[2013][2012][2011][2010][2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002][Review] [Miscellaneous]

2013

  1. Naniwa, Y.; Nakatsukasa, K.; Setsuda, S.; Oishi, S.; Fujii, N.; Matsuda, F.; Uenoyama, Y.; Tsukamura, H.; Maeda, K.I.; Ohkura, S.
    Effects of full-length kisspeptin administration on follicular development in Japanese black beef cows.
    J. Reprod. Dev. 59(6) 588-594. (2013) [PubMed]
  2. Suzuki, T.; Tokimizu, Y.; Katoono, R.; Fujiwara, K.; Naoe, S.; Fujii, N.; Ohno, H.
    5,10-Dihydrobenzo[a]indolo[2,3-c]carbazole: A highly fluorescent disk-shaped electron donor exhibiting dual UV-vis-NIR and fluorescence spectral changes upon electrolysis.
    Chem. Lett. 42(9) 1001-1003. (2013)
  3. Nakahara, T.; Uenoyama, Y.; Iwase, A.; Oishi S.; Nakamura, S.; Minabe, S.; Watanabe, Y.; Deura, C.; Noguchi, T.; Fujii, N.; Kikkawa, F.; Maeda,K.I.; Tsukamura, H.
    Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.
    J. Reprod. Dev.59(5) 479-484. (2013) 
  4. Mizuhara, T.; Kato, T.; Hirai, A.; Kurihara, H.; Shimada, Y.; Taniguchi, M.; Maeta, M.; Togami, H.; Shimura, K.; Matsuoka, M.; Okazaki, S.; Takeuchi, T.; Ohno, H.; Oishi, S.; Fujii, N.
    Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents.
    Bioorg. Med. Chem. Lett. 23(16) 4557-4561. (2013) 
  5. Yoshimitsu, Y.; Inuki, S.; Oishi, S.; Fujii, N.; Ohno, H.
    Palladium-catalyzed medium-ring formation for construction of the core structure of Laurencia oxacycles: synthetic study of laurendecumallene B.
    Org. Lett. 15(12) 3046-3049. (2013) 
  6. Yoshikawa, Y.; Oishi, S.; Kubo, T.; Tanahara, N.; Fujii, N.; Furuya, T.
    An optimized method of G-protein coupled receptor homology modeling: its application to the discovery of novel CXCR7 ligands.
    J. Med. Chem. 56(11) 4236-4251. (2013) 
  7. Noguchi, T.; Oishi, S.; Honda, K.; Kondoh, Y, Saito, T.; Kubo, T.; Kaneda, M.; Ohno, H.; Osada, H.; Fujii, N.
    Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.
    Bioorg. Med. Chem. Lett.23(13) 3802-3805. (2013) 
  8. Kobayashi, Y.; Oishi, S.; Kobayashi, K.; Ohno, H.; Tsutsumi, H.; Hata, Y.; Fujii, N.
    Synthesis and functional analysis of deferriferrichrysin derivatives: application to colorimetric pH indicators.
    Bioorg. Med. Chem. 21(14) 4296-4300. (2013) 
  9. Hattori, Y.; Nakamura, T.; Ohno, H.; Fujii, N.; Maitani, Y.
    Enhanced plasmid DNA transfer into tumor cells by nanoparticle composed of cholesteryl triamine and diamine.
    Biol. Pharm. Bull. 36(5) 856-860. (2013) 
  10. Chiba, H.; Sakai, Y.; Ohara, A.; Oishi, S.; Fujii, N.; Ohno, H.
    Convergent synthesis of (–)-quinocarcin based on the combination of Sonogashira coupling and gold(I)-catalyzed 6-endo-dig hydroamination.
    Chem. Eur. J. 19(27) 8875-8883. (2013) [PubMed]
  11. Hou, Z.; Oishi, S.; Suzuki, Y.; Kure, T.; Nakanishi, I.; Hirasawa, A.; Tsujimoto, G.; Ohno, H.; Fujii, N.
    Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.
    Org. Biomol. Chem. 11(20) 3288-3296. (2013) [PubMed]
  12. Yoshimitsu, Y.; Miyagaki, J.; Oishi, S.; Fujii, N.; Ohno, H.
    Synthesis of pachastrissamine (jaspine B) and its derivatives by the late-stage introduction of the C-2 alkyl side-chain using cross metathesis.
    Tetrahedron 69(21) 4211–4220. (2013)
  13. Izumi, K.; Kawaji, K.; Miyamoto, F.; Shimane, K.; Shimura, K.; Sakagami, Y.; Hattori, T.; Watanabe, K.; Oishi, S.; Fujii, N.; Matsuoka, M.; Kaku, M.; Sarafianos, S. G.; Kodama, E. N.
    Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design.
    Int. J. Biochem. Cell Biol. 45(4) 908–915. (2013) [PubMed]
  14. Misu, R.; Oishi, S.; Setsuda, S.; Noguchi, T.; Kaneda, M.; Ohno, H.; Evans B.; Navenot J. M.; Peiper S.C.; Fujii, N.
    Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes.
    Bioorg. Med. Chem. Lett. 23(9) 2628–2631. (2013) [PubMed]
  15. Misu, R.; Noguchi, T.; Ohno, H.; Oishi, S.; Fujii, N.
    Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists.
    Bioorg. Med. Chem. 21(8) 2413–2417. (2013) [PubMed]
  16. Mizuhara, T.; Oishi, S.; Ohno, H.; Shimura, K.; Matsuoka, M.; Fujii, N.
    Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182.
    Bioorg. Med. Chem. 21(7) 2079–2087. (2013) [PubMed]

2012

  1. Tanaka, G.; Nakase, I.; Fukuda, Y.; Masuda, R.; Oishi, S.; Shimura, K.; Kawaguchi, Y.; Takatani-Nakase, T.; Langel, U.; Gräslund, A.; Okawa, K.; Matsuoka, M.; Fujii, N.; Hatanaka, Y.; Futaki, S.
    CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV.
    Chem Biol.19, 1437-1446. (2012) [PubMed]
  2. Zhang Y, Patel S, Abdelouahab H, Wittner M, Willekens C, Shen S, Betems A, Joulin V, Opolon P, Bawa O, Pasquier F, Ito M, Fujii N, Gonin P, Solary E, Vainchenker W, Coppo P, De Botton S, Louache F.
    CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model.
    Cell Death Dis. 3 e396. (2012) [PubMed]
  3. Chiba H, Sakai Y, Oishi S, Fujii N, Ohno H.
    Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans and its application to the formal total synthesis of (-)-quinocarcinamide.
    Tetrahedron Lett. 53(46) 6273-6276. (2012)
  4. Mizuhara, T.; Oishi, S.; Ohno, H.; Shimura, K.; Matsuoka, M.; Fujii, N.
    Structure–activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents.
    Bioorg. Med. Chem. 20(21) 6434-6441. (2012) [PubMed]
  5. Chiba H, Oishi S, Fujii N, Ohno H.
    Total Synthesis of (–)-Quinocarcin by Gold(I)-Catalyzed Regioselective Hydroamination.
    Angew. Chem., Int. Ed. 51(36) 9169-9172. (2012) [PubMed]
  6. Naoe S, Suzuki Y, Hirano K, Inaba Y, Oishi S, Fujii N, Ohno H.
    Gold(I)-Catalyzed Regioselective Inter-/Intramolecular Addition Cascade of Di- and Triynes for Direct Construction of Substituted Naphthalenes.
    J. Org. Chem. 77(11) 4907-4916. (2012) [PubMed]
  7. Otani Y, Kijima T, Kohmo S, Oishi S, Minami T, Nagatomo I,Takahashi R, Hirata H, Suzuki M, Inoue K, Takeda Y, Kida H,Tachibana I, Fujii N, Kumanogoh A.
    A. Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016.
    FEBS Lett. 586(20) 3639-3644. (2012) [PubMed]
  8. Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii, N.
    Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles.
    Org. Biomol. Chem. 10(33) 6792-6802. (2012) [PubMed]
  9. Li X, Qian H, Miyamoto F, Naito T, Kawaji K, Kajiwara K, Hattori T, Matsuoka M, Watanabe K, Oishi S, Fujii N, Kodama EN.
    A simple, rapid, and sensitive system for the evaluation of anti-viral drugs in rats.
    Biochem. Biophys. Res. Commun. 424(2)257-261. (2012) [PubMed]
  10. Murata K, Kitaori T, Oishi S, Watanabe N, Yoshitomi H, Tanida S, Ishikawa M, Kasahara T, Shibuya H, Fujii N, Nagasawa T, Nakamura T, Ito H.
    Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy.
    PLoS One. 7(5) e37163. (2012) [PubMed]
  11. Suzuki Y, Oishi S, Takei Y, Yasue M, Misu R, Naoe S, Hou Z, Kure T, Nakanishi I, Ohno H, Hirasawa A, Tsujimoto G, Fujii N.
    Design and synthesis of novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles.
    Org. Biomol. Chem. 10(25) 4907-4915. (2012) [PubMed]
  12. Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Yano Y, Matsuzaki K, Navenot J, Peiper S, Fujii N.
    Paradoxical downregulation of CXC chemokine receptor 4 induced by polyphemusin II-derived antagonists.
    Bioconjug. Chem. 23(6) 1259-1265. (2012) [PubMed]
  13. Navenot JM, Evans B, Oishi S, Setsuda S, Fujii N, Peiper SC.
    The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma.
    Melanoma Res. 22(2) 140-150. (2012) [PubMed]
  14. Hou Z, Nakanishi I, Kinoshita T, Takei Y, Yasue M, Misu R, Suzuki Y, Nakamura S, Kure T, Ohno H, Murata K, Kitaura K, Hirasawa A, Tsujimoto G, Oishi S, Fujii N.
    Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds.
    J. Med. Chem. 55(6) 2899-2903. (2012) [PubMed].
  15. Kobayashi K, Oishi S, Hayashi R, Tomita K, Kubo T, Tanahara N, Ohno H, Yoshikawa Y, Furuya T, Hoshino M, Fujii N.
    Structure–activity relationship study of a CXC chemokine receptor type 4 (CXCR4) antagonist FC131 using a series of alkene dipeptide isosteres.
    J. Med. Chem. 55(6) 2746-2757. (2012) [PubMed]
  16. Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Kodama E, Matsuoka M, Fujii N.
    Development and application of fluorescent SDF-1 derivatives.
    Future Med. Chem. 4(7) 837-844. (2012) [PubMed]
  17. Kobayashi K, Oishi S, Kobayashi Y, Ohno H, Tsutsumi H, Hata Y, Fujii N.
    Synthesis and application of an Nδ-acetyl-Nδ-hydroxyornithine analog: identification of novel metal complexes of deferriferrichrysin.
    Bioorg. Med. Chem. 20(8) 2651-2655. (2012) [PubMed]
  18. Yoshikawa Y, Kobayashi K, Oishi S, Fujii N, Furuya T.
    Molecular modeling study of cyclic pentapeptide CXCR4 antagonists: New insight into CXCR4-FC131 interactions.
    Bioorg. Med. Chem. Lett. 22(6) 2146-2150. (2012) [PubMed]
  19. Sekiya A, Oishi S, Fujii N, Koide T.
    High-throughput turbidimetric screening for heparin-neutralizing agents and low-molecular-weight heparin mimetics.
    Chem. Pharm. Bull. 60(3) 371-376. (2012) [PubMed]
  20. Hou Z, Suzuki Y, Oishi S, Fujii N, Ohno H.
    Efficient synthesis of aminomethylated azaindoles and corresponding pyrrole-fused derivatives by copper-catalyzed domino multicomponent coupling and cyclization.
    Tetrahedron, 68(6) 1695-1703. (2012)
  21. Suzuki Y, Naoe S, Oishi S, Fujii N, Ohno H.
    Gold-catalyzed three-component annulation: efficient synthesis of highly Functionalized dihydropyrazoles from alkynes, hydrazines, and aldehydes or ketones.
    Org. Lett. 14(1) 326-329. (2012) [PubMed]
  22. Buckle T, Van den Berg N.S., Kuil J, Bunschoten A, Oldenburg J, Borowsky A. D., Wesseling J, Masada R, Oishi S, Fujii N, Van Leeuwen F.B.
    Non-invasive longitudinal imaging of tumor progression using an 111Indium labeled CXCR4 peptide antagonist.
    Am. J. Nucl. Med. Mol. Imaging, 2(1) 99-109. (2012)

