佐治　英郎

Hideo Saji, Ph.D.

佐治先生写真Department of Patho-Functional Bioanalysis
Professor

Kyoto University
Graduate School of Pharmaceutical Sciences
46-29 Yoshida Shimoadachi-cho, Sakyo-ku,
Kyoto 606-8501, Japan

Phone: +81-75-753-4556 
Fax +81-75-753-4568
E-mail saji-mail

Biography

Education:

Undergraduate Course

1970-1974: Faculty of Pharmaceutical Sciences, Kyoto University.
Major: Pharmaceutical Sciences. Degree B.S.

Graduate Course

1974-1976:  Graduate School of Pharmaceutical Sciences, Kyoto University
Major: Radiopharmaceutical Chemistry. Degree M.S.
1976-1980:  Graduate School of Pharmaceutical Sciences, Kyoto University
Major: Radiopharmaceutical Chemistry. Degree Ph.D. 

Professional Appointments:

1977-1980:  Instructor
School of Medicine, Kyoto University
Department of Nuclear Medicine. 
1980-1982:  Research Assistant
Washington University (St. Louis, U.S.A.) 
1982-1988:  Head of Cyclotron Facilities
School of Medicine, Kyoto University
Department of Nuclear Medicine. 
1988-1996:  Associate Professor
Faculty of Pharmaceutical Sciences, Kyoto University.
Department of Radiopharmaceutical Chemistry. 
1996-1997:  Professor
Faculty of Pharmaceutical Sciences, Kyoto University.
Department of Radiopharmaceutical Chemistry. 
1997- present:  Professor
Graduate School of Pharmaceutical Sciences, Kyoto University
Department of Patho-Functional Bioanalysis.

Publication List (2006-2011)

