実践創薬研究プロジェクト 京都大学大学院薬学研究科

EN
menu

京都大学大学院薬学研究科　バイオ医薬品化学分野／
医薬基盤・健康・栄養研究所　先進バイオ医薬品プロジェクト

業績

このページでは、分野発の業績に加え、秋葉の業績を紹介しています。

大野浩章の業績はこちら（京大薬学研究科・創薬有機化学分野）

鎌田春彦の業績はこちら（医薬基盤研・バイオ創薬プロジェクト）

論文

2023年

2021年

  • Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support
    Ito T, Minamitani T, Hayakawa M, Otsubo R, Akiba H, Tsumoto K, Matsumoto M, Yasui T
    Sci. Rep. 11, 22341 (2021).
    https://doi.org/10.1038/s41598-021-01696-3
  • Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing
    Akiba H, Ise T, Nagata S, Kamada H, Ohno H, Tsumoto K
    Sci. Rep. 11, 19411 (2021).
    https://doi.org/10.1038/s41598-021-98855-3
  • Epitope-dependent thermodynamic signature of single-domain antibodies against hen egg lysozyme
    Akiba H, Tamura H, Caaveiro JMM, Tsumoto K
    J. Biochem. 170, 623-629 (2021).
    https://doi.org/10.1093/jb/mvab082
  • Novel neutralizing human monoclonal antibodies against tetanus neurotoxin
    Minamitani T, Kiyose K, Otsubo R, Ito T, Akiba H, Furuta RA, Inoue T, Tsumoto K, Satake M, Yasui T
    Sci. Rep. 11, 12134 (2021).
    https://doi.org/10.1038/s41598-021-91597-2

2020年

  • The Kg-antigen, RhAG with a Lys164Gln mutation, gives rise to haemolytic disease of the newborn
    Tanaka M, Abe T, Minamitani T, Akiba H, Horikawa T, Tobita R, Isa K, Ogasawara K, Takahashi H, Tateyama H, Tone S, Tsumoto K, Yasui T, Kimura T, Fujimura Y, Hirayama F, Tani Y, Takihara Y
    Br. J. Haematol. 191, 920-926 (2020).
    https://doi.org/10.1111/bjh.16955
  • Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain
    Xie J, Gonzalez-Carter D, Tockary TA, Nakamura N, Xue Y, Nakakido M, Akiba H, Dirisala A, Liu X, Toh K, Yang T, Wang Z, Fukushima S, Li J, Quader S, Tsumoto K, Yokota T, Anraku Y, Kataoka K
    ACS Nano, 14, 6729-6742 (2020).
    https://doi.org/10.1021/acsnano.9b09991
  • 64Cu-labeled minibody D2101 visualizes CDH17-positive gastric cancer xenografts with short waiting time
    Fujiwara K, Akiba H, Tsuji AB, Sudo H, Sugyo A, Nagatsu K, Zhang MR, Iwanari H, Kusano-Arai O, Kudo S, Kikuchi C, Tsumoto K, Momose T, Hamakubo T, Higashi T
    Nucl. Med. Commun. 41, 688-695 (2020).
    https://doi.org/10.1097/mnm.0000000000001203
  • GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab
    Kato D, Yaguchi T, Iwata T, Katoh Y, Morii K, Tsubota K, Takise Y, Tamiya M, Kamada H, Akiba H, Tsumoto K, Serada S, Naka T, Nishimura R, Nakagawa T, Kawakami Y
    eLife 9, e49392 (2020).
    https://doi.org/10.7554/eLife.49392
  • Computer-guided library generation applied to the optimization of single-domain antibodies
    Akiba H, Tamura H, Caaveiro JMM, Tsumoto K
    Prot. Eng. Des. Selec. 32, 423-431 (2020)
    https://doi.org/10.1038/s41598-019-50722-y
  • Generation of biparatopic antibody through two-step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher
    Akiba H, Takayanagi K, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K
    Biotechnol. Rep. 25, e00418 (2020)
    https://doi.org/10.1016/j.btre.2020.e00418

総説・著書・邦文誌等

  • バイパラトピック抗体の合理的設計に向けて
    秋葉宏樹
    蛋白質科学会アーカイブ, 16, eEssay 12 (2023)
    https://www.pssj.jp/archives/essay/Es_12/Es_12.html
  • Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins
    Akiba H, Tsumoto K
    Translat. Regulat. Sci. 2, 1-6 (2020) (Review)
    https://doi.org/10.33611/trs.2_1
  • 人工知能と分散協調型の実験自動化装置群を用いた、variantome型の抗体・ペプチド医薬品探索
    興野 悠太郎, 鈴木 祥平, 山﨑 昌子, 玉木 聡志, 伊原 頌二, 秋葉 宏樹, 小川 隆
    人工知能学会誌 35(1), 61-63 (2020)

2019年以前の秋葉宏樹の業績はこちら→

トップへ戻る