Division of Bioinformatics and Chemical Genomics

1. Discovery of novel drug target and its validation by integrative genome science
2. In Silico drug discover and design by bioinformatics
3. Ligand fishing of “orphan G-protein-coupled receptors” and structure-function analysis
4. Functional genomic study using transgenic/knockout animals

1. Synthesis of structurally complex bioactive compounds
2. Novel methods for the synthesis of complex structures and their applications
3. Identification of functional molecules based on designs, synthetic studies and chemical modifications of biomolecules
4. Development of a novel screening platform using synthetic peptides and proteins
5. Drug screening programs using in-house chemical libraries

1. Molecular mechanisms of circadian time systems in mammals
2. Circadian brain G-protein coupled receptor signaling for sleep and metabolism
3. Molecular mechanisms of ageing-associated circadian rhythm disorders
4. Translational research on circadian time-associated lifestyle diseases
5. Development of new drugs for tuning circadian time systems

1. Advanced chemical biology research for establishing system chemotherapy in order to cure
   multi-factorial diseases; e.g. cancer, infectious diseases, heart failure, immunodeficiency,
   diabetes, and neuronal diseases
2. HCS (high-contents screening) and HTS (high throughput screening) for identifying useful
   small molecules (bioprobes)
3. Natural product chemistry and medicinal chemistry for mining novel bioactive small　molecules
4. Biosynthetic studies of natural products and their application to combinatorial biosynthesis

Professor
Hiroyuki OGATA

1. Genomics of viruses
2. Interactions between microbial communities and their environments
3. Integration of chemical, genomics, and biomedical knowledge for drug discovery and environmental preservation

Professor
Motonari UESUGI

1. In-depth analysis of human cells through organic-chemistry approaches
2. Exogenous control of human cells with synthetic compounds
3. Development of novel methods for discovering and using bioactive compounds
4. Discovery and design of self-assembling bioactive molecules and intracellular self-assemblies
5. Understanding of intracellular chemical signalings mediated by radical reactions