2011

  1. Shimizu, Y.; Temma, T.; Sano, K.; Ono, M.; Saji, H., Development of membrane type-1 matrix metalloproteinase-specific activatable fluorescent probe for malignant tumor detection. Cancer Sci 2011.
  2. Mukai, T.; Hagimori, M.; Arimitsu, K.; Katoh, T.; Ukon, M.; Kajimoto, T.; Kimura, H.; Magata, Y.; Miyoshi, E.; Taniguchi, N.; Node, M.; Saji, H., Synthesis and evaluation of a radioiodinated trisaccharide derivative as a synthetic substrate for a sensitive N-acetylglucosaminyltransferase V radioassay. Bioorg Med Chem 2011,19(14), 4312-21.
  3. Cui, M.; Ono, M.; Kimura, H.; Liu, B.; Saji, H., Novel quinoxaline derivatives for in vivo imaging of beta-amyloid plaques in the brain. Bioorg Med Chem Lett 2011, 21 (14), 4193-6.
  4. Cui, M.; Ono, M.; Kimura, H.; Liu, B.; Saji, H., Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for beta-amyloid plaques. Bioorg Med Chem 2011, 19 (13), 4148-53.
  5. Ono, M.; Saji, H., SPECT Imaging Agents for Detecting Cerebral beta-Amyloid Plaques. Int J Mol Imaging 2011, 2011, 543267.
  6. Masuda, R.; Oishi, S.; Ohno, H.; Kimura, H.; Saji, H.; Fujii, N., Concise site-specific synthesis of DTPA-peptide conjugates: application to imaging probes for the chemokine receptor CXCR4. Bioorg Med Chem 2011, 19 (10), 3216-20.
  7. Cui, M.; Ono, M.; Kimura, H.; Kawashima, H.; Liu, B. L.; Saji, H., Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of beta-amyloid plaques in Alzheimer’s disease. Nucl Med Biol 2011, 38 (3), 313-20.
  8. Ono, M.; Cheng, Y.; Kimura, H.; Cui, M.; Kagawa, S.; Nishii, R.; Saji, H., Novel 18F-labeled benzofuran derivatives with improved properties for positron emission tomography (PET) imaging of beta-amyloid plaques in Alzheimer’s brains. J Med Chem 2011, 54 (8), 2971-9.
  9. Cui, M.; Ono, M.; Kimura, H.; Liu, B.; Saji, H., Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for beta-amyloid plaques. J Med Chem 2011, 54 (7), 2225-40.
  10. Makino, A.; Harada, H.; Okada, T.; Kimura, H.; Amano, H.; Saji, H.; Hiraoka, M.; Kimura, S., Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent. Nanomedicine 2011.
  11. Hagimori, M.; Mizuyama, N.; Yamaguchi, Y.; Saji, H.; Tominaga, Y., A novel small molecule fluorescent sensor for Zn2+ based on pyridine-pyridone scaffold. Talanta 2011, 83 (5), 1730-5.
  12. Cui, M.; Ono, M.; Kimura, H.; Liu, B. L.; Saji, H., Synthesis and biological evaluation of indole-chalcone derivatives as beta-amyloid imaging probe. Bioorg Med Chem Lett 2011, 21 (3), 980-2.
  13. Shono, Y.; Yokota, C.; Kuge, Y.; Kido, S.; Harada, A.; Kokame, K.; Inoue, H.; Hotta, M.; Hirata, K.; Saji, H.; Tamaki, N.; Minematsu, K., Gene expression associated with an enriched environment after transient focal ischemia. Brain Res 2011, 1376, 60-5.
  14. Ono, M.; Watanabe, H.; Watanabe, R.; Haratake, M.; Nakayama, M.; Saji, H., Diphenylpropynone derivatives as probes for imaging beta-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem Lett 2011, 21 (1), 117-20.
  15. Shimizu, S.; Atsumi, R.; Nakazawa, T.; Izumi, T.; Sudo, K.; Okazaki, O.; Saji, H., Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model. Arch Toxicol 2011, 85 (4), 347-53.
  16. Ueda, M.; Iida, Y.; Yoneyama, T.; Kawai, T.; Ogawa, M.; Magata, Y.; Saji, H., In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: persistent agonist binding inhibits the expression of antiallodynic effects. Synapse 2011, 65 (1), 77-83.
  17. Ono M, Hayashi S, Matsumura K, Kimura H, Okamoto Y, Ihara M, Takahashi R, Mori H, Saji H. Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer’s brains. ACS Chem Neurosci 2011, 2, 269-275.
  18. Matsumura K, Ono M, Hayashi S, Kimura H, Okamoto Y, Ihara M, Takahashi R, Mori H, Saji H. Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer’s disease brains. Med Chem Comm 2011, 2, 596-600.