2011

  1. Inoue N, Sasagawa K, Ikai K, Sasaki Y, Tomikawa J, Oishi S, Fujii N, Uenoyama Y, Ohmori Y, Yamamoto N, Hondo E, Maeda K, Tsukamura H.
    Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus).
    Proc Natl Acad Sci USA. 108(42) 17527-17532. (2011) [PubMed]
  2. Hirano K, Inaba Y, Takasu K, Oishi S, Takemoto Y, Fujii N, Ohno H.
    Gold(I)-catalyzed polycyclizations of polyenyne-type anilines based on hydroamination and consecutive hydroarylation cascade.
    J. Org. Chem. 76(21) 9068-9080. (2011) [PubMed]
  3. Ohno H, Yamamoto M, Iuchi M, Fujii N, Tanaka T.
    Palladium-catalyzed construction of polycyclic heterocycles by an alkyne insertion and direct arylation cascade.
    Synthesis (16) 2567-2578 (2011).
  4. Kinoshita T, Sekiguchi Y, Fukada H, Nakaniwa T, Tada T, Nakamura S, Kitaura K, Ohno H, Suzuki Y, Hirasawa A, Nakanishi I, Tsujimoto G.
    A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase.
    Mol. Cell. Biochem. 356(1-2) 97-105. (2011) [PubMed]
  5. Yoshimitsu Y, Oishi S, Miyagaki J, Inuki S, Ohno H, Fujii N.
    Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C.
    Bioorg. Med. Chem. 19(18) 5402-5408. (2011) [PubMed]
  6. Nishizawa K, Nishiyama H, Matsui Y, Kobayashi T, Kotani H, Masutani H, Oishi S, Saito R, Toda Y, Fujii N, Yodoi J, Ogawa O.
    Thioredoxin interacting protein suppresses bladder carcinogenesis.
    Carcinogenesis. 32(10) 1459-1466. (2011) [PubMed]
  7. Izumi K, Watanabe K, Oishi S, Fujii N, Matsuoka M, Sarafianosc SG, Kodama E.
    Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effect on T-20.
    Antivir. Chem. Chemother. 22(1) 51-55. (2011) [PubMed]
  8. Takeuchi T, Oishi S, Watanabe T, Ohno H, Sawada J, Matsuno K, Asai A, Asada N, Kitaura K, Fujii N.
    Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.
    J. Med. Chem. 54(13) 4839-4846. (2011) [PubMed]
  9. Iwata A, Inuki S, Oishi S, Fujii N, Ohno H.
    Formal total synthesis of (+)-Lysergic acid via zinc(II)-mediated regioselective ring-opening reduction of 2-alkynyl-3-indolyloxirane.
    J. Org. Chem. 76(13) 5506-5512. (2011) [PubMed]
  10. Tokimizu Y, Ohta Y, Chiba H, Oishi S, Fujii N, Ohno H.
    Direct synthesis of highly fused perimidines by copper(I)-catalyzed hydroamination of 2-ethynylbenzaldehydes.
    Tetrahedron 67(29) 5168-5175. (2011) [PubMed]
  11. Kuil J, Buckle T,Yuan H, van den Berg N. S, Oishi S, Fujii N, Josephson L, van Leeuwen F. W. B.
    Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide.
    Bioconjug. Chem. 22(5) 859-864. (2011) [PubMed]
  12. Xu C, Liu J, Chen L, Liang S, Fujii N, Tamamura H, Xiong H.
    HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase a signaling in cultured rat microglia.
    Glia. 59(6) 997-1007. (2011) [PubMed]
  13. Yamada M, Kubo H, Kobayashi S, Ishizawa K, He M, Suzuki T, Fujino N, Kunishima H, Hatta M, Nishimaki K, Aoyagi T, Tokuda K, Kitagawa M, Yano H, Tamamura H, Fujii N, Kaku M.
    The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury.
    Cell Mol. Immunol. 8(4) 305-314.(2011) [PubMed]
  14. Masuda R., Oishi S., Ohno H., Kimura H., Saji H., Fujii, N.
    Concise site-specific synthesis of DTPA-peptide conjugates: application to imaging probes for the chemokine receptor CXCR4.
    Bioorg. Med. Chem. 19(10) 3216-3220. (2011) [PubMed]
  15. Inokuchi E., Oishi S., Kubo T., Ohno H., Shimura K., Matsuoka M., Fujii, N.
    Potent CXCR4 antagonists containing amidine-type peptide bond isosteres.
    ACS Med. Chem. Lett. 2(6) 477-480. (2011)
  16. Xing N. D., Ding S. T., Saito R., Nishizawa K., Kobayashi T., Inoue T., Oishi S., Fujii N., Lv J. J., Ogawa O., Nishiyama, H.
    A potent chemotherapeutic strategy in prostate cancer: S-(methoxytrityl)-L-cysteine, a novel Eg5 inhibitor.
    Asian J. Androl. 13(2) 236-241. (2011) [PubMed]
  17. Inokuchi E., Yamada A., Hozumi K., Tomita K., Oishi S., Ohno H., Nomizu M., Fujii N.
    Design and synthesis of amidine-type peptide bond isostere: application of nitrile oxide derivatives as active ester equivalents to peptide and peptidomimetics synthesis.
    Org. Biomol. Chem. 9(9) 3421-3427. (2011) [PubMed]
  18. Dar A., Schajnovitz A., Lapid K., Kalinkovich A., Itkin T., Ludin A., Kao W., Battista M., Tesio M., Kollet O., Cohen N. N., Margalit R., Buss E. C., Baleux F., Oishi S., Fujii N., Larochelle A., Dunbar C. E., Broxmeyer H. E., Frenette P. S., Lapidot, T.
    Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.
    Leukemia. 25(8) 1286-1296. (2011) [PubMed]
  19. Kang HS., Baba T., Mandai M., Matsumura N., Hamanishi J., Kharma B., Kondoh E., Yoshioka Y., Oishi S., Fujii N., Murphy SK., Konishi I.
    GPR54 is a target for suppression of metastasis in endometrial cancer.
    Mol Cancer Ther. 10(4) 580-590. (2011) [PubMed]
  20. Inuki S., Iwata A., Oishi S., Fujii N., Ohno H.
    Enantioselective total synthesis of (+)-Lysergic acid, (+)-Lysergol, and (+)-Isolysergol by palladium-catalyzed domino cyclization of allenes bearing amino and bromoindolyl groups.
    J. Org. Chem. 76(7) 2072-2083. (2011) [PubMed]
  21. Hirano K., Inaba Y., Takahashi N., Shimano M., Oishi S., Fujii N., Ohno H.
    Direct synthesis of fused-indoles by gold-catalyzed cascade cyclization of diynes.
    J. Org. Chem. 76(5) 1212-1227. (2011) [PubMed]
  22. Noda M., Omatsu Y., Sugiyama T., Oishi S., Fujii N., Nagasawa T.
    CXCL12-CXCR4 chemokine signaling is essential for NK cell development in adult mice.
    Blood 117(2) 451-458. (2011) [PubMed]
  23. Oishi S., Misu R., Setsuda S., Masuda R., Ohno H., Naniwa Y., Ieda N., Inoue N., Ohkura S., Uenoyama Y., Tsukamura H., Maeda K., Hirasawa A., Tsujimoto G., Fujii N.
    Activation of neuropeptide FF receptors by kisspeptin receptor ligands.
    ACS Med. Chem. Lett. 2(1) 53-57. (2011) [PubMed]

