Masaru Maekawa, Hiroyuki Umeki, Ken-ichi Yamada, and Kiyoshi Tomioka, Org. Lett. 2006, 8 (25), 5729–5732.
	Efficient Catalytic Asymmetric Synthesis of trans-2-substituted 5-Arylcyclohexanones by Rhodium-Catalyzed Conjugate Arylation of Racemic 6-Substituted Cyclohexenones. Qian Chen, Takahiro Soeta, Masami Kuriyama, Ken-ichi Yamada, and Kiyoshi Tomioka, Adv. Synth. Catal. 2006, 348 (18), 2604–2608.
	Tin-free Intermolecular Addition of Primary Alkyls to Imines via Dimethylzinc-Air Radical Process. Ken-ichi Yamada, Yasutomo Yamamoto, Masaru Maekawa, Tito Akindele, Hiroyuki Umeki and Kiyoshi Tomioka, Org. Lett. 2006, 8 (1), 87–89.
2005	Asymmetric Mannich-Type Addition of Lithium Glycolates to Imines Producing 3-Hydroxy-4-Phenylazetidin-2-Ones. (Prof. Kenji Koga’s Memorial issue) Hiroki Fujieda, Seiji Hata, Ken-ichi Yamada and Kiyoshi Tomioka, Heterocycles 2005, 66, 611–619.
	Asymmetric Synthesis of 5-Arylcyclohexenones by Rhodium(I)-Catalyzed Conjugate Arylation of Racemic 5-(Trimethylsilyl)cyclohexenone with Arylboronic Acids. Qian Chen, Masami Kuriyama, Takahiro Soeta, Xinyu Hao, Ken-ichi Yamada, and Kiyoshi Tomioka, Org. Lett. 2005, 7 (20), 4439–4441.
	Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1R,2R)-2-Dimethylamino-1,2-diphenylethanol. Mitsuaki Yamashita, Ken-ichi Yamada, and Kiyoshi Tomioka, Adv. Synth. Catal. 2005, 347 (11-13), 1649–1652.
	Chiral Amidophosphane–Copper Catalyzed Asymmetric Conjugate Addition of Dialkylzinc Reagents to Nitroalkenes. Fanny Valleix, Kazushige Nagai, Takahiro Soeta, Masami Kuriyama, Ken-ichi Yamada, and Kiyoshi Tomioka, Tetrahedron 2005, 61 (31), 7420–7424.
	Chiral Amino Alcohol-Mediated Asymmetric Conjugate Addition of Arylalkynes to Nitroolefins. Mitsuaki Yamashita, Ken-ichi Yamada, and Kiyoshi Tomioka, Org. Lett. 2005, 7i> (12), 2369–2371.
	Mechanistic Aspects of Thiyl Radical-Promoted Acyl Radical Cyclization of Formylenoate – Cyclization versus Oxidation. Kazuya Yoshikai, Tomoharu Hayama, Katsumi Nishimura, Ken-Ichi Yamada, and Kiyoshi Tomioka, Chem. Pharm. Bull. 2005, 53 (5), 586–588. Cover Figure
	Thiol-Catalyzed Acyl Radical Cyclization of Alkenals. Kazuya Yoshikai, Tomoharu Hayama, Katsumi Nishimura, Ken-ichi Yamada, and Kiyoshi Tomioka, J. Org. Chem. 2005, 70 (2), 681–683.
	Dimethylzinc-InitiatedRadical Reaction of Cyclic Ethers with Arylamines, Alkoxyamines, and Dialkylhydrazines. Yasutomo Yamamoto, Masaru Maekawa, Tito Akindele, Ken-ichi Yamada and Kiyoshi Tomioka, Tetrahedron 2005, 61 (2), 379–384.
2004	Structure Tuning of Lithium Amide for Asymmetric 1,4-Addition to Cinnamate and Subsequent Demasking. Takeo Sakai, Masahiro Doi, Yoshito Kawamoto, Ken-ichi Yamada, and Kiyoshi Tomioka, Tetrahedron Lett. 2004, 45 (50), 9261–9263.
	Radical Reactions Initiated by Diorganozinc (Review). Ken-ichi Yamada, Yasutomo Yamamoto and Kiyoshi Tomioka, J. Synth. Org. Chem. Jpn. 2004, 62 (11), 1158–1165.
	Direct Aminoalkylation of Cycloalkanes through Dimethylzinc-Initiated Radical Process. Ken-ichi Yamada, Yasutomo Yamamoto, Masaru Maekawa, Jingbo Chen, and Kiyoshi Tomioka, Tetrahedron Lett. 2004, 45 (35), 6595–6597. Cover Figure
	N-Allyl-N–tert-butyldimethylsilylamine for Chiral Ligand-Controlled Asymmetric Conjugate Addition to tert-Butyl Alkenoates. Hirohisa Doi, Takeo Sakai, Ken-ichi Yamada and Kiyoshi Tomioka, Chem. Commun. 2004, (16), 1850–1851.
	Catalytic Enhancement Effect of a Chiral Ligand on the Asymmetric Mannich-Type Reactions of Menthyl Alkanoates with Aldimines (Prof. Teruaki Mukaiyama issue). Seiji Hata, Tetsuo Iwasawa, Mayu Iguchi, Ken-ichi Yamada and Kiyoshi Tomioka, Synthesis 2004, (9), 1471–1475.