2010

  1. Sano, K.; Temma, T.; Azuma, T.; Nakai, R.; Narazaki, M.; Kuge, Y.; Saji, H., A Pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast Agents. Mol Imaging Biol 2010.
  2. Temma, T.; Ogawa, Y.; Kuge, Y.; Ishino, S.; Takai, N.; Nishigori, K.; Shiomi, M.; Ono, M.; Saji, H., Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model. J Nucl Med 2010, 51 (12), 1979-86.
  3. Kudo, T.; Ueda, M.; Konishi, H.; Kawashima, H.; Kuge, Y.; Mukai, T.; Miyano, A.; Tanaka, S.; Kizaka-Kondoh, S.; Hiraoka, M.; Saji, H., PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel 18F-Labeled Biotin Derivative. Mol Imaging Biol 2010.
  4. Sano, K.; Temma, T.; Kuge, Y.; Kudo, T.; Kamihashi, J.; Zhao, S.; Saji, H., Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method. Biol Pharm Bull 2010, 33 (9), 1589-95.
  5. Cheng, Y.; Ono, M.; Kimura, H.; Kagawa, S.; Nishii, R.; Saji, H., A novel 18F-labeled pyridyl benzofuran derivative for imaging of beta-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem Lett 2010, 20 (20), 6141-4.
  6. Ono, M.; Ikeoka, R.; Watanabe, H.; Kimura, H.; Fuchigami, T.; Haratake, M.; Saji, H.; Nakayama, M., 99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral beta-amyloid plaques. Bioorg Med Chem Lett 2010, 20 (19), 5743-8.
  7. Ono, M.; Ishikawa, M.; Kimura, H.; Hayashi, S.; Matsumura, K.; Watanabe, H.; Shimizu, Y.; Cheng, Y.; Cui, M.; Kawashima, H.; Saji, H., Development of dual functional SPECT/fluorescent probes for imaging cerebral beta-amyloid plaques. Bioorg Med Chem Lett 2010, 20 (13), 3885-8.
  8. Kuge, Y.; Takai, N.; Ogawa, Y.; Temma, T.; Zhao, Y.; Nishigori, K.; Ishino, S.; Kamihashi, J.; Kiyono, Y.; Shiomi, M.; Saji, H., Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques. Eur J Nucl Med Mol Imaging 2010, 37 (11), 2093-104.
  9. Watanabe, H.; Ono, M.; Haratake, M.; Kobashi, N.; Saji, H.; Nakayama, M., Synthesis and characterization of novel phenylindoles as potential probes for imaging of beta-amyloid plaques in the brain. Bioorg Med Chem 2010, 18 (13), 4740-6.
  10. Ueda, M.; Kudo, T.; Kuge, Y.; Mukai, T.; Tanaka, S.; Konishi, H.; Miyano, A.; Ono, M.; Kizaka-Kondoh, S.; Hiraoka, M.; Saji, H., Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha. Eur J Nucl Med Mol Imaging 2010, 37 (8), 1566-74.
  11. Ueda, M.; Iida, Y.; Tominaga, A.; Yoneyama, T.; Ogawa, M.; Magata, Y.; Nishimura, H.; Kuge, Y.; Saji, H., Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects. Br J Pharmacol 2010, 159 (6), 1201-10.
  12. Zhao, T.; Harada, H.; Teramura, Y.; Tanaka, S.; Itasaka, S.; Morinibu, A.; Shinomiya, K.; Zhu, Y.; Hanaoka, H.; Iwata, H.; Saji, H.; Hiraoka, M., A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells. J Control Release 2010, 144 (1), 109-14.
  13. Aita, K.; Temma, T.; Shimizu, Y.; Kuge, Y.; Seki, K.; Saji, H., Synthesis of a new NIR fluorescent Nd complex labeling agent. J Fluoresc 2010, 20 (1), 225-34.
  14. Temma, T.; Iida, H.; Hayashi, T.; Teramoto, N.; Ohta, Y.; Kudomi, N.; Watabe, H.; Saji, H.; Magata, Y., Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable 15O-O2. Eur J Nucl Med Mol Imaging 2010, 37 (2), 377-85.
  15. Aita, K.; Temma, T.; Kuge, Y.; Seki, K.; Saji, H., NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging. Luminescence 2010, 25 (1), 19-24.
  16. Ono M, Ikeoka R, Watanabe H, Kimura H, Fuchigami T, Haratake M, Saji H, Nakayama M. Synthesis and evaluation of novel chalcone derivatives with 99mTc/Re complexes as potential probes for detection of beta-amyloid plaques. ACS Chem Neurosci 2010, 1, 598-607.
  17. Cheng Y, Ono M, Kimura H, Kagawa S, Nishii R, Kawashima H, Saji H. Fluorinated benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer’s disease brains. ACS Med Chem Lett 2010, 1, 321-325.
  18. Ono M, Fuchi Y, Fuchigami T, Kobashi N, Kimura H, Haratake M, Saji H, Nakayama M. Novel benzofurans with 99mTc complexes as probes for imaging cerebral beta-amyloid plaques using single photon emission computed tomography. ACS Med Chem Lett 2010, 1, 443-447.