2010

  1. Gravel S., Malouf C., Boulais P.E., Berchiche Y.A., Oishi S., Fujii N., Leduc R., Sinnett D., Heveker N.
    The peptidomimetic CXCR4 antagonist TC14012 recruits β-arrestin to CXCR7 roles of receptor domains.
    J. Biol. Chem. 285(49) 37939-37943. (2010) [PubMed]
  2. Shimura K., Nameki D., Kajiwara K., Watanabe K., Sakagami Y., Oishi S., Fujii N., Matsuoka M.., Sarafianos S.G., Kodama E.
    Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors.
    J. Biol. Chem. 285(50) 39471-39480. (2010) [PubMed]
  3. Martin S.K, Diamond P., Williams S.A., To L.B., Peet D.J., Fujii N., Gronthos S., Harris A.L., Zannettino A.C.
    Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.
    Haematologica. 95(5) 776-784. (2010) [PubMed]
  4. Mandawat A., Fiskus W., Buckley K.M., Robbins K., Rao R., Balusu R., Navenot J.M., Wang Z.X., Ustun C., Chong D.G., Atadja P., Fujii N., Peiper S.C., Bhalla K.
    Pan-histone deacetylase (HDAC) inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic anti-myeloid activity in combination with CXCR4 antagonists.
    Blood 116(24) 5306-5315. (2010) [PubMed]
  5. Omatsu Y., Sugiyama T., Kohara H., Kondoh G., Fujii N., Kohno K., Nagasawa T.
    The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche.
    Immunity 33(3) 387-399. (2010) [PubMed]
  6. Ohta Y., Tokimizu Y., Oishi S., Fujii N., and Ohno H.
    Direct synthesis of quinazolines through copper-catalyzed reaction of aniline-derived benzamidines.
    Org. Lett. 12(17) 3963-3965. (2010) [PubMed]
  7. Ding S., Nishizawa K., Kobayashi T., Oishi S., Lv J., Fujii N., Ogawa O., Nishiyama H.
    A potent chemotherapeutic strategy for bladder cancer: (S)-methoxy-trityl-L-cystein, a novel Eg5 inhibitor.
    J Urol. 184(3) 1175-1181. (2010) [PubMed]
  8. Oishi S., Watanabe K., Ito S.; Tanaka M.; Nishikawa H.; Ohno H.; Shimane K.; Izumi K.; Sakagami Y.; Kodama E. N.; Matsuoka M.; Asai A.; Fujii N.
    Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants.
    Med. Chem. Commn. 1(4) 276-281. (2010)
  9. Oishi S., Watanabe T., Sawada J., Asai A., Ohno H., Fujii N.
    Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.
    J. Med. Chem. 53(13) 5054-5058. (2010) [PubMed]
  10. Inuki S., Yoshimitsu Y., Oishi S., Fujii N., Ohno H.
    Ring-construction/stereoselective functionalization cascade: total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of propargyl chlorides and carbonates.
    J. Org. Chem. 75(11) 3831-3842. (2010) [PubMed]
  11. Izumi K., Nakamura S., Nakano H., Shimura K., Sakagami Y., Oishi S., Uchiyama S., Ohkubo T, Kobayashi Y., Fujii N., Matsuoka M., Kodama E.N.
    Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino terminal heptad repeat.
    Antiviral Res. 87(2) 179-186. (2010) [PubMed]
  12. Yoshimitsu Y., Inuki S., Oishi S., Fujii N., Ohno H.
    Stereoselective divergent synthesis of four diastereomers of pachastrissamine (jaspine B).
    J. Org. Chem. 75 3843-3846. (2010) [PubMed][Research]
  13. Okano A., Oishi S., Tanaka T., Fujii N., Ohno H.
    Construction of linked nitrogen heterocycles by palladium(0)-catalyzed intramolecular domino cyclization of 2-alkynylaziridines bearing a 2-aminoethyl group via ring expansion with isocyanate.
    J. Org. Chem. 75 3396-3400. (2010) [PubMed][Research]
  14. Okano A., Tsukamoto K., Kosaka S., Maeda H., Oishi S., Tanaka T., Fujii N., Ohno H.
    Synthesis of fused and linked bicyclic nitrogen heterocycles by palladium-catalyzed domino cyclization of propargyl bromides.
    Chem. Eur. J. 16(28) 8410-8418. (2010) [Research]
  15. Nishizawa K., Nishiyama H., Ohishi S., Tanahara N., Kotani H., Mikami Y., Toda Y., Evans BJ., Peiper SC., Saito R., Watanabe J., Fujii N., Ogawa O.
    Fluorescent imaging of high grade bladder cancer using a specific antagonist for chemokine receptor CXCR4.
    Int J Cancer. 127(5) 1180-1187. (2010) [PubMed]
  16. Melchionna R., Di Carlo A., De Mori R., Cappuzzello C., Barberi L., Musaro A., Cencioni C., Fujii N., Tamamura H., Crescenzi M., Capogrossi MC., Napolitano M., Germani A.
    Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors.
    Muscle Nerve. 41 828-835. (2010) [PubMed]
  17. Hirano K., Inaba Y., Watanabe T., Oishi S., Fujii N., Ohno H.
    Gold-catalyzed intramolecular alkyne cycloisomerization cascade: direct synthesis of aryl-annulated[a]carbazoles from aniline-substituted diethynylarenes.
    Adv. Syn. Catal. 352(2) 368-372. (2010) [Research]
  18. Narumi T., Hayashi R., Tomita K., Kobayashi K., Tanahara N., Ohno H., Naito T., Kodama E., Matsuoka M., Oishi S., Fujii N.
    Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres.
    Org. Biomol. Chem. 8(3) 616-621 (2010) [PubMed][Research]
  19. Mizuhara T., Oishi S., Fujii N., Ohno H.
    Efficient synthesis of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles by SNAr-Type C-S, C-N, or C-O bond formation with heterocumulenes.
    J. Org. Chem. 75(1) 265-268 (2010) [PubMed][Research]

2009

  1. Nakaniwa T., Kinoshita T., Sekiguchi Y., Tada T., Nakanishi I., Kitaura K., Suzuki Y., Ohno H., Hirasawa A., Tsujimoto G.
    Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor.
    Acta Crystallogr Sect F Struct Biol Cryst Commun. 65(Pt 2) 75-79 (2009) [PubMed]
  2. Kajiwara K., Watanabe K., Tokiwa R., Kurose T., Ohno H., Tsutsumi H., Hata Y., Izumi K., Kodama E., Matsuoka M., Oishi S., Fujii N.
    Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group.
    Bioorg. Med. Chem. 17(23) 7964-7970 (2009) [PubMed][Research]
  3. Tanaka M., Kajiwara K., Tokiwa R., Watanabe K., Ohno H., Tsutsumi H., Hata Y., Izumi K., Kodama E., Matsuoka M., Oishi S., Fujii N.
    Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins.
    Bioorg. Med. Chem. 17(21) 7487-7492 (2009) [PubMed][Research]
  4. Ohta Y, Chiba H, Oishi S, Fujii N, Ohno H.
    Construction of nitrogen heterocycles bearing an aminomethyl group by copper-catalyzed domino three-component coupling-cyclization.
    J. Org. Chem. 74(18) 7052-7058 (2009) [PubMed][Research]
  5. Inuki S.,Yoshimitsu Y., Oishi S., Fujii N., Ohno H.
    Ring-Construction/Stereoselective Functionalization Cascade: Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Bromoallenes.
    Org. Lett. 11(19) 4478-4481 (2009) [PubMed][Research]
  6. Watabe T., Terakawa Y., Watanabe K., Ohno H., Nakano H., Nakatsu T., Kato H., Izumi K., Kodama E., Matsuoka M., Kitaura K., Oishi S., Fujii N.
    X-ray crystallographic study of an HIV-1fusion inhibitor with the gp41 S138A substitution.
    J. Mol. Biol. 392(3) 657-665 (2009) [PubMed][Research]
  7. Arthur A, Shi S, Zannettino A. C, Fujii N, Gronthos S, Koblar S. A.
    Implanted adult human dental pulp stem cells induce endogenous axon guidance.
    Stem Cells. 27(9) 2229-2237 (2009) [PubMed]
  8. Ohta Y., Kubota Y., Watabe T., Chiba H., Oishi S., Fujii N., Ohno H.
    Rapid access to 3-(aminomethyl)isoquinoline-fused polycyclic compounds by copper-catalyzed four-component coupling, cascade cyclization, and oxidation.
    J. Org. Chem. 74(16) 6299-6302 (2009) [PubMed][Research]
  9. Tanaka T., Nomura W., Narumi T., Esaka A., Oishi S., Ohashi N., Itotani K., Evans B. J., Wang Z., Peiper S. C., Fujii N., Tamamura H.
    Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids.
    Org. Biomol. Chem. 7(18) 3805-3809 (2009) [PubMed]
  10. Oishi S., Kodera Y., Nishikawa H., Kamitani H., Watabe T., Ohno H., Tochikura T., Shimane K., Kodama E., Matsuoka M., Mizukoshi F., Tsujimoto H., Fujii N.
    Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus.
    Bioorg. Med. Chem. 17(14) 4916-4920 (2009) [PubMed][Research]
  11. Evans B.J., Wang Z., Broach J.R., Oishi S., Fujii N., Peiper S.C.
    Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists.
    Methods Enzymol. 460 399-412 (2009) [PubMed]
  12. Ueno M., Kodama E. N., Shimura K., Sakurai Y., Kajiwara K., Sakagami Y., Oishi S., Fujii N., Matsuoka M..
    Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide.
    Antiviral Res. 82(1) 67-72 (2009) [PubMed]
  13. Ohta Y., Oishi S., Fujii N., Ohno H.
    Facile synthesis of 1,2,3,4-tetrahydro-b-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization.
    Org. Lett. 11(9) 1979-1982 (2009) [PubMed][Research]
  14. Watanabe T., Oishi S., Fujii N., Ohno H.
    Palladium-catalyzed direct synthesis of carbazoles via one-pot N-arylation and oxidative biaryl coupling: synthesis and mechanistic study.
    J. Org. Chem. 74(13) 4270-4276 (2009) [PubMed][Research]
  15. Suzuki Y., Ohta Y., Oishi S., Fujii N., Ohno H.
    Efficient synthesis of aminomethylated pyrroloindoles and dipyrrolopyridines via controlled copper-catalyzed domino multi-component coupling and bis-cyclization.
    J. Org. Chem. 74(11) 4246-4251 (2009) [PubMed][Research]
  16. Kobayashi K., Narumi T., Oishi S., Ohno H., Fujii N.
    Amino acid-based synthesis of trifluoromethylalkene dipeptide isosteres by alcohol-assisted nucleophilic trifluoromethylation and organozinc-ccopper-mediated SN2' alkylation.
    J. Org. Chem. 74(12) 4626-4629 (2009) [PubMed][Research]
  17. Oishi S., Kamitani H., Kodera Y,. Watanabe K., Kobayashi K., Narumi T., Tomita K., Ohno H., Naito T., Kodama E., Matsuoka M., Fujii N.
    Peptide bond mimicry by (E)-alkene and (Z)-fluoroalkene peptide isosteres: synthesis and bioevaluation of a-helical anti-HIV peptide analogues.
    Org. Biomol. Chem. 7(14) 2872-2877 (2009) [PubMed][Research]
  18. Mizuhara T., Inuki S., Oishi S., Fujii N., Ohno H.
    Cu(II)-mediated oxidative intermolecular ortho C-H functionalisation using tetrahydropyrimidine as the directing group.
    Chem. Commun. (23) 3413-3415 (2009) [PubMed][Research]
  19. Navenot J.M., Fujii N., Peiper S.C.
    KiSS1 Metastasis Suppressor Gene Product Induces Suppression of Tyrosine Kinase Receptor Signaling to Akt, TNF Family Ligand Expression, and Apotosis.
    Mol. Pharmacol. (2009) [PubMed]
  20. Navenot J.M., Fujii N., Peiper S.C.
    Activation of Rho and ROCK by GPR54 and KiSS1 Metastasis Suppressor Gene Product Induces Changes of Cell Morphology and Contributes to Apotosis.
    Mol. Pharmacol. (2009) [PubMed]
  21. Diamond P., Labrinidis A., Martin S.K., Farrugia A.N., Gronthos S., To L.B., Fujii N., O’Loughlin P.D., Evdokiou A., Zannettino A.C.W.
    Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.
    J. Bone Miner. Res. 24(7) 1150-1561 (2009) [PubMed]
  22. Mizukoshi F., Baba K., Goto-Koshino Y., Setoguchi-Mukai A., Fujino Y., Ohno K., Tamamura H., Oishi S., Fujii N., Tsujimoto H.
    Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus.
    Vet. Microbiol. 71(1) 121-124 (2009) [PubMed]
  23. Naito T., Izumi K., Kodama E., Sakagami Y., Kajiwara K., Nishikawa H., Watanabe K., Sarafianos S.G., Oishi S., Fujii N., Matsuoka M.
    SC29EK, a peptide fusion inhibitor with enhanced a- helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide.
    Antimicrob. Agents Chemother. 53(3) 1013-1018 (2009) [PubMed]
  24. Izumi K., Kodama E., Shimura K., Sakagami Y., Watanabe K., Ito S., Watabe T., Terakawa Y., Nishikawa H., Sarafianos S. G., Kitaura K., Oishi S., Fujii N., Matsuoka M.
    Design of peptide- based inhibitors of HIV-1 strains resistant to T-20.
    J. Biol. Chem. 284(8) 4914-4920 (2009) [PubMed]
  25. Mizukoshi F., Baba F., Goto Y., Setoguchi A., Fujino Y., Ohno K., Oishi S., Kodera Y., Fujii N., Tsujimoto H.
    Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein.
    J. Vet. Med. Sci. 71(1) 121-124 (2009) [PubMed]
  26. Kitaori T., Ito H., Schwarz E.M., Tsutsumi R., Yoshitomi H., Oishi S., Nakano M., Fujii N., Nagasawa T., Nakamura T.
    SDF-1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair.
    Arthritis Rheum. 60(3) 813-823 (2009) [PubMed]
  27. Nishikawa H., Nakamura S., Kodama E., Ito S., Kajiwara K., Izumi K., Sakagami Y., Oishi S., Ohkubo T., Kobayashi Y., Otaka A., Fujii N., Matsuoka M.
    Electrostatically constrained α-helical peptide inhibitors replication of HIV-1 resistant to enfuvirtide.
    Int. J. Biochem. Cell Biol. 41(4) 891-899 (2009) [PubMed]
  28. Yamaki Y., Shigenaga A., Tomita K., Narumi T., Fujii N., Otaka A.
    Synthesis of fluoroalkene dipeptide isosteres by intramolecular redox reaction utilizing N-heteorocyclic carbenes (NHCs).
    J. Org. Chem. in press (2009) [PubMed]
  29. Katagiri F., Nagai K., Kida A., Tomita K., Oishi S., Takeyama M., Doi R., Fujii N.
    Clinical significance of plasma metastin level in pancreatic cancer patients.
    Oncol. Rep. 21(3) 815-819 (2009) [PubMed]
  30. Tomita K., Popiel H.A., Nagai Y., Toda T., Yoshimitsu Y., Ohno H., Oishi S., Fujii N
    Structure-activity relationship study on polyglutamine binding peptide QBP1.
    Bioorg. Med. Chem. 17(3) 1259-1263 (2009) [PubMed][Research]
  31. Nagai K., Doi R., Katagiri F., Ito T., Kida A., Koizumi M., Masui T., Kawaguchi Y., Tomita K., Oishi S., Fujii N., Uemoto S.
    Prognostic value of metastin expression in human pancreatic cancer.
    J. Exp. Clin. Cancer Res. 28(9) (2009) [PubMed]

