Division of Pharmaceutical Sciences

1. Synthesis of Biologically Active Molecules
2. Development of New Synthetic Methodology for Complex Molecules
3. Molecular Architecture of Unique Organic Materials
4. Chemistry of Strained Molecules
5. Control of Molecular Dynamism

1. Design of environmentally friendly organocatalysts for process chemistry
2. Development of new reagents and synthetic methods using unique elements.
3. Total synthesis of biologically important synthetic and natural products
4. Molecular modification using multi-functional heterocycles
5. Innovative catalysts for large- and medium-sized glycopeptides

1. Molecular cloning of enzymes responsible for biosynthesis of secondary metabolites
2. Pharmacological studies on therapeutic use of incense and balm.
3. Phytochemical analyses of bio-active substances found in medicinal plants
4. Field surveys on medicinal plants for their diversity and sustainable use

1. Elucidation of the action mechanisms of antimicrobial peptides
2. Initiation mechanism of Alzheimer’s disease
3. Elucidation of membrane protein folding
4. Regulation of function of G-protein coupled receptors
5. Protein structure determination by NMR

1. Structural-basis for pharmacologic behaviour of ATP binding Cassette transporters
2. Development of a new technique of X-ray crystallography by X-ray free electron laser

1. Development of novel analytical technologies for proteomics
2. Functional analysis of human proteomes by high resolution LC/MS/MS
3. Elucidation of intracellular phosphorylation network analysis
4. Intelligent proteome analysis by biomolecular mass spectrometry integrated with statistical signal processing
5. Metaproteome analysis of microbiomes in human diseases.

1. Ca²⁺ signaling from intracellular stores
2. Novel signaling in central nervous system
3. Structure and function of muscle membrane systems

1. Analysis of mechanism of virus infection
2. Analysis of host factors in retroviral replication
3. Analysis of HIV-induced immunodeficiency
4. Development of novel anti-viral therapy

Professor
Koichi IKUTA

1. IL-7 receptor signals for differentiation and maturation of immune cells
2. Control of IL-7 receptor expression during differentiation and response of immune cells
3. Circadian control of dynamics and functions of immune cells by glucocorticoids
4. Visualization and local functions of cytokine-producing cells

Professor
Takahiro ITO

1. Regulatory mechanisms of cell fates in stem cells and cancer
2. Metabolic regulation of cancer cell fates in leukemia
3. Cell fate regulation by RNA binding proteins in myogenesis and muscle functions
4. Drug discovery and modulation of cell fates as therapeutic strategies in human malignancies

Genetics

Professor
Tatsushi IGAKI

1. Mechanism of cell competition
2. Genetic basis of tissue growth regulation
3. Molecular basis of tumor progression and metastasis

1. Molecular mechanisms of ciliogenesis and protein trafficking in cilia
2. Mechanism of transbilayer lipid asymmetry in biological membranes and cellular functions
3. Regulation mechanism of intracellular protein transport

Ikuo KIMURA

1. Signal transduction pathways involved in cancer progression.
2. Regulation of amino acid metabolism in cancer cells.

1. Creation of bioactive proteins that control cell function and genes
2. Development of peptide-based intracellular delivery systems for biomacromolecules
3. Design of peptides and proteins that induce membrane curvature
4. Design of artificial transcription factors that regulate gene expression
5. Assembly control of membrane proteins and the regulation of biological signals