2009

  1. Ogawa, K.; Kawashima, H.; Kinuya, S.; Shiba, K.; Onoguchi, M.; Kimura, H.; Hashimoto, K.; Odani, A.; Saji, H., Preparation and evaluation of 186/188Re-labeled antibody (A7) for radioimmunotherapy with rhenium(I) tricarbonyl core as a chelate site. Ann Nucl Med 2009, 23 (10), 843-8.
  2. Kuge, Y.; Obokata, N.; Kimura, H.; Katada, Y.; Temma, T.; Sugimoto, Y.; Aita, K.; Seki, K.; Tamaki, N.; Saji, H., Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression. Nucl Med Biol 2009, 36 (8), 869-76.
  3. Ono, M.; Watanabe, R.; Kawashima, H.; Cheng, Y.; Kimura, H.; Watanabe, H.; Haratake, M.; Saji, H.; Nakayama, M., Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of beta-amyloid plaques in Alzheimer’s disease. J Med Chem 2009, 52 (20), 6394-401.
  4. Ono, M.; Hayashi, S.; Kimura, H.; Kawashima, H.; Nakayama, M.; Saji, H., Push-pull benzothiazole derivatives as probes for detecting beta-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem 2009, 17 (19), 7002-7.
  5. Mukai, E.; Toyoda, K.; Kimura, H.; Kawashima, H.; Fujimoto, H.; Ueda, M.; Temma, T.; Hirao, K.; Nagakawa, K.; Saji, H.; Inagaki, N., GLP-1 receptor antagonist as a potential probe for pancreatic beta-cell imaging. Biochem Biophys Res Commun 2009, 389 (3), 523-6.
  6. Watanabe, H.; Ono, M.; Ikeoka, R.; Haratake, M.; Saji, H.; Nakayama, M., Synthesis and biological evaluation of radioiodinated 2,5-diphenyl-1,3,4-oxadiazoles for detecting beta-amyloid plaques in the brain. Bioorg Med Chem 2009, 17 (17), 6402-6.
  7. Temma, T.; Sano, K.; Kuge, Y.; Kamihashi, J.; Takai, N.; Ogawa, Y.; Saji, H., Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors. Biol Pharm Bull 2009, 32 (7), 1272-7.
  8. Kudo, T.; Ueda, M.; Kuge, Y.; Mukai, T.; Tanaka, S.; Masutani, M.; Kiyono, Y.; Kizaka-Kondoh, S.; Hiraoka, M.; Saji, H., Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells. J Nucl Med 2009, 50 (6), 942-9.
  9. Saji, H.; Kikuchi, K., [Molecular imaging for acceleration of drug discovery & development and innovation of clinical diagnosis and therapy]. Yakugaku Zasshi 2009, 129 (3), 263-4.
  10. Ogawa, M.; Tsukada, H.; Hatano, K.; Ouchi, Y.; Saji, H.; Magata, Y., Central in vivo nicotinic acetylcholine receptor imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT). Biol Pharm Bull 2009, 32 (3), 337-40.
  11. Ogawa, K.; Kawashima, H.; Shiba, K.; Washiyama, K.; Yoshimoto, M.; Kiyono, Y.; Ueda, M.; Mori, H.; Saji, H., Development of [90Y]DOTA-conjugated bisphosphonate for treatment of painful bone metastases. Nucl Med Biol 2009, 36 (2), 129-35.
  12. Ono, M.; Watanabe, R.; Kawashima, H.; Kawai, T.; Watanabe, H.; Haratake, M.; Saji, H.; Nakayama, M., 18F-labeled flavones for in vivo imaging of beta-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem 2009, 17 (5), 2069-76.
  13. Maya, Y.; Ono, M.; Watanabe, H.; Haratake, M.; Saji, H.; Nakayama, M., Novel radioiodinated aurones as probes for SPECT imaging of beta-amyloid plaques in the brain. Bioconjug Chem 2009, 20 (1), 95-101.
  14. Ogawa, K.; Mukai, T.; Kawai, K.; Takamura, N.; Hanaoka, H.; Hashimoto, K.; Shiba, K.; Mori, H.; Saji, H., Usefulness of competitive inhibitors of protein binding for improving the pharmacokinetics of 186Re-MAG3-conjugated bisphosphonate (186Re-MAG3-HBP), an agent for treatment of painful bone metastases. Eur J Nucl Med Mol Imaging 2009, 36 (1), 115-21.