2008

  1. Evans B.J., Wang Z., Mobley L., Khosravi D., Fujii N., Navenot J.M., Peiper S.C.
    Physical association of GPR54 C-terminal with protein phosphatase 2A.
    Biochem. Biophys. Res. Commun. 377(4) 1067-1071 (2008) [PubMed]
  2. Tanaka T., Tsutsumi H., Nomura W., Tanabe Y., Ohashi N., Esaka A., Ochiai C., Sato J., Itotani K., Murakami T., Ohba K., Yamamoto N., Fujii N., Tamamura H.
    Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore.
    Org. Biomol. Chem. 6(23) 4374-4377 (2008) [PubMed]
  3. Tomita K., Oishi S., Ohno H., Peiper S.C., Fujii N.
    Development of novel GPR54 agonists with resistance to degradation by matrix metalloproteinase.
    J. Med. Chem. 51(23) 7645-7649 (2008) [PubMed][Research]
  4. Nishikawa H., Oishi S., Fujita M., Watanabe K., Tokiwa R., Ohno H., Kodama E., Izumi K., Kajiwara K., Naitoh T., Matsuoka M., Otaka A., Fujii N.
    Identification of minimal sequence for HIV-1 fusion inhibitors.
    Bioorg. Med. Chem. 16(20) 9184-9187 (2008) [PubMed][Research]
  5. Inuki S., Oishi S., Fujii N., Ohno H.
    Total synthesis of (±)-lysergic acid, lysergol, and isolysergol by palladium-catalyzed domino cyclization of amino allenes bearing a bromoindolyl group.
    Org. Lett. 10(22) 5239-5242 (2008) [PubMed][Research]
  6. Mikami S., Nakase H., Yamamoto S., Takeda Y., Yoshino T., Kasahara K., Ueno S., Uza N., Oishi S., Fujii N., Nagasawa T., Chiba T.
    Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis.
    J. Pharmacol. Exp. Ther. 327(2) 383-392 (2008) [PubMed]
  7. Ohta Y., Chiba H., Oishi S., Fujii N., Ohno H.
    Concise synthesis of indole-fused 1,4-diazepines through copper(I)-catalyzed domino three-component coupling-cyclization-N-arylation under microwave irradiation.
    Org. Lett. 10(16) 3535-3538 (2008) [PubMed][Research]
  8. Yano Y, Yano A, Oishi S, Sugimoto Y, Tsujimoto G, Fujii N, Matsuzaki K.
    Coiled-coil tag-probe system for quick labeling of membrane receptors in living cells.
    ACS Chem. Biol. 3(6) 341-345 (2008) [PubMed]
  9. Ueda S., Kato M., Inuki S., Ohno H., Evans B., Wang Z., Peiper S.C., Izumi K., Kodama E., Matsuoka M., Nagasawa H., Oishi S., Fujii N.
    Identification of novel nonpeptide CXCR4 antagonists by ligand-based design approach.
    Bioorg. Med. Chem. Lett. 18(14) 4124-4129 (2008)[PubMed][Research]
  10. Okano A., Mizutani T., Oishi S., Tanaka T., Ohno H., Fujii N.
    Palladium-catalysed biscyclisation of allenic bromoalkenes through zipper-mode cascade.
    Chem. Commun. 30 3534-3536 (2008) [PubMed][Research]
  11. Nishikawa H., Kodama E., Sakakibara A., Fukudome A., Izumi K., Oishi S., Fujii N., Matsuoka M.
    Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp4.
    Antivir. Res. 80(1) 71-76(2008) [PubMed]
  12. Nakata H., Steinberg S.M., Koh Y., Maeda K., Takaoka Y., Tamamura H., Fujii N., Mitsuya H.
    Potent synergistic anti-HIV effects using combinations of a CCR5.
    Antimicrob. Agents. Chemother. 52(6) 2111-2119 (2008) [PubMed]
  13. Watanabe T., Oishi S., Fujii N., Ohno H.
    Palladium-catalyzed sp3 C－H activation of simple alkyl groups: direct preparation of indoline derivatives from N-alkyl-2-bromoanilines.
    Org. Lett. 10(9) 1759-1762 (2008) [Link][Research]
  14. Inokuchi E., Narumi T., Niida A., Kobayashi K., Tomita K., Oishi S., Ohno H., Fujii N.
    Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres by palladium-catalyzed carbonylation of amino acid-derived allylic carbonates.
    J. Org. Chem. 73(10) 3942-3945 (2008) [Link][Research]
  15. Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
    Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to Fmoc-based solid phase synthesis of a cyclic pentapeptide mimetic.
    Tetrahedron, 64(19) 4332-4346 (2008) [Research]
  16. Suzuki　Y., Cluzeau J., Hara T., Hirasawa A., Tsujimoto G., Oishi S., Ohno H., Fujii N.
    Structure-activity relationship of pyrazine-based CK2 inhibitors: synthesis and biological evaluation of 2,6-disubstituted pyrazine and 4,6-disubstituted pyrimidine derivatives.
    Archiv. Pharm. (Weinheim) 341(9) 554-561 (2008) [PubMed][Research]
  17. Ohno H., Okano A., Kosaka S., Tsukamoto K., Ohata M., Ishihara K., Maeda H., Tanaka T., Fujii N.
    Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides.
    Org. Lett. 10(6) 1171-1174 (2008) [PubMed][Research]
  18. Tomita K., Oishi S., Ohno H., Fujii N.
    Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists.
    Biopolymers, 90(4) 503-511 (2008) [PubMed][Research]
  19. Driessen W.H., Fujii N., Tamamura H., Sullivan S.M.
    Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells.
    Mol. Ther. 16(3) 516-524 (2008) [PubMed]
  20. Ohta Y., Oishi S., Fujii N., Ohno H.
    Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation.
    Chem. Commun. 7 835-837 (2008) [PubMed][Research]
  21. Oishi S., Masuda R., Evans B., Ueda S., Goto Y., Ohno H., Hirasawa A., Tsujimoto G., Wang Z., Peiper S.C., Naito T., Kodama E., Matsuoka M., Fujii N.
    Synthesis and application of fluorescein- and botin-labeled molecular probes for chemokine receptor CXCR4.
    ChemBioChem, 9(7) 1154-1158 (2008) [Link][Research]
  22. Kasiyanov A., Fujii N., Tamamura H., Xiong H.
    Modulation of network-driven, GABA-mediated giant depolarizing potentials by SDF-1α in the developing hippocampus.
    Dev. Neurosci. 30(4) 285-292 (2008) [PubMed]
  23. Oishi S., Ito S., Nishikawa H., Watanabe K., Tanaka M., Ohno H., Izumi K., Sakagami Y., Kodama E., Matsuoka M., Fujii N.
    Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity.
    J. Med. Chem. 51(3) 388-391 (2008)[PubMed][Research]
  24. Liapi A., Pritchett J., Jones O., Fujii N., Parnavelas J.G., Nadarajah B.
    Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex.
    Dev. Neurosci. 30(1-3) 117-131 (2008) [PubMed]
  25. Ujike M., Nishikawa H., Otaka A., Yamamoto N., Yamamoto N., Matsuoka M., Kodama E., Fujii N., Taguchi F.
    Heptad repeat-derived peptides block the protease-mediated direct entry from cell surface of SARS coronavirus but not entry via endosomal pathway.
    J. Virol. 82(1) 588-592 (2008) [Link][Research]

