Division of Bioinformatics and Chemical Genomics

Departments Leaders Research Fields Research Profile
Pharmacogenomics / Genomic Drug Discovery
Associate Professor
  1. Discovery of novel drug target and its validation by integrative genome science
  2. In Silico drug discover and design by bioinformatics
  3. Ligand fishing of “orphan G-protein-coupled receptors” and structure-function analysis
  4. Functional genomic study using transgenic/knockout animals
Chemogenomics / Bioorganic Medicinal Chemistry
Hiroaki OHNO
  1. Synthesis of structurally complex bioactive compounds
  2. Novel methods for the synthesis of complex structures and their applications
  3. Identification of functional molecules based on designs, synthetic studies and chemical modifications of biomolecules
  4. Development of a novel screening platform using synthetic peptides and proteins
  5. Drug screening programs using in-house chemical libraries
Systems Biology
Masao DOI
  1. Molecular mechanisms of circadian time systems in mammals
  2. Circadian brain G-protein coupled receptor signaling for sleep and metabolism
  3. Molecular mechanisms of ageing-associated circadian rhythm disorders
  4. Translational research on circadian time-associated lifestyle diseases
  5. Development of new drugs for tuning circadian time systems
System Chemotherapy and Molecular Sciences
Hideaki KAKEYA
  1. Advanced chemical biology research for establishing system chemotherapy in order to cure
    multi-factorial diseases; e.g. cancer, infectious diseases, heart failure, immunodeficiency,
    diabetes, and neuronal diseases
  2. HCS (high-contents screening) and HTS (high throughput screening) for identifying useful
    small molecules (bioprobes)
  3. Natural product chemistry and medicinal chemistry for mining novel bioactive small molecules
  4. Biosynthetic studies of natural products and their application to combinatorial biosynthesis
Integrative Genomics

Hiroyuki OGATA

  1. Genomics of viruses
  2. Interactions between microbial communities and their environments
  3. Integration of chemical, genomics, and biomedical knowledge for drug discovery and environmental preservation
Chemical Biology

Motonari UESUGI

  1. In-depth analysis of human cells through organic-chemistry approaches
  2. Exogenous control of human cells with synthetic compounds
  3. Development of novel methods for discovering and using bioactive compounds
  4. Discovery and design of self-assembling bioactive molecules and intracellular self-assemblies
  5. Understanding of intracellular chemical signalings mediated by radical reactions