2008

  1. Ishino, S.; Mukai, T.; Kuge, Y.; Kume, N.; Ogawa, M.; Takai, N.; Kamihashi, J.; Shiomi, M.; Minami, M.; Kita, T.; Saji, H., Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque. J Nucl Med 2008, 49 (10), 1677-85.
  2. Doue, T.; Ohtsuki, K.; Ogawa, K.; Ueda, M.; Azuma, A.; Saji, H.; Strauss, H. W.; Matsubara, H., Cardioprotective effects of erythropoietin in rats subjected to ischemia-reperfusion injury: assessment of infarct size with 99mTc-annexin V. J Nucl Med 2008, 49 (10), 1694-700.
  3. Kuge, Y.; Kume, N.; Ishino, S.; Takai, N.; Ogawa, Y.; Mukai, T.; Minami, M.; Shiomi, M.; Saji, H., Prominent lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits. Biol Pharm Bull 2008, 31 (8), 1475-82.
  4. Ono, M.; Haratake, M.; Saji, H.; Nakayama, M., Development of novel beta-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole. Bioorg Med Chem 2008, 16 (14), 6867-72.
  5. Temma, T.; Kuge, Y.; Sano, K.; Kamihashi, J.; Obokata, N.; Kawashima, H.; Magata, Y.; Saji, H., PET O-15 cerebral blood flow and metabolism after acute stroke in spontaneously hypertensive rats. Brain Res 2008, 1212, 18-24.
  6. Kiyono, Y.; Sugita, T.; Ueda, M.; Kawashima, H.; Kanegawa, N.; Kuge, Y.; Fujibayashi, Y.; Saji, H., Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart. Nucl Med Biol 2008, 35 (2), 213-8.
  7. Saji, H., [Application of radiometallic compounds for medical diagnosis and therapy]. Yakugaku Zasshi 2008, 128 (3), 323-32.
  8. Ueda, M.; Iida, Y.; Kitamura, Y.; Kawashima, H.; Ogawa, M.; Magata, Y.; Saji, H., 5-Iodo-A-85380, a specific ligand for alpha 4 beta 2 nicotinic acetylcholine receptors, prevents glutamate neurotoxicity in rat cortical cultured neurons. Brain Res 2008, 1199, 46-52.
  9. Kotsuma, M.; Tokui, T.; Ishizuka-Ozeki, T.; Honda, T.; Iwabuchi, H.; Murai, T.; Ikeda, T.; Saji, H., CYP2D6-Mediated metabolism of a novel acyl coenzyme A:cholesterol acyltransferase inhibitor, pactimibe, and its unique plasma metabolite, R-125528. Drug Metab Dispos 2008, 36 (3), 529-34.
  10. Takatsuka, S.; Morita, T.; Horikiri, Y.; Yamahara, H.; Saji, H., Influence of various combinations of mucolytic agent and non-ionic surfactant on intestinal absorption of poorly absorbed hydrophilic compounds. Int J Pharm 2008, 349 (1-2), 94-100.