2007

  1. Sasaki Y., Fujii N., Otaka A.
    Development of copper-mediated allylation of γ-activated-α,β-unsaturated lactam toward peptide mimetic synthesis.
    Tetrahedron lett. 48(18) 3221-3224 (2007)  [Link][Research]
  2. Watanabe T., Ueda S., Inuki S., Oishi S., Fujii N., Ohno H.
    One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling.
    Chem. Commun. (43) 4516-4518 (2007)  [Link][Research]
  3. Watanabe T., Oishi S., Fujii N., Ohno H.
    Gold-catalyzed hydroarylation of allenes: a highly regioselective carbon-carbon bond formation producing six-membered rings.
    Org. Lett. 9(23) 4821-4824 (2007)  [Link][Research]
  4. Ohno H., Iuchi M., Fujii N., Tanaka T.
    Zipper-mode double C-H activation: palladium-catalyzed direct construction of highly-fused heterocyclic systems.
    Org. Lett. 9(23) 4813-4815(2007)  [Link][Research]
  5. Kohara H., Omatsu Y., Sugiyama T., Noda M., Fujii N., Nagasawa T.
    Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling.
    Blood, 110(13) 4153-4160(2007)  [Link]
  6. Kabashima K., Shiraishi N., Sugita K., Mori T., Onoue A., Kobayashi M., Sakabe JI., Yoshiki R., Tamamura H., Fujii N., Inaba K., Tokura Y.
    CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.
    Am. J. Pathol. 171(4) 1249-1257(2007)  [Link]
  7. Zhang W., Navenot J.M., Frilot N.M., Fujii N., Peiper S.C.
    Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis.
    Mol. Pharmacol. 72(5) 1310-1321 (2007)  [Link]
  8. Tamamura H., Tanaka T., Tsutsumi H., Nemoto K., Mizokami S., Ohashi N., Oishi S., Fujii N.
    Versatile use of acid-catalyzed ring-opening of&beta-aziridinyl-&alpha,β enoates to stereoselective synthesis of peptidomimetics.
    Tetrahedron, 63(37) 9243-9254 (2007)  [Link][Research]
  9. Kabashima K., Sugita K., Shiraishi N., Tamamura H., Fujii N., Tokura Y.
    CXCR4 engagement promotes dendritic cell survival and maturation.
    Biochem. Biophys. Res. Commun. 361(4) 1012-1016 (2007)  [Link]
  10. Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
    Facile synthesis of fluoroalkenes by palladium-catalyzed reductive defluorination of allylic gem-difluorides.
    Org. Lett. 9(17) 3465-3468 (2007)  [Link][Research]
  11. Ohno H., Aso A., Kadoh Y., Fujii N., Tanaka T.
    Heck-type cyclization of oxime ethers: stereoselective carbon-carbon bond formation with aryl halides to produce heterocyclic oximes.
    Angew. Chem. Int. Ed. 46(33) 6325-6328 (2007)  [Link][Research]
  12. Kubonishi S., Kikuchi T., Yamaguchi S., Tamamura H., Fujii N., Watanabe T., Arenzana-Seisdedos F., Ikeda K., Matsui T., Tanimoto M., Katayama Y.
    Rapid hematopoietic progenitor mobilization by sulfated colominic acid.
    Biochem. Biophys. Res. Commun. 355(4) 970-975 (2007)  [Link]
  13. Cluzeau J., Oishi S., Ohno H., Wang Z., Evans B., Peiper S.C., Fujii N.
    Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists.
    Org. Biomol. Chem. 5(12) 1915-1923 (2007)  [Link][Research]
  14. Ohno H., Mizutani T., Kadoh Y., Aso A., Miyamura K., Fujii N., Tanaka T.
    A highly regio- and stereoselective formation of bicyclo[4.2.0]oct-5-ene derivatives through thermal intramolecular [2 + 2] cycloaddition of allenes.
    J. Org. Chem. 72(12) 4378-4389 (2007)  [Link][Research]
  15. Ono Y., Kashiwagi H., Esaki T., Tadakatsu T., Sato H., Fujii N.
    Systematic solution-phase parallel synthesis of active vitamin D3 analogs with elongated side chains and their cell differentiation activities.
    J. Comb. Chem. 9(4) 711-716 (2007)  [Link]
  16. Ogo N., Oishi S., Matsuno K., Sawada J., Fujii N., Asai A.
    Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.
    Bioorg. Med. Chem. Lett. 17(14) 3921-3924 (2007)  [Link]
  17. Tomita K., Oishi S., Cluzeau J., Ohno H., Navenot J.M., Wang Z.X., Peiper S.C., Akamatsu M., Fujii N.
    SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54.
    J. Med. Chem. 50(14) 3222-3228 (2007)  [Link][Research]
  18. Katagiri F., Tomita K., Oishi S., Takeyama M., Fujii N.
    Establishment and clinical application of enzyme immunoassays for determination of luteinizing hormone releasing hormone and metastin.
    J. Pept. Sci. 13(6) 422-429 (2007)  [Link][Research]
  19. Juarez J., Dela Pena A., Baraz R., Hewson J., Khoo M., Cisterne A., Fricker S., Fujii N., Bradstock K.F., Bendall L.J.
    CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment.
    Leukemia, 21(6) 1249-1257 (2007)  [Link]
  20. Berchiche Y.A., Chow K.Y., Lagane B., Leduc M., Percherancier Y., Fujii N., Tamamura H., Bachelerie F., Heveker N.
    Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and Gαi activation.
    J. Biol. Chem. 282(8) 5111-5115 (2007)  [Link]
  21. Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
    Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres.
    Biopolymers. 88(2) 272-278 (2007)  [Link][Research]
  22. Ohno H., Ohta Y., Oishi S., Fujii N.
    Direct synthesis of 2-(aminomethyl)indoles through copper(I)-catalyzed domino three-component coupling and cyclization reactions.
    Angew. Chem. Int. Ed. 46(13) 2295-2298 (2007)  [Link][Research]
  23. Ueda S., Oishi S., Wang Z.X., Araki T., Tamamura H., Cluzeau J., Ohno H., Kusano S., Nakashima H., Trent J.O., Peiper S.C., Fujii N.
    Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.
    J. Med. Chem. 50(2) 192-198 (2007)  [Link][Research]
  24. Hamaguchi H., Kosaka S., Ohno H., Fujii N., Tanaka T.
    Bromoallenes as allyl dication equivalents in the presence or absence of palladium(0): direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes.
    Chem. Eur. J. 13(6) 1692-1708 (2007)  [Link][Research]
  25. Tanaka M., Oishi S., Ohno H., Fujii N.
    A novel oxazolidine linker for the synthesis of peptide aldehydes.
    Int. J. Pep. Res. Ther. 13(1-2) 271-279(2007) [Link][Research]
  26. Sasaki Y., Shigenaga A., Fujii N., Otaka A.
    Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium (II) diiodide (SmI2)-mediated reductive-alkylation reaction.
    Tetrahedron, 63(9) 2000-2008(2007) [Link]
  27. Kang S.-U., Choi W. J., Oishi S., Lee K., Karki R.G., Worthy K.M., Bindu L.K., Nicklaus M.C., Fisher R.J., Burke T.R.Jr.
    Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the pTyr+1 position of Grb2 SH2 domain-binding tripeptides.
    J. Med. Chem. 50(8) 1978-1982(2007) [Link]
  28. Kato-Takagaki K., Suzuki N., Yokoyama F., Takaki D., Umezawa K., Higo J., Mochizuki M., Kikkawa Y., Oishi S., Utani A., Nomizu M.
    Cyclic peptide analysis of the biologically active loop region in the laminin R3 chain LG4 module demonstrates the importance of peptide conformation on biological activity.
    Biochemistry, 46(7) 1952-1960(2007) [Link]