	Lithium Amide-Assisted Asymmetric Mannich-Type Reactions of Menthyl Acetate with PMP-Aldimines. Seiji Hata, Mayu Iguchi, Tetsuo Iwasawa, Ken-ichi Yamada and Kiyoshi Tomioka, Org. Lett. 2004, 6 (11), 1721–1723.
	Improved Asymmetric Synthesis of Dopamine D1 Full Agonist, Dihydrexidine, Employing Chiral Ligand-Controlled Asymmetric Conjugate Addition of Aryllithium to a Nitroalkene. Mitsuaki Yamashita, Ken-ichi Yamada, and Kiyoshi Tomioka, Tetrahedron 2004, 60 (19), 4237–4242.
	Efficient Synthesis of (±)-γ-Lycorane Employing Stereoselective Conjugate Addition to Nitroolefin. Tomohisa Yasuhara, Emi Osafune, Katsumi Nishimura, Mitsuaki Yamashita, Ken-ichi Yamada, Osamu Muraoka, and Kiyoshi Tomioka, Tetrahedron Lett. 2004, 45 (15), 3043–3045.
	Construction of Arene-Fused-Piperidine Motifs by Asymmetric Addition of 2-Trityl-oxymethylaryllithiums to Nitroalkenes: the Asymmetric Synthesis of a Dopamine D1 Full Agonist, A-86929. Mitsuaki Yamashita, Ken-ichi Yamada, and Kiyoshi Tomioka, J. Am. Chem. Soc. 2004, 126 (7), 1954–1955.
	Introduction of Functionalized C1, C2, and C3 Units to Imines through the Dimethylzinc-Air-Initiated Radical Addition. Ken-ichi Yamada, Yasutomo Yamamoto, Masaru Maekawa, and Kiyoshi Tomioka, J. Org. Chem. 2004, 69 (5), 1531–1534.
	Unexpected reaction of a dimethylzinc-generated THF radical with aldehydes. Yasutomo Yamamoto, Ken-ichi Yamada and Kiyoshi Tomioka, Tetrahedron Lett. 2004, 45 (4), 795–797.
	Addition of Organolithium Reagents to Double Bonds. Hiroshi Yamataka, Ken-ichi Yamada, and Kiyoshi Tomioka, The Chemistry of Organolithium Compounds; Rappoport, Z.; Marek, I., Eds; Wiley, 2004; Part 1, Chapter 14.
2003	Initiator-Dependent Chemoselective Addition of THF Radical to Aldehyde and Aldimine and Its Application to a Three-Component Reaction. Ken-ichi Yamada, Yasutomo Yamamoto, and Kiyoshi Tomioka, Org. Lett. 2003, 5 (10), 1797–1799.
	Total Synthesis of (±)-α- and β-Lycoranes by Sequential Chemoselective Conjugate Addition-Stereoselective Nitro-Michael Cyclization of an ω-Nitro-α,β,ψ,ω-unsaturated Ester. Tomohisa Yasuhara, Katsumi Nishimura, Mitsuaki Yamashita, Naoshi Fukuyama, Ken-ichi Yamada, Osamu Muraoka, and Kiyoshi Tomioka, Org. Lett. 2003, 5 (7), 1123–1126.
	Chiral Ligand-Controlled Asymmetric Conjugate Addition of Lithium Amides to Enoates. Hirohisa Doi, Takeo Sakai, Mayu Iguchi, Ken-ichi Yamada, and Kiyoshi Tomioka, J. Am. Chem. Soc. 2003, 125 (10), 2886–2887.
	Enantioselective Conjugate Addition and 1,2-Addition to C=N of Organolithium Reagents. Mayu Iguchi, Ken-ichi Yamada and Kiyoshi Tomioka, Organolithiums in Enantioselective Synthesis; D. M. Hodgson, Ed; Topics in Organometallic Chemistry 5; Springer, 2003; pp 37–59.
2002	Radical Addition of Ethers to Imines Initiated by Dimethylzinc. Ken-ichi Yamada, Hidetaka Fujihara, Yasutomo Yamamoto, Yoshihisa Miwa, Tooru Taga, and Kiyoshi Tomioka, Org. Lett. 2002, 4, 3509–3511.
	Hemilabile Amidomonophosphine Ligand–Rhodium(I) Complex-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Cycloalkenones. Masami Kuriyama, Kazushige Nagai, Ken-ichi Yamada, Yoshinao Miwa, Tooru Taga, and Kiyoshi Tomioka, J. Am. Chem. Soc. 2002, 124 (30), 8932–8939.
	Efficient Chiral Amidophosphine Ligand for Copper-catalyzed Asymmetric Addition of Diethylzinc to N-Sulfonylimines. Kazushige Nagai, Hidetaka Fujihara, Masami Kuriyama, Ken-ichi Yamada and Kiyoshi Tomioka, Chem. Lett. 2002, (1), 8–9.
2001	Electronic and Steric Control in Regioselective Addition Reactions of Organolithium Reagents with Enaldimines. Kiyoshi Tomioka, Yoshito Shioya, Yasuo Nagaoka, and Ken-ichi Yamada, J. Org. Chem. 2001, 66 (21), 7051–7054.
	The First Asymmetric Synthesis of a Dopamine D1 Agonist, Dihydrexidine, Employing Asymmetric Conjugate Addition Technology. Yasutomi Asano, Mitsuaki Yamashita, Kazushige Nagai, Masami Kuriyama, Ken-ichi Yamada, and Kiyoshi Tomioka, Tetrahedron Lett. 2001, 42 (48), 8493–8495.