2007

  1. Akizawa, H.; Saito, M.; Tsukamoto, I.; Ohkura, T.; Shimizu, T.; Kitamura, Y.; Mifune, M.; Saito, Y.; Arano, Y.; Saji, H., Effect of carboxyl-group of D-glutamic acid or gamma-carboxy-D-glutamic acid as N-terminal amino acid of 111In-diethylenetriaminepentaacetic acid-octreotide on accumulation of radioactivity in kidney. Biol Pharm Bull 2007, 30 (11), 2226-8.
  2. Mamede, M.; Ishizu, K.; Ueda, M.; Mukai, T.; Iida, Y.; Kawashima, H.; Fukuyama, H.; Togashi, K.; Saji, H., Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study. J Nucl Med 2007, 48 (11), 1829-35.
  3. Kuge, Y.; Takai, N.; Ishino, S.; Temma, T.; Shiomi, M.; Saji, H., Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atherosclerosis: comparison with plaque instability analysis. Biol Pharm Bull 2007, 30 (9), 1634-40.
  4. Kiyono, Y.; Kuge, Y.; Katada, Y.; Kawashima, H.; Magata, Y.; Saji, H., Applicability of a high-resolution small semiconductor gamma camera to small animal imaging. Nucl Med Commun 2007, 28 (9), 736-41.
  5. Aita, K.; Temma, T.; Kuge, Y.; Saji, H., Development of a novel neodymium compound for in vivo fluorescence imaging. Luminescence 2007, 22 (5), 455-61.
  6. Hanaoka, H.; Mukai, T.; Habashita, S.; Asano, D.; Ogawa, K.; Kuroda, Y.; Akizawa, H.; Iida, Y.; Endo, K.; Saga, T.; Saji, H., Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors. Nucl Med Biol 2007, 34 (5), 503-10.
  7. Oishi, N.; Hashikawa, K.; Yoshida, H.; Ishizu, K.; Ueda, M.; Kawashima, H.; Saji, H.; Fukuyama, H., Quantification of nicotinic acetylcholine receptors in Parkinson’s disease with 123I-5IA SPECT. J Neurol Sci 2007, 256 (1-2), 52-60.
  8. Takatsuka, S.; Morita, T.; Horikiri, Y.; Yamahara, H.; Saji, H., Absorption enhancement of poorly absorbed hydrophilic compounds from various mucosal sites by combination of mucolytic agent and non-ionic surfactant. Int J Pharm 2007, 338 (1-2), 87-93.
  9. Saji, H., [Molecular imaging in evaluation of in vivo behavior of drugs]. Nippon Rinsho 2007, 65 (2), 363-9.
  10. Ishino, S.; Mukai, T.; Kume, N.; Asano, D.; Ogawa, M.; Kuge, Y.; Minami, M.; Kita, T.; Shiomi, M.; Saji, H., Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability–analysis in hypercholesterolemic rabbits. Atherosclerosis 2007, 195 (1), 48-56.
  11. Ishino, S.; Kuge, Y.; Takai, N.; Tamaki, N.; Strauss, H. W.; Blankenberg, F. G.; Shiomi, M.; Saji, H., 99mTc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits. Eur J Nucl Med Mol Imaging 2007, 34 (6), 889-99.
  12. Ogawa, K.; Mukai, T.; Asano, D.; Kawashima, H.; Kinuya, S.; Shiba, K.; Hashimoto, K.; Mori, H.; Saji, H., Therapeutic effects of a 186Re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model. J Nucl Med 2007, 48 (1), 122-7.
  13. Kiyono, Y.; Yamashita, T.; Doi, H.; Kuge, Y.; Katsura, T.; Inui, K.; Saji, H., Is MIBG a substrate of P-glycoprotein? Eur J Nucl Med Mol Imaging 2007, 34 (4), 448-52.