2006

  1. Narumi T., Niida A., Tomita K., Oishi S., Otaka A., Ohno H., Fujii N.
    A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres.
    Chem. Commun. (45) 4720-4722 (2006)  [Link][Research]
  2. Tomita K., Niida A., Oishi S., Ohno H., Cluzeau J., Navenot J.M., Wang Z.X., Peiper S.C., Fujii N.
    Structure-activity relationship study on small peptidic GPR54 agonists.
    Bioorg. Med. Chem. 14(22) 7595-7603 (2006)  [Link][Research]
  3. Sasaki Y., Niida A., Tsuji T., Shigenaga A., Fujii N., Otaka A.
    Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics.
    J. Org. Chem. 71(13) 4969-4979 (2006)  [Link][Research]
  4. Niida A., Tanigaki H., Inokuchi E., Sasaki Y., Oishi S., Ohno H., Tamamura H., Wang Z., Peiper S.C., Kitaura K., Otaka A., Fujii N.
    Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists.
    J. Org. Chem. 71(10) 3942-3951 (2006)  [Link][Research]
  5. Niida A., Mizumoto M., Narumi T., Inokuchi E., Oishi S., Ohno H., Otaka A., Kitaura K., Fujii N.
    Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations.
    J. Org. Chem. 71(11) 4118-4129 (2006)  [Link][Research]
  6. Hanaoka H., Mukai T., Tamamura H., Mori T., Ishino S., Ogawa K., Iida Y., Doi R., Fujii N., Saji H.
    Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors.
    Nucl. Med. Biol. 33(4) 489-494 (2006)  [Link]
  7. Tamamura H., Ojida A., Ogawa T., Tsutsumi H., Masuno H., Nakashima H., Yamamoto N., Hamachi I., Fujii N.
    Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.
    J. Med. Chem. 49(11) 3412-3415 (2006)  [Link][Research]
  8. Tamamura H., Tsutsumi H., Masuno H., Mizokami S., Hiramatsu K., Wang Z., Trent J.O., Nakashima H., Yamamoto N., Peiper S.C., Fujii N.
    Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.
    Org. Biomol. Chem. 4(12) 2354-2357 (2006)  [Link][Research]
  9. Tsuda M., Terada T., Irie M., Katsura T., Niida A., Tomita K., Fujii N., Inui K.
    Transport characteristics of a novel PEPT1 substrate, antihypotensive drug midodrine, and its amino acid derivatives.
    J. Pharmacol. Exp. Ther. 318(1) 455-460 (2006)  [Link]
  10. Menu E., Asosingh K., Indraccolo S., De Raeve H., Van Riet I., Van Valckenborgh E., Van de Broek I., Fujii N., Tamamura H., Van Camp B., Vanderkerken K.
    The involvement of stromal derived factor 1α in homing and progression of multiple myeloma in the 5TMM model.
    Haematologica, 91(5) 605-612 (2006)  [Link]
  11. Kasyanov A., Tamamura H., Fujii N., Xiong H.
    HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rat hippocampus.
    Eur. J. Neurosci. 23(5) 1120-1128 (2006)  [Link]
  12. Niida A., Tomita K., Mizumoto M., Tanigaki H., Terada T., Oishi S., Otaka A., Inui K., Fujii N.
    Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural reuirements of the peptide transporter PEPT1.
    Org. Lett. 8(4) 613-616 (2006)  [Link][Research]
  13. Ohta Y., Itoh S., Shigenaga A., Shintaku S., Fujii N., Otaka A.
    Cysteine-derived S-protected oxazolidinones: potential chemical devices for the preparation of peptide thioesters.
    Org. Lett. 8(3) 467-470 (2006)  [Link][Research]
  14. Ohno H., Kadoh Y., Fujii N., Tanaka T.
    Potassium carbonate-promoted stereospecific 5-endo-trig cyclization of unactivated allenes in the absence of any transition metals.
    Org. Lett. 8(5) 947-950 (2006)  [Link][Research]
  15. Oishi S., Miyamoto K., Niida A., Yamamoto M., Ajito K., Tamamura H., Otaka A., Kuroda Y., Asai A., Fujii N.
    Application of tri- and tetrasubstituted alkene dipeptide mimetics to conformational studies of cyclic RGD peptides.
    Tetrahedron, 62(7) 1416-1424 (2006)  [Link]
  16. Avniel S., Arik Z., Maly A., Sagie A., Basst H.B., Yahana M.D., Weiss I.D., Pal B., Wald O., Ad-El D., Fujii N., Arenzana-Seisdedos F., Jung S., Galun E., Gur E., Peled A.
    Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns.
    J. Invest. Dermatol. 126(2) 468-476 (2006)  [Link]
  17. Dewan M.Z., Uchihara J.N., Terashima K., Honda M., Sata T., Ito M., Fujii N., Uozumi K., Tsukasaki K., Tomonaga M., Kubuki Y., Okayama A., Toi M., Mori N., Yamamoto N.
    Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir.
    Blood, 107(2) 716-724 (2006)  [Link]
  18. Niida A., Wang Z., Tomita K., Oishi S., Tamamura H., Otaka A., Navenot J.M., Broach J.R., Peiper S.C., Fujii N.
    Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity.
    Bioorg. Med. Chem. Lett. 16(1) 134-137 (2006)  [Link][Research]
  19. Baba M., Hong S.-B., Sharma N., Warren M.B., Nickerson M.L., Iwamatsu A., Esposito D., Gillette W.K., Hopkins R.F.III, Hartley J.L., Furihata M., Oishi S., Zhen W., Burke T.R.Jr., Linehan W.M., Schmidt L.S., Zbar B.
    Folliculin encoded by the BHD gene interacts with a novel binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.
    Proc. Natl. Acad. Sci. 103(42) 15552-15557 (2006)  [Link]
  20. Tanaka T., Yamamoto S., Hiramatsu K., Murakami K., Yoshino H., Debasis P., Iwata C., Ohno H.
    Construction of tricyclic enone, a common precursor for aphidicolane and stemodane B/C/.D-ring system.
    Chem. Phram. Bull. 54(8) 1138-1143 (2006)  [Link]

2005

  1. Navenot J.M., Wang Z., Chopin M., Fujii N., Peiper S.C.
    Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins.
    Cancer Res. 65, 10450-10456(2005) [Link]
  2. Tamamura H., Esaka A., Ogawa T., Araki T., Ueda S., Wang Z., Trent J.O., Tsutsumi H., Masuno H., Nakashima H., Yamamoto N., Peiper S.C., Otaka A., Fujii N.
    Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.
    Org. Biomol. Chem. 3, 4392-4394 (2005) [Link]
  3. Zhong Y., Yoshinaka Y., Takeda T., Shimizu N., Yoshizaki S., Inagaki Y., Matsuda S., Honda G., Fujii N., Yamamoto N.
    Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton.
    Antivir. Res. 66(2-3) 119-128 (2005) [Link]
  4. Retz M., Sidhu S.S., Lehmann J., Tamamura H., Fujii N., Basbaum C.
    New HIV-drug inhibits in vitro bladder cancer migration and invasion.
    Eur. Urol. 48(6) 1025-1030 (2005) [Link]
  5. Ueda S., Fujita M., Tamamura H., Fujii N., Otaka A.
    Photolabile protection for one-pot sequential native chemical ligation.
    Chembiochem, 6(11) 1983-1986 (2005) [Link]
  6. Hartmann TN., Burger J.A., Glodek A., Fujii N., Burger M.
    CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.
    Oncogene, 24, 4462-4471 (2005) [Link]
  7. Niida A., Oishi S., Sasaki Y., Mizumoto M., Tamamura H., Fujii N., Otaka A.
    Facile access to (Z)-alkene-containing diketopiperazine mimetics utilizing organocopper-mediated anti-SN2' reactions.
    Tetrahedron Lett. 46(24) 4183-4186 (2005) [Link]
  8. Burger M., Hartmann T., Krome M., Rawluk J., Tamamura H., Fujii N., Kipps T.J., Burger J.A.
    Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.
    Blood, 106(5) 1824-1830 (2005) [Link]
  9. Tamamura H., Araki T., Ueda S., Wang Z., Oishi S., Esaka A., Trent J.O., Nakashima H., Yamamoto N., Peiper S.C., Otaka A., Fujii N.
    Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.
    J. Med. Chem. 48(9) 3280-3289 (2005) [Link]
  10. Bhonsle J.B., Wang Z., Tamamura H., Fujii N., Peiper S.C., Trent J.O.
    A simple, automated quasi-4D-QSAR, quasi-multi way PLS approach to develop highly predictive QSAR Models for highly flexible CXCR4 inhibitor cyclic peptide ligands using scripted common molecular modeling tools.
    QSAR Comb. Sci. 24(5) 620-630 (2005) [Link]
  11. Ichikawa N., Kasai S., Suzuki N., Nishi N., Oishi S., Fujii N., Kadoya Y., Hatori K., Mizuno Y., Nomizu M., Arikawa-Hirasawa E.
    Identification of neurite outgrowth active sites on the laminin α4 chain G domain.
    Biochemistry, 44(15) 5755-5762 (2005) [Link]
  12. Percherancier Y., Berchiche Y., Slight I., Volkmer-Engert R., Tamamura H., Fujii N., Bouvier M., Heveker N.
    Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers.
    J. Biol. Chem. 280(11) 9895-9903 (2005) [Link]
  13. Nameki D., Kodama E., Ikeuchi M., Mabuchi N., Otaka A., Tamamura H., Ohno M., Fujii N., Matsuoka M.
    Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and rev-responsive element functions.
    J. Virol. 79(2) 764-770 (2005) [Link]
  14. Zannettino A.C., Farrugia A.N., Kortesidis A., Manavis J., To L.B., Martin S.K., Diamond P., Tamamura H., Lapidot T., Fujii N., Gronthos S.
    Elevated serum levels of stromal-derived factor-1α are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients.
    Cancer Res. 65 1700-1709 (2005) [Link]
  15. Tamamura H., Hiramatsu K., Ueda S., Wang Z., Kusano S., Terakubo S., Trent J.O., Peiper SC., Yamamoto N., Nakashima H., Otaka A., Fujii N.
    Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.
    J. Med. Chem. 48(2) 380-391 (2005) [Link]
  16. Piovan E., Tosello V., Indraccolo S., Cabrelle A., Baesso I., Trentin L., Zamarchi R., Tamamura H., Fujii N., Semenzato G., Chieco-Bianchi L., Amadori A.
    Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
    Blood, 105(3) 931-939 (2005) [Link]
  17. Ohno H., Mizutani T., Kadoh Y., Miyamura K., Tanaka T.
    Thermal intramolecular [2 + 2] cycloaddition of allenenes and allenynes: diastereoselective access to bicyclic nitrogen heterocycle.
    Angew. Chem. Int. Ed. 44(32) 5113-5115 (2005) [Link]
  18. Ohno H., Yamamoto M., Iuchi M., Tanaka T.
    Palladium-catalyzed tandem cyclization of bromoenynes through aromatic C-H bond functionalizatin.
    Angew. Chem. Int. Ed. 44(32) 5103-5106 (2005) [Link]
  19. Tanaka T., Hiramatsu K., Kobayashi Y., Ohno H.
    Chemo- and stereoselectivity in titanium-mediated regioselective ring-opening reaction of epoxides at the more substituted carbon.
    Tetrahedron, 61(28) 6726-6742 (2005) [Link]
  20. Ohno H., Miyamura K., Mizutani T., Kadoh Y., Takeoka Y., Hamaguchi H., Tanaka T.
    Palladium(0)-catalyzed tandem cyclization of allenenes: direct construction of tricyclic heterocycles through aromatic C-H activation.
    Chem. Eur. J. 11(12) 3728-3741 (2005) [Link]
  21. Hamaguchi H., Kosaka S., Ohno H., Tanaka T.
    Bromoallenes as allyl dication equivalents in the absence of palladium(0): synthesis of bicyclic sulfamides by tandem cyclization of bromoallenes.
    Angew. Chem. Int. Ed. 44(10) 1513-1517 (2005) [Link]
  22. Oishi S., Karki R.G., Kang S.-U., Wang X., Worthy K.M., Bindu L.K., Nicklaus M.C., Fisher R.J., Burke T.R.Jr.
    Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing γ-methylphenylalanyl based phosphotyrosyl mimetics.
    J. Med. Chem. 48(3) 764-772 (2005) [Link]
  23. Shi Z.-D., Karki R.G., Oishi S., Worthy K.M., Bindu L.K., Dharmawardana P.G., Nicklaus M.C., Bottaro D.P., Fisher R.J., Burke T.R.Jr.
    Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.
    Bioorg. Med. Chem. Lett. 15(5) 1385-1388 (2005) [Link]
  24. Oishi S., Shi Z.-D., Worthy K.M., Bindu L.K., Fisher R.J., Burke T.R.Jr.
    Ring-closing metathesis of C-terminal allylglycine residues with an N- terminal b-vinyl-substituted phosphotyrosyl mimetic as an approach to novel Grb2 SH2 domain-binding macrocycles.
    Chem. Bio. Chem. 6(4) 668-674 (2005) [Link]
  25. Oishi S., Karkia R.G., Shia Z.-D., Worthyb K. M., Bindub L., Chertovb O., Espositoc D., Frankc P., Gillettec W. K., Maderiaa M., Hartleyc J., Nicklausa M. C., Barchi J. J. Jr., Fisherb R. J., Burke T. R. Jr.
    Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal β-vinyl-substituted phosphotyrosyl mimetic.
    Bioorg. Med. Chem. 13(7) 2431-2438 (2005) [Link]