2006

  1. Ogawa, K.; Mukai, T.; Inoue, Y.; Ono, M.; Saji, H., Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent. J Nucl Med 2006, 47 (12), 2042-7.
  2. Ogawa, M.; Magata, Y.; Kato, T.; Hatano, K.; Ishino, S.; Mukai, T.; Shiomi, M.; Ito, K.; Saji, H., Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques. J Nucl Med 2006, 47 (11), 1845-50.
  3. Ogawa, K.; Mukai, T.; Arano, Y.; Otaka, A.; Ueda, M.; Uehara, T.; Magata, Y.; Hashimoto, K.; Saji, H., Rhemium-186-monoaminemonoamidedithiol-conjugated bisphosphonate derivatives for bone pain palliation. Nucl Med Biol 2006, 33 (4), 513-20.
  4. Hanaoka, H.; Mukai, T.; Tamamura, H.; Mori, T.; Ishino, S.; Ogawa, K.; Iida, Y.; Doi, R.; Fujii, N.; Saji, H., Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors. Nucl Med Biol 2006, 33 (4), 489-94.
  5. Kitamura, Y.; Iida, Y.; Abe, J.; Mifune, M.; Kasuya, F.; Ohta, M.; Igarashi, K.; Saito, Y.; Saji, H., Release of vesicular Zn2+ in a rat transient middle cerebral artery occlusion model. Brain Res Bull 2006, 69 (6), 622-5.
  6. Shikano, N.; Nakajima, S.; Kotani, T.; Itoh, Y.; Nishii, R.; Yoshimoto, M.; Flores, L. G., 2nd; Saji, H.; Ishikawa, N.; Kawai, K., Detection of maleate-induced Fanconi syndrome by decreasing accumulation of 125I-3-iodo-alpha-methyl-L-tyrosine in the proximal tubule segment-1 region of renal cortex in mice: a trial of separate evaluation of reabsorption. Ann Nucl Med 2006, 20 (3), 175-81.
  7. Hosokawa, R.; Kambara, N.; Ohba, M.; Mukai, T.; Ogawa, M.; Motomura, H.; Kume, N.; Saji, H.; Kita, T.; Nohara, R., A catheter-based intravascular radiation detector of vulnerable plaques. J Nucl Med 2006, 47 (5), 863-7.
  8. Ono, M.; Kawashima, H.; Nonaka, A.; Kawai, T.; Haratake, M.; Mori, H.; Kung, M. P.; Kung, H. F.; Saji, H.; Nakayama, M., Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer’s disease brains. J Med Chem 2006, 49 (9), 2725-30.
  9. Kitamura, Y.; Iida, Y.; Abe, J.; Mifune, M.; Kasuya, F.; Ohta, M.; Igarashi, K.; Saito, Y.; Saji, H., In vivo measurement of presynaptic Zn2+ release during forebrain ischemia in rats. Biol Pharm Bull 2006, 29 (4), 821-3.
  10. Temma, T.; Magata, Y.; Kuge, Y.; Shimonaka, S.; Sano, K.; Katada, Y.; Kawashima, H.; Mukai, T.; Watabe, H.; Iida, H.; Saji, H., Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable15O-O2. J Cereb Blood Flow Metab 2006, 26 (12), 1577-83.
  11. Ogawa, M.; Iida, Y.; Nakagawa, M.; Kuge, Y.; Kawashima, H.; Tominaga, A.; Ueda, M.; Magata, Y.; Saji, H., Change of central cholinergic receptors following lesions of nucleus basalis magnocellularis in rats: search for an imaging index suitable for the early detection of Alzheimer’s disease. Nucl Med Biol 2006, 33 (2), 249-54.
  12. Kanegawa, N.; Kiyono, Y.; Kimura, H.; Sugita, T.; Kajiyama, S.; Kawashima, H.; Ueda, M.; Kuge, Y.; Saji, H., Synthesis and evaluation of radioiodinated (S,S)-2-(alpha-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter. Eur J Nucl Med Mol Imaging 2006, 33 (6), 639-47.
  13. Kitamura, Y.; Iida, Y.; Abe, J.; Ueda, M.; Mifune, M.; Kasuya, F.; Ohta, M.; Igarashi, K.; Saito, Y.; Saji, H., Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model. J Pharmacol Sci 2006, 100 (2), 142-8.
  14. Fukumitsu, N.; Suzuki, M.; Fukuda, T.; Kiyono, Y.; Kajiyama, S.; Saji, H., Reduced 125I-meta-iodobenzylguanidine uptake and norepinephrine transporter density in the hearts of mice with MPTP-induced parkinsonism. Nucl Med Biol 2006, 33 (1), 37-42.
  15. Kuge, Y.; Katada, Y.; Shimonaka, S.; Temma, T.; Kimura, H.; Kiyono, Y.; Yokota, C.; Minematsu, K.; Seki, K.; Tamaki, N.; Ohkura, K.; Saji, H., Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression. Nucl Med Biol 2006, 33 (1), 21-7.

ページの先頭に戻る