2004

  1. Allen C.D., Ansel K.M., Low C., Lesley R., Tamamura H., Fujii N., Cyster J.G.
    Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.
    Nat. Immunol. 5 943-952 (2004) [Link]
  2. Yokoyama F., Suzuki N., Haruki M., Nishi N., Oishi S., Fujii N., Utani A., Kleinman H.K., Nomizu M.
    Cyclic peptides from the loop region of the laminin alpha4 chain LG4 module show enhanced biological activity over linear peptides.
    Biochemistry, 43(42) 13590-13597 (2004) [Link]
  3. Otaka A., Ueda S., Tomita K., Yano Y., Tamamura H., Matsuzaki K., Fujii N.
    Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation.
    Chem. Commun. 7(15) 1722-1723 (2004) [Link]
  4. Yamamoto N., Yang R., Yoshinaka Y., Amari S., Nakano T., Cinatl J., Rabenau H., Doerr H.W., Hunsmann G., Otaka A., Tamamura H., Fujii N., Yamamoto N.
    HIV protease inhibitor, nelfinavir, inhibits replication of SARS-associted coronavirus.
    Biochem. Biophys. Res. Commun. 318(3) 719-725 (2004) [Link]
  5. Tamamura H., Fujisawa M., Hiramatsu K., Mizumoto M., Nakashima H., Yamamoto N., Otaka A., Fujii N.
    Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent.
    FEBS Lett. 569(1-3) 99-104 (2004) [Link]
  6. Peng H., Huang Y., Rose J., Erichsen D., Herek S., Fujii N., Tamamura H., Zheng J.
    Stromal cell-derived factor 1 mediated CXCR4 signaling in rat and human cortical neural progenitor cells.
    Journal of Neuroscience Research, 76(1) 35-50 (2004) [Link]
  7. Takenaga M., Tamamura H., Hiramatsu K., Nakamura N., Yamaguchi N., Kitagawa A., Kawai S., Mizushima Y., Nakashima H., Fujii N., Igarashi R.
    A single treatment with microcapsules containing a CXCR4 antagonist suppressed pulmonary metastasis of murine melanoma.
    Biochem. Biophys. Res. Commun. 320(1) 226-232 (2004) [Link]
  8. Otaka A., Watanabe J., Yukimasa A., Sasak Y., Watanabe H., Kinoshita T., Oishi S., Tamamura H., Fujii N.
    SmI2-mediated reduction of γ,γ-difluoro-α,β-enoates and its application to the synthesis of (Z)-fluoroalkene-type dipeptide isosteres.
    J. Org. Chem. 69(5) 1634-1645 (2004) [Link]
  9. Mori T., Doi R., Masui T., Koizumi M., Toyoda E., Tulachan S.S., Ito D., Kami K., Masui T., Fujimoto K., Tamamura H., Hiramatsu K., Fujii N., Imamura M.
    CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer.
    Molecular Cancer Therapeutics, 3 29-37 (2004) [Link]
  10. Masui T., Dori R., Mori T., Tsuji S., Nakajima S., Koizumi M., Toyoda E., Tulachan S.S., Ito D., Kami K., Kuhara T., Fujii N., Oishi S., Niida A., Peiper S.C., Broach J.R., Imamura M.
    Metastin and its variant forms suppress migration of pancreatic cancer cells.
    Biochem. Biophys. Res. Commun. 315(1) 85-92 (2004) [Link]
  11. Ohno H., Takemoto Y., Fujii N., Tanaka T., Ibuka T.
    Stereodivergent synthesis of chiral 2-alkenylaziridines: paladium(0)-catalyzed 2,3-cis-selective aziridination and base-mediated 2,3-trans-selective aziridination.
    Chem. Pharm. Bull. 52(1) 111-119 (2004) [Link]
  12. Yanada R., Koh Y., Nashimori N., Matsumura A., Obika S., Mitsuya H., Fujii N., Takemoto Y.
    Indium-mediated atom-transfer and reductive radical cyclizations of iodoalkynes: synthesis and biological evaluation of HIV-protease inhibitors.
    J. Org. Chem. 69(7) 2417-2422 (2004) [Link]
  13. Tamamura H., Mizumoto M.. Hiramatsu K., Kusano S., Terakuba S., Yamamoto N., Trent J.O., Wang Z., Peiper S.C., Nakashima H., Otaka A., Fujii N.
    Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides.
    Org. Biomol. Chem. 2(8) 1255-1257 (2004) [Link]
  14. Ohno H., Iwasaki H., Eguchi T., Tanaka T.
    The first samarium(II)-mediated aryl radical cyclisation onto an aromatic ring.
    Chem. Commun. 19 2228-2229 (2004) [Link]
  15. Hayashi K., Rahman S.M.A., Ohno H., Tanaka T., Toyooka N., Nemoto H., Hayashi T.
    Evaluation of scopadulciol-related molecules for their stimulatory effect on the cytotoxicity of acyclovir and ganciclovir against herpes simplex virus type 1 thymidine kinase gene-transfected HeLa cells.
    Chem. Pharm. Bull. 52(8) 1015-1017 (2004) [Link]
  16. Ohno H., Hamaguchi H., Ohata M., Kosaka S., Tanaka T.
    Palladium(0)-catalyzed synthesis of medium-sized heterocycles by using bromoallenes as an allyl dication dquivalent.
    J. Am. Chem. Soc. 126(28) 8744-8754 (2004) [Link]
  17. Ohno H., Takeoka Y., Kadoh Y., Miyamura K., Tanaka T.
    Palladium(0)-catalyzed stereoselective cyclization of allenenes: divergent synthesis of pyrrolidines and 3-azabicyclo[3.1.0]hexanes from single allenene.
    J. Org. Chem. 69(13) 4541-4544 (2004) [Link]
  18. Ohno H., Hiramatsu K., Tanaka T.
    Asymmetric construction of quaternary carbon centers by allyltitanium-mediated stereospecific ring-opening reaction of 2,3-epoxy alcohols.
    Tetrahedron Lett. 45(1) 75-78 (2004) [Link]
  19. Oishi S., Kang S.-K., Liu H., Zhang M., Yang D., Deschampsc J.R., Burke T.R.Jr.
    Synthesis of a,a-disubstituted 4-phosphonophenylalanine analogues as conformationally-constrained phosphotyrosyl mimetics.
    Tetrahedron, 60(13) 2971-2977 (2004) [Link]

2003

  1. Tamamura H., Koh Y., Ueda S., Sasaki Y., Yamasaki T., Aoki M., Maeda K., Watai Y., Arikuni H., Otaka A., Mitsuya H., Fujii N.
    Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multi-drug resistant HIV-1 strains.
    J. Med. Chem. 46(9) 1764-1768 (2003) [Link]
  2. Ogawa M., Hatano K., Oishi S., Kawasumi Y., Fujii N., Kawaguchi M., Doi R., Imamura M., Yamamoto M., Ajito K., Mukai T., Saji H., Ito K.
    Direct electrophilic radiofluorination of a cyclic RGD peptide for in vivo αvβ3 integrin related tumor imaging.
    Nucl. Med. Biol. 30(1) 1-9 (2003) [Link]
  3. Yasuda T., Poole A.R., Shimizu M., Nakagawa T., Julovi S.M., Tamamura H., Fujii N., Nakamura T.
    Involvement of CD44 in induction of matrix metalloproteinases by a COOH-termenal heparin-binding fragment of fibronectin in human articular cartilage in culture.
    Arthritis & Rheumatism, 48(5) 1271-1280 (2003) [Link]
  4. Fujii N., Oishi S., Hiramatsu K., Araki T., Ueda S., Tamamura H., Otaka A., Kusano S., Terakubo S., Nakashima H., Broach J.A., Trent J.H., Wang X.Z., Peiper S.C.
    Molecular size reduction of a potent CXCR4-chemokimne antagonists using orthogonal combination of conformation-based and sequence-based libraries.
    Angew. Chem. Int. Ed. Engl. 42(28) 3251-3253 (2003) [Link]
  5. Tamamura H., Hori A., Kanzaki N., Hiramatsu K., Mizumoto M., Nakashima H., Yamamoto N., Otaka A., Fujii N.
    T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer.
    FEBS Lett. 550(1-3) 79-83 (2003) [Link]
  6. Otaka A., Yukimasa A., Watanabe J., Sasaki Y., Oishi S., Tamamura H., Fujii N.
    Application of samarium diiodide (SmI2)-induced reduction of γ-acetoxy-α,β-enoates with α-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives.
    Chem. Commun. 15 1834-1835 (2003) [Link]
  7. Tamamura H., Kato T., Otaka A., Fujii N.
    Synthesis of potent β-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies.
    Org. Biomol. Chem. 1(14) 2468-2473 (2003) [Link]
  8. Hanna J., Wald O., Goldman-Wohl D., Pruss D., Markel G., Gazit R., Katz G., Haimov-Kochman R., Fujii N., Yagel S., Peled A., Mandelboim O.
    CXCL12 expression by invasive trophoblasts induces the specific migration of CD16 negative human natural killer cells.
    Blood, 102(5) 1569-1577 (2003) [Link]
  9. Trent J.O., Wang Z.X., Murray J.L., Shao W., Tamamura H., Fujii N., Peiper S.C.
    Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists.
    J. Biol. Chem. 278(47) 47136-47144 (2003) [Link]
  10. Burger M., Glodek A., Hartmann T., Schmitt-Graft A., Seilberstein L.E., Fujii N., Kipps T.J., Burger J.A.
    Functional expression of CXCR4(CD184) on small cell lung cancer cells (SCLC) mediates migration, integrin activation, and adhesion to stronal cells.
    Oncogene, 22(50) 8093-8101 (2003) [Link]
  11. Tamamura H., Hiramatsu K., Kusano S., Terakubo S., Yamamoto N., Trent J.O., Wang Z.X., Peiper S.C., Nakashima H., Otaka A., Fujii N.
    Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives.
    Org. Biomol. Chem. 1(21) 3656-3662 (2003) [Link]
  12. Tamamura H., Hiramatsu K., Mizumoto M., Ueda S., Kusano S., Terakubo S., Akamatsu M., Yamamoto N., Trent J.O., Wang Z.X., Peiper S.C., Nakashima H., Otaka A., Fujii N.
    Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.
    Org. Biomol. Chem. 1(21) 3663-3669 (2003) [Link]
  13. Oonuma T., Morimatsu M., Nakagawa T., Uyama R., Sasaki N., Tamamura H., Fujii N., Hashimoto S., Yamamura H., Syuto B.
    Role of CXCR4 and SDF-1 in mammary tumor metastasis in the cat.
    J. Vet. Med. Sci. 65(10) 1069-1073 (2003) [Link]
  14. Suzuki N., Nakatsuka H., Mochizuki M., Nishi N., Kadoya Y., Utani A., Oishi S., Fujii N., Kleinman H.K., Nomizu M.
    Biological activities of homologous loop regions in the laminin alpha chain G domains.
    J. Biol. Chem. 278(46) 45697-45705 (2003) [Link]
  15. Ohno H., Takeoka Y., Miyamura K., Kadoh Y., Tanaka T.
    Novel synthesis of 3-azabicyclo[3.1.0]hexanes by unusual palladium(0)-catalyzed cyclopropanation of allenenes.
    Org. Lett. 5(25) 4763-4766 (2003) [Link]
  16. Ohno H., Hamaguchi H., Ohata M., Kosaka S., Tanaka T.
    Novel synthesis of azocine, azepine, oxocine, and oxepine derivatives by palladium-catalyzed medium-ring fomation from bromoallenes.
    Heterocycles, 61(1) 65-68 (2003) [Link]
  17. Ohno H., Okumura M., Maeda S., Iwasaki H., Wakayama R., Tanaka T.
    Samarium(II)-promoted radical spirocyclization onto an aromatic ring.
    J. Org. Chem. 68(20) 7722-7732 (2003) [Link]
  18. Ohno H., Wakayama R., Maeda S., Iwasaki H., Okumura M., Iwata C., Mikamiyama H., Tanaka T.
    Radical cyclization by ipso substitution of the methoxy group: considerable effect of HMPA on samarium-mediated cyclization.
    J. Org. Chem. 68(15) 5909-5919 (2003) [Link]
  19. Ohno H., Miyamura K., Takeoka Y., Tanaka T.
    Palladium(0)-catalyzed tandem cyclization of allenenes.
    Angew. Chem. Int. Ed. 42(23) 2647-2650 (2003) [Link]
  20. Ohno H., Hamaguchi H., Ohata M., Tanaka T.
    Bromoallenes as synthetic equivalents of allyl dications: synthesis of medium-sized nitrogen heterocycles through cyclization of bromoallenes in the presence of a palladium(0) catalyst and an alcohol.
    Angew. Chem. Int. Ed. 42(15) 1749-1753 (2003) [Link]
  21. Ogawa M., Hatano K., Oishi S., Kawasumi Y., Fujii N., Kawaguchi M., Doi R., Imamura M., Yamamoto M., Ajito K., Mukaie T., Saji H., Ito K.
    Direct electrophilic radiofluorination of a cyclic RGD peptide for in vivo avb3 integrin related tumor imaging.
    Nucl. Med. Biol. 30(1) 1-9 (2003) [Link]
  22. Tamamura H., Kato T., Otaka A., Fujii N.
    Synthesis of potent β-secretase inhibitors-containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies.
    Organic & Biomolecular Chemistry, 1(14) 2468-2473 (2003) [Link]
  23. Ara T., Itoi M., Kawabata K., Egawa T., Tokoyoda K., Sugiyama T., Fujii N., Amagai T., Nagasawa T.
    A Role of CXC Chemokine Ligand 12/Stromal Cell-Derived Factor-1/Pre-B Cell Growth Stimulating Factor and Its Receptor CXCR4 in Fetal and Adult T Cell Development in Vivo.
    Journal of Immunology, 170(9) 4649-4655 (2002) [Link]

2002

  1. Ohno H., Miyaura K., Tanaka T., Oishi S., Toda A., Takemoto Y., Fjii N., Ibuka T.
    Synthesis of allenes from allylic alcohol derivatives bearing a bromine atom using a palladium(0)/diethylzinc system.
    J. Org. Chem. 67(4) 1359-1367 (2002) [Link]
  2. Tamamura H., Hori T., Otaka A., Fujii N.
    Efficient stereoselective synthesis of peptidomimetics containing hydroxyethylamine dipeptide isosteres utilizing the aza-Payne rearrangement and O,N-acyl transfer reactions.
    J. Chem. Soc. Perkin Trans I, 577-580 (2002) [Link]
  3. Tamamura H., Hiramatsu K., Miyamaoto K., Omagari A., Oishi S., Nakashima H., Yamamoto N., Kuroda K., Nakagawa T., Otaka A., Fujii N.
    Synthesis and evaluation of pseudopeptide analogs of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the βII'-turn moiety.
    Bioorg. Med. Chem. Lett. 12(6) 923-928 (2002) [Link]
  4. Zhang W.-bo., Navenot J.-M., Bodduluri H., Tamamura H., Hiramatu K., Omagari A., Pei G., Manfredi J.P., Fujii N., Broach J., Peiper S.C.
    A point mutation that confers constitutive activity to CXCR4 reveals T140 is an inverse agonist and AMD3100 and ALX40-4C are weak partial agonists.
    J. Biol. Chem. 277(27) 24515-24521 (2002) [Link]
  5. Oishi S., Kamano T., Niida A., Odagaki Y., Tamamura H., Otaka A., Hamanaka N., Fujii N.
    Diastereoselective synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-SN2' reaction.
    Org. Lett. 4(7) 1051-1054 (2002) [Link]
  6. Oishi S., Niida A., Kamano T., Odagaki Y., Tamamura H., Otaka A., Hamanaka N., Fujii N.
    Diastereoselective synthesis of ψ[(E)-CMe=CH]- and ψ[(E)-CMe=CMe]-type dipeptide isosteres based on organocopper-mediated anti-SN2' reaction.
    Org. Lett. 4(7) 1055-1058 (2002) [Link]
  7. Anzai M., Yanada R., Fujii N., Ohno H., Ibuka T., Takemoto Y.
    Asymmetric synthesis ofβ2,3-amino acids by InI-Pd(0)-promoted metalation and addition of chiral 2-vinylaziridines.
    Tetrahedron, 58(26) 5231-5239 (2002) [Link]
  8. Yanada R., Nisihmori N., Matsumura A., Fujii N., Takemoto Y.
    Indium-mediated atom-transfer cyclization and reductive cyclization.
    Tetrahedron Lett. 43(26) 4585-4588 (2002) [Link]
  9. Otaka A., Nakamura M., Nameki D., Kodama E., Uchiyama S., Nakamura S., Nakano H., Tamamura H., Kobayashi Y., Matsuoka M., Fujii N.
    Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells.
    Angew. Chem. Int. Ed. Engl. 41(16) 2937-2940 (2002) [Link]
  10. Tamamura H., Omagari A., Hiramatsu K., Oishi S., Habashita H., Kanamoto T., Gotoh K., Yamamoto N., Nakashima H., Otaka A., Fujii N.
    Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study.
    Bioorg. Med. Chem. 10(5) 1417-1426 (2002) [Link]
  11. Hosotani R., Miyamoto Y., Fujimoto K., Doi R., Otaka A., Fujii N., Imamura M.
    Trojan p16 peptide suppresses pancreatic cancer growth and prolongs survival in mice.
    Clin. Cancer Res. 8(4) 1271-1276 (2002) [Link]
  12. Oishi S., Niida A., Kamano T., Miwa Y., Taga T., Odagaki Y., Hamanaka N., Yamamoto M., Akaji K., Tamamura H., Otaka A., Fujii N.
    Regio- and stereoselective ring-opening of chiral 1,3-oxazolidin-2-one derivatives by organocopper reagents provides novel access to di-, tri- and tetra-substituted alkene dipeptide isosteres.
    J. Chem. Soc. Perkin Trans I, 1786-1793(2002) [Link]
  13. Otaka A., Katagiri F., Kinoshita T., Odagaki Y., Oishi S., Tamamura H., Hamanaka N., Fujii N.
    Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-SN2' reactions.
    J. Org. Chem. 67(17) 6152-6161 (2002) [Link]
  14. Oishi S., Kamano T., Niida A., Odagaki Y., Hamanaka N., Yamamoto M., Ajito K., Tamamura H., Otaka A., Fujii N.
    Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics.
    J. Org. Chem. 67(17) 6162-6173 (2002) [Link]
  15. Lee J.U., Hosotani R., Wada M., Doi R., Koshiba T., Fujimoto K., Miyamoto Y., Tsuji S., Nakajima S., Hirohashi M., Uehara T., Arano Y., Fujii N., Imamura M.
    Antiproliferative activity induced by the somatostatin analogue, TT-232, in human pancreatic cancer cells.
    Eur. J. Cancer 38(11) 1526-1534 (2002) [Link]
  16. Owen S.M., Rudolph D., Schols D., Fujii N., Yamamoto N., Lal R.B.
    Susceptibility of diverse primary HIV isolates with varying co-receptor specificity's to CXCR4 antagonistic compounds.
    J. Med. Virol. 68(2) 147-155 (2002) [Link]
  17. Petit I., Szyper-Kravitz M., Nagler A., Lahav M., Peled A., Habler L., Ponomaryov T., Taichman R., Arenzana-Seisdedos F., Fujii N., Sandbank J., Zipori D., Lapidot T.
    G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.
    Nature Immunology, 3 687-694 (2002) [Link]
  18. Zhang W.-bo., Navenot J.-M., Bodduluri H., Tamamura H., Hiramatu K., Omagari A., Pei G., Manfredi J.P., Fujii N., Broach J., Peiper S.C.
    CXCR4 variants with autonomous signaling conferred by a single mutation in the third transmembrane domain reveal T140 is an inverse agonist and AMD3100 and ALX40-4C are weak partial agonists.
    J. Biol. Chem. 277(27) 24515-24521 (2002) [Link]
  19. Taniguchi Y., Karlstrom H., Lundkvist J., Mizutani T., Otaka A., Vestling M., Bernstein A., Donoviel D., Lendahl U., Honjo T.
    Notch receptor cleavage depends on but is not directly executed by presenilins.
    Proc. Natl. Acad. Sci. U S A. 99 4014-4019 (2002) [Link]
  20. Ohno H., Ando K., Hamaguchi H., Takeoka Y., Tanaka T.
    A highly cis-selective synthesis of 2-ethynylaziridines by intramolecular amination of chiral bromoallenes: improvement of stereoselectivity based on the computational investigation.
    J. Am. Chem. Soc. 124(51) 15255-15266 (2002) [Link]
  21. Ohno H., Maeda S., Okumura M., Wakayama R., Tanaka T.
    The first samarium(II)-mediated stereoselective spirocyclization onto an aromatic ring.
    Chem. Commun. 4() 316-317 (2002